N Marklund

Summary

Affiliation: Uppsala University Hospital
Country: Sweden

Publications

  1. doi request reprint Increased cerebral uptake of [18F]fluoro-deoxyglucose but not [1-14C]glucose early following traumatic brain injury in rats
    Niklas Marklund
    Department of Neuroscience, Uppsala University CSO, Imanet, Uppsala, Sweden
    J Neurotrauma 26:1281-93. 2009
  2. doi request reprint Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury
    Niklas Marklund
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Gothenburg, Sweden
    J Neurosurg 110:1227-37. 2009
  3. pmc Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice
    N Marklund
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroscience 163:540-51. 2009
  4. pmc Cognitive outcome following brain injury and treatment with an inhibitor of Nogo-A in association with an attenuated downregulation of hippocampal growth-associated protein-43 expression
    Niklas Marklund
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, USA
    J Neurosurg 107:844-53. 2007
  5. ncbi request reprint Effect of traumatic brain injury and nitrone radical scavengers on relative changes in regional cerebral blood flow and glucose uptake in rats
    Niklas Marklund
    Department of Neuroscience Neurosurgery, Uppsala University, Sweden
    J Neurotrauma 19:1139-53. 2002
  6. ncbi request reprint Monitoring of reactive oxygen species production after traumatic brain injury in rats with microdialysis and the 4-hydroxybenzoic acid trapping method
    N Marklund
    Department of Neuroscience and Neurosurgery, Clinical Chemistry at Uppsala University Hospital, Sweden
    J Neurotrauma 18:1217-27. 2001
  7. ncbi request reprint Free radical scavenger posttreatment improves functional and morphological outcome after fluid percussion injury in the rat
    N Marklund
    Department of Neuroscience and Neurosurgery, University Hospital, Uppsala, Sweden
    J Neurotrauma 18:821-32. 2001
  8. ncbi request reprint Neurointensive care management of raised intracranial pressure caused by severe valproic acid intoxication
    Niklas Marklund
    Department of Neuroscience, Uppsala University Hospital, Uppsala, 75185 Sweden
    Neurocrit Care 7:160-4. 2007
  9. pmc Selective temporal and regional alterations of Nogo-A and small proline-rich repeat protein 1A (SPRR1A) but not Nogo-66 receptor (NgR) occur following traumatic brain injury in the rat
    Niklas Marklund
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Neurol 197:70-83. 2006
  10. ncbi request reprint Energy metabolic changes in the early post-injury period following traumatic brain injury in rats
    Niklas Marklund
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, SE 75185 Uppsala, Sweden
    Neurochem Res 31:1085-93. 2006

Detail Information

Publications38

  1. doi request reprint Increased cerebral uptake of [18F]fluoro-deoxyglucose but not [1-14C]glucose early following traumatic brain injury in rats
    Niklas Marklund
    Department of Neuroscience, Uppsala University CSO, Imanet, Uppsala, Sweden
    J Neurotrauma 26:1281-93. 2009
    ..These results should be considered when interpreting results obtained using FDG for the estimation of lCMR(Glc) early following experimental TBI...
  2. doi request reprint Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury
    Niklas Marklund
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Gothenburg, Sweden
    J Neurosurg 110:1227-37. 2009
    ....
  3. pmc Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice
    N Marklund
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroscience 163:540-51. 2009
    ....
  4. pmc Cognitive outcome following brain injury and treatment with an inhibitor of Nogo-A in association with an attenuated downregulation of hippocampal growth-associated protein-43 expression
    Niklas Marklund
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, USA
    J Neurosurg 107:844-53. 2007
    ..To elucidate a potential molecular response to Nogo-A inhibition, we evaluated the effects of 7B12 on hippocampal GAP-43 expression...
  5. ncbi request reprint Effect of traumatic brain injury and nitrone radical scavengers on relative changes in regional cerebral blood flow and glucose uptake in rats
    Niklas Marklund
    Department of Neuroscience Neurosurgery, Uppsala University, Sweden
    J Neurotrauma 19:1139-53. 2002
    ..Thus, the early improvement in rCBF and glucose metabolism correlates with and may partly mediate the improved functional and morphological outcome after TBI in nitrone-treated rats...
  6. ncbi request reprint Monitoring of reactive oxygen species production after traumatic brain injury in rats with microdialysis and the 4-hydroxybenzoic acid trapping method
    N Marklund
    Department of Neuroscience and Neurosurgery, Clinical Chemistry at Uppsala University Hospital, Sweden
    J Neurotrauma 18:1217-27. 2001
    ..In addition, high cortical concentrations of 4-HBA and salicylate were found. It is concluded that microdialysis with 4-HBA as a trapping agent appears to be a useful method for ROS detection in the rat with a potential clinical utility...
  7. ncbi request reprint Free radical scavenger posttreatment improves functional and morphological outcome after fluid percussion injury in the rat
    N Marklund
    Department of Neuroscience and Neurosurgery, University Hospital, Uppsala, Sweden
    J Neurotrauma 18:821-32. 2001
    ..Our results suggest that nitrone radical scavengers are neuroprotective when administered 30 min after FPI in rats. Differences in pharmacokinetics may account for the observed individual neuroprotective profiles of the two nitrones...
  8. ncbi request reprint Neurointensive care management of raised intracranial pressure caused by severe valproic acid intoxication
    Niklas Marklund
    Department of Neuroscience, Uppsala University Hospital, Uppsala, 75185 Sweden
    Neurocrit Care 7:160-4. 2007
    ..The patient deteriorated to Glasgow Motor Scale score (GMS) 2 and a CT scan showed signs of raised ICP. Early ICP was elevated, >50 mm Hg, and continuous EEG monitoring showed isoelectric readings...
  9. pmc Selective temporal and regional alterations of Nogo-A and small proline-rich repeat protein 1A (SPRR1A) but not Nogo-66 receptor (NgR) occur following traumatic brain injury in the rat
    Niklas Marklund
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Neurol 197:70-83. 2006
    ....
  10. ncbi request reprint Energy metabolic changes in the early post-injury period following traumatic brain injury in rats
    Niklas Marklund
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, SE 75185 Uppsala, Sweden
    Neurochem Res 31:1085-93. 2006
    ..05). The energy-requiring secondary injury cascades that occur early post-injury do not challenge the brain tissue to the extent of ATP depletion and may provide a window of opportunity for therapeutic intervention...
  11. ncbi request reprint Low and high circulating cortisol levels predict mortality and cognitive dysfunction early after stroke
    N Marklund
    Department of Neuroscience and Neurosurgery, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
    J Intern Med 256:15-21. 2004
    ..The purpose of this study was to investigate serum cortisol and DS levels and the cortisol/DS ratio early after stroke and relate our findings to the presence of disorientation and mortality...
  12. ncbi request reprint Effects of the nitrone radical scavengers PBN and S-PBN on in vivo trapping of reactive oxygen species after traumatic brain injury in rats
    N Marklund
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Sweden
    J Cereb Blood Flow Metab 21:1259-67. 2001
    ..This finding supports an important role for ROS production at the blood-endothelial interface in TBI...
  13. ncbi request reprint Intracerebral microdialysis in neurointensive care: the use of urea as an endogenous reference compound
    E Ronne-Engstrom
    Department of Neuroscience, University Hospital, Uppsala, Sweden
    J Neurosurg 94:397-402. 2001
    ....
  14. ncbi request reprint Paradoxical increase in neuronal DNA fragmentation after neuroprotective free radical scavenger treatment in experimental traumatic brain injury
    A Lewen
    Department of Neuroscience, Division of Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    J Cereb Blood Flow Metab 21:344-50. 2001
    ..This should be considered in the screening process for future neuroprotective remedies...
  15. ncbi request reprint alpha-Phenyl-tert-N-butyl nitrone (PBN) improves functional and morphological outcome after cortical contusion injury in the rat
    N Marklund
    Department of Neurosurgery, Uppsala University Hospital, Sweden
    Acta Neurochir (Wien) 143:73-81. 2001
    ..05). Our results support the involvement of ROS in the injury process contributing to the tissue loss and cognitive disturbance after TBI. The potential clinical utility of PBN will have to be assessed using a post-injury dosing regime...
  16. ncbi request reprint Delayed inhibition of Nogo-A does not alter injury-induced axonal sprouting but enhances recovery of cognitive function following experimental traumatic brain injury in rats
    P M Lenzlinger
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, 105 Hayden Hall, 3320 Smith Walk, Philadelphia, PA 19104, USA
    Neuroscience 134:1047-56. 2005
    ....
  17. doi request reprint Ibuprofen attenuates the inflammatory response and allows formation of migratory neuroblasts from grafted stem cells after traumatic brain injury
    U Wallenquist
    Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden
    Restor Neurol Neurosci 30:9-19. 2012
    ..Neuroinflammation may lead to additional cell death after TBI and we hypothesized that survival of grafted NSPC could be enhanced by anti-inflammatory treatment...
  18. ncbi request reprint Experimental models of traumatic brain injury: do we really need to build a better mousetrap?
    D M Morales
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, 3320 Smith Walk, 105C Hayden Hall, Philadelphia, PA 19104, USA
    Neuroscience 136:971-89. 2005
    ..This review provides an up-to-date and critical analysis of the existing models of traumatic brain injury with a view toward guiding and improving future research endeavors...
  19. ncbi request reprint Changes in mACh, NMDA and GABA(A) receptor binding after lateral fluid-percussion injury: in vitro autoradiography of rat brain frozen sections
    S Sihver
    Department of Neuroscience, Unit of Pharmacology, Faculty of Medicine, University of Uppsala, Uppsala, Sweden
    J Neurochem 78:417-23. 2001
    ..The finding of a decreased BP demonstrates the involvement of these receptor systems in the development of cellular dysfunction, which is widespread and not limited to the site of lateral FPI...
  20. pmc TrkB gene transfer does not alter hippocampal neuronal loss and cognitive deficits following traumatic brain injury in mice
    Valeria Conte
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA
    Restor Neurol Neurosci 26:45-56. 2008
    ....
  21. ncbi request reprint Effects of the selective cyclooxygenase-2 inhibitor rofecoxib on cell death following traumatic brain injury in the rat
    Tina Kunz
    Department of Pharmaceutical Biosciences, Uppsala Biomedical Centre, Uppsala University, SE 751 24 Uppsala, Sweden
    Restor Neurol Neurosci 24:55-63. 2006
    ..The objective was to investigate whether the selective COX-2 inhibitor rofecoxib (10 mg/kg twice daily) reduces neuronal cell death after FPI in rats, since rofecoxib has been shown to be neuroprotective in other models of CNS injury...
  22. doi request reprint Myelin loss and oligodendrocyte pathology in white matter tracts following traumatic brain injury in the rat
    J Flygt
    Department of Neurosurgery, Uppsala University Hospital, Uppsala SE 751 85, Sweden
    Eur J Neurosci 38:2153-65. 2013
    ..Prevention of myelin loss and oligodendrocyte death may represent novel therapeutic targets for TBI. ..
  23. pmc Cognitive evaluation of traumatically brain-injured rats using serial testing in the Morris water maze
    Hilaire J Thompson
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, The University of Pennsylvania, Philadelphia, PA, USA
    Restor Neurol Neurosci 24:109-14. 2006
    ....
  24. doi request reprint The nitrone free radical scavenger NXY-059 is neuroprotective when administered after traumatic brain injury in the rat
    Fredrik Clausen
    Section for Neurosurgery, Department of Neuroscience, Uppsala University, Uppsala, Sweden
    J Neurotrauma 25:1449-57. 2008
    ..01). The results show that post-injury treatment with NXY-059 significantly attenuated the loss of injured brain tissue and improved cognitive outcome, suggesting a major role for ROS in the pathophysiology of TBI...
  25. ncbi request reprint Correlation of hippocampal morphological changes and morris water maze performance after cortical contusion injury in rats
    Fredrik Clausen
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    Neurosurgery 57:154-63; discussion 154-63. 2005
    ..We also analyzed the influence of pretreatment with the nitrone radical scavenger alpha-phenyl-N-tert-butyl-nitrone (PBN)...
  26. ncbi request reprint Cerebral glutamine and glutamate levels in relation to compromised energy metabolism: a microdialysis study in subarachnoid hemorrhage patients
    Carolina Samuelsson
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    J Cereb Blood Flow Metab 27:1309-17. 2007
    ....
  27. pmc Tissue sparing and functional recovery following experimental traumatic brain injury is provided by treatment with an anti-myelin-associated glycoprotein antibody
    Hilaire J Thompson
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, The University of Pennsylvania, Philadelphia, PA, USA, and Department of Neurosurgery, Uppsala University Hospital, Sweden
    Eur J Neurosci 24:3063-72. 2006
    ..05) when compared with their brain-injured controls. These results indicate that MAG may contribute to the pathophysiology of experimental TBI and treatment strategies that target MAG may be suitable for further evaluation...
  28. doi request reprint Clinical outcome following surgical treatment for bilateral cerebellar infarction
    P P Tsitsopoulos
    Department of Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    Acta Neurol Scand 123:345-51. 2011
    ..To analyze the initial clinical and radiological findings, the surgical treatment, and the clinical outcome following surgical decompression in patients with space-occupying bilateral cerebellar infarction...
  29. ncbi request reprint Early cerebral hyperglycolysis after subarachnoid haemorrhage correlates with favourable outcome
    K G Cesarini
    Department of Neuroscience, Section of Neurosurgery, Uppsala University, Uppsala, Sweden
    Acta Neurochir (Wien) 144:1121-31. 2002
    ..Intracerebral microdialysis (MD) was applied in patients with severe subarachnoid haemorrhage treated in a neurosurgical intensive care unit in order to explore their cerebral energy metabolism...
  30. doi request reprint Neutralization of interleukin-1beta modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice
    Fredrik Clausen
    Department of Neuroscience, Section for Neurosurgery, Uppsala University, Uppsala, Sweden
    Eur J Neurosci 30:385-96. 2009
    ....
  31. ncbi request reprint From cell death to neuronal regeneration: building a new brain after traumatic brain injury
    Nicolas C Royo
    Head Injury Center, Department of Neurosurgery University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 62:801-11. 2003
    ..These novel strategies may represent a new opportunity of great interest for delayed intervention in patients with TBI...
  32. ncbi request reprint Lateral fluid percussion brain injury: a 15-year review and evaluation
    Hilaire J Thompson
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 22:42-75. 2005
    ....
  33. ncbi request reprint Administration of monoclonal antibodies neutralizing the inflammatory mediators tumor necrosis factor alpha and interleukin -6 does not attenuate acute behavioral deficits following experimental traumatic brain injury in the rat
    Niklas Marklund
    Traumatic Brain Injury Labraty, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Restor Neurol Neurosci 23:31-42. 2005
    ..We evaluated the effects of monoclonal antibodies (mAB), neutralizing either IL-6 (IL-6 mAB) or TNF-alpha (TNF mAB), administered intracerebroventricularly (i.c.v) on acute neurobehavioral outcome following TBI...
  34. ncbi request reprint Evaluation of pharmacological treatment strategies in traumatic brain injury
    Niklas Marklund
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, USA
    Curr Pharm Des 12:1645-80. 2006
    ....
  35. doi request reprint Effects of the neurological wake-up test on intracranial pressure and cerebral perfusion pressure in brain-injured patients
    Karin Skoglund
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, 751 85 Uppsala, Sweden
    Neurocrit Care 11:135-42. 2009
    ....
  36. ncbi request reprint Assessment of the effects of the cyclooxygenase-2 inhibitor rofecoxib on visuospatial learning and hippocampal cell death following kainate-induced seizures in the rat
    Tina Kunz
    Department of Pharmaceutical Biosciences, Uppsala Biomedical Centre, Uppsala University, SE 751 24 Uppsala, Sweden
    Brain Res Cogn Brain Res 25:826-32. 2005
    ....
  37. ncbi request reprint Cyclooxygenase-2, prostaglandin synthases, and prostaglandin H2 metabolism in traumatic brain injury in the rat
    Tina Kunz
    Department of Pharmaceutical Biosciences, Uppsala Biomedical Center, Uppsala University, Uppsala, Sweden
    J Neurotrauma 19:1051-64. 2002
    ....
  38. ncbi request reprint Activation of Rho after traumatic brain injury and seizure in rats
    Catherine I Dubreuil
    Universite de Montreal, 2900 Edouard Montpetit, Faculte de Medecine, Departement de pathologie et biologie cellulaire, Montreal, QC, Canada H3T 1J4
    Exp Neurol 198:361-9. 2006
    ..Severe seizures resulted in bilateral RhoA activation in the cortex and hippocampus. Together, these results indicate that RhoA is activated in vulnerable brain regions following traumatic and epileptic insults to the CNS...