H Ellegren

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. pmc The recombination landscape of the zebra finch Taeniopygia guttata genome
    Niclas Backstrom
    Department of Evolutionary Biology, Uppsala University, SE 752 36 Uppsala, Sweden
    Genome Res 20:485-95. 2010
  2. pmc Molecular evolution of genes in avian genomes
    Kiwoong Nam
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, Uppsala, S 752 36, Sweden
    Genome Biol 11:R68. 2010
  3. pmc Inferring the demographic history of European Ficedula flycatcher populations
    Niclas Backstrom
    Department of Evolutionary Biology, Evolutionary Biology Centre EBC, Uppsala University, Norbyvagen 18D, Uppsala, SE 752 36, Sweden
    BMC Evol Biol 13:2. 2013
  4. pmc Genome-wide analysis in chicken reveals that local levels of genetic diversity are mainly governed by the rate of recombination
    Carina F Mugal
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36, Uppsala, Sweden
    BMC Genomics 14:86. 2013
  5. pmc The unique genomic properties of sex-biased genes: insights from avian microarray data
    Judith E Mank
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    BMC Genomics 9:148. 2008
  6. pmc Insertion-deletion polymorphisms (indels) as genetic markers in natural populations
    Ulo Väli
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    BMC Genet 9:8. 2008
  7. ncbi request reprint Sex-specific mutation rates in salmonid fish
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36, Uppsala, Sweden
    J Mol Evol 56:458-63. 2003
  8. pmc The chicken (Gallus gallus) Z chromosome contains at least three nonlinear evolutionary strata
    Kiwoong Nam
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, SE 752 36 Uppsala, Sweden
    Genetics 180:1131-6. 2008
  9. pmc Genomic evidence for a large-Z effect
    Hans Ellegren
    Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, 752 36 Uppsala, Sweden
    Proc Biol Sci 276:361-6. 2009
  10. ncbi request reprint Levels of polymorphism on the sex-limited chromosome: a clue to Y from W?
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Bioessays 25:163-7. 2003

Detail Information

Publications101 found, 100 shown here

  1. pmc The recombination landscape of the zebra finch Taeniopygia guttata genome
    Niclas Backstrom
    Department of Evolutionary Biology, Uppsala University, SE 752 36 Uppsala, Sweden
    Genome Res 20:485-95. 2010
    ..Levels of linkage disequilibrium (LD) were significantly higher in regions of low recombination, showing that heterogeneity in recombination rates have left a footprint on the genomic landscape of LD in zebra finch populations...
  2. pmc Molecular evolution of genes in avian genomes
    Kiwoong Nam
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, Uppsala, S 752 36, Sweden
    Genome Biol 11:R68. 2010
    ....
  3. pmc Inferring the demographic history of European Ficedula flycatcher populations
    Niclas Backstrom
    Department of Evolutionary Biology, Evolutionary Biology Centre EBC, Uppsala University, Norbyvagen 18D, Uppsala, SE 752 36, Sweden
    BMC Evol Biol 13:2. 2013
    ..Here we use data from 24 intronic loci re-sequenced in population samples of two closely related species, the pied flycatcher and the collared flycatcher...
  4. pmc Genome-wide analysis in chicken reveals that local levels of genetic diversity are mainly governed by the rate of recombination
    Carina F Mugal
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36, Uppsala, Sweden
    BMC Genomics 14:86. 2013
    ..Moreover, recombination might itself be mutagenic and thereby assert a direct effect on diversity levels...
  5. pmc The unique genomic properties of sex-biased genes: insights from avian microarray data
    Judith E Mank
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    BMC Genomics 9:148. 2008
    ..In order to develop a framework for the analysis of sex-biased genes, we present a characterization of microarray data comparing male and female gene expression in 18 day chicken embryos for brain, gonad, and heart tissue...
  6. pmc Insertion-deletion polymorphisms (indels) as genetic markers in natural populations
    Ulo Väli
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    BMC Genet 9:8. 2008
    ..We introduce the use of short insertion-deletion polymorphisms (indels) for genetic analysis of natural populations...
  7. ncbi request reprint Sex-specific mutation rates in salmonid fish
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36, Uppsala, Sweden
    J Mol Evol 56:458-63. 2003
    ..This would suggest that replication errors play a major role for the generation of new mutations...
  8. pmc The chicken (Gallus gallus) Z chromosome contains at least three nonlinear evolutionary strata
    Kiwoong Nam
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, SE 752 36 Uppsala, Sweden
    Genetics 180:1131-6. 2008
    ..These observations suggest that the progressive restriction of recombination is an integral feature of sex chromosome evolution and occurs also in systems of female heterogamety...
  9. pmc Genomic evidence for a large-Z effect
    Hans Ellegren
    Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, 752 36 Uppsala, Sweden
    Proc Biol Sci 276:361-6. 2009
    ..This points at a genomic 'large-Z effect', which is widespread and of general significance for adaptive divergence in birds...
  10. ncbi request reprint Levels of polymorphism on the sex-limited chromosome: a clue to Y from W?
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Bioessays 25:163-7. 2003
    ....
  11. doi request reprint Comparative genomics and the study of evolution by natural selection
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Mol Ecol 17:4586-96. 2008
    ..Finally, genome sequencing using outbred or multiple individuals has provided a wealth of polymorphism data that gives information on population history, demography and marker evolution...
  12. pmc Is genetic diversity really higher in large populations?
    Hans Ellegren
    Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    J Biol 8:41. 2009
    ..A recent study in BMC Evolutionary Biology shows that variation in the rate of mutation rather than in population size is the main explanation for variations in mtDNA diversity observed among bird species...
  13. pmc Characteristics, causes and evolutionary consequences of male-biased mutation
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, 752 36 Uppsala, Sweden
    Proc Biol Sci 274:1-10. 2007
    ....
  14. doi request reprint Sex chromosomes: platypus genome suggests a recent origin for the human X
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Curr Biol 18:R557-9. 2008
    ..The unusual sex chromosomes of platypus are not homologous to the human X and Y chromosomes, implying that the sex chromosomes of placental mammals evolved after the monotreme and placental mammal lineages split about 165 million years ago...
  15. doi request reprint Genetic basis of fitness differences in natural populations
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Nature 452:169-75. 2008
    ..In parallel, an emerging understanding of the quantitative genetics of fitness variation in the wild means that we are poised to see a synthesis of ecological and molecular approaches in evolutionary biology...
  16. ncbi request reprint Mutation rate variation in the mammalian genome
    Hans Ellegren
    Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Curr Opin Genet Dev 13:562-8. 2003
    ..An important aspect for further research in this area is to study whether there is an ultimate evolutionary explanation for mutation rate variation within mammalian genomes...
  17. ncbi request reprint Microsatellites: simple sequences with complex evolution
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Nat Rev Genet 5:435-45. 2004
  18. pmc Faced with inequality: chicken do not have a general dosage compensation of sex-linked genes
    Hans Ellegren
    Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    BMC Biol 5:40. 2007
    ..While otherwise widespread in systems with heteromorphic sex chromosomes, the case of dosage compensation in birds (males ZZ, females ZW) remains an unsolved enigma...
  19. ncbi request reprint The evolution of sex-biased genes and sex-biased gene expression
    Hans Ellegren
    Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Nat Rev Genet 8:689-98. 2007
    ..Sex-biased gene expression has implications beyond just evolutionary biology, including for medical genetics...
  20. ncbi request reprint Molecular evolutionary genomics of birds
    H Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Cytogenet Genome Res 117:120-30. 2007
    ....
  21. ncbi request reprint Evolutionary genomics: a dinosaur's view of genome-size evolution
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Curr Biol 17:R470-2. 2007
    ..This suggests that birds' small genomes are not an adaptation to metabolic demands associated with flight...
  22. doi request reprint Sex determination: two copies for one cock
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Curr Biol 19:R909-10. 2009
    ..Genetically male chicken embryos, which have two Z sex chromosomes, develop female gonads when the Z chromosome-linked gene DMRT1 is knocked out. This suggests that sex is determined by Z chromosome dosage...
  23. pmc Hens, cocks and avian sex determination. A quest for genes on Z or W?
    H Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    EMBO Rep 2:192-6. 2001
    ..Clearly defining the roles of the DMRT1 and PKC1W genes in gonadal development, and ultimately determining whether avian sex is dependent on Z or W, will require transgenic experiments...
  24. doi request reprint Evolutionary stasis: the stable chromosomes of birds
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Norbyvagen 18D, SE 75236 Uppsala, Sweden
    Trends Ecol Evol 25:283-91. 2010
    ....
  25. doi request reprint Sequencing goes 454 and takes large-scale genomics into the wild
    Hans Ellegren
    Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, SE 75236 Uppsala, Sweden
    Mol Ecol 17:1629-31. 2008
    ..Using this new technology, the protein-coding sequences of the Glanville fritillary butterfly genome have now been largely characterized...
  26. doi request reprint Sex-chromosome evolution: recent progress and the influence of male and female heterogamety
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvgen 18D, SE752 36 Uppsala, Sweden
    Nat Rev Genet 12:157-66. 2011
    ..Therefore, I discuss how patterns and processes associated with sex linkage in male- and female-heterogametic systems offer a useful contrast in the study of sex-chromosome evolution...
  27. ncbi request reprint Dosage compensation: do birds do it as well?
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Trends Genet 18:25-8. 2002
    ..A recently identified hypermethylated region on the Z chromosome, with similarities to the X inactivation centre on the mammalian X chromosome, might play a part in this process or have a role in avian sex determination...
  28. pmc Multiple and independent cessation of recombination between avian sex chromosomes
    H Ellegren
    Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, SE 752 36 SE 752 36 Uppsala, Sweden
    Genetics 158:325-31. 2001
    ..Our data demonstrate that this process, once initiated, may occur independently in parallel in sister lineages...
  29. pmc Substitution rate variation at human CpG sites correlates with non-CpG divergence, methylation level and GC content
    Carina F Mugal
    Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, Uppsala, Sweden
    Genome Biol 12:R58. 2011
    ....
  30. doi request reprint The different levels of genetic diversity in sex chromosomes and autosomes
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Trends Genet 25:278-84. 2009
    ....
  31. ncbi request reprint Microsatellite mutations in the germline: implications for evolutionary inference
    H Ellegren
    Dept of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36, Uppsala, Sweden
    Trends Genet 16:551-8. 2000
    ..Within genomes at equilibrium, the microsatellite-length distribution is a delicate balance between biased mutation processes and point mutations acting towards the decay of repetitive DNA. Indeed, simple repeats do not evolve simply...
  32. pmc Emergence of male-biased genes on the chicken Z-chromosome: sex-chromosome contrasts between male and female heterogametic systems
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Genome Res 21:2082-6. 2011
    ..This is consistent with theoretical models on the evolution of sexually antagonistic genes in which new mutations are at least partly dominant...
  33. ncbi request reprint Widespread origins of domestic horse lineages
    C Vila
    Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, S 75236 Uppsala, Sweden
    Science 291:474-7. 2001
    ..However, genetic variation at nuclear markers is partitioned among horse breeds and may reflect sex-biased dispersal and breeding...
  34. ncbi request reprint Male-driven evolution of DNA sequences in birds
    H Ellegren
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Nat Genet 17:182-4. 1997
    ..9-6.5. Thus, evolution appears to be male driven in birds--a situation that supports a neutral model of molecular evolution...
  35. ncbi request reprint Speciation, introgressive hybridization and nonlinear rate of molecular evolution in flycatchers
    G P Saetre
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Mol Ecol 10:737-49. 2001
    ..After the last glaciation period, pied and collared flycatchers expanded their breeding ranges and eventually came into secondary contact in Central and Eastern Europe and on the Baltic Isles...
  36. pmc Unequal contribution of sexes in the origin of dog breeds
    A K Sundqvist
    Department of Evolutionary Biology, Uppsala University, Sweden
    Genetics 172:1121-8. 2006
    ..This demonstrates a lower exchange of males than of females between breeds belonging to different groups, which illustrates how breed founders may have been chosen...
  37. pmc Molecular evolution of the avian CHD1 genes on the Z and W sex chromosomes
    A K Fridolfsson
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, SE 752 36 Uppsala, Sweden
    Genetics 155:1903-12. 2000
    ..Our data are compatible with a male-biased mutation rate, manifested by the faster rate of neutral evolution (synonymous substitutions) on the Z chromosome than on the female-specific W chromosome...
  38. ncbi request reprint SNPs in ecological and conservation studies: a test in the Scandinavian wolf population
    J M Seddon
    Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, SE 752 36, Uppsala, Sweden
    Mol Ecol 14:503-11. 2005
    ..Furthermore, the ability to amplify extremely small fragments makes SNPs of particular use for population monitoring, where faecal and other noninvasive samples are routinely used...
  39. ncbi request reprint Contrasting levels of nucleotide diversity on the avian Z and W sex chromosomes
    H Montell
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 18:2010-6. 2001
    ....
  40. pmc A temporal analysis shows major histocompatibility complex loci in the Scandinavian wolf population are consistent with neutral evolution
    J M Seddon
    Department of Evolutionary Biology, EBC, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Proc Biol Sci 271:2283-91. 2004
    ..Even in these larger populations, bottlenecks and fragmentation with consequent genetic drift are likely to have resulted in few indicators for balancing selection and significant differentiation of populations...
  41. pmc Evolutionary strata on the chicken Z chromosome: implications for sex chromosome evolution
    Lori Jayne Lawson Handley
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, SE 752 36 Uppsala, Sweden
    Genetics 167:367-76. 2004
    ..Our data suggest that progressive and stepwise cessation of recombination is a general feature behind sex chromosome evolution...
  42. pmc Reduced variation on the chicken Z chromosome
    Hannah Sundström
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, SE 752 36 Uppsala, Sweden
    Genetics 167:377-85. 2004
    ....
  43. ncbi request reprint Two centuries of the Scandinavian wolf population: patterns of genetic variability and migration during an era of dramatic decline
    Ø Flagstad
    Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, S 752 36 Uppsala, Sweden
    Mol Ecol 12:869-80. 2003
    ..After 1940, however, there is evidence of several immigration events, coinciding with episodes of marked population increase in Russian Karelia and subsequent westwards migration...
  44. ncbi request reprint Genetic variation and population structure in Scandinavian wolverine (Gulo gulo) populations
    C W Walker
    Department of Evolutionary Biology, Uppsala University, , S-752 36 Uppsala, Sweden
    Mol Ecol 10:53-63. 2001
    ..The observed subdivision between populations calls for management caution when issuing harvest quotas, especially for the geographically isolated south Norwegian population...
  45. ncbi request reprint Heterogeneous mutation processes in human microsatellite DNA sequences
    H Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Nat Genet 24:400-2. 2000
    ..An excess of paternally transmitted mutations (male-to-female ratio of 4.9) supports a male-biased mutation rate in the human genome...
  46. ncbi request reprint Mapping of 13 horse genes by fluorescence in-situ hybridization (FISH) and somatic cell hybrid analysis
    G Lindgren
    Department of Evolutionary Biology, Norbyvägen, Uppsala University, Sweden
    Chromosome Res 9:53-9. 2001
    ..The assignment of IL1RN permitted analysis of gene order conservation between HSA2 and ECA15, which identified that an event of inversion had occurred during the evolution of these two homologous chromosomes...
  47. pmc A gene-based genetic linkage map of the collared flycatcher (Ficedula albicollis) reveals extensive synteny and gene-order conservation during 100 million years of avian evolution
    Niclas Backstrom
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, SE 752 36 Uppsala, Sweden
    Genetics 179:1479-95. 2008
    ..The degree of genome stability is likely to have important consequences for general evolutionary patterns and may explain, for example, the comparatively slow rate by which genetic incompatibility among lineages of birds evolves...
  48. doi request reprint To what extent do microsatellite markers reflect genome-wide genetic diversity in natural populations?
    Ulo Väli
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvägen, Uppsala, Sweden
    Mol Ecol 17:3808-17. 2008
    ..This suggests that researchers should consider using resequencing-based approaches for assessing genetic diversity when accurate inference is critical, as in many conservation and management contexts...
  49. doi request reprint No evidence for Z-chromosome rearrangements between the pied flycatcher and the collared flycatcher as judged by gene-based comparative genetic maps
    Niclas Backstrom
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, Uppsala, Sweden
    Mol Ecol 19:3394-405. 2010
    ..This study does therefore not provide support the idea that sex chromosome rearrangements have caused the relatively strong post-zygotic reproductive isolation between these two Ficedula species...
  50. ncbi request reprint Evolution: natural selection in the evolution of humans and chimps
    Hans Ellegren
    Department of Evolutionary Biology, Uppsala University, Sweden
    Curr Biol 15:R919-22. 2005
    ..Natural selection has eliminated about 75% of amino acid changes in coding sequence since the split of the human and chimpanzee genomes...
  51. ncbi request reprint Rapid evolution of female-biased, but not male-biased, genes expressed in the avian brain
    Judith E Mank
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 24:2698-706. 2007
    ....
  52. ncbi request reprint Adaptive molecular evolution of HINTW, a female-specific gene in birds
    Helene Ceplitis
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 21:249-54. 2004
    ....
  53. ncbi request reprint Evidence for turnover of functional noncoding DNA in mammalian genome evolution
    Nick G C Smith
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, 752 36 Uppsala, Sweden
    Genomics 84:806-13. 2004
    ..This result suggests that there is a high rate of turnover of functional noncoding elements in the mammalian genome, so measures of functional constraint based on human-mouse comparisons may seriously underestimate the true value...
  54. ncbi request reprint Strong regional biases in nucleotide substitution in the chicken genome
    Matthew T Webster
    Department of Evolution, Genomics and Systematics, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 23:1203-16. 2006
    ..The results suggest that an interaction between increased mutability at CpG motifs and fixation biases due to BGC could explain increased levels of divergence in GC-rich regions...
  55. ncbi request reprint Y chromosome haplotyping in Scandinavian wolves (Canis lupus) based on microsatellite markers
    A K Sundqvist
    Department of Evolutionary Biology, Uppsala University, , SE-752 36 Uppsala, Sweden
    Mol Ecol 10:1959-66. 2001
    ..The two Scandinavian Y chromosome haplotypes were not found elsewhere in northern Europe, which indicates low male gene flow between Scandinavia and the neighbouring countries...
  56. ncbi request reprint Evolutionary genetics. Clonal inheritance of avian mitochondrial DNA
    S Berlin
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, , SE-752 36, Uppsala, Sweden
    Nature 413:37-8. 2001
    ..Our results indicate that inheritance of mtDNA is free of detectable recombination effects over an evolutionary timescale...
  57. pmc Genetic mapping in a natural population of collared flycatchers (Ficedula albicollis): conserved synteny but gene order rearrangements on the avian Z chromosome
    Niclas Backstrom
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, SE 752 36 Uppsala, Sweden
    Genetics 174:377-86. 2006
    ..Interestingly, the rate of recombination on the Z chromosome of collared flycatchers was only approximately 50% that of chicken, challenging the widely held view that birds generally have high recombination rates...
  58. pmc Levels of linkage disequilibrium in a wild bird population
    Niclas Backstrom
    Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, 752 36 Uppsala, Sweden
    Biol Lett 2:435-8. 2006
    ....
  59. pmc The genomic landscape of short insertion and deletion polymorphisms in the chicken (Gallus gallus) Genome: a high frequency of deletions in tandem duplicates
    Mikael Brandstrom
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, SE 752 36 Uppsala, Sweden
    Genetics 176:1691-701. 2007
    ..The correlation between indel and SNP density indicates common effects of mutation and/or selection on the occurrence of indels and point mutations...
  60. pmc Comparison of the chicken and turkey genomes reveals a higher rate of nucleotide divergence on microchromosomes than macrochromosomes
    Erik Axelsson
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, SE 752 36 Uppsala, Sweden
    Genome Res 15:120-5. 2005
    ..094) are significantly lower than those of macrochromosomes (average, 0.185; P = 0.025), suggesting that the proteins of genes on microchromosomes are under greater evolutionary constraint...
  61. pmc Chicken W: a genetically uniform chromosome in a highly variable genome
    Sofia Berlin
    Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Proc Natl Acad Sci U S A 101:15967-9. 2004
    ..Reduced variability in female-specific W chromosomes is not easily explained by sexual selection...
  62. ncbi request reprint From wild wolf to domestic dog: gene expression changes in the brain
    Peter Saetre
    Department of Evolution, Genomics and Systematics, Uppsala University, Norbyvagen 18D, S 752 36 Uppsala, Sweden
    Brain Res Mol Brain Res 126:198-206. 2004
    ..Instead, they may provide a common mechanism for rapid adaptive changes during speciation, particularly in cases that present strong selective pressures on behavioral characters...
  63. ncbi request reprint Nonrandom distribution of genes with sex-biased expression in the chicken genome
    Vera B Kaiser
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Evolution 60:1945-51. 2006
    ..5). We also note that sexual selection for a male-biased trait is facilitated by Z-linkage, because sons in organisms with female heterogamety will always inherit a Z chromosome from their fathers...
  64. ncbi request reprint Gene conversion drives the evolution of HINTW, an ampliconic gene on the female-specific avian W chromosome
    Niclas Backstrom
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 22:1992-9. 2005
    ....
  65. pmc Cattle domestication in the Near East was followed by hybridization with aurochs bulls in Europe
    Anders Götherström
    Evolutionary Biology Centre, Uppsala University, Department of Evolutionary Biology, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Proc Biol Sci 272:2345-50. 2005
    ..Rather than originating from a few geographical areas only, as indicated by mtDNA, our data suggest that the origin of domestic cattle may be far more complex than previously thought...
  66. ncbi request reprint Inbreeding and relatedness in Scandinavian grey wolves Canis lupus
    H Ellegren
    Department of Evolutionary Biology, Uppsala University, Sweden
    Hereditas 130:239-44. 1999
    ..Since inbreeding depression has been documented in a captive grey wolf population of Scandinavian origin, the results point out an additional risk for the small Swedish wild population...
  67. ncbi request reprint Understanding the phylogeographic patterns of European hedgehogs, Erinaceus concolor and E. europaeus using the MHC
    K T Berggren
    Department of Evolutionary Biology, EBC, Uppsala University, Uppsala, Sweden
    Heredity (Edinb) 95:84-90. 2005
    ..Together with differences in variability, this suggests that the refugia history and/or expansion patterns of E. concolor and E. europaeus differ...
  68. ncbi request reprint Single-molecule analysis of the hypermutable tetranucleotide repeat locus D21S1245 through sperm genotyping: a heterogeneous pattern of mutation but no clear male age effect
    Jesper Brohede
    Department of Evolutionary Biology, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 21:58-64. 2004
    ..However, the absence of a clear male age effect is at odds with the idea of an increasing male mutation rate with age, which is thought to arise from the continuous replication of germline cells throughout adulthood...
  69. ncbi request reprint Genomics of natural bird populations: a gene-based set of reference markers evenly spread across the avian genome
    Niclas Backstrom
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Mol Ecol 17:964-80. 2008
    ....
  70. doi request reprint Quantification of adaptive evolution of genes expressed in avian brain and the population size effect on the efficacy of selection
    Erik Axelsson
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 26:1073-9. 2009
    ..Overall, these results highlight the link between the effective population size and positive as well as negative selection...
  71. pmc Prehistoric contacts over the Straits of Gibraltar indicated by genetic analysis of Iberian Bronze Age cattle
    Cecilia Anderung
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Proc Natl Acad Sci U S A 102:8431-5. 2005
    ..We also found a wild ox haplotype in the Iberian Bronze Age sample, reflecting local hybridization or backcrossing or that aurochs were hunted by these farming cultures...
  72. pmc Comparative genomics based on massive parallel transcriptome sequencing reveals patterns of substitution and selection across 10 bird species
    Axel Künstner
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Sweden
    Mol Ecol 19:266-76. 2010
    ..Overall, this study demonstrates the usefulness of next-generation sequencing for obtaining genomic resources for comparative genomic analysis of non-model organisms...
  73. ncbi request reprint Substitution rate heterogeneity and the male mutation bias
    Sofia Berlin
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18 D, Uppsala, SE 752 36, Sweden
    J Mol Evol 62:226-33. 2006
    ..68, p = 0.04). Our results suggest the importance of using extensive data sets from several genomic regions to avoid the effects of regional mutation rate variation and to ensure accurate estimates of alpha(m)...
  74. pmc Genome-wide analysis of microsatellite polymorphism in chicken circumventing the ascertainment bias
    Mikael Brandstrom
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Genome Res 18:881-7. 2008
    ....
  75. pmc Speciation in Ficedula flycatchers
    Anna Qvarnström
    Animal Ecology Department of Ecology and Evolution, Uppsala University, Norbyvagen 18D, 752 36 Uppsala, Sweden
    Philos Trans R Soc Lond B Biol Sci 365:1841-52. 2010
    ..We discuss how identification of the genes underlying the three major sources of reproductive isolation can be used to draw conclusions about links between the processes driving their evolution...
  76. ncbi request reprint Compositional evolution of noncoding DNA in the human and chimpanzee genomes
    Matthew T Webster
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 20:278-86. 2003
    ....
  77. pmc Microsatellite evolution inferred from human-chimpanzee genomic sequence alignments
    Matthew T Webster
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Proc Natl Acad Sci U S A 99:8748-53. 2002
    ..These observations have important consequences for understanding the molecular mechanisms of microsatellite mutation and for the development of improved measures of genetic distance...
  78. ncbi request reprint MHC class II genes in European wolves: a comparison with dogs
    Jennifer M Seddon
    Department of Evolutionary Biology, EBC, Uppsala University, Norbyvagen 18D, 752 36 Uppsala, Sweden
    Immunogenetics 54:490-500. 2002
    ..Furthermore, an extensive region of nucleotide sequence shared between DRB1 and DQB alleles and a shared motif suggests intergenic recombination may have contributed to MHC diversity in the Canidae...
  79. ncbi request reprint Life history and the male mutation bias
    Anna Bartosch-Härlid
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, 752 36 Uppsala, Sweden
    Evolution 57:2398-406. 2003
    ..In one case, a significant difference in alpha(m) between two clades was shown to be due to W-linked rates and not Z-linked rates, a result that suggests that mutation rates are not determined by replication alone...
  80. ncbi request reprint Gene expression, synteny, and local similarity in human noncoding mutation rates
    Matthew T Webster
    Department of Evolution, Genomics and Systematics, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 21:1820-30. 2004
    ....
  81. ncbi request reprint Male-driven biased gene conversion governs the evolution of base composition in human alu repeats
    Matthew T Webster
    Department of Evolution, Genomics and Systematics, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 22:1468-74. 2005
    ..This indicates that in addition to sexual dimorphism in recombination rates, the sexes also differ in the relative rates of crossover and gene conversion...
  82. ncbi request reprint Microsatellite genotyping of DNA isolated from claws left on tanned carnivore hides
    Eva Hedmark
    Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, 752 36 Uppsala, Sweden
    Int J Legal Med 119:370-3. 2005
    ..We thus conclude that the use of claws from tanned hides offers new possibilities to genetic studies of preserved mammalian specimens, for instance, in the monitoring of illegal trade...
  83. doi request reprint Pleiotropic constraint hampers the resolution of sexual antagonism in vertebrate gene expression
    Judith E Mank
    Evolutionary Biology Centre, Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Am Nat 171:35-43. 2008
    ..These results suggest that the resolution of sexually antagonistic gene expression is determined by the evolutionary constraints acting on any given antagonistic locus...
  84. ncbi request reprint Fast accumulation of nonsynonymous mutations on the female-specific W chromosome in birds
    Sofia Berlin
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18 D, 752 36, Uppsala, Sweden
    J Mol Evol 62:66-72. 2006
    ..We conclude that deleterious mutations are accumulating at a high rate on the avian W chromosome, probably as a result of the lack of recombination in this female-specific chromosome...
  85. ncbi request reprint Do avian mitochondria recombine?
    Sofia Berlin
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, 752 36 Uppsala, Sweden
    J Mol Evol 58:163-7. 2004
    ..We conclude that it is unlikely that mitochondrial recombination has large effects on mitochondrial genetic variability in birds...
  86. ncbi request reprint Genes of domestic mammals augmented by backcrossing with wild ancestors
    Carles Vila
    Department of Evolutionary Biology, Uppsala University, Norbyvagen 18D, 752 36 Uppsala, Sweden
    Trends Genet 21:214-8. 2005
    ..These results support the view that, contrary to common assumption, domestic and wild lineages might not have been clearly separated throughout their history...
  87. ncbi request reprint Combined use of maternal, paternal and bi-parental genetic markers for the identification of wolf-dog hybrids
    C Vila
    Department of Evolutionary Biology, Uppsala University, Sweden
    Heredity (Edinb) 90:17-24. 2003
    ..This finding confirms that inter-specific hybridization between wolves and dogs can occur in natural wolf populations. A possible correlation between hybridization and wolf population density and disturbance deserves further research...
  88. ncbi request reprint Physical anchorage and orientation of equine linkage groups by FISH mapping BAC clones containing microsatellite markers
    G Lindgren
    Department of Evolutionary Biology, Uppsala University, S 752 36 Uppsala, Sweden
    Anim Genet 32:37-9. 2001
    ..The microsatellite markers are located on nine different horse chromosomes, four of which (ECA6, ECA25, ECA27 and ECA28) had no previously in situ assigned markers...
  89. ncbi request reprint A comprehensive linkage map of the pig based on a wild pig-Large White intercross
    L Marklund
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Anim Genet 27:255-69. 1996
    ..4:1 but this parameter varied between chromosomes as well as between regions within chromosomes. An intriguing finding was that blood group loci were overrepresented at the distal ends of linkage groups...
  90. ncbi request reprint Low levels of nucleotide diversity in mammalian Y chromosomes
    Linda Hellborg
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 21:158-63. 2004
    ....
  91. pmc A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms
    Gane Ka Shu Wong
    Beijing Institute of Genomics of Chinese Academy of Sciences, Beijing Genomics Institute, Beijing Proteomics Institute, Beijing 101300, China
    Nature 432:717-22. 2004
    ..In fact, most of the SNPs originated before domestication, and there is little evidence of selective sweeps for adaptive alleles on length scales greater than 100 kilobases...
  92. ncbi request reprint Male-biased mutation rate and divergence in autosomal, z-linked and w-linked introns of chicken and Turkey
    Erik Axelsson
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Sweden
    Mol Biol Evol 21:1538-47. 2004
    ..47 and approximate 95% confidence intervals of 2.27 to 2.68. Our data are broadly consistent with the idea that mutation-rate differences between chromosomal classes can be explained by the male mutation bias alone...
  93. pmc Heterogeneity in the rate and pattern of germline mutation at individual microsatellite loci
    Jesper Brohede
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Nucleic Acids Res 30:1997-2003. 2002
    ..Thus, microsatellite mutation and evolution may be viewed as a dynamic and variable process...
  94. ncbi request reprint Human mutation--blame (mostly) men
    Hans Ellegren
    Nat Genet 31:9-10. 2002
  95. pmc Is the rate of insertion and deletion mutation male biased?: Molecular evolutionary analysis of avian and primate sex chromosome sequences
    Hannah Sundström
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, SE 752 36 Uppsala, Sweden
    Genetics 164:259-68. 2003
    ..A significant excess of deletion compared to insertion events is observed on the avian W chromosome, consistent with gradual DNA loss on a nonrecombining chromosome...
  96. ncbi request reprint Genomics: the dog has its day
    Hans Ellegren
    Nature 438:745-6. 2005
  97. pmc Deterministic mutation rate variation in the human genome
    Nick G C Smith
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, 752 36 Uppsala, Sweden
    Genome Res 12:1350-6. 2002
    ..We also show that noncoding substitution rates are significantly affected by G+C base composition, partly because the base composition is not at equilibrium...
  98. pmc Rescue of a severely bottlenecked wolf (Canis lupus) population by a single immigrant
    Carles Vila
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Proc Biol Sci 270:91-7. 2003
    ..Our results imply that even rare interpopulation migration can lead to the rescue and recovery of isolated and endangered natural populations...
  99. ncbi request reprint A low rate of simultaneous double-nucleotide mutations in primates
    Nick G C Smith
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 20:47-53. 2003
    ....
  100. ncbi request reprint Y chromosome conserved anchored tagged sequences (YCATS) for the analysis of mammalian male-specific DNA
    Linda Hellborg
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Mol Ecol 12:283-91. 2003
    ....