Leif Andersson

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. ncbi request reprint IGF2 antisense transcript expression in porcine postnatal muscle is affected by a quantitative trait nucleotide in intron 3
    Martin H Braunschweig
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, SE 751 24 Uppsala, Sweden
    Genomics 84:1021-9. 2004
  2. doi request reprint Genome-wide association analysis in domestic animals: a powerful approach for genetic dissection of trait loci
    Leif Andersson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    Genetica 136:341-9. 2009
  3. pmc The Rose-comb mutation in chickens constitutes a structural rearrangement causing both altered comb morphology and defective sperm motility
    Freyja Imsland
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 8:e1002775. 2012
  4. pmc Sensory ataxic neuropathy in golden retriever dogs is caused by a deletion in the mitochondrial tRNATyr gene
    Izabella Baranowska
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    PLoS Genet 5:e1000499. 2009
  5. pmc Identification of the yellow skin gene reveals a hybrid origin of the domestic chicken
    Jonas Eriksson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 4:e1000010. 2008
  6. pmc Contrasting mode of evolution at a coat color locus in wild and domestic pigs
    Meiying Fang
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    PLoS Genet 5:e1000341. 2009
  7. pmc ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth
    Ellen Markljung
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Biol 7:e1000256. 2009
  8. pmc Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation
    Anders R Hellström
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 7:e1002285. 2011
  9. pmc Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens
    Dominic Wright
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 5:e1000512. 2009
  10. pmc A complex genomic rearrangement involving the endothelin 3 locus causes dermal hyperpigmentation in the chicken
    Ben Dorshorst
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 7:e1002412. 2011

Collaborators

Detail Information

Publications81

  1. ncbi request reprint IGF2 antisense transcript expression in porcine postnatal muscle is affected by a quantitative trait nucleotide in intron 3
    Martin H Braunschweig
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, SE 751 24 Uppsala, Sweden
    Genomics 84:1021-9. 2004
    ....
  2. doi request reprint Genome-wide association analysis in domestic animals: a powerful approach for genetic dissection of trait loci
    Leif Andersson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    Genetica 136:341-9. 2009
    ..This is an excellent illustration of how the characterization of alleles selected during animal domestication contributes to an improved understanding of genotype-phenotype relationships...
  3. pmc The Rose-comb mutation in chickens constitutes a structural rearrangement causing both altered comb morphology and defective sperm motility
    Freyja Imsland
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 8:e1002775. 2012
    ....
  4. pmc Sensory ataxic neuropathy in golden retriever dogs is caused by a deletion in the mitochondrial tRNATyr gene
    Izabella Baranowska
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    PLoS Genet 5:e1000499. 2009
    ..Altogether, these results provide conclusive evidence that the deletion in the mitochondrial tRNA(Tyr) gene is the causative mutation for SAN...
  5. pmc Identification of the yellow skin gene reveals a hybrid origin of the domestic chicken
    Jonas Eriksson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 4:e1000010. 2008
    ..This is the first conclusive evidence for a hybrid origin of the domestic chicken, and it has important implications for our views of the domestication process...
  6. pmc Contrasting mode of evolution at a coat color locus in wild and domestic pigs
    Meiying Fang
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    PLoS Genet 5:e1000341. 2009
    ..This pattern demonstrates that coat color phenotypes result from direct human selection and not via a simple relaxation of natural selective pressures...
  7. pmc ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth
    Ellen Markljung
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Biol 7:e1000256. 2009
    ....
  8. pmc Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation
    Anders R Hellström
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 7:e1002285. 2011
    ..Despite a mild effect on visible pigmentation, inactivation of Pmel led to a substantial reduction in eumelanin content in hair, which demonstrates that PMEL has a critical role for maintaining efficient epidermal pigmentation...
  9. pmc Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens
    Dominic Wright
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 5:e1000512. 2009
    ..The study provides novel insight into the nature of mutations that contribute to phenotypic evolution and is the first description of a spontaneous and fully viable mutation in this developmentally important gene...
  10. pmc A complex genomic rearrangement involving the endothelin 3 locus causes dermal hyperpigmentation in the chicken
    Ben Dorshorst
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 7:e1002412. 2011
    ..This complex genomic rearrangement causing a specific monogenic trait in the chicken illustrates how novel mutations with major phenotypic effects have been reused during breed formation in domestic animals...
  11. doi request reprint Molecular consequences of animal breeding
    Leif Andersson
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE 75123 Uppsala, Sweden
    Curr Opin Genet Dev 23:295-301. 2013
    ..An emerging feature is also the evolution of alleles by the accumulation of several consecutive mutations which affect gene function. ..
  12. pmc Heritable genome-wide variation of gene expression and promoter methylation between wild and domesticated chickens
    Daniel Nätt
    IFM Biology, Division of Zoology, Avian Behavioural Genomics and Physiology Group, Linkoping University, Sweden
    BMC Genomics 13:59. 2012
    ....
  13. ncbi request reprint Melanocortin receptor variants with phenotypic effects in horse, pig, and chicken
    Leif Andersson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    Ann N Y Acad Sci 994:313-8. 2003
    ..We could not confirm this association using an intercross between the wild boar and Large White domestic pigs, but it is possible that our F(2) generation was too small to detect the rather modest effect reported for this polymorphism...
  14. doi request reprint Studying phenotypic evolution in domestic animals: a walk in the footsteps of Charles Darwin
    L Andersson
    Department of Medical Biochemistry and Microbiology, Uppsala University, SE 75124 Uppsala, Sweden
    Cold Spring Harb Symp Quant Biol 74:319-25. 2009
    ..In a recent study, we have identified the IGF2 repressor, and this previously unknown protein, named ZBED6, is specific for placental mammals and derived from a domesticated DNA transposon...
  15. doi request reprint How selective sweeps in domestic animals provide new insight into biological mechanisms
    L Andersson
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, ppsala, Sweden
    J Intern Med 271:1-14. 2012
    ..How the molecular characterization of trait loci in domestic animals can provide new basic knowledge of relevance for human medicine is discussed...
  16. ncbi request reprint Domestic-animal genomics: deciphering the genetics of complex traits
    Leif Andersson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 597, SE 751 24 Uppsala, Sweden
    Nat Rev Genet 5:202-12. 2004
  17. pmc Mutations in SLC45A2 cause plumage color variation in chicken and Japanese quail
    Ulrika Gunnarsson
    Department of Medical Biochemistry and Microbiology, Uppsala University, SE 75124 Uppsala, Sweden
    Genetics 175:867-77. 2007
    ..It is an enigma why recessive null mutations at this locus cause an almost complete absence of both eumelanin and pheomelanin whereas some missense mutations are dominant and cause a specific inhibition of pheomelanin production...
  18. doi request reprint Expression of carnitine palmitoyl-CoA transferase-1B is influenced by a cis-acting eQTL in two chicken lines selected for high and low body weight
    Sojeong Ka
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Physiol Genomics 45:367-76. 2013
    ..The altered expression of CPT1B in hypothalamus and peripheral tissue is likely to be a mechanism contributing to the remarkable difference between lines...
  19. pmc Copy number expansion of the STX17 duplication in melanoma tissue from Grey horses
    Elisabeth Sundström
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    BMC Genomics 13:365. 2012
    ..The aims of this study were to investigate if the duplication in Grey horses shows copy number variation and to exclude that any other polymorphism is uniquely associated with the Grey mutation...
  20. ncbi request reprint Chicken genomics: feather-pecking and victim pigmentation
    Linda Keeling
    Department of Animal Environment and Health, Swedish University of Agricultural Sciences, PO Box 234, 53223 Skara, Sweden
    Nature 431:645-6. 2004
    ....
  21. doi request reprint Identification of a melanocyte-specific, microphthalmia-associated transcription factor-dependent regulatory element in the intronic duplication causing hair greying and melanoma in horses
    Elisabeth Sundström
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Pigment Cell Melanoma Res 25:28-36. 2012
    ..These results provide strong support for the causative nature of the duplication and constitute an explanation for the melanocyte-specific effects of the Grey allele...
  22. ncbi request reprint Many QTLs with minor additive effects are associated with a large difference in growth between two selection lines in chickens
    Lina Jacobsson
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, BMC, Uppsala
    Genet Res 86:115-25. 2005
    ..No QTL at all would have reached genome-wide significance using a less powerful design (e.g. approx. 200 F2 individuals) regardless of the nine-fold phenotypic difference between the founder lines for the selected trait...
  23. pmc Genetic analysis of an F(2) intercross between two chicken lines divergently selected for body-weight
    Per Wahlberg
    Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Uppsala, Sweden
    BMC Genomics 10:248. 2009
    ..Furthermore, we utilized genotype data from ~13,000 SNPs to search the genome for potential selective sweeps that have occurred in the selected lines...
  24. ncbi request reprint A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig
    Anne Sophie Van Laere
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala University, BMC, Box 597, SE 751 24 Uppsala, Sweden
    Nature 425:832-6. 2003
    ..The result supports the long-held view that regulatory mutations are important for controlling phenotypic variation...
  25. ncbi request reprint QTL analysis of body composition and metabolic traits in an intercross between chicken lines divergently selected for growth
    Hee Bok Park
    Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, Uppsala, Sweden
    Physiol Genomics 25:216-23. 2006
    ..The observed pattern indicated that these effects were caused by maternal effects or by genetic differences in mitochondrial DNA...
  26. pmc A global search reveals epistatic interaction between QTL for early growth in the chicken
    Orjan Carlborg
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, S 751 24 Uppsala, Sweden
    Genome Res 13:413-21. 2003
    ..Several of the detected loci affected either early or late growth but not both. Very few loci affected the entire growth process, which points out that early and late growth, at least to some extent, have different genetic regulation...
  27. ncbi request reprint Major growth QTLs in fowl are related to fearful behavior: possible genetic links between fear responses and production traits in a red junglefowl x white leghorn intercross
    Karin E Schütz
    Department of Animal Environment and Health, Section of Ethology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Behav Genet 34:121-30. 2004
    ..The results show that loci affecting important production traits are located in the same chromosomal region as loci affecting different fear-related behaviors...
  28. doi request reprint The Dark brown plumage color in chickens is caused by an 8.3-kb deletion upstream of SOX10
    Ulrika Gunnarsson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    Pigment Cell Melanoma Res 24:268-74. 2011
    ..Lower tyrosinase activity leads to a shift toward a more pheomelanistic (reddish) plumage color, which is the characteristic feature of the DB phenotype...
  29. pmc A missense mutation in PMEL17 is associated with the Silver coat color in the horse
    Emma Brunberg
    Dept of Medical Biochemistry and Microbiology, Uppsala University, SE 751 24 Uppsala, Sweden
    BMC Genet 7:46. 2006
    ..Herein we describe the identification of the responsible gene and a missense mutation associated with the Silver phenotype...
  30. pmc The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion polymorphisms in the PMEL17 gene
    Susanne Kerje
    Department of Medical Biochemistry and Microbiology, Uppsala University, SE 751 24 Uppsala, Sweden
    Genetics 168:1507-18. 2004
    ..These mutations are, together with the recessive silver mutation in the mouse, the only PMEL17 mutations with phenotypic effects that have been described so far in any species...
  31. pmc Differential gene expression in femoral bone from red junglefowl and domestic chicken, differing for bone phenotypic traits
    Carl Johan Rubin
    Department of Medical Sciences, Uppsala University, Sweden
    BMC Genomics 8:208. 2007
    ....
  32. ncbi request reprint Genetic analysis of metabolic traits in an intercross between body weight-selected chicken lines
    Weronica Ek
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Physiol Genomics 42:20-2. 2010
    ....
  33. ncbi request reprint Quantitative trait loci for BMD and bone strength in an intercross between domestic and wildtype chickens
    Carl Johan Rubin
    Department of Medical Sciences, Uppsala University, and Department of Internal Medicine, The Sahlgrenska University Hospital, Goteborg, Sweden
    J Bone Miner Res 22:375-84. 2007
    ..We report the identification of four QTLs for femoral traits: one for bone strength, one for endosteal circumference, and two affecting mineral density of noncortical bone...
  34. pmc A sensitive method for detecting variation in copy numbers of duplicated genes
    Gerli Pielberg
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Genome Res 13:2171-7. 2003
    ..An extensive allelic variation, including the presence of a new allele carrying a single KIT copy expected to encode a truncated KIT receptor, was revealed when analyzing white pigs from commercial lines...
  35. pmc Sonic Hedgehog-signalling patterns the developing chicken comb as revealed by exploration of the pea-comb mutation
    Henrik Boije
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    PLoS ONE 7:e50890. 2012
    ..The present study does not only give knowledge about how the chicken comb is formed, it also adds to our understanding how mutations or genetic polymorphisms may contribute to inherited variations in the human face...
  36. doi request reprint Whole-genome resequencing reveals loci under selection during chicken domestication
    Carl Johan Rubin
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE 75123 Uppsala, Sweden
    Nature 464:587-91. 2010
    ..This study has direct application to animal breeding and enhances the importance of the domestic chicken as a model organism for biomedical research...
  37. doi request reprint Differentially expressed genes in hypothalamus in relation to genomic regions under selection in two chicken lines resulting from divergent selection for high or low body weight
    Sojeong Ka
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Neurogenetics 12:211-21. 2011
    ..Because of such differential gene expression in hypothalamus, the lines may adapt behaviourally different particularly to the post-hatch situation when independent feeding to obtain energy is established...
  38. pmc Genetic architecture of tameness in a rat model of animal domestication
    Frank W Albert
    Department of Genetics and Pathology, Uppsala University, 75123 Uppsala, Sweden
    Genetics 182:541-54. 2009
    ..The loci described here are important starting points for finding the genes that cause tameness in these rats and potentially in domestic animals in general...
  39. pmc Fine mapping and replication of QTL in outbred chicken advanced intercross lines
    Francois Besnier
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Genet Sel Evol 43:3. 2011
    ..Although this approach is seen as promising, both to replicate QTL analyses and fine-map QTL, only a few AIL datasets, all originating from inbred founders, have been reported in the literature...
  40. pmc ZBED6 Modulates the Transcription of Myogenic Genes in Mouse Myoblast Cells
    Lin Jiang
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS ONE 9:e94187. 2014
    ..We propose that ZBED6 preferentially binds to active promoters and modulates transcriptional activity without recruiting repressive histone modifications. ..
  41. pmc Genome-wide identification of quantitative trait loci in a cross between Hampshire and Landrace II: meat quality traits
    Ellen Markljung
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 597, SE 751 24 Uppsala, Sweden
    BMC Genet 9:22. 2008
    ..Hampshire pigs are commonly used as the sire line in commercial pig breeding. This is the first time a pedigree including Hampshire pigs has been used for a QTL analysis of meat quality traits...
  42. ncbi request reprint Expression analysis of growth and energy regulation-associated genes in two divergent chicken strains
    Sojeong Ka
    Department of Neuroscience, Uppsala University, Sweden
    Ann N Y Acad Sci 1040:357-9. 2005
    ..Several transcripts from genes in metabolic networks as well as from retroviruses were differentially expressed...
  43. pmc A novel unstable duplication upstream of HAS2 predisposes to a breed-defining skin phenotype and a periodic fever syndrome in Chinese Shar-Pei dogs
    Mia Olsson
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 7:e1001332. 2011
    ..The identification of HA as a major risk factor for this canine disease raises the potential of this glycosaminoglycan as a risk factor for human periodic fevers and as an important driver of chronic inflammation...
  44. pmc Transcription factor ZBED6 affects gene expression, proliferation, and cell death in pancreatic beta cells
    Xuan Wang
    Science for Life Laboratory, Department of Medical Cell Biology, and Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, SE 75123 Uppsala, Sweden
    Proc Natl Acad Sci U S A 110:15997-6002. 2013
    ..Furthermore, it is possible that beta cells, by switching from full length to a truncated form of ZBED6, can decide the subcellular localization of ZBED6, thereby achieving differential ZBED6-mediated transcriptional regulation. ..
  45. ncbi request reprint Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs
    Nicolette H C Salmon Hillbertz
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences SLU, Biomedical Centre, Box 597, SE 751 24 Uppsala, Sweden
    Nat Genet 39:1318-20. 2007
    ..FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development...
  46. ncbi request reprint High-resolution comparative mapping of pig Chromosome 4, emphasizing the FAT1 region
    Maria Moller
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, 75124, Uppsala, Sweden
    Mamm Genome 15:717-31. 2004
    ..This refined SSC4 map and the comparative analysis will be a great aid in the search for the genes underlying the FAT1 locus...
  47. doi request reprint Modelling of genetic interactions improves prediction of hybrid patterns--a case study in domestic fowl
    José M Alvarez-Castro
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Genet Res (Camb) 94:255-66. 2012
    ..This observation coincides with the hypothesis that hybridization tends to break up co-adapted gene complexes, i.e. generate Bateson-Dobzhansky-Muller incompatibilities...
  48. pmc Proviral integrations and expression of endogenous avian leucosis virus during long term selection for high and low body weight in two chicken lines
    Sojeong Ka
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Retrovirology 6:68. 2009
    ..The main differentially expressed transcripts were endogenous retroviral sequences identified as avian leucosis virus subgroup-E (ALVE)...
  49. pmc Strong signatures of selection in the domestic pig genome
    Carl Johan Rubin
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, SE 751 23 Uppsala, Sweden
    Proc Natl Acad Sci U S A 109:19529-36. 2012
    ....
  50. doi request reprint Mapping QTL affecting a systemic sclerosis-like disorder in a cross between UCD-200 and red jungle fowl chickens
    Weronica Ek
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Dev Comp Immunol 38:352-9. 2012
    ..These results illustrate the usefulness of the UCD-200 chicken as a model of human SSc and motivate further in-depth functional studies of the implicated candidate genes...
  51. pmc Refined localization of the FAT1 quantitative trait locus on pig chromosome 4 by marker-assisted backcrossing
    Frida Berg
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, SE 751 24, Sweden
    BMC Genet 7:17. 2006
    ..In order to narrow down the QTL interval we have traced the inheritance of the wild boar allele associated with high fat deposition through six additional backcross generations...
  52. doi request reprint Sex-linked barring in chickens is controlled by the CDKN2A /B tumour suppressor locus
    Anders R Hellström
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    Pigment Cell Melanoma Res 23:521-30. 2010
    ..This novel finding provides the first evidence that the tumour suppressor locus CDKN2A/B can affect pigmentation phenotypes and sheds new light on the functional significance of this gene...
  53. ncbi request reprint A large duplication associated with dominant white color in pigs originated by homologous recombination between LINE elements flanking KIT
    Elisabetta Giuffra
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, S 751 24 Uppsala, Sweden
    Mamm Genome 13:569-77. 2002
    ....
  54. doi request reprint A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse
    Gerli Rosengren Pielberg
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 597, SE 751 24 Uppsala, Sweden
    Nat Genet 40:1004-9. 2008
    ..The Gray horse provides a notable example of how humans have cherry-picked mutations with favorable phenotypic effects in domestic animals...
  55. ncbi request reprint QTL analysis of a red junglefowl x White Leghorn intercross reveals trade-off in resource allocation between behavior and production traits
    Karin Schutz
    Swedish University of Agricultural Sciences, Department of Animal Environment and Health, Section of Ethology, POB 234, SE 532 23 Skara, Sweden
    Behav Genet 32:423-33. 2002
    ..The results suggest a trade-off between energy-demanding behavior and high production and that some of this may be caused by genetic linkage or pleiotropic gene effects...
  56. ncbi request reprint Epistasis and the release of genetic variation during long-term selection
    Orjan Carlborg
    Linnaeus Centre for Bioinformatics, Uppsala University, Box 598, SE 75124 Uppsala, Sweden
    Nat Genet 38:418-20. 2006
    ..The interactions in this radial network mediate a considerably larger selection response than predicted by a single-locus model...
  57. ncbi request reprint Gene copy number detection in animal studies
    Gerli Pielberg
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    Methods Mol Biol 373:147-56. 2007
    ..We also discuss our method for determining the copy numbers at a duplicated locus. This method has been applied to study genetic variation at the KIT locus in pigs, which have a major effect on coat color variation in this species...
  58. pmc ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions
    Alexander Hayward
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e59940. 2013
    ..Our results offer new insights into the evolution of regulatory pathways, and suggest that DNA transposons have contributed to regulatory complexity during genome evolution in vertebrates...
  59. ncbi request reprint Comparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs
    Valerie Amarger
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, SE 751 24 Uppsala, Sweden
    Mamm Genome 13:388-98. 2002
    ..The high GC and CpG content were more pronounced in the pig than in the two other species. The results will facilitate the further characterization of this important QTL in the pig...
  60. pmc Population-scale sequencing reveals genetic differentiation due to local adaptation in Atlantic herring
    Sangeet Lamichhaney
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, SE 75123 Uppsala, Sweden
    Proc Natl Acad Sci U S A 109:19345-50. 2012
    ..This study provides insights concerning the population structure of an important marine fish and establishes the Atlantic herring as a model for population genetic studies of adaptation and natural selection...
  61. pmc Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice
    Lisa S Andersson
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, SE 75124 Uppsala, Sweden
    Nature 488:642-6. 2012
    ..The DMRT3 mutation has had a major effect on the diversification of the domestic horse, as the altered gait characteristics of a number of breeds apparently require this mutation...
  62. pmc A nonsense mutation in the FMO3 gene underlies fishy off-flavor in cow's milk
    Anne Lundén
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Genome Res 12:1885-8. 2002
    ..RT-PCR analysis indicated that the mutant transcript is present in a very low amount. The mutation was found to be surprisingly common (q = 0.155) in one breed of cattle...
  63. pmc The uncoupling protein 1 gene (UCP1) is disrupted in the pig lineage: a genetic explanation for poor thermoregulation in piglets
    Frida Berg
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 2:e129. 2006
    ....
  64. ncbi request reprint Use of randomization testing to detect multiple epistatic QTLs
    Orjan Carlborg
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, BMC, Box 597, S 751 24 Uppsala, Sweden
    Genet Res 79:175-84. 2002
    ..We believe that this method will facilitate the evaluation of the importance at epistatic interaction among QTLs controlling multifactorial traits and disorders...
  65. pmc Mitochondrial diversity in European and Chinese pigs is consistent with population expansions that occurred prior to domestication
    Meiying Fang
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Proc Biol Sci 273:1803-10. 2006
    ..Mismatch analysis supported this notion and suggested that the expansion was initiated before domestication...
  66. ncbi request reprint Effect of exercise on proglycogen and macroglycogen content in skeletal muscles of pigs with the Rendement Napole mutation
    Birgitta Essen-Gustavsson
    Department of Clinical Sciences, Section for Comparative Physiology and Medicine, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, S 750 07, Uppsala, Sweden
    Am J Vet Res 66:1197-201. 2005
    ..To investigate influence of the Rendement Napole (RN-) mutation on proglycogen (PG) and macroglycogen (MG) content in skeletal muscles before and after exercise and evaluate glycogen concentrations within various muscle fiber types...
  67. ncbi request reprint Efficient mapping of mendelian traits in dogs through genome-wide association
    Elinor K Karlsson
    Broad Institute of Harvard and Massachusetts Institute of Technology MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1321-8. 2007
    ....
  68. ncbi request reprint [Studies of relationship between the melanocortin-3 receptor gene and body weight in chicken for high and low weight lines' intercross]
    Si Wen Jiang
    Huazhong Agricultural University, Wuhan 430070, China
    Yi Chuan Xue Bao 29:322-5. 2002
    ..The result suggests that the MC3R as a candidate gene can explain significant difference for body weight in the intercross chickens...
  69. pmc A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms
    Gane Ka Shu Wong
    Beijing Institute of Genomics of Chinese Academy of Sciences, Beijing Genomics Institute, Beijing Proteomics Institute, Beijing 101300, China
    Nature 432:717-22. 2004
    ..In fact, most of the SNPs originated before domestication, and there is little evidence of selective sweeps for adaptive alleles on length scales greater than 100 kilobases...
  70. ncbi request reprint The genetic architecture of a female sexual ornament
    Dominic Wright
    Edward Grey Institute, Department of Zoology, University of Oxford, Oxford, UK
    Evolution 62:86-98. 2008
    ..Together, these results shed light onto the physiological and genetic architecture of a female ornament...
  71. ncbi request reprint Plumage color and feather pecking--behavioral differences associated with PMEL17 genotypes in chicken (Gallus gallus)
    Daniel Nätt
    Department of Biology IFM, Linkoping University, SE 58183, Linkoping, Sweden
    Behav Genet 37:399-407. 2007
    ..Such behavioral differences might be important aspects of the mechanism which predispose i/i individuals for being victims of FP...
  72. ncbi request reprint Genomics meets ethology: a new route to understanding domestication, behavior, and sustainability in animal breeding
    Per Jensen
    Department of Biology, IFM, Linkoping University, Sweden
    Ambio 34:320-4. 2005
    ..Modern genomics paired with analysis of behavior may help in designing more sustainable and robust breeding in the future...
  73. ncbi request reprint Genetic analysis of anal atresia in pigs: evidence for segregation at two main loci
    Pamela Cassini
    Parco Tecnologico Padano, Centro Ricerche Studi Agroalimentari, Polo Universitario, via A Einstein 2, 26900, Lodi, Italy
    Mamm Genome 16:164-70. 2005
    ..GLI2 (GLI-Kruppel family member GLI2) was identified as a positional candidate gene based on comparative mapping; radiation hybrid mapping confirmed that this locus is located within the QTL region...
  74. ncbi request reprint The IGF2-intron3-G3072A substitution explains a major imprinted QTL effect on backfat thickness in a Meishan x European white pig intercross
    Bart J Jungerius
    Department of Animal Breeding and Genetics, Wageningen University, P O Box 40, 6700 AH Wageningen, The Netherlands
    Genet Res 84:95-101. 2004
    ..Finally, this study shows that this particular IGF2 mutation does not cause the paternally expressed QTL for teat number mapping to the same region of SSC2p as the BFT QTL...
  75. pmc Haplotype sharing refines the location of an imprinted quantitative trait locus with major effect on muscle mass to a 250-kb chromosome segment containing the porcine IGF2 gene
    Carine Nezer
    Department of Genetics, Faculty of Veterinary Medicine, University of Liege, 4000 Liege, Belgium
    Genetics 165:277-85. 2003
    ..This considerably reinforces the candidacy of these genes, justifying their detailed analysis...
  76. ncbi request reprint The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle
    Brian R Barnes
    Department of Surgical Sciences and the Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Biol Chem 279:38441-7. 2004
    ..Our results validate the muscle-specific AMPK gamma3 isoform as a therapeutic target for prevention and treatment of insulin resistance...
  77. ncbi request reprint Worldwide phylogeography of wild boar reveals multiple centers of pig domestication
    Greger Larson
    Henry Wellcome Ancient Biomolecules Centre, University of Oxford, Department of Zoology, South Parks Road OX1 3PS, UK
    Science 307:1618-21. 2005
    ..In contrast, new genetic data reveal multiple centers of domestication across Eurasia and that European, rather than Near Eastern, wild boar are the principal source of modern European domestic pigs...
  78. pmc Estimating the frequency of Asian cytochrome B haplotypes in standard European and local Spanish pig breeds
    Alex Clop
    , , , Bellaterra 08193, Spain
    Genet Sel Evol 36:97-104. 2004
    ..These findings illustrate how geographical confinement spared several local Spanish breeds from the extensive introgression event that took place during the 18th and 19th centuries in Europe...
  79. pmc Avian models with spontaneous autoimmune diseases
    Georg Wick
    Division of Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Adv Immunol 92:71-117. 2006
    ..Special emphasis is given to the new opportunities to unravel the genetic basis of these diseases in view of the recently completed sequencing of the chicken genome...
  80. ncbi request reprint The mutation causing the black-and-tan pigmentation phenotype of Mangalitza pigs maps to the porcine ASIP locus but does not affect its coding sequence
    Cord Drogemuller
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, 30559, Germany
    Mamm Genome 17:58-66. 2006
    ..The a(t) mutation is therefore probably a regulatory ASIP mutation that alters its dorsoventral expression pattern...