Research Topics
Species | T FurmarkSummaryAffiliation: Uppsala University Country: Sweden Publications
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Publications
Cerebral blood flow changes after treatment of social phobia with the neurokinin-1 antagonist GR205171, citalopram, or placeboTomas Furmark
Department of Psychology, Uppsala University, Uppsala, Sweden
Biol Psychiatry 58:132-42. 2005..This study compared the effects of an NK1 receptor antagonist, citalopram, and placebo on brain activity and anxiety symptoms in social phobia...
Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapyTomas Furmark
Department of Psychology, Uppsala University, Box 1225, SE 751 42 Uppsala, Sweden
Arch Gen Psychiatry 59:425-33. 2002..Neurofunctional changes underlying effective antianxiety treatments are incompletely characterized. This study explored the effects of citalopram and cognitive-behavioral therapy on regional cerebral blood flow (rCBF) in social phobia...
Social phobia: overview of community surveysT Furmark
Department of Psychology, Uppsala University, Uppsala, Sweden
Acta Psychiatr Scand 105:84-93. 2002..This paper presents an overview of community studies that have estimated the prevalence of social phobia, its subtypes, and specific social fears in the adult general population. Sociodemographic findings are also summarized...
A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxietyTomas Furmark
Department of Psychology, Uppsala University, Uppsala, Sweden
J Neurosci 28:13066-74. 2008..Hence, our study shows, for the first time, evidence of a link between genetically controlled serotonergic modulation of amygdala activity and placebo-induced anxiety relief...
Genotype over-diagnosis in amygdala responsiveness: affective processing in social anxiety disorderTomas Furmark
Department of Psychology, Uppsala University, Uppsala, Sweden
J Psychiatry Neurosci 34:30-40. 2009..We investigated the influence of these polymorphisms on amygdala responsiveness to angry faces in patients with social anxiety disorder (SAD) compared with healthy controls...
Neurobiological aspects of social anxiety disorderTomas Furmark
Department of Psychology, Uppsala University, Uppsala, Sweden
Isr J Psychiatry Relat Sci 46:5-12. 2009..It is also suggested that serotonin-related gene polymorphisms are important for amygdala responsivity and treatment outcome in SAD...
Social phobia in the general population: prevalence and sociodemographic profileT Furmark
Department of Psychology, Uppsala University, Box 1225, SE 751 42 Uppsala, Sweden
Soc Psychiatry Psychiatr Epidemiol 34:416-24. 1999..The present study examined the prevalence of social phobia in the Swedish general population and demographic characteristics associated with this anxiety disorder...
Guided and unguided self-help for social anxiety disorder: randomised controlled trialTomas Furmark
Department of Psychology, Uppsala University, Box 1225, SE 751 42 Uppsala, Sweden
Br J Psychiatry 195:440-7. 2009..Internet-delivered self-help programmes with added therapist guidance have shown efficacy in social anxiety disorder, but unguided self-help has been insufficiently studied...
Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobiaTomas Furmark
Department of Psychology, Uppsala University, Uppsala, Sweden
Neurosci Lett 362:189-92. 2004..Thus, 5-HTT genetic variation was associated with symptom severity and amygdala excitability in social phobia...
Human fear reconsolidation and allelic differences in serotonergic and dopaminergic genesT Agren
Department of Psychology, Uppsala University, Uppsala, Sweden
Transl Psychiatry 2:e76. 2012..These results demonstrate that reconsolidation of human fear memory is influenced by dopamine and serotonin-related genes...
Cerebral blood flow in subjects with social phobia during stressful speaking tasks: a PET studyM Tillfors
Department of Psychology, Uppsala University PET Center, SE 751 42 Uppsala, Sweden
Am J Psychiatry 158:1220-6. 2001..The central nervous system representation of social phobia (social anxiety disorder) is largely unknown. The aim of this study was to examine brain activity during symptom provocation in social phobics...
Social phobia and avoidant personality disorder as related to parental history of social anxiety: a general population studyM Tillfors
Department of Psychology, Uppsala University, Sweden
Behav Res Ther 39:289-98. 2001..Thus, having an affected family member is associated with a two- to three-fold risk increase for both social phobia and APD...
Functional neuroanatomical correlates of electrodermal activity: a positron emission tomographic studyM Fredrikson
Department of Psychology, Uppsala University, Sweden
Psychophysiology 35:179-85. 1998..Because these areas also support anticipation, affect, and locomotion, electrodermal responses seem to reflect cognitively or emotionally mediated motor preparation...
Regional cerebral blood flow during tinnitus: a PET case study with lidocaine and auditory stimulationG Andersson
Department of Audiology, Uppsala University Hospital, Uppsala University, Sweden
Acta Otolaryngol 120:967-72. 2000..Tinnitus perception may involve areas related to auditory attention, while emotional processing relates to temporofrontal paralimbic areas...
Personality traits in social phobiaI Marteinsdottir
Department of Neuroscience, Psychiatry, Uppsala University, SE 751 85 Uppsala, Sweden
Eur Psychiatry 16:143-50. 2001..Generally, the results support the view that social phobia and avoidant personality disorder reflect different aspects of a social anxiety spectrum...
Brain correlates of an unexpected panic attack: a human positron emission tomographic studyH Fischer
Department of Psychology, Uppsala University, Sweden
Neurosci Lett 251:137-40. 1998..These findings suggest that neural activity in brain regions previously associated with symptom provocation in specific phobics and subjects with posttraumatic stress disorder also are involved during panic in healthy individuals...
Imaging the placebo response: a neurofunctional reviewVanda Faria
Department of Psychology, Uppsala University, Uppsala, Sweden
Eur Neuropsychopharmacol 18:473-85. 2008..Placebo-induced clinical benefits also involve disorder-specific neuronal responses, yielding neurofunctional or neurochemical alterations similar to those produced by pharmacological treatments...
Disentangling the web of fear: amygdala reactivity and functional connectivity in spider and snake phobiaFredrik Ahs
Department of Psychology, Uppsala University, Uppsala, Sweden
Psychiatry Res 172:103-8. 2009....
High-frequency heart rate variability and cortico-striatal activity in men and women with social phobiaFredrik Ahs
Department of Psychology, Uppsala University, Box 1225, SE 751 42 Uppsala, Sweden
Neuroimage 47:815-20. 2009..Moreover, caudate functions, possibly related to dopaminergic neurotransmission, have sexually dimorphic effects on vagal modulation of the heart...
Ventromedial prefrontal neurokinin 1 receptor availability is reduced in chronic painClas Linnman
Department of Psychology, Uppsala University, Uppsala, Sweden
Pain 149:64-70. 2010..We conclude that the central NK1 receptor system is altered in human chronic pain. The results suggest that NK1 receptors in the vmPFC modulate motor inhibition, and contribute to fear and avoidance of movement...
Chronic whiplash symptoms are related to altered regional cerebral blood flow in the resting stateClas Linnman
Department of Psychology, Uppsala University, Box 1225, SE 751 42 Uppsala, Sweden
Eur J Pain 13:65-70. 2009..We thus suggest an involvement of the posterior cingulate, parahippocampal and medial prefrontal gyri in WAD and speculate that alterations in the resting state are linked to an increased self-relevant evaluation of pain and stress...
Amygdaloid regional cerebral blood flow and subjective fear during symptom provocation in anxiety disordersMats Fredrikson
Department of Psychology, Uppsala University, Uppsala, Sweden
Ann N Y Acad Sci 985:341-7. 2003....
Hypothalamic blood flow correlates positively with stress-induced cortisol levels in subjects with social anxiety disorderFredrik Ahs
Department of Psychology, Uppsala University, Box 1225, SE 751 42 Uppsala, Sweden
Psychosom Med 68:859-62. 2006..Another objective was to evaluate whether salivary cortisol levels correlated with rCBF in other brain areas...
Personality dimensions measured by the Temperament and Character Inventory (TCI) in subjects with social phobiaIna Marteinsdottir
Department of Neuroscience, Psychiatry, Uppsala University, Sweden
Nord J Psychiatry 57:29-35. 2003..Enhanced Harm avoidance was the most prominent personality trait. The observed deviations in TCI dimensions were primarily related to the social phobia itself and not to the presence of concurrent personality disorders...
Social phobia in Swedish university students: prevalence, subgroups and avoidant behaviorMaria Tillfors
Dept of Behavioral, Social and Legal Sciences, Orebro University, 701 82, Orebro, Sweden
Soc Psychiatry Psychiatr Epidemiol 42:79-86. 2007..The present study examined the prevalence of social phobia and its subgroups in a university student population. Demographic characteristics and avoidant behavior in educational settings were also examined...
Right-sided human prefrontal brain activation during acquisition of conditioned fearHakan Fischer
Aging Research Center, Karolinska Institute, Stockholm University, Sweden
Emotion 2:233-41. 2002..During acquisition, rCBF increased in the right medial frontal gyrus, supporting a role for the prefrontal cortex in fear conditioning to unmasked evolutionary fear-relevant stimuli...
Cerebral blood flow during anticipation of public speaking in social phobia: a PET studyMaria Tillfors
Department of Social Sciences, Orebro University, Orebro, Sweden
Biol Psychiatry 52:1113-9. 2002..We speculate that anticipatory anxiety in social phobics originates in an affect sensitive fear network encompassing the amygdaloid-hippocampal region, prefrontal, and temporal areas...
Social phobia and avoidant personality disorder: one spectrum disorder?Maria Tillfors
Department of Social Sciences, Orebro University, Sweden
Nord J Psychiatry 58:147-52. 2004....
Size and burden of social phobia in EuropeLydia Fehm
Department of Psychology, Humboldt University Berlin, Rudower Chaussee 18, D 12489 Berlin, Germany
Eur Neuropsychopharmacol 15:453-62. 2005..No data are available addressing met and unmet needs for intervention and costs, and data for vulnerability and risk factors of malignant course are scarce...
Consequences of suppressing thoughts about tinnitus and the effects of cognitive distraction on brain activity in tinnitus patientsGerhard Andersson
Department of Behavioural Sciences, Linkoping University, Linkoping, Sweden
Audiol Neurootol 11:301-9. 2006..Thus, distraction that altered the tinnitus experience seemed to attenuate auditory cortex activity...
Internet-based self-help with therapist feedback and in vivo group exposure for social phobia: a randomized controlled trialGerhard Andersson
Department of Behavioural Sciences, Linkoping University, Linkoping, Sweden
J Consult Clin Psychol 74:677-86. 2006..87 and 0.70, respectively. Treatment gains were maintained at 1-year follow-up. The results from this study support the continued use and development of Internet-distributed, self-help programs for people diagnosed with social phobia...
Treatment of social phobia: randomised trial of internet-delivered cognitive-behavioural therapy with telephone supportPer Carlbring
Linkoping University, Department of Behavioural Sciences, SE 581 83 Linkoping, Sweden
Br J Psychiatry 190:123-8. 2007..Internet-based cognitive-behavioural self-help can be an alternative, but adherence is a problem...
