D Larhammar

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. pmc Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates
    Gorel Sundstrom
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    PLoS ONE 5:e10512. 2010
  2. pmc Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a, and Y8b
    Gorel Sundstrom
    Department of Neuroscience, Uppsala University Uppsala, Sweden
    Front Neurosci 7:29. 2013
  3. pmc The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications
    David Lagman
    Department of Neuroscience, Science for Life Laboratory, Uppsala University, Box 593, SE 75124 Uppsala, Sweden
    BMC Evol Biol 13:238. 2013
  4. pmc The evolution of vertebrate somatostatin receptors and their gene regions involves extensive chromosomal rearrangements
    Daniel Ocampo Daza
    Department of Neuroscience, Science for Life Laboratory, Uppsala universitet, Box 593, SE 75124 Uppsala, Sweden
    BMC Evol Biol 12:231. 2012
  5. pmc Early vertebrate chromosome duplications and the evolution of the neuropeptide Y receptor gene regions
    Tomas A Larsson
    Department of Neuroscience, Uppsala University, Box 593, 75124 Uppsala, Sweden
    BMC Evol Biol 8:184. 2008
  6. pmc Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters
    Gorel Sundstrom
    Department of Neuroscience, Uppsala University, Box 593, 75124 Uppsala, Sweden
    BMC Evol Biol 8:254. 2008
  7. pmc Evolution of vertebrate rod and cone phototransduction genes
    Dan Larhammar
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, SE 751 24 Uppsala, Sweden
    Philos Trans R Soc Lond B Biol Sci 364:2867-80. 2009
  8. ncbi request reprint Origins of the many NPY-family receptors in mammals
    D Larhammar
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 593, S 75124, Uppsala, Sweden
    Peptides 22:295-307. 2001
  9. doi request reprint Early duplications of opioid receptor and Peptide genes in vertebrate evolution
    Dan Larhammar
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Ann N Y Acad Sci 1163:451-3. 2009
  10. doi request reprint Major genomic events and their consequences for vertebrate evolution and endocrinology
    Dan Larhammar
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Ann N Y Acad Sci 1163:201-8. 2009

Collaborators

Detail Information

Publications87

  1. pmc Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates
    Gorel Sundstrom
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    PLoS ONE 5:e10512. 2010
    ..Previously we have described how two rounds of genome doubling (2R) before the origin of jawed vertebrates formed the receptor family...
  2. pmc Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a, and Y8b
    Gorel Sundstrom
    Department of Neuroscience, Uppsala University Uppsala, Sweden
    Front Neurosci 7:29. 2013
    ..All peptides and receptors have higher expression in heart, kidney, and brain. These quantitative aspects on receptor affinities and mRNA distribution help provide a more complete picture of the NPY system...
  3. pmc The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications
    David Lagman
    Department of Neuroscience, Science for Life Laboratory, Uppsala University, Box 593, SE 75124 Uppsala, Sweden
    BMC Evol Biol 13:238. 2013
    ....
  4. pmc The evolution of vertebrate somatostatin receptors and their gene regions involves extensive chromosomal rearrangements
    Daniel Ocampo Daza
    Department of Neuroscience, Science for Life Laboratory, Uppsala universitet, Box 593, SE 75124 Uppsala, Sweden
    BMC Evol Biol 12:231. 2012
    ..To resolve their evolution in vertebrates we have investigated the SSTR genes and a large number of adjacent gene families by phylogeny and conserved synteny analyses in a broad range of vertebrate species...
  5. pmc Early vertebrate chromosome duplications and the evolution of the neuropeptide Y receptor gene regions
    Tomas A Larsson
    Department of Neuroscience, Uppsala University, Box 593, 75124 Uppsala, Sweden
    BMC Evol Biol 8:184. 2008
    ..These correspond to Homo sapiens chromosomes 4, 5, 8 and 10...
  6. pmc Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters
    Gorel Sundstrom
    Department of Neuroscience, Uppsala University, Box 593, 75124 Uppsala, Sweden
    BMC Evol Biol 8:254. 2008
    ..Our starting point was the gene family for the NPY family of peptides located near the Hox clusters in the pufferfish Takifugu rubripes, the zebrafish Danio rerio, and human...
  7. pmc Evolution of vertebrate rod and cone phototransduction genes
    Dan Larhammar
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, SE 751 24 Uppsala, Sweden
    Philos Trans R Soc Lond B Biol Sci 364:2867-80. 2009
    ..The implications of the many early vertebrate gene duplications for functional specialization of specific retinal cell types, particularly cones and rods, are discussed...
  8. ncbi request reprint Origins of the many NPY-family receptors in mammals
    D Larhammar
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 593, S 75124, Uppsala, Sweden
    Peptides 22:295-307. 2001
    ..The roles of Y(1) and Y(5) in feeding may differ between species demonstrating the importance of performing functional studies in additional mammals to mouse and rat...
  9. doi request reprint Early duplications of opioid receptor and Peptide genes in vertebrate evolution
    Dan Larhammar
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Ann N Y Acad Sci 1163:451-3. 2009
    ..Thus the system of opioid peptides and receptors was already established approximately 450 Ma at the dawn of gnathostome evolution...
  10. doi request reprint Major genomic events and their consequences for vertebrate evolution and endocrinology
    Dan Larhammar
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Ann N Y Acad Sci 1163:201-8. 2009
    ..We review here some peptide families (neuropeptide Y, oxytocin-vasopressin, and somatostatin) where genomic information helps simplify nomenclature. This approach is useful also for other gene families, such as peptide receptors...
  11. pmc The human Hox-bearing chromosome regions did arise by block or chromosome (or even genome) duplications
    Dan Larhammar
    Unit of Pharmacology, Uppsala University, SE 75124 Uppsala, Sweden
    Genome Res 12:1910-20. 2002
    ..We conclude that all relevant and analyzable families support or are consistent with block/chromosome duplications and that none clearly contradicts the 2R hypothesis...
  12. ncbi request reprint Molecular evolution of NPY receptor subtypes
    D Larhammar
    Department of Neuroscience, Unit of Pharmacology, Box 593 Uppsala University, SE 75124 Uppsala, Sweden
    Neuropeptides 38:141-51. 2004
    ..Changes in anatomical distribution of receptor expression may have played an important part in such functional switching along with changes in receptor structures and ligand preferences...
  13. ncbi request reprint Novel neuropeptide Y Y2-like receptor subtype in zebrafish and frogs supports early vertebrate chromosome duplications
    R Fredriksson
    Department of Neuroscience, Uppsala University, Box 593, SE 75124, Uppsala, Sweden
    J Mol Evol 58:106-14. 2004
    ..The Y7 receptor supports the theory of early vertebrate genome duplications and suggests that the Y family of receptors is a result of these early genome duplications...
  14. ncbi request reprint Neuropeptide Y receptor subtype with unique properties cloned in the zebrafish: the zYa receptor
    P Starbäck
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 593, SE 75124, Uppsala, Sweden
    Brain Res Mol Brain Res 70:242-52. 1999
    ..Thus, the sequence comparisons, pharmacological properties, and chromosomal localization suggest that the zYa receptor is a novel NPY receptor subtype which is likely to be present also in mammals...
  15. ncbi request reprint Cloning and characterization of a zebrafish Y2 receptor
    R Fredriksson
    Department of Neuroscience, Uppsala University, Box 593, SE 75124, Uppsala, Sweden
    Regul Pept 133:32-40. 2006
    ..Y2 from zebrafish binds very poorly to the Y2-specific antagonist BIIE0246. Our pharmacological characterization supports our previous conclusions regarding the binding pocket of BIIE0246 in the human Y2 receptor...
  16. ncbi request reprint Chicken neuropeptide Y receptor Y2: structural and pharmacological differences to mammalian Y2(1)
    E Salaneck
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Sweden
    FEBS Lett 484:229-34. 2000
    ....
  17. ncbi request reprint Cloning of a neuropeptide Y/peptide YY receptor from the Atlantic cod: the Yb receptor
    A K Arvidsson
    Department of Neuroscience, Uppsala University, Sweden
    Regul Pept 75:39-43. 1998
    ..The five cloned mammalian NPY-family receptors and the three cloned zebrafish NPY receptors indicate that this is the largest receptor family among all peptide receptors that belong to the superfamily of G protein-coupled receptors...
  18. ncbi request reprint Chicken neuropeptide Y-family receptor Y4: a receptor with equal affinity for pancreatic polypeptide, neuropeptide Y and peptide YY
    I Lundell
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 593, S 751 24 Uppsala, Sweden
    J Mol Endocrinol 28:225-35. 2002
    ..Thus the chicken Y4 receptor is less selective and anatomically more widespread than that in mammals, probably reflecting the original properties of the Y4 receptor...
  19. ncbi request reprint A neuropeptide Y receptor Y1-subfamily gene from an agnathan, the European river lamprey. A potential ancestral gene
    E Salaneck
    Unit of Pharmacology, Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Eur J Biochem 268:6146-54. 2001
    ..This lamprey receptor is evolutionarily the most distant NPY receptor that clearly belongs to the Y1 subfamily as defined in mammals, which shows that subtypes Y2 and Y5 arose even earlier in evolution...
  20. ncbi request reprint Studies of the human, rat, and guinea pig Y4 receptors using neuropeptide Y analogues and two distinct radioligands
    M M Berglund
    Dept. of Neuroscience, Pharmacology, Uppsala University, Box 593, SE-75124, Uppsala, Sweden
    Peptides 22:351-6. 2001
    ..These results suggest that different full agonists can distinguish between different active conformations of the gpY4 receptor and that Y4 may display functional differences in vivo between human, guinea pig, and rat...
  21. ncbi request reprint Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT(1B) receptor
    C Granas
    Department of Neuroscience, Uppsala University, Sweden
    Eur J Pharmacol 380:171-81. 1999
    ..However, some notable differences also emerge showing that functional roles of individual amino acid residues must be tested experimentally in each receptor subtype...
  22. ncbi request reprint Cloning and characterization of the guinea pig neuropeptide Y receptor Y5
    I Lundell
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 593, S 751 24, Uppsala, Sweden
    Peptides 22:357-63. 2001
    ..Thus the pharmacological profile of the guinea pig Y5 receptor agrees well with that reported for the Y5 receptor from other cloned species...
  23. ncbi request reprint The cloned guinea pig neuropeptide Y receptor Y1 conforms to other mammalian Y1 receptors
    M M Berglund
    Department of Neuroscience, Pharmacology, Uppsala University, Sweden
    Peptides 20:1043-53. 1999
    ..Thus, results from previous studies on guinea pig NPY receptors might imply the existence of an additional Y1-like receptor sensitive to B1BP3226...
  24. ncbi request reprint The cloned guinea pig pancreatic polypeptide receptor Y4 resembles more the human Y4 than does the rat Y4
    H Eriksson
    Department of Neuroscience, Uppsala University, Sweden
    Regul Pept 75:29-37. 1998
    ..This agrees with the greater identity between guinea pig and human PP compared to rat PP. These comparisons suggest that the rodent PPs and Y4 receptors have an accelerated replacement rate...
  25. pmc The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor
    I Lundell
    Department of Medical Pharmacology, Uppsala University, Sweden
    Proc Natl Acad Sci U S A 93:5111-5. 1996
    ..Interestingly, the amino acid sequence identity between rat and human PP1 is only 75%. Thus, the sequence, the tissue distribution, and the binding profile of the PP1 receptor differ considerably between rat and human...
  26. ncbi request reprint Uneven evolutionary rates of bradykinin B1 and B2 receptors in vertebrate lineages
    T Bromée
    Department of Neuroscience, Pharmacology, Uppsala University, P O Box 593, SE 751 24 Uppsala, Sweden
    Gene 373:100-8. 2006
    ..In conclusion, the receptor tandem duplication predates the divergence of ray-finned fish and tetrapods and no additional duplicates of the receptors or bradykinin seem to have survived the ray-finned fish tetraploidization...
  27. ncbi request reprint Birth and death of neuropeptide Y receptor genes in relation to the teleost fish tetraploidization
    E Salaneck
    Department of Neuroscience, Uppsala University, Box 593, SE 75124 Uppsala, Sweden
    Gene 409:61-71. 2008
    ....
  28. ncbi request reprint A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells
    E E Jazin
    Department of Medical Genetics, Uppsala University, Sweden
    Regul Pept 47:247-58. 1993
    ..Our results show that hFB22 and LCR1 do not encode NPY receptors, and their true ligand(s) remains to be identified...
  29. ncbi request reprint Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide
    D Larhammar
    Department of Medical Pharmacology, Uppsala University, Sweden
    Regul Pept 62:1-11. 1996
    ..The emergence of sequence information for several receptor subtypes from various species will shed additional light on the evolution of the functions of the NPY-family peptides...
  30. ncbi request reprint Neuropeptide Y receptor gene y6: multiple deaths or resurrections?
    P Starbäck
    Department of Neuroscience, Uppsala University, Uppsala, SE 75124, Sweden
    Biochem Biophys Res Commun 277:264-9. 2000
    ..In either case, the y6 gene has a quite unusual evolutionary history with multiple independent deaths or resurrections...
  31. ncbi request reprint Cloning and functional expression of the guinea pig neuropeptide Y Y2 receptor
    P Sharma
    Department of Neuroscience, Uppsala University, Sweden
    Regul Pept 75:23-8. 1998
    ..Thus, the guinea pig Y2 receptor is well conserved in comparison with human and rat with regard to both amino acid sequence and pharmacological profile...
  32. ncbi request reprint Complex gene organization of synaptic protein SNAP-25 in Drosophila melanogaster
    C Risinger
    Department of Medical Pharmacology, Uppsala University, Sweden
    Gene 194:169-77. 1997
    ....
  33. pmc Cloning, structural characterization and functional expression of a zebrafish bradykinin B2-related receptor
    Torun Dunér
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, P O Box 593, SE 751 24 Uppsala, Sweden
    Biochem J 364:817-24. 2002
    ..The B1-selective analogue [Arg0,Trp5,Leu8,des-Arg9]-BK was inactive at nanomolar concentrations. Taken together, these results strongly support the gene's identity as a piscine orthologue of the mammalian B2 receptor...
  34. ncbi request reprint Evolution of the neuropeptide Y family: new genes by chromosome duplications in early vertebrates and in teleost fishes
    Gorel Sundstrom
    Department of Neuroscience, Uppsala University, Box 593, 75124 Uppsala, Sweden
    Gen Comp Endocrinol 155:705-16. 2008
    ..Our study shows that when sequence comparisons give ambiguous results, chromosomal location can serve as a useful criterion to identify orthologs. This strategy may help to resolve relationships in several families of short peptides...
  35. ncbi request reprint Binding of chimeric NPY/galanin peptides M32 and M242 to cloned neuropeptide Y receptor subtypes Y1, Y2, Y4, and Y5
    M M Berglund
    Department of Neuroscience, Pharmacology, Uppsala University, Uppsala, Sweden
    Neuropeptides 35:148-53. 2001
    ..This suggests that the galanin portion of M32 influences and/or stabilizes the conformation of the NPY portion, similar to the effect seen for the NPY portion of M32 in binding to galanin receptors...
  36. pmc Evolution of the neuropeptide Y receptor family: gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig
    A Wraith
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, SE 751 24 Uppsala, Sweden
    Genome Res 10:302-10. 2000
    ..Thus, these gene families have expanded through large-scale duplications. The sequence comparisons show that the NPY receptor triplet NPY1R-NPY2R-NPY5R existed before these large-scale duplications...
  37. ncbi request reprint Neuropeptide Y-family receptors Y6 and Y7 in chicken. Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region
    Torun Bromée
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Sweden
    FEBS J 273:2048-63. 2006
    ..The physiological roles of Y6 and Y7 remain to be identified, but our phylogenetic and chromosomal analyses support the ancient origin of these Y receptor genes by chromosome duplications in an early (pregnathostome) vertebrate ancestor...
  38. ncbi request reprint Site-directed mutagenesis of the human 5-HT1B receptor
    C Granas
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Sweden
    Eur J Pharmacol 349:367-75. 1998
    ..Mutation of F354 in transmembrane region VII, which differs between receptor subtypes, increased the affinity of methiothepin 2-3-fold but the affinities of the other compounds tested were essentially unchanged...
  39. ncbi request reprint Evolutionary conservation of synaptosome-associated protein 25 kDa (SNAP-25) shown by Drosophila and Torpedo cDNA clones
    C Risinger
    Department of Medical Genetics, Uppsala University, Sweden
    J Biol Chem 268:24408-14. 1993
    ..This supports the existence of a basic molecular machinery for synaptic vesicle docking in vertebrate and invertebrate synapses...
  40. doi request reprint Characterization of the neuropeptide Y system in the frog Silurana tropicalis (Pipidae): three peptides and six receptor subtypes
    G Sundstrom
    Department of Neuroscience, Uppsala University, Box 593, SE 75124 Uppsala, Sweden
    Gen Comp Endocrinol 177:322-31. 2012
    ..In conclusion, our characterization of the NPY system in S. tropicalis with its six receptors demonstrates not only greater complexity than in mammals but also some interesting differences in ligand-receptor preferences...
  41. ncbi request reprint Structural diversity of receptors for neuropeptide Y, peptide YY and pancreatic polypeptide
    D Larhammar
    Department of Medical Pharmacology, Uppsala University, Sweden
    Regul Pept 65:165-74. 1996
    ..Thus, within the same family there are highly conserved receptors and peptide ligands as well as one rapidly evolving receptor and ligand...
  42. ncbi request reprint Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY
    I Lundell
    Department of Medical Pharmacology, Uppsala University, Sweden
    J Biol Chem 270:29123-8. 1995
    ..As all three peptides are present in the gut through either endocrine release or innervation, all three peptides may be physiological ligands to the novel NPY family receptor PP1...
  43. ncbi request reprint Pufferfish and zebrafish have five distinct NPY receptor subtypes, but have lost appetite receptors Y1 and Y5
    Tomas A Larsson
    Department of Neuroscience, Uppsala University, Sweden
    Ann N Y Acad Sci 1040:375-7. 2005
    ..These results reveal interesting differences in the NPY system of teleosts and mammals that may have arisen in the genetic turmoil involving the basal ray-fin fish tetraploidization...
  44. ncbi request reprint One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology
    Aneta Ringholm
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, BMC, 75 124 Uppsala, Sweden
    J Neurochem 82:6-18. 2002
    ....
  45. ncbi request reprint Pharmacological characterization of cloned chicken neuropeptide Y receptors Y1 and Y5
    Sara K S Holmberg
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Uppsala, Sweden
    J Neurochem 81:462-71. 2002
    ..These results suggest that some of the selective Y1 and Y5 antagonists developed in mammals can be used to study appetite regulation in chicken...
  46. pmc Strong evolutionary conservation of neuropeptide Y: sequences of chicken, goldfish, and Torpedo marmorata DNA clones
    A G Blomqvist
    Department of Medical Genetics, Uppsala University, Sweden
    Proc Natl Acad Sci U S A 89:2350-4. 1992
    ..The 30-amino acid carboxyl-terminal extension of the NPY precursor also displays considerable sequence conservation. These results show that NPY is one of the most highly conserved neuroendocrine peptides...
  47. ncbi request reprint Site-directed mutagenesis of the 5-HT1B receptor increases the affinity of 5-HT for the agonist low-affinity conformation and reduces the intrinsic activity of 5-HT
    C Granas
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 593, SE 751 24, Uppsala, Sweden
    Eur J Pharmacol 421:69-76. 2001
    ..In conclusion, these results show that single amino acid substitutions can selectively change the affinity of 5-HT for the G protein uncoupled conformation of the 5-HT1B receptor and alter the intrinsic activity of the ligand...
  48. ncbi request reprint Co-localized neuropeptide Y and GABA have complementary presynaptic effects on sensory synaptic transmission
    D Parker
    Department of Neuroscience, The Karolinska Institute, Stockholm, Sweden
    Eur J Neurosci 10:2856-70. 1998
    ..We conclude that NPY and GABA are colocalized in terminals in the dorsal spinal cord of the lamprey, and that they have complementary actions in modulating sensory inputs...
  49. ncbi request reprint Reciprocal mutations of neuropeptide Y receptor Y2 in human and chicken identify amino acids important for antagonist binding
    Magnus M Berglund
    Department of Neuroscience, Pharmacology, Uppsala University, Box 593, SE 75224, Uppsala, Sweden
    FEBS Lett 518:5-9. 2002
    ..These results will be useful for construction of three-dimensional models of the widely divergent NPY receptor subtypes...
  50. ncbi request reprint Effects of a teleost tetraploidization on neuropeptide Y receptor gene repertoire in ray-finned fishes
    Erik Salaneck
    Department of Neuroscience, Uppsala University, Sweden
    Ann N Y Acad Sci 1040:457-9. 2005
    ..These dramatic alterations of the teleost receptor repertoire may be related to the tetraploidization in a teleost ancestor...
  51. pmc Evolution of vertebrate opioid receptors
    Susanne Dreborg
    Department of Neuroscience, Uppsala University, Box 593, SE 75124 Uppsala, Sweden
    Proc Natl Acad Sci U S A 105:15487-92. 2008
    ..Interestingly, the ancestral receptor gene duplications coincide with the origin of the four opioid peptide precursor genes. Thus, the complete vertebrate opioid system was already established in the first jawed vertebrates...
  52. ncbi request reprint Three neuropeptide Y receptor genes in the spiny dogfish, Squalus acanthias, support en bloc duplications in early vertebrate evolution
    Erik Salaneck
    Department of Neuroscience, Unit of Pharmacology, Evolutionary Biology Center, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 20:1271-80. 2003
    ....
  53. ncbi request reprint Mutational analysis of the Acropora millepora PaxD paired domain highlights the importance of the linker region for DNA binding
    Karin Nordström
    Department of Neuroscience, Pharmacology, Uppsala University, Box 593, Uppsala 751 24, Sweden
    Gene 320:81-7. 2003
    ..The PaxD data thus highlight the importance of the linker region, and particularly G70 and S71, in DNA binding by Pax proteins...
  54. pmc Cloning, tissue distribution, pharmacology and three-dimensional modelling of melanocortin receptors 4 and 5 in rainbow trout suggest close evolutionary relationship of these subtypes
    Tatjana Haitina
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, BMC, Uppsala SE75124, Sweden
    Biochem J 380:475-86. 2004
    ....
  55. ncbi request reprint Characterization of three separated exons in the HLA class II DR region of the human major histocompatibility complex
    A K Arvidsson
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Hum Immunol 42:254-64. 1995
    ..These selectively neutral exons may serve as useful markers for tracing the phylogeny of HLA haplotypes...
  56. ncbi request reprint Cloning and sequence analysis of a neuropeptide Y/peptide YY receptor Y1 cDNA from Xenopus laevis
    A G Blomqvist
    Department of Medical Genetics, Uppsala University, Sweden
    Biochim Biophys Acta 1261:439-41. 1995
    ..The intracellular regions including the carboxy-terminal tail are nearly identical between Xenopus and mammals, suggesting strong structural constraints on the portions that may interact with G proteins...
  57. ncbi request reprint Characterization of NPY receptor subtypes Y2 and Y7 in rainbow trout Oncorhynchus mykiss
    Tomas A Larsson
    Department of Neuroscience, Uppsala University, Box 593, SE 75124, Uppsala, Sweden
    Peptides 27:1320-7. 2006
    ..They also reveal appreciable differences in the repertoire and characteristics of NPY receptors between fish and tetrapods stressing the importance of lineage-specific gene loss as well as sequence divergence after duplication...
  58. ncbi request reprint Extensive duplications of phototransduction genes in early vertebrate evolution correlate with block (chromosome) duplications
    Karin Nordström
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 593, SE 751 24 Uppsala, Sweden
    Genomics 83:852-72. 2004
    ..We conclude that gene duplications in early vertebrate evolution probably helped facilitate the specialization of the retina and the subspecialization of different retinal cell types...
  59. ncbi request reprint Cloning and sequence analysis of the neuropeptide Y receptors Y5 and Y6 in the coelacanth Latimeria chalumnae
    Tomas A Larsson
    Department of Neuroscience, Uppsala University, Box 593, SE 75124, Uppsala, Sweden
    Gen Comp Endocrinol 150:337-42. 2007
    ..The Y6 receptor is also missing in teleost fishes. Our results confirm an early vertebrate origin for all NPY receptor subtypes presently found in mammals followed by differential gene loss in the different classes of vertebrates...
  60. ncbi request reprint Neuropeptide Y-family peptides and receptors in the elephant shark, Callorhinchus milii confirm gene duplications before the gnathostome radiation
    Tomas A Larsson
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Genomics 93:254-60. 2009
    ....
  61. doi request reprint Evolution of the growth hormone-prolactin-somatolactin system in relation to vertebrate tetraploidizations
    Daniel Ocampo Daza
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Ann N Y Acad Sci 1163:491-3. 2009
    ..These analyses show that both the peptide and receptor families were formed through local duplications in early vertebrate evolution and chromosome duplications...
  62. ncbi request reprint Remarkable synteny conservation of melanocortin receptors in chicken, human, and other vertebrates
    Helgi B Schioth
    Department of Neuroscience, Uppsala University, BMC, Box 593, 751 24 Uppsala, Sweden
    Genomics 81:504-9. 2003
    ..Analysis of conserved synteny with mammalian genomes and paralogon segments prompted us to predict an ancestral gene organization that may explain how this family was formed through both local duplication and tetraploidization processes...
  63. pmc Re-evaluation of receptor-ligand interactions of the human neuropeptide Y receptor Y1: a site-directed mutagenesis study
    Paula Sjödin
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 593, SE 75124 Uppsala, Sweden
    Biochem J 393:161-9. 2006
    ..Our mutagenesis results and our three-dimensional model of the receptor based on the high-resolution structure of bovine rhodopsin suggest new interactions for agonist as well as antagonist binding to the Y1 receptor...
  64. ncbi request reprint Numerous groups of chromosomal regional paralogies strongly indicate two genome doublings at the root of the vertebrates
    Lars Gustav Lundin
    Department of Neuroscience, BMC, Uppsala University, S 751 24 Uppsala, Sweden
    J Struct Funct Genomics 3:53-63. 2003
    ..Furthermore, the topographical relations of some paralogy groups are discussed...
  65. ncbi request reprint Bradykinin receptors in the zebrafish (Danio rerio)
    Torun Bromée
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Sweden
    Ann N Y Acad Sci 1040:246-8. 2005
    ..The results increase our understanding of the evolution of BK receptors and their ligands...
  66. ncbi request reprint Cloning, pharmacology, and distribution of the neuropeptide Y-receptor Yb in rainbow trout
    Earl T Larson
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 593, SE 75124 Uppsala, Sweden
    Peptides 24:385-95. 2003
    ..The expression of the receptor in the hypothalamus and telencephalon suggests a possible role in these processes. This and other receptors from this species have potential for improving aquaculture...
  67. pmc Pharmacological characterization of ligand-receptor interactions at the zebrafish bradykinin receptor
    Torun Bromée
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 593, SE 75124 Uppsala, Sweden
    Br J Pharmacol 144:11-6. 2005
    ..These results increase our understanding of the evolution of BK receptors and the functions of the kallikrein-kinin system...
  68. ncbi request reprint Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central melanocortin system
    Aneta Ringholm
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Eur J Biochem 270:213-21. 2003
    ..Conservation of gene structure, pharmacological properties and tissue distribution suggests that this receptor may have similar roles in sharks as in mammals and that these were established more than 450 million years ago...
  69. ncbi request reprint Ray-fin fish tetraploidization gave rise to pufferfish duplicates of NPY and PYY, but zebrafish NPY duplicate was lost
    Gorel Sundstrom
    Department of Neuroscience, Uppsala University, Sweden
    Ann N Y Acad Sci 1040:476-8. 2005
    ..The two fugu NPY genes are predominantly expressed in brain. The two PYY genes are expressed in a broad range of tissues including brain and gonads. Thus, the NPY system appears to be more complex in teleosts than in tetrapods...
  70. ncbi request reprint Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type
    D Larhammar
    Department of Medical Genetics, Uppsala University, Sweden
    J Biol Chem 267:10935-8. 1992
    ....
  71. ncbi request reprint Characterization of antibodies to synthetic nerve growth factor (NGF) and proNGF peptides
    T Ebendal
    Department of Developmental Biology, Uppsala University, Sweden
    J Neurosci Res 22:223-40. 1989
    ..Immunohistochemically, both peptide antisera against the pro-NGF stained the perinuclear cytoplasm in the basal part of the cells of the granulated convoluted tubules in the mouse submandibular gland.(ABSTRACT TRUNCATED AT 400 WORDS)..
  72. ncbi request reprint Embryonic expression of the mRNA for the rat homologue of the fusin/CXCR-4 HIV-1 co-receptor
    E E Jazin
    Department of Medical Genetics, Uppsala University, Sweden
    J Neuroimmunol 79:148-54. 1997
    ....
  73. ncbi request reprint Peptide hormone and receptor evolution
    Dan Larhammar
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 593, SE 75124 Uppsala, Sweden
    Gen Comp Endocrinol 153:147. 2007
  74. pmc Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig
    Anne Lecklin
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 593, S 75124 Uppsala, Sweden
    Br J Pharmacol 135:2029-37. 2002
    ..As the guinea-pig is very distantly related to the rat and mouse, this suggests that both Y(1) and Y(5) receptors may mediate NPY-induced hyperphagia also in other orders of mammals...
  75. pmc Agonists for neuropeptide Y receptors Y1 and Y5 stimulate different phases of feeding in guinea pigs
    Anne Lecklin
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 593, S 75124 Uppsala, Sweden
    Br J Pharmacol 139:1433-40. 2003
    ..As the action profiles of the Y(1) and Y(5) agonists on feeding parameters were different, it seems that they influence different phases of eating...
  76. ncbi request reprint Pharmacological comparison of rat and human melanocortin 3 and 4 receptors in vitro
    Helgi B Schioth
    Department of Neuroscience, Biomedical Center, Box 593, 751 24 Uppsala University, Uppsala, Sweden
    Regul Pept 106:7-12. 2002
    ..Pharmacological species difference have earlier been reported for the MC1 and MC5 receptors but this is the first report showing important differences between the rat and human MC4 receptors...
  77. doi request reprint Evolution of the insulin-like growth factor binding protein (IGFBP) family
    Daniel Ocampo Daza
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Endocrinology 152:2278-89. 2011
    ..The large degree of retention of IGFBP genes after the ancient expansion of the gene family strongly suggests that each gene evolved distinct and important functions early in vertebrate evolution...
  78. ncbi request reprint Localization of neuropeptide Y receptor Y5 mRNA in the guinea pig brain by in situ hybridization
    Sara K S Holmberg
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 593, SE 751 24 Uppsala, Sweden
    Regul Pept 117:61-7. 2004
    ....
  79. ncbi request reprint Developmental expression of NPY/PYY receptors zYb and zYc in zebrafish
    Maura Mathieu
    Department of Experimental Biology, University of Genova, Italy
    Ann N Y Acad Sci 1040:399-401. 2005
    ..These results show that zYb and zYc receptors are expressed during ontogeny, suggesting a role for neuropeptide Y (NPY) and/or peptide YY (PYY) in organogenesis...
  80. ncbi request reprint The evolution of neuroendocrine peptides
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Gen Comp Endocrinol 142:53-9. 2005
    ....
  81. ncbi request reprint Neuropeptide Y inhibits the biosynthesis of sulfated neurosteroids in the hypothalamus through activation of Y(1) receptors
    Delphine Beaujean
    European Institute for Peptide Research IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U 413, UA Centre National de la Recherche Scientifique, University of Rouen, 76821 Mont Saint Aignan, France
    Endocrinology 143:1950-63. 2002
    ..Our data also demonstrate that NPY, acting via Y(1) receptors, exerts an inhibitory effect on the biosynthesis of sulfated neurosteroids...
  82. ncbi request reprint Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish
    Jori O Ruuskanen
    Department of Pharmacology and Clinical Pharmacology, Turku Graduate School of Biomedical Sciences, University of Turku, Finland
    Mol Biol Evol 21:14-28. 2004
    ....
  83. ncbi request reprint Neuropeptide Y inhibits spontaneous alpha-melanocyte-stimulating hormone (alpha-MSH) release via a Y(5) receptor and suppresses thyrotropin-releasing hormone-induced alpha-MSH secretion via a Y(1) receptor in frog melanotrope cells
    Ludovic Galas
    European Institute for Peptide Research IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM, U 413, UA Centre National de la Recherche Scientifique, University of Rouen, 76821 Mont Saint Aignan, France
    Endocrinology 143:1686-94. 2002
    ....
  84. ncbi request reprint Comparative genomics by capture PCR
    Maria Lagerstrom-Fermer
    Department of Medical Sciences, Unit of Molecular Medicine, University Hospital, Uppsala, Sweden Maria
    Genomics 79:432-6. 2002
    ..In conclusion, we present a useful procedure to reveal functionally relevant sequence elements, and to select primers for amplification of homologous sequences from a wide range of species...
  85. ncbi request reprint Neuropeptide Y effects on vasorelaxation and intestinal contraction in the Atlantic cod Gadus morhua
    Fatemeh Shahbazi
    Department of Zoophysiology, Goteborg University, SE 405 30 Goteborg, Sweden
    Am J Physiol Regul Integr Comp Physiol 282:R1414-21. 2002
    ..A physiological role for NPY in teleost vasculature is concluded, but surprisingly the effect, a vasodilation, is opposite to that in mammals and is mediated by prostaglandins...
  86. ncbi request reprint [Blood group diet: fantasy and quackery]
    Karin D Nylun
    Dietistprogrammet, Uppsala universitet
    Lakartidningen 101:3168, 3171-2. 2004