Jonas Jarvius

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. ncbi request reprint DNA Skyline: fonts to facilitate visual inspection of nucleic acid sequences
    Jonas Jarvius
    Uppsala University, Department of Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    Biotechniques 40:740. 2006
  2. ncbi request reprint Prospects for in situ analyses of individual and complexes of DNA, RNA, and protein molecules with padlock and proximity probes
    Ulf Landegren
    Department of Genetics and Pathology, University of Uppsala, S 751 85 Uppsala, Sweden
    Methods Cell Biol 75:787-97. 2004
  3. ncbi request reprint Proximity ligation assays for sensitive and specific protein analyses
    Sigrun M Gustafsdottir
    Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, SE 75185 Uppsala, Sweden
    Anal Biochem 345:2-9. 2005
  4. ncbi request reprint Molecular tools for a molecular medicine: analyzing genes, transcripts and proteins using padlock and proximity probes
    Ulf Landegren
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
    J Mol Recognit 17:194-7. 2004
  5. pmc A dual-tag microarray platform for high-performance nucleic acid and protein analyses
    Olle Ericsson
    Department of Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, SE 75185 Uppsala, Sweden
    Nucleic Acids Res 36:e45. 2008
  6. pmc Rapid identification of bio-molecules applied for detection of biosecurity agents using rolling circle amplification
    Jenny Göransson
    tRudbeck Laboratory, Department of Immunology, Genetics and Pathology, SciLifeLab, Uppsala University, Uppsala, Sweden
    PLoS ONE 7:e31068. 2012
  7. ncbi request reprint A sense of closeness: protein detection by proximity ligation
    Mats Gullberg
    The Beijer Laboratory, Department of Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    Curr Opin Biotechnol 14:82-6. 2003
  8. pmc Cytokine detection by antibody-based proximity ligation
    Mats Gullberg
    The Beijer Laboratory, Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 75185 Uppsala, Sweden
    Proc Natl Acad Sci U S A 101:8420-4. 2004
  9. doi request reprint Ligation-based molecular tools for lab-on-a-chip devices
    Jonas Melin
    Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, SE 75185 Uppsala, Sweden
    N Biotechnol 25:42-8. 2008
  10. ncbi request reprint Proximity ligation: a specific and versatile tool for the proteomic era
    Ola Söderberg
    University of Uppsala, Department of Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    Genet Eng (N Y) 28:85-93. 2007

Collaborators

Detail Information

Publications20

  1. ncbi request reprint DNA Skyline: fonts to facilitate visual inspection of nucleic acid sequences
    Jonas Jarvius
    Uppsala University, Department of Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    Biotechniques 40:740. 2006
  2. ncbi request reprint Prospects for in situ analyses of individual and complexes of DNA, RNA, and protein molecules with padlock and proximity probes
    Ulf Landegren
    Department of Genetics and Pathology, University of Uppsala, S 751 85 Uppsala, Sweden
    Methods Cell Biol 75:787-97. 2004
  3. ncbi request reprint Proximity ligation assays for sensitive and specific protein analyses
    Sigrun M Gustafsdottir
    Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, SE 75185 Uppsala, Sweden
    Anal Biochem 345:2-9. 2005
  4. ncbi request reprint Molecular tools for a molecular medicine: analyzing genes, transcripts and proteins using padlock and proximity probes
    Ulf Landegren
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
    J Mol Recognit 17:194-7. 2004
    ..The procedures permit highly specific solution-phase or localized analyses of large sets of target molecules as required in future molecular analyses...
  5. pmc A dual-tag microarray platform for high-performance nucleic acid and protein analyses
    Olle Ericsson
    Department of Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, SE 75185 Uppsala, Sweden
    Nucleic Acids Res 36:e45. 2008
    ..We provide proof of concept for microarray-based measurement of both mRNA molecules and of proteins, converted to tag DNA sequences by padlock and proximity probe ligation, respectively...
  6. pmc Rapid identification of bio-molecules applied for detection of biosecurity agents using rolling circle amplification
    Jenny Göransson
    tRudbeck Laboratory, Department of Immunology, Genetics and Pathology, SciLifeLab, Uppsala University, Uppsala, Sweden
    PLoS ONE 7:e31068. 2012
    ..The concept is demonstrated by identification of simili biowarfare agents for bacteria (Escherichia coli and Pantoea agglomerans) and spores (Bacillus atrophaeus) released in field...
  7. ncbi request reprint A sense of closeness: protein detection by proximity ligation
    Mats Gullberg
    The Beijer Laboratory, Department of Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    Curr Opin Biotechnol 14:82-6. 2003
    ..Through a ligation reaction a DNA reporter sequence is created, which can be amplified. The procedure thus encodes detected proteins as specific nucleic acid sequences in what may be viewed as a reverse translation reaction...
  8. pmc Cytokine detection by antibody-based proximity ligation
    Mats Gullberg
    The Beijer Laboratory, Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 75185 Uppsala, Sweden
    Proc Natl Acad Sci U S A 101:8420-4. 2004
    ..The technique is applied to measure cytokines in a homogenous test format with femtomolar detection sensitivities in 1-microl samples, and we exemplify its utility in situations when only minute sample amounts are available...
  9. doi request reprint Ligation-based molecular tools for lab-on-a-chip devices
    Jonas Melin
    Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, SE 75185 Uppsala, Sweden
    N Biotechnol 25:42-8. 2008
    ..We discuss these problems and describe a series of molecular tools that may present new opportunities for lab-on-a-chip devices at the point-of-care...
  10. ncbi request reprint Proximity ligation: a specific and versatile tool for the proteomic era
    Ola Söderberg
    University of Uppsala, Department of Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    Genet Eng (N Y) 28:85-93. 2007
    ..In this review we discuss commonly used detection methods and compare these to the recently-developed proximity ligation technique...
  11. ncbi request reprint Homogeneous amplified single-molecule detection: Characterization of key parameters
    Jonas Melin
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, S 751 85 Uppsala, Sweden
    Anal Biochem 368:230-8. 2007
    ..Therefore, the signal/noise ratio is limited by the number of detection sites. By increasing the density of detection sites in the RCP by a factor of 1.9, we show that the optical signal/noise level can be increased from 42 to 75...
  12. pmc High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation
    Karl Johan Leuchowius
    Molecular Medicine, Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Dag Hammarskjölds väg 20, S 751 85 Uppsala, Sweden
    Mol Cell Proteomics 9:178-83. 2010
    ..In addition, inhibitor-induced perturbation of protein-protein interactions of the PDGF signaling pathway could be quantified, further demonstrating the usefulness of the assay in drug discovery...
  13. pmc A single molecule array for digital targeted molecular analyses
    Jenny Göransson
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Nucleic Acids Res 37:e7. 2009
    ..The decoding strategy is generic in that the target can be any biomolecule which has been encoded into a DNA circle via a molecular probing reaction...
  14. ncbi request reprint Digital quantification using amplified single-molecule detection
    Jonas Jarvius
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden
    Nat Methods 3:725-7. 2006
    ..We apply the method for sensitive detection and quantification of the bacterial pathogen Vibrio cholerae...
  15. ncbi request reprint Direct observation of individual endogenous protein complexes in situ by proximity ligation
    Ola Söderberg
    Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, SE 75185 Uppsala, Sweden
    Nat Methods 3:995-1000. 2006
    ..We used this method to show specific regulation of protein-protein interactions between endogenous Myc and Max oncogenic transcription factors in response to interferon-gamma (IFN-gamma) signaling and low-molecular-weight inhibitors...
  16. ncbi request reprint Thermoplastic microfluidic platform for single-molecule detection, cell culture, and actuation
    Jonas Melin
    Beijer Laboratory, Department of Genetics and Pathology, Rudbeck Laboratory, Angstrom Laboratory, University of Uppsala, Sweden
    Anal Chem 77:7122-30. 2005
    ..Biocompatibility of the platform was illustrated by culturing Chinese hamster ovary cells for 7 days in the microfluidic channels...
  17. pmc Parallel gene analysis with allele-specific padlock probes and tag microarrays
    Johan Baner
    The Beijer Laboratory, Department of Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    Nucleic Acids Res 31:e103. 2003
    ..The technique was illustrated by analyzing normal and pathogenic variation within the Wilson disease-related ATP7B gene, both at the level of DNA and RNA, using allele-specific padlock probes...
  18. ncbi request reprint Oligonucleotide ligation assay
    Jonas Jarvius
    Rudbeck Laboratory, Unit of Molecular Medicine, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Methods Mol Biol 212:215-28. 2003
  19. doi request reprint Endothelial cell migration in stable gradients of vascular endothelial growth factor A and fibroblast growth factor 2: effects on chemotaxis and chemokinesis
    Irmeli Barkefors
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    J Biol Chem 283:13905-12. 2008
    ..Our findings suggest that chemotactic growth factor gradients may instruct endothelial cells to shift toward a nonmigratory phenotype when approaching the growth factor source...
  20. ncbi request reprint Protein detection using proximity-dependent DNA ligation assays
    Simon Fredriksson
    The Beijer Laboratory, Department of Genetics and Pathology, Rudbeck Laboratory, SE 75185 Uppsala, Sweden
    Nat Biotechnol 20:473-7. 2002
    ..This proximity ligation assay detects zeptomole (40 x 10(-21) mol) amounts of the cytokine platelet-derived growth factor (PDGF) without washes or separations, and the mechanism can be generalized to other forms of protein analysis...