Robert Fredriksson


Affiliation: Uppsala University
Country: Sweden


  1. Hägglund M, Hellsten S, Bagchi S, Philippot G, Löfqvist E, Nilsson V, et al. Transport of L-glutamine, L-alanine, L-arginine and L-histidine by the neuron-specific Slc38a8 (SNAT8) in CNS. J Mol Biol. 2015;427:1495-512 pubmed publisher
    ..In conclusion, the neuronal SLC38A8 has a broad amino acid transport profile and is the first identified neuronal System A transporter. This suggests a key role of SNAT8 in the glutamine/glutamate (GABA) cycle in the brain. ..
  2. Fredriksson R, Nordström K, Stephansson O, Hägglund M, Schioth H. The solute carrier (SLC) complement of the human genome: phylogenetic classification reveals four major families. FEBS Lett. 2008;582:3811-6 pubmed publisher
    ..This study represents the first overall genomic roadmap of the SLCs providing large sequence sets and clarifies the phylogenetic relationships among the families of the second largest group of membrane proteins. ..
  3. Caruso V, Hägglund M, Badiali L, Bagchi S, Roshanbin S, Ahmad T, et al. The G protein-coupled receptor GPR162 is widely distributed in the CNS and highly expressed in the hypothalamus and in hedonic feeding areas. Gene. 2014;553:1-6 pubmed publisher
  4. Krishnan A, Dnyansagar R, Almén M, Williams M, Fredriksson R, Manoj N, et al. The GPCR repertoire in the demosponge Amphimedon queenslandica: insights into the GPCR system at the early divergence of animals. BMC Evol Biol. 2014;14:270 pubmed publisher
    ..In summary, this study provides a framework to perform future experimental and comparative studies to further verify and understand the roles of GPCRs that predates the divergence of bilaterian and eumetazoan lineages. ..
  5. Haitina T, Fredriksson R, Foord S, Schioth H, Gloriam D. The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents. BMC Genomics. 2009;10:24 pubmed publisher
    ..The comparison of the dog, human and rodent repertoires revealed several examples of species-specific gene duplications and deletions. This information is useful in the selection of model organisms for pharmacological experiments. ..
  6. Nordström K, Fredriksson R, Schioth H. The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors. BMC Evol Biol. 2008;8:9 pubmed publisher
    ..G protein-coupled receptors (GPCRs) are one of the largest families of genes in mammals. Branchiostoma floridae (amphioxus) is one of the species most closely related species to vertebrates...
  7. Västermark Å, Almén M, Simmen M, Fredriksson R, Schioth H. Functional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of Viridiplantae. BMC Evol Biol. 2011;11:123 pubmed publisher
    ..The nucleotide sugar transporters families were formed through differentiation of the gene cluster EamA (domain unknown function 6) before Viridiplantae, showing for the first time the significance of EamA. ..
  8. Haitina T, Klovins J, Takahashi A, Löwgren M, Ringholm A, Enberg J, et al. Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes. BMC Evol Biol. 2007;7:101 pubmed
    ..This study shows presence of MC receptors in agnathans indicating early signs of specific functions of melanocortin receptor subtypes. ..
  9. Eriksson A, Williams M, Voisin S, Hansson I, Krishnan A, Philippot G, et al. Implication of coronin 7 in body weight regulation in humans, mice and flies. BMC Neurosci. 2015;16:13 pubmed publisher
    ..We conclude that coronin 7 is involved in the regulation of energy homeostasis and this role stems, to some degree, from the effect on feeding for calories and reward. ..

More Information


  1. Krishnan A, Mustafa A, Almén M, Fredriksson R, Williams M, Schiöth H. Evolutionary hierarchy of vertebrate-like heterotrimeric G protein families. Mol Phylogenet Evol. 2015;91:27-40 pubmed publisher
    ..Our robust classification/hierarchy is essential to further understand the differential roles of GPCR/G protein mediated intracellular signaling system across various metazoan lineages. ..
  2. Roshanbin S, Hellsten S, Tafreshiha A, Zhu Y, Raine A, Fredriksson R. PAT4 is abundantly expressed in excitatory and inhibitory neurons as well as epithelial cells. Brain Res. 2014;1557:12-25 pubmed publisher
    ..Phylogenetic analysis showed that PAT4 belongs to an evolutionary old family most likely predating animals, and PAT4 is the oldest member of that family. ..
  3. Almén M, Nordström K, Fredriksson R, Schioth H. Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin. BMC Biol. 2009;7:50 pubmed publisher