Per Eriksson

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. doi request reprint Neonatal exposure to whole body ionizing radiation induces adult neurobehavioural defects: Critical period, dose-response effects and strain and sex comparison
    Per Eriksson
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 75236 Uppsala, Sweden Electronic address
    Behav Brain Res 304:11-9. 2016
  2. pmc The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation
    Stefan J Kempf
    Institute of Radiation Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Mol Neurodegener 9:57. 2014
  3. ncbi request reprint Polybrominated diphenyl ethers, a group of brominated flame retardants, can interact with polychlorinated biphenyls in enhancing developmental neurobehavioral defects
    Per Eriksson
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Toxicol Sci 94:302-9. 2006
  4. doi request reprint Interaction of gamma-radiation and methyl mercury during a critical phase of neonatal brain development in mice exacerbates developmental neurobehavioural effects
    Per Eriksson
    Department of Environmental Toxicology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18A, Uppsala, Sweden
    Neurotoxicology 31:223-9. 2010
  5. ncbi request reprint Coexposure of neonatal mice to a flame retardant PBDE 99 (2,2',4,4',5-pentabromodiphenyl ether) and methyl mercury enhances developmental neurotoxic defects
    Celia Fischer
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Toxicol Sci 101:275-85. 2008
  6. doi request reprint Neonatal ketamine exposure results in changes in biochemical substrates of neuronal growth and synaptogenesis, and alters adult behavior irreversibly
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Uppsala, Sweden
    Toxicology 249:153-9. 2008
  7. ncbi request reprint Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult mice
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 75236 Uppsala, Sweden
    Toxicol Appl Pharmacol 192:95-106. 2003
  8. doi request reprint Neonatal exposure to propofol affects BDNF but not CaMKII, GAP-43, synaptophysin and tau in the neonatal brain and causes an altered behavioural response to diazepam in the adult mouse brain
    Emma Pontén
    Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Sweden
    Behav Brain Res 223:75-80. 2011
  9. ncbi request reprint Changes in spontaneous behaviour and altered response to nicotine in the adult rat, after neonatal exposure to the brominated flame retardant, decabrominated diphenyl ether (PBDE 209)
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 75236 Uppsala, Sweden
    Neurotoxicology 28:136-42. 2007
  10. ncbi request reprint Neurobehavioral derangements in adult mice receiving decabrominated diphenyl ether (PBDE 209) during a defined period of neonatal brain development
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Norbyvägen, Uppsala, Sweden
    Toxicol Sci 76:112-20. 2003

Collaborators

  • Anders Fredriksson
  • Henrik Viberg
  • Emma Pontén
  • Henrik Alm
  • Eva Jakobsson
  • Rolf Danielsson
  • Johan Eriksson
  • Birger Scholz
  • T Archer
  • Salomon J Sand
  • R Korstanje
  • Xiaosong Wang
  • Kim Kultima
  • E Ankarberg
  • Sonja Buratovic
  • Iwa Lee
  • Celia Fischer
  • Stefan J Kempf
  • Bo Stenerlow
  • Hari S Sharma
  • Anders Hamsten
  • Niclas Johansson
  • Max Bell
  • Malin C Andersen
  • Jacob Odeberg
  • Boris Lenhard
  • Charlotta Dagnell
  • Anne Louise Hemdahl
  • Johannes Hulthe
  • Malin Andersen
  • Giorgis Isaac
  • Per Tornvall
  • Carl Whatling
  • Jacob Lagercrantz
  • Torsten Gordh
  • Simone Moertl
  • Arianna Casciati
  • Sofia Jormsjö
  • Anna Saran
  • Synnöve Sundell-Bergman
  • Aruna Sharma
  • Michael J Atkinson
  • Dirk Janik
  • Marius Ueffing
  • Soile Tapio
  • Simonetta Pazzaglia
  • Frauke Neff
  • Christine von Toerne
  • Ivar Wizelius
  • Hans Stiernström
  • Fredrik Granath
  • Göran Blom
  • Mattias Schindele
  • Carl Johan Wickerts
  • Urban Sicard
  • Claes Roland Martling
  • Karin Olofsson
  • Sten Borgström
  • Per Pedersen
  • Tomas Nolin
  • Johnny Hillgren
  • Lars Ohrn
  • Andreas Hvarfner
  • Johan Berkius
  • Anders Ekbom
  • Erland Löfberg
  • Wyeth W Wasserman
  • Erik Forsberg
  • Anders Enskog
  • Stuart Lithwick
  • Svante Arvidsson
  • Per Hedeström
  • Ola Winsö
  • Per Erik Wärme
  • Hans Blomqvist
  • Lars Mattson
  • David Arenillas
  • Staffan Schon
  • Peter Nordlund
  • Gunnar Lindqvist
  • Pär G Engström
  • Einar Vernersson
  • Robert Svensson
  • Jan Häggqvist
  • Inga Lill Bergsman
  • Svend Höjsgaard
  • Nicholas Wyon
  • C Magnus Skold
  • Johan Grunewald
  • Caroline Olgart Hoglund

Detail Information

Publications40

  1. doi request reprint Neonatal exposure to whole body ionizing radiation induces adult neurobehavioural defects: Critical period, dose-response effects and strain and sex comparison
    Per Eriksson
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 75236 Uppsala, Sweden Electronic address
    Behav Brain Res 304:11-9. 2016
    ..Further studies are needed to investigate mechanisms involved in induction of developmental neurotoxicity following low-dose irradiation. ..
  2. pmc The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation
    Stefan J Kempf
    Institute of Radiation Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Mol Neurodegener 9:57. 2014
    ..The mechanisms underlying such alterations are unknown. We investigated the long-term effects of low doses of total body gamma radiation on neonatally exposed NMRI mice on the molecular and cellular level to elucidate neurodegeneration...
  3. ncbi request reprint Polybrominated diphenyl ethers, a group of brominated flame retardants, can interact with polychlorinated biphenyls in enhancing developmental neurobehavioral defects
    Per Eriksson
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Toxicol Sci 94:302-9. 2006
    ..The neurobehavioral defects were also seen to worsen with age in mice neonatally exposed to PCB 52 + PBDE 99...
  4. doi request reprint Interaction of gamma-radiation and methyl mercury during a critical phase of neonatal brain development in mice exacerbates developmental neurobehavioural effects
    Per Eriksson
    Department of Environmental Toxicology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18A, Uppsala, Sweden
    Neurotoxicology 31:223-9. 2010
    ..The study shows that gamma-radiation and MeHg can interact and significantly exacerbate developmental neurotoxic effects, as manifested by disrupted spontaneous behaviour, lack of habituation, and impaired learning and memory functions...
  5. ncbi request reprint Coexposure of neonatal mice to a flame retardant PBDE 99 (2,2',4,4',5-pentabromodiphenyl ether) and methyl mercury enhances developmental neurotoxic defects
    Celia Fischer
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Toxicol Sci 101:275-85. 2008
    ..This is of vital importance, as the levels of PBDEs are increasing in mother's milk and in the environment generally...
  6. doi request reprint Neonatal ketamine exposure results in changes in biochemical substrates of neuronal growth and synaptogenesis, and alters adult behavior irreversibly
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Uppsala, Sweden
    Toxicology 249:153-9. 2008
    ....
  7. ncbi request reprint Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult mice
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 75236 Uppsala, Sweden
    Toxicol Appl Pharmacol 192:95-106. 2003
    ..The observed developmental neurotoxic effects seen for PBDE 153 are similar to those seen for PBDE 99 and for certain PCBs. Furthermore, PBDEs appear to as potent as the PCBs...
  8. doi request reprint Neonatal exposure to propofol affects BDNF but not CaMKII, GAP-43, synaptophysin and tau in the neonatal brain and causes an altered behavioural response to diazepam in the adult mouse brain
    Emma Pontén
    Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Sweden
    Behav Brain Res 223:75-80. 2011
    ..These changes may be due to neonatal alterations in BDNF levels...
  9. ncbi request reprint Changes in spontaneous behaviour and altered response to nicotine in the adult rat, after neonatal exposure to the brominated flame retardant, decabrominated diphenyl ether (PBDE 209)
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 75236 Uppsala, Sweden
    Neurotoxicology 28:136-42. 2007
    ..It is also clear from the present study and from recent studies from our research group that both lower and higher brominated diphenyl ethers can cause similar developmental neurotoxic effects in both mice and rats...
  10. ncbi request reprint Neurobehavioral derangements in adult mice receiving decabrominated diphenyl ether (PBDE 209) during a defined period of neonatal brain development
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Norbyvägen, Uppsala, Sweden
    Toxicol Sci 76:112-20. 2003
    ..We conclude that more attention should be focused on the highly brominated PBDEs as possible developmental neurotoxic agents...
  11. pmc Proteomic evaluation of neonatal exposure to 2,2 ,4,4 ,5-pentabromodiphenyl ether
    Henrik Alm
    Department of Pharmaceutical Biosciences, Division of Toxicology, Uppsala University, Sweden
    Environ Health Perspect 114:254-9. 2006
    ..This study also shows the usefulness of proteomics to identify potential biomarkers of developmental neurotoxicity of organohalogen compounds...
  12. ncbi request reprint Neonatal exposure to a combination of N-methyl-D-aspartate and gamma-aminobutyric acid type A receptor anesthetic agents potentiates apoptotic neurodegeneration and persistent behavioral deficits
    Anders Fredriksson
    Department of Neuroscience, Psychiatry Ulleraker, Uppsala University, Uppsala, Sweden
    Anesthesiology 107:427-36. 2007
    ..This study examined whether different anesthetic agents, alone and in combination, administered to neonate mice, can trigger apoptosis and whether behavioral deficits occur later in adulthood...
  13. ncbi request reprint Increased susceptibility to adult paraoxon exposure in mice neonatally exposed to nicotine
    Emma Ankarberg
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 752 36, Uppsala, Sweden
    Toxicol Sci 82:555-61. 2004
    ..Animals neonatally exposed to nicotine and exposed to paraoxon as adults showed a deranged spontaneous motor behavior, including hyperactivity and lack of habituation...
  14. ncbi request reprint Investigations of strain and/or gender differences in developmental neurotoxic effects of polybrominated diphenyl ethers in mice
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 75236 Uppsala, Sweden
    Toxicol Sci 81:344-53. 2004
    ..Furthermore, the effects of PBDEs appear to be as potent in female mice as in male mice, and as potent in C57/Bl mice as in NMRI mice, concerning developmental neurotoxicity...
  15. doi request reprint Dose-dependent behavioral disturbances after a single neonatal Bisphenol A dose
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 75236 Uppsala, Sweden
    Toxicology 290:187-94. 2011
    ..The present findings show similarities with effects earlier reported after pre- and perinatal exposure to Bisphenol A, and also with effects seen after a single postnatal exposure to other POPs, such as PBDEs, PCBs and PFCs...
  16. ncbi request reprint Neonatal exposure to the brominated flame retardant 2,2',4,4',5-pentabromodiphenyl ether causes altered susceptibility in the cholinergic transmitter system in the adult mouse
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 75236 Uppsala, Sweden
    Toxicol Sci 67:104-7. 2002
    ..This indicates that PBDE 99 can affect the cholinergic system and might thereby interact with other environmental toxicants...
  17. ncbi request reprint Neonatal co-exposure to low doses of an ortho-PCB (PCB 153) and methyl mercury exacerbate defective developmental neurobehavior in mice
    Celia Fischer
    Department of Environmental Toxicology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Toxicology 244:157-65. 2008
    ..These effects are manifested as disrupted spontaneous behavior, lack of habituation, and reduced cognitive functions. These effects occur at doses within the same order of magnitude as reported for exposed children...
  18. doi request reprint Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brain
    Niclas Johansson
    Department of Environmental Toxicology, Uppsala University, Uppsala, Sweden
    Toxicol Sci 108:412-8. 2009
    ..These proteins are important for normal brain development, and altered levels of these proteins during a critical period of the brain growth spurts could be one of the mechanisms behind earlier reported behavioral defects...
  19. ncbi request reprint Neonatal exposure to higher brominated diphenyl ethers, hepta-, octa-, or nonabromodiphenyl ether, impairs spontaneous behavior and learning and memory functions of adult mice
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Toxicol Sci 92:211-8. 2006
    ..It is important to consider the fact that different PBDE congeners can have differing degrees of potency, when comparing levels of PBDEs in the environment and in mother's milk...
  20. ncbi request reprint Neonatal exposure to decabrominated diphenyl ether (PBDE 209) results in changes in BDNF, CaMKII and GAP-43, biochemical substrates of neuronal survival, growth, and synaptogenesis
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 75236 Uppsala, Sweden
    Neurotoxicology 29:152-9. 2008
    ..This shows that PBDE 209 affects important proteins involved in normal maturation of the brain and further strengthen our findings concerning PBDE 209 as a developmental neurotoxicological agent...
  21. doi request reprint Neonatal exposure to a moderate dose of ionizing radiation causes behavioural defects and altered levels of tau protein in mice
    Sonja Buratovic
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 75236 Uppsala, Sweden Electronic address
    Neurotoxicology 45:48-55. 2014
    ..Moreover, an elevation of tau protein was observed in male mice displaying reduced cognitive function...
  22. doi request reprint Adult dose-dependent behavioral and cognitive disturbances after a single neonatal PFHxS dose
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 75236 Uppsala, Sweden
    Toxicology 304:185-91. 2013
    ....
  23. doi request reprint Differences in neonatal neurotoxicity of brominated flame retardants, PBDE 99 and TBBPA, in mice
    Henrik Viberg
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, Uppsala, Sweden
    Toxicology 289:59-65. 2011
    ....
  24. ncbi request reprint Neurofunctional deficits and potentiated apoptosis by neonatal NMDA antagonist administration
    Anders Fredriksson
    Department of Neuroscience, Psychiatry Ulleraker, Uppsala University, SE 750 17 Uppsala, Sweden
    Behav Brain Res 153:367-76. 2004
    ..The potentiated apoptosis induced by ketamine and diazepam may have implications for the selection of drugs used in neonatal paediatric anaesthesia...
  25. doi request reprint Developmental neurotoxic effects of two pesticides: Behavior and biomolecular studies on chlorpyrifos and carbaryl
    Iwa Lee
    Dept of Environmental Toxicology, Uppsala University, Uppsala, Sweden
    Toxicol Appl Pharmacol 288:429-38. 2015
    ....
  26. doi request reprint Developmental neurotoxic effects of two pesticides: Behavior and neuroprotein studies on endosulfan and cypermethrin
    Iwa Lee
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 75236 Uppsala, Sweden
    Toxicology 335:1-10. 2015
    ..Also, the present study suggests a possible link between the altered levels of neuroprotein and changes in behavior when exposed during a critical period of brain development...
  27. doi request reprint Developmental exposure to the polybrominated diphenyl ether PBDE 209: Neurobehavioural and neuroprotein analysis in adult male and female mice
    Sonja Buratovic
    Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 75236 Uppsala, Sweden
    Environ Toxicol Pharmacol 38:570-85. 2014
    ..The behavioural defects were dose-response related and persistent. In mice of both sexes and showing behavioural defects, neuroprotein tau was increased. ..
  28. ncbi request reprint Propofol promotes blood-brain barrier breakdown and heat shock protein (HSP 72 kd) activation in the developing mouse brain
    Hari S Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75421, Uppsala, Sweden
    CNS Neurol Disord Drug Targets 13:1595-603. 2014
    ..These novel observations suggest that anesthetic agents, by inducing cellular stress in the developing brain may disrupt the BBB permeability that may have long lasting effects on adult brain function. ..
  29. ncbi request reprint Brain lipid composition in postnatal iron-induced motor behavior alterations following chronic neuroleptic administration in mice
    Giorgis Isaac
    Department of Analytical Chemistry, Biomedical Center, Uppsala University, Sweden
    FEBS J 273:2232-43. 2006
    ..In conclusion our results support the hypothesis that an association between psychiatric disorders and lipid and behavior abnormalities in the brain exists...
  30. ncbi request reprint Dose-response modeling and benchmark calculations from spontaneous behavior data on mice neonatally exposed to 2,2',4,4',5-pentabromodiphenyl ether
    Salomon Sand
    Institute of Environmental Medicine, Karolinska Institutet, P O Box 210, 17177 Stockholm, Sweden
    Toxicol Sci 81:491-501. 2004
    ..Using this methodology, the BMD was defined as corresponding to an excess risk of 5 or 10% of falling below cutoff points representing adverse levels of fractional response...
  31. ncbi request reprint Locating Ath8, a locus for murine atherosclerosis susceptibility and testing several of its candidate genes in mice and humans
    Ron Korstanje
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Atherosclerosis 177:443-50. 2004
    ..We found a significant association between ANGPTL3 and atherosclerotic lesions (P < 0.05) in human. These results suggest that Angptl3 is involved in atherosclerosis susceptibility in both mouse and human...
  32. pmc Alternative promoter usage of the membrane glycoprotein CD36
    Malin Andersen
    Department of Biotechnology, AlbaNova University Center, Royal Institute of Technology KTH, 106 91 Stockholm, Sweden
    BMC Mol Biol 7:8. 2006
    ..We have investigated the expression patterns of five alternative first exons of the CD36 gene in several human tissues and cell types, to better understand the molecular details behind its regulation...
  33. ncbi request reprint Plasma interleukin (IL)-18 concentrations is elevated in patients with previous myocardial infarction and related to severity of coronary atherosclerosis independently of C-reactive protein and IL-6
    Johannes Hulthe
    Discovery Medicine, AstraZeneca, Molndal, Sweden Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Gothenburg, Sweden
    Atherosclerosis 188:450-4. 2006
    ..Furthermore, the relationships between plasma IL-18 concentrations and coronary atherosclerosis, C-reactive protein (CRP), interleukin-6 (IL-6) and traditional cardiovascular risk factors were examined...
  34. pmc Differential expression of cysteine and aspartic proteases during progression of atherosclerosis in apolipoprotein E-deficient mice
    Sofia Jormsjö
    Atherosclerosis Research Unit, Karolinska Hospital, Stockholm, Sweden
    Am J Pathol 161:939-45. 2002
    ..In conclusion, increased expression of several cathepsins in atherosclerotic lesions suggests that these proteases may participate in the remodeling of extracellular matrix associated with the atherosclerotic process...
  35. ncbi request reprint Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction
    Anne Louise Hemdahl
    Center for Molecular Medicine, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 26:136-42. 2006
    ..This study aimed to analyze the expression of NGAL in atherosclerotic plaques and myocardial infarction (MI)...
  36. pmc In silico detection of sequence variations modifying transcriptional regulation
    Malin C Andersen
    Department of Gene Technology, School of Biotechnology, AlbaNova University Center, Royal Institute of Technology KTH, Stockholm, Sweden
    PLoS Comput Biol 4:e5. 2008
    ..The RAVEN system is available at http://www.cisreg.ca for all researchers interested in the detection and characterization of regulatory sequence variation...
  37. ncbi request reprint Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility
    Xiaosong Wang
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Genet 37:365-72. 2005
    ..05) in individuals with myocardial infarction than in controls. We therefore conclude that Tnfsf4 underlies Ath1 in mice and that polymorphisms in its human homolog TNFSF4 increase the risk of myocardial infarction in humans...
  38. doi request reprint End-stage renal disease patients on renal replacement therapy in the intensive care unit: short- and long-term outcome
    Max Bell
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Crit Care Med 36:2773-8. 2008
    ..We aimed to describe the short- and long-term outcome of these patients after renal replacement therapy in the intensive care unit...
  39. ncbi request reprint No evidence that the PLA1/PLA2 polymorphism of platelet glycoprotein IIIa is implicated in angiographically characterized coronary atherosclerosis and premature myocardial infarction
    Jacob Lagercrantz
    Department of Medicine, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Blood Coagul Fibrinolysis 14:749-53. 2003
    ....
  40. ncbi request reprint Effects of neurotrophins on human bronchial smooth muscle cell migration and matrix metalloproteinase-9 secretion
    Charlotta Dagnell
    Department of Medicine Solna, Division of Respiratory Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Transl Res 150:303-10. 2007
    ..BDNF and NT-3, but not NGF, stimulated HBSMC migration as evaluated by Boyden chamber. Taken together, our data indicate that the neurotrophins may stimulate events important for airway remodeling...