U J Eriksson

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. ncbi request reprint Pregnant diabetic rats fed the antioxidant butylated hydroxytoluene show decreased occurrence of malformations in offspring
    U J Eriksson
    Department of Medical Cell Biology, University of Uppsala, Sweden
    Diabetes 45:1497-502. 1996
  2. ncbi request reprint Pathogenesis of diabetes-induced congenital malformations
    U J Eriksson
    Department of Medical Cell Biology, Uppsala University, Sweden
    Ups J Med Sci 105:53-84. 2000
  3. ncbi request reprint Congenital malformations in offspring of diabetic mothers--animal and human studies
    Ulf J Eriksson
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Rev Endocr Metab Disord 4:79-93. 2003
  4. ncbi request reprint Teratogenicity of 3-deoxyglucosone and diabetic embryopathy
    U J Eriksson
    Department of Medical Cell Biology, University of Uppsala, Sweden
    Diabetes 47:1960-6. 1998
  5. doi request reprint Genetic and environmental influence on diabetic rat embryopathy
    A Ejdesjö
    Dept of Medical Cell Biology, Biomedical Centre, Uppsala, Sweden
    Am J Physiol Endocrinol Metab 300:E454-67. 2011
  6. ncbi request reprint Vitamin E decreases the occurrence of malformations in the offspring of diabetic rats
    C M Simán
    Department of Medical Cell Biology, Uppsala University, Sweden
    Diabetes 46:1054-61. 1997
  7. ncbi request reprint Combined treatment with vitamin E and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy
    J Cederberg
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Pediatr Res 49:755-62. 2001
  8. ncbi request reprint Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment
    P Wentzel
    Department of Medical Cell Biology, University of Uppsala, Biomedicum, Sweden
    Diabetes 48:813-20. 1999
  9. ncbi request reprint Antioxidants diminish developmental damage induced by high glucose and cyclooxygenase inhibitors in rat embryos in vitro
    P Wentzel
    Department of Medical Cell Biology, University of Uppsala, Biomedicum, Sweden
    Diabetes 47:677-84. 1998
  10. ncbi request reprint Decreased catalase activity in malformation-prone embryos of diabetic rats
    J Cederberg
    Department of Medical Cell Biology, University of Uppsala, Sweden
    Teratology 56:350-7. 1997

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Pregnant diabetic rats fed the antioxidant butylated hydroxytoluene show decreased occurrence of malformations in offspring
    U J Eriksson
    Department of Medical Cell Biology, University of Uppsala, Sweden
    Diabetes 45:1497-502. 1996
    ..These data support the notion that an excess of free oxygen radicals in the embryo contributes to the teratogenic process of diabetic pregnancy and, thus, suggest an area for future preventive therapeutic treatment...
  2. ncbi request reprint Pathogenesis of diabetes-induced congenital malformations
    U J Eriksson
    Department of Medical Cell Biology, Uppsala University, Sweden
    Ups J Med Sci 105:53-84. 2000
    ....
  3. ncbi request reprint Congenital malformations in offspring of diabetic mothers--animal and human studies
    Ulf J Eriksson
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Rev Endocr Metab Disord 4:79-93. 2003
  4. ncbi request reprint Teratogenicity of 3-deoxyglucosone and diabetic embryopathy
    U J Eriksson
    Department of Medical Cell Biology, University of Uppsala, Sweden
    Diabetes 47:1960-6. 1998
    ..In addition, the anti-teratogenic effect of SOD administration appears to occur downstream of 3-DG formation, suggesting that 3-DG accumulation leads to superoxide-mediated embryopathy...
  5. doi request reprint Genetic and environmental influence on diabetic rat embryopathy
    A Ejdesjö
    Dept of Medical Cell Biology, Biomedical Centre, Uppsala, Sweden
    Am J Physiol Endocrinol Metab 300:E454-67. 2011
    ....
  6. ncbi request reprint Vitamin E decreases the occurrence of malformations in the offspring of diabetic rats
    C M Simán
    Department of Medical Cell Biology, Uppsala University, Sweden
    Diabetes 46:1054-61. 1997
    ....
  7. ncbi request reprint Combined treatment with vitamin E and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy
    J Cederberg
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Pediatr Res 49:755-62. 2001
    ..Oxidatively modified proteins may be teratogenically important mediators in diabetic embryopathy...
  8. ncbi request reprint Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment
    P Wentzel
    Department of Medical Cell Biology, University of Uppsala, Biomedicum, Sweden
    Diabetes 48:813-20. 1999
    ..This may explain in part the antiteratogenic effect of antioxidant treatment...
  9. ncbi request reprint Antioxidants diminish developmental damage induced by high glucose and cyclooxygenase inhibitors in rat embryos in vitro
    P Wentzel
    Department of Medical Cell Biology, University of Uppsala, Biomedicum, Sweden
    Diabetes 47:677-84. 1998
    ..In conclusion, the present study shows that a high glucose concentration disturbs embryonic development and that this disturbance may be partly mediated via altered metabolism of arachidonic acid and ROS in the embryo...
  10. ncbi request reprint Decreased catalase activity in malformation-prone embryos of diabetic rats
    J Cederberg
    Department of Medical Cell Biology, University of Uppsala, Sweden
    Teratology 56:350-7. 1997
    ....
  11. ncbi request reprint Increased rate of lipid peroxidation and protein carbonylation in experimental diabetic pregnancy
    J Cederberg
    Department of Medical Cell Biology, Uppsala University, Sweden
    Diabetologia 44:766-74. 2001
    ..CONCLUSIONS/INTERPRETATION: In diabetic pregnancy, both diabetes and pregnancy are promoting oxygen radical damage. Fetal oxidative stress markers do not clearly reflect fetal morphology...
  12. ncbi request reprint Induction of embryonic dysmorphogenesis by high glucose concentration, disturbed inositol metabolism, and inhibited protein kinase C activity
    P Wentzel
    Department of Medical Cell Biology, Uppsala University, Biomedical Center, SE 751 23 Uppsala, Sweden
    Teratology 63:193-201. 2001
    ..The aim of the present work was to study whether embryonic dysmorphogenesis is also dependent on alterations of inositol and associated intracellular metabolites...
  13. ncbi request reprint Antioxidative treatment of pregnant diabetic rats diminishes embryonic dysmorphogenesis
    Jonas Cederberg
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Birth Defects Res A Clin Mol Teratol 73:498-505. 2005
    ....
  14. doi request reprint Maternal blood glucose levels determine the severity of diabetic embryopathy in mice with different expression of copper-zinc superoxide dismutase (CuZnSOD)
    Sheller Zabihi
    Department of Medical Cell Biology, Uppsala University, Biomedical Center, SE 75123 Uppsala, Sweden
    Toxicol Sci 105:166-72. 2008
    ..However, the maternal diabetic state is the major teratogenic factor and overrides the influence of fetal antioxidative capacity...
  15. ncbi request reprint Effect of butylated hydroxytoluene on alpha-tocopherol content in liver and adipose tissue of rats
    C M Simán
    Department of Medical Cell Biology, University of Uppsala, Sweden
    Toxicol Lett 87:103-8. 1996
    ..Adipose tissue lacks the cytochrome P450 system. Therefore, the decreased hepatic concentration of alpha-tocopherol may be a consequence of a BHT-induced, free oxygen radical mediated, depletion of this antioxidant...
  16. doi request reprint Altered uterine perfusion is involved in fetal outcome of diabetic rats
    S Zabihi
    Department of Medical Cell Biology, Box 571, Husargatan 3, Uppsala University, SE 751 23 Uppsala, Sweden
    Placenta 29:413-21. 2008
    ..Maternal diabetes causes decreased expression of anti-oxidative enzymes and enhanced angiogenesis in the offspring in rats...
  17. ncbi request reprint Folic acid supplementation affects ROS scavenging enzymes, enhances Vegf-A, and diminishes apoptotic state in yolk sacs of embryos of diabetic rats
    Sheller Zabihi
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Reprod Toxicol 23:486-98. 2007
    ..FA administration normalizes vascular morphology, diminishes apoptotic rate, and increases Vegf-A gene expression and protein distribution in the yolk sac of diabetic rats...
  18. ncbi request reprint Suramin-restricted blood volume in the placenta of normal and diabetic rats is normalized by vitamin E treatment
    P Nash
    Department of Medical Cell Biology, Uppsala University, Biomedicum, Husargatan 3, P O Box 571, SE 751 23 Uppsala, Sweden
    Placenta 28:505-15. 2007
    ..The present work supports the notion that one important effect of untreated maternal diabetes may be impaired placentation, leading to oxidative stress, morphological damage, and compromised placental function...
  19. doi request reprint SOD1 deficiency causes salt sensitivity and aggravates hypertension in hydronephrosis
    Mattias Carlström
    Dept of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Am J Physiol Regul Integr Comp Physiol 297:R82-92. 2009
    ..Increased superoxide formation may enhance TGF response and thereby contribute to hypertension...
  20. ncbi request reprint Placental dysfunction in Suramin-treated rats: impact of maternal diabetes and effects of antioxidative treatment
    Peppi Nash
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    J Soc Gynecol Investig 12:174-84. 2005
    ..The aim of the present study was to evaluate a rat model of placental dysfunction/preeclampsia in pregnancies complicated by maternal diabetes. A second objective was to evaluate the effects of vitamin E treatment in this model...
  21. doi request reprint Nitric oxide deficiency and increased adenosine response of afferent arterioles in hydronephrotic mice with hypertension
    Mattias Carlström
    Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University, Uppsala, Sweden
    Hypertension 51:1386-92. 2008
    ....
  22. ncbi request reprint The paternal allele of the H19 gene is progressively silenced during early mouse development: the acetylation status of histones may be involved in the generation of variegated expression patterns
    K Svensson
    Department of Animal Development and Genetics, Uppsala University, Sweden
    Development 125:61-9. 1998
    ..We suggest that allele-specific silencing of H19 share some common features with chromatin-mediated silencing in position-effect variegation...
  23. ncbi request reprint Increased mRNA levels of Mn-SOD and catalase in embryos of diabetic rats from a malformation-resistant strain
    J Cederberg
    Department of Medical Cell Biology, Uppsala University, Sweden
    Diabetes 49:101-7. 2000
    ..An impaired expression of scavenging enzymes in response to ROS excess can thus be an integral part of a genetic predisposition to embryonic dysmorphogenesis...
  24. doi request reprint Congenital anomalies in diabetic pregnancy
    Ulf J Eriksson
    Department of Medical Cell Biology, Uppsala University, Biomedical Center, PO Box 571, SE 75123 Uppsala, Sweden
    Semin Fetal Neonatal Med 14:85-93. 2009
    ....
  25. ncbi request reprint Maternal diabetes in vivo and high glucose concentration in vitro increases apoptosis in rat embryos
    Mattias Gäreskog
    Department of Medical Cell Biology, Uppsala University, Biomedical Center, PO Box 571, SE 751 23 Uppsala, Sweden
    Reprod Toxicol 23:63-74. 2007
    ..Enhanced apoptotic rate may have a role in diabetic embryopathy by inducing disturbed embryonic maturation, increased rates of resorptions and congenital malformations...
  26. ncbi request reprint Antioxidative treatment diminishes ethanol-induced congenital malformations in the rat
    Parri Wentzel
    Department of Medical Cell Biology, Uppsala universitet, Biomedical Center, Uppsala, Sweden
    Alcohol Clin Exp Res 30:1752-60. 2006
    ....
  27. ncbi request reprint Combined supplementation of folic acid and vitamin E diminishes diabetes-induced embryotoxicity in rats
    Mattias Gäreskog
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Birth Defects Res A Clin Mol Teratol 76:483-90. 2006
    ..Administration of folic acid or vitamin E diminishes embryonic dysmorphogenesis. We aimed to evaluate the effect of combined treatment with folic acid and vitamin E on the disturbed development in embryos of diabetic rats...
  28. doi request reprint Altered gene expression in neural crest cells exposed to ethanol in vitro
    Parri Wentzel
    Department of Medical Cell Biology, Biomedical Center, PO Box 571, SE 75123, Uppsala University, Uppsala, Sweden
    Brain Res 1305:S50-60. 2009
    ..We specifically evaluated expression differences between cNCC and tNCC genes, possibly reflecting the different teratological susceptibilities of the two cell populations...
  29. ncbi request reprint Ethanol-induced fetal dysmorphogenesis in the mouse is diminished by high antioxidative capacity of the mother
    Parri Wentzel
    Department of Medical Cell Biology, Biomedical Center, Uppsala universitet, SE 751 23 Uppsala, Sweden
    Toxicol Sci 92:416-22. 2006
    ..Administration of ethanol to pregnant mice disturbs embryogenesis by oxidative stress, and the adverse effects are more pronounced in offspring of mice with low antioxidative capacity...
  30. ncbi request reprint Folic acid supplementation diminishes diabetes- and glucose-induced dysmorphogenesis in rat embryos in vivo and in vitro
    Parri Wentzel
    Department of Medical Cell Biology, Uppsala University, Biomedical Center, P O Box 571, SE 751 23 Uppsala, Sweden
    Diabetes 54:546-53. 2005
    ..The present work shows that administration of folic acid can diminish diabetes-induced maldevelopment. This suggests that folic acid supplementation may have a role in the prevention of malformations in diabetic pregnancy...
  31. ncbi request reprint Maternal diabetes in vivo and high glucose in vitro diminish GAPDH activity in rat embryos
    Parri Wentzel
    Department of Medical Cell Biology, Biomedical Center, Uppsala University, PO Box 571, SE 751 23 Uppsala, Sweden
    Diabetes 52:1222-8. 2003
    ..In conclusion, dysmorphogenesis caused by maternal diabetes is correlated with ROS-induced inhibition of GAPDH in embryos, which could indicate that inhibition of GAPDH plays a causal role in diabetic embryopathy...
  32. ncbi request reprint 8-Iso-PGF(2alpha) administration generates dysmorphogenesis and increased lipid peroxidation in rat embryos in vitro
    Parri Wentzel
    Department of Medical Cell Biology, Uppsala University, Biomedical Center, Uppsala, Sweden
    Teratology 66:164-8. 2002
    ..e., N-acetylcysteine or superoxide dismutase, to the culture medium...
  33. ncbi request reprint A diabetes-like environment increases malformation rate and diminishes prostaglandin E(2) in rat embryos: reversal by administration of vitamin E and folic acid
    Parri Wentzel
    Department of Medical Cell Biology, Uppsala University, Biomedicum, Uppsala, Sweden
    Birth Defects Res A Clin Mol Teratol 73:506-11. 2005
    ..Furthermore, we studied whether vitamin E and folic acid treatment rectify such alterations...
  34. ncbi request reprint Increase of bikunin and alpha1-microglobulin concentrations in urine of rats during pregnancy is due to decreased tubular reabsorption
    A M Blom
    Department of Medical and Physiological Chemistry, Uppsala, Sweden
    Biochim Biophys Acta 1361:198-202. 1997
    ..These findings imply that the synthesis and the clearance rates of bikunin and alpha1-microglobulin are normal during pregnancy but that the tubular reabsorption of these proteins is decreased...
  35. ncbi request reprint Maternal diabetes in the rat impairs the formation of neural-crest derived cranial nerve ganglia in the offspring
    J Cederberg
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Diabetologia 46:1245-51. 2003
    ..Previous studies have shown changes in fetal organs of neural crest origin in experimental diabetes and changes in migration of neural crest cells exposed to high glucose in vitro...
  36. ncbi request reprint Appearance of glucose-induced insulin release in fetal rat beta-cells
    P Bergsten
    Department of Medical Cell Biology, Uppsala University, Sweden
    J Endocrinol 158:115-20. 1998
    ....
  37. pmc Superoxide dismutase 1 limits renal microvascular remodeling and attenuates arteriole and blood pressure responses to angiotensin II via modulation of nitric oxide bioavailability
    Mattias Carlström
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Hypertension 56:907-13. 2010
    ..This may prevent an early and exaggerated blood pressure response to angiotensin II...
  38. ncbi request reprint Placental dysfunction in Suramin-treated rats--a new model for pre-eclampsia
    P Nash
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Placenta 26:410-8. 2005
    ..The induction of this condition is at least partly mediated by oxidative stress, and is subject to varied genetic susceptibility...
  39. doi request reprint Evidence of increased oxidative stress and a change in the plasminogen activator inhibitor (PAI)-1 to PAI-2 ratio in early-onset but not late-onset preeclampsia
    Anna Karin Wikström
    Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden
    Am J Obstet Gynecol 201:597.e1-8. 2009
    ..The aims of this study were to measure the degree of oxidative stress and alterations in plasminogen activator inhibitor (PAI) type 1 and PAI-2 ratio in women with early-onset and late-onset preeclampsia...
  40. ncbi request reprint Claes Hellerström: a friendly islet explorer
    A Andersson
    Department of Medical Cell Biology, Uppsala University, Sweden
    Diabetologia 50:4 p following 496. 2007
  41. ncbi request reprint Purification, characterization, and biological compartmentalization of rat fetal antigen 1
    H E Carlsson
    Department of Physiology, Division of Comparative Medicine, Section of Medical Biochemistry, Uppsala, Sweden University, 751 23 Uppsala, Sweden
    Biol Reprod 63:30-3. 2000
    ..The highest concentrations were found in fetal serum and amniotic fluid around Day 18 of pregnancy. This is the first report on the physicochemical characteristics and compartmentalization of rat FA1...
  42. pmc Decreased cardiac glutathione peroxidase levels and enhanced mandibular apoptosis in malformed embryos of diabetic rats
    Parri Wentzel
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Diabetes 57:3344-52. 2008
    ..To characterize normal and malformed embryos within the same litters from control and diabetic rats for expression of genes related to metabolism of reactive oxygen species (ROS) or glucose as well as developmental genes...
  43. doi request reprint Genetic influence on dysmorphogenesis in embryos from different rat strains exposed to ethanol in vivo and in vitro
    Parri Wentzel
    Department of Medical Cell Biology, Biomedical Center, Uppsala universitet, Uppsala, Sweden
    Alcohol Clin Exp Res 32:874-87. 2008
    ..The aim was to investigate the susceptibility of embryos from 2 rat strains (U and H) to a 48 hours ethanol exposure in early pregnancy, both in vivo and in vitro...
  44. ncbi request reprint Disturbed morphogenesis of cardiac outflow tract and increased rate of aortic arch anomalies in the offspring of diabetic rats
    Daniel G M Molin
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Birth Defects Res A Clin Mol Teratol 70:927-38. 2004
    ..Hyperglycemia abrogates cardiovascular development in vitro; however, a link to cardiovascular defects in diabetic offspring remains to be investigated...
  45. ncbi request reprint Exposure of neural crest cells to elevated glucose leads to congenital heart defects, an effect that can be prevented by N-acetylcysteine
    Pauline A M Roest
    Department of Anatomy and Embryology, Leiden University Medical Centre, Leiden, The Netherlands
    Birth Defects Res A Clin Mol Teratol 79:231-5. 2007
    ..Antioxidants reduce the damaging effect of glucose on neural crest cells in vitro; therefore, we investigated the effect of supplementing N-acetylcysteine in vivo...