Inger Andersson

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. pmc Purification and kinetic studies of recombinant gibberellin dioxygenases
    Diane R Lester
    Institute for Cell and Molecular Biology, Uppsala University, 751 24 Uppsala, Sweden
    BMC Plant Biol 5:19. 2005
  2. ncbi request reprint Structural framework for catalysis and regulation in ribulose-1,5-bisphosphate carboxylase/oxygenase
    Inger Andersson
    Department of Molecular Biology, Swedish University of Agricultural Sciences, BMC Box 590, S 751 24, Uppsala, Sweden
    Arch Biochem Biophys 414:130-40. 2003
  3. ncbi request reprint Catalysis and regulation in Rubisco
    Inger Andersson
    Department of Molecular Biology, Swedish University of Agricultural Sciences, BMC Box 590, S 751 24 Uppsala, Sweden
    J Exp Bot 59:1555-68. 2008
  4. doi request reprint Structure and function of Rubisco
    Inger Andersson
    Department of Molecular Biology, Swedish University of Agricultural Sciences, Husargatan 3, BMC Box 590, S 751 24 Uppsala, Sweden
    Plant Physiol Biochem 46:275-91. 2008
  5. ncbi request reprint Conformational flexibility of the C terminus with implications for substrate binding and catalysis revealed in a new crystal form of deacetoxycephalosporin C synthase
    Linda M Oster
    Department of Molecular Biology, Swedish University of Agricultural Sciences, Box 590, S 75124 Uppsala
    J Mol Biol 343:157-71. 2004
  6. ncbi request reprint Insights into cephamycin biosynthesis: the crystal structure of CmcI from Streptomyces clavuligerus
    Linda M Oster
    Department of Molecular Biology, Swedish University of Agricultural Sciences, Box 590, S 751 24 Uppsala, Sweden
    J Mol Biol 358:546-58. 2006
  7. ncbi request reprint Structural analysis of altered large-subunit loop-6/carboxy-terminus interactions that influence catalytic efficiency and CO2/O2 specificity of ribulose-1,5-bisphosphate carboxylase/oxygenase
    Saeid Karkehabadi
    Department of Molecular Biology, Swedish University of Agricultural Sciences, BMC Box 590, 751 24 Uppsala, Sweden
    Biochemistry 46:11080-9. 2007
  8. doi request reprint Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway
    Karin Valegård
    Department of Molecular Biology, Swedish University of Agricultural Sciences, Box 590, S 751 24 Uppsala, Sweden
    Acta Crystallogr D Biol Crystallogr 69:1567-79. 2013
  9. ncbi request reprint Chimeric small subunits influence catalysis without causing global conformational changes in the crystal structure of ribulose-1,5-bisphosphate carboxylase/oxygenase
    Saeid Karkehabadi
    Department of Molecular Biology, Swedish University of Agricultural Sciences, 751 24 Uppsala, Sweden
    Biochemistry 44:9851-61. 2005
  10. doi request reprint Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid
    Alasdair K MacKenzie
    Department of Molecular Biology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    J Mol Biol 396:332-44. 2010

Collaborators

Detail Information

Publications21

  1. pmc Purification and kinetic studies of recombinant gibberellin dioxygenases
    Diane R Lester
    Institute for Cell and Molecular Biology, Uppsala University, 751 24 Uppsala, Sweden
    BMC Plant Biol 5:19. 2005
    ..The activity of recombinant GA 2ODDs from many species has been characterised in detail, however little information relates to enzyme purification. Native GA 2ODDs displayed lability during purification...
  2. ncbi request reprint Structural framework for catalysis and regulation in ribulose-1,5-bisphosphate carboxylase/oxygenase
    Inger Andersson
    Department of Molecular Biology, Swedish University of Agricultural Sciences, BMC Box 590, S 751 24, Uppsala, Sweden
    Arch Biochem Biophys 414:130-40. 2003
    ..This article gives a critical review of the field and summarizes recent results from structural studies of Rubisco...
  3. ncbi request reprint Catalysis and regulation in Rubisco
    Inger Andersson
    Department of Molecular Biology, Swedish University of Agricultural Sciences, BMC Box 590, S 751 24 Uppsala, Sweden
    J Exp Bot 59:1555-68. 2008
    ..Numerous high-resolution crystal structures of different forms of Rubisco are now available, including structures of mutant enzymes. These provide a molecular framework for the understanding of these processes at the molecular level...
  4. doi request reprint Structure and function of Rubisco
    Inger Andersson
    Department of Molecular Biology, Swedish University of Agricultural Sciences, Husargatan 3, BMC Box 590, S 751 24 Uppsala, Sweden
    Plant Physiol Biochem 46:275-91. 2008
    ....
  5. ncbi request reprint Conformational flexibility of the C terminus with implications for substrate binding and catalysis revealed in a new crystal form of deacetoxycephalosporin C synthase
    Linda M Oster
    Department of Molecular Biology, Swedish University of Agricultural Sciences, Box 590, S 75124 Uppsala
    J Mol Biol 343:157-71. 2004
    ..An analysis of the interactions between the C-terminal region and residues in the active site indicates that DAOCS could also accept polypeptide chains as ligands, and these could bind near the iron...
  6. ncbi request reprint Insights into cephamycin biosynthesis: the crystal structure of CmcI from Streptomyces clavuligerus
    Linda M Oster
    Department of Molecular Biology, Swedish University of Agricultural Sciences, Box 590, S 751 24 Uppsala, Sweden
    J Mol Biol 358:546-58. 2006
    ..In this model, the 7-hydroxy group of the beta-lactam ring ligates the Mg2+ with its alpha-side facing the methyl group of SAM at a distance that would allow methylation of the hydroxyl-group...
  7. ncbi request reprint Structural analysis of altered large-subunit loop-6/carboxy-terminus interactions that influence catalytic efficiency and CO2/O2 specificity of ribulose-1,5-bisphosphate carboxylase/oxygenase
    Saeid Karkehabadi
    Department of Molecular Biology, Swedish University of Agricultural Sciences, BMC Box 590, 751 24 Uppsala, Sweden
    Biochemistry 46:11080-9. 2007
    ..However, active-site Lys334 at the apex of loop 6 has a normal conformation. A variety of subtle interactions must be responsible for catalytic efficiency and CO2/O2 specificity...
  8. doi request reprint Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway
    Karin Valegård
    Department of Molecular Biology, Swedish University of Agricultural Sciences, Box 590, S 751 24 Uppsala, Sweden
    Acta Crystallogr D Biol Crystallogr 69:1567-79. 2013
    ..The role of ORF12 in clavulanic acid biosynthesis is unknown, but it may be involved in the epimerization of (3S,5S)-clavaminic acid to (3R,5R)-clavulanic acid. ..
  9. ncbi request reprint Chimeric small subunits influence catalysis without causing global conformational changes in the crystal structure of ribulose-1,5-bisphosphate carboxylase/oxygenase
    Saeid Karkehabadi
    Department of Molecular Biology, Swedish University of Agricultural Sciences, 751 24 Uppsala, Sweden
    Biochemistry 44:9851-61. 2005
    ..This loop may be a worthwhile target for genetic engineering aimed at improving photosynthetic CO(2) fixation...
  10. doi request reprint Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid
    Alasdair K MacKenzie
    Department of Molecular Biology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    J Mol Biol 396:332-44. 2010
    ..The crystal structures of OppA2 in complex with arginine or bradykinin reveal that the C-terminal arginine of bradykinin binds similarly to arginine. The results are discussed in terms of the possible roles of OppA1/2 in CA biosynthesis...
  11. ncbi request reprint Altered intersubunit interactions in crystal structures of catalytically compromised ribulose-1,5-bisphosphate carboxylase/oxygenase
    Saeid Karkehabadi
    Department of Molecular Biology, Swedish University of Agricultural Sciences, BMC Box 590, 751 24 Uppsala, Sweden
    Biochemistry 44:113-20. 2005
    ..This suggests that alterations in subunit interactions will influence protein dynamics and, thereby, affect catalysis...
  12. pmc Structure of the homodimeric glycine decarboxylase P-protein from Synechocystis sp. PCC 6803 suggests a mechanism for redox regulation
    Dirk Hasse
    From the Department of Cell and Molecular Biology, Uppsala University, S 751 24 Uppsala, Sweden
    J Biol Chem 288:35333-45. 2013
    ..The observation of the disulfide bond that acts to stabilize the closed form suggests a molecular mechanism for the redox-dependent activation of glycine decarboxylase observed earlier. ..
  13. ncbi request reprint Subunit interface dynamics in hexadecameric rubisco
    Michiel van Lun
    Department of Molecular Biology, Swedish University of Agricultural Sciences, Box 590, S 75124 Uppsala, Sweden
    J Mol Biol 411:1083-98. 2011
    ..These checkpoints appear to fine-tune the dynamics of the enzyme in a way that could influence enzyme performance...
  14. ncbi request reprint Clavulanic acid dehydrogenase: structural and biochemical analysis of the final step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid
    Alasdair K MacKenzie
    Department of Molecular Biology, Swedish University of Agricultural Sciences, Box 590, S 751 24 Uppsala, Sweden
    Biochemistry 46:1523-33. 2007
    ....
  15. ncbi request reprint MIR phasing using merohedrally twinned crystals
    Anke C Terwisscha van Scheltinga
    Department of Molecular Biology, Swedish University of Agricultural Sciences, Box 590, S 751 24 Uppsala, Sweden
    Acta Crystallogr D Biol Crystallogr 59:2017-22. 2003
    ..It seems more crucial to restrict the variation in twin fractions between data sets, either by making the twin fractions of some data sets artificially higher or by screening crystals to obtain data with a low twin fraction...
  16. ncbi request reprint Expression, purification, crystallization and preliminary X-ray diffraction studies of the cmcI component of Streptomyces clavuligerus 7alpha-cephem-methoxylase
    Diane R Lester
    Department of Cell and Molecular Biology, Uppsala University, Box 596, S 751 24 Uppsala, Sweden
    Acta Crystallogr D Biol Crystallogr 60:1618-21. 2004
    ..The crystals belong to space group P2(1), with unit-cell parameters a = 93.6, b = 182.6, c = 103.2 A, beta = 91.05 degrees. Diffraction data were collected to 2.5 A...
  17. ncbi request reprint CO2 and O2 distribution in Rubisco suggests the small subunit functions as a CO2 reservoir
    Michiel van Lun
    Department of Molecular Biology, Swedish University of Agricultural Sciences, Box 590, S 751 24 Uppsala, Sweden
    J Am Chem Soc 136:3165-71. 2014
    ..Taken together, these results suggest the small subunit may function as a "reservoir" for CO2 storage. ..
  18. ncbi request reprint The structural basis of cephalosporin formation in a mononuclear ferrous enzyme
    Karin Valegård
    Molecular Biophysics, Department of Cellular and Molecular Biology, Uppsala University, Box 596, S 751 24 Uppsala, Sweden
    Nat Struct Mol Biol 11:95-101. 2004
    ..Requisite groups of penicillin are within 1 A of the expected position of a ferryl oxygen in the enzyme-penicillin complex...
  19. ncbi request reprint Calcium supports loop closure but not catalysis in Rubisco
    Saeid Karkehabadi
    Department of Molecular Biosciences, Swedish University of Agricultural Sciences, BMC Box 590, S 751 24, Uppsala, Sweden
    J Mol Biol 334:65-73. 2003
    ..Similar effects are also expected on subsequent proton transfer steps in the catalytic cycle. Here we also discuss the effect of metal substitution on the dynamics of the ligands around the metal ion...
  20. pmc Structure and mutational analysis of a plant mitochondrial nucleoside diphosphate kinase. Identification of residues involved in serine phosphorylation and oligomerization
    Monika Johansson
    Department of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, S 750 07 Uppsala, Sweden
    Plant Physiol 136:3034-42. 2004
    ..We conclude that the S69 mutant is involved in the stabilization of the oligomeric state of this plant nucleoside diphosphate kinase...
  21. ncbi request reprint Structural and functional consequences of the replacement of proximal residues Cys(172) and Cys(192) in the large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase from Chlamydomonas reinhardtii
    María Jesús García-Murria
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Valencia, Av Dr Moliner 50, Burjassot, València E 46100, Spain
    Biochem J 411:241-7. 2008
    ..This may cause the exceptional catalytic features of C172S. In contrast, the C192S mutation does not produce similar structural perturbations...