L Claesson-Welsh

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. ncbi request reprint [Islet of Langerhans transplantation in type I diabetes. Regulation of neovascularization in the transplant is a key question]
    Lena Claesson-Welsh
    Institutionen för genetik och patologi, Uppsala universitet, Rudbecklaboratoriet, Uppsala
    Lakartidningen 100:1210-1. 2003
  2. ncbi request reprint Signal transduction by vascular endothelial growth factor receptors
    L Claesson-Welsh
    Department of Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, 751 85 Uppsala, Sweden
    Biochem Soc Trans 31:20-4. 2003
  3. ncbi request reprint Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-gamma and migration of endothelial cells expressing Flt 1
    E Landgren
    Dept of Medical and Physiol Chemistry Biomedical Center, Uppsala, Sweden
    Oncogene 16:359-67. 1998
  4. ncbi request reprint Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors
    A Eriksson
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    J Biol Chem 270:7773-81. 1995
  5. ncbi request reprint A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex
    E Rupp
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Eur J Biochem 225:29-41. 1994
  6. ncbi request reprint Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules
    N Ito
    Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, Box 575, S 751 23 Uppsala, Sweden
    J Biol Chem 273:23410-8. 1998
  7. ncbi request reprint Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers
    K Huang
    Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, S 751 85, Uppsala, Sweden
    Int J Biochem Cell Biol 33:315-24. 2001
  8. ncbi request reprint Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization
    R Hooshmand-Rad
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, S 751 24, Sweden
    Exp Cell Res 257:245-54. 2000
  9. ncbi request reprint Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells
    M J Cross
    Department of Genetics, Rudbeck Laboratory, S 75185 Uppsala, Sweden
    J Cell Sci 113:643-51. 2000
  10. ncbi request reprint FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition
    M J Cross
    Dept of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjöldsväg 20, 751 85, Uppsala, Sweden
    Trends Pharmacol Sci 22:201-7. 2001

Collaborators

Detail Information

Publications62

  1. ncbi request reprint [Islet of Langerhans transplantation in type I diabetes. Regulation of neovascularization in the transplant is a key question]
    Lena Claesson-Welsh
    Institutionen för genetik och patologi, Uppsala universitet, Rudbecklaboratoriet, Uppsala
    Lakartidningen 100:1210-1. 2003
  2. ncbi request reprint Signal transduction by vascular endothelial growth factor receptors
    L Claesson-Welsh
    Department of Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, 751 85 Uppsala, Sweden
    Biochem Soc Trans 31:20-4. 2003
    ..This review focuses on the signal transduction properties of VEGF receptor-1 and VEGF receptor-2...
  3. ncbi request reprint Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-gamma and migration of endothelial cells expressing Flt 1
    E Landgren
    Dept of Medical and Physiol Chemistry Biomedical Center, Uppsala, Sweden
    Oncogene 16:359-67. 1998
    ....
  4. ncbi request reprint Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors
    A Eriksson
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    J Biol Chem 270:7773-81. 1995
    ..We conclude that phosphorylated Tyr-988 and Tyr-1018 in the PDGF alpha-receptor carboxyl-terminal tail bind PLC-gamma, but this association leads to only a relatively low level of tyrosine phosphorylation and activation of PLC-gamma...
  5. ncbi request reprint A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex
    E Rupp
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Eur J Biochem 225:29-41. 1994
    ....
  6. ncbi request reprint Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules
    N Ito
    Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, Box 575, S 751 23 Uppsala, Sweden
    J Biol Chem 273:23410-8. 1998
    ..These results indicate that a spectrum of already known as well as novel phosphotyrosine-binding molecules are involved in signal transduction by Flt-1...
  7. ncbi request reprint Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers
    K Huang
    Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, S 751 85, Uppsala, Sweden
    Int J Biochem Cell Biol 33:315-24. 2001
    ..The pattern of Ca2+ fluxes was unique for each type of VEGF receptor dimer. Our data show that signal transduction induced by VEGF-A is transduced in distinct manners by homo- and heterodimers of VEGF receptors...
  8. ncbi request reprint Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization
    R Hooshmand-Rad
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, S 751 24, Sweden
    Exp Cell Res 257:245-54. 2000
    ..We conclude that Shb plays a role in PDGF-dependent regulation of certain cytoskeletal changes by modulating the ability of PDGF to activate Rac...
  9. ncbi request reprint Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells
    M J Cross
    Department of Genetics, Rudbeck Laboratory, S 75185 Uppsala, Sweden
    J Cell Sci 113:643-51. 2000
    ..Furthermore, whilst tyrosine 766 was not required for a proliferative response, it was required for fibroblast growth factor receptor-1 mediated cytoskeletal reorganisation...
  10. ncbi request reprint FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition
    M J Cross
    Dept of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjöldsväg 20, 751 85, Uppsala, Sweden
    Trends Pharmacol Sci 22:201-7. 2001
    ..Furthermore, the manner in which this knowledge is being exploited to regulate angiogenesis will be discussed...
  11. pmc Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation
    A K Arvidsson
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Mol Cell Biol 14:6715-26. 1994
    ....
  12. ncbi request reprint Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins
    T Karlsson
    Department of Medical Cell Biology, Uppsala University, Sweden
    Oncogene 10:1475-83. 1995
    ..PDGF treatment did not affect the association between Eps8 and Shb. The data suggest that Shb is an adaptor protein linking SH3 domain proteins to tyrosine kinases or other tyrosine phosphorylated proteins...
  13. ncbi request reprint Direct interaction between Shc and the platelet-derived growth factor beta-receptor
    K Yokote
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    J Biol Chem 269:15337-43. 1994
    ..This is in contrast to previously characterized interactions between the PDGF beta-receptor and SH2 domain-containing proteins, which generally involve one high affinity binding site in the receptor...
  14. ncbi request reprint Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis
    J Dixelius
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden
    Blood 95:3403-11. 2000
    ..In conclusion, our data show that endostatin induces tyrosine kinase activity and enhanced apoptosis in FGF-treated endothelial cells...
  15. ncbi request reprint Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins
    J Saras
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    J Biol Chem 269:24082-9. 1994
    ..In addition to these structures PTPL1 has a region that fulfills the criteria for a leucine zipper motif. PTPL1 is the hitherto largest PTP identified and the only one known which contains a leucine zipper motif...
  16. ncbi request reprint Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains
    H Ichijo
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    J Biol Chem 268:14505-13. 1993
    ..On the other hand, ficolin-beta was mainly expressed in skeletal muscle. The in vivo functions of ficolin will be discussed...
  17. ncbi request reprint Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains
    S Valgeirsdottir
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Oncogene 16:505-15. 1998
    ..Members of the Janus kinase family were also shown to interact with the PDGF beta-receptor, and to a lesser extent with the alpha-receptor, but their importance for PDGF-induced Stat activation remains to be determined...
  18. pmc cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor
    L Claesson-Welsh
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Proc Natl Acad Sci U S A 86:4917-21. 1989
    ..The expressed protein was shown to display high-affinity binding of all three 125I-labeled dimeric forms of PDGF A and B chains in a manner that is characteristic for the PDGF A-type receptor...
  19. ncbi request reprint cDNA cloning and expression of a human FGF receptor which binds acidic and basic FGF
    S Wennström
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Growth Factors 4:197-208. 1991
    ..From Scatchard analyses, the Kd:s for binding of aFGF and bFGF to hFGFR-1 were estimated to 25 pM and 41 pM, respectively. Thus, phFGFR encodes a human FGF receptor with high affinity for both aFGF and bFGF...
  20. ncbi request reprint Structural properties of 3.0 kb and 3.2 kb transcripts encoding platelet-derived endothelial cell growth factor/thymidine phosphorylase in A431 cells
    K Usuki
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Biochim Biophys Acta 1222:411-4. 1994
    ..8 kb transcript. Comparison with the published PD-ECGF/TP genomic sequence shows that the long 5' leader sequence contain 7 of 8 copies of Sp-1 binding sites present in the transcription promoter region of the 1.8 kb transcript...
  21. ncbi request reprint Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis
    Svante Bohman
    Department of Genetics and Pathology, Uppsala University, Dag Hammarskjölds väg 20, S 751 85 Uppsala, Sweden
    J Biol Chem 280:42397-404. 2005
    ..Antisense- and small interfering RNA-mediated suppression of CLIC4 expression led to arrest in tubular morphogenesis. Our data implicate CLIC4 in formation of a vessel lumen...
  22. ncbi request reprint Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation
    Charlotte Rolny
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv 20, 751 85 Uppsala, Sweden
    Blood 108:1877-86. 2006
    ..Moreover, enhanced vascular remodeling was evident in the Rosa26-PDGF-BB yolk sacs. We conclude that PDGFR-beta is expressed on early hemangioprecursor cells, regulating vascular/hematopoietic development...
  23. ncbi request reprint Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis
    Lars Jakobsson
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Dag Hammarskjoldsv 20, SE 75185 Uppsala, Sweden
    Dev Cell 10:625-34. 2006
    ..We propose that transactivation of tyrosine kinase receptors by HSPGs constitutes a mechanism for crosstalk between adjacent cells...
  24. ncbi request reprint Lentiviral rescue of vascular endothelial growth factor receptor-2 expression in flk1-/- embryonic stem cells shows early priming of endothelial precursors
    Xiujuan Li
    Rudbeck Laboratory, Department Genetics and Pathology, Uppsala University, Dag Hammarskjoldsv 20, 751 85 Uppsala, Sweden
    Stem Cells 25:2987-95. 2007
    ..We conclude that maturation of endothelial precursors, as well as organization into vascular structures, requires expression of VEGFR-2. Disclosure of potential conflicts of interest is found at the end of this article...
  25. ncbi request reprint Early lymph vessel development from embryonic stem cells
    Johan Kreuger
    Department of Genetics and Pathology, Uppsala University, Sweden
    Arterioscler Thromb Vasc Biol 26:1073-8. 2006
    ..The purpose of this study was to establish a model system for lymph vessel development based on directed differentiation of murine embryonic stem cells...
  26. ncbi request reprint Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein
    Johan Dixelius
    Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Cancer Res 66:2089-97. 2006
    ..In conclusion, HRGP330, which we define as the minimal antiangiogenic domain of HRGP, exerts its effects through signal transduction targeting focal adhesions, thereby interrupting VEGF-induced endothelial cell motility...
  27. ncbi request reprint The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner
    Maarten Vanwildemeersch
    Department of Medical Biochemistry and Microbiology, Uppsala University, SE 75123 Uppsala, Sweden
    J Biol Chem 281:10298-304. 2006
    ....
  28. pmc VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis
    Taro Matsumoto
    Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    EMBO J 24:2342-53. 2005
    ..Tumor vascularization and growth was reduced in TSAd-deficient mice, indicating a critical role of Y951-TSAd signaling in pathological angiogenesis...
  29. ncbi request reprint Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
    Masabumi Shibuya
    University of Tokyo, Institute of Medical Science, 4 6 1 Shirokane dai, Tokyo 108 8639, Japan
    Exp Cell Res 312:549-60. 2006
    ..Mapping the signaling system of these important receptors may provide the knowledge necessary to suppress specific signaling pathways in major human diseases...
  30. ncbi request reprint Signal transduction in endothelial cells by the angiogenesis inhibitor histidine-rich glycoprotein targets focal adhesions
    Chunsik Lee
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
    Exp Cell Res 312:2547-56. 2006
    ..In conclusion, our data show that HRGP targets focal adhesions in endothelial cells, thereby disrupting the cytoskeletal organization and the ability of endothelial cells to assemble into vessel structures...
  31. pmc Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization
    Harukiyo Kawamura
    Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala, University, Uppsala, Sweden
    Blood 112:3638-49. 2008
    ..Our data strongly indicate that the ability of VEGF ligands to bind NRP1 influences p38MAPK activation, and formation of functional, pericyte-associated vessels...
  32. doi request reprint Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity
    Harukiyo Kawamura
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Cancer Res 68:4683-92. 2008
    ..Our data indicate that loss of VEGFR-2/NRP1 complex formation and Y1052 phosphorylation contribute to the lack of angiogenic properties of VEGF-A165b...
  33. doi request reprint Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR
    Stéphanie Cébe-Suarez
    Paul Scherrer Institut, Laboratory of Biomolecular Research, Molecular Cell Biology, 5232 Villigen PSI Switzerland
    FASEB J 22:3078-86. 2008
    ..Functional studies showed that stable coreceptor assembly by VEGF correlated with its ability to promote vessel formation in an embryoid body angiogenesis assay...
  34. ncbi request reprint Laminin deposition is dispensable for vasculogenesis but regulates blood vessel diameter independent of flow
    Lars Jakobsson
    Department of Genetics and Pathology, Uppsala University, Dag Hammarskjoldsv 20, SE 75185, Uppsala, Sweden
    FASEB J 22:1530-9. 2008
    ..We conclude that laminins are dispensable for vascular development but that they regulate lumen formation in the absence of flow and vascular tone...
  35. ncbi request reprint alphaB-crystallin promotes tumor angiogenesis by increasing vascular survival during tube morphogenesis
    Anna Dimberg
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Blood 111:2015-23. 2008
    ..Hereby we identify the small heat shock protein family as a novel class of angiogenic modulators...
  36. ncbi request reprint FGFR-1 regulates angiogenesis through cytokines interleukin-4 and pleiotrophin
    Peetra U Magnusson
    Department of Genetics and Pathology, Uppsala University, The Rudbeck Laboratory, Uppsala, Sweden
    Blood 110:4214-22. 2007
    ..We conclude that FGFR-1 negatively regulates endothelial cell function by altering the balance of modulatory cytokines...
  37. pmc Angiomotin regulates endothelial cell migration during embryonic angiogenesis
    Karin Aase
    Department of Oncology Pathology, Cancer Center Karolinska, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Genes Dev 21:2055-68. 2007
    ..Our data demonstrate a critical role for Amot during vascular patterning and endothelial polarization...
  38. ncbi request reprint Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro
    Peetra U Magnusson
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Arterioscler Thromb Vasc Biol 27:2142-9. 2007
    ..This study describes the consequences of a constitutively activating mutation of the PDGFR-beta (Pdgfrb(D849V)) introduced into embryonic stem cells with respect to vasculogenesis/angiogenesis in vitro and in vivo...
  39. ncbi request reprint Fibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development
    Peetra Ulrica Magnusson
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Arterioscler Thromb Vasc Biol 25:944-9. 2005
    ..The purpose of this study was to clarify the role of fibroblast growth factors (FGFs) and FGF receptors (FGFRs) in hematopoietic/endothelial development...
  40. ncbi request reprint The minimal active domain of endostatin is a heparin-binding motif that mediates inhibition of tumor vascularization
    Anna Karin Olsson
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden
    Cancer Res 64:9012-7. 2004
    ..Substitution of arginine residues 193/194 for alanine attenuates the antiangiogenic effects of the peptide. These data show an essential role for heparin binding in the antiangiogenic action of endostatin...
  41. ncbi request reprint Vascular endothelial growth factor receptor-3 in hypoxia-induced vascular development
    Ingrid Nilsson
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    FASEB J 18:1507-15. 2004
    ..In addition, sequestering of VEGF receptor-3 ligands reduced vascularization in a manner similar to neutralization of VEGF receptor-3. We conclude that hypoxia-driven vascular development requires the activity of VEGF receptor-3...
  42. ncbi request reprint [Anti-angiogenic drugs probable complement in cancer therapy]
    Rolf Christofferson
    Barnkirurgiska kliniken, Akademiska sjukhuset, Uppsala
    Lakartidningen 99:4138-9, 4142-8. 2002
    ..In many cases combination therapy with an anti-angiogenic substance together with radiation, chemotherapy or other types of conventional tumor treatment, appears promising...
  43. ncbi request reprint Endostatin regulates endothelial cell adhesion and cytoskeletal organization
    Johan Dixelius
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, 751 85 Uppsala, Sweden
    Cancer Res 62:1944-7. 2002
    ..These data provide a molecular basis both for the lack of effect of endostatin on the normal, quiescent vasculature, and its antagonistic effects on stimulated tumor vessels...
  44. pmc Role of heparan sulfate domain organization in endostatin inhibition of endothelial cell function
    Johan Kreuger
    Department of Medical Biochemistry and Microbiology, Uppsala University, PO Box 582, SE 75123 Uppsala, Sweden
    EMBO J 21:6303-11. 2002
    ..The results provide a rational explanation for the preferential interaction of ES with certain HS proteoglycan species...
  45. ncbi request reprint Angiostatin and endostatin inhibit endothelial cell migration in response to FGF and VEGF without interfering with specific intracellular signal transduction pathways
    Kerstin Eriksson
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, S 751 85 Uppsala, Sweden
    FEBS Lett 536:19-24. 2003
    ..We conclude that angiostatin and endostatin inhibit chemotaxis, without affecting intracellular signalling pathways known to regulate endothelial migration and proliferation/survival...
  46. ncbi request reprint Heparin amplifies platelet-derived growth factor (PDGF)- BB-induced PDGF alpha -receptor but not PDGF beta -receptor tyrosine phosphorylation in heparan sulfate-deficient cells. Effects on signal transduction and biological responses
    Charlotte Rolny
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Dag Hammarskjölds v 20, 751 85 Uppsala, Sweden
    J Biol Chem 277:19315-21. 2002
    ..In conclusion, heparin modulates PDGF-BB-induced PDGF alpha-receptor phosphorylation and downstream signaling, with consequences for cellular responsiveness to the growth factor...
  47. ncbi request reprint A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2
    Jian Hua Qi
    Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Nat Med 9:407-15. 2003
    ..This property seems to be independent of its MMP-inhibitory activity, indicating a new function for this molecule...
  48. ncbi request reprint Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin
    Lars Lundin
    Department of Genetics and Pathology, Uppsala University, The Rudbeck Laboratory, S 751 85, Uppsala, Sweden
    Exp Cell Res 287:190-8. 2003
    ..Our data imply that tyrosine 463 is phosphorylated and able to transduce signals in response to FGF-2 treatment alone; furthermore, we suggest that FGFR-1 dimerization/kinase activation is stabilized by heparin...
  49. pmc p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis
    Taro Matsumoto
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, S 751 85, Sweden
    J Cell Biol 156:149-60. 2002
    ..These results implicate p38 in organization of new vessels and suggest that p38 is an essential regulator of FGF-2-driven angiogenesis...
  50. ncbi request reprint Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites
    Johan Dixelius
    Department of Genetics and Pathology, Uppsala University, Dag Hammarskjölds väg 20, S 751 85 Uppsala, Sweden
    J Biol Chem 278:40973-9. 2003
    ....
  51. ncbi request reprint VEGF-receptor signal transduction
    Michael J Cross
    Department of Genetics and Pathology, Dag Hammarskjöldsväg 20, 751 85 Uppsala, Sweden
    Trends Biochem Sci 28:488-94. 2003
    ..More recent data indicate essential roles for the VEGFs in haematopoietic cell function and in lymphangiogenesis...
  52. ncbi request reprint Translocated in liposarcoma (TLS) is a substrate for fibroblast growth factor receptor-1
    Peter Klint
    Rudbeck Laboratory, Department of Genetics and Pathology, 751 85, Uppsala, Sweden
    Cell Signal 16:515-20. 2004
    ..We show that TLS is tyrosine phosphorylated in intact cells by a number of different growth factors, indicating a role in growth regulation...
  53. ncbi request reprint A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization
    Anna Karin Olsson
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden
    Cancer Res 64:599-605. 2004
    ..This study shows for the first time inhibitory effects of HRGP on tumor vascularization in vivo, thus providing proof of concept that HRGP is an angiogenesis inhibitor...
  54. ncbi request reprint Deregulation of Flk-1/vascular endothelial growth factor receptor-2 in fibroblast growth factor receptor-1-deficient vascular stem cell development
    Peetra Magnusson
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Dag Hammarskjoldsv 20, 751 85 Uppsala, Sweden
    J Cell Sci 117:1513-23. 2004
    ..We conclude that VEGF-A/VEGFR-2-dependent vessel formation occurs in the absence of FGF-2/FGFR-1, which, however, serve to modulate vascular development...
  55. ncbi request reprint The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration
    Kristina Holmqvist
    Department of Medical Cell Biology, Uppsala University, Uppsala 75123, Sweden
    J Biol Chem 279:22267-75. 2004
    ..This is achieved by Shb binding to tyrosine 1175 in the VEGFR-2, which regulates VEGF-induced formation of focal adhesions and cell migration, of which the latter occurs in a phosphatidylinositol 3-kinase-dependent manner...
  56. ncbi request reprint Laminin-1 promotes angiogenesis in synergy with fibroblast growth factor by distinct regulation of the gene and protein expression profile in endothelial cells
    Johan Dixelius
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjöldsvaüg 20, S 751 85 Uppsala, Sweden
    J Biol Chem 279:23766-72. 2004
    ..Taken together, this suggests that laminins may play a fundamental role in angiogenesis by directly affecting gene and protein expression profiles in endothelial cells...
  57. pmc The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells
    Michael J Cross
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Sweden
    Mol Biol Cell 13:2881-93. 2002
    ..We conclude, that Shb binds to tyrosine 766 in the FGFR-1 and regulates FGF-mediated mitogenicity via FRS2 phosphorylation and the subsequent activation of the Ras/MEK/MAPK pathway...
  58. pmc Functional tyrosine kinase inhibitor profiling: a generally applicable method points to a novel role of platelet-derived growth factor receptor-beta in tuberous sclerosis
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Pathol 161:781-6. 2002
    ..Thus, we describe a novel but simple method of determining the functional tyrosine kinase profile of a neoplastic cell and our results suggest that STI571 might be useful in the treatment of neoplasms commonly seen in patients with TS...
  59. ncbi request reprint VEGF receptor signalling - in control of vascular function
    Anna Karin Olsson
    Department of Genetics and Pathology, Rudbeck Laboratory, Dag Hammarskjöldv 20, 751 85 Uppsala, Sweden
    Nat Rev Mol Cell Biol 7:359-71. 2006
    ..Recent insights have shed light onto VEGFR signal transduction and the interplay between different VEGFRs and VEGF co-receptors in development, adult physiology and disease...
  60. pmc Building blood vessels--stem cell models in vascular biology
    Lars Jakobsson
    Department of Genetics and Pathology, Uppsala University, SE 751 85 Uppsala, Sweden
    J Cell Biol 177:751-5. 2007
    ..This review examines vasculogenesis and angiogenesis in murine embryoid bodies and discusses the promise of stem cell-based models for the study of human vascular development...
  61. ncbi request reprint Endostatin action and intracellular signaling: beta-catenin as a potential target?
    Johan Dixelius
    Department of Genetics and Pathology, Rudbeck Laboratory, Dag Hammarskjölds v 20, 751 85 Uppsala, Sweden
    Cancer Lett 196:1-12. 2003
    ..An interesting candidate for transducing endostatin's effect on apoptosis and cell migration is beta-catenin, an intracellular protein which participates both in cell adhesion and in transcriptional regulation...
  62. doi request reprint VEGF-B taken to our hearts: specific effect of VEGF-B in myocardial ischemia
    Lena Claesson-Welsh
    Arterioscler Thromb Vasc Biol 28:1575-6. 2008