L Lind

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. pmc Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study
    Duk Hee Lee
    Department of Preventative Medicine, Kyungpook National University, Daegu, Korea
    Diabetes Care 34:1778-84. 2011
  2. doi request reprint Genetic variation in the dimethylarginine dimethylaminohydrolase 1 gene (DDAH1) is related to asymmetric dimethylarginine (ADMA) levels, but not to endothelium-dependent vasodilation
    Lars Lind
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Vasc Med 18:192-9. 2013
  3. pmc Association of biomarkers of inflammation and cell adhesion with lung function in the elderly: a population-based study
    Antje Kuhlmann
    Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Uppsala University Hospital, 751 85, Uppsala, Sweden
    BMC Geriatr 13:82. 2013
  4. doi request reprint Relationships between three different tests to evaluate endothelium-dependent vasodilation and cardiovascular risk in a middle-aged sample
    Lars Lind
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Hypertens 31:1570-4. 2013
  5. doi request reprint Variation in genes in the endothelin pathway and endothelium-dependent and endothelium-independent vasodilation in an elderly population
    L Lind
    Department of Medical Sciences, Uppsala University, Stockholm, Sweden
    Acta Physiol (Oxf) 208:88-94. 2013
  6. doi request reprint A combined test of acetylcholine-mediated vasodilation of both the forearm resistance vessels and the radial artery
    Lars Lind
    Department of Medical Sciences, University Hospital, Uppsala University, Uppsala, Sweden
    Clin Physiol Funct Imaging 33:206-10. 2013
  7. doi request reprint The echogenicity of the intima-media complex in the common carotid artery is related to insulin resistance measured by the hyperinsulinemic clamp in elderly men
    Lars Lind
    Department of Medicine, Uppsala University, Uppsala, Sweden
    Clin Physiol Funct Imaging 33:137-42. 2013
  8. doi request reprint EpiHealth: a large population-based cohort study for investigation of gene-lifestyle interactions in the pathogenesis of common diseases
    Lars Lind
    Department of Medical Sciences, Uppsala University, 751 85, Uppsala, Sweden
    Eur J Epidemiol 28:189-97. 2013
  9. pmc Endotoxin-induced and vaccine-induced systemic inflammation both impair endothelium-dependent vasodilation, but not pulse wave reflection
    Lars Lind
    Department of Medicine, University Hospital, Uppsala, Sweden
    Vasc Health Risk Manag 8:447-53. 2012
  10. pmc Serum concentrations of phthalate metabolites are related to abdominal fat distribution two years later in elderly women
    P Monica Lind
    Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden
    Environ Health 11:21. 2012

Collaborators

Detail Information

Publications156 found, 100 shown here

  1. pmc Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study
    Duk Hee Lee
    Department of Preventative Medicine, Kyungpook National University, Daegu, Korea
    Diabetes Care 34:1778-84. 2011
    ..However, evidence from prospective studies is sparse. This study was performed to evaluate prospective associations of type 2 diabetes with selected POPs among the elderly...
  2. doi request reprint Genetic variation in the dimethylarginine dimethylaminohydrolase 1 gene (DDAH1) is related to asymmetric dimethylarginine (ADMA) levels, but not to endothelium-dependent vasodilation
    Lars Lind
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Vasc Med 18:192-9. 2013
    ..We investigated if genetic variation in the DDAH1 and DDAH2 genes were related to ADMA and l-arginine levels, as well as measures of endothelium-dependent vasodilation...
  3. pmc Association of biomarkers of inflammation and cell adhesion with lung function in the elderly: a population-based study
    Antje Kuhlmann
    Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Uppsala University Hospital, 751 85, Uppsala, Sweden
    BMC Geriatr 13:82. 2013
    ..The aim of the study was to analyse associations of biomarkers and combinations of biomarkers with lung function in an elderly general population...
  4. doi request reprint Relationships between three different tests to evaluate endothelium-dependent vasodilation and cardiovascular risk in a middle-aged sample
    Lars Lind
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Hypertens 31:1570-4. 2013
    ..During recent years a third technique, peripheral artery tonometry (PAT) using EndoPat, has been introduced. We now aimed to investigate the relationships between these techniques, and their relation to cardiovascular risk...
  5. doi request reprint Variation in genes in the endothelin pathway and endothelium-dependent and endothelium-independent vasodilation in an elderly population
    L Lind
    Department of Medical Sciences, Uppsala University, Stockholm, Sweden
    Acta Physiol (Oxf) 208:88-94. 2013
    ..This study aimed to investigate whether circulating levels of endotehlin-1 or genetic variations in genes in the endothelin pathway were related to endothelium-dependent vasodilation...
  6. doi request reprint A combined test of acetylcholine-mediated vasodilation of both the forearm resistance vessels and the radial artery
    Lars Lind
    Department of Medical Sciences, University Hospital, Uppsala University, Uppsala, Sweden
    Clin Physiol Funct Imaging 33:206-10. 2013
    ..To evaluate a new combined test of endothelium-dependent vasodilation (EDV) in the forearm resistance vessel and the radial artery...
  7. doi request reprint The echogenicity of the intima-media complex in the common carotid artery is related to insulin resistance measured by the hyperinsulinemic clamp in elderly men
    Lars Lind
    Department of Medicine, Uppsala University, Uppsala, Sweden
    Clin Physiol Funct Imaging 33:137-42. 2013
    ....
  8. doi request reprint EpiHealth: a large population-based cohort study for investigation of gene-lifestyle interactions in the pathogenesis of common diseases
    Lars Lind
    Department of Medical Sciences, Uppsala University, 751 85, Uppsala, Sweden
    Eur J Epidemiol 28:189-97. 2013
    ..Third, the sample is followed for occurrence of outcomes using nationwide medical registers. This overview presents the study design and some baseline characteristics from the first year of data collection in the EpiHealth study...
  9. pmc Endotoxin-induced and vaccine-induced systemic inflammation both impair endothelium-dependent vasodilation, but not pulse wave reflection
    Lars Lind
    Department of Medicine, University Hospital, Uppsala, Sweden
    Vasc Health Risk Manag 8:447-53. 2012
    ..However, the vascular effects of these two mechanisms of inducing inflammation have not been compared in the same individuals...
  10. pmc Serum concentrations of phthalate metabolites are related to abdominal fat distribution two years later in elderly women
    P Monica Lind
    Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden
    Environ Health 11:21. 2012
    ..Data from both dual-energy X-ray absorptiometry (DXA) and abdominal magnetic resonance imaging (MRI) were used...
  11. doi request reprint Can persistent organic pollutants and plastic-associated chemicals cause cardiovascular disease?
    L Lind
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Intern Med 271:537-53. 2012
    ..Nevertheless, taken together, current evidence suggests that further longitudinal and experimental studies should be conducted to investigate the effect of exposure to both POPs and PACs, such as bisphenol A and phthalates...
  12. pmc A systematic review of triage-related interventions to improve patient flow in emergency departments
    Sven Oredsson
    Department of Emergency Medicine, Helsingborg Hospital, Helsingborg, Sweden
    Scand J Trauma Resusc Emerg Med 19:43. 2011
    ..Overcrowding in emergency departments is a worldwide problem. A systematic literature review was undertaken to scientifically explore which interventions improve patient flow in emergency departments...
  13. pmc Emergency department triage scales and their components: a systematic review of the scientific evidence
    Nasim Farrohknia
    The Swedish Council for Health Technology Assessment and Dep of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Scand J Trauma Resusc Emerg Med 19:42. 2011
    ....
  14. pmc Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal femur in elderly men and women: a cohort study
    Helena Hallström
    Research and Development Department, Toxicology Division, National Food Administration, Box 622, SE 751 26 Uppsala, Sweden
    Nutr Metab (Lond) 7:12. 2010
    ....
  15. pmc Left ventricular geometric patterns and adaptations to hemodynamics are similar in elderly men and women
    Said Masiha
    Department of Cardiology, Uppsala University Hospital, Uppsala, Sweden
    BMC Cardiovasc Disord 11:25. 2011
    ..However, differences between the genders in the relationship of hemodynamics to LV geometry are not well known.The present study aims to investigate differences between the genders in this respect, in a sample of elderly persons...
  16. pmc Single nucleotide polymorphisms in the apolipoprotein B and low density lipoprotein receptor genes affect response to antihypertensive treatment
    Ulrika Liljedahl
    Department of Medical Sciences, Uppsala University, Uppsala University Hospital, Entrance 70, 3rd Floor, 751 85 Uppsala, Sweden
    BMC Cardiovasc Disord 4:16. 2004
    ..Dyslipidemia has been associated with hypertension. The present study explored if polymorphisms in genes encoding proteins in lipid metabolism could be used as predictors for the individual response to antihypertensive treatment...
  17. pmc T wave abnormalities, high body mass index, current smoking and high lipoprotein (a) levels predict the development of major abnormal Q/QS patterns 20 years later. A population-based study
    Christina Strom Moller
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Sweden
    BMC Cardiovasc Disord 6:10. 2006
    ..Our aim was to identify factors that could predict the development of ECG markers of CHD, such as abnormal Q/QS patterns, ST segment depression and T wave abnormalities, in 70-year-old men, irrespective of clinical outcome...
  18. pmc Adipocyte-derived leucine aminopeptidase genotype and response to antihypertensive therapy
    Par Hallberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    BMC Cardiovasc Disord 3:11. 2003
    ..The enzyme seems to be particularly abundant in the heart. Recently, the Arg528-encoding allele of the ALAP gene was shown to be associated with essential hypertension...
  19. ncbi request reprint Left ventricular mass is related to endothelium-dependent vasodilation in the forearm, but not in the brachial artery, in elderly subjects: the Prospective Investigation of the Vasculature in Uppsala Seniors study
    L Lind
    Department of Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden
    J Hum Hypertens 22:767-73. 2008
    ....
  20. ncbi request reprint The stroke volume/pulse pressure ratio predicts coronary heart disease mortality in a population of elderly men
    Lars Lind
    Department of Medical Sciences, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    J Hypertens 22:899-905. 2004
    ..The relations to cardiovascular risk factors and its predictive capacity in the general population are not known...
  21. ncbi request reprint Ageing impairs insulin-mediated vasodilatation but not forearm glucose uptake
    L Lind
    Department of Internal Medicine, University Hospital, S 751 85 Uppsala, Sweden
    Eur J Clin Invest 31:860-4. 2001
    ..It is unclear if insulin-mediated vasodilatation is altered by ageing and if this affects insulin-mediated glucose uptake...
  22. ncbi request reprint Circulating markers of inflammation and atherosclerosis
    Lars Lind
    Department of Medical Sciences, University Hospital, S 751 85, Uppsala, Sweden
    Atherosclerosis 169:203-14. 2003
    ....
  23. ncbi request reprint The effects of mental stress and the cold pressure test on flow-mediated vasodilation
    Lars Lind
    Department of Medicine, University Hospital, Uppsala, Sweden
    Blood Press 11:22-7. 2002
    ..However, when FMD was normalized for the degree of hyperaemic blood flow, the driver of the vasodilation in the brachial artery, a reduction in flow-mediated vasodilation was seen during both mental and cold pressure stress...
  24. ncbi request reprint Evaluation of four different methods to measure endothelium-dependent vasodilation in the human peripheral circulation
    Lars Lind
    Department of Internal Medicine, University Hospital, SE 751 85 Uppsala, Sweden
    Clin Sci (Lond) 102:561-7. 2002
    ....
  25. ncbi request reprint The effect of smoking on endothelial vasodilatory function evaluated by local infusion of metacholine in the forearm is dependent on the duration of smoking
    Lars Lind
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    Nicotine Tob Res 5:125-30. 2003
    ....
  26. ncbi request reprint Atherosclerosis measured by whole body magnetic resonance angiography and carotid artery ultrasound is related to arterial compliance, but not to endothelium-dependent vasodilation - the Prospective Investigation of the Vasculature in Uppsala Seniors (PIV
    Lars Lind
    Departments of Medicine, Uppsala University Hospital, Uppsala 751 85, Sweden
    Clin Physiol Funct Imaging 29:321-9. 2009
    ....
  27. ncbi request reprint The types of circulating fatty acids influence vascular reactivity
    Lars Lind
    Departments of Internal Medicine, University Hospital, Uppsala, Sweden
    Lipids 37:1141-5. 2002
    ..05). Both the cross-sectional and intervention data support the view that the composition of serum FA, which at least partly reflects the quality of dietary fat, plays a role in determinations of vascular reactivity...
  28. ncbi request reprint Analysis of endothelium-dependent vasodilation by use of the radial artery pulse wave obtained by applanation tonometry
    Lars Lind
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Clin Physiol Funct Imaging 23:50-7. 2003
    ....
  29. doi request reprint Arterial stiffness, but not endothelium-dependent vasodilation, is related to a low Ankle-Brachial index. The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS)
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Uppsala, Sweden
    Clin Physiol Funct Imaging 31:182-7. 2011
    ....
  30. ncbi request reprint Impact of ageing on the measurement of endothelium-dependent vasodilation
    L Lind
    Department of Medicine, Uppsala University Hospital, Akademiska sjukhuset, 751 85 Uppsala, Sweden
    Pharmacol Rep 58:41-6. 2006
    ..The usefulness of other methods used in population studies, such as pulse wave analysis using a beta-2 receptor agonist as vasodilator and the hyperaemic blood flow velocity have to be further validated...
  31. doi request reprint Endothelium-dependent vasodilation in relation to different measurements of blood pressure in the elderly: the prospective investigation of the vasculature in Uppsala Seniors study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Uppsala, Sweden
    Blood Press Monit 13:245-50. 2008
    ..Here, we investigated whether these relationships were more powerful if blood pressure was measured invasively or by transformation to central aortic blood pressure...
  32. ncbi request reprint Heart rate recovery after exercise is related to the insulin resistance syndrome and heart rate variability in elderly men
    Lars Lind
    Department of Medicine, University Hospital, Uppsala, Sweden
    Am Heart J 144:666-72. 2002
    ..We investigated the associations between heart rate recovery after exercise (as a suggested measure of vagal activity), heart rate variability, and measurements of the insulin resistance syndrome...
  33. ncbi request reprint A comparison of three different methods to evaluate endothelium-dependent vasodilation in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Molndal, Sweden
    Arterioscler Thromb Vasc Biol 25:2368-75. 2005
    ..This study aimed to evaluate the feasibility and usefulness of these techniques in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study...
  34. doi request reprint Arterial compliance and endothelium-dependent vasodilation are independently related to coronary risk in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Uppsala, Sweden
    Clin Physiol Funct Imaging 28:373-7. 2008
    ..In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, we studied the interplay between arterial compliance and endothelium-dependent vasodilation on coronary risk...
  35. ncbi request reprint Lipids and endothelium-dependent vasodilation--a review
    Lars Lind
    Department of Medicine, Uppsala University Hospital and AstraZeneca R and D, Möndal, Sweden
    Lipids 37:1-15. 2002
    ..Furthermore, discrepancies regarding the role of triglycerides and fat content in food may be explained by divergent effects of different fatty acids on the endothelium...
  36. ncbi request reprint The echogenecity of the intima-media complex in the common carotid artery is closely related to the echogenecity in plaques
    Lars Lind
    Department of Medicine, Uppsala University Hospital, 751 85 Uppsala, Sweden
    Atherosclerosis 195:411-4. 2007
    ..The aim of the present study is to relate the grey scale median of the intima-media complex (IM-GSM) of the common carotid artery (CCA) to the echogenecity of carotid plaques...
  37. ncbi request reprint The impairment in endothelial function induced by non-esterified fatty acids can be reversed by insulin
    L Lind
    Department of Internal Medicine, University Hospital of Uppsala, Sweden
    Clin Sci (Lond) 99:169-74. 2000
    ..In conclusion, an acute increase in serum levels of non-esterified fatty acids increased lipid oxidation and decreased EDV. The effect on EDV of non-esterified fatty acids could be reversed by hyperinsulinaemia...
  38. doi request reprint Endothelial function in resistance and conduit arteries and 5-year risk of cardiovascular disease
    Lars Lind
    Department of Medical Sciences, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Circulation 123:1545-51. 2011
    ..Little is known of the relations of measures of endothelial function in resistance and conduit arteries to incident cardiovascular disease in the general population, and available techniques have not been compared...
  39. ncbi request reprint Arterial compliance influences the measurement of flow-mediated vasodilation, but not acetylcholine-mediated forearm blood flow. The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital and AstraZeneca R and D Mölndal, 751 85 Uppsala, Sweden
    Atherosclerosis 190:212-5. 2007
    ..Using data from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, we investigated if a reduced arterial distensibility could influence FMD measurements...
  40. ncbi request reprint Vasodilation in resistance arteries is related to the apolipoprotein B/A1 ratio in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, AstraZeneca R and D Molndal, 751 85 Uppsala, Sweden
    Atherosclerosis 190:378-84. 2007
    ..The present study aims to relate apoB/A1 to endothelium-dependent vasodilation, an early marker of atherosclerosis, in the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study...
  41. ncbi request reprint Endothelium-dependent vasodilation, insulin resistance and the metabolic syndrome in an elderly cohort: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, 751 85 Uppsala, Sweden
    Atherosclerosis 196:795-802. 2008
    ..In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, different techniques to assess vasodilation in conduit and resistance arteries were evaluated in relation to the MetS and insulin resistance...
  42. ncbi request reprint Systolic and diastolic hypertension impair endothelial vasodilatory function in different types of vessels in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Uppsala and AstraZeneca R and D, Molndal, Sweden
    J Hypertens 24:1319-27. 2006
    ..Endothelium-dependent vasodilation (EDV) is known to be impaired in middle-aged hypertensive individuals, but less is known regarding hypertension in the elderly...
  43. ncbi request reprint C-reactive protein and e-selectin levels are related to vasodilation in resistance, but not conductance arteries in the elderly: the prospective investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, 751 85 Uppsala, Sweden
    Atherosclerosis 199:129-37. 2008
    ..The aim of the present study is to relate a wide range of inflammatory markers to vasoreactivity in both resistance and conductance arteries...
  44. ncbi request reprint Evaluation of endothelium-dependent vasodilation in humans
    L Lind
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    Blood Press 10:124-30. 2001
    ..Furthermore, six less established methods for the evaluation of EDV in different vascular beds in humans are presented...
  45. ncbi request reprint Vasodilation and visceral fat in elderly subjects: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Uppsala, Sweden
    Atherosclerosis 194:e64-71. 2007
    ..In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, we related VAT and other obesity indices to endothelium-dependent vasodilation in both capacitance and resistance arteries...
  46. ncbi request reprint Brachial artery intima-media thickness and echogenicity in relation to lipids and markers of oxidative stress in elderly subjects:--the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) Study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Uppsala, Sweden
    Lipids 43:133-41. 2008
    ..Thus, both thickness and echogenicity of the brachial artery intima-media complex might be useful biomarkers in the future...
  47. ncbi request reprint A comparison of three different methods to determine arterial compliance in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Sweden
    J Hypertens 24:1075-82. 2006
    ..This study aimed to evaluate the feasibility and relation to cardiac risk of three of these techniques in the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study...
  48. ncbi request reprint Dyslipidemia and an unfavorable fatty acid profile predict left ventricular hypertrophy 20 years later
    J Sundstrom
    Departments of Public Health and Caring Sciences J S, B V, H O L and Medical Sciences L L, B A, Uppsala University, Sweden, and Department of Nutrition A A, KTL National Public Health Institute, Helsinki, Finland
    Circulation 103:836-41. 2001
    ....
  49. ncbi request reprint Left ventricular concentric remodeling rather than left ventricular hypertrophy is related to the insulin resistance syndrome in elderly men
    J Sundstrom
    Department of Public Health, Uppsala University, Sweden
    Circulation 101:2595-600. 2000
    ..The purpose of this study was to elucidate these associations through the use of a large sample of elderly men...
  50. ncbi request reprint Single nucleotide polymorphisms predict the change in left ventricular mass in response to antihypertensive treatment
    Ulrika Liljedahl
    Department of Medical Sciences, Uppsala University, Sweden
    J Hypertens 22:2321-8. 2004
    ....
  51. ncbi request reprint Both cyclooxygenase- and cytokine-mediated inflammation are associated with carotid intima-media thickness
    M Wohlin
    Department of Public Health and Caring Sciences Geriatrics and Clinical Nutrition, Faculty of Medicine, Uppsala University, Uppsala Science Park, SE 751 85 Uppsala, Sweden
    Cytokine 38:130-6. 2007
    ..It is unknown if various modes of inflammation (cyclooxygenase [COX]-mediated, cytokine-mediated), oxidative stress and anti-oxidants are independently related to CCA-IMT...
  52. ncbi request reprint Serum aldosterone changes during hyperinsulinemia are correlated to body mass index and insulin sensitivity in patients with essential hypertension
    A Haenni
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Sweden
    J Hypertens 19:107-12. 2001
    ..To measure the effects of hyperinsulinemia on serum electrolyte status and associated hormones, and on serum free fatty acid (FFA) concentrations, in patients with essential hypertension...
  53. ncbi request reprint Divergent effects of different beta-blocking agents on endothelium-dependent vasodilatation in the human forearm
    B von Zur Mühlen
    Department of Internal Medicine, University Hospital of Uppsala, Sweden
    Blood Press 9:287-92. 2000
    ..The aim of this study was to evaluate the direct effect of three principally different beta-receptor blocking agents on endothelium-dependent vasodilatation (EDV) in the human forearm...
  54. ncbi request reprint Endothelium-dependent vasodilation in the uvea of hypertensive and normotensive rats
    E Granstam
    Department of Ophthalmology, University Hospital of Uppsala, Sweden
    Curr Eye Res 17:189-96. 1998
    ....
  55. ncbi request reprint Several factors associated with the insulin resistance syndrome are predictors of left ventricular systolic dysfunction in a male population after 20 years of follow-up
    J Arnlov
    Departments of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Am Heart J 142:720-4. 2001
    ..The epidemiologic data on heart failure are scarce. This study aimed at identifying predictors of left ventricular systolic dysfunction in a cohort of middle-aged men with a 20-year follow-up...
  56. ncbi request reprint Beta1-adrenergic receptor gene polymorphisms and response to beta1-adrenergic receptor blockade in patients with essential hypertension
    J Karlsson
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Clin Cardiol 27:347-50. 2004
    ..Both have been associated with altered receptor activity in vitro, and with hypertension and cardiac failure in vivo...
  57. ncbi request reprint Gender-specific association between preproendothelin-1 genotype and reduction of systolic blood pressure during antihypertensive treatment--results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA)
    P Hallberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Clin Cardiol 27:287-90. 2004
    ..No study has yet determined the effect of this polymorphism on the change in blood pressure during antihypertensive treatment...
  58. ncbi request reprint Treatment with irbesartan or atenolol improves endothelial function in essential hypertension
    B von Zur Mühlen
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    J Hypertens 19:1813-8. 2001
    ....
  59. ncbi request reprint Endothelium-dependent vasodilation is related to the fatty acid composition of serum lipids in healthy subjects
    M Sarabi
    Department of Internal Medicine, University Hospital of Uppsala, S751 85, Uppsala, Sweden
    Atherosclerosis 156:349-55. 2001
    ..It is concluded that the FA composition of serum lipids, partly reflecting the composition of dietary fat and previously associated with the development of CVD, was associated with endothelial function in apparently healthy subjects...
  60. ncbi request reprint An ordinary mixed meal transiently impairs endothelium-dependent vasodilation in healthy subjects
    M Sarabi
    Department of Internal Medicine, University Hospital of Uppsala, Uppsala, Sweden
    Acta Physiol Scand 172:107-13. 2001
    ..In conclusion, an ordinary mixed meal transiently attenuated endothelium-dependent vasodilation. Free fatty acids may be involved in this effect on endothelial function...
  61. ncbi request reprint Apolipoprotein E epsilon4 genotype is independently associated with increased intima-media thickness in a recessive pattern
    M Wohlin
    Department of Public Health and Caring Sciences Geriatrics and Clinical Nutrition, Faculty of Medicine, Uppsala University, Uppsala Science Park, 751 85, Uppsala, Sweden
    Lipids 42:451-6. 2007
    ....
  62. ncbi request reprint Blood flow is an important determinant of forearm glucose uptake following a mixed meal
    A Fugmann
    Departments of Internal Medicine, University Hospital of Uppsala, S 751 85, Uppsala, Sweden
    Acta Diabetol 40:113-7. 2003
    ..These results support the view that modulation of limb blood flow is a determinant of glucose uptake...
  63. ncbi request reprint Ankle brachial index <0.9 underestimates the prevalence of peripheral artery occlusive disease assessed with whole-body magnetic resonance angiography in the elderly
    J Wikstrom
    Department of Radiology and Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Radiol 49:143-9. 2008
    ..Whole-body magnetic resonance angiography (WBMRA) permits noninvasive vascular assessment, which can be utilized in epidemiological studies...
  64. ncbi request reprint Impaired insulin sensitivity is an independent predictor of common carotid intima-media thickness in a population sample of elderly men
    M Wohlin
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Atherosclerosis 170:181-5. 2003
    ..In conclusion, this study is the first to establish impaired insulin sensitivity, measured by the euglycemic hyperinsulinemic clamp test, as an independent predictor of CCA-IMT in a population-based sample of elderly men...
  65. ncbi request reprint A single nucleotide polymorphism in the promoter region of the osteoprotegerin gene is related to intima-media thickness of the carotid artery in hypertensive patients. The Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA
    H Brändström
    Department of Medical Sciences, Uppsala University, Sweden
    Blood Press 13:152-7. 2004
    ..The present study confirms our previous finding and shows that polymorphism in the promoter region of OPG is associated with vascular morphology in hypertensive subjects...
  66. ncbi request reprint The blood pressure response to antihypertensive treatment with lisinopril or bendrofluazide is related to the calcium and magnesium contents in skeletal muscle
    A Haenni
    Department of Geriatrics, Uppsala, Sweden
    Am J Hypertens 9:273-6. 1996
    ..05), especially in the patients treated with lisinopril. Thus, an association between the calcium and magnesium balance in skeletal muscle and the blood pressure response to antihypertensive treatment was found in the present study...
  67. ncbi request reprint An echolucent carotid artery intima-media complex is a new and independent predictor of mortality in an elderly male cohort
    M Wohlin
    Department of Public Health and Caring Sciences, Uppsala University, Sweden
    Atherosclerosis 205:486-91. 2009
    ..We investigated the prognostic value of intima-media (IM) echogenicity (measured as the grey scale median [GSM]) for mortality compared with intima-media thickness (IMT) in a population-based sample of elderly men...
  68. ncbi request reprint Insulin-mediated vasodilation and glucose uptake are independently related to fasting serum nonesterified fatty acids in elderly men
    P Andersson
    Department of Geriatrics, Uppsala University, Uppsala, Sweden
    J Intern Med 246:529-37. 1999
    ..To investigate candidate predictors for insulin sensitivity in healthy elderly males, with special reference to the influence of insulin-mediated skeletal muscle blood flow and serum nonesterified fatty acids (NEFA)...
  69. ncbi request reprint Vitamin D is related to blood pressure and other cardiovascular risk factors in middle-aged men
    L Lind
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    Am J Hypertens 8:894-901. 1995
    ..35, P < .05), insulin sensitivity during clamp (r = 0.54, P < .001), and lipoprotein lipase activity both in adiposal tissue (r = 0.48, P < .005) and skeletal muscle (r = 0.38, P < .03).(ABSTRACT TRUNCATED AT 250 WORDS)..
  70. ncbi request reprint Magnesium infusion improves endothelium-dependent vasodilation in the human forearm
    Arvo Haenni
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Sweden
    Am J Hypertens 15:10-5. 2002
    ..In conclusion, this in vivo study showed that intraarterial magnesium infusion increased EDV in the infused human forearm, which is in accordance with findings in previous in vitro and animal experiments...
  71. ncbi request reprint Polymorphisms in the renin-angiotensin system and endothelium-dependent vasodilation in normotensive subjects
    L Kurland
    Department of Medical Sciences, Uppsala University Hospital, Sweden
    Clin Physiol 21:343-9. 2001
    ..This together with the observation that the AC AT1R genotype is associated with a reduction in both EDV and EIDV, supports the hypothesis that endothelial vasodilatory function is influenced by genes in the renin-angiotensinogen system...
  72. ncbi request reprint Twenty-four hour ambulatory blood pressure in a population of elderly men
    K Björklund
    Department of Public Health and Caring Sciences Section of Geriatrics, University of Uppsala, Uppsala, Sweden
    J Intern Med 248:501-10. 2000
    ..The principal aim was to study ambulatory and office blood pressure in a population of elderly men. We also wanted to describe the prevalence of hypertension and investigate the blood pressure control in treated elderly hypertensives...
  73. ncbi request reprint Improved hemorheological properties during infusion of a lipid emulsion (Intralipid) in healthy subjects
    T Linde
    Department of Medical Sciences and Geriatrics, University Hospital, Uppsala, Sweden
    Intensive Care Med 26:1462-5. 2000
    ..We have recently shown that hyperinsulinemia exerts a negative effect on erythrocyte deformability, and here the effect of hyperinsulinemia combined with Intralipid was studied...
  74. ncbi request reprint Echocardiographic and electrocardiographic diagnoses of left ventricular hypertrophy predict mortality independently of each other in a population of elderly men
    J Sundstrom
    Departments of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Circulation 103:2346-51. 2001
    ....
  75. ncbi request reprint Insulin resistance, dietary fat intake and blood pressure predict left ventricular diastolic function 20 years later
    Johan Arnlov
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Nutr Metab Cardiovasc Dis 15:242-9. 2005
    ....
  76. doi request reprint B-type natriuretic peptides and their relation to cardiovascular structure and function in a population-based sample of subjects aged 70 years
    Kai M Eggers
    Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala, Sweden
    Am J Cardiol 103:1032-8. 2009
    ....
  77. ncbi request reprint A new Q/QS pattern on the resting electrocardiogram is associated with impaired insulin secretion and a poor prognosis in elderly men independently of history of myocardial infarction
    K Dunder
    Department of Public Health and Caring Sciences Geriatrics Medical Sciences, Uppsala University, Akademiska sjukhuset, Uppsala, Sweden
    J Intern Med 255:221-8. 2004
    ..To evaluate risk factors and prognosis of subjects who had developed a new Q/QS pattern on the resting electrocardiogram (ECG) in relation to history of myocardial infarction (MI)...
  78. ncbi request reprint Endothelium-dependent vasodilatation in forearm is impaired in stroke patients
    A Stenborg
    Department of Medical Sciences, Uppsala University, Sweden
    J Intern Med 259:569-75. 2006
    ..To investigate endothelium-dependent vasodilatation (EDV) in stroke patients...
  79. ncbi request reprint Myocardial insulin-mediated glucose uptake and left ventricular geometry
    J Sundstrom
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University Hospital, Uppsala, Sweden
    Blood Press 10:27-32. 2001
    ....
  80. ncbi request reprint Systolic blood pressure alterations during hyperinsulinemia are related to changes in ionized calcium status
    A Haenni
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Sweden
    Am J Hypertens 14:1106-11. 2001
    ..The objective of this study was to evaluate associations between alterations in ion status and BP changes during euglycemic hyperinsulinemia in healthy normotensive subjects...
  81. ncbi request reprint Reduction of blood pressure during long-term treatment with active vitamin D (alphacalcidol) is dependent on plasma renin activity and calcium status. A double-blind, placebo-controlled study
    L Lind
    Department of Internal Medicine, , Uppsala, Sweden
    Am J Hypertens 2:20-5. 1989
    ....
  82. doi request reprint Kidney function and discrimination of cardiovascular risk in middle-aged men
    I Soveri
    Department of Medical Sciences, Uppsala University, Sweden
    J Intern Med 266:406-13. 2009
    ..To define the optimal glomerular filtration rate (GFR) cut off for discriminating the risk of myocardial infarction or cardiovascular death...
  83. ncbi request reprint The alterations in insulin sensitivity during angiotensin converting enzyme inhibitor treatment are related to changes in the calcium/magnesium balance
    A Haenni
    Department of Geriatrics, Uppsala University, Sweden
    Am J Hypertens 10:145-51. 1997
    ..We conclude that the changes in the studied metabolic variables and serum ACE activity during ACE inhibitor treatment are related to alterations in mineral status and the balance between calcium and magnesium concentrations in serum...
  84. ncbi request reprint The Doppler-derived myocardial performance index is determined by both left ventricular systolic and diastolic function as well as by afterload and left ventricular mass
    Lars Lind
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Echocardiography 22:211-6. 2005
    ....
  85. ncbi request reprint Endothelium-dependent vasodilation in normotensive subjects with a familial history of essential hypertension and in young subjects with borderline hypertension
    Jonas Millgård
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Blood Press 11:279-84. 2002
    ..To investigate if young normotensive subjects with a familial history of essential hypertension (FHH) or young borderline-hypertensive (BHT) subjects have a defect endothelial function...
  86. ncbi request reprint Impaired endothelial function of forearm resistance arteries in CADASIL patients
    Anna Stenborg
    Department of Medical Sciences, University and University Hospital of Uppsala, Sweden
    Stroke 38:2692-7. 2007
    ..Mice expressing the mutated protein display early dysfunction in vasoreactivity in resistance arteries, but studies of patients have been inconclusive so far...
  87. ncbi request reprint Effects of nitric oxide synthase inhibition and endothelin ETA receptor blockade on haemodynamics in hypertensive rats
    S O Granstam
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    Clin Exp Pharmacol Physiol 25:693-701. 1998
    ..Furthermore, NOS inhibition, but not ETA blockade, blunted the expected ACh-induced vasodilation in the heart and kidney in WKY rats, but not in skeletal muscle in both strains...
  88. ncbi request reprint Metabolic cardiovascular risk factors and sodium sensitivity in hypertensive subjects
    L Lind
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    Am J Hypertens 5:502-5. 1992
    ..A putative mechanism might be an increased activity in pressor systems also affecting glucose and lipid metabolism...
  89. ncbi request reprint Impaired endothelium-dependent vasodilatation in renal failure in humans
    M Annuk
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Nephrol Dial Transplant 16:302-6. 2001
    ..29, P<0.005) in the CRF group. CONCLUSIONS: Patients with moderate CRF have an impaired EDV even after correction for traditional cardiovascular risk factors and this impairment is related to the degree of renal failure...
  90. ncbi request reprint Polymorphisms in the estrogen receptor alpha gene and endothelial function in resistance and conduit arteries in the elderly
    Erik Ingelsson
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, SE 751 85 Uppsala, Sweden
    Atherosclerosis 199:162-71. 2008
    ..Our aim was to examine the relations of single nucleotide polymorphisms (SNPs) in the estrogen receptor alpha gene (ESR1) to endothelium-dependent vasodilation...
  91. doi request reprint Hyperaemic blood-flow velocities in systole and diastole relate to coronary risk in divergent ways
    Susann J Järhult
    Department of Medicine, Uppsala University Hospital, Sweden
    Clin Physiol Funct Imaging 28:189-95. 2008
    ..The present study aimed to investigate the relative importance of hyperaemic systolic and diastolic blood-flow velocity in the forearm regarding both FMD and cardiovascular risk factors...
  92. ncbi request reprint Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population
    Majd A I Mirza
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Atherosclerosis 207:546-51. 2009
    ..Additional longitudinal studies that evaluate the predictive power of FGF23 and whether FGF23 has additional clinical applications are needed...
  93. ncbi request reprint The apolipoprotein B/AI ratio and the metabolic syndrome independently predict risk for myocardial infarction in middle-aged men
    Lars Lind
    Department of Medical Sciences, Uppsala University, Sweden
    Arterioscler Thromb Vasc Biol 26:406-10. 2006
    ....
  94. ncbi request reprint Impact of follow-up time and re-measurement of the electrocardiogram and conventional cardiovascular risk factors on their predictive value for myocardial infarction
    Christina Strom Moller
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    J Intern Med 260:22-30. 2006
    ....
  95. ncbi request reprint Relationships between serum fatty acid composition and multiple markers of inflammation and endothelial function in an elderly population
    Helena Petersson
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, 75185 Uppsala, Sweden
    Atherosclerosis 203:298-303. 2009
    ..This study investigates the associations between serum FA composition, including SCD-1 index, and various inflammatory and endothelial function markers...
  96. ncbi request reprint A microarray minisequencing system for pharmacogenetic profiling of antihypertensive drug response
    Ulrika Liljedahl
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Pharmacogenetics 13:7-17. 2003
    ..Our results highlight the potential of microarray-based technology for SNP genotyping in pharmacogenetics...
  97. doi request reprint The effects of antihypertensive treatment on the doppler-derived myocardial performance index in patients with hypertensive left ventricular hypertrophy: results from the Swedish irbesartan in left ventricular hypertrophy investigation versus atenolol (SI
    Stefan Liljedahl
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    Echocardiography 26:753-8. 2009
    ..To investigate the effects of antihypertensive treatment on the Doppler-derived myocardial performance index (MPI) in patients with hypertensive left ventricular hypertrophy...
  98. ncbi request reprint Mental stress impairs endothelial vasodilatory function by a beta-adrenergic mechanism
    M Eriksson
    Department of Anaesthesiology and Intensive Care, Uppsala University Hospital, Uppsala, Sweden
    Endothelium 14:151-6. 2007
    ..05). Thus, impairment of endothelial vasodilatory function induced by mental stress could be blocked by beta-adrenergic, but not alpha-adrenergic, receptor blockade...
  99. ncbi request reprint Factor analysis of fatty acids in serum lipids as a measure of dietary fat quality in relation to the metabolic syndrome in men
    Eva Warensjo
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Am J Clin Nutr 84:442-8. 2006
    ..A specific fatty acid (FA) composition in plasma lipid esters is related to the metabolic syndrome (MetS) and may influence the development of the MetS...
  100. ncbi request reprint Endothelium-dependent vasodilation is impaired in apparently healthy subjects with a family history of myocardial infarction
    Lars Lind
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    J Cardiovasc Risk 9:53-7. 2002
    ..To investigate whether endothelial-dependent vasodilation is altered in healthy subjects with a family history of myocardial infarction...
  101. ncbi request reprint A single nucleotide polymorphism in the promoter region of the human gene for osteoprotegerin is related to vascular morphology and function
    Helena Brändström
    Department of Medical Sciences, Uppsala University, SE 751 85 Uppsala, Sweden
    Biochem Biophys Res Commun 293:13-7. 2002
    ..01) as compared to those with the T allele. Thus, our results show that the polymorphism in the promoter region of OPG is associated with both vascular morphology and function in apparently healthy subjects...