Sune Larsson

..It is reasonable to believe that we have so far only seen the beginning when it comes to clinical applications...

..The purpose of this article is to review the possible use of augmentation as a technique in the treatment of fractures in the extremities as well as in the spine...

..This article describes the current literature related to internal fixation or primary replacement in periarticular fractures around the hip and knee...

..Apart from augmentation of the cancellous bone and development of new load-sharing devices, endoprosthetic replacement with specially designed fracture prosthesis has become more frequent...

..Clinical studies now are needed to determine the indications in which bone augmentation with bone-graft substitutes (BGSs) would merit clinical usage...

..Injectable bone substitutes, and especially CS, have also been targeted as potentially good carriers for antibiotics and growth factors...

..There is little evidence to support immediate weight bearing after uncemented total hip arthroplasty (THA)...

..Periprosthetic BMD was measured in the 7 Gruen zones with DXA and the stability of the femoral stem was assessed by radiostereometric analysis (RSA) after surgery and at 3, 12, 24, and 60 months...

..OAH often leads to a fixed external rotation of the hip, leading to difficulties in positioning during DXA measurements. We compared BMD in OAH-affected legs and healthy legs...

..The main purpose of this study was to compare the fixation of cemented keeled glenoid components with that of cemented in-line pegged glenoid components...

..Our conclusion is that a GSK-3 inhibitor drug may prove effective as an anabolic strategy in the treatment of diseases characterized by low bone mass, since AZD2858 has extensive bone building effects at predominantly trabecular sites...

..1 mm for the uncemented stems. We concluded at 2 years these stems provided similar fixation in rheumatoid shoulders. Level of Evidence: Therapeutic Level I. See the Guidelines for Authors for a complete description of levels of evidence...

..The fractures healed with a bony callus without an obvious endochondral component, suggesting that AZD2858 drives mesenchymal cells into the osteoblastic pathway. This leads to direct bone repair in an unstable fracture milieu...

..The aim of this study was to determine quality of life (QoL) changes over time after internal fixation of acetabular fractures...

..There was a strong correlation between the average subsidence at 3 and 24 months (r = 0.96). Early full weight bearing and active rehabilitation can be used for the uncemented CLS stem without increased risk of early loosening...

..Nonoperative treatment is preferred for clavicular fractures irrespective of fracture and patient characteristics. However, recent studies indicate that long term results are not as favourable as previously considered...

..Five years after total hip arthroplasty there was a decrease in bone mineral content and bone mineral density, but no changes in lean mass or fat mass...

..Data from previous studies are inconsistent, and it is therefore uncertain whether, to what extent, and at what level leisure physical activity influences the risk of osteoporotic fractures in men...

..The degree of early weightbearing did not affect the migration pattern...

..0008, ANOVA with Tukey's multiple comparison test). We hypothesize that the higher bone density induced by nanoHAP might be due to nanocrystals of calcium phosphate acting as direct building blocks for biomineralization...

..We report a patient who had a graft taken from the proximal tibia and had a displaced fracture 2 weeks later after a fall. Five similar cases have been reported previously, of which none has required surgical intervention...

..However, in vivo these interactions could be broken by enzymatic activity, creating a macroporous structure that allows easier cell infiltration, thus, facilitating bone formation...

..There is no consensus as to which is best treatment of femoral fractures in children...

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..To evaluate unilateral external fixation when applied as the standard treatment of children with displaced femoral shaft fractures...

..To construct a questionnaire to assess outcomes in patients who underwent internal fixation for acetabular fractures...

..Together these novel findings suggest that a rapid primary effect of excess retinol on bone tissue is the impairment of endosteal/marrow blood flow leading to hypoxia and pathological endosteal mineralization...

..Patients with predictive risk factors, such as fractures with no bony contact or displacement, especially if comminuted, and also elderly patients with fractures should be considered for more active treatment options...

..The present study was performed to investigate a potential role of IL-4 and IL-13 in fracture healing and bone induction by demineralized xenogenic bone matrix (DXBM)...

..It is suggested that human exposure to low levels of multiple EDCs may have implications for bone structure and human health...

..Concern has been expressed about the large number of radiolucent lines around the ulnar component of the Kudo elbow prosthesis in medium-term follow-up...

..The purpose of this study was to investigate patient-reported outcome following surgical treatment of pelvic fractures using quality of life instruments...

..We report the identification of four QTLs for femoral traits: one for bone strength, one for endosteal circumference, and two affecting mineral density of noncortical bone...

..The radiopaque pCPC may be considered to be used for minimal invasive treatment of vertebral fractures since it has good handling, radiopacity and allows healing of cancellous bone in parallel with the resorption of the cement...

..The aim with this study was to evaluate whether augmentation with resorbable calcium-phosphate cement could improve fracture stability during the early period after surgery as shown in biomechanical studies...

..Compared with previous studies of patients with similar fractures treated with casts and restricted weight-bearing, the loss in bone mineral density was less and not as longstanding...

..The aim with this study was to measure whether augmentation with resorbable calcium-phosphate cement could improve fracture stability as shown in biomechanical studies...

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..In ten shoulders rotation exceeded 2 degrees in one or more axes with retroversion/anteversion being most common. No correlation was found between migration and the presence of radiolucencies on conventional radiographs...

..0002). Our findings showed that all screws with radiolucent zones had low extraction torques or low pull-out resistance. A radiolucent zone is a good indicator of loosening of a pedicle screw...

..001). There were more radiolucent zones surrounding the uncoated screws than the HA-coated screws (p < 0.001). HA coating of pedicle screws resulted in improved fixation with reduced risk of loosening of the screws...

..Hence, a wide array of behavioural and developmental traits were genetically linked to FP...

..The effectiveness of partial weightbearing after hip surgery has been questioned as well as the need of intensive physiotherapy...

..The RSA method may serve as a scientific tool to accurately evaluate the significance of supporting novel biomaterials for the early stability and the rate of healing in fractures...