Fardin Hosseinpour

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. ncbi request reprint Porcine microsomal vitamin D(3) 25-hydroxylase (CYP2D25). Catalytic properties, tissue distribution, and comparison with human CYP2D6
    F Hosseinpour
    Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, Box 578, S 751 23 Uppsala, Sweden
    J Biol Chem 275:34650-5. 2000
  2. ncbi request reprint Kidney microsomal 25- and 1alpha-hydroxylase in vitamin D metabolism: catalytic properties, molecular cloning, cellular localization and expression during development
    Fardin Hosseinpour
    Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, Box 578, S 751 23, Uppsala, Sweden
    Biochim Biophys Acta 1580:133-44. 2002
  3. ncbi request reprint Phenobarbital suppresses vitamin D3 25-hydroxylase expression: a potential new mechanism for drug-induced osteomalacia
    Fardin Hosseinpour
    Department of Pharmaceutical Biosciences, Division of Biochemistry, University of Uppsala, Box 578, S 751 23 Uppsala, Sweden
    Biochem Biophys Res Commun 357:603-7. 2007
  4. ncbi request reprint Metabolism of 25-hydroxyvitamin D3 by microsomal and mitochondrial vitamin D3 25-hydroxylases (CYP2D25 and CYP27A1): a novel reaction by CYP27A1
    Zufan Araya
    Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, Box 578, Husargatan 3, S 751 23 Uppsala, Sweden
    Biochim Biophys Acta 1632:40-7. 2003
  5. ncbi request reprint 25-Hydroxylation of vitamin D3 in primary cultures of pig hepatocytes: evidence for a role of both CYP2D25 and CYP27A1
    Fardin Hosseinpour
    Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, Box 578, SE 751 23 Uppsala, Sweden
    Biochem Biophys Res Commun 303:877-83. 2003
  6. pmc Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver
    Fardin Hosseinpour
    Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States
    FEBS Lett 581:4937-42. 2007

Collaborators

  • Zufan Araya
  • Kjell Wikvall
  • Karl Bodin

Detail Information

Publications6

  1. ncbi request reprint Porcine microsomal vitamin D(3) 25-hydroxylase (CYP2D25). Catalytic properties, tissue distribution, and comparison with human CYP2D6
    F Hosseinpour
    Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, Box 578, S 751 23 Uppsala, Sweden
    J Biol Chem 275:34650-5. 2000
    ..Experiments with human liver microsomes and recombinantly expressed CYP2D6 strongly indicate that the microsomal 25-hydroxylation of vitamin D(3) in human liver is catalyzed by an enzyme different from CYP2D6...
  2. ncbi request reprint Kidney microsomal 25- and 1alpha-hydroxylase in vitamin D metabolism: catalytic properties, molecular cloning, cellular localization and expression during development
    Fardin Hosseinpour
    Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, Box 578, S 751 23, Uppsala, Sweden
    Biochim Biophys Acta 1580:133-44. 2002
    ..These findings indicate a tissue-specific developmental regulation of CYP2D25. The results from the current and previous studies on renal vitamin D hydroxylations imply that CYP2D25 has a biological role in kidney...
  3. ncbi request reprint Phenobarbital suppresses vitamin D3 25-hydroxylase expression: a potential new mechanism for drug-induced osteomalacia
    Fardin Hosseinpour
    Department of Pharmaceutical Biosciences, Division of Biochemistry, University of Uppsala, Box 578, S 751 23 Uppsala, Sweden
    Biochem Biophys Res Commun 357:603-7. 2007
    ..A downregulation of 25-hydroxylation by phenobarbital may explain, at least in part, the increased risk of osteomalacia, bone loss, and fractures in long-term phenobarbital therapy...
  4. ncbi request reprint Metabolism of 25-hydroxyvitamin D3 by microsomal and mitochondrial vitamin D3 25-hydroxylases (CYP2D25 and CYP27A1): a novel reaction by CYP27A1
    Zufan Araya
    Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, Box 578, Husargatan 3, S 751 23 Uppsala, Sweden
    Biochim Biophys Acta 1632:40-7. 2003
    ..It can be concluded that both CYP27A1 and CYP2D25 are able to carry out multiple hydroxylations of 25-hydroxyvitamin D(3)...
  5. ncbi request reprint 25-Hydroxylation of vitamin D3 in primary cultures of pig hepatocytes: evidence for a role of both CYP2D25 and CYP27A1
    Fardin Hosseinpour
    Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, Box 578, SE 751 23 Uppsala, Sweden
    Biochem Biophys Res Commun 303:877-83. 2003
    ..The results implicate that both CYP2D25 and CYP27A1 contribute to the 25-hydroxylation in hepatocytes and are important in the bioactivation of vitamin D(3)...
  6. pmc Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver
    Fardin Hosseinpour
    Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States
    FEBS Lett 581:4937-42. 2007
    ..CAR directly bound to the PH domain. Thus, ECT2 may comprise a part of the PB response signal regulating the intracellular trafficking of CAR...