M Damberg

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. pmc Phenelzine treatment increases transcription factor AP-2 levels in rat brain
    Mattias Damberg
    Department of Neuroscience, Section of Pharmacology, Uppsala University, Uppsala, Sweden
    BMC Pharmacol 3:10. 2003
  2. pmc Brainstem levels of transcription factor AP-2 in rat are changed after treatment with phenelzine, but not with citalopram
    Cecilia Berggard
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, PO Box 593 BMC, SE 751 24, Uppsala, Sweden
    BMC Pharmacol 5:1. 2005
  3. ncbi Transcription factor AP-2beta genotype, striatal dopamine D2 receptor density and cerebrospinal fluid monoamine metabolite concentrations in humans
    M Damberg
    Department of Neuroscience, Section of Pharmacology, Uppsala University, Uppsala, Sweden
    J Neural Transm 111:537-45. 2004
  4. ncbi Transcription factor AP-2 and monoaminergic functions in the central nervous system
    M Damberg
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Uppsala, Sweden
    J Neural Transm 112:1281-96. 2005
  5. ncbi Transcription factor AP-2beta genotype associated with anxiety-related personality traits in women. A replication study
    Mattias Damberg
    Department of Neuroscience, Section of Pharmacology, Uppsala University, Uppsala, Sweden
    Neuropsychobiology 48:169-75. 2003
  6. ncbi Investigation of transcription factor AP-2 beta genotype in women with premenstrual dysphoric disorder
    Mattias Damberg
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Uppsala, Sweden
    Neurosci Lett 377:49-52. 2005
  7. ncbi Chronic citalopram treatment induces time-dependent changes in the expression and DNA-binding activity of transcription factor AP-2 in rat brain
    C Berggard
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, PO Box 593 BMC, SE 751 24, Uppsala, Sweden
    Eur Neuropsychopharmacol 13:11-7. 2003
  8. ncbi Genetic mechanisms of behavior--don't forget about the transcription factors
    M Damberg
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, SE-751 24 Uppsala, Sweden
    Mol Psychiatry 6:503-10. 2001
  9. ncbi Platelet MAO and personality--function and dysfunction
    L Oreland
    Department of Neuroscience, Uppsala University, Sweden
    Curr Med Chem 11:2007-16. 2004
  10. ncbi Smoking only explains part of the associations between platelet monoamine oxidase activity and personality
    L Oreland
    Department of Neuroscience, Section of Pharmacology, BMC, University of Uppsala, Sweden
    J Neural Transm 109:963-75. 2002

Detail Information

Publications22

  1. pmc Phenelzine treatment increases transcription factor AP-2 levels in rat brain
    Mattias Damberg
    Department of Neuroscience, Section of Pharmacology, Uppsala University, Uppsala, Sweden
    BMC Pharmacol 3:10. 2003
    ..We have also reported an association between a specific genotype of AP-2beta to personality traits, binge-eating disorder and platelet monoamine oxidase (MAO) activity...
  2. pmc Brainstem levels of transcription factor AP-2 in rat are changed after treatment with phenelzine, but not with citalopram
    Cecilia Berggard
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, PO Box 593 BMC, SE 751 24, Uppsala, Sweden
    BMC Pharmacol 5:1. 2005
    ..In addition, previous studies have shown that the levels of AP-2alpha and AP-2beta in rat whole brain were decreased after 10 days of treatment with citalopram (SSRI) and imipramine (TCA), and were increased with phenelzine (MAO-I)...
  3. ncbi Transcription factor AP-2beta genotype, striatal dopamine D2 receptor density and cerebrospinal fluid monoamine metabolite concentrations in humans
    M Damberg
    Department of Neuroscience, Section of Pharmacology, Uppsala University, Uppsala, Sweden
    J Neural Transm 111:537-45. 2004
    ..However, AP-2beta genotype was associated with CSF-levels of HVA (in women) and MHPG. These data may suggest a functional involvement of AP-2beta in the dopaminergic system, but should be interpreted with caution until replicated...
  4. ncbi Transcription factor AP-2 and monoaminergic functions in the central nervous system
    M Damberg
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Uppsala, Sweden
    J Neural Transm 112:1281-96. 2005
    ....
  5. ncbi Transcription factor AP-2beta genotype associated with anxiety-related personality traits in women. A replication study
    Mattias Damberg
    Department of Neuroscience, Section of Pharmacology, Uppsala University, Uppsala, Sweden
    Neuropsychobiology 48:169-75. 2003
    ..Hence, these data further suggest the human AP-2beta gene as a novel candidate gene in personality...
  6. ncbi Investigation of transcription factor AP-2 beta genotype in women with premenstrual dysphoric disorder
    Mattias Damberg
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Uppsala, Sweden
    Neurosci Lett 377:49-52. 2005
    ..To our knowledge, this is the first study investigating transcription factor AP-2beta genotype in women with PMDD. Hence, these results should be considered preliminary until replicated...
  7. ncbi Chronic citalopram treatment induces time-dependent changes in the expression and DNA-binding activity of transcription factor AP-2 in rat brain
    C Berggard
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, PO Box 593 BMC, SE 751 24, Uppsala, Sweden
    Eur Neuropsychopharmacol 13:11-7. 2003
    ..Elucidation of the molecular mechanisms underlying mental disorders is important for future drug development, where transcription factors might be important drug targets...
  8. ncbi Genetic mechanisms of behavior--don't forget about the transcription factors
    M Damberg
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, SE-751 24 Uppsala, Sweden
    Mol Psychiatry 6:503-10. 2001
    ....
  9. ncbi Platelet MAO and personality--function and dysfunction
    L Oreland
    Department of Neuroscience, Uppsala University, Sweden
    Curr Med Chem 11:2007-16. 2004
    ..A hypothesis is put forward, that such common transcription factors may not directly regulate platelet MAO expression, but rather mitochondrial density, or outer mitochondrial membrane surface...
  10. ncbi Smoking only explains part of the associations between platelet monoamine oxidase activity and personality
    L Oreland
    Department of Neuroscience, Section of Pharmacology, BMC, University of Uppsala, Sweden
    J Neural Transm 109:963-75. 2002
    ..Strong evidence that the regulation of platelet MAO activity takes place on a transcriptional level with an involvement of transcription factors, likely to also regulate central monoaminergic activity, are presented...
  11. ncbi Genes encoding for AP-2beta and the Serotonin Transporter are associated with the Personality Character Spiritual Acceptance
    Kent W Nilsson
    Centre for Clinical Research, Uppsala University, Central Hospital Västerås 1, SE 721 89 Västerås, Sweden
    Neurosci Lett 411:233-7. 2007
    ..Boys and girls with the combination of presence of the short 5-HTTLPR, and homozygosity for the long AP-2beta genotype scored significantly lower on Self-Transcendence and Spiritual Acceptance...
  12. ncbi Levels of transcription factors AP-2alpha and AP-2beta in the brainstem are correlated to monoamine turnover in the rat forebrain
    M Damberg
    Department of Neuroscience, Section of Pharmacology, Uppsala University, S-751 24 Uppsala, Sweden
    Neurosci Lett 313:102-4. 2001
    ..The data support our notion that the transcription factor AP-2 family is involved in the regulation of the monoaminergic systems and, therefore, might be involved in the pathophysiology of neuropsychiatric disorders...
  13. ncbi Monoamine oxidases: activities, genotypes and the shaping of behaviour
    L Oreland
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    J Neural Transm 114:817-22. 2007
    ..In girls, instead, homozygosity for the high activity MAO-A allele interacted with environment to predict criminality. Possible mechanisms underlying the role of monoamine oxidases for behaviour are discussed...
  14. ncbi Low platelet monoamine oxidase activity in Swedish imprisoned criminal offenders
    Håkan Garpenstrand
    Department of Neuroscience, Uppsala University, P O Box 593, BMC, 751 24 Uppsala, Sweden
    Eur Neuropsychopharmacol 12:135-40. 2002
    ..The results also suggest that low trbc MAO activity in criminal offenders is not an artefact of cigarette smoking...
  15. ncbi A regulatory monoamine oxidase a promoter polymorphism and personality traits
    Håkan Garpenstrand
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Neuropsychobiology 46:190-3. 2002
    ..We conclude that the structure of this MAOA promoter region does not have a large impact on the expression of personality characteristics in the present Swedish population...
  16. ncbi The serotonin 2A -1438 G/A receptor polymorphism in a group of Swedish male criminals
    Cecilia Berggard
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Uppsala, Sweden
    Neurosci Lett 347:196-8. 2003
    ..Neither were there any associations between the studied polymorphism and the type of crime committed...
  17. pmc Does the transcription factor AP-2beta have an impact on the genetic and early environmental influence on ethanol consumption?
    S Oreland
    Division of Pharmacology, Department of Pharmaceutical Biosciences, Uppsala University, P O Box 591, 751 24 Uppsala, Sweden
    J Neural Transm 117:1077-81. 2010
    ..Taken together, we found differences in brainstem TFAP-2beta protein between the AA and ANA rats...
  18. ncbi Role of monoamine oxidase A genotype and psychosocial factors in male adolescent criminal activity
    Kent W Nilsson
    Centre for Clinical Research, Uppsala University, Central Hospital Västerås, S 721 89 Västerås, Sweden
    Biol Psychiatry 59:121-7. 2006
    ..The aim of this study was to replicate recent findings that interactions between a polymorphism in the monoamine oxidase A (MAO-A) gene promoter region and psychosocial factors might predict male adolescent criminal activity...
  19. doi Transcription factor AP-2 beta genotype and psychosocial adversity in relation to adolescent depressive symptomatology
    Kent W Nilsson
    Centre for Clinical Research, Central Hospital, Uppsala University, 721 89, Vasteras, Sweden
    J Neural Transm 116:363-70. 2009
    ..Amongst carriers of one or two copies of the long allele, there was no difference in depressive symptoms despite differences in psychosocial environments...
  20. ncbi Chronic pharmacological treatment with certain antidepressants alters the expression and DNA-binding activity of transcription factor AP-2
    M Damberg
    Department of Neuroscience, Section of Pharmacology, Uppsala University, Sweden
    Life Sci 68:669-78. 2000
    ..An increased understanding of the function of transcription factors and their involvement in human disease, such as depression, could make it possible in the future to selectively modulate relevant target genes directly...
  21. ncbi Effect of long-term blockade of CRF(1) receptors on exploratory behaviour, monoamines and transcription factor AP-2
    Tanel Mällo
    Department of Psychology, Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, 50410 Tartu, Estonia
    Pharmacol Biochem Behav 77:855-65. 2004
    ..This suggests that CRF(1) receptor blockade counteracts certain mechanisms of habituation, possibly by reducing the LC activity...
  22. ncbi No association between a transcription factor Activating Protein 2beta (AP-2beta) gene variant and schizophrenia
    Erik G Jonsson
    Department of Clinical Neuroscience, HUBIN project, Psychiatry Section, Karolinska Institute and Hospital, SE 171 76 Stockholm, Sweden
    Neurosci Lett 330:290-2. 2002
    ..We conclude that the investigated AP-2beta variant is not of major importance to schizophrenia in the investigated Swedish population...