Research Topics
Species | L HilleredSummaryAffiliation: Uppsala University Hospital Country: Sweden Publications
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Publications
Continuous monitoring of cerebral metabolism in traumatic brain injury: a focus on cerebral microdialysisLars Hillered
Department of Neuroscience, Uppsala University Hospital, Uppsala, Sweden
Curr Opin Crit Care 12:112-8. 2006..This review highlights recent advances in cerebral microdialysis as a tool for neurochemical monitoring of patients with traumatic brain injury...- Translational neurochemical research in acute human brain injury: the current status and potential future for cerebral microdialysisLars Hillered
Division of Neurosurgery, Department of Surgery, The David Geffen UCLA School of Medicine, Los Angeles, California, USA
J Neurotrauma 22:3-41. 2005..Methodological issues that appeared critical for the future success of MD as a routine intracerebral sampling method were addressed... 
Interstitial glycerol as a marker for membrane phospholipid degradation in the acutely injured human brainL Hillered
Department of Neurosurgery, Uppsala University Hospital, Sweden
J Neurol Neurosurg Psychiatry 64:486-91. 1998..Brain interstitial glycerol was studied as a potential marker for membrane phospholipid degradation in acute human brain injury...- Middle cerebral artery occlusion and reperfusion in primates monitored by microdialysis and sequential positron emission tomographyP Enblad
Department of Clinical Neurosciences Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
Stroke 32:1574-80. 2001.... - Intracerebral microdialysis in neurointensive care: the use of urea as an endogenous reference compoundE Ronne-Engstrom
Department of Neuroscience, University Hospital, Uppsala, Sweden
J Neurosurg 94:397-402. 2001.... 
Ibuprofen attenuates the inflammatory response and allows formation of migratory neuroblasts from grafted stem cells after traumatic brain injuryU Wallenquist
Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden
Restor Neurol Neurosci 30:9-19. 2012..Neuroinflammation may lead to additional cell death after TBI and we hypothesized that survival of grafted NSPC could be enhanced by anti-inflammatory treatment...- Free radical scavenger posttreatment improves functional and morphological outcome after fluid percussion injury in the ratN Marklund
Department of Neuroscience and Neurosurgery, University Hospital, Uppsala, Sweden
J Neurotrauma 18:821-32. 2001..Our results suggest that nitrone radical scavengers are neuroprotective when administered 30 min after FPI in rats. Differences in pharmacokinetics may account for the observed individual neuroprotective profiles of the two nitrones... - Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate modelP Frykholm
Department of Neuroscience, Section of Neurosurgery, Uppsala University Hospital, S-751 85 Uppsala, Sweden
J Neurol Neurosurg Psychiatry 71:455-61. 2001..Interstitial glycerol in combination with other biochemical markers such as the LP ratio and glutamate may be useful for clinical monitoring of the ischaemic brain, reflecting a sequence of secondary pathophysiological events... - Changes in microtubule-associated protein 2 and amyloid precursor protein immunoreactivity following traumatic brain injury in rat: influence of MK-801 treatmentA Lewen
Department of Neurosurgery, Uppsala University Hospital, Sweden
Brain Res 719:161-71. 1996..The cause of this phenomenon is not known but may be related to a delayed neurotoxic action of MK-801 treatment... - Brain energy metabolism in patients with spontaneous subarachnoid hemorrhage and global cerebral edemaMaria Zetterling
Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
Neurosurgery 66:1102-10. 2010..Effects of secondary ischemic events also influence outcome after SAH... - Paradoxical increase in neuronal DNA fragmentation after neuroprotective free radical scavenger treatment in experimental traumatic brain injuryA Lewen
Department of Neuroscience, Division of Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
J Cereb Blood Flow Metab 21:344-50. 2001..This should be considered in the screening process for future neuroprotective remedies... - Effect of 21-aminosteroid on extracellular energy-related metabolites and amino acids after compression injury of rat spinal cordM Farooque
Laboratory of Neuropathology, University Hospital, Uppsala, Sweden
Exp Brain Res 113:1-4. 1997..However, the mean extracellular level of glutamate was lower with both methylprednisolone and 21-aminosteroid after injury, although the difference was not statistically significant between treated and untreated rats... - Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose, and lactate metabolismThomas C Glenn
UCLA Cerebral Blood Flow Laboratory, California, USA
J Cereb Blood Flow Metab 23:1239-50. 2003..Future studies are needed to determine to what degree nonglycolytic energy production from alternative fuels such as lactate occurs after TBI and whether alternative fuel administration is a viable therapy for TBI patients... - Changes in mACh, NMDA and GABA(A) receptor binding after lateral fluid-percussion injury: in vitro autoradiography of rat brain frozen sectionsS Sihver
Department of Neuroscience, Unit of Pharmacology, Faculty of Medicine, University of Uppsala, Uppsala, Sweden
J Neurochem 78:417-23. 2001..The finding of a decreased BP demonstrates the involvement of these receptor systems in the development of cellular dysfunction, which is widespread and not limited to the site of lateral FPI... - alpha-Phenyl-tert-N-butyl nitrone (PBN) improves functional and morphological outcome after cortical contusion injury in the ratN Marklund
Department of Neurosurgery, Uppsala University Hospital, Sweden
Acta Neurochir (Wien) 143:73-81. 2001..05). Our results support the involvement of ROS in the injury process contributing to the tissue loss and cognitive disturbance after TBI. The potential clinical utility of PBN will have to be assessed using a post-injury dosing regime... - Extracellular amino acid levels measured with intracerebral microdialysis in the model of posttraumatic epilepsy induced by intracortical iron injectionE Ronne Engstrom
Department of Neurosurgery, Uppsala University Hospital, S 751 85, Uppsala, Sweden
Epilepsy Res 43:135-44. 2001..The observed amino acid changes in epileptic animals may be involved in the development of seizures in this model of posttraumatic epilepsy... - Temporal patterns of interstitial pyruvate and amino acids after subarachnoid haemorrhage are related to the level of consciousness--a clinical microdialysis studyMaria Zetterling
Department of Neuroscience Neurosurgery, Uppsala University Hospital, 75185 Uppsala, Sweden
Acta Neurochir (Wien) 151:771-80; discussion 780. 2009.... - Selective antegrade cerebral perfusion at two different temperatures compared to hypothermic circulatory arrest--an experimental study in the pig with microdialysisOve Jonsson
Department of Surgical Sciences, Thoracic Surgery, Uppsala University Hospital, Uppsala University, Uppsala, Sweden
Interact Cardiovasc Thorac Surg 8:647-53. 2009..05). This study supports the use of SACP over arrest. It also suggests that cerebral metabolism and cellular membrane integrity may be better preserved with SACP at 20 degrees C compared to 28 degrees C... - Grafted neural progenitors migrate and form neurons after experimental traumatic brain injuryU Wallenquist
Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, Uppsala, Sweden
Restor Neurol Neurosci 27:323-34. 2009..However, efforts to transplant neural progenitors in animal models of brain injury typically result in high cell mortality and poor neuronal differentiation... - Cognitive and histopathological outcome after weight-drop brain injury in the rat: influence of systemic administration of monoclonal antibodies to ICAM-1J Isaksson
Department of Genetics and Pathology, Uppsala University Hospital, Sweden
Acta Neuropathol 102:246-56. 2001..Treatment with the anti-ICAM-1 antibody 1A29 did not significantly change the recorded functional or histopathological measures of outcome... - Effects of the nitrone radical scavengers PBN and S-PBN on in vivo trapping of reactive oxygen species after traumatic brain injury in ratsN Marklund
Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Sweden
J Cereb Blood Flow Metab 21:1259-67. 2001..This finding supports an important role for ROS production at the blood-endothelial interface in TBI... - Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient miceN Marklund
Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroscience 163:540-51. 2009.... - Expression of ICAM-1 and CD11b after experimental spinal cord injury in ratsJ Isaksson
Research Group on Neuropathology, Department of Genetics and Pathology, Uppsala University Hospital, Sweden
J Neurotrauma 16:165-73. 1999.... - Early cerebral hyperglycolysis after subarachnoid haemorrhage correlates with favourable outcomeK G Cesarini
Department of Neuroscience, Section of Neurosurgery, Uppsala University, Uppsala, Sweden
Acta Neurochir (Wien) 144:1121-31. 2002..Such hyperglycolysis may be elicited in patients with recovery potential to cope with an extreme metabolic demand set in motion by a brain insult to restore brain cell homeostasis and integrity... - Monitoring of reactive oxygen species production after traumatic brain injury in rats with microdialysis and the 4-hydroxybenzoic acid trapping methodN Marklund
Department of Neuroscience and Neurosurgery, Clinical Chemistry at Uppsala University Hospital, Sweden
J Neurotrauma 18:1217-27. 2001..In addition, high cortical concentrations of 4-HBA and salicylate were found. It is concluded that microdialysis with 4-HBA as a trapping agent appears to be a useful method for ROS detection in the rat with a potential clinical utility... - The nitrone free radical scavenger NXY-059 is neuroprotective when administered after traumatic brain injury in the ratFredrik Clausen
Section for Neurosurgery, Department of Neuroscience, Uppsala University, Uppsala, Sweden
J Neurotrauma 25:1449-57. 2008..01). The results show that post-injury treatment with NXY-059 significantly attenuated the loss of injured brain tissue and improved cognitive outcome, suggesting a major role for ROS in the pathophysiology of TBI... - Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injuryNiklas Marklund
Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Gothenburg, Sweden
J Neurosurg 110:1227-37. 2009.... - Increased cerebral uptake of [18F]fluoro-deoxyglucose but not [1-14C]glucose early following traumatic brain injury in ratsNiklas Marklund
Department of Neuroscience, Uppsala University CSO, Imanet, Uppsala, Sweden
J Neurotrauma 26:1281-93. 2009..These results should be considered when interpreting results obtained using FDG for the estimation of lCMR(Glc) early following experimental TBI... - Relationship between intracranial hemodynamics and microdialysis markers of energy metabolism and glutamate-glutamine turnover in patients with subarachnoid hemorrhage. Clinical articleCarolina Samuelsson
Department of Neuroscience, Uppsala University Hospital, Uppsala, Sweden
J Neurosurg 111:910-5. 2009..The aim of this study was to explore the relationship between hemodynamics (intracranial and systemic) and brain tissue energy metabolism, and between hemodynamics and glutamate (Glt)-glutamine (Gln) cycle activity... - Microdialysis patterns in subarachnoid hemorrhage patients with focus on ischemic events and brain interstitial glutamine levelsCarolina Samuelsson
Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
Acta Neurochir (Wien) 151:437-46; discussion 446. 2009.... - Vimentin and GFAP responses in astrocytes after contusion trauma to the murine brainSara Ekmark-Lewén
Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
Restor Neurol Neurosci 28:311-21. 2010..We also wanted to study the vimentin response with immunohistochemistry and vimentin mRNA RT-PCR analysis in severe cortical contusion injury produced by the controlled cortical impact in the mouse... - Cerebral glutamine and glutamate levels in relation to compromised energy metabolism: a microdialysis study in subarachnoid hemorrhage patientsCarolina Samuelsson
Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
J Cereb Blood Flow Metab 27:1309-17. 2007.... - Energy metabolic changes in the early post-injury period following traumatic brain injury in ratsNiklas Marklund
Department of Neuroscience, Neurosurgery, Uppsala University Hospital, SE 75185 Uppsala, Sweden
Neurochem Res 31:1085-93. 2006..05). The energy-requiring secondary injury cascades that occur early post-injury do not challenge the brain tissue to the extent of ATP depletion and may provide a window of opportunity for therapeutic intervention... - Effect of traumatic brain injury and nitrone radical scavengers on relative changes in regional cerebral blood flow and glucose uptake in ratsNiklas Marklund
Department of Neuroscience Neurosurgery, Uppsala University, Sweden
J Neurotrauma 19:1139-53. 2002..Thus, the early improvement in rCBF and glucose metabolism correlates with and may partly mediate the improved functional and morphological outcome after TBI in nitrone-treated rats... - Oxygen free radical-dependent activation of extracellular signal-regulated kinase mediates apoptosis-like cell death after traumatic brain injuryFredrik Clausen
Department of Neuroscience and Neurosurgery, Uppsala University Hospital, S 75 185 Uppsala, Sweden
J Neurotrauma 21:1168-82. 2004..Clinical studies are warranted to evaluate the concept of MEK inhibition in head-injured patients... - Cerebral interstitial levels of glutamate and glutamine after intravenous administration of nutritional amino acids in neurointensive care patientsElisabeth Ronne Engstrom
Department of Neurosurgery, Uppsala University Hospital, 751 85 Uppsala, Sweden
Neurosci Lett 384:7-10. 2005..However, since BBB function was not quantified in our study, further evaluation of this issue is warranted... - Correlation of hippocampal morphological changes and morris water maze performance after cortical contusion injury in ratsFredrik Clausen
Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
Neurosurgery 57:154-63; discussion 154-63. 2005..We also analyzed the influence of pretreatment with the nitrone radical scavenger alpha-phenyl-N-tert-butyl-nitrone (PBN)... - Relationship between cerebral blood flow and oxygen metabolism, and extracellular glucose and lactate concentrations during middle cerebral artery occlusion and reperfusion: a microdialysis and positron emission tomography study in nonhuman primatesPeter Frykholm
Department of Clinical Neurosciences/Neurosurgery, Uppsala University Hospital, Sweden
J Neurosurg 102:1076-84. 2005..In situations with elevated lactate levels, glucose may help to discriminate between partial and severe ischemia... - Temporally resolved differential proteomic analysis of human ventricular CSF for monitoring traumatic brain injury biomarker candidatesJörg Hanrieder
Department of Physical and Analytical Chemistry, Analytical Chemistry, Uppsala University, Uppsala, Sweden
J Neurosci Methods 177:469-78. 2009..This methodology appears to be a promising tool for studying candidate biomarkers of neurovascular and traumatic brain injuries in the neurointensive care setting... - Neutralization of interleukin-1beta modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in miceFredrik Clausen
Department of Neuroscience, Section for Neurosurgery, Uppsala University, Uppsala, Sweden
Eur J Neurosci 30:385-96. 2009.... - Intracranial pressure changes during fluid percussion, controlled cortical impact and weight drop injury in ratsF Clausen
Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
Acta Neurochir (Wien) 147:775-80; discussion 780. 2005..Severe controlled cortical impact (CCI) and severe weight drop injury (WDI) were studied for comparison... - T lymphocyte trafficking: a novel target for neuroprotection in traumatic brain injuryFredrik Clausen
Department of Neuroscience, Section of Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
J Neurotrauma 24:1295-307. 2007..Our data suggest that targeting T lymphocyte trafficking to the injured brain at the microvascular level is a novel concept of neuroprotection in TBI and warrants further exploration... - Genetically modified bone morphogenetic protein signalling alters traumatic brain injury-induced gene expression responses in the adult mouseCharlotte Israelsson
Department of Neuroscience, Developmental Neuroscience, Biomedical Center, Uppsala University, Uppsala, Sweden
J Neurosci Res 84:47-57. 2006..Altogether, the data suggest that BMP signalling is dispensable in adult cortical neurons but that augmented BMP signalling affects molecular changes associated with neuronal lesions... - Appearance of Cxcl10-expressing cell clusters is common for traumatic brain injury and neurodegenerative disordersCharlotte Israelsson
Department of Neuroscience, Developmental Neuroscience, Biomedical Center, Uppsala University, PO Box 593, SE 751 24 Uppsala, Sweden
Eur J Neurosci 31:852-63. 2010..It is concluded that the Cxcl10(+) cells appear in the inflamed central nervous system and may represent a novel population of cells that it may be possible to target pharmacologically in a broad range of neurodegenerative conditions... - Quantitative determination of cerebrospinal fluid bilirubin on a high throughput chemistry analyzerDegmo Said Ahmed
Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
Clin Lab 55:283-8. 2009..The aim of the study was to develop a quantitative diazo reagent based analysis of cerebrospinal fluid bilirubin as a replacement for spectrophotometric scanning... - Microdialysis for neurochemical monitoring of the human brainLars Hillered
Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
Scand Cardiovasc J 37:13-7. 2003 - Cyclooxygenase-2, prostaglandin synthases, and prostaglandin H2 metabolism in traumatic brain injury in the ratTina Kunz
Department of Pharmaceutical Biosciences, Uppsala Biomedical Center, Uppsala University, Uppsala, Sweden
J Neurotrauma 19:1051-64. 2002.... - Distinct cellular patterns of upregulated chemokine expression supporting a prominent inflammatory role in traumatic brain injuryCharlotte Israelsson
Department of Neuroscience, Developmental Neuroscience, Biomedical Center, Uppsala University, Uppsala, Sweden
J Neurotrauma 25:959-74. 2008..In conclusion, our study shows that following TBI, secondary injury chiefly involves inflammatory processes and chemokine signaling, which comprise putative targets for pharmaceutical neuroprotection... - Nonischemic energy metabolic crisis in acute brain injuryLars Hillered
Crit Care Med 36:2952-3. 2008 - Effects of the selective cyclooxygenase-2 inhibitor rofecoxib on cell death following traumatic brain injury in the ratTina Kunz
Department of Pharmaceutical Biosciences, Uppsala Biomedical Centre, Uppsala University, SE-751 24 Uppsala, Sweden
Restor Neurol Neurosci 24:55-63. 2006..06), and appeared unchanged at 72 h. CONCLUSIONS: Rofecoxib lacked significant protective effect on early neuronal cell death in the FPI model of traumatic brain injury... - Microdialysis measurements demonstrate a shift to nonoxidative glucose metabolism in rat pancreatic islets transplanted beneath the renal capsulePer-Ola Carlsson
Department of Medical Cell Biology, Uppsala University, Sweden
Surgery 132:487-94. 2002..Moreover, the high lactate/pyruvate ratio suggests that islet grafts have an increased anaerobic glucose metabolism... - Assessment of the effects of the cyclooxygenase-2 inhibitor rofecoxib on visuospatial learning and hippocampal cell death following kainate-induced seizures in the ratTina Kunz
Department of Pharmaceutical Biosciences, Uppsala Biomedical Centre, Uppsala University, SE 751 24 Uppsala, Sweden
Brain Res Cogn Brain Res 25:826-32. 2005....