Bertil Lindahl

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. ncbi request reprint Diagnosis and management of patients with suspected acute myocardial infarction
    Bertil Lindahl
    Department of Cardiology and Uppsala Clinical Research Center, University of Uppsala, Sweden
    Scand J Clin Lab Invest Suppl 240:93-8. 2005
  2. ncbi request reprint Diagnostic applications of natriuretic peptides in ischemic heart disease
    Bertil Lindahl
    University Hospital of Uppsala, Uppsala, Sweden
    Heart Fail Clin 2:311-21. 2006
  3. ncbi request reprint Serial analyses of N-terminal pro-B-type natriuretic peptide in patients with non-ST-segment elevation acute coronary syndromes: a Fragmin and fast Revascularisation during In Stability in Coronary artery disease (FRISC)-II substudy
    Bertil Lindahl
    Department of Medical Sciences and Cardiology, Uppsala Clinical Research Center, University Hospital, Uppsala, Sweden
    J Am Coll Cardiol 45:533-41. 2005
  4. doi request reprint Improving long-term risk prediction in patients with acute chest pain: the Global Registry of Acute Coronary Events (GRACE) risk score is enhanced by selected nonnecrosis biomarkers
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
    Am Heart J 160:88-94. 2010
  5. ncbi request reprint N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease: a Global Utilization of Strategies To Open occluded arteries (
    Stefan K James
    Department of Medical Sciences, Cardiology, University of Uppsala, Uppsala, Sweden
    Circulation 108:275-81. 2003
  6. ncbi request reprint Troponin-T and N-terminal pro-B-type natriuretic peptide predict mortality benefit from coronary revascularization in acute coronary syndromes: a GUSTO-IV substudy
    Stefan K James
    Uppsala Clinical Research Center, Uppsala, Sweden
    J Am Coll Cardiol 48:1146-54. 2006
  7. ncbi request reprint Usefulness of biomarkers for predicting long-term mortality in patients with diabetes mellitus and non-ST-elevation acute coronary syndromes (a GUSTO IV substudy)
    Stefan K James
    Department of Medical Sciences and Cardiology, Academic Hospital, Uppsala, Sweden
    Am J Cardiol 97:167-72. 2006
  8. ncbi request reprint N-terminal pro-brain natriuretic peptide in relation to inflammation, myocardial necrosis, and the effect of an invasive strategy in unstable coronary artery disease
    Tomas Jernberg
    Department of Medical Sciences, Cardiology, Cardiothoracic Center, University Hospital, Uppsala, Sweden
    J Am Coll Cardiol 42:1909-16. 2003
  9. ncbi request reprint Cystatin C: a novel predictor of outcome in suspected or confirmed non-ST-elevation acute coronary syndrome
    Tomas Jernberg
    Department of Medical Sciences, Cardiology, Uppsala Research Center, University Hospital, 751 85 Uppsala, Sweden
    Circulation 110:2342-8. 2004
  10. ncbi request reprint Troponin T levels and risk of 30-day outcomes in patients with the acute coronary syndrome: prospective verification in the GUSTO-IV trial
    Stefan James
    Department of Cardiology, Uppsala University Hospital, Uppsala, Sweden
    Am J Med 115:178-84. 2003

Detail Information

Publications82

  1. ncbi request reprint Diagnosis and management of patients with suspected acute myocardial infarction
    Bertil Lindahl
    Department of Cardiology and Uppsala Clinical Research Center, University of Uppsala, Sweden
    Scand J Clin Lab Invest Suppl 240:93-8. 2005
    ..Several different risk scoring models based on a combination of clinical variables, ECG-changes and biochemical markers, have been shown to further improve risk assessment and selection of treatment...
  2. ncbi request reprint Diagnostic applications of natriuretic peptides in ischemic heart disease
    Bertil Lindahl
    University Hospital of Uppsala, Uppsala, Sweden
    Heart Fail Clin 2:311-21. 2006
  3. ncbi request reprint Serial analyses of N-terminal pro-B-type natriuretic peptide in patients with non-ST-segment elevation acute coronary syndromes: a Fragmin and fast Revascularisation during In Stability in Coronary artery disease (FRISC)-II substudy
    Bertil Lindahl
    Department of Medical Sciences and Cardiology, Uppsala Clinical Research Center, University Hospital, Uppsala, Sweden
    J Am Coll Cardiol 45:533-41. 2005
    ....
  4. doi request reprint Improving long-term risk prediction in patients with acute chest pain: the Global Registry of Acute Coronary Events (GRACE) risk score is enhanced by selected nonnecrosis biomarkers
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
    Am Heart J 160:88-94. 2010
    ..However, there is limited knowledge regarding the utility of this score for long-term risk prediction in unselected patients with acute chest pain and whether it might be improved by the integration of nonnecrosis biomarkers...
  5. ncbi request reprint N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease: a Global Utilization of Strategies To Open occluded arteries (
    Stefan K James
    Department of Medical Sciences, Cardiology, University of Uppsala, Uppsala, Sweden
    Circulation 108:275-81. 2003
    ....
  6. ncbi request reprint Troponin-T and N-terminal pro-B-type natriuretic peptide predict mortality benefit from coronary revascularization in acute coronary syndromes: a GUSTO-IV substudy
    Stefan K James
    Uppsala Clinical Research Center, Uppsala, Sweden
    J Am Coll Cardiol 48:1146-54. 2006
    ..This study was designed to evaluate biomarkers for selection of patients with non-ST-segment elevation acute coronary syndromes (ACS) that derive mortality benefit from revascularization...
  7. ncbi request reprint Usefulness of biomarkers for predicting long-term mortality in patients with diabetes mellitus and non-ST-elevation acute coronary syndromes (a GUSTO IV substudy)
    Stefan K James
    Department of Medical Sciences and Cardiology, Academic Hospital, Uppsala, Sweden
    Am J Cardiol 97:167-72. 2006
    ..Despite a larger proportion of ST depression and increased levels of NT-pro-BNP and interleukin-6 at admission, these factors provide independent prognostic information that may improve risk stratification and guidance of treatment...
  8. ncbi request reprint N-terminal pro-brain natriuretic peptide in relation to inflammation, myocardial necrosis, and the effect of an invasive strategy in unstable coronary artery disease
    Tomas Jernberg
    Department of Medical Sciences, Cardiology, Cardiothoracic Center, University Hospital, Uppsala, Sweden
    J Am Coll Cardiol 42:1909-16. 2003
    ....
  9. ncbi request reprint Cystatin C: a novel predictor of outcome in suspected or confirmed non-ST-elevation acute coronary syndrome
    Tomas Jernberg
    Department of Medical Sciences, Cardiology, Uppsala Research Center, University Hospital, 751 85 Uppsala, Sweden
    Circulation 110:2342-8. 2004
    ..Cystatin C is a new and better marker of renal function than creatinine. The aim was therefore to evaluate the prognostic value of cystatin C in this population...
  10. ncbi request reprint Troponin T levels and risk of 30-day outcomes in patients with the acute coronary syndrome: prospective verification in the GUSTO-IV trial
    Stefan James
    Department of Cardiology, Uppsala University Hospital, Uppsala, Sweden
    Am J Med 115:178-84. 2003
    ..However, the appropriate cutoff for identifying patients with the acute coronary syndrome who are at low risk of subsequent mortality has not been established...
  11. pmc Growth-differentiation factor-15 for early risk stratification in patients with acute chest pain
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital, Uppsala, Sweden
    Eur Heart J 29:2327-35. 2008
    ..We explored the usefulness of GDF-15 for early risk stratification in 479 unselected patients with acute chest pain...
  12. doi request reprint Pathophysiologic mechanisms of persistent cardiac troponin I elevation in stabilized patients after an episode of acute coronary syndrome
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital, Uppsala, Sweden
    Am Heart J 156:588-94. 2008
    ..We now have studied the associations of persistently elevated cTnI levels to cardiac performance, inflammation, coagulation, coronary status, and treatment strategy in these patients...
  13. ncbi request reprint A rapid troponin I assay is not optimal for determination of troponin status and prediction of subsequent cardiac events at suspicion of unstable coronary syndromes
    Stefan K James
    Department of Medical Sciences, Cardiology, Uppsala, Sweden
    Int J Cardiol 93:113-20. 2004
    ..Troponin is a specific marker of myocardial damage. For early prediction of coronary events in patients with suspicion of acute coronary syndromes the assay also needs to be highly sensitive...
  14. ncbi request reprint Effects of an early invasive strategy on ischemia and exercise tolerance among patients with unstable coronary artery disease
    Erik Diderholm
    Department of Cardiology, University Hospital, Uppsala, Sweden
    Am J Med 115:606-12. 2003
    ..An early invasive approach after an episode of unstable coronary artery disease has beneficial effects on mortality and myocardial infarction, but its effects on exercise capacity and ischemia have not been investigated...
  15. doi request reprint Growth-differentiation factor-15 is an independent marker of cardiovascular dysfunction and disease in the elderly: results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) Study
    Lars Lind
    Department of Medicine Cardiology and Clinical Chemistry, University of Uppsala, 75185 Uppsala, Sweden
    Eur Heart J 30:2346-53. 2009
    ..Little is known about the pathophysiological basis for the close association of GDF-15 to future CV events. We hypothesized that GDF-15 is related to underlying CV pathologies...
  16. ncbi request reprint NT-proBNP in unstable coronary artery disease--experiences from the FAST, GUSTO IV and FRISC II trials
    Tomas Jernberg
    Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, University Hospital, Uppsala 751 85, Sweden
    Eur J Heart Fail 6:319-25. 2004
    ..e. unstable angina or non-ST-elevation myocardial infarction. This article focuses on the emerging role of N-terminal pro brain natriuretic peptide (NT-proBNP) and the results from the FAST, GUSTO IV and FRISC II trials...
  17. doi request reprint Cardiac troponin I levels measured with a high-sensitive assay increase over time and are strong predictors of mortality in an elderly population
    Kai M Eggers
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Am Coll Cardiol 61:1906-13. 2013
    ..This study sought to assess changes in troponin levels, underlying conditions, and the prognostic implications in elderly subjects from the community...
  18. doi request reprint Prognostic value of biomarkers during and after non-ST-segment elevation acute coronary syndrome
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Centre, Uppsala, Sweden
    J Am Coll Cardiol 54:357-64. 2009
    ..The aim of this study was to assess risk prediction by different biomarkers in patients with an ongoing non-ST-segment elevation acute coronary syndrome (NSTE-ACS) and after clinical stabilization...
  19. doi request reprint Growth-differentiation factor-15 for long-term risk prediction in patients stabilized after an episode of non-ST-segment-elevation acute coronary syndrome
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
    Circ Cardiovasc Genet 3:88-96. 2010
    ..This study assessed the time course and the long-term prognostic relevance of GDF-15 levels measured repetitively in patients with non-ST-segment-elevation acute coronary syndrome during 6 months after the acute event...
  20. ncbi request reprint The prognostic and therapeutic implications of increased troponin T levels and ST depression in unstable coronary artery disease: the FRISC II invasive troponin T electrocardiogram substudy
    Erik Diderholm
    Department of Cardiology, University Hospital, Uppsala, Sweden
    Am Heart J 143:760-7. 2002
    ....
  21. ncbi request reprint Combining different biochemical markers of myocardial ischemia does not improve risk stratification in chest pain patients compared to troponin I alone
    Kai M Eggers
    Department of Cardiology, University Hospital, Uppsala, Sweden
    Coron Artery Dis 16:315-9. 2005
    ..A multimarker strategy applying results of early measurements of different biochemical markers of cardiac necrosis in combination may improve risk prediction in chest pain patients...
  22. ncbi request reprint Biochemical indicators of cardiac and renal function in a healthy elderly population
    Nina Johnston
    Department of Medical Sciences, Cardiology, University Hospital, Uppsala, Sweden
    Clin Biochem 37:210-6. 2004
    ..To examine the distributions of NT-proBNP and cystatin C and their relation to age, gender, and other physiological factors in an apparently healthy elderly population...
  23. ncbi request reprint Risk prediction in patients with chest pain: early assessment by the combination of troponin I results and electrocardiographic findings
    Kai M Eggers
    Department of Cardiology, University Hospital, Uppsala, Sweden
    Coron Artery Dis 16:181-9. 2005
    ..To evaluate the prognostic value of point of care troponin I (TnI) results in combination with findings from the admission electrocardiogram (ECG) in patients with chest pain...
  24. ncbi request reprint Outcome of ST-elevation myocardial infarction treated with thrombolysis in the unselected population is vastly different from samples of eligible patients in a large-scale clinical trial
    Erik Bjorklund
    Department of Cardiology, Thoraxcenter, University Hospital, Uppsala, Sweden
    Am Heart J 148:566-73. 2004
    ..However, a direct comparison of patients treated with fibrinolytic agents and not enrolled versus those enrolled in a trial, including a large number of patients, has not been performed...
  25. ncbi request reprint Prehospital diagnosis and start of treatment reduces time delay and mortality in real-life patients with STEMI
    Erik Bjorklund
    Department of Cardiology, University Hospital, Uppsala, Sweden
    J Electrocardiol 38:186. 2005
  26. ncbi request reprint N-terminal pro brain natriuretic peptide on admission for early risk stratification of patients with chest pain and no ST-segment elevation
    Tomas Jernberg
    Department of Medical Sciences, Cardiology, University Hospital, Uppsala, Sweden
    J Am Coll Cardiol 40:437-45. 2002
    ..The study evaluated the prognostic value of single measurement of N-terminal pro brain natriuretic peptide (NT-proBNP) obtained on admission in patients with symptoms suggestive of an acute coronary syndrome and no ST-segment elevation...
  27. doi request reprint Normal plasma levels of cardiac troponin I measured by the high-sensitivity cardiac troponin I access prototype assay and the impact on the diagnosis of myocardial ischemia
    Per Venge
    Department of Medical Sciences, University of Uppsala, Sweden
    J Am Coll Cardiol 54:1165-72. 2009
    ..This study sought to evaluate the analytical and clinical performance of the novel hypersensitive cardiac troponin I (cTnI) prototype assay from Beckman Coulter (Fullerton, California)...
  28. ncbi request reprint Comparison between second and third generation troponin T assay in patients with symptoms suggestive of an acute coronary syndrome but without ST segment elevation
    Tomas Jernberg
    Department of Medical Sciences, Cardiology, University Hospital, Uppsala, Sweden
    Cardiology 100:29-35. 2003
    ..02 microg/l) and thereby an increased risk of future events. We conclude that the improved precision of the 3rd generation assay does have some clinical implications in terms of improved accuracy of triage and improved prognostic value...
  29. doi request reprint Myeloperoxidase is not useful for the early assessment of patients with chest pain
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
    Clin Biochem 43:240-5. 2010
    ..Myeloperoxidase (MPO) has been listed as a potentially useful risk marker in acute coronary syndrome. However, its clinical utility in patients with acute chest pain is not yet defined...
  30. doi request reprint Improved clinical outcome after acute myocardial infarction in hospitals participating in a Swedish quality improvement initiative
    Rickard Carlhed
    Department of Cardiology and Uppsala Clinical Research Center, University Hospital, Uppsala, Sweden
    Circ Cardiovasc Qual Outcomes 2:458-64. 2009
    ..The associated impact on 1-year clinical outcome is presented here...
  31. doi request reprint A novel approach to cardiac troponins to improve the diagnostic work-up in chest pain patients
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden
    Crit Pathw Cardiol 11:199-205. 2012
    ..This could facilitate the early diagnostic work-up of chest pain patients, thereby improving patient flow and reducing overcrowding in healthcare facilities...
  32. ncbi request reprint The antibody configurations of cardiac troponin I assays may determine their clinical performance
    Stefan James
    Department of Medical Sciences, Cardiology, Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Clin Chem 52:832-7. 2006
    ..The approach has been adopted by the new cTnI assay from Abbott Diagnostics. The aim of our study was to investigate whether this approach affects the clinical performance of cTnI assays...
  33. ncbi request reprint Admission Troponin T and measurement of ST-segment resolution at 60 min improve early risk stratification in ST-elevation myocardial infarction
    Erik Bjorklund
    Department of Cardiology, University Hospital of Uppsala, Sweden
    Eur Heart J 25:113-20. 2004
    ..However, the combination of these two early available markers for predicting risk has not been evaluated...
  34. ncbi request reprint A combination of troponin T and 12-lead electrocardiography: a valuable tool for early prediction of long-term mortality in patients with chest pain without ST-segment elevation
    Tomas Jernberg
    Department of Cardiology, Cardiothoracic Center, University Hospital, Uppsala, Sweden
    Am Heart J 144:804-10. 2002
    ..However, there are few studies about the combination of these 2 methods as a means of predicting long-term outcome...
  35. ncbi request reprint Clinical and analytical performance of the liaison cardiac troponin I assay in unstable coronary artery disease, and the impact of age on the definition of reference limits. A FRISC-II substudy
    Per Venge
    Department of Medical Sciences, University of Uppsala, SE 751 85 Uppsala, Sweden
    Clin Chem 49:880-6. 2003
    ..Our aim was to evaluate the clinical and analytical performance of the Liaison cardiac troponin I (cTnI) assay...
  36. ncbi request reprint Non-dipolar content of the T-wave as a measure of repolarization inhomogeneity in ST-elevation myocardial infarction
    Milos Kesek
    Department of Cardiology, Heart Centre, University Hospital, Umea, Sweden
    Clin Physiol Funct Imaging 26:362-70. 2006
    ..Resolution of the ST-elevation is associated with a decrease. The increased non-dipolar content reflects a property of the repolarization phase, which is related to but separated from the ST-elevation...
  37. doi request reprint Plasma prolylcarboxypeptidase (angiotensinase C) is increased in obesity and diabetes mellitus and related to cardiovascular dysfunction
    Shengyuan Xu
    Section of Clinical Chemistry, Department of Medical Sciences, University of Uppsala, Uppsala, Sweden
    Clin Chem 58:1110-5. 2012
    ..The objectives of this study were to purify PRCP from a native source, establish a sensitive immunoassay for PRCP, and relate plasma PRCP concentrations to signs and symptoms of obesity, diabetes mellitus, and cardiovascular dysfunction...
  38. ncbi request reprint Digoxin and mortality in atrial fibrillation: a prospective cohort study
    Par Hallberg
    Department of Medical Sciences, Clinical Pharmacology, Uppsala University Hospital, Uppsala University, 751 85, Uppsala, Sweden
    Eur J Clin Pharmacol 63:959-71. 2007
    ..No study has investigated a priori the effect of digoxin on mortality in patients with AF. This study aimed to address this question...
  39. doi request reprint Early and late outcome prediction of death in the emergency room setting by point-of-care and laboratory assays of cardiac troponin I
    Per Venge
    Department of Medical Sciences, Clinical Chemistry, University of Uppsala, Uppsala, Sweden
    Am Heart J 160:835-41. 2010
    ..The question raised was as follows: What is the clinical impact of the results of POC assays of cardiac troponins as compared with sensitive laboratory assays?..
  40. ncbi request reprint Observer variability and optimal criteria of transient ischemia during ST monitoring with continuous 12-lead ECG
    Tomas Jernberg
    Department of Cardiology, Cardiothoracic Center, University Hospital, 751 85 Uppsala, Sweden
    Ann Noninvasive Electrocardiol 7:181-90. 2002
    ..However, the method lacks documentation on optimal criteria for episodes of transient ischemia and on observer variability...
  41. doi request reprint The new high-sensitivity cardiac troponin T assay improves risk assessment in acute coronary syndromes
    Bertil Lindahl
    Department of Medical Sciences, Cardiology, and Uppsala Clinical Research Center, University of Uppsala, Uppsala, Sweden
    Am Heart J 160:224-9. 2010
    ..However, how the hs-cTnT assay compares with the old cTnT assay for risk assessment in ACS is still unknown...
  42. doi request reprint B-type natriuretic peptides and their relation to cardiovascular structure and function in a population-based sample of subjects aged 70 years
    Kai M Eggers
    Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala, Sweden
    Am J Cardiol 103:1032-8. 2009
    ....
  43. doi request reprint High-sensitive cardiac troponin T outperforms novel diagnostic biomarkers in patients with acute chest pain
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden
    Clin Chim Acta 413:1135-40. 2012
    ..However, the information obtained from hs-cTnT levels might be improved when combined with results of other biomarkers of myocardial injury...
  44. ncbi request reprint Usefulness of plasma N-terminal proatrial natriuretic peptide (proANP) as an early predictor of outcome in unstable angina pectoris or non-ST-elevation acute myocardial infarction
    Tomas Jernberg
    Department of Cardiology, Cardiothoracic Center, University Hospital, Uppsala, Sweden
    Am J Cardiol 89:64-6. 2002
  45. ncbi request reprint Low molecular weight heparin (dalteparin) compared to unfractionated heparin as an adjunct to rt-PA (alteplase) for improvement of coronary artery patency in acute myocardial infarction-the ASSENT Plus study
    Lars Wallentin
    Department of Medical Sciences, Cardiology, University Hospital, S 751 85, Uppsala, Sweden
    Eur Heart J 24:897-908. 2003
    ..We compared the effects of low molecular weight heparin (LMWH) versus unfractionated heparin (UFH) as an adjunct to recombinant tissue-plasminogen activator (alteplase) on coronary artery patency and clinical outcomes in AMI...
  46. ncbi request reprint Diagnostic value of serial measurement of cardiac markers in patients with chest pain: limited value of adding myoglobin to troponin I for exclusion of myocardial infarction
    Kai Marten Eggers
    Department of Cardiology, Cardiothoracic Center, University Hospital, Uppsala, Sweden
    Am Heart J 148:574-81. 2004
    ..Despite improved laboratory assays for cardiac markers and a revised standard for definition of myocardial infarction (AMI), early detection of coronary ischemia in unselected patients with chest pain remains a difficult challenge...
  47. doi request reprint Cardiac troponin assay classification by both clinical and analytical performance characteristics: a study on outcome prediction
    Per Venge
    Department of Medical Sciences, Clinical Chemistry, University of Uppsala, Uppsala, Sweden
    Clin Chem 59:976-81. 2013
    ..We compared four widely used "clinically usable" cardiac troponin I (cTnI) assays with an assay designated "not acceptable" for accuracy in predicting the clinical outcome of death...
  48. ncbi request reprint Improved adherence to Swedish national guidelines for acute myocardial infarction: the Quality Improvement in Coronary Care (QUICC) study
    Rickard Carlhed
    Uppsala Clinical Research Center, University Hospital, Uppsala, Sweden
    Am Heart J 152:1175-81. 2006
    ..The intervention used a national web-based quality registry to generate local and regular real-time performance feedback...
  49. doi request reprint Autoantibodies to cardiac troponin in acute coronary syndromes
    Bertil Lindahl
    Department of Medical Sciences and Uppsala Clinical Research Center, University of Uppsala, Sweden
    Clin Chim Acta 411:1793-8. 2010
    ..However, the prognostic importance of the occurrence of cTnaAb is unknown...
  50. ncbi request reprint Influence on coagulation activity by subcutaneous LMW heparin as an adjuvant treatment to fibrinolysis in acute myocardial infarction
    Gunnar Frostfeldt
    Department of Medical Science, Cardiology, University Hospital, Uppsala, Sweden
    Thromb Res 105:193-9. 2002
    ..This might be of importance as remaining high coagulation activity is associated with signs of early reocclusion and raised mortality...
  51. ncbi request reprint Artificial neural network algorithms for early diagnosis of acute myocardial infarction and prediction of infarct size in chest pain patients
    Kai M Eggers
    Department of Medical Sciences, Cardiology, University Hospital Uppsala, S 751 85 Uppsala, Sweden
    Int J Cardiol 114:366-74. 2007
    ..To prospectively validate artificial neural network (ANN)-algorithms for early diagnosis of myocardial infarction (AMI) and prediction of 'major infarct' size in patients with chest pain and without ECG changes diagnostic for AMI...
  52. ncbi request reprint [Prognosis in unstable coronary artery disease. Multimarker strategy is the best basis for the therapeutic choice]
    Stefan James
    Kardiologiska kliniken, Akademiska sjukhuset, Uppsala
    Lakartidningen 101:1514-9, 1521-2. 2004
    ....
  53. ncbi request reprint Risk prediction in chest pain patients by biochemical markers including estimates of renal function
    Kai M Eggers
    Department of Medical Sciences, Cardiology, University Hospital Uppsala, S 751 85 Uppsala, Sweden
    Int J Cardiol 128:207-13. 2008
    ..Early risk stratification of patients with chest pain may be improved by combining cardiac Troponin I (cTnI) results and ECG findings with markers of left-ventricular dysfunction, inflammation or renal function...
  54. ncbi request reprint Development of myocardial microcirculation and metabolism in acute ST-elevation myocardial infarction evaluated with positron emission tomography
    Gunnar Frostfeldt
    Cardiology, Department of Medical Sciences, Uppsala University Hospital, Sweden
    J Nucl Cardiol 12:43-54. 2005
    ..Early reperfusion is an established therapeutic objective in acute myocardial infarction (MI). The relationship of regional myocardial microcirculation and metabolism toward outcome in acute human MI is not well known...
  55. doi request reprint Clinical performance of two highly sensitive cardiac troponin I assays
    Per Venge
    Department of Medical Sciences, Clinical Chemistry, University of Uppsala
    Clin Chem 55:109-16. 2009
    ..The aim of this study was to compare the clinical performance of 2 sensitive cTnI assays with 10% CV imprecision below the 99th percentile upper reference limit...
  56. ncbi request reprint Pre-hospital thrombolysis delivered by paramedics is associated with reduced time delay and mortality in ambulance-transported real-life patients with ST-elevation myocardial infarction
    Erik Bjorklund
    Department of Cardiology, University Hospital of Uppsala, 751 85 Uppsala Sweden
    Eur Heart J 27:1146-52. 2006
    ..We therefore evaluated treatment delays and outcome in a large cohort of ambulance-transported real-life patients with ST-elevation myocardial infarction (STEMI) according to PHT delivered by paramedics or in-hospital thrombolysis...
  57. ncbi request reprint Persistent cardiac troponin I elevation in stabilized patients after an episode of acute coronary syndrome predicts long-term mortality
    Kai M Eggers
    Department of Medical Sciences, Cardiology, University Hospital Uppsala, S 751 85 Uppsala, Sweden
    Circulation 116:1907-14. 2007
    ..However, the prevalence and prognostic importance of persistent troponin elevation in stabilized patients after an episode of non-ST-elevation acute coronary syndrome are unknown and were therefore assessed in this study...
  58. ncbi request reprint Clinical performance of three cardiac troponin assays in patients with unstable coronary artery disease (a FRISC II substudy)
    Per Venge
    Department of Clinical Chemistry, University of Uppsala, Uppsala, Sweden
    Am J Cardiol 89:1035-41. 2002
    ..It is also apparent that assays with superior sensitivity, such as the Access AccuTnI, identify more patients with poor prognosis who are candidates for early invasive procedures...
  59. ncbi request reprint Visualisation and quantification of peri-operative myocardial infarction after coronary artery bypass surgery with contrast-enhanced magnetic resonance imaging
    Johnny Steuer
    Department of Cardiothoracic Surgery, University Hospital, SE 751 85 Uppsala, Sweden
    Eur Heart J 25:1293-9. 2004
    ..To evaluate if elevated biochemical marker levels after coronary artery bypass grafting (CABG) correspond to the amount of peri-operatively infarcted myocardium, quantified by magnetic resonance imaging (MRI) post-operatively...
  60. doi request reprint Knowledge and attitudes toward seeking medical care for AMI-symptoms
    Catrin Henriksson
    Uppsala Clinical Research Center, Uppsala University, Sweden
    Int J Cardiol 147:224-7. 2011
    ..Time is crucial when an acute myocardial infarction (AMI) occurs, but patients often wait before seeking medical care...
  61. ncbi request reprint NT-ProBNP in non-ST-elevation acute coronary syndrome
    Tomas Jernberg
    Department of Medical Sciences and Cardiology and the Uppsala Clinical Research Center, Sweden
    J Card Fail 11:S54-8. 2005
    ..The role of N-terminal pro-brain natriuretic peptide (NT-proBNP) in the early treatment of patients with non-ST-elevation acute coronary syndrome (NSTACS) has been evaluated in 6 large studies that include >12,000 patients...
  62. ncbi request reprint Troponin and C-reactive protein have different relations to subsequent mortality and myocardial infarction after acute coronary syndrome: a GUSTO-IV substudy
    Stefan K James
    Department of Medical Sciences Cardiology, Thoraxcenter, Academic Hospital, 751 85 Uppsala, Sweden
    J Am Coll Cardiol 41:916-24. 2003
    ..We sought to evaluate C-reactive protein (CRP) and troponin T (TnT) as predictors of risk of the individual end points of mortality and myocardial infarction (MI) in a large cohort of patients with acute coronary syndrome (ACS)...
  63. ncbi request reprint Prognostic value of ST-segment resolution-when and what to measure
    Per Johanson
    Clinical Experimental Research Laboratory, Sahlgrenska University Hospital Ostra, SE 41685 Goteborg, Sweden
    Eur Heart J 24:337-45. 2003
    ..We now set out to compare the prognostic value of previously suggested cut-offs for ST-segment resolution, and determine the times to measure these...
  64. ncbi request reprint Consideration of the total ST-segment deviation on the initial electrocardiogram for predicting final acute posterior myocardial infarct size in patients with maximum ST-segment deviation as depression in leads V1 through V3. A FRISC II substudy
    Rasmus S Ripa
    Division of Cardiology, Duke University Medical Center, Durham, NC 27705, USA
    J Electrocardiol 38:180-6. 2005
    ..Documentation of a relationship between the quantities of acute ST change and final QRS estimated acute myocardial infarction (AMI) size could form the basis for clinical trials to determine the value of reperfusion therapy...
  65. ncbi request reprint QT dispersion measured by an automatic continuous method early in patients admitted for chest pain
    Milos Kesek
    Department of Cardiology, Akademiska Hospital, 751 85 Uppsala, Sweden
    Int J Cardiol 85:217-24; discussion 225-7. 2002
    ..A problem with the manual measurement of QTd is operator dependency. This can be avoided by using an automatic method. We investigated QTd, derived from multiple automatic measurements, as a risk marker in a population with chest pain...
  66. ncbi request reprint Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction
    Ronnier J Aviles
    Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, OH 44951, USA
    N Engl J Med 346:2047-52. 2002
    ..However, there is concern that renal dysfunction may impair the prognostic value, because cardiac troponin T may be cleared by the kidney...
  67. ncbi request reprint [BNP or NT-proBNP should be analyzed in suspected heart failure. Guidelines for analysis and interpretation]
    Tomas Jernberg
    Hjartkliniken, Karolinska Universitetssjukhuset, Stockholm
    Lakartidningen 103:1289-92, 1295. 2006
  68. ncbi request reprint Soluble CD40L levels are regulated by the -3459 A>G polymorphism and predict myocardial infarction and the efficacy of antithrombotic treatment in non-ST elevation acute coronary syndrome
    Anders Malarstig
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, S 751 85 Uppsala, Sweden
    Arterioscler Thromb Vasc Biol 26:1667-73. 2006
    ..The aim was to investigate the prognostic importance of soluble (s) CD40L levels, single nucleotide polymorphisms (SNP) in the CD40LG gene, and the relation between sCD40L and SNPs in patients with acute coronary syndromes (ACS)...
  69. ncbi request reprint Symptoms and type of symptom onset in acute coronary syndrome in relation to ST elevation, sex, age, and a history of diabetes
    Marie Thuresson
    Division of Cardiology, Orebro University Hospital, SE 701 85 Orebro, Sweden
    Am Heart J 150:234-42. 2005
    ..The aim of this study was therefore to explore the characteristics and severity of symptoms among patients with an ACS in overall terms and in relation to the type of ACS, sex, age, and diabetes...
  70. ncbi request reprint Improving guideline adherence through intensive quality improvement and the use of a National Quality Register in Sweden for acute myocardial infarction
    Anette Peterson
    County Council of Jönköping, Sweden
    Qual Manag Health Care 16:25-37. 2007
    ..The project engaged 25% of the Swedish hospitals...
  71. ncbi request reprint Growth-differentiation factor-15 improves risk stratification in ST-segment elevation myocardial infarction
    Tibor Kempf
    Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Heart J 28:2858-65. 2007
    ..We explored the prognostic utility of GDF-15 in patients with ST-segment elevation myocardial infarction (STEMI) receiving fibrinolytic therapy...
  72. ncbi request reprint The relation of QT dispersion and localized QT difference to coronary pathology in a population with unstable coronary artery disease
    Milos Kesek
    Department of Cardiology, Norrland University Hospital, 90185 Umea, Sweden
    Ann Noninvasive Electrocardiol 8:22-9. 2003
    ..In order to elucidate a possible local mechanism, we investigated the relation between QT dispersion, an ECG parameter reflecting the local dispersion, and angiographical measures in a population with unstable coronary artery disease...
  73. doi request reprint Factors that influence the use of ambulance in acute coronary syndrome
    Marie Thuresson
    Division of Cardiology, Orebro University Hospital, School of Health and Medical Sciences, Orebro, Sweden
    Am Heart J 156:170-6. 2008
    ..In spite of this, only 50% to 60% of persons with myocardial infarction initiate care by using the emergency medical service. The aim of this study was to define factors influencing the use of ambulance in ACS...
  74. ncbi request reprint Natriuretic peptides in unstable coronary artery disease
    Tomas Jernberg
    Department of Medical Sciences, Cardiology and Uppsala Research Center, Sweden
    Eur Heart J 25:1486-93. 2004
    ..Before a routine use of BNP or NT-proBNP in unstable CAD can be recommended, the cost-effectiveness of adding these new markers to the currently routine markers and their impact on selection of treatment needs further evaluation...
  75. ncbi request reprint Growth differentiation factor 15 for risk stratification and selection of an invasive treatment strategy in non ST-elevation acute coronary syndrome
    Kai C Wollert
    Department of Cardiology and Angiology, Hannover University Medical School, Hannover, Germany
    Circulation 116:1540-8. 2007
    ..We hypothesized that the circulating level of growth differentiation factor 15 (GDF-15) may improve risk stratification...
  76. ncbi request reprint Principal component analysis of the T wave in patients with chest pain and conduction disturbances
    Milos Kesek
    Department of Cardiology, Norrland University Hospital, Umea, Sweden
    Pacing Clin Electrophysiol 27:1378-87. 2004
    ..The nondipolar PCA component contained a moderate amount of prognostic information not present in a simple ECG diagnosis of a conduction disturbance...
  77. ncbi request reprint Prognostic value of growth-differentiation factor-15 in patients with non-ST-elevation acute coronary syndrome
    Kai C Wollert
    Department of Cardiology and Angiology, Hannover Medical School, Germany
    Circulation 115:962-71. 2007
    ..Circulating levels of GDF-15 may provide prognostic information in patients with non-ST-elevation acute coronary syndrome...
  78. ncbi request reprint ST-segment analyses and residual thrombi in the infarct-related artery: a report from the ASSENT PLUS ST-monitoring substudy
    Per Johanson
    Department of Medicine Cardiology, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Am Heart J 147:853-8. 2004
    ..We have recently suggested that ST variability during the reperfusion-phase is of prognostic importance. We wanted to further investigate this and relate it to angiographic findings...
  79. ncbi request reprint Diabetes mellitus: the major risk factor in unstable coronary artery disease even after consideration of the extent of coronary artery disease and benefits of revascularization
    Anna Norhammar
    Department of Cardiology, Karolinska Hospital, Stockholm, Sweden
    J Am Coll Cardiol 43:585-91. 2004
    ..This study was designed to study the influence of diabetes on the outcome of unstable coronary artery disease (CAD)...
  80. ncbi request reprint Quantitative analysis of the admission electrocardiogram identifies patients with unstable coronary artery disease who benefit the most from early invasive treatment
    Lene Holmvang
    The Heart Center 2141, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    J Am Coll Cardiol 41:905-15. 2003
    ..The present study is a sub-study of the previously published Fast Revascularization during InStability in Coronary artery disease trial (FRISC-II)...
  81. doi request reprint Prevalence and pathophysiological mechanisms of elevated cardiac troponin I levels in a population-based sample of elderly subjects
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Eur Heart J 29:2252-8. 2008
    ....
  82. ncbi request reprint ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology
    Carina Blomstrom-Lundqvist
    Circulation 108:1871-909. 2003