Bo Hellman

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. ncbi request reprint Glucose induces glucagon release pulses antisynchronous with insulin and sensitive to purinoceptor inhibition
    Eva Grapengiesser
    Department of Medical Cell Biology, Biomedicum Box 571, SE 75123 Uppsala, Sweden
    Endocrinology 147:3472-7. 2006
  2. ncbi request reprint Activation of alpha adrenergic and muscarinic receptors modifies early glucose suppression of cytoplasmic Ca(2+) in pancreatic β-cells
    Bo Hellman
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden Electronic address
    Biochem Biophys Res Commun 445:629-32. 2014
  3. doi request reprint Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon
    Bo Hellman
    Department of Medical Cell Biology, University of Uppsala, SE 75123 Uppsala, Sweden
    Biochem Biophys Res Commun 417:1219-23. 2012
  4. ncbi request reprint [Insulin oscillations--clinically important rhythm. Antidiabetics should increase the pulsative component of the insulin release]
    Bo Hellman
    Uppsala universitet, Uppsala
    Lakartidningen 104:2236-9. 2007
  5. doi request reprint Glucose generates coincident insulin and somatostatin pulses and antisynchronous glucagon pulses from human pancreatic islets
    Bo Hellman
    Department of Medical Cell Biology, University of Uppsala, Uppsala, Sweden
    Endocrinology 150:5334-40. 2009
  6. pmc Pulsatility of insulin release--a clinically important phenomenon
    Bo Hellman
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Ups J Med Sci 114:193-205. 2009
  7. ncbi request reprint Effects of external ATP on Ca(2+) signalling in endothelial cells isolated from mouse islets
    Bo Hellman
    Department of Medical Cell Biology, University of Uppsala, Biomedicum Box 571, Uppsala, 751 23, Sweden
    Endocrine 32:33-40. 2007
  8. doi request reprint The neurotransmitter ATP triggers Ca2+ responses promoting coordination of pancreatic islet oscillations
    Erik Gylfe
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Pancreas 41:258-63. 2012
  9. ncbi request reprint Pancreatic beta-cells communicate via intermittent release of ATP
    Bo Hellman
    Department of Medical Cell Biology, Biomedicum, University of Uppsala, SE 751 23 Uppsala, Sweden
    Am J Physiol Endocrinol Metab 286:E759-65. 2004
  10. ncbi request reprint Stretch activation of Ca2+ transients in pancreatic beta cells by mobilization of intracellular stores
    Eva Grapengiesser
    Department of Medical Cell Biology, Uppsala University, Biomedicum, Uppsala, Sweden
    Pancreas 26:82-6. 2003

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Glucose induces glucagon release pulses antisynchronous with insulin and sensitive to purinoceptor inhibition
    Eva Grapengiesser
    Department of Medical Cell Biology, Biomedicum Box 571, SE 75123 Uppsala, Sweden
    Endocrinology 147:3472-7. 2006
    ..However, in contrast to what was observed for insulin, MRS 2179 lowered average glucagon release to the level of the oscillatory nadirs...
  2. ncbi request reprint Activation of alpha adrenergic and muscarinic receptors modifies early glucose suppression of cytoplasmic Ca(2+) in pancreatic β-cells
    Bo Hellman
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden Electronic address
    Biochem Biophys Res Commun 445:629-32. 2014
    ..It is concluded that the period of initial decrease of [Ca(2+)]i regulates the subsequent β-cell response to glucose...
  3. doi request reprint Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon
    Bo Hellman
    Department of Medical Cell Biology, University of Uppsala, SE 75123 Uppsala, Sweden
    Biochem Biophys Res Commun 417:1219-23. 2012
    ..The data indicate that the mouse serves as an appropriate animal model for studying the temporal relation between the islet hormones controlling glucose production in the liver...
  4. ncbi request reprint [Insulin oscillations--clinically important rhythm. Antidiabetics should increase the pulsative component of the insulin release]
    Bo Hellman
    Uppsala universitet, Uppsala
    Lakartidningen 104:2236-9. 2007
  5. doi request reprint Glucose generates coincident insulin and somatostatin pulses and antisynchronous glucagon pulses from human pancreatic islets
    Bo Hellman
    Department of Medical Cell Biology, University of Uppsala, Uppsala, Sweden
    Endocrinology 150:5334-40. 2009
    ..The resulting greater than 20-fold variations of the insulin to glucagon ratio might be essential for minute-to-minute regulation of the hepatic glucose production...
  6. pmc Pulsatility of insulin release--a clinically important phenomenon
    Bo Hellman
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Ups J Med Sci 114:193-205. 2009
    ..Current protocols for pulsatile intravenous infusion therapy (PIVIT) should be modified to mimic the anti-synchrony between insulin and glucagon normally seen in the portal blood...
  7. ncbi request reprint Effects of external ATP on Ca(2+) signalling in endothelial cells isolated from mouse islets
    Bo Hellman
    Department of Medical Cell Biology, University of Uppsala, Biomedicum Box 571, Uppsala, 751 23, Sweden
    Endocrine 32:33-40. 2007
    ..It is suggested that the endothelial cells have a tonic inhibitory action on beta-cell P2 purinoceptors resulting in impaired synchronization of the insulin release pulses...
  8. doi request reprint The neurotransmitter ATP triggers Ca2+ responses promoting coordination of pancreatic islet oscillations
    Erik Gylfe
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Pancreas 41:258-63. 2012
    ....
  9. ncbi request reprint Pancreatic beta-cells communicate via intermittent release of ATP
    Bo Hellman
    Department of Medical Cell Biology, Biomedicum, University of Uppsala, SE 751 23 Uppsala, Sweden
    Am J Physiol Endocrinol Metab 286:E759-65. 2004
    ..It is proposed that beta-cells both receive a neural ATP signal with coordinating effects on their Ca2+ oscillations and propagate this message to adjacent cells via intermittent release of ATP combined with gap junction coupling...
  10. ncbi request reprint Stretch activation of Ca2+ transients in pancreatic beta cells by mobilization of intracellular stores
    Eva Grapengiesser
    Department of Medical Cell Biology, Uppsala University, Biomedicum, Uppsala, Sweden
    Pancreas 26:82-6. 2003
    ....
  11. ncbi request reprint Pulses of external ATP aid to the synchronization of pancreatic beta-cells by generating premature Ca(2+) oscillations
    Eva Grapengiesser
    Department of Medical Cell Biology, Uppsala University, Biomedicum, SE 75123 Uppsala, Sweden
    Biochem Pharmacol 68:667-74. 2004
    ..The results support the idea that purinergic activation of phospholipase A(2) has a co-ordinating effect on the beta-cell rhythmicity by triggering premature [Ca(2+)](i) oscillations mediated by closure of ATP-sensitive K(+) channels...
  12. ncbi request reprint Insulin-secreting INS-1 cells generate a novel type of poorly synchronized Ca2+ transients
    Gernot Dorff
    Department of Medical Cell Biology, Uppsala University, Biomedicum, Box 571, SE 751 23 Uppsala, Sweden
    Biochem Biophys Res Commun 293:842-6. 2002
    ..If appearing in native beta-cells, the type of [Ca2+]i transients now observed may interfere with the coordination of the beta-cell rhythmicity evoked by NANC neurons...
  13. ncbi request reprint Inhibition of purinoceptors amplifies glucose-stimulated insulin release with removal of its pulsatility
    Albert Salehi
    Institute of Physiological Sciences, University of Lund, Lund, Sweden
    Diabetes 54:2126-31. 2005
    ....
  14. ncbi request reprint Carbon monoxide stimulates insulin release and propagates Ca2+ signals between pancreatic beta-cells
    Ingmar Lundquist
    Department of Pharmacology, Institute of Physiological Sciences, University of Lund, BMC F13, S 221 84 Lund, Sweden
    Am J Physiol Endocrinol Metab 285:E1055-63. 2003
    ..In addition to serving as a positive modulator of glucose-stimulated insulin release, CO acts as a messenger propagating Ca2+ signals with coordinating effects on the beta-cell rhythmicity...
  15. ncbi request reprint Phospholipase A2 is important for glucose induction of rhythmic Ca2+ signals in pancreatic beta cells
    Gerd Larsson-Nyrén
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, University of Umeå University, Umea, Sweden
    Pancreas 35:173-9. 2007
    ....
  16. ncbi request reprint Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon
    Albert Salehi
    Department of Clinical Science, CRC UMAS, University of Lund, SE 20502 Malmo, Sweden
    Regul Pept 144:43-9. 2007
    ..It was possible to remove the pulses of somatostatin and glucagon with maintenance of the insulin rhythmicity by addition of 1 micromol/l of the P2Y(1) receptor antagonist MRS 2179...