Sune Larsson

Summary

Affiliation: Uppsala University Hospital
Country: Sweden

Publications

  1. doi request reprint Calcium phosphates: what is the evidence?
    Sune Larsson
    Department of Orthopaedic Surgery, Uppsala University, Uppsala, Sweden
    J Orthop Trauma 24:S41-5. 2010
  2. ncbi request reprint Cement augmentation in fracture treatment
    S Larsson
    Department of Orthopedics, Uppsala University Hospital, Uppsala, Sweden
    Scand J Surg 95:111-8. 2006
  3. doi request reprint Periarticular fractures around the hip and knee: fix or replace?
    Sune Larsson
    Department of Orthopedics, Uppsala University, Uppsala, Sweden
    J Orthop Trauma 25:S90-4. 2011
  4. doi request reprint Optimising implant anchorage (augmentation) during fixation of osteoporotic fractures: is there a role for bone-graft substitutes?
    Sune Larsson
    Department of Orthopedics, Uppsala University, Uppsala S 751 85, Sweden
    Injury 42:S72-6. 2011
  5. doi request reprint Injectable bone-graft substitutes: current products, their characteristics and indications, and new developments
    Sune Larsson
    Department of Orthopedics, Uppsala University, SE 751 85 Uppsala, Sweden
    Injury 42:S30-4. 2011
  6. ncbi request reprint Treatment of osteoporotic fractures
    S Larsson
    Department of Orthopedics, Uppsala University Hospital, Sweden
    Scand J Surg 91:140-6. 2002
  7. doi request reprint Rats treated with AZD2858, a GSK3 inhibitor, heal fractures rapidly without endochondral bone formation
    Gregor Sisask
    Department of Surgical Sciences, Uppsala University, SE 751 85 Uppsala, Sweden
    Bone 54:126-32. 2013
  8. doi request reprint Osteogenic potential of Sr-doped calcium phosphate hollow spheres in vitro and in vivo
    Gry Hulsart-Billström
    Department of Orthopedics, Uppsala University, Uppsala, Sweden
    J Biomed Mater Res A 101:2322-31. 2013
  9. pmc The effects of different weight-bearing regimes on press-fit cup stability: a randomised study with five years of follow-up using radiostereometry
    Olof Wolf
    Surgical Sciences, Orthopaedic, Uppsala, Sweden
    Int Orthop 36:735-40. 2012
  10. pmc Differences in hip bone mineral density may explain the hip fracture pattern in osteoarthritic hips
    Olof Wolf
    Department of Orthopedics, Uppsala University Hospital, Sweden
    Acta Orthop 80:308-13. 2009

Collaborators

Detail Information

Publications47

  1. doi request reprint Calcium phosphates: what is the evidence?
    Sune Larsson
    Department of Orthopaedic Surgery, Uppsala University, Uppsala, Sweden
    J Orthop Trauma 24:S41-5. 2010
    ..It is reasonable to believe that we have so far only seen the beginning when it comes to clinical applications...
  2. ncbi request reprint Cement augmentation in fracture treatment
    S Larsson
    Department of Orthopedics, Uppsala University Hospital, Uppsala, Sweden
    Scand J Surg 95:111-8. 2006
    ..The purpose of this article is to review the possible use of augmentation as a technique in the treatment of fractures in the extremities as well as in the spine...
  3. doi request reprint Periarticular fractures around the hip and knee: fix or replace?
    Sune Larsson
    Department of Orthopedics, Uppsala University, Uppsala, Sweden
    J Orthop Trauma 25:S90-4. 2011
    ..This article describes the current literature related to internal fixation or primary replacement in periarticular fractures around the hip and knee...
  4. doi request reprint Optimising implant anchorage (augmentation) during fixation of osteoporotic fractures: is there a role for bone-graft substitutes?
    Sune Larsson
    Department of Orthopedics, Uppsala University, Uppsala S 751 85, Sweden
    Injury 42:S72-6. 2011
    ..Clinical studies now are needed to determine the indications in which bone augmentation with bone-graft substitutes (BGSs) would merit clinical usage...
  5. doi request reprint Injectable bone-graft substitutes: current products, their characteristics and indications, and new developments
    Sune Larsson
    Department of Orthopedics, Uppsala University, SE 751 85 Uppsala, Sweden
    Injury 42:S30-4. 2011
    ..Injectable bone substitutes, and especially CS, have also been targeted as potentially good carriers for antibiotics and growth factors...
  6. ncbi request reprint Treatment of osteoporotic fractures
    S Larsson
    Department of Orthopedics, Uppsala University Hospital, Sweden
    Scand J Surg 91:140-6. 2002
    ..Apart from augmentation of the cancellous bone and development of new load-sharing devices, endoprosthetic replacement with specially designed fracture prosthesis has become more frequent...
  7. doi request reprint Rats treated with AZD2858, a GSK3 inhibitor, heal fractures rapidly without endochondral bone formation
    Gregor Sisask
    Department of Surgical Sciences, Uppsala University, SE 751 85 Uppsala, Sweden
    Bone 54:126-32. 2013
    ..The fractures healed with a bony callus without an obvious endochondral component, suggesting that AZD2858 drives mesenchymal cells into the osteoblastic pathway. This leads to direct bone repair in an unstable fracture milieu...
  8. doi request reprint Osteogenic potential of Sr-doped calcium phosphate hollow spheres in vitro and in vivo
    Gry Hulsart-Billström
    Department of Orthopedics, Uppsala University, Uppsala, Sweden
    J Biomed Mater Res A 101:2322-31. 2013
    ..SrCPS implantation induced bone formation and resulted in complete resorption and defect consolidation...
  9. pmc The effects of different weight-bearing regimes on press-fit cup stability: a randomised study with five years of follow-up using radiostereometry
    Olof Wolf
    Surgical Sciences, Orthopaedic, Uppsala, Sweden
    Int Orthop 36:735-40. 2012
    ..There is little evidence to support immediate weight bearing after uncemented total hip arthroplasty (THA)...
  10. pmc Differences in hip bone mineral density may explain the hip fracture pattern in osteoarthritic hips
    Olof Wolf
    Department of Orthopedics, Uppsala University Hospital, Sweden
    Acta Orthop 80:308-13. 2009
    ..OAH often leads to a fixed external rotation of the hip, leading to difficulties in positioning during DXA measurements. We compared BMD in OAH-affected legs and healthy legs...
  11. pmc Periprosthetic bone mineral density and fixation of the uncemented CLS stem related to different weight bearing regimes: A randomized study using DXA and RSA in 38 patients followed for 5 years
    Olof Wolf
    Department of Orthopedics, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 81:286-91. 2010
    ..Periprosthetic BMD was measured in the 7 Gruen zones with DXA and the stability of the femoral stem was assessed by radiostereometric analysis (RSA) after surgery and at 3, 12, 24, and 60 months...
  12. doi request reprint Morphological differences in BMP-2-induced ectopic bone between solid and crushed hyaluronan hydrogel templates
    Gry Hulsart-Billström
    Department of Orthopedics, Uppsala University, Uppsala, Sweden
    J Mater Sci Mater Med 24:1201-9. 2013
    ..However, in vivo these interactions could be broken by enzymatic activity, creating a macroporous structure that allows easier cell infiltration, thus, facilitating bone formation...
  13. doi request reprint Stability of cemented in-line pegged glenoid compared with keeled glenoid components in total shoulder arthroplasty
    Hans Rahme
    Department of Orthopedics, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    J Bone Joint Surg Am 91:1965-72. 2009
    ..The main purpose of this study was to compare the fixation of cemented keeled glenoid components with that of cemented in-line pegged glenoid components...
  14. doi request reprint Effects of postoperative weight-bearing on body composition and bone mineral density after uncemented total hip arthroplasty
    Olof Wolf
    Dept of Orthopedics, Uppsala University Hospital, Uppsala, Sweden
    J Rehabil Med 45:498-503. 2013
    ....
  15. doi request reprint GSK-3 inhibition by an orally active small molecule increases bone mass in rats
    Richard Marsell
    Department of Surgical Sciences, Uppsala University, SE 751 85 Uppsala, Sweden
    Bone 50:619-27. 2012
    ..Our conclusion is that a GSK-3 inhibitor drug may prove effective as an anabolic strategy in the treatment of diseases characterized by low bone mass, since AZD2858 has extensive bone building effects at predominantly trabecular sites...
  16. ncbi request reprint Cement and press-fit humeral stem fixation provides similar results in rheumatoid patients
    Hans Rahme
    Department of Orthopedics, Uppsala University Hospital, Sweden
    Clin Orthop Relat Res 448:28-32. 2006
    ..1 mm for the uncemented stems. We concluded at 2 years these stems provided similar fixation in rheumatoid shoulders. Level of Evidence: Therapeutic Level I. See the Guidelines for Authors for a complete description of levels of evidence...
  17. doi request reprint Quality of life after operative fixation of displaced acetabular fractures
    Tomas Borg
    Department of Orthopaedic Surgery, Uppsala University, Uppsala, Sweden
    J Orthop Trauma 26:445-50. 2012
    ..The aim of this study was to determine quality of life (QoL) changes over time after internal fixation of acetabular fractures...
  18. ncbi request reprint The effect of early weight bearing on migration pattern of the uncemented CLS stem in total hip arthroplasty
    Håkan Ström
    Department of Orthopaedics, University of Uppsala, Uppsala, Sweden
    J Arthroplasty 22:1122-9. 2007
    ..There was a strong correlation between the average subsidence at 3 and 24 months (r = 0.96). Early full weight bearing and active rehabilitation can be used for the uncemented CLS stem without increased risk of early loosening...
  19. ncbi request reprint Sequelae from clavicular fractures are common: a prospective study of 222 patients
    Jan Nowak
    Department of Orthopedics, Uppsala University Hospital, Sweden
    Acta Orthop 76:496-502. 2005
    ..Nonoperative treatment is preferred for clavicular fractures irrespective of fracture and patient characteristics. However, recent studies indicate that long term results are not as favourable as previously considered...
  20. ncbi request reprint Early migration pattern of the uncemented CLS stem in total hip arthroplasties
    Håkan Ström
    Department of Orthopaedics, University of Uppsala, Uppsala, Sweden
    Clin Orthop Relat Res 454:127-32. 2007
    ..The degree of early weightbearing did not affect the migration pattern...
  21. pmc Leisure physical activity and the risk of fracture in men
    Karl Michaelsson
    Section of Orthopaedics, Department of Surgical Sciences, University Hospital, Uppsala, Sweden
    PLoS Med 4:e199. 2007
    ..Data from previous studies are inconsistent, and it is therefore uncertain whether, to what extent, and at what level leisure physical activity influences the risk of osteoporotic fractures in men...
  22. doi request reprint Calcium phosphates compounds in conjunction with hydrogel as carrier for BMP-2: a study on ectopic bone formation in rats
    Gry Hulsart-Billström
    Uppsala University, Department of Orthopaedics, SE 751 85 Uppsala, Sweden
    Acta Biomater 7:3042-9. 2011
    ..0008, ANOVA with Tukey's multiple comparison test). We hypothesize that the higher bone density induced by nanoHAP might be due to nanocrystals of calcium phosphate acting as direct building blocks for biomineralization...
  23. ncbi request reprint Fracture of the tibia: complication of bone grafting to the anterior maxilla
    Andreas Thor
    Department of Surgical Sciences, Oral and Maxillofacial Surgery, Uppsala University Hospital, Uppsala, Sweden
    Br J Oral Maxillofac Surg 44:46-8. 2006
    ..We report a patient who had a graft taken from the proximal tibia and had a displaced fracture 2 weeks later after a fall. Five similar cases have been reported previously, of which none has required surgical intervention...
  24. doi request reprint Bone formation in interleukin-4 and interleukin-13 depleted mice
    Carl Johan Silfverswärd
    Department of Surgical Sciences, University of Uppsala, Uppsala, Sweden
    Acta Orthop 79:410-20. 2008
    ..The present study was performed to investigate a potential role of IL-4 and IL-13 in fracture healing and bone induction by demineralized xenogenic bone matrix (DXBM)...
  25. doi request reprint Bisphosphonate-linked hyaluronic acid hydrogel sequesters and enzymatically releases active bone morphogenetic protein-2 for induction of osteogenic differentiation
    Gry Hulsart-Billström
    Department of Surgical Sciences, Orthopedics, Uppsala University Hospital, Uppsala SE 751 85, Sweden
    Biomacromolecules 14:3055-63. 2013
    ..Altogether, the present findings indicate that covalent grafting of HA hydrogel with BP groups can alter the clinical effects of BMPs in bone tissue regeneration. ..
  26. ncbi request reprint A cost analysis of three methods of treating femoral shaft fractures in children: a comparison of traction in hospital, traction in hospital/home and external fixation
    Hanne Hedin
    Department of Orthopedics, Falun Hospital, Falun, Sweden
    Acta Orthop Scand 75:241-8. 2004
    ..There is no consensus as to which is best treatment of femoral fractures in children...
  27. ncbi request reprint External fixation of displaced femoral shaft fractures in children: a consecutive study of 98 fractures
    Hanne Hedin
    Department of Orthopaedic Surgery, Falun Hospital, Sweden
    J Orthop Trauma 17:250-6. 2003
    ..To evaluate unilateral external fixation when applied as the standard treatment of children with displaced femoral shaft fractures...
  28. ncbi request reprint The effect of augmentation with resorbable or conventional bone cement on the holding strength for femoral neck fracture devices
    Fredrik Eriksson
    Department of Orthopedics, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    J Orthop Trauma 16:302-10. 2002
    ..To compare maximum extraction torque and pull-out load for femoral neck fracture implants inserted with standard technique or after augmentation with polymethylmethacrylate (PMMA) or calcium phosphate cement (Norian SRS)...
  29. ncbi request reprint Questionnaire to assess treatment outcomes of acetabular fractures
    Tomas Borg
    Department of Orthopaedic Surgery, Uppsala University, Uppsala, Sweden
    J Orthop Surg (Hong Kong) 20:55-60. 2012
    ..To construct a questionnaire to assess outcomes in patients who underwent internal fixation for acetabular fractures...
  30. doi request reprint High dietary intake of retinol leads to bone marrow hypoxia and diaphyseal endosteal mineralization in rats
    Thomas Lind
    Department of Medical Sciences, Section of Clinical Pharmacology, University Hospital, Uppsala, Sweden
    Bone 48:496-506. 2011
    ..Together these novel findings suggest that a rapid primary effect of excess retinol on bone tissue is the impairment of endosteal/marrow blood flow leading to hypoxia and pathological endosteal mineralization...
  31. ncbi request reprint Can we predict long-term sequelae after fractures of the clavicle based on initial findings? A prospective study with nine to ten years of follow-up
    Jan Nowak
    Shoulder Service, Department of Orthopaedics, Uppsala University Hospital, Uppsala, Sweden
    J Shoulder Elbow Surg 13:479-86. 2004
    ..Patients with predictive risk factors, such as fractures with no bony contact or displacement, especially if comminuted, and also elderly patients with fractures should be considered for more active treatment options...
  32. doi request reprint Application of scaffolds for bone regeneration strategies: current trends and future directions
    Gry Hulsart Billström
    Department of Orthopedics, Uppsala University, Uppsala, Sweden
    Injury 44:S28-33. 2013
    ..Here we examine both the basic science behind the development of scaffolds and comprehensively and systematically review the clinical applications...
  33. ncbi request reprint Quantitative trait loci for BMD and bone strength in an intercross between domestic and wildtype chickens
    Carl Johan Rubin
    Department of Medical Sciences, Uppsala University, and Department of Internal Medicine, The Sahlgrenska University Hospital, Goteborg, Sweden
    J Bone Miner Res 22:375-84. 2007
    ..We report the identification of four QTLs for femoral traits: one for bone strength, one for endosteal circumference, and two affecting mineral density of noncortical bone...
  34. pmc In vivo evaluation of an injectable premixed radiopaque calcium phosphate cement
    Jonas Aberg
    Division of Applied Materials Science, Department of Engineering Sciences, Uppsala University, 75237 Uppsala, Sweden
    Int J Biomater 2011:232574. 2011
    ..The radiopaque pCPC may be considered to be used for minimal invasive treatment of vertebral fractures since it has good handling, radiopacity and allows healing of cancellous bone in parallel with the resorption of the cement...
  35. doi request reprint Health-related quality of life and life satisfaction in patients following surgically treated pelvic ring fractures. A prospective observational study with two years follow-up
    Tomas Borg
    Department of Orthopaedic Surgery, Uppsala University Hospital, Uppsala, Sweden
    Injury 41:400-4. 2010
    ..The purpose of this study was to investigate patient-reported outcome following surgical treatment of pelvic fractures using quality of life instruments...
  36. ncbi request reprint Stable fixation of the ulnar component in the Kudo elbow prosthesis. A radiostereometric (RSA) study of 13 prostheses with 2-year follow-up
    Hans Rahme
    Department of Orthopedics, University Hospital, SE 751 85 Uppsala, Sweden
    Acta Orthop 76:104-8. 2005
    ..Concern has been expressed about the large number of radiolucent lines around the ulnar component of the Kudo elbow prosthesis in medium-term follow-up...
  37. doi request reprint Pregnant ewes exposed to multiple endocrine disrupting pollutants through sewage sludge-fertilized pasture show an anti-estrogenic effect in their trabecular bone
    P Monica Lind
    Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Ulleråkersvägen 40, 751 85 Uppsala, Sweden
    Sci Total Environ 408:2340-6. 2010
    ..It is suggested that human exposure to low levels of multiple EDCs may have implications for bone structure and human health...
  38. ncbi request reprint Stability of internally fixed femoral neck fractures augmented with resorbable cement. A prospective randomized study using radiostereometry
    P Mattsson
    Department of Orthopedics, Uppsala University Hospital, Uppsala, Sweden
    Scand J Surg 92:215-9. 2003
    ..The aim with this study was to evaluate whether augmentation with resorbable calcium-phosphate cement could improve fracture stability during the early period after surgery as shown in biomechanical studies...
  39. ncbi request reprint Limited bone loss in the hip and heel after reamed intramedullary fixation and early weight-bearing of tibial fractures
    A Emami
    Department of Orthopaedic Surgery, Uppsala University Hospital, Uppsala, Sweden
    J Orthop Trauma 15:560-5. 2001
    ..Compared with previous studies of patients with similar fractures treated with casts and restricted weight-bearing, the loss in bone mineral density was less and not as longstanding...
  40. ncbi request reprint Unstable trochanteric fractures augmented with calcium phosphate cement. A prospective randomized study using radiostereometry to measure fracture stability
    P Mattsson
    Department of Orthopedics, Uppsala University Hospital, Uppsala, Sweden
    Scand J Surg 93:223-8. 2004
    ..The aim with this study was to measure whether augmentation with resorbable calcium-phosphate cement could improve fracture stability as shown in biomechanical studies...
  41. ncbi request reprint Resorbable cement for the augmentation of internally-fixed unstable trochanteric fractures. A prospective, randomised multicentre study
    P Mattsson
    Department of Orthopaedics, Uppsala University Hospital, S 75185 Uppsala, Sweden
    J Bone Joint Surg Br 87:1203-9. 2005
    ....
  42. ncbi request reprint The significance of radiolucent zones surrounding pedicle screws. Definition of screw loosening in spinal instrumentation
    B Sanden
    Department of Orthopaedic Surgery, Uppsala University, Sweden
    J Bone Joint Surg Br 86:457-61. 2004
    ..0002). Our findings showed that all screws with radiolucent zones had low extraction torques or low pull-out resistance. A radiolucent zone is a good indicator of loosening of a pedicle screw...
  43. ncbi request reprint Stability of cemented all-polyethylene keeled glenoid components. A radiostereometric study with a two-year follow-up
    H Rahme
    Department of Orthopaedics, Uppsala University Hospital, Uppsala, Sweden
    J Bone Joint Surg Br 86:856-60. 2004
    ..In ten shoulders rotation exceeded 2 degrees in one or more axes with retroversion/anteversion being most common. No correlation was found between migration and the presence of radiolucencies on conventional radiographs...
  44. ncbi request reprint RSA applications in monitoring of fracture healing in clinical trials
    R Madanat
    Orthopaedic Research Unit, Department of Orthopaedic Surgery and Traumatology, University of Turku, Turku, Finland
    Scand J Surg 95:119-27. 2006
    ..The RSA method may serve as a scientific tool to accurately evaluate the significance of supporting novel biomaterials for the early stability and the rate of healing in fractures...
  45. ncbi request reprint Hydroxyapatite coating improves fixation of pedicle screws. A clinical study
    B Sanden
    Department of Orthopaedic Surgery, Uppsala University Hospital, Sweden
    J Bone Joint Surg Br 84:387-91. 2002
    ..001). There were more radiolucent zones surrounding the uncoated screws than the HA-coated screws (p < 0.001). HA coating of pedicle screws resulted in improved fixation with reduced risk of loosening of the screws...
  46. ncbi request reprint Feather pecking in chickens is genetically related to behavioural and developmental traits
    P Jensen
    IFM Biology, Linkoping University, Sweden
    Physiol Behav 86:52-60. 2005
    ..Hence, a wide array of behavioural and developmental traits were genetically linked to FP...
  47. ncbi request reprint Unrestricted weight bearing and intensive physiotherapy after uncemented total hip arthroplasty
    H Strom
    Department of Orthopaedics, University of Uppsala, Sweden
    Scand J Surg 95:55-60. 2006
    ..The effectiveness of partial weightbearing after hip surgery has been questioned as well as the need of intensive physiotherapy...