Research Topics
| Per ErikssonSummaryAffiliation: Uppsala University Country: Sweden Publications
| Collaborators
|
Detail Information
Publications
Interaction of gamma-radiation and methyl mercury during a critical phase of neonatal brain development in mice exacerbates developmental neurobehavioural effectsPer Eriksson
Department of Environmental Toxicology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18A, Uppsala, Sweden
Neurotoxicology 31:223-9. 2010..The study shows that gamma-radiation and MeHg can interact and significantly exacerbate developmental neurotoxic effects, as manifested by disrupted spontaneous behaviour, lack of habituation, and impaired learning and memory functions...
Polybrominated diphenyl ethers, a group of brominated flame retardants, can interact with polychlorinated biphenyls in enhancing developmental neurobehavioral defectsPer Eriksson
Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
Toxicol Sci 94:302-9. 2006..The neurobehavioral defects were also seen to worsen with age in mice neonatally exposed to PCB 52 + PBDE 99...- Coexposure of neonatal mice to a flame retardant PBDE 99 (2,2',4,4',5-pentabromodiphenyl ether) and methyl mercury enhances developmental neurotoxic defectsCelia Fischer
Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
Toxicol Sci 101:275-85. 2008..This is of vital importance, as the levels of PBDEs are increasing in mother's milk and in the environment generally... - Neonatal ketamine exposure results in changes in biochemical substrates of neuronal growth and synaptogenesis, and alters adult behavior irreversiblyHenrik Viberg
Department of Environmental Toxicology, Uppsala University, Uppsala, Sweden
Toxicology 249:153-9. 2008.... - Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult miceHenrik Viberg
Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 75236 Uppsala, Sweden
Toxicol Appl Pharmacol 192:95-106. 2003..The observed developmental neurotoxic effects seen for PBDE 153 are similar to those seen for PBDE 99 and for certain PCBs. Furthermore, PBDEs appear to as potent as the PCBs... - Neonatal exposure to propofol affects BDNF but not CaMKII, GAP-43, synaptophysin and tau in the neonatal brain and causes an altered behavioural response to diazepam in the adult mouse brainEmma Pontén
Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Sweden
Behav Brain Res 223:75-80. 2011..These changes may be due to neonatal alterations in BDNF levels... - Changes in spontaneous behaviour and altered response to nicotine in the adult rat, after neonatal exposure to the brominated flame retardant, decabrominated diphenyl ether (PBDE 209)Henrik Viberg
Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 75236 Uppsala, Sweden
Neurotoxicology 28:136-42. 2007..It is also clear from the present study and from recent studies from our research group that both lower and higher brominated diphenyl ethers can cause similar developmental neurotoxic effects in both mice and rats... - Neurobehavioral derangements in adult mice receiving decabrominated diphenyl ether (PBDE 209) during a defined period of neonatal brain developmentHenrik Viberg
Department of Environmental Toxicology, Uppsala University, Norbyvägen, Uppsala, Sweden
Toxicol Sci 76:112-20. 2003..We conclude that more attention should be focused on the highly brominated PBDEs as possible developmental neurotoxic agents... 
Proteomic evaluation of neonatal exposure to 2,2 ,4,4 ,5-pentabromodiphenyl etherHenrik Alm
Department of Pharmaceutical Biosciences, Division of Toxicology, Uppsala University, Sweden
Environ Health Perspect 114:254-9. 2006..This study also shows the usefulness of proteomics to identify potential biomarkers of developmental neurotoxicity of organohalogen compounds...- Investigations of strain and/or gender differences in developmental neurotoxic effects of polybrominated diphenyl ethers in miceHenrik Viberg
Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 75236 Uppsala, Sweden
Toxicol Sci 81:344-53. 2004..Furthermore, the effects of PBDEs appear to be as potent in female mice as in male mice, and as potent in C57/Bl mice as in NMRI mice, concerning developmental neurotoxicity... - Increased susceptibility to adult paraoxon exposure in mice neonatally exposed to nicotineEmma Ankarberg
Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 752 36, Uppsala, Sweden
Toxicol Sci 82:555-61. 2004..Animals neonatally exposed to nicotine and exposed to paraoxon as adults showed a deranged spontaneous motor behavior, including hyperactivity and lack of habituation... - Neonatal exposure to a combination of N-methyl-D-aspartate and gamma-aminobutyric acid type A receptor anesthetic agents potentiates apoptotic neurodegeneration and persistent behavioral deficitsAnders Fredriksson
Department of Neuroscience, Psychiatry Ulleraker, Uppsala University, Uppsala, Sweden
Anesthesiology 107:427-36. 2007..This study examined whether different anesthetic agents, alone and in combination, administered to neonate mice, can trigger apoptosis and whether behavioral deficits occur later in adulthood... - Neonatal co-exposure to low doses of an ortho-PCB (PCB 153) and methyl mercury exacerbate defective developmental neurobehavior in miceCelia Fischer
Department of Environmental Toxicology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
Toxicology 244:157-65. 2008..These effects are manifested as disrupted spontaneous behavior, lack of habituation, and reduced cognitive functions. These effects occur at doses within the same order of magnitude as reported for exposed children... - Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brainNiclas Johansson
Department of Environmental Toxicology, Uppsala University, Uppsala, Sweden
Toxicol Sci 108:412-8. 2009..These proteins are important for normal brain development, and altered levels of these proteins during a critical period of the brain growth spurts could be one of the mechanisms behind earlier reported behavioral defects... - Neonatal exposure to the brominated flame retardant 2,2',4,4',5-pentabromodiphenyl ether causes altered susceptibility in the cholinergic transmitter system in the adult mouseHenrik Viberg
Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 75236 Uppsala, Sweden
Toxicol Sci 67:104-7. 2002..This indicates that PBDE 99 can affect the cholinergic system and might thereby interact with other environmental toxicants... - Dose-dependent behavioral disturbances after a single neonatal Bisphenol A doseHenrik Viberg
Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 75236 Uppsala, Sweden
Toxicology 290:187-94. 2011..The present findings show similarities with effects earlier reported after pre- and perinatal exposure to Bisphenol A, and also with effects seen after a single postnatal exposure to other POPs, such as PBDEs, PCBs and PFCs... - Neonatal exposure to decabrominated diphenyl ether (PBDE 209) results in changes in BDNF, CaMKII and GAP-43, biochemical substrates of neuronal survival, growth, and synaptogenesisHenrik Viberg
Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S 75236 Uppsala, Sweden
Neurotoxicology 29:152-9. 2008..This shows that PBDE 209 affects important proteins involved in normal maturation of the brain and further strengthen our findings concerning PBDE 209 as a developmental neurotoxicological agent... - Neonatal exposure to higher brominated diphenyl ethers, hepta-, octa-, or nonabromodiphenyl ether, impairs spontaneous behavior and learning and memory functions of adult miceHenrik Viberg
Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, S-752 36 Uppsala, Sweden
Toxicol Sci 92:211-8. 2006..It is important to consider the fact that different PBDE congeners can have differing degrees of potency, when comparing levels of PBDEs in the environment and in mother's milk... - Neurofunctional deficits and potentiated apoptosis by neonatal NMDA antagonist administrationAnders Fredriksson
Department of Neuroscience, Psychiatry Ulleraker, Uppsala University, SE 750 17 Uppsala, Sweden
Behav Brain Res 153:367-76. 2004..The potentiated apoptosis induced by ketamine and diazepam may have implications for the selection of drugs used in neonatal paediatric anaesthesia... - Differences in neonatal neurotoxicity of brominated flame retardants, PBDE 99 and TBBPA, in miceHenrik Viberg
Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, Uppsala, Sweden
Toxicology 289:59-65. 2011.... - Brain lipid composition in postnatal iron-induced motor behavior alterations following chronic neuroleptic administration in miceGiorgis Isaac
Department of Analytical Chemistry, Biomedical Center, Uppsala University, Sweden
FEBS J 273:2232-43. 2006..In conclusion our results support the hypothesis that an association between psychiatric disorders and lipid and behavior abnormalities in the brain exists... - Adult dose-dependent behavioral and cognitive disturbances after a single neonatal PFHxS doseHenrik Viberg
Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 75236 Uppsala, Sweden
Toxicology 304:185-91. 2013.... - Dose-response modeling and benchmark calculations from spontaneous behavior data on mice neonatally exposed to 2,2',4,4',5-pentabromodiphenyl etherSalomon Sand
Institute of Environmental Medicine, Karolinska Institutet, P O Box 210, 17177 Stockholm, Sweden
Toxicol Sci 81:491-501. 2004..Using this methodology, the BMD was defined as corresponding to an excess risk of 5 or 10% of falling below cutoff points representing adverse levels of fractional response... - Differential expression of cysteine and aspartic proteases during progression of atherosclerosis in apolipoprotein E-deficient miceSofia Jormsjö
Atherosclerosis Research Unit, Karolinska Hospital, Stockholm, Sweden
Am J Pathol 161:939-45. 2002..In conclusion, increased expression of several cathepsins in atherosclerotic lesions suggests that these proteases may participate in the remodeling of extracellular matrix associated with the atherosclerotic process... - No evidence that the PLA1/PLA2 polymorphism of platelet glycoprotein IIIa is implicated in angiographically characterized coronary atherosclerosis and premature myocardial infarctionJacob Lagercrantz
Department of Medicine, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
Blood Coagul Fibrinolysis 14:749-53. 2003.... - Locating Ath8, a locus for murine atherosclerosis susceptibility and testing several of its candidate genes in mice and humansRon Korstanje
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
Atherosclerosis 177:443-50. 2004..We found a significant association between ANGPTL3 and atherosclerotic lesions (P < 0.05) in human. These results suggest that Angptl3 is involved in atherosclerosis susceptibility in both mouse and human... - Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibilityXiaosong Wang
The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
Nat Genet 37:365-72. 2005..05) in individuals with myocardial infarction than in controls. We therefore conclude that Tnfsf4 underlies Ath1 in mice and that polymorphisms in its human homolog TNFSF4 increase the risk of myocardial infarction in humans... - End-stage renal disease patients on renal replacement therapy in the intensive care unit: short- and long-term outcomeMax Bell
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Crit Care Med 36:2773-8. 2008..We aimed to describe the short- and long-term outcome of these patients after renal replacement therapy in the intensive care unit... - Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarctionAnne Louise Hemdahl
Center for Molecular Medicine, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
Arterioscler Thromb Vasc Biol 26:136-42. 2006..This study aimed to analyze the expression of NGAL in atherosclerotic plaques and myocardial infarction (MI)... - In silico detection of sequence variations modifying transcriptional regulationMalin C Andersen
Department of Gene Technology, School of Biotechnology, AlbaNova University Center, Royal Institute of Technology KTH, Stockholm, Sweden
PLoS Comput Biol 4:e5. 2008..The RAVEN system is available at http://www.cisreg.ca for all researchers interested in the detection and characterization of regulatory sequence variation... - Plasma interleukin (IL)-18 concentrations is elevated in patients with previous myocardial infarction and related to severity of coronary atherosclerosis independently of C-reactive protein and IL-6Johannes Hulthe
Discovery Medicine, AstraZeneca, Molndal, Sweden Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Gothenburg, Sweden
Atherosclerosis 188:450-4. 2006..Furthermore, the relationships between plasma IL-18 concentrations and coronary atherosclerosis, C-reactive protein (CRP), interleukin-6 (IL-6) and traditional cardiovascular risk factors were examined... - Alternative promoter usage of the membrane glycoprotein CD36Malin Andersen
Department of Biotechnology, AlbaNova University Center, Royal Institute of Technology KTH, 106 91 Stockholm, Sweden
BMC Mol Biol 7:8. 2006..We have investigated the expression patterns of five alternative first exons of the CD36 gene in several human tissues and cell types, to better understand the molecular details behind its regulation... - Effects of neurotrophins on human bronchial smooth muscle cell migration and matrix metalloproteinase-9 secretionCharlotta Dagnell
Department of Medicine Solna, Division of Respiratory Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
Transl Res 150:303-10. 2007..BDNF and NT-3, but not NGF, stimulated HBSMC migration as evaluated by Boyden chamber. Taken together, our data indicate that the neurotrophins may stimulate events important for airway remodeling...