Research Topics
Species | Hans LithellSummaryAffiliation: Uppsala University Country: Sweden Publications
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Publications
The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trialHans Lithell
Department of Public Health and Caring Sciences, Sections of Geriatrics Clinical Hypertension Research and Family Medicine, University of Uppsala, Uppsala, Sweden
J Hypertens 21:875-86. 2003..The prognostic benefits of blood pressure lowering treatment in elderly hypertensive patients were established more than a decade ago, but are less clear in those with mildly to moderately elevated blood pressure...- The Study on COgnition and Prognosis in the Elderly (SCOPE); outcomes in patients not receiving add-on therapy after randomizationHans Lithell
Department of Public Health and Caring Sciences, Section of Geriatrics, University of Uppsala, Sweden
J Hypertens 22:1605-12. 2004..e. in patients that best reflect the original intention of a placebo-controlled trial... - Insulin resistance, dietary fat intake and blood pressure predict left ventricular diastolic function 20 years laterJohan Arnlov
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
Nutr Metab Cardiovasc Dis 15:242-9. 2005.... - Evaluation of a scoring scheme, including proinsulin and the apolipoprotein B/apolipoprotein A1 ratio, for the risk of acute coronary events in middle-aged men: Uppsala Longitudinal Study of Adult Men (ULSAM)Kristina Dunder
Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
Am Heart J 148:596-601. 2004.... - The majority of nondipping men do not have increased cardiovascular risk: a population-based studyKristina Björklund
Department of Public Health and Caring Sciences Section of Geriatrics, University of Uppsala, Uppsala, Sweden
J Hypertens 20:1501-6. 2002..To investigate whether nondipping and diabetes are independently related to metabolic risk profile and prevalence of target organ damage in a population setting... - Prognostic significance of 24-h ambulatory blood pressure characteristics for cardiovascular morbidity in a population of elderly menKristina Björklund
Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden
J Hypertens 22:1691-7. 2004..This study aimed to investigate the prognostic significance of 24-h ambulatory systolic (SBP), diastolic (DBP) and pulse pressure (PP), and blood pressure (BP) variability for cardiovascular morbidity in elderly men... - Cardiovascular risk factors for stable angina pectoris versus unheralded myocardial infarctionKristina Dunder
Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
Am Heart J 147:502-8. 2004..This study compared baseline risk factors between subjects in whom stable angina pectoris developed and subjects in whom unheralded fatal or nonfatal MI developed during the follow-up period... - A Doppler-derived index of combined left ventricular systolic and diastolic function is an independent predictor of cardiovascular mortality in elderly menJohan Arnlov
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
Am Heart J 149:902-7. 2005..The novel myocardial performance index (MPI, also denoted as Tei-Doppler index) has been suggested to reflect both left ventricular (LV) systolic and diastolic function... - Isolated ambulatory hypertension predicts cardiovascular morbidity in elderly menKristina Björklund
Department of Public Health and Caring Sciences Section of Geriatrics, Uppsala University, Uppsala, Sweden
Circulation 107:1297-302. 2003..This study aimed to investigate the prognostic significance of isolated ambulatory hypertension for cardiovascular morbidity in a population of elderly men... - Smoking and the risk of fracture in older menHelena Olofsson
Section of Orthopedics, Department of Surgical Sciences, University Hospital, Uppsala, Sweden
J Bone Miner Res 20:1208-15. 2005..CONCLUSIONS: Tobacco smoking seems to be a long-lasting major risk factor for fracture in older men, and the risks depends both on recency of smoking and on the daily amount of tobacco smoked, rather than smoking duration... - hUNC-93B1, a novel gene mainly expressed in the heart, is related to left ventricular diastolic function, heart failure morbidity and mortality in elderly menJohan Arnlov
Department of Public Health and Caring Sciences Geriatrics, PO Box 609, S 75125 Uppsala, Sweden
Eur J Heart Fail 7:958-65. 2005..The hUNC-93B1 gene has the highest expression in the heart. We aimed to explore relationships between the hUNC-93B1 gene and cardiac function, morbidity and mortality in elderly men... - Evaluation and application of the General Motor Function assessment scale in geriatric rehabilitationAnna Cristina Aberg
Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden
Disabil Rehabil 25:360-8. 2003..To test General Motor Function assessment scale (GMF) for concurrent validity, to analyse the distribution of scores and its clinical sensitivity in a setting of geriatric rehabilitation... - Development and reliability of the General Motor Function Assessment Scale (GMF)--a performance-based measure of function-related dependence, pain and insecurityAnna Cristina Aberg
Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, PO Box 609 S 751 25, Uppsala, Sweden
Disabil Rehabil 25:462-72. 2003.... - Magnesium infusion improves endothelium-dependent vasodilation in the human forearmArvo Haenni
Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Sweden
Am J Hypertens 15:10-5. 2002..In conclusion, this in vivo study showed that intraarterial magnesium infusion increased EDV in the infused human forearm, which is in accordance with findings in previous in vitro and animal experiments... 
Increase in blood glucose concentration during antihypertensive treatment as a predictor of myocardial infarction: population based cohort studyKristina Dunder
Department of Public Health and Caring Sciences Geriatrics, Uppsala University, PO Box 609, SE 751 25 Uppsala, Sweden
BMJ 326:681. 2003..To investigate the impact of an increase in blood glucose on the risk of developing myocardial infarction, with particular emphasis on people taking antihypertensive drugs...- Skeletal muscle magnesium content is correlated with plasma glucose concentration in patients with essential hypertension treated with lisinopril or bendrofluazideArvo Haenni
Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Sweden
Am J Hypertens 15:735-8. 2002..However, the Mg concentration in skeletal muscle did not significantly predict the insulin sensitivity or glucose tolerance... - Proinsulin is an independent predictor of coronary heart disease: Report from a 27-year follow-up studyBjorn Zethelius
Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Sweden
Circulation 105:2153-8. 2002.... - Serum retinol levels and the risk of fractureKarl Michaelsson
Department of Surgical Sciences, Section of Orthopedics, University Hospital, Uppsala, Sweden
N Engl J Med 348:287-94. 2003.... - Different metabolic predictors of white-coat and sustained hypertension over a 20-year follow-up period: a population-based study of elderly menKristina Björklund
Department of Public Health and Caring Sciences Section of Geriatrics, University of Uppsala, Sweden
Circulation 106:63-8. 2002..The clinical significance of white-coat hypertension is still unclear. Moreover, no study has examined metabolic predictors of white-coat versus sustained hypertension... - On loss of activity and independence, adaptation improves life satisfaction in old age--a qualitative study of patients' perceptionsAnna Cristina Aberg
Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Sweden
Qual Life Res 14:1111-25. 2005..Strategies for improving life satisfaction among old people in rehabilitation are suggested... - Acute elevations of medium- and long-chain fatty acid have different impacts on endothelium-dependent vasodilation in humansPeter Steer
Department of Medical Sciences Internal Medicine, University Hospital, SE 751 85 Uppsala, Sweden
Lipids 38:15-9. 2003..05). In conclusion, an acute elevation of LCFA attenuated EDV, whereas an elevation of both MCFA and LCFA did not influence EDV. Thus, FA composition seems to be of importance for EDV in healthy humans... - Effect of baseline cognitive function and antihypertensive treatment on cognitive and cardiovascular outcomes: Study on COgnition and Prognosis in the Elderly (SCOPE)Ingmar Skoog
Institute of Clinical Neurosciences, Neuropsychiatric Epidemiology Unit, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
Am J Hypertens 18:1052-9. 2005..We examined whether cognitive function at baseline affected cognitive and cardiovascular outcomes in the Study on COgnition and Prognosis in the Elderly (SCOPE), a blood pressure (BP)-lowering intervention trial... - Insulin-mediated vasodilatation, but not glucose uptake or endothelium-mediated vasodilatation, is enhanced in young females compared with malesLars Lind
Department of Internal Medicine, University Hospital, S-751 85 Uppsala, Sweden
Clin Sci (Lond) 102:241-6. 2002..However, no differences between the sexes were seen with regard to insulin-mediated glucose uptake and the ability of insulin to enhance endothelium-dependent vasodilatation... - Fetal, developmental, and parental influences on childhood systolic blood pressure in 600 sib pairs: the Uppsala Family studyDavid A Leon
London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Circulation 112:3478-85. 2005..A study of within- and between-family associations of birth weight with blood pressure, which collected data on both parents, would address this gap in our knowledge... - The Study on COgnition and Prognosis in the Elderly (SCOPE) - major CV events and stroke in subgroups of patientsPeter Trenkwalder
Department of Internal Medicine, Starnberg Hospital, Ludwig Maximilian University Munich, Osswaldstrasse 1, D 82319 Starnberg, Germany
Blood Press 14:31-7. 2005..However, the benefit was particularly pronounced in patients who entered the study with a previous stroke... - Cognitive function and health-related quality of life in elderly patients with hypertension--baseline data from the study on cognition and prognosis in the elderly (SCOPE)Alessio degl'Innocenti
AstroZeneca R and D, Molndal, Sweden
Blood Press 11:157-65. 2002..Age and the use of psychotropic drugs, but not gender and education level, influenced this relationship significantly... - Stroke prevention with the angiotensin II type 1-receptor blocker candesartan in elderly patients with isolated systolic hypertension: the Study on Cognition and Prognosis in the Elderly (SCOPE)Vasilios Papademetriou
Hypertension and Cardiovascular Research, Veterans Administration Medical Center, Washington, DC 20422, USA
J Am Coll Cardiol 44:1175-80. 2004..The aim of this study was to test the hypothesis that the angiotensin II type 1 receptor blocker (ARB) candesartan can reduce the risk of stroke in elderly patients with isolated systolic hypertension (ISH)... - Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian CaucasiansSøren K Rasmussen
Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
Diabetes 51:3561-7. 2002.... - Continuity of the self in later life: perceptions of informal caregiversAnna C Aberg
Uppsala University, Sweden
Qual Health Res 14:792-815. 2004..This study underscores the value of informal caregiving and that the caregiving interaction should be balanced by reciprocity... - The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart diseaseHelena Ledmyr
King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
Circulation 109:2279-84. 2004..We hypothesize that this polymorphism impacts on coronary heart disease (CHD) risk... - Vitamin C, diclophenac, and L-arginine protect endothelium-dependent vasodilation against elevated circulating fatty acid levels in humansPeter Steer
Department of Medical Sciences Internal Medicine, University Hospital, SE 75185 Uppsala, Sweden
Atherosclerosis 168:65-72. 2003..Administration of L-arginine, vitamin C or COX inhibition abolished this effect, suggesting that NEFAs might interact with endothelial vasodilatory function through multiple mechanisms... - Normalized dyslipidaemia after parathyroidectomy in mild primary hyperparathyroidism: population-based study over five yearsEmil Hagström
Department of Surgery, Uppsala University Hospital and AstraZeneca R and D, Molndal, Sweden
Clin Endocrinol (Oxf) 56:253-60. 2002..Secondary dyslipidaemia in pHPT has attracted little attention, although morbidity and mortality associated with cardiovascular diseases have been reported to be increased in these patients... - [Pharmacogenetics--pathway to individualized antihypertensive pharmacotherapy]Lisa Kurland
Medicincentrum, Akademiska sjukhuset, Uppsala
Lakartidningen 100:600-3. 2003..The article gives a background to the field, with emphasis on antihypertensive therapy, and prospects for the future... - Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort studyJohan Sundstrom
Department of Medical Sciences, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
BMJ 332:878-82. 2006..To find out if the presence of the metabolic syndrome increases the risk of subsequent total and cardiovascular mortality, taking into account established risk factors for cardiovascular disease...