Hans Basun

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. pmc Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease
    Hans Basun
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden
    Arch Neurol 65:499-505. 2008
  2. pmc Reduced prostaglandin F2 alpha release from blood mononuclear leukocytes after oral supplementation of omega3 fatty acids: the OmegAD study
    Inger Vedin
    Department of Medicine, Caring Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Lipid Res 51:1179-85. 2010
  3. pmc Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study
    Inger Vedin
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    PLoS ONE 7:e35425. 2012
  4. doi request reprint Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n - 3 fatty acid supplementation in patients with Alzheimer's disease: the OmegAD study
    Gerd Faxén-Irving
    Department of NVS, Section of Clinical Nutrition, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Alzheimers Dis 36:1-6. 2013
  5. doi request reprint Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers
    Erik Hjorth
    Division of Neurodegeneration, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 35:697-713. 2013
  6. ncbi request reprint Clinical findings in nondemented mutation carriers predisposed to Alzheimer's disease: a model of mild cognitive impairment
    Ove Almkvist
    Division of Clinical Geriatrics and Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Acta Neurol Scand Suppl 179:77-82. 2003
  7. ncbi request reprint Extended investigation of tau and mutation screening of other candidate genes on chromosome 17q21 in a Swedish FTDP-17 family
    Susanne Froelich Fabre
    Department of Neurotec, Section of Experimental Geriatrics, Karolinska Institutet, Huddinge, Sweden
    Am J Med Genet B Neuropsychiatr Genet 121:112-8. 2003
  8. ncbi request reprint Nutritional and cognitive relationships and long-term mortality in patients with various dementia disorders
    Gerd Faxén-Irving
    Karolinska Institutet, Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Age Ageing 34:136-41. 2005
  9. ncbi request reprint [Conformationally altered proteins cause neurodegenerative diseases]
    Martin Ingelsson
    Geriatriska kliniken, AstraZeneca, Uppsala, Sweden
    Lakartidningen 102:3542-3, 3545-6, 3549 passim. 2005
  10. doi request reprint Higher cathepsin B levels in plasma in Alzheimer's disease compared to healthy controls
    Johan Sundelöf
    Uppsala University, Department of Public Health Geriatrics, Uppsala, Sweden
    J Alzheimers Dis 22:1223-30. 2010

Collaborators

Detail Information

Publications25

  1. pmc Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease
    Hans Basun
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden
    Arch Neurol 65:499-505. 2008
    ..Most of these mutations may also cause cognitive impairment, but the Arctic APP mutation is the only known intra-beta-amyloid mutation to date causing the more typical clinical picture of Alzheimer disease...
  2. pmc Reduced prostaglandin F2 alpha release from blood mononuclear leukocytes after oral supplementation of omega3 fatty acids: the OmegAD study
    Inger Vedin
    Department of Medicine, Caring Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Lipid Res 51:1179-85. 2010
    ..The stimulus-specific PGF(2alpha) release from PBMC after 6 months of oral supplementation with the DHA-rich fish oil might be one event related to reduced inflammatory reactions associated with omega-3 fatty acid intake...
  3. pmc Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study
    Inger Vedin
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    PLoS ONE 7:e35425. 2012
    ..Hence, our aim was to determine the effects of 6 mo of dietary supplementation with an n-3 FA preparation rich in DHA on global gene expression in peripheral blood mononuclear cells...
  4. doi request reprint Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n - 3 fatty acid supplementation in patients with Alzheimer's disease: the OmegAD study
    Gerd Faxén-Irving
    Department of NVS, Section of Clinical Nutrition, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Alzheimers Dis 36:1-6. 2013
    ..172, p = 0.028). Thus, n - 3 FA treatment appeared to increase plasma-TTR in patients with AD. Since TTR may influence Aβ deposition in the brain, the results warrant further exploration...
  5. doi request reprint Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers
    Erik Hjorth
    Division of Neurodegeneration, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 35:697-713. 2013
    ..DHA and EPA can be beneficial in AD by enhancing removal of Aβ42, increasing neurotrophin production, decreasing pro-inflammatory cytokine production, and by inducing a shift in phenotype away from pro-inflammatory M1 activation...
  6. ncbi request reprint Clinical findings in nondemented mutation carriers predisposed to Alzheimer's disease: a model of mild cognitive impairment
    Ove Almkvist
    Division of Clinical Geriatrics and Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Acta Neurol Scand Suppl 179:77-82. 2003
    ..In conclusion, clinical examinations of relatively young individuals carrying an AD mutation did not reveal any marked abnormalities before the clinical onset of dementia...
  7. ncbi request reprint Extended investigation of tau and mutation screening of other candidate genes on chromosome 17q21 in a Swedish FTDP-17 family
    Susanne Froelich Fabre
    Department of Neurotec, Section of Experimental Geriatrics, Karolinska Institutet, Huddinge, Sweden
    Am J Med Genet B Neuropsychiatr Genet 121:112-8. 2003
    ..Further investigation of extended intron sequences or promoter regions of the tau gene and additional candidate genes on chromosome 17q21, therefore seems to be necessary in order to identify the additional causes of FTDP-17...
  8. ncbi request reprint Nutritional and cognitive relationships and long-term mortality in patients with various dementia disorders
    Gerd Faxén-Irving
    Karolinska Institutet, Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Age Ageing 34:136-41. 2005
    ..Subjects with dementia are at risk for protein-energy malnutrition...
  9. ncbi request reprint [Conformationally altered proteins cause neurodegenerative diseases]
    Martin Ingelsson
    Geriatriska kliniken, AstraZeneca, Uppsala, Sweden
    Lakartidningen 102:3542-3, 3545-6, 3549 passim. 2005
    ..As of today, only symptomatic pharmacotherapies are available, but new insights into the underlying molecular mechanisms are providing strategies to prevent or even cure these devastating disorders...
  10. doi request reprint Higher cathepsin B levels in plasma in Alzheimer's disease compared to healthy controls
    Johan Sundelöf
    Uppsala University, Department of Public Health Geriatrics, Uppsala, Sweden
    J Alzheimers Dis 22:1223-30. 2010
    ..Further investigation of cathepsin B as a predictor of AD is warranted...
  11. ncbi request reprint [Don't underestimate the value of transgenic animal models of Alzheimer disease]
    Lars N G Nilsson
    Uppsala universitet
    Lakartidningen 104:798-9; discussion 799-800. 2007
  12. doi request reprint Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation
    Lena Skoglund
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Neurogenetics 10:27-34. 2009
    ..In conclusion, the PGRN Gly35fs mutation causes frontotemporal dementia with variable clinical presentation in a large Swedish family, most likely through nonsense-mediated decay of mutant PGRN mRNA and resulting haploinsufficiency...
  13. doi request reprint Cystatin C levels are positively correlated with both Abeta42 and tau levels in cerebrospinal fluid in persons with Alzheimer's disease, mild cognitive impairment, and healthy controls
    Johan Sundelöf
    Uppsala University, Department of Public Health Geriatrics, Uppsala, Sweden
    J Alzheimers Dis 21:471-8. 2010
    ..Interestingly, cystatin C levels were positively correlated with both tau and Abeta42 levels in CSF independent of age, gender, and APOE genotype...
  14. doi request reprint Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study
    Gerd Faxén Irving
    Department of Neurobiology, Karolinska Institutet, Karolinska University, Hospital Huddinge, Stockholm, Sweden
    J Am Geriatr Soc 57:11-7. 2009
    ..To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer's disease (AD) in relation to inflammatory biomarkers and apolipoprotein E epsilon4 (APOEepsilon4)...
  15. ncbi request reprint Plasma levels of Abeta42 and Abeta40 in Alzheimer patients during treatment with the acetylcholinesterase inhibitor tacrine
    Hans Basun
    Department of Neurotec, Karolinska Institutet, Huddinge University Hospital, Sweden
    Dement Geriatr Cogn Disord 14:156-60. 2002
    ..This finding may indicate that compensatory mechanisms have started at 6 weeks and that no long-term effect on key pathological features in AD is to be expected by an inhibition of acetylcholinesterase...
  16. ncbi request reprint Relationship between mercury concentration in blood, cognitive performance, and blood pressure, in an elderly urban population
    Nina Johansson
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Biometals 15:189-95. 2002
    ..There was no relation found between B-Hg concentration and cognitive function, arterial BP, age, gender or BMI. In conclusion, no relations were found between B-Hg concentrations and the studied variables...
  17. doi request reprint Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort study
    Johan Sundelöf
    Uppsala University, Department of Public Health and Geriatrics, Uppsala Science Park, Dag Hammarskölds väg 14B, Uppsala, Sweden
    Arch Neurol 65:256-63. 2008
    ..Beta amyloid (Abeta) protein accumulates in the brains of individuals with Alzheimer disease (AD) and is detectable in cerebrospinal fluid and plasma...
  18. ncbi request reprint No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found
    Janel Johnson
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 10, Room 6C103, MSC1589, Bethesda, MD 20892, USA
    Neurosci Lett 363:99-101. 2004
    ..We did not find any such mutations...
  19. ncbi request reprint Longitudinal stability of CSF biomarkers in Alzheimer's disease
    Kaj Blennow
    Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden
    Neurosci Lett 419:18-22. 2007
    ....
  20. ncbi request reprint Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial
    Yvonne Freund-Levi
    Department of Neurobiology, Caring Sciences and Society, Section of Clinical Geriatrics, Karolinska University Hospital Huddinge, Stockholm
    Arch Neurol 63:1402-8. 2006
    ..Epidemiologic and animal studies have suggested that dietary fish or fish oil rich in omega-3 fatty acids, for example, docosahexaenoic acid and eicosapentaenoic acid, may prevent Alzheimer disease (AD)...
  21. ncbi request reprint Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms
    Yvonne Freund-Levi
    Department of NVS, Section of Clinical Geriatrics, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    Int J Geriatr Psychiatry 23:161-9. 2008
    ..An association with APOEomega4 carriers and neuropsychiatric symptoms in AD has also been suggested...
  22. ncbi request reprint Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study
    Inger Vedin
    Department of Medicine and the Division of Clinical Nutrition and Metabolism Research, Uppsala University Hospital, Uppsala, Sweden
    Am J Clin Nutr 87:1616-22. 2008
    ..Whereas most studies have explored the effects of predominantly EPA-based n-3 FAs preparations, few have addressed the effects of n-3 FAs preparations with DHA as the main FA...
  23. ncbi request reprint Determination of isoprostanes in urine samples from Alzheimer patients using porous graphitic carbon liquid chromatography-tandem mass spectrometry
    Kristina Claeson Bohnstedt
    Department of Analytical Chemistry, Stockholm University, SE 106 91 Stockholm, Sweden
    J Chromatogr B Analyt Technol Biomed Life Sci 796:11-9. 2003
    ..The results from this study support earlier findings that levels of peripheral isoprostanes are not increased in patients with Alzheimer's disease...
  24. ncbi request reprint White matter lesions and soluble interleukin-1 receptor type II in CSF from demented and non-demented subjects
    Lena Bronge
    Department of Radiology, Huddinge University Hospital, S 141 86 Huddinge, Sweden
    Neurochem Int 41:217-22. 2002
    ..In conclusion, sIL-1RII levels in CSF are not correlated to magnetic resonance imaging WMLs in patients with dementia disorders or in healthy subjects...
  25. ncbi request reprint Clinical and molecular aspects of frontotemporal dementia
    Susanne Froelich-Fabre
    Department of Public Health and Caring Science, Division of Geriatrics, Uppsala University, Uppsala, Sweden
    Neurodegener Dis 1:218-24. 2004
    ..However, tau mutations seem to be a rare cause of disease in the general FTD population. Thus, other genes and/or environmental factors are yet to be identified, which will give further clues to this complex and heterogeneous disorder...