Goran Hedenstierna

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. ncbi request reprint Mechanisms of atelectasis in the perioperative period
    Goran Hedenstierna
    Uppsala University, Dept of Medical Sciences, Clinical Physiology, 751 85 Uppsala, Sweden
    Best Pract Res Clin Anaesthesiol 24:157-69. 2010
  2. ncbi request reprint Esophageal pressure: benefit and limitations
    G Hedenstierna
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Minerva Anestesiol 78:959-66. 2012
  3. pmc Positive end-expiratory pressure optimization with forced oscillation technique reduces ventilator induced lung injury: a controlled experimental study in pigs with saline lavage lung injury
    Peter Kostic
    Dipartimento di Bioingegneria, Politecnico di Milano University, Piazza Leonardo da Vinci 32, Milan, Italy
    Crit Care 15:R126. 2011
  4. pmc Effect of sedation with detomidine and butorphanol on pulmonary gas exchange in the horse
    Görel Nyman
    Department of Environment and Health, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Skara, Sweden
    Acta Vet Scand 51:22. 2009
  5. ncbi request reprint Interfacing spontaneous breathing and mechanical ventilation. New insights
    G Hedenstierna
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Minerva Anestesiol 72:183-98. 2006
  6. ncbi request reprint The effects of anesthesia and muscle paralysis on the respiratory system
    Goran Hedenstierna
    Clinical Physiology, Department of Medical Sciences, University Hospital, 75185 Uppsala, Sweden
    Intensive Care Med 31:1327-35. 2005
  7. ncbi request reprint Functional lung unit in the pig
    G Hedenstierna
    Department of Clinical Physiology, University Hospital, S 751 85, Uppsala, Sweden
    Respir Physiol 120:139-49. 2000
  8. ncbi request reprint Gas exchange in the ventilated patient
    Goran Hedenstierna
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Curr Opin Crit Care 8:39-44. 2002
  9. doi request reprint Distant effects of nitric oxide inhalation in endotoxemic pigs
    Manja C A Nilsson
    Department of Anesthesiology and Intensive Care, Uppsala University, Uppsala
    Crit Care Med 38:242-8. 2010
  10. ncbi request reprint Change in expiratory flow detects partial endotracheal tube obstruction in pressure-controlled ventilation
    Rafael Kawati
    Department of Surgical Sciences Anesthesiology and Intensive Care, Uppsala University Hospital, Uppsala, Sweden
    Anesth Analg 103:650-7. 2006

Detail Information

Publications69

  1. ncbi request reprint Mechanisms of atelectasis in the perioperative period
    Goran Hedenstierna
    Uppsala University, Dept of Medical Sciences, Clinical Physiology, 751 85 Uppsala, Sweden
    Best Pract Res Clin Anaesthesiol 24:157-69. 2010
    ..Thus, recruitment must be followed by ventilation with moderate FIO2...
  2. ncbi request reprint Esophageal pressure: benefit and limitations
    G Hedenstierna
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Minerva Anestesiol 78:959-66. 2012
    ..Diaphragm function can be estimated by esophageal minus gastric pressure and with even more precision, when combined with diaphragm electromyography...
  3. pmc Positive end-expiratory pressure optimization with forced oscillation technique reduces ventilator induced lung injury: a controlled experimental study in pigs with saline lavage lung injury
    Peter Kostic
    Dipartimento di Bioingegneria, Politecnico di Milano University, Piazza Leonardo da Vinci 32, Milan, Italy
    Crit Care 15:R126. 2011
    ..The aim of the present study was to evaluate if using Xrs for setting PEEP would improve lung mechanics and reduce lung injury compared to an oxygenation-based approach...
  4. pmc Effect of sedation with detomidine and butorphanol on pulmonary gas exchange in the horse
    Görel Nyman
    Department of Environment and Health, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Skara, Sweden
    Acta Vet Scand 51:22. 2009
    ..The present study was undertaken to investigate pulmonary gas exchange using the Multiple Inert Gas Elimination Technique (MIGET), during sedation with the alpha2-agonist detomidine alone and in combination with the opioid butorphanol...
  5. ncbi request reprint Interfacing spontaneous breathing and mechanical ventilation. New insights
    G Hedenstierna
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Minerva Anestesiol 72:183-98. 2006
    ....
  6. ncbi request reprint The effects of anesthesia and muscle paralysis on the respiratory system
    Goran Hedenstierna
    Clinical Physiology, Department of Medical Sciences, University Hospital, 75185 Uppsala, Sweden
    Intensive Care Med 31:1327-35. 2005
    ..Moreover, postoperative lung complications occur in 3-10% after elective abdominal surgery and more in emergency operations...
  7. ncbi request reprint Functional lung unit in the pig
    G Hedenstierna
    Department of Clinical Physiology, University Hospital, S 751 85, Uppsala, Sweden
    Respir Physiol 120:139-49. 2000
    ....
  8. ncbi request reprint Gas exchange in the ventilated patient
    Goran Hedenstierna
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Curr Opin Crit Care 8:39-44. 2002
    ..Increased knowledge in this area may, in the future, make inhaled nitric oxide more attractive in the treatment of adult respiratory failure as well as in neonatal intensive care...
  9. doi request reprint Distant effects of nitric oxide inhalation in endotoxemic pigs
    Manja C A Nilsson
    Department of Anesthesiology and Intensive Care, Uppsala University, Uppsala
    Crit Care Med 38:242-8. 2010
    ..The aim of this study was to investigate whether INO has distant effects in endotoxemic pig lungs. The hypothesis was that INO down-regulates endogenous NO production in lung regions not reached by INO...
  10. ncbi request reprint Change in expiratory flow detects partial endotracheal tube obstruction in pressure-controlled ventilation
    Rafael Kawati
    Department of Surgical Sciences Anesthesiology and Intensive Care, Uppsala University Hospital, Uppsala, Sweden
    Anesth Analg 103:650-7. 2006
    ..0, 8.0, 7.0, and 6.0 respectively). We conclude that when the elastic recoil that drives (e) is appropriately considered, analysis of (e) and V(ex fract,15) detects partial ETT obstruction during PCV...
  11. ncbi request reprint Comparisons of effects of intravenous and inhaled methacholine on airway physiology in a murine asthma model
    Sofia Jonasson
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Respir Physiol Neurobiol 165:229-36. 2009
    ..The two methods of MCh delivery have important advantages but also certain limitations with regard to measuring airway reactivity in a murine model of allergic asthma...
  12. ncbi request reprint Early inflammation mainly affects normally and poorly aerated lung in experimental ventilator-induced lung injury*
    João Batista Borges
    1Hedenstierna Laboratory, Department of Surgical Sciences, Section of Anaesthesiology and Critical Care, Uppsala University, Uppsala, Sweden 2Pulmonary Divison, Heart Institute InCor Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil 3Research and Education Institute, Hospital Sirio Libanes, Sao Paulo, Brazil 4Centros de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain 5Department of Hospital Physics, Uppsala University Hospital, Uppsala, Sweden 6Hedenstierna Laboratory, Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Crit Care Med 42:e279-87. 2014
    ..The aim of this study was to assess the location and magnitude of lung inflammation using PET imaging of [(18)F]fluoro-2-deoxy-D-glucose in a porcine experimental model of early acute respiratory distress syndrome...
  13. ncbi request reprint Multiple inert gas elimination technique by micropore membrane inlet mass spectrometry--a comparison with reference gas chromatography
    Moritz Kretzschmar
    Department of Surgical Sciences, Anesthesia and Intensive Care, Uppsala University, Uppsala, Sweden
    J Appl Physiol (1985) 115:1107-18. 2013
    ..In conclusion, MMIMS enables faster measurement of VA/Q, is less demanding than GC, and produces comparable results. ..
  14. doi request reprint Allergen-induced formation of F2-isoprostanes in a murine asthma model identifies oxidative stress in acute airway inflammation in vivo
    Sofia Jonasson
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Prostaglandins Leukot Essent Fatty Acids 80:1-7. 2009
    ..This study showed an accumulation of F(2)-isoprostanes in acute airway inflammation and a markedly increased tissue damage caused by oxidative stress in an ongoing inflammation...
  15. doi request reprint Pulmonary shunt is independent of decrease in cardiac output during unsupported spontaneous breathing in the pig
    Laszlo Vimlati
    Department of Surgical Sciences, Anesthesiology and Critical Care, Uppsala University, Uppsala, Sweden
    Anesthesiology 118:914-23. 2013
    ..The CO dependency of the calculated venous admixture was investigated, with both minor and major shunt, during unsupported SB, MV, and SB with continuous positive airway pressure (CPAP)...
  16. pmc Different effects of deep inspirations on central and peripheral airways in healthy and allergen-challenged mice
    Sofia Jonasson
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Respir Res 9:23. 2008
    ..We have characterized the effects of DI on lung mechanics during mechanical ventilation in healthy mice and in a murine model of acute and chronic airway inflammation...
  17. ncbi request reprint Deep-breathing exercises reduce atelectasis and improve pulmonary function after coronary artery bypass surgery
    Elisabeth Westerdahl
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Chest 128:3482-8. 2005
    ..To investigate the effects of deep-breathing exercises on pulmonary function, atelectasis, and arterial blood gas levels after coronary artery bypass graft (CABG) surgery...
  18. ncbi request reprint Lung aeration during sleep in patients with obstructive sleep apnoea
    Jonas Appelberg
    Department of Clinical Physiology, Sundsvall Hospital, Sundsvall, Sweden
    Clin Physiol Funct Imaging 30:301-7. 2010
    ..However, little is known about regional lung aeration during sleep in patients with OSA...
  19. doi request reprint Ventilation distribution studies comparing Technegas and "Gallgas" using 68GaCl3 as the label
    João Batista Borges
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    J Nucl Med 52:206-9. 2011
    ..Ventilation distribution can be assessed by SPECT with Technegas. This study was undertaken in piglets with different degrees of ventilation inhomogeneity to compare PET using (68)Ga-labeled pseudogas or "Gallgas" with Technegas...
  20. doi request reprint Corrections of Enghoff's dead space formula for shunt effects still overestimate Bohr's dead space
    Fernando Suarez-Sipmann
    Department of Surgical Sciences, Section of Anesthesiology and Critical Care, Uppsala University, Uppsala, Sweden Instituto de Investigación Sanitaria, Fundacion Jimenez Diaz, IIS FJD, Madrid, Spain CIBERES, Spain Electronic address
    Respir Physiol Neurobiol 189:99-105. 2013
    ..64 ± 0.09, bias 0.048, limits of agreement -0.168 to 0.072; p < 0.05). Neither Kuwabara's nor Niklason's algorithms were able to correct Enghoff's dead space formula for shunt effects...
  21. ncbi request reprint Abdominal lymph flow in an endotoxin sepsis model: influence of spontaneous breathing and mechanical ventilation
    Marco Lattuada
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Crit Care Med 34:2792-8. 2006
    ..We also compared the effect on thoracic duct lymph flow of mechanical ventilation with different levels of positive end-expiratory pressure (PEEP) and spontaneous breathing with continuous positive airway pressure (CPAP)...
  22. ncbi request reprint Effects of acepromazine on pulmonary gas exchange and circulation during sedation and dissociative anaesthesia in horses
    Stina Marntell
    Department of Large Animal Clinical Sciences, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Vet Anaesth Analg 32:83-93. 2005
    ..To study pulmonary gas exchange and cardiovascular responses to sedation achieved with romifidine and butorphanol (RB) alone, or combined with acepromazine, and during subsequent tiletamine-zolazepam anaesthesia in horses...
  23. ncbi request reprint Cyclooxygenase inhibitor blocks rebound response after NO inhalation in an endotoxin model
    Luni Chen
    Department of Medical Sciences, Clinical Physiology, University Hospital, SE 751 85 Uppsala, Sweden
    Am J Physiol Heart Circ Physiol 284:H290-8. 2003
    ..We conclude that the rebound response to INO discontinuation is related to COX products...
  24. ncbi request reprint The immediate effects of deep breathing exercises on atelectasis and oxygenation after cardiac surgery
    Elisabeth Westerdahl
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Scand Cardiovasc J 37:363-7. 2003
    ..Conclusion--A significant decrease of atelectatic area, increase in aerated lung area and a small increase in PaO (2) were found after performance of 30 deep breaths. No difference between the three breathing techniques was found...
  25. doi request reprint Lung aeration during ventilation after recruitment guided by tidal elimination of carbon dioxide and dynamic compliance was better than after end-tidal carbon dioxide targeted ventilation: a computed tomography study in surfactant-depleted piglets
    Angela Hanson
    The Department of Paediatric Anaesthesia and Intensive Care, The Queen Silvia Children s Hospital, University of Gothenburg, Goteborg, Sweden
    Pediatr Crit Care Med 12:e362-8. 2011
    ....
  26. doi request reprint Evaluating abdominal oedema during experimental sepsis using an isotope technique
    Marco Lattuada
    Hedenstierna Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Clin Physiol Funct Imaging 32:197-204. 2012
    ..Abdominal oedema is common in sepsis. A technique for the study of such oedema may guide in the fluid regime of these patients...
  27. doi request reprint Regional lung perfusion estimated by electrical impedance tomography in a piglet model of lung collapse
    João Batista Borges
    Department of Surgical Sciences, Section of Anaesthesiology and Critical Care, Uppsala University, Uppsala, Sweden
    J Appl Physiol (1985) 112:225-36. 2012
    ..The method proposed in this study has the potential to contribute to a better understanding of the behavior of regional perfusion under different lung and therapeutic conditions...
  28. ncbi request reprint Peak airway pressure increase is a late warning sign of partial endotracheal tube obstruction whereas change in expiratory flow is an early warning sign
    Rafael Kawati
    Department of Surgical Sciences Anesthesiology and Intensive Care, Uppsala University Hospital, SE 75185, Uppsala, Sweden
    Anesth Analg 100:889-93, table of contents. 2005
    ..We conclude that partial obstruction of the ETT can be reliably monitored with the expiratory V signal and has the potential of monitoring ETT narrowing in ventilator-dependent patients independent of the inspiratory pattern applied...
  29. ncbi request reprint The central circulation in congestive heart failure non-invasively evaluated with dynamic positron emission tomography
    Jens Sorensen
    Department of Medical Sciences, Clinical Physiology, Academic Hospital, Uppsala, Sweden
    Clin Physiol Funct Imaging 26:171-7. 2006
    ....
  30. ncbi request reprint Effects of hyperosmolarity and airway epithelial ion transport inhibitors on sodium nitroprusside-induced relaxation of guinea pig trachea
    Josephine Hjoberg
    Department of Medical Sciences, Clinical Physiology, University Hospital, S 751 85 Uppsala, Sweden
    Respir Physiol Neurobiol 146:239-46. 2005
    ....
  31. doi request reprint Respiratory function during anesthesia: effects on gas exchange
    Goran Hedenstierna
    Department of Medical Sciences, Clinical Physiology, Uppsala University Hospital, Uppsala, Sweden
    Compr Physiol 2:69-96. 2012
    ..CO2 pneumoperitoneum increases atelectasis formation but not shunt, likely explained by enhanced hypoxic pulmonary vasoconstriction by CO2. Atelectasis may persist in the postoperative period and contribute to pneumonia...
  32. ncbi request reprint Lung aeration during sleep
    Jonas Appelberg
    Department of Clinical Physiology, Sundsvall Hospital, Sundsvall, Sweden
    Chest 131:122-9. 2007
    ..During sleep, ventilation and functional residual capacity (FRC) decrease slightly. This study addresses regional lung aeration during wakefulness and sleep...
  33. doi request reprint Lung sound analysis correlates to injury and recruitment as identified by computed tomography: an experimental study
    Antonio Vena
    Department of Medical Sciences, Clinical Physiology, Uppsala University Hospital, Uppsala, Sweden
    Intensive Care Med 37:1378-83. 2011
    ..The aim of this study is to assess how analysis of the spectral characteristics of lung sounds can help in detecting lung injury and subsequent recruitment as verified by computed tomography (CT)...
  34. doi request reprint Prevention of atelectasis in morbidly obese patients during general anesthesia and paralysis: a computerized tomography study
    Henrik Reinius
    Department of Anesthesia and Intensive Care, University Hospital, Uppsala, Sweden
    Anesthesiology 111:979-87. 2009
    ..This study analyzed the effect of general anesthesia and three different ventilatory strategies to reduce the amount of atelectasis and improve respiratory function...
  35. doi request reprint Improved ventilation-perfusion matching with increasing abdominal pressure during CO(2) -pneumoperitoneum in pigs
    C M Strang
    Department of Medical Sciences, Clinical Physiology, University of Uppsala, Uppsala, Sweden
    Acta Anaesthesiol Scand 55:887-96. 2011
    ..CO(2) -pneumoperitoneum (PP) is performed at varying abdominal pressures. We studied in an animal preparation the effect of increasing abdominal pressures on gas exchange during PP...
  36. ncbi request reprint Acoustic effects of positive end-expiratory pressure on normal lung sounds in mechanically ventilated pigs
    Antonio Vena
    Department of Medical Sciences, Clinical Physiology, Uppsala University Hospital, Uppsala, Sweden
    Clin Physiol Funct Imaging 26:45-53. 2006
    ..The application of increasing levels of PEEP reduced the amplitude and changed the spectral characteristics of normal lung sounds...
  37. ncbi request reprint Glucocorticoid receptor function is decreased in neutrophils during endotoxic shock
    Maria Bergquist
    Department of Medical Sciences, The Hedenstierna Laboratory, Uppsala University, Sweden Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Sweden Electronic address
    J Infect 69:113-22. 2014
    ....
  38. doi request reprint Influence of abdominal pressure on respiratory and abdominal organ function
    Goran Hedenstierna
    Department of Clinical Physiology, Uppsala University, Uppsala, Sweden
    Curr Opin Crit Care 18:80-5. 2012
    ..Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) have been realized as severe complications in the intensive care patient. Laparoscopic surgery in older and more obese patients increases the risk of IAH and ACS...
  39. pmc Pharyngeal oxygen administration increases the time to serious desaturation at intubation in acute lung injury: an experimental study
    Joakim Engström
    Department of Anesthesiology and Intensive Care, Uppsala University, ANIVA ing 70 1tr, University Hospital, S 75185 Uppsala, Sweden
    Crit Care 14:R93. 2010
    ....
  40. doi request reprint Lymphatics and lymph in acute lung injury
    Goran Hedenstierna
    Department of Medical Sciences, Clinical Physiology, Uppsala University Hospital, Uppsala, Sweden
    Curr Opin Crit Care 14:31-6. 2008
    ..Lymph flow will be discussed as part of the drainage and fluid balance of lung tissue and abdomen as well as a qualitative analysis of inflammatory processes...
  41. ncbi request reprint Alveolar collapse and closure of airways: regular effects of anaesthesia
    Goran Hedenstierna
    Department of Clinical Physiology, University Hospital, Uppsala, Sweden
    Clin Physiol Funct Imaging 23:123-9. 2003
    ..Avoiding high inspired oxygen fractions during both induction and maintenance of anaesthesia prevents or reduces atelectasis, while intermittent 'vital capacity' manoeuvres, recruit atelectatic lung regions...
  42. ncbi request reprint Nitric oxide up-regulates the glucocorticoid receptor and blunts the inflammatory reaction in porcine endotoxin sepsis
    Jiping Da
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala University, Sweden
    Crit Care Med 35:26-32. 2007
    ..We hypothesized that there may be an interaction between nitric oxide and glucocorticoids, with the potential to enhance the anti-inflammatory effect when administered simultaneously...
  43. ncbi request reprint Hyperosmolarity-induced relaxation and prostaglandin release in guinea pig trachea in vitro
    J Hjoberg
    Department of Medical Sciences, Clinical Physiology, University Hospital, S 751 85, Uppsala, Sweden
    Eur J Pharmacol 398:303-7. 2000
    ..This might be relevant for asthmatic patients since prostaglandin may modulate the bronchoconstrictive response to hyperosmolar stimuli and exercise...
  44. ncbi request reprint Ventilation-perfusion distributions in different porcine lung injury models
    P Neumann
    Department of Clinical Physiology, University of Uppsala, Sweden
    Acta Anaesthesiol Scand 45:78-86. 2001
    ..Although V(A)/Q distributions can be related to pathogenic aspects of the three study groups, we did not observe specific V(A)/Q patterns which allow diagnosis of the type of lung injury from a recovered V(A)/Q distribution...
  45. pmc Hyperosmolarity reduces the relaxing potency of nitric oxide donors in guinea-pig trachea
    J Hjoberg
    Department of Medical Sciences, Clinical Physiology, Uppsala University, University Hospital, Sweden
    Br J Pharmacol 127:391-6. 1999
    ..05) and hyperosmolar conditions (P<0.05). 6. The relaxant effect of nitric oxide donors on tracheal smooth muscle is markedly reduced when the airway epithelium is exposed to hyperosmolar solution...
  46. ncbi request reprint Hyperosmolarity decreases the relaxing potency of sodium nitroprusside on guinea-pig trachea by the release of superoxide anions
    J Hjoberg
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Acta Physiol Scand 178:279-83. 2003
    ..Increased osmolarity of the airway surface has been shown to abolish the airway relaxant effects of inhaled nitric oxide in rabbits in vivo and in guinea-pig trachea in vitro...
  47. ncbi request reprint Inhalation of nitric oxide in the treatment of severe acute respiratory syndrome: a rescue trial in Beijing
    Luni Chen
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Clin Infect Dis 39:1531-5. 2004
    ..These findings suggest not only a pulmonary vasodilator effect of inhaled NO, but also an effect on SARS...
  48. ncbi request reprint Decreasing size of cardiogenic oscillations reflects decreasing compliance of the respiratory system during long-term ventilation
    Michael Lichtwarck-Aschoff
    Department of Surgical, Uppsala University, Sweden
    J Appl Physiol (1985) 96:879-84. 2004
    ....
  49. doi request reprint Increased alveolar damage after mechanical ventilation in a porcine model of thoracic surgery
    Alf Kozian
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    J Cardiothorac Vasc Anesth 24:617-23. 2010
    ..This study compared the effects of mechanical ventilation, OLV, and surgical manipulation on diffuse alveolar damage (DAD) after application of different anesthetic regimens...
  50. ncbi request reprint Optimal oxygen concentration during induction of general anesthesia
    Lennart Edmark
    Department of Anesthesiology and Intensive Care, Central Hospital, Vasteras, and Research Associate, Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Anesthesiology 98:28-33. 2003
    ..The use of 100% oxygen during induction of anesthesia may produce atelectasis. The authors investigated how different oxygen concentrations affect the formation of atelectasis and the fall in arterial oxygen saturation during apnea...
  51. pmc Association between inflammatory mediators and response to inhaled nitric oxide in a model of endotoxin-induced lung injury
    Sebastien Trachsel
    Department of Medical Sciences, Clinical Physiology, Uppsala University, S 75185 Uppsala, Sweden
    Crit Care 12:R131. 2008
    ..The aim of the present study was to identify, within a panel of inflammatory mediators released during endotoxin-induced lung injury, specific mediators that are associated with a PaO2 response to INO...
  52. ncbi request reprint High inspired oxygen concentrations increase intrapulmonary shunt in anaesthetized horses
    Stina Marntell
    Department of Large Animal Clinical Sciences, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Vet Anaesth Analg 32:338-47. 2005
    ..To compare pulmonary function and gas exchange in anaesthetized horses during and after breathing either O2-rich gas mixtures or air...
  53. ncbi request reprint Atelectasis and gas exchange after cardiac surgery
    A Tenling
    Department of Cardiothoracic Anesthesia, University Hospital, Uppsala, Sweden
    Anesthesiology 89:371-8. 1998
    ..Animal studies have shown that postoperative shunt can be explained by atelectasis. In this study the authors tried to determine if atelectasis can explain shunt in patients who have had cardiac surgery...
  54. ncbi request reprint Ventilatory support by continuous positive airway pressure breathing improves gas exchange as compared with partial ventilatory support with airway pressure release ventilation
    P Neumann
    Department of Clinical Physiology, University of Uppsala, Sweden
    Anesth Analg 92:950-8. 2001
    ..Therefore, mechanical ventilatory support achieved by a cyclic release of airway pressure during APRV should be kept at the minimum level that enables enough ventilatory support for patients to avoid respiratory muscle fatigue...
  55. ncbi request reprint Simple and accurate assessment of forward cardiac output by use of 1-(11)C-acetate PET verified in a pig model
    Jens Sorensen
    Department of Medical Sciences, Academic Hospital, Uppsala, Sweden
    J Nucl Med 44:1176-83. 2003
    ..Further, we wanted to investigate the pulmonary uptake of acetate in relation to left atrial filling pressures and ventricular function...
  56. ncbi request reprint Maintaining nitric oxide-induced airway relaxation with superoxide dismutase
    Claus G Krenn
    Department of Medical Sciences, Clinical Physiology, Uppsala University, SE 751 85 Uppsala, Sweden
    Nitric Oxide 16:419-24. 2007
    ..In this study, hypothesizing that the impaired efficiency of iNO was caused by release of reactive oxygen radicals, we examined the effect of the radical scavenging enzyme superoxide dismutase (SOD)...
  57. doi request reprint Concomitant administration of nitric oxide and glucocorticoids improves protection against bronchoconstriction in a murine model of asthma
    Sofia Jonasson
    Dept of Medical Sciences, Clinical Physiology, University Hospital, SE 751 85 Uppsala, Sweden
    J Appl Physiol (1985) 109:521-31. 2010
    ....
  58. ncbi request reprint Endothelin-1 and nitric oxide synthase in short rebound reaction to short exposure to inhaled nitric oxide
    L Chen
    Department of Clinical Physiology, University Hospital, S-75185 Uppsala, Sweden
    Am J Physiol Heart Circ Physiol 281:H124-31. 2001
    ..Activity of constitutive NOS decreased during INO, whereas that of inducible NOS was unchanged. Upregulation of ET-1 and downregulation of NOS activity may have influenced the short rebound reaction to short-term INO...
  59. ncbi request reprint Good short-term agreement between measured and calculated tracheal pressure
    M Lichtwarck-Aschoff
    Department of Surgical Sciences, Section of Anaesthesiology and Intensive Care Medicine, Uppsala University, Sweden
    Br J Anaesth 91:239-48. 2003
    ..P(tr) can either be measured with a catheter or, alternatively, calculated from the pressure-flow data available from the ventilator...
  60. doi request reprint Ventilation-perfusion distributions and gas exchange during carbon dioxide-pneumoperitoneum in a porcine model
    C M Strang
    Department of Medical Sciences and Clinical Physiology, Uppsala University, Sweden
    Br J Anaesth 105:691-7. 2010
    ..This seeming paradox prompted the present animal study on the effects of PP on ventilation-perfusion distribution (V/Q) and gas exchange...
  61. doi request reprint Expression of the glucocorticoid receptor is decreased in experimental Staphylococcus aureus sepsis
    Maria Bergquist
    Department of Medical Sciences, The Hedenstierna Laboratory, Uppsala University, Sweden Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Sweden Electronic address
    J Infect 67:574-83. 2013
    ..The impact of timing of dexamethasone treatment was also investigated...
  62. ncbi request reprint An animal model of response and nonresponse to inhaled nitric oxide in endotoxin-induced lung injury
    H Maurenbrecher
    Department of Clinical Physiology, University Hospital, Uppsala, Sweden
    Chest 120:573-81. 2001
    ..04). CONCLUSION: Response to inhaled NO is abolished over time in endotoxin-induced ARDS pig lungs. The response seems to be related to the degree of / mismatch, which may indicate an important role of hypoxic pulmonary vasoconstriction...
  63. ncbi request reprint Pulmonary perfusion during anesthesia and mechanical ventilation
    G Hedenstierna
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Minerva Anestesiol 71:319-24. 2005
    ..Recruitment manoeuvres shall be directed to the ventilated lung and other physical and pharmacological measures can be taken to manipulate blood flow in one lung anesthesia...
  64. ncbi request reprint Compliance is nonlinear over tidal volume irrespective of positive end-expiratory pressure level in surfactant-depleted piglets
    M Lichtwarck-Aschoff
    Department of Surgical Sciences, University Hospital, Uppsala, Sweden
    Am J Respir Crit Care Med 162:2125-33. 2000
    ....
  65. doi request reprint Lung computed tomography density distribution in a porcine model of one-lung ventilation
    A Kozian
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Sweden
    Br J Anaesth 102:551-60. 2009
    ..One-lung ventilation (OLV) exposes the dependent lung to increased mechanical stress which may affect the postoperative course. This study evaluates regional pulmonary gas/tissue distribution in a porcine model of OLV...
  66. ncbi request reprint Assessing dead space. A meaningful variable?
    G Hedenstierna
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Minerva Anestesiol 72:521-8. 2006
    ..It should therefore not be forgotten in the intensive care setting...
  67. ncbi request reprint Airway closure, atelectasis and gas exchange during anaesthesia
    G Hedenstierna
    Department of Clinical Physiology, University Hospital, Uppsala, Sweden
    Minerva Anestesiol 68:332-6. 2002
    ..Lowering the inspired O2 concentration to 80% suffices to avoid almost all atelectasis. Airway closure and low VA/Q can only be prevented by raising the FRC level by PEEP or by other means...
  68. ncbi request reprint Thoracic epidural analgesia as an adjunct to general anaesthesia for cardiac surgery. Effects on pulmonary mechanics
    A Tenling
    Departments of Cardiothoracic Anaesthesiology, University Hospital, Uppsala, Sweden
    Acta Anaesthesiol Scand 44:1071-6. 2000
    ..We examined the effects of TEA on pulmonary function and ventilation at rest, before and after coronary artery bypass graft surgery (CABG)...
  69. doi request reprint Development of atelectasis and arterial to end-tidal PCO2-difference in a porcine model of pneumoperitoneum
    C M Strang
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Br J Anaesth 103:298-303. 2009
    ..The present study was undertaken to study the effects of CO2-pneumoperitoneum (CO2-PP) on atelectasis formation, arterial oxygenation, and arterial to end-tidal PCO2-gradient (Pa-E'(CO2))...