Cecilia K Lindholm

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. ncbi Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells
    Cecilia K Lindholm
    Department of Medical Cell Biology, Box 571, Biomedicum, Uppsala University, 75123 Uppsala, Sweden
    Eur J Biochem 269:3279-88. 2002
  2. ncbi IL-2 receptor signaling through the Shb adapter protein in T and NK cells
    Cecilia K Lindholm
    Department of Medical Cell Biology, Uppsala University, Biomedicum, Box 571, S 75123 Uppsala, Sweden
    Biochem Biophys Res Commun 296:929-36. 2002
  3. ncbi The SHB adapter protein is required for normal maturation of mesoderm during in vitro differentiation of embryonic stem cells
    Vitezslav Kriz
    Department of Medical Cell Biology, Uppsala University, Uppsala 75123, Sweden
    J Biol Chem 281:34484-91. 2006
  4. ncbi The FRK/RAK-SHB signaling cascade: a versatile signal-transduction pathway that regulates cell survival, differentiation and proliferation
    Cecilia Annerén
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA
    Curr Mol Med 3:313-24. 2003
  5. pmc Ubiquitylation of a melanosomal protein by HECT-E3 ligases serves as sorting signal for lysosomal degradation
    Frédéric Lévy
    Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland
    Mol Biol Cell 16:1777-87. 2005

Collaborators

  • Michael Welsh
  • Johan Saldeen
  • D Rimoldi
  • Vitezslav Kriz
  • Frédéric Lévy
  • Cecilia Annerén
  • Samuel Lenell
  • Jaroslav Mares
  • Nina Agren
  • Jean Charles Cerottini
  • Suzanne Salvi
  • Katja Muehlethaler
  • Anne Lise Peitrequin

Detail Information

Publications5

  1. ncbi Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells
    Cecilia K Lindholm
    Department of Medical Cell Biology, Box 571, Biomedicum, Uppsala University, 75123 Uppsala, Sweden
    Eur J Biochem 269:3279-88. 2002
    ..Our results indicate that upon TCR stimulation, Shb is targeted to these lipid rafts where Shb aids in recruiting the SLP-76-Gads-Vav complex to the T cell receptor zeta-chain and ZAP70...
  2. ncbi IL-2 receptor signaling through the Shb adapter protein in T and NK cells
    Cecilia K Lindholm
    Department of Medical Cell Biology, Uppsala University, Biomedicum, Box 571, S 75123 Uppsala, Sweden
    Biochem Biophys Res Commun 296:929-36. 2002
    ..In conclusion, Shb links the IL-2 receptor to other signaling proteins and mediates the regulation of apoptosis in the presence of IL-2...
  3. ncbi The SHB adapter protein is required for normal maturation of mesoderm during in vitro differentiation of embryonic stem cells
    Vitezslav Kriz
    Department of Medical Cell Biology, Uppsala University, Uppsala 75123, Sweden
    J Biol Chem 281:34484-91. 2006
    ..It is concluded that SHB is required for appropriate hematopoietic and vascular differentiation and that delayed down-regulation of Brachyury expression may play a role in this context...
  4. ncbi The FRK/RAK-SHB signaling cascade: a versatile signal-transduction pathway that regulates cell survival, differentiation and proliferation
    Cecilia Annerén
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA
    Curr Mol Med 3:313-24. 2003
    ..In summary, SHB is a versatile signal transduction molecule that produces diverse biological responses in different cell types under various conditions. SHB operates downstream of GTK in cells that express this kinase...
  5. pmc Ubiquitylation of a melanosomal protein by HECT-E3 ligases serves as sorting signal for lysosomal degradation
    Frédéric Lévy
    Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland
    Mol Biol Cell 16:1777-87. 2005
    ..These results suggest that ubiquitylation regulates the lysosomal sorting and degradation of Melan-A/MART-1 from melanosomes in melanocytic cells...