Lars Holmberg

Summary

Affiliation: Uppsala University Hospital
Country: Sweden

Publications

  1. ncbi The role of the primary-care physician in oncology care. Primary healthcare and specialist cancer services
    Lars Holmberg
    Regional Oncologic Centre, Uppsala, Sweden
    Lancet Oncol 6:121-2. 2005
  2. ncbi HABITS (hormonal replacement therapy after breast cancer--is it safe?), a randomised comparison: trial stopped
    L Holmberg
    Regional Oncologic Centre, University Hospital, SE 751 85 Uppsala, Sweden
    Lancet 363:453-5. 2004
  3. pmc Radical prostatectomy versus watchful waiting in localized prostate cancer: the Scandinavian prostate cancer group-4 randomized trial
    Anna Bill-Axelson
    Department of Urology, University Hospital, Uppsala, Sweden
    J Natl Cancer Inst 100:1144-54. 2008
  4. doi Radical prostatectomy versus watchful waiting in early prostate cancer
    Anna Bill-Axelson
    Department of Urology, University Hospital, Uppsala, Sweden
    N Engl J Med 364:1708-17. 2011
  5. doi Long-term quality-of-life outcomes after radical prostatectomy or watchful waiting: the Scandinavian Prostate Cancer Group-4 randomised trial
    Eva Johansson
    Department of Surgical Sciences, University Hospital of Uppsala, Uppsala, Sweden
    Lancet Oncol 12:891-9. 2011
  6. doi Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis, and tissue microarray validation
    Johan Botling
    Departments of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Clin Cancer Res 19:194-204. 2013
  7. doi Social differences in breast cancer survival in relation to patient management within a National Health Care System (Sweden)
    Sonja Eaker
    Department of Surgery, Uppsala University, Uppsala, Sweden
    Int J Cancer 124:180-7. 2009
  8. ncbi Long-term distress after radical prostatectomy versus watchful waiting in prostate cancer: a longitudinal study from the Scandinavian Prostate Cancer Group-4 randomized clinical trial
    Anna Bill-Axelson
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Eur Urol 64:920-8. 2013
  9. pmc Serum levels of selenium and smoking habits at age 50 influence long term prostate cancer risk; a 34 year ULSAM follow-up
    Birgitta Grundmark
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    BMC Cancer 11:431. 2011
  10. doi Time, symptom burden, androgen deprivation, and self-assessed quality of life after radical prostatectomy or watchful waiting: the Randomized Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) clinical trial
    Eva Johansson
    Department of Urology, Uppsala University Hospital, Uppsala, Sweden
    Eur Urol 55:422-30. 2009

Detail Information

Publications69

  1. ncbi The role of the primary-care physician in oncology care. Primary healthcare and specialist cancer services
    Lars Holmberg
    Regional Oncologic Centre, Uppsala, Sweden
    Lancet Oncol 6:121-2. 2005
  2. ncbi HABITS (hormonal replacement therapy after breast cancer--is it safe?), a randomised comparison: trial stopped
    L Holmberg
    Regional Oncologic Centre, University Hospital, SE 751 85 Uppsala, Sweden
    Lancet 363:453-5. 2004
    ..We decided that these findings indicated an unacceptable risk for women exposed to HRT in the HABITS trial, and the trial was terminated on Dec 17, 2003...
  3. pmc Radical prostatectomy versus watchful waiting in localized prostate cancer: the Scandinavian prostate cancer group-4 randomized trial
    Anna Bill-Axelson
    Department of Urology, University Hospital, Uppsala, Sweden
    J Natl Cancer Inst 100:1144-54. 2008
    ..In 2005, we reported that radical prostatectomy improved prostate cancer survival compared with watchful waiting after a median of 8.2 years of follow-up. We now report results after 3 more years of follow-up...
  4. doi Radical prostatectomy versus watchful waiting in early prostate cancer
    Anna Bill-Axelson
    Department of Urology, University Hospital, Uppsala, Sweden
    N Engl J Med 364:1708-17. 2011
    ..In 2008, we reported that radical prostatectomy, as compared with watchful waiting, reduces the rate of death from prostate cancer. After an additional 3 years of follow-up, we now report estimated 15-year results...
  5. doi Long-term quality-of-life outcomes after radical prostatectomy or watchful waiting: the Scandinavian Prostate Cancer Group-4 randomised trial
    Eva Johansson
    Department of Surgical Sciences, University Hospital of Uppsala, Uppsala, Sweden
    Lancet Oncol 12:891-9. 2011
    ..We report results for quality of life for men in the Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) after a median follow-up of more than 12 years...
  6. doi Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis, and tissue microarray validation
    Johan Botling
    Departments of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Clin Cancer Res 19:194-204. 2013
    ..So far, the value of these multigene signatures in clinical practice is unclear, and the biologic importance of individual genes is difficult to assess, as the published signatures virtually do not overlap...
  7. doi Social differences in breast cancer survival in relation to patient management within a National Health Care System (Sweden)
    Sonja Eaker
    Department of Surgery, Uppsala University, Uppsala, Sweden
    Int J Cancer 124:180-7. 2009
    ....
  8. ncbi Long-term distress after radical prostatectomy versus watchful waiting in prostate cancer: a longitudinal study from the Scandinavian Prostate Cancer Group-4 randomized clinical trial
    Anna Bill-Axelson
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Eur Urol 64:920-8. 2013
    ..Yet, overcoming patient selection forces is a formidable challenge for observational studies comparing treatment groups...
  9. pmc Serum levels of selenium and smoking habits at age 50 influence long term prostate cancer risk; a 34 year ULSAM follow-up
    Birgitta Grundmark
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    BMC Cancer 11:431. 2011
    ..We investigated the relation between s-Se, smoking and non-screening detected PrCa and explored if polymorphisms in two DNA repair genes: OGG1 and MnSOD, influenced any effect of s-Se...
  10. doi Time, symptom burden, androgen deprivation, and self-assessed quality of life after radical prostatectomy or watchful waiting: the Randomized Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) clinical trial
    Eva Johansson
    Department of Urology, Uppsala University Hospital, Uppsala, Sweden
    Eur Urol 55:422-30. 2009
    ..Quality-of-life outcomes are important in the choice of treatment strategy for men with localized prostate cancer...
  11. doi Cyclin B is an immunohistochemical proliferation marker which can predict for breast cancer death in low-risk node negative breast cancer
    Anthoula Koliadi
    Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden
    Acta Oncol 49:816-20. 2010
    ..Cyclin B is a proliferative marker easily assessed by immunohistochemistry. We wanted to examine cyclin B as a prognostic factor in low-risk breast cancer patients...
  12. ncbi Borderline ovarian tumors in Sweden 1960-2005: trends in incidence and age at diagnosis compared to ovarian cancer
    Ingiridur Skirnisdottir
    Department of Women s and Children s Health, Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden
    Int J Cancer 123:1897-901. 2008
    ....
  13. doi Increased risk of recurrence after hormone replacement therapy in breast cancer survivors
    Lars Holmberg
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    J Natl Cancer Inst 100:475-82. 2008
    ..We present results after extended follow-up...
  14. doi Gene copy number aberrations are associated with survival in histologic subgroups of non-small cell lung cancer
    Patrick Micke
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    J Thorac Oncol 6:1833-40. 2011
    ..To maximize the chance to identify clinically relevant events, we applied a strategy involving two prognostically extreme patient groups...
  15. pmc Differences in management of older women influence breast cancer survival: results from a population-based database in Sweden
    Sonja Eaker
    Regional Oncologic Centre ROC, University Hospital, SE 751 85 Uppsala, Sweden
    PLoS Med 3:e25. 2006
    ..We sought to investigate whether differences in the management of older women with breast cancer are associated with survival...
  16. doi Season of diagnosis and prognosis in breast and prostate cancer
    Lars Holmberg
    Regional Oncologic Center and Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Cancer Causes Control 20:663-70. 2009
    ..Patients with breast or prostate cancer diagnosed during the summer season have been observed to have better survival. The extent to which this is due to biological and/or health care system related factors is unclear...
  17. doi Distribution of coronary artery stenosis after radiation for breast cancer
    Greger Nilsson
    Uppsala University, University Hospital, SE 751 85 Uppsala, Sweden
    J Clin Oncol 30:380-6. 2012
    ..To study distribution of coronary artery stenosis among patients with breast cancer (BC) and to assess correlation between radiotherapy (RT) and location of stenosis...
  18. ncbi Prognostic markers under watchful waiting and radical prostatectomy
    Lars Holmberg
    Regional Oncologic Center, University Hospital, Uppsala, Sweden
    Hematol Oncol Clin North Am 20:845-55. 2006
    ..Because overall prognostic information obtained by these parameters or by tumor stage was not provided in our publication, we now present these data in the two study arms separately...
  19. ncbi Non-genital tract metastases to the ovaries presented as ovarian tumors in Sweden 1990-2003: occurrence, origin and survival compared to ovarian cancer
    Ingiridur Skirnisdottir
    Department of Women s and Children s Health, Obstetrics and Gynecology, Akademiska University Hospital, Uppsala, Sweden
    Gynecol Oncol 105:166-71. 2007
    ..Origin of metastases and time of detection in relation to surgery were recorded. Age at diagnosis, survival for ovarian metastasis compared to ovarian cancer and prognostic factors were evaluated...
  20. doi Dietary patterns and prostate cancer risk: report from the population based ULSAM cohort study of swedish men
    Erika Ax
    a Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
    Nutr Cancer 66:77-87. 2014
    ..In this study, a LCHP diet was associated with lower prostate cancer incidence. Relations emerged in adequate reporters, underscoring the importance of high-quality dietary data. ..
  21. ncbi Radical prostatectomy versus watchful waiting in early prostate cancer
    Anna Bill-Axelson
    Department of Urology, University Hospital, Uppsala, Sweden
    N Engl J Med 352:1977-84. 2005
    ..In 2002, we reported the initial results of a trial comparing radical prostatectomy with watchful waiting in the management of early prostate cancer. After three more years of follow-up, we report estimated 10-year results...
  22. doi CD99 is a novel prognostic stromal marker in non-small cell lung cancer
    Karolina Edlund
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Int J Cancer 131:2264-73. 2012
    ..The results support the concept that stromal properties have an important impact on tumour progression...
  23. pmc The metabolic syndrome and the risk of prostate cancer under competing risks of death from other causes
    Birgitta Grundmark
    Regional Oncologic Centre, Uppsala University Hospital, Uppsala, Sweden
    Cancer Epidemiol Biomarkers Prev 19:2088-96. 2010
    ..Using the National Cholesterol Education Program Adult Treatment panel III (NCEP) and International Diabetes Federation (IDF) definitions of the MetS, we investigated such associations taking competing risks of death into consideration...
  24. doi Experiences of randomization: interviews with patients and clinicians in the SPCG-IV trial
    Anna Bill-Axelson
    Department of Urology, Uppsala University Hospital, Uppsala, Sweden
    Scand J Urol Nephrol 42:358-63. 2008
    ..This study investigated patients' and clinicians' experiences of randomization with the aim of facilitating trial participation in the future...
  25. ncbi Regional differences in breast cancer survival despite common guidelines
    Sonja Eaker
    Department of Surgery, Regional Oncologic Centre, University Hospital of Uppsala, SE 751 85 Uppsala, Sweden
    Cancer Epidemiol Biomarkers Prev 14:2914-8. 2005
    ..We therefore examined breast cancer survival in relation to differences in diagnostic activity, tumor characteristics, and treatment in seven Swedish counties within a single health care region...
  26. pmc Reducing the noise in signal detection of adverse drug reactions by standardizing the background: a pilot study on analyses of proportional reporting ratios-by-therapeutic area
    Birgitta Grundmark
    Department of Surgical Sciences, Uppsala University, 75185, Uppsala, Sweden
    Eur J Clin Pharmacol 70:627-35. 2014
    ....
  27. pmc Birth outcome in women with previously treated breast cancer--a population-based cohort study from Sweden
    Kristina Dalberg
    Department of Surgery and the Regional Oncologic Centre, Uppsala University Hospital, Uppsala, Sweden
    PLoS Med 3:e336. 2006
    ..The aim of this study was to assess the risk of adverse birth outcomes in women previously treated for invasive breast cancer compared with the general population of mothers...
  28. pmc Evaluation of prediction models for decision-making: beyond calibration and discrimination
    Lars Holmberg
    Regional Cancer Center Uppsala Örebro, Uppsala University Hospital, Uppsala, Sweden
    PLoS Med 10:e1001491. 2013
    b>Lars Holmberg and Andrew Vickers discuss the importance of ensuring prediction models lead to better decision making in light of new research into breast, endometrial, and ovarian cancer risk by Ruth Pfeiffer and colleagues...
  29. ncbi The biology and natural history of prostate cancer: a short introduction
    Lars Holmberg
    Department of Surgical Sciences, Uppsala University Regional Cancer Center University Hospital, Uppsala, Sweden
    Recent Results Cancer Res 202:1-7. 2014
    ..The understanding of prostate cancer aetiology and natural history has progressed slowly. However, the current situation is positively challenging and opens up possibilities for fruitful research. ..
  30. pmc Survival endpoints in colorectal cancer and the effect of second primary other cancer on disease free survival
    Helgi Birgisson
    Department of Surgical Sciences, Colorectal Surgery, Uppsala University, Uppsala, Sweden
    BMC Cancer 11:438. 2011
    ..The aim of this study was to compare different survival endpoints in patients with primary colorectal cancer (CRC) and to understand the effect of second primary other cancer on disease-free survival (DFS) calculations...
  31. ncbi Reducing cancer drug doses in obese patients: dogma disputed
    Lars Holmberg
    Regional Oncologic Centre, University Hospital, S 751 85 Uppsala, Sweden
    Lancet 366:1056-7. 2005
  32. doi Regional differences in treatment and outcome in non-small cell lung cancer: a population-based study (Sweden)
    Gunnar Myrdal
    Department of Thoracic and Cardiovascular Surgery, Uppsala University Hospital, Uppsala, Sweden
    Lung Cancer 63:16-22. 2009
    ..Despite common guidelines there were marked differences in treatment activity between the counties. Treatment activity was associated with survival. Survival benefits may follow improvement in compliance to guidelines...
  33. doi Cyclin A is a proliferative marker with good prognostic value in node-negative breast cancer
    Cecilia Ahlin
    Department of Oncology, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Cancer Epidemiol Biomarkers Prev 18:2501-6. 2009
    ..Studies suggest that cyclin A is a prognostic marker with satisfying reproducibility. We investigated cyclin A as a prognostic marker in node-negative breast cancer using previously defined cutoff values. Patients and..
  34. ncbi Neoadjuvant cisplatinum based combination chemotherapy in patients with invasive bladder cancer: a combined analysis of two Nordic studies
    Amir Sherif
    Department of Urology, Akademiska University Hospital, SE 751 85 Uppsala, Sweden
    Eur Urol 45:297-303. 2004
    ..We analyzed overall survival in all patients and in prespecified subgroups defined by preoperative T-stage, gender and age...
  35. doi Plasma vitamin D and mortality in older men: a community-based prospective cohort study
    Karl Michaelsson
    Department of Surgical Sciences and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
    Am J Clin Nutr 92:841-8. 2010
    ..Vitamin D status is known to be important for bone health but may also affect the development of several chronic diseases, including cancer and cardiovascular diseases, which are 2 major causes of death...
  36. ncbi Increased incidence of stroke in women with breast cancer
    Greger Nilsson
    Section of Oncology, Department of Oncology, Radiology and Clinical Immunology, University Hospital, SE 751 85 Uppsala, Sweden
    Eur J Cancer 41:423-9. 2005
    ..A statistically significant increase in the risk of stroke was seen among women with a history of breast cancer. Whether this risk is associated with the breast cancer disease per se or related to any treatment requires further study...
  37. ncbi Breast-conserving surgery without radiotherapy
    L Holmberg
    Department of Surgery, University Hospital, Uppsala, Sweden
    Acta Oncol 34:681-3. 1995
    ..4) If the long-term--positive and negative--effects of radiotherapy were better quantified. Until we have new information, postoperative radiotherapy after breast conservation remains the standard...
  38. ncbi Risk factors for subsequent invasive breast cancer and breast cancer death after ductal carcinoma in situ: a population-based case-control study in Sweden
    F Warnberg
    Department of Surgery, University Hospital, S 751 85 Uppsala, Sweden
    Cancer Epidemiol Biomarkers Prev 10:495-9. 2001
    ..The driving forces behind local and generalized disease may differ. Because confounding by indication may influence the effects of different treatments, the results should be interpreted with caution...
  39. pmc Radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke
    G Nilsson
    Department of Oncology, Radiology and Clinical Immunology, University Hospital, Uppsala, Sweden
    Br J Cancer 100:811-6. 2009
    ..Our finding of a target-specific increased risk of stroke and a dose-response relationship for daily fraction dose, indicate that there may be a causal link between RT to the IMC and SCL and risk of stroke...
  40. pmc Defining a high mortality risk group among women with primary breast cancer
    T Norden
    Department of Surgery, University Hospital, Uppsala, Sweden
    Br J Cancer 69:520-4. 1994
    ..Women with no involved nodes and with three or four negative factors had a risk of dying from breast cancer similar to that of node-positive women with fewer than three...
  41. ncbi Five-node biopsy of the axilla: an alternative to axillary dissection of levels I-II in operable breast cancer
    J Ahlgren
    Department of Oncology, University Hospital, Uppsala, S 751 85, Sweden
    Eur J Surg Oncol 28:97-102. 2002
    ..Less invasive ways to establish the axillary nodal status are therefore of interest, especially in women with low risk of nodal metastases...
  42. ncbi Age as a determinant of axillary node involvement in invasive breast cancer
    L Holmberg
    Department of Surgery, University Hospital, Uppsala, Sweden
    Acta Oncol 31:533-8. 1992
    ..The findings indicate that the parallelism between the establishment of metastases in lymph nodes and at distant sites may vary with age. The prognostic value of nodal status may therefore depend on age at diagnosis...
  43. ncbi Pre-operative oestradiol levels - relation to survival in breast cancer
    L Holmberg
    Department of Surgery, University Hospital, Uppsala, MA, S 751 85, Sweden
    Eur J Surg Oncol 27:152-6. 2001
    ..However, few studies have information on plasma levels of hormones pre-operatively...
  44. pmc Failure to detect early breast cancer using in vitro nuclear magnetic resonance spectroscopy of plasma
    L Holmberg
    Department of Surgery, University Hospital, Uppsala, Sweden
    Br J Cancer 68:389-92. 1993
    ..7 Hz). In vitro NMR spectroscopy in our hands was thus not a useful diagnostic tool in patients with early breast cancer...
  45. ncbi Sector resection with and without radiotherapy in early breast cancer. Presentation of two ongoing prospective multicenter studies in Sweden. Uppsala/Orebro Breast Cancer Study Group
    L Holmberg
    Department of Surgery, University Hospital, Uppsala, Sweden
    Acta Oncol 28:927-9. 1989
    ..Overall 5% of the women in the conservatively treated group and 22% of the mastectomized women are still suffering substantial psychosocial disturbance after 13 months...
  46. ncbi Role of surgery in invasive breast cancer
    L Holmberg
    Department of Surgery, University Hospital, Uppsala, Sweden
    Acta Oncol 34:625-8. 1995
    ....
  47. pmc Prognosis in bilateral breast cancer. Effects of time interval between first and second primary tumours
    L Holmberg
    Department of Surgery, University Hospital, Uppsala, Sweden
    Br J Cancer 58:191-4. 1988
    ..The results indicate that the two tumours contribute independently to the patient's excess risk of dying and thus occur as two seemingly biologically unrelated events with respect to the tumour-host relationship and metastatic behaviour...
  48. ncbi Ductal carcinoma in situ of the breast: a new phenotype classification system and its relation to prognosis
    F Warnberg
    Department of Surgery, University Hospital, Uppsala, Sweden
    Breast Cancer Res Treat 73:215-21. 2002
    ....
  49. ncbi Preoperative serum levels of follicle stimulating hormone (FSH) and prognosis in invasive breast cancer
    M Eskelinen
    Regional Oncologic Center and Department of Surgery, University of Uppsala, Uppsala, Sweden
    Eur J Surg Oncol 30:495-500. 2004
    ..We investigated the association between preoperative serum levels of follicle stimulating hormone (FSH) and the prognosis in women with invasive breast cancer...
  50. ncbi Neoadjuvant cisplatin-methotrexate chemotherapy for invasive bladder cancer -- Nordic cystectomy trial 2
    Amir Sherif
    Department of Urology, Akademiska University Hospital, Uppsala, Sweden
    Scand J Urol Nephrol 36:419-25. 2002
    ..The aim of this study was to investigate if solely neoadjuvant chemotherapy could influence survival in patients with advanced urothelial bladder cancer undergoing cystectomy...
  51. ncbi Overexpression of cyclin E protein is associated with specific mutation types in the p53 gene and poor survival in human breast cancer
    Thomas Lindahl
    Department of Oncology and Pathology, Radiumhemmet, Karolinska Hospital and Institute R8 03, S 171 76 Stockholm, Sweden
    Carcinogenesis 25:375-80. 2004
    ..4, 95% confidence interval 1.3-4.5). In summary, our findings demonstrate that overexpression of cyclin E is associated with an aggressive tumor phenotype and specific types of p53 mutations...
  52. ncbi Determinants of cancer patients' utilization of hospital care within two years after diagnosis
    Birgitta B K Johansson
    Department of Oncology, Radiology and Clinical Immunology, the Section of Caring Sciences, Uppsala University, Sweden
    Acta Oncol 43:536-44. 2004
    ..The results suggest that thorough assessment can identify patients at diagnosis with an increased need for follow-up, e.g. intensified home care services...
  53. ncbi SweDCIS: Radiotherapy after sector resection for ductal carcinoma in situ of the breast. Results of a randomised trial in a population offered mammography screening
    Stefan O Emdin
    Department of Surgery, Umea University Hospital, Umea, Sweden
    Acta Oncol 45:536-43. 2006
    ..Women undergoing sector resection for DCIS under conditions of population based screening mammography benefit from postoperative RT to the breast. Seven patients needed RT-treatment to prevent one recurrence...
  54. ncbi Quality of life after radical prostatectomy or watchful waiting
    Gunnar Steineck
    Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
    N Engl J Med 347:790-6. 2002
    ..We evaluated symptoms and self-assessments of quality of life in men with localized prostate cancer who participated in a randomized comparison between radical prostatectomy and watchful waiting...
  55. ncbi The usefulness of a multidisciplinary educational programme after breast cancer surgery: a prospective and comparative study
    IngaLill Koinberg
    Department of Research 3D, Varberg Hospital, S 432 81 Varberg, Sweden
    Eur J Oncol Nurs 10:273-82. 2006
    ..A multidisciplinary educational programme may be an alternative to traditional follow-up by a physician after breast cancer surgery, but more research is needed about the financial benefits and effectiveness of such a programme...
  56. pmc Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts
    Yudi Pawitan
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Breast Cancer Res 7:R953-64. 2005
    ..Breast cancer expression profiling has so far mainly been used to identify women with a poor prognosis as candidates for adjuvant therapy but without demonstrated value for therapy prediction...
  57. ncbi [Registries contribute to better breast cancer care]
    Leif Bergkvist
    Kirurgkliniken och Centrum för klinisk forskning, Centrallasarettet, Vasteras
    Lakartidningen 101:2579-81. 2004
  58. ncbi Prostate-specific antigen levels as a predictor of lethal prostate cancer
    Katja Fall
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, S 171 77 Stockholm, Sweden
    J Natl Cancer Inst 99:526-32. 2007
    ..Rates of long-term survival among patients with untreated localized prostate cancer are high. To avoid unnecessary treatment, tools are needed to identify the small proportion of patients who are destined to develop lethal prostate cancer...
  59. ncbi Colorectal cancer survival in the Nordic countries and the United Kingdom: excess mortality risk analysis of 5 year relative period survival in the period 1999 to 2000
    Gerda Engholm
    Department of Cancer Prevention and Documentation, Danish Cancer Society, Copenhagen, Denmark
    Int J Cancer 121:1115-22. 2007
    ..Use of more detailed age-intervals than conventionally applied in survival studies proved to be important in statistical modelling and is recommended for future studies...
  60. ncbi [Insufficient studies of diagnostic cancer tests. Neither systematic review nor original studies come up to expectations]
    Lars Holmberg
    Regionalt onkologiskt centrum, Akademiska sjukhuset, Uppsala
    Lakartidningen 104:1308-9. 2007
  61. ncbi A randomized trial comparing radical prostatectomy with watchful waiting in early prostate cancer
    Lars Holmberg
    Regional Oncologic Center, University Hospital, Uppsala, Sweden
    N Engl J Med 347:781-9. 2002
    ..Radical prostatectomy is widely used in the treatment of early prostate cancer. The possible survival benefit of this treatment, however, is unclear. We conducted a randomized trial to address this question...
  62. ncbi The impact of organized mammography service screening on breast carcinoma mortality in seven Swedish counties
    Stephen W Duffy
    Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, PO Box 123, Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Cancer 95:458-69. 2002
    ..e., nonattenders) after the initiation of organized screening...
  63. ncbi Breast cancer patients' satisfaction with a spontaneous system of check-up visits to a specialist nurse
    Inga Lill Koinberg
    Oncology Clinic, Varberg Hospital, Varberg, Sweden
    Scand J Caring Sci 16:209-15. 2002
    ..To describe breast cancer patients' satisfaction with a spontaneous system of check-up visits to a specialist nurse...
  64. ncbi [A unique cooperation between trials on hormone replacement therapy following breast cancer]
    Lars Holmberg
    Lakartidningen 100:2317. 2003
  65. doi Active surveillance for early-stage prostate cancer: review of the current literature
    Marc A Dall'Era
    Department of Urology, University of California at San Francisco Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143 1695, USA
    Cancer 112:1650-9. 2008
    ..The best candidates for active surveillance are being defined, as are predictors of active treatment. The psychosocial ramifications of surveillance for prostate cancer can be profound and future needs and unmet goals will be discussed...
  66. ncbi [Quicker reporting to the Cancer Registry is required, according to a new regulation]
    Lotti Barlow
    Epidemiologiskt centrum, Socialstyrelsen, Stockholm
    Lakartidningen 100:3152-4. 2003
  67. ncbi Coffee, tea, and caffeine consumption and breast cancer incidence in a cohort of Swedish women
    Karin B Michels
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Epidemiol 12:21-6. 2002
    ..Prior epidemiologic evidence has not supported an overall association between consumption of caffeinated beverages and risk of breast cancer, but consumption in some studies was low...
  68. doi Absolute risk reductions for local recurrence after postoperative radiotherapy after sector resection for ductal carcinoma in situ of the breast
    Lars Holmberg
    Division of Cancer Studies, Thomas Guy House, 3rd Floor, King s College London, Guy s Campus, London SE1 9RT, United Kingdom
    J Clin Oncol 26:1247-52. 2008
    ..Evaluate the effects of radiotherapy after sector resection for ductal carcinoma in situ of the breast (DCIS) in patient groups as defined by age, size of the lesion, focality, completeness of excision and mode of detection...
  69. ncbi Ductal carcinoma in situ of the breast with different histopathological grades and corresponding new breast tumour events: analysis of loss of heterozygosity
    Johanna Smeds
    Department of Oncology Pathology, Radiumhemmet Cancer Centre Karolinska, Karolinska Institute and Hospital, S 171 76 Stockholm, Sweden
    Acta Oncol 44:41-9. 2005
    ..Also observed was a complete heterogeneity of LOH in the primary DCIS and their corresponding new events, suggesting that these events probably developed from genetically divergent clones...