Kjellen L, Lindahl U. Specificity of glycosaminoglycan-protein interactions. Curr Opin Struct Biol. 2018;50:101-108 pubmed publisher
..Studies of heparan sulfate biosynthesis point to stochastic but strictly regulated, cell-specific polymer modification. Together, these features allow for graded modulation of protein functional response. ..
..Together our results strongly indicate that not only the level, but also the structure of HS is critical in regulating the distribution and signaling activity of Ihh in chondrocytes. ..
Deligny A, Dierker T, Dagälv A, Lundequist A, Eriksson I, Nairn A, et al. NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length. J Biol Chem. 2016;291:18600-18607 pubmed publisher
..A model is discussed where NDST2-specific substrate modification stimulates elongation resulting in increased heparan sulfate chain length. ..