Anders Isaksson

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. pmc Quantification of normal cell fraction and copy number neutral LOH in clinical lung cancer samples using SNP array data
    Hanna Göransson
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    PLoS ONE 4:e6057. 2009
  2. pmc Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays
    Johan Staaf
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    Genome Biol 9:R136. 2008
  3. ncbi request reprint STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines
    Mårten Fryknäs
    Department of Genetics and Pathology, Uppsala University, Sweden
    Int J Cancer 120:189-95. 2007
  4. doi request reprint Characterization of the cytotoxic properties of the benzimidazole fungicides, benomyl and carbendazim, in human tumour cell lines and primary cultures of patient tumour cells
    Daniel Laryea
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Anticancer Drugs 21:33-42. 2010
  5. doi request reprint Characterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients
    Daniel Laryea
    Division of Clinical Pharmacology, Department of Medical Sciences, University Hospital, 751 85, Uppsala, Sweden
    Invest New Drugs 27:402-11. 2009
  6. ncbi request reprint Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients
    Malin Wickström
    Department of Medical Sciences, Division of Clinical Pharmacology, Entrance 61, 4th Floor Uppsala University Hospital, SE 75185 Uppsala, Sweden
    Biochem Pharmacol 73:25-33. 2007
  7. doi request reprint Mantle cell lymphoma displays a homogenous methylation profile: a comparative analysis with chronic lymphocytic leukemia
    Anna Margrét Halldórsdóttir
    Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden
    Am J Hematol 87:361-7. 2012
  8. ncbi request reprint Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model
    Mårten Fryknäs
    Department of Genetics and Pathology, Uppsala University, S 751 85 Uppsala, Sweden
    J Biomol Screen 11:457-68. 2006
  9. pmc Improved variance estimation of classification performance via reduction of bias caused by small sample size
    Ulrika Wickenberg-Bolin
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    BMC Bioinformatics 7:127. 2006
  10. pmc Loss-of-heterozygosity on chromosome 19q in early-stage serous ovarian cancer is associated with recurrent disease
    Ingiridur Skirnisdottir
    Department of Women s and Children s Health, Uppsala University, SE 75185 Uppsala, Sweden
    BMC Cancer 12:407. 2012

Collaborators

Detail Information

Publications30

  1. pmc Quantification of normal cell fraction and copy number neutral LOH in clinical lung cancer samples using SNP array data
    Hanna Göransson
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    PLoS ONE 4:e6057. 2009
    ..Since tumor tissue invariably contains genetically normal stromal cells, this may lead to a failure to detect aberrations in the tumor cells...
  2. pmc Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays
    Johan Staaf
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    Genome Biol 9:R136. 2008
    ....
  3. ncbi request reprint STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines
    Mårten Fryknäs
    Department of Genetics and Pathology, Uppsala University, Sweden
    Int J Cancer 120:189-95. 2007
    ..These results show that resistance to doxorubicin and radiation is associated with increased STAT1 signaling and can be modulated by fludarabine. The data support further development of therapies combining fludarabine and radiation...
  4. doi request reprint Characterization of the cytotoxic properties of the benzimidazole fungicides, benomyl and carbendazim, in human tumour cell lines and primary cultures of patient tumour cells
    Daniel Laryea
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Anticancer Drugs 21:33-42. 2010
    ..In conclusion, benomyl and carbendazim show interesting and diverse cytotoxic mechanisms of action and seem suitable as lead compounds for the development of new anticancer drugs...
  5. doi request reprint Characterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients
    Daniel Laryea
    Division of Clinical Pharmacology, Department of Medical Sciences, University Hospital, 751 85, Uppsala, Sweden
    Invest New Drugs 27:402-11. 2009
    ..A number of genes were identified as associated with cryptolepine activity. In conclusion, cryptolepine shows interesting in vitro cytotoxic properties and its further evaluation as an anti-cancer drug seems warranted...
  6. ncbi request reprint Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients
    Malin Wickström
    Department of Medical Sciences, Division of Clinical Pharmacology, Entrance 61, 4th Floor Uppsala University Hospital, SE 75185 Uppsala, Sweden
    Biochem Pharmacol 73:25-33. 2007
    ..05), which may indicate some tumor selectivity. These results together with large clinical experience and relatively mild side effects encourage clinical studies of disulfiram as an anti-cancer agent...
  7. doi request reprint Mantle cell lymphoma displays a homogenous methylation profile: a comparative analysis with chronic lymphocytic leukemia
    Anna Margrét Halldórsdóttir
    Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden
    Am J Hematol 87:361-7. 2012
    ..Compared to CLL, however, marked differences were discovered such as the preferential methylation of homeobox genes in MCL...
  8. ncbi request reprint Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model
    Mårten Fryknäs
    Department of Genetics and Pathology, Uppsala University, S 751 85 Uppsala, Sweden
    J Biomol Screen 11:457-68. 2006
    ..This molecular network may provide a basis for further exploitation of novel candidate targets for the treatment of squamous cell carcinoma...
  9. pmc Improved variance estimation of classification performance via reduction of bias caused by small sample size
    Ulrika Wickenberg-Bolin
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    BMC Bioinformatics 7:127. 2006
    ..Here we explore such biases and develop a refined algorithm called Repeated Independent Design and Test (RIDT)...
  10. pmc Loss-of-heterozygosity on chromosome 19q in early-stage serous ovarian cancer is associated with recurrent disease
    Ingiridur Skirnisdottir
    Department of Women s and Children s Health, Uppsala University, SE 75185 Uppsala, Sweden
    BMC Cancer 12:407. 2012
    ..The aim of this study was to investigate if there are specific genomic aberrations that may explain recurrence and clinical outcome...
  11. pmc Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia
    Rebeqa Gunnarsson
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Haematologica 96:1161-9. 2011
    ..Moreover, comparison of genomic profiles from sequential patients' samples allows detection of clonal evolution...
  12. pmc Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells
    Lili Milani
    Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Nucleic Acids Res 35:e34. 2007
    ..The screening process allowed us to zoom in from 160 candidate genes to eight genes that may contain functional rSNPs in their promoter regions...
  13. doi request reprint Improving Bayesian credibility intervals for classifier error rates using maximum entropy empirical priors
    Mats G Gustafsson
    Uppsala University, Department of Medical Sciences, Academic Hospital, 751 85 Uppsala, Sweden
    Artif Intell Med 49:93-104. 2010
    ..Therefore, the aim of the study reported here was to study a maximum entropy (ME) based approach to improved prior knowledge and Bayesian CIs, demonstrating its relevance for biomedical research and clinical practice...
  14. doi request reprint Gene copy number aberrations are associated with survival in histologic subgroups of non-small cell lung cancer
    Patrick Micke
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    J Thorac Oncol 6:1833-40. 2011
    ..To maximize the chance to identify clinically relevant events, we applied a strategy involving two prognostically extreme patient groups...
  15. pmc Allele-specific copy number analysis of tumor samples with aneuploidy and tumor heterogeneity
    Markus Rasmussen
    Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, SE 751 85 Uppsala, Sweden
    Genome Biol 12:R108. 2011
    ..Analysis of cancer samples indicates that TAPS is well suited to investigate samples with aneuploidy and tumor heterogeneity, which is commonly found in many types of solid tumors...
  16. doi request reprint Synergistic interactions between camptothecin and EGFR or RAC1 inhibitors and between imatinib and Notch signaling or RAC1 inhibitors in glioblastoma cell lines
    Linda Sooman
    Rudbeck Laboratory, Department of Radiation, Oncology and Radiation Science, Section of Oncology, Uppsala University, Dag Hammarskjölds väg 20, Uppsala, Sweden
    Cancer Chemother Pharmacol 72:329-40. 2013
    ....
  17. doi request reprint Next generation RNA-sequencing in prognostic subsets of chronic lymphocytic leukemia
    Larry Mansouri
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Am J Hematol 87:737-40. 2012
    ....
  18. pmc High-density screening reveals a different spectrum of genomic aberrations in chronic lymphocytic leukemia patients with 'stereotyped' IGHV3-21 and IGHV4-34 B-cell receptors
    Millaray Marincevic
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
    Haematologica 95:1519-25. 2010
    ....
  19. doi request reprint High-resolution genomic screening in mantle cell lymphoma--specific changes correlate with genomic complexity, the proliferation signature and survival
    Anna M Halldorsdottir
    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Genes Chromosomes Cancer 50:113-21. 2011
    ..01). In summary, this high-resolution genomic analysis identified novel aberrations and revealed that several CNAs correlated with genomic complexity, the proliferation status and survival...
  20. doi request reprint CD99 is a novel prognostic stromal marker in non-small cell lung cancer
    Karolina Edlund
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Int J Cancer 131:2264-73. 2012
    ..The results support the concept that stromal properties have an important impact on tumour progression...
  21. ncbi request reprint Molecular markers for discrimination of benign and malignant follicular thyroid tumors
    Mårten Fryknäs
    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Tumour Biol 27:211-20. 2006
    ..To identify molecular markers useful for the diagnostic discrimination of benign and malignant follicular thyroid tumors...
  22. ncbi request reprint Screening of an annotated compound library for drug activity in a resistant myeloma cell line
    Linda Rickardson
    Department of Medical Sciences, Division of Clinical Pharmacology, Uppsala University, 751 85, Uppsala, Sweden
    Cancer Chemother Pharmacol 58:749-58. 2006
    ....
  23. doi request reprint Extensive expression of craniofacial related homeobox genes in canine mammary sarcomas
    Helena Wensman
    Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, P O Box 7011, 750 07, Uppsala, Sweden
    Breast Cancer Res Treat 118:333-43. 2009
    ..These findings suggest that the development of mammary sarcomas specifically involves triggering of a set of homeobox genes related to neural crest and craniofacial bone development...
  24. doi request reprint The transcriptome of the adenovirus infected cell
    Hongxing Zhao
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden
    Virology 424:115-28. 2012
    ..However, efforts from host cell to block the cell cycle progression and activate an antiviral response were also observed...
  25. pmc Revealing cell cycle control by combining model-based detection of periodic expression with novel cis-regulatory descriptors
    Claes R Andersson
    The Linnaeus Centre for Bioinformatics, Uppsala University and Swedish University of Agricultural Sciences, Uppsala, Sweden
    BMC Syst Biol 1:45. 2007
    ....
  26. pmc Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors
    Millaray Marincevic
    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Haematologica 95:2072-9. 2010
    ..Subset #4 patients appear to share biological and clinical features, e.g. young age at diagnosis and indolent disease, whereas little is known about subset #16 at a clinical level...
  27. pmc Characterization of the RNA content of chromatin
    Tanmoy Mondal
    Department of Genetics and Pathology, Uppsala University, Uppsala S 75185, Sweden
    Genome Res 20:899-907. 2010
    ..Our data suggest that ncRNA is an integral component of chromatin and that it may regulate various biological functions through fine-tuning of the chromatin architecture...
  28. doi request reprint Differential genome-wide array-based methylation profiles in prognostic subsets of chronic lymphocytic leukemia
    Meena Kanduri
    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Blood 115:296-305. 2010
    ..Taken together, our data for the first time reveal differences in global methylation profiles between prognostic subsets of CLL, which may unfold epigenetic silencing mechanisms involved in CLL pathogenesis...
  29. pmc Bayesian detection of periodic mRNA time profiles without use of training examples
    Claes R Andersson
    The Linnaeus Centre for Bioinformatics, BMC, Uppsala University, Box 598, S 751 24 Uppsala, Sweden
    BMC Bioinformatics 7:63. 2006
    ..Previously proposed detector designs require access to labelled training examples and do not allow systematic incorporation of diffuse prior knowledge available about the period time...
  30. doi request reprint Prostasomal DNA characterization and transfer into human sperm
    Göran K Ronquist
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Mol Reprod Dev 78:467-76. 2011
    ..Fluorescence microscopy of slices in the center of 14 optical slides of the sperm head displayed an even fluorescence rather than a halo-like one, indicating DNA-uptake rather than just binding along the sperm head membrane...