L Hillered

Summary

Affiliation: Uppsala University Hospital
Country: Sweden

Publications

  1. ncbi request reprint Continuous monitoring of cerebral metabolism in traumatic brain injury: a focus on cerebral microdialysis
    Lars Hillered
    Department of Neuroscience, Uppsala University Hospital, Uppsala, Sweden
    Curr Opin Crit Care 12:112-8. 2006
  2. ncbi request reprint Translational neurochemical research in acute human brain injury: the current status and potential future for cerebral microdialysis
    Lars Hillered
    Division of Neurosurgery, Department of Surgery, The David Geffen UCLA School of Medicine, Los Angeles, California, USA
    J Neurotrauma 22:3-41. 2005
  3. pmc Interstitial glycerol as a marker for membrane phospholipid degradation in the acutely injured human brain
    L Hillered
    Department of Neurosurgery, Uppsala University Hospital, Sweden
    J Neurol Neurosurg Psychiatry 64:486-91. 1998
  4. ncbi request reprint Middle cerebral artery occlusion and reperfusion in primates monitored by microdialysis and sequential positron emission tomography
    P Enblad
    Department of Clinical Neurosciences Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    Stroke 32:1574-80. 2001
  5. ncbi request reprint Intracerebral microdialysis in neurointensive care: the use of urea as an endogenous reference compound
    E Ronne-Engstrom
    Department of Neuroscience, University Hospital, Uppsala, Sweden
    J Neurosurg 94:397-402. 2001
  6. doi request reprint Ibuprofen attenuates the inflammatory response and allows formation of migratory neuroblasts from grafted stem cells after traumatic brain injury
    U Wallenquist
    Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden
    Restor Neurol Neurosci 30:9-19. 2012
  7. ncbi request reprint Free radical scavenger posttreatment improves functional and morphological outcome after fluid percussion injury in the rat
    N Marklund
    Department of Neuroscience and Neurosurgery, University Hospital, Uppsala, Sweden
    J Neurotrauma 18:821-32. 2001
  8. pmc Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate model
    P Frykholm
    Department of Neuroscience, Section of Neurosurgery, Uppsala University Hospital, S-751 85 Uppsala, Sweden
    J Neurol Neurosurg Psychiatry 71:455-61. 2001
  9. ncbi request reprint Changes in microtubule-associated protein 2 and amyloid precursor protein immunoreactivity following traumatic brain injury in rat: influence of MK-801 treatment
    A Lewen
    Department of Neurosurgery, Uppsala University Hospital, Sweden
    Brain Res 719:161-71. 1996
  10. doi request reprint Brain energy metabolism in patients with spontaneous subarachnoid hemorrhage and global cerebral edema
    Maria Zetterling
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    Neurosurgery 66:1102-10. 2010

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Continuous monitoring of cerebral metabolism in traumatic brain injury: a focus on cerebral microdialysis
    Lars Hillered
    Department of Neuroscience, Uppsala University Hospital, Uppsala, Sweden
    Curr Opin Crit Care 12:112-8. 2006
    ..This review highlights recent advances in cerebral microdialysis as a tool for neurochemical monitoring of patients with traumatic brain injury...
  2. ncbi request reprint Translational neurochemical research in acute human brain injury: the current status and potential future for cerebral microdialysis
    Lars Hillered
    Division of Neurosurgery, Department of Surgery, The David Geffen UCLA School of Medicine, Los Angeles, California, USA
    J Neurotrauma 22:3-41. 2005
    ..Methodological issues that appeared critical for the future success of MD as a routine intracerebral sampling method were addressed...
  3. pmc Interstitial glycerol as a marker for membrane phospholipid degradation in the acutely injured human brain
    L Hillered
    Department of Neurosurgery, Uppsala University Hospital, Sweden
    J Neurol Neurosurg Psychiatry 64:486-91. 1998
    ..Brain interstitial glycerol was studied as a potential marker for membrane phospholipid degradation in acute human brain injury...
  4. ncbi request reprint Middle cerebral artery occlusion and reperfusion in primates monitored by microdialysis and sequential positron emission tomography
    P Enblad
    Department of Clinical Neurosciences Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    Stroke 32:1574-80. 2001
    ....
  5. ncbi request reprint Intracerebral microdialysis in neurointensive care: the use of urea as an endogenous reference compound
    E Ronne-Engstrom
    Department of Neuroscience, University Hospital, Uppsala, Sweden
    J Neurosurg 94:397-402. 2001
    ....
  6. doi request reprint Ibuprofen attenuates the inflammatory response and allows formation of migratory neuroblasts from grafted stem cells after traumatic brain injury
    U Wallenquist
    Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden
    Restor Neurol Neurosci 30:9-19. 2012
    ..Neuroinflammation may lead to additional cell death after TBI and we hypothesized that survival of grafted NSPC could be enhanced by anti-inflammatory treatment...
  7. ncbi request reprint Free radical scavenger posttreatment improves functional and morphological outcome after fluid percussion injury in the rat
    N Marklund
    Department of Neuroscience and Neurosurgery, University Hospital, Uppsala, Sweden
    J Neurotrauma 18:821-32. 2001
    ..Our results suggest that nitrone radical scavengers are neuroprotective when administered 30 min after FPI in rats. Differences in pharmacokinetics may account for the observed individual neuroprotective profiles of the two nitrones...
  8. pmc Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate model
    P Frykholm
    Department of Neuroscience, Section of Neurosurgery, Uppsala University Hospital, S-751 85 Uppsala, Sweden
    J Neurol Neurosurg Psychiatry 71:455-61. 2001
    ..Interstitial glycerol in combination with other biochemical markers such as the LP ratio and glutamate may be useful for clinical monitoring of the ischaemic brain, reflecting a sequence of secondary pathophysiological events...
  9. ncbi request reprint Changes in microtubule-associated protein 2 and amyloid precursor protein immunoreactivity following traumatic brain injury in rat: influence of MK-801 treatment
    A Lewen
    Department of Neurosurgery, Uppsala University Hospital, Sweden
    Brain Res 719:161-71. 1996
    ..The cause of this phenomenon is not known but may be related to a delayed neurotoxic action of MK-801 treatment...
  10. doi request reprint Brain energy metabolism in patients with spontaneous subarachnoid hemorrhage and global cerebral edema
    Maria Zetterling
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    Neurosurgery 66:1102-10. 2010
    ..Effects of secondary ischemic events also influence outcome after SAH...
  11. ncbi request reprint Paradoxical increase in neuronal DNA fragmentation after neuroprotective free radical scavenger treatment in experimental traumatic brain injury
    A Lewen
    Department of Neuroscience, Division of Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    J Cereb Blood Flow Metab 21:344-50. 2001
    ..This should be considered in the screening process for future neuroprotective remedies...
  12. ncbi request reprint Effect of 21-aminosteroid on extracellular energy-related metabolites and amino acids after compression injury of rat spinal cord
    M Farooque
    Laboratory of Neuropathology, University Hospital, Uppsala, Sweden
    Exp Brain Res 113:1-4. 1997
    ..However, the mean extracellular level of glutamate was lower with both methylprednisolone and 21-aminosteroid after injury, although the difference was not statistically significant between treated and untreated rats...
  13. ncbi request reprint Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose, and lactate metabolism
    Thomas C Glenn
    UCLA Cerebral Blood Flow Laboratory, California, USA
    J Cereb Blood Flow Metab 23:1239-50. 2003
    ..Future studies are needed to determine to what degree nonglycolytic energy production from alternative fuels such as lactate occurs after TBI and whether alternative fuel administration is a viable therapy for TBI patients...
  14. ncbi request reprint Changes in mACh, NMDA and GABA(A) receptor binding after lateral fluid-percussion injury: in vitro autoradiography of rat brain frozen sections
    S Sihver
    Department of Neuroscience, Unit of Pharmacology, Faculty of Medicine, University of Uppsala, Uppsala, Sweden
    J Neurochem 78:417-23. 2001
    ..The finding of a decreased BP demonstrates the involvement of these receptor systems in the development of cellular dysfunction, which is widespread and not limited to the site of lateral FPI...
  15. ncbi request reprint alpha-Phenyl-tert-N-butyl nitrone (PBN) improves functional and morphological outcome after cortical contusion injury in the rat
    N Marklund
    Department of Neurosurgery, Uppsala University Hospital, Sweden
    Acta Neurochir (Wien) 143:73-81. 2001
    ..05). Our results support the involvement of ROS in the injury process contributing to the tissue loss and cognitive disturbance after TBI. The potential clinical utility of PBN will have to be assessed using a post-injury dosing regime...
  16. ncbi request reprint Extracellular amino acid levels measured with intracerebral microdialysis in the model of posttraumatic epilepsy induced by intracortical iron injection
    E Ronne Engstrom
    Department of Neurosurgery, Uppsala University Hospital, S 751 85, Uppsala, Sweden
    Epilepsy Res 43:135-44. 2001
    ..The observed amino acid changes in epileptic animals may be involved in the development of seizures in this model of posttraumatic epilepsy...
  17. doi request reprint Temporal patterns of interstitial pyruvate and amino acids after subarachnoid haemorrhage are related to the level of consciousness--a clinical microdialysis study
    Maria Zetterling
    Department of Neuroscience Neurosurgery, Uppsala University Hospital, 75185 Uppsala, Sweden
    Acta Neurochir (Wien) 151:771-80; discussion 780. 2009
    ....
  18. doi request reprint Selective antegrade cerebral perfusion at two different temperatures compared to hypothermic circulatory arrest--an experimental study in the pig with microdialysis
    Ove Jonsson
    Department of Surgical Sciences, Thoracic Surgery, Uppsala University Hospital, Uppsala University, Uppsala, Sweden
    Interact Cardiovasc Thorac Surg 8:647-53. 2009
    ..05). This study supports the use of SACP over arrest. It also suggests that cerebral metabolism and cellular membrane integrity may be better preserved with SACP at 20 degrees C compared to 28 degrees C...
  19. doi request reprint Grafted neural progenitors migrate and form neurons after experimental traumatic brain injury
    U Wallenquist
    Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, Uppsala, Sweden
    Restor Neurol Neurosci 27:323-34. 2009
    ..However, efforts to transplant neural progenitors in animal models of brain injury typically result in high cell mortality and poor neuronal differentiation...
  20. ncbi request reprint Cognitive and histopathological outcome after weight-drop brain injury in the rat: influence of systemic administration of monoclonal antibodies to ICAM-1
    J Isaksson
    Department of Genetics and Pathology, Uppsala University Hospital, Sweden
    Acta Neuropathol 102:246-56. 2001
    ..Treatment with the anti-ICAM-1 antibody 1A29 did not significantly change the recorded functional or histopathological measures of outcome...
  21. ncbi request reprint Effects of the nitrone radical scavengers PBN and S-PBN on in vivo trapping of reactive oxygen species after traumatic brain injury in rats
    N Marklund
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Sweden
    J Cereb Blood Flow Metab 21:1259-67. 2001
    ..This finding supports an important role for ROS production at the blood-endothelial interface in TBI...
  22. pmc Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice
    N Marklund
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroscience 163:540-51. 2009
    ....
  23. ncbi request reprint Expression of ICAM-1 and CD11b after experimental spinal cord injury in rats
    J Isaksson
    Research Group on Neuropathology, Department of Genetics and Pathology, Uppsala University Hospital, Sweden
    J Neurotrauma 16:165-73. 1999
    ....
  24. ncbi request reprint Early cerebral hyperglycolysis after subarachnoid haemorrhage correlates with favourable outcome
    K G Cesarini
    Department of Neuroscience, Section of Neurosurgery, Uppsala University, Uppsala, Sweden
    Acta Neurochir (Wien) 144:1121-31. 2002
    ..Intracerebral microdialysis (MD) was applied in patients with severe subarachnoid haemorrhage treated in a neurosurgical intensive care unit in order to explore their cerebral energy metabolism...
  25. ncbi request reprint Monitoring of reactive oxygen species production after traumatic brain injury in rats with microdialysis and the 4-hydroxybenzoic acid trapping method
    N Marklund
    Department of Neuroscience and Neurosurgery, Clinical Chemistry at Uppsala University Hospital, Sweden
    J Neurotrauma 18:1217-27. 2001
    ..In addition, high cortical concentrations of 4-HBA and salicylate were found. It is concluded that microdialysis with 4-HBA as a trapping agent appears to be a useful method for ROS detection in the rat with a potential clinical utility...
  26. doi request reprint The nitrone free radical scavenger NXY-059 is neuroprotective when administered after traumatic brain injury in the rat
    Fredrik Clausen
    Section for Neurosurgery, Department of Neuroscience, Uppsala University, Uppsala, Sweden
    J Neurotrauma 25:1449-57. 2008
    ..01). The results show that post-injury treatment with NXY-059 significantly attenuated the loss of injured brain tissue and improved cognitive outcome, suggesting a major role for ROS in the pathophysiology of TBI...
  27. doi request reprint Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury
    Niklas Marklund
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Gothenburg, Sweden
    J Neurosurg 110:1227-37. 2009
    ....
  28. doi request reprint Increased cerebral uptake of [18F]fluoro-deoxyglucose but not [1-14C]glucose early following traumatic brain injury in rats
    Niklas Marklund
    Department of Neuroscience, Uppsala University CSO, Imanet, Uppsala, Sweden
    J Neurotrauma 26:1281-93. 2009
    ..These results should be considered when interpreting results obtained using FDG for the estimation of lCMR(Glc) early following experimental TBI...
  29. doi request reprint Relationship between intracranial hemodynamics and microdialysis markers of energy metabolism and glutamate-glutamine turnover in patients with subarachnoid hemorrhage. Clinical article
    Carolina Samuelsson
    Department of Neuroscience, Uppsala University Hospital, Uppsala, Sweden
    J Neurosurg 111:910-5. 2009
    ..The aim of this study was to explore the relationship between hemodynamics (intracranial and systemic) and brain tissue energy metabolism, and between hemodynamics and glutamate (Glt)-glutamine (Gln) cycle activity...
  30. doi request reprint Microdialysis patterns in subarachnoid hemorrhage patients with focus on ischemic events and brain interstitial glutamine levels
    Carolina Samuelsson
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    Acta Neurochir (Wien) 151:437-46; discussion 446. 2009
    ....
  31. doi request reprint Vimentin and GFAP responses in astrocytes after contusion trauma to the murine brain
    Sara Ekmark-Lewén
    Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
    Restor Neurol Neurosci 28:311-21. 2010
    ..We also wanted to study the vimentin response with immunohistochemistry and vimentin mRNA RT-PCR analysis in severe cortical contusion injury produced by the controlled cortical impact in the mouse...
  32. ncbi request reprint Cerebral glutamine and glutamate levels in relation to compromised energy metabolism: a microdialysis study in subarachnoid hemorrhage patients
    Carolina Samuelsson
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    J Cereb Blood Flow Metab 27:1309-17. 2007
    ....
  33. ncbi request reprint Energy metabolic changes in the early post-injury period following traumatic brain injury in rats
    Niklas Marklund
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, SE 75185 Uppsala, Sweden
    Neurochem Res 31:1085-93. 2006
    ..05). The energy-requiring secondary injury cascades that occur early post-injury do not challenge the brain tissue to the extent of ATP depletion and may provide a window of opportunity for therapeutic intervention...
  34. ncbi request reprint Effect of traumatic brain injury and nitrone radical scavengers on relative changes in regional cerebral blood flow and glucose uptake in rats
    Niklas Marklund
    Department of Neuroscience Neurosurgery, Uppsala University, Sweden
    J Neurotrauma 19:1139-53. 2002
    ..Thus, the early improvement in rCBF and glucose metabolism correlates with and may partly mediate the improved functional and morphological outcome after TBI in nitrone-treated rats...
  35. ncbi request reprint Oxygen free radical-dependent activation of extracellular signal-regulated kinase mediates apoptosis-like cell death after traumatic brain injury
    Fredrik Clausen
    Department of Neuroscience and Neurosurgery, Uppsala University Hospital, S 75 185 Uppsala, Sweden
    J Neurotrauma 21:1168-82. 2004
    ..Clinical studies are warranted to evaluate the concept of MEK inhibition in head-injured patients...
  36. ncbi request reprint Cerebral interstitial levels of glutamate and glutamine after intravenous administration of nutritional amino acids in neurointensive care patients
    Elisabeth Ronne Engstrom
    Department of Neurosurgery, Uppsala University Hospital, 751 85 Uppsala, Sweden
    Neurosci Lett 384:7-10. 2005
    ..However, since BBB function was not quantified in our study, further evaluation of this issue is warranted...
  37. ncbi request reprint Correlation of hippocampal morphological changes and morris water maze performance after cortical contusion injury in rats
    Fredrik Clausen
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    Neurosurgery 57:154-63; discussion 154-63. 2005
    ..We also analyzed the influence of pretreatment with the nitrone radical scavenger alpha-phenyl-N-tert-butyl-nitrone (PBN)...
  38. ncbi request reprint Relationship between cerebral blood flow and oxygen metabolism, and extracellular glucose and lactate concentrations during middle cerebral artery occlusion and reperfusion: a microdialysis and positron emission tomography study in nonhuman primates
    Peter Frykholm
    Department of Clinical Neurosciences Neurosurgery, Uppsala University Hospital, Sweden
    J Neurosurg 102:1076-84. 2005
    ..The authors related extracellular concentrations of glucose and lactate to regional cerebral blood flow (rCBF) and cerebral metabolic rate of oxygen (CMRO2) in a model of ischemia...
  39. ncbi request reprint Temporally resolved differential proteomic analysis of human ventricular CSF for monitoring traumatic brain injury biomarker candidates
    Jörg Hanrieder
    Department of Physical and Analytical Chemistry, Analytical Chemistry, Uppsala University, Uppsala, Sweden
    J Neurosci Methods 177:469-78. 2009
    ..This methodology appears to be a promising tool for studying candidate biomarkers of neurovascular and traumatic brain injuries in the neurointensive care setting...
  40. doi request reprint Neutralization of interleukin-1beta modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice
    Fredrik Clausen
    Department of Neuroscience, Section for Neurosurgery, Uppsala University, Uppsala, Sweden
    Eur J Neurosci 30:385-96. 2009
    ....
  41. ncbi request reprint Intracranial pressure changes during fluid percussion, controlled cortical impact and weight drop injury in rats
    F Clausen
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    Acta Neurochir (Wien) 147:775-80; discussion 780. 2005
    ..Severe controlled cortical impact (CCI) and severe weight drop injury (WDI) were studied for comparison...
  42. ncbi request reprint T lymphocyte trafficking: a novel target for neuroprotection in traumatic brain injury
    Fredrik Clausen
    Department of Neuroscience, Section of Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    J Neurotrauma 24:1295-307. 2007
    ..Our data suggest that targeting T lymphocyte trafficking to the injured brain at the microvascular level is a novel concept of neuroprotection in TBI and warrants further exploration...
  43. ncbi request reprint Genetically modified bone morphogenetic protein signalling alters traumatic brain injury-induced gene expression responses in the adult mouse
    Charlotte Israelsson
    Department of Neuroscience, Developmental Neuroscience, Biomedical Center, Uppsala University, Uppsala, Sweden
    J Neurosci Res 84:47-57. 2006
    ..Altogether, the data suggest that BMP signalling is dispensable in adult cortical neurons but that augmented BMP signalling affects molecular changes associated with neuronal lesions...
  44. doi request reprint Appearance of Cxcl10-expressing cell clusters is common for traumatic brain injury and neurodegenerative disorders
    Charlotte Israelsson
    Department of Neuroscience, Developmental Neuroscience, Biomedical Center, Uppsala University, PO Box 593, SE 751 24 Uppsala, Sweden
    Eur J Neurosci 31:852-63. 2010
    ..It is concluded that the Cxcl10(+) cells appear in the inflamed central nervous system and may represent a novel population of cells that it may be possible to target pharmacologically in a broad range of neurodegenerative conditions...
  45. ncbi request reprint Quantitative determination of cerebrospinal fluid bilirubin on a high throughput chemistry analyzer
    Degmo Said Ahmed
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
    Clin Lab 55:283-8. 2009
    ..The aim of the study was to develop a quantitative diazo reagent based analysis of cerebrospinal fluid bilirubin as a replacement for spectrophotometric scanning...
  46. ncbi request reprint Microdialysis for neurochemical monitoring of the human brain
    Lars Hillered
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    Scand Cardiovasc J 37:13-7. 2003
  47. ncbi request reprint Cyclooxygenase-2, prostaglandin synthases, and prostaglandin H2 metabolism in traumatic brain injury in the rat
    Tina Kunz
    Department of Pharmaceutical Biosciences, Uppsala Biomedical Center, Uppsala University, Uppsala, Sweden
    J Neurotrauma 19:1051-64. 2002
    ....
  48. doi request reprint Distinct cellular patterns of upregulated chemokine expression supporting a prominent inflammatory role in traumatic brain injury
    Charlotte Israelsson
    Department of Neuroscience, Developmental Neuroscience, Biomedical Center, Uppsala University, Uppsala, Sweden
    J Neurotrauma 25:959-74. 2008
    ..In conclusion, our study shows that following TBI, secondary injury chiefly involves inflammatory processes and chemokine signaling, which comprise putative targets for pharmaceutical neuroprotection...
  49. doi request reprint Nonischemic energy metabolic crisis in acute brain injury
    Lars Hillered
    Crit Care Med 36:2952-3. 2008
  50. ncbi request reprint Effects of the selective cyclooxygenase-2 inhibitor rofecoxib on cell death following traumatic brain injury in the rat
    Tina Kunz
    Department of Pharmaceutical Biosciences, Uppsala Biomedical Centre, Uppsala University, SE 751 24 Uppsala, Sweden
    Restor Neurol Neurosci 24:55-63. 2006
    ..The objective was to investigate whether the selective COX-2 inhibitor rofecoxib (10 mg/kg twice daily) reduces neuronal cell death after FPI in rats, since rofecoxib has been shown to be neuroprotective in other models of CNS injury...
  51. ncbi request reprint Microdialysis measurements demonstrate a shift to nonoxidative glucose metabolism in rat pancreatic islets transplanted beneath the renal capsule
    Per Ola Carlsson
    Department of Medical Cell Biology, Uppsala University, Sweden
    Surgery 132:487-94. 2002
    ..We aimed to use microdialysis to assess, for the first time, the internal milieu of pancreatic islet grafts...
  52. ncbi request reprint Assessment of the effects of the cyclooxygenase-2 inhibitor rofecoxib on visuospatial learning and hippocampal cell death following kainate-induced seizures in the rat
    Tina Kunz
    Department of Pharmaceutical Biosciences, Uppsala Biomedical Centre, Uppsala University, SE 751 24 Uppsala, Sweden
    Brain Res Cogn Brain Res 25:826-32. 2005
    ....