D I Andersson

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. doi request reprint Antibiotic resistance and its cost: is it possible to reverse resistance?
    Dan I Andersson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE 751 23, Uppsala, Sweden
    Nat Rev Microbiol 8:260-71. 2010
  2. pmc Dynamics of antibiotic resistant Mycobacterium tuberculosis during long-term infection and antibiotic treatment
    Solomon H Mariam
    Swedish Institute for Infectious Disease Control, Solna, Sweden
    PLoS ONE 6:e21147. 2011
  3. pmc Pathoadaptive mutations in Salmonella enterica isolated after serial passage in mice
    Sanna Koskiniemi
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e70147. 2013
  4. pmc Selection-driven gene loss in bacteria
    Sanna Koskiniemi
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 8:e1002787. 2012
  5. pmc Selection of resistant bacteria at very low antibiotic concentrations
    Erik Gullberg
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Pathog 7:e1002158. 2011
  6. pmc Genome-wide detection of spontaneous chromosomal rearrangements in bacteria
    Song Sun
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS ONE 7:e42639. 2012
  7. pmc Fitness costs of synonymous mutations in the rpsT gene can be compensated by restoring mRNA base pairing
    Peter A Lind
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e63373. 2013
  8. pmc Mechanisms and fitness costs of resistance to antimicrobial peptides LL-37, CNY100HL and wheat germ histones
    Hava Lofton
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e68875. 2013
  9. doi request reprint Evolution of antibiotic resistance at non-lethal drug concentrations
    Dan I Andersson
    Department of Medical Biochemistry and Microbiology, Box 582, SE 75123 Uppsala, Sweden
    Drug Resist Updat 15:162-72. 2012
  10. doi request reprint Gene amplification and adaptive evolution in bacteria
    Dan I Andersson
    Department of Medical Biochemistry and Microbiology, Uppsala, S 751 23, Sweden
    Annu Rev Genet 43:167-95. 2009

Collaborators

Detail Information

Publications53

  1. doi request reprint Antibiotic resistance and its cost: is it possible to reverse resistance?
    Dan I Andersson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE 751 23, Uppsala, Sweden
    Nat Rev Microbiol 8:260-71. 2010
    ..Here, we review the factors that influence the fitness costs of antibiotic resistance, the ways by which bacteria can reduce these costs and the possibility of exploiting them...
  2. pmc Dynamics of antibiotic resistant Mycobacterium tuberculosis during long-term infection and antibiotic treatment
    Solomon H Mariam
    Swedish Institute for Infectious Disease Control, Solna, Sweden
    PLoS ONE 6:e21147. 2011
    ..These findings have important implications for diagnostics and treatment of drug resistant tuberculosis infections...
  3. pmc Pathoadaptive mutations in Salmonella enterica isolated after serial passage in mice
    Sanna Koskiniemi
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e70147. 2013
    ..These experiments show that Salmonella can rapidly adapt to a mouse environment by acquiring a few mutations of moderate individual effect that when combined confer substantial increases in growth. ..
  4. pmc Selection-driven gene loss in bacteria
    Sanna Koskiniemi
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 8:e1002787. 2012
    ..These results suggest that selection could be a significant driver of gene loss and reductive genome evolution...
  5. pmc Selection of resistant bacteria at very low antibiotic concentrations
    Erik Gullberg
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Pathog 7:e1002158. 2011
    ..These results add another dimension to the evolution of resistance and suggest that the low antibiotic concentrations found in many natural environments are important for enrichment and maintenance of resistance in bacterial populations...
  6. pmc Genome-wide detection of spontaneous chromosomal rearrangements in bacteria
    Song Sun
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS ONE 7:e42639. 2012
    ..This study demonstrates the feasibility of genome wide characterization of spontaneous genome rearrangements in bacteria and the very high steady-state frequency (20-40%) of rearrangements in bacterial populations...
  7. pmc Fitness costs of synonymous mutations in the rpsT gene can be compensated by restoring mRNA base pairing
    Peter A Lind
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e63373. 2013
    ..These results suggest that for ribosomal protein S20, the deleterious effects of synonymous mutations are not generally due to codon usage effects, but that mRNA secondary structure is a major fitness constraint...
  8. pmc Mechanisms and fitness costs of resistance to antimicrobial peptides LL-37, CNY100HL and wheat germ histones
    Hava Lofton
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e68875. 2013
    ..These results suggest that resistant mutants could both be selected de novo and maintained by exposure to our own natural repertoire of defence molecules. ..
  9. doi request reprint Evolution of antibiotic resistance at non-lethal drug concentrations
    Dan I Andersson
    Department of Medical Biochemistry and Microbiology, Box 582, SE 75123 Uppsala, Sweden
    Drug Resist Updat 15:162-72. 2012
    ..Such conditions may occur during antibiotic therapy or in anthropogenically drug-polluted natural environments. Non-lethal selection increases rates of mutant appearance and promotes enrichment of highly fit mutants and stable mutators...
  10. doi request reprint Gene amplification and adaptive evolution in bacteria
    Dan I Andersson
    Department of Medical Biochemistry and Microbiology, Uppsala, S 751 23, Sweden
    Annu Rev Genet 43:167-95. 2009
    ..Due to the high intrinsic instability and fitness costs associated with GDAs, they are generally transient in nature, and consequently their evolutionary and medical importance is often underestimated...
  11. doi request reprint Biological roles of translesion synthesis DNA polymerases in eubacteria
    Dan I Andersson
    Uppsala University, Department of Medical Biochemistry and Microbiology, SE 75123 Uppsala, Sweden
    Mol Microbiol 77:540-8. 2010
    ....
  12. ncbi request reprint The biological cost of mutational antibiotic resistance: any practical conclusions?
    Dan I Andersson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, S 751 23 Uppsala, Sweden
    Curr Opin Microbiol 9:461-5. 2006
    ..Conceivably we can use this knowledge to rationally choose and design targets and drugs where the costs of resistance are the highest, and where the likelihood of compensation is the lowest...
  13. doi request reprint Persistence of antibiotic resistance in bacterial populations
    Dan I Andersson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    FEMS Microbiol Rev 35:901-11. 2011
    ..Several mechanisms are contributing to the stability of antibiotic resistance in bacterial populations and even if antibiotic use is reduced it is likely that most resistance mechanisms will persist for considerable times...
  14. doi request reprint Bacterial gene amplification: implications for the evolution of antibiotic resistance
    Linus Sandegren
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, Uppsala, S751 23, Sweden
    Nat Rev Microbiol 7:578-88. 2009
    ..In this Review, we highlight the dynamic properties of gene amplifications and describe how they can facilitate adaptive evolution in response to toxic drugs...
  15. ncbi request reprint An adenosyl-cobalamin (coenzyme-B12)-repressed translational enhancer in the cob mRNA of Salmonella typhimurium
    S Ravnum
    Department of Cell and Molecular Biology, Uppsala University, S-751 24 Uppsala, Sweden
    Mol Microbiol 39:1585-94. 2001
    ..The above data suggest that normal cobalamin repression of the cob operon requires that the 5'-UTR has a defined secondary and tertiary structure...
  16. pmc Contribution of gene amplification to evolution of increased antibiotic resistance in Salmonella typhimurium
    Song Sun
    Department of Medical Biochemistry and Microbiology, Uppsala University, S 75123, Sweden
    Genetics 182:1183-95. 2009
    ..If later point mutations (allowed by amplification) provide sufficient adaptive improvement, the amplification may be lost...
  17. pmc Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2
    Maria Pränting
    Department of Medical Biochemistry and Microbiology, Uppsala University, S 751 23 Uppsala, Sweden
    Antimicrob Agents Chemother 52:2734-41. 2008
    ....
  18. doi request reprint Compensatory gene amplification restores fitness after inter-species gene replacements
    Peter A Lind
    Department of Medical Biochemistry and Microbiology, Uppsala University, SE 75123 Uppsala, Sweden
    Mol Microbiol 75:1078-89. 2010
    ..Our findings can explain the observation that duplicated genes are over-represented among horizontally transferred genes, and suggest a potential coupling between compensatory gene amplification after HGT and the evolution of new genes...
  19. pmc Error-prone initiation factor 2 mutations reduce the fitness cost of antibiotic resistance
    Anna Zorzet
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE 751 23 Uppsala, Sweden
    Mol Microbiol 75:1299-313. 2010
    ..More generally, our results suggest that bacterial protein synthesis is mRNA-limited and that compensatory mutations in IF2 could increase the persistence of PDFI-resistant bacteria in clinical settings...
  20. pmc Genetic analysis of colistin resistance in Salmonella enterica serovar Typhimurium
    Song Sun
    Department of Medical Biochemistry and Microbiology, Uppsala University, S 751 23 Uppsala, Sweden
    Antimicrob Agents Chemother 53:2298-305. 2009
    ..The low fitness costs and the high mutation rate suggest that mutants with reduced susceptibility to colistin could emerge in clinical settings...
  21. pmc Fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium with low fitness in vivo are defective in RpoS induction
    Mirjana Macvanin
    Department of Cell and Molecular Biology, The Biomedical Center, Uppsala University, S 751 24 Uppsala, Sweden
    Antimicrob Agents Chemother 47:3743-9. 2003
    ..The low fitness of Fusr mutants in vivo suggests that drugs that can alter the levels of global regulators of gene expression deserve attention as potential antimicrobial agents...
  22. pmc Effect of translesion DNA polymerases, endonucleases and RpoS on mutation rates in Salmonella typhimurium
    Sanna Koskiniemi
    Department of Cell and Molecular Biology, Uppsala University, S 75123 Uppsala, Sweden
    Genetics 185:783-95. 2010
    ....
  23. doi request reprint Little evidence for reversibility of trimethoprim resistance after a drastic reduction in trimethoprim use
    M Sundqvist
    Department of Medical Sciences, Section of Infectious Diseases, Uppsala University Hospital, Uppsala University, S 751 85 Uppsala, Sweden
    J Antimicrob Chemother 65:350-60. 2010
    ..Resistance may thus be reversible if antibiotic use is discontinued or reduced. To examine this concept, we performed a 24 month voluntary restriction on the use of trimethoprim-containing drugs in Kronoberg County, Sweden...
  24. ncbi request reprint Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium
    J Bjorkman
    Department of Microbiology, Uppsala University, Sweden
    Mol Microbiol 31:53-8. 1999
    ..This is the first demonstration that such compensations do not require that the compensating rpsD allele has a ribosomal ambiguity (ram) phenotype...
  25. pmc The fitness cost of streptomycin resistance depends on rpsL mutation, carbon source and RpoS (sigmaS)
    Wilhelm Paulander
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    Genetics 183:539-46, 1SI-2SI. 2009
    ....
  26. ncbi request reprint Long-term persistence of resistant Enterococcus species after antibiotics to eradicate Helicobacter pylori
    Maria Sjolund
    University Hospital Uppsala, Uppsala, Sweden
    Ann Intern Med 139:483-7. 2003
    ..Antibiotic treatment selects for resistance not only in the pathogen to which it is directed but also in the indigenous microflora...
  27. doi request reprint Mechanisms and physiological effects of protamine resistance in Salmonella enterica serovar Typhimurium LT2
    Maria Pränting
    Department of Medical Biochemistry and Microbiology, Uppsala University, SE 751 23 Uppsala, Sweden
    J Antimicrob Chemother 65:876-87. 2010
    ....
  28. doi request reprint Evolution of new gene functions: simulation and analysis of the amplification model
    Mats E Pettersson
    Department of Molecular Evolution, Evolutionary Biology Centre, Uppsala University, Uppsala, SE 752 36, Sweden
    Genetica 135:309-24. 2009
    ..The results show that amplification of tandem repeats is likely to contribute to creation of new genes in nature...
  29. pmc Persistence of resistant Staphylococcus epidermidis after single course of clarithromycin
    Maria Sjolund
    University Hospital, Uppsala, Sweden
    Emerg Infect Dis 11:1389-93. 2005
    ..We show that macrolide-resistant strains of S. epidermidis were selected during therapy and that the same resistant strain may persist for 4 years, in the absence of further antimicrobial treatment...
  30. pmc Translesion DNA polymerases are required for spontaneous deletion formation in Salmonella typhimurium
    Sanna Koskiniemi
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    Proc Natl Acad Sci U S A 106:10248-53. 2009
    ..These findings suggest that the translesion polymerases are not involved in forming the DNA breaks, but that they require them to stimulate deletion formation...
  31. ncbi request reprint Antibiotic treatment in vitro of phenotypically tolerant bacterial populations
    Camilla Wiuff
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, S 751 23 Uppsala, Sweden
    J Antimicrob Chemother 59:254-63. 2007
    ..We compared the microbiological efficacy of six antibiotics against tolerant cells and by mathematical modelling explored the potential clinical implications of tolerance...
  32. ncbi request reprint Bacteria with increased mutation frequency and antibiotic resistance are enriched in the commensal flora of patients with high antibiotic usage
    Ingegerd Gustafsson
    Antibiotic Research Unit, Department of Medical Sciences, Section of Clinical Bacteriology, Uppsala University Hospital, Uppsala, Sweden
    J Antimicrob Chemother 52:645-50. 2003
    ..pharynx (alpha-streptococci) and nostril (coagulase-negative staphylococci, CoNS)...
  33. doi request reprint Nitrofurantoin resistance mechanism and fitness cost in Escherichia coli
    Linus Sandegren
    Department of Medical Biochemistry and Microbiology, Uppsala University, S 75123 Uppsala, Sweden
    J Antimicrob Chemother 62:495-503. 2008
    ..We identified mutations conferring nitrofurantoin resistance and examined their effect on the fitness of clinical Escherichia coli isolates...
  34. pmc Pharmacodynamic model to describe the concentration-dependent selection of cefotaxime-resistant Escherichia coli
    Sara K Olofsson
    Antibiotic Research Unit, Department of Medical Sciences, Clinical Bacteriology and Infectious Diseases, Uppsala University, Sweden
    Antimicrob Agents Chemother 49:5081-91. 2005
    ....
  35. doi request reprint Mutational robustness of ribosomal protein genes
    Peter A Lind
    Department of Medical Biochemistry and Microbiology, Uppsala University, SE 75123 Uppsala, Sweden
    Science 330:825-7. 2010
    ..The DFEs for synonymous and nonsynonymous substitutions are similar, suggesting that in some genes, strong fitness constraints are present at the level of the messenger RNA...
  36. ncbi request reprint Fitness of antibiotic resistant Staphylococcus epidermidis assessed by competition on the skin of human volunteers
    Ingegerd Gustafsson
    Department of Medical Sciences, Clinical Bacteriology, Box 552, Uppsala University, S 751 22 Uppsala, Sweden
    J Antimicrob Chemother 52:258-63. 2003
    ..However, there are limited experimental data on the relative fitness of resistant and susceptible bacteria during growth in their natural environment...
  37. pmc Whole-genome mutational biases in bacteria
    Peter A Lind
    Department of Medical Biochemistry and Microbiology, Uppsala University, S 75123 Uppsala, Sweden
    Proc Natl Acad Sci U S A 105:17878-83. 2008
    ....
  38. ncbi request reprint Predicting antibiotic resistance
    Jose L Martinez
    Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública and Unidad Asociada al CSIC Resistencia a los Antibióticos y Virulencia Bacteriana, Cantoblanco, 28049 Madrid, Spain
    Nat Rev Microbiol 5:958-65. 2007
    ..To this end, we propose the establishment of methodological guidelines that will allow researchers to predict the emergence of resistance to a new antibiotic before its clinical introduction...
  39. pmc Biological costs and mechanisms of fosfomycin resistance in Escherichia coli
    Annika I Nilsson
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, S 171 82 Stockholm, Sweden
    Antimicrob Agents Chemother 47:2850-8. 2003
    ..According to the mathematical model, the reduced growth rate of the resistant strains will prevent them from establishing in the bladder, which could explain why fosfomycin resistance remains rare in clinical isolates...
  40. ncbi request reprint Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolution
    Sophie Maisnier-Patin
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, 171 82 Solna, Sweden
    Res Microbiol 155:360-9. 2004
    ....
  41. pmc Rebuttal: adaptive point mutation (Rosenberg and Hastings)
    John R Roth
    University of California Davis, Microbiology Section, One Shields Ave, Davis, CA 95616, USA
    J Bacteriol 186:4844. 2004
  42. pmc Rebuttal: adaptive mutation in Escherichia coli (Foster)
    John R Roth
    University of California, Davis, Microbiology Section, One Shields Ave, Davis, CA 95616, USA
    J Bacteriol 186:4854. 2004
  43. pmc Adaptive mutation: how growth under selection stimulates Lac(+) reversion by increasing target copy number
    John R Roth
    University of California Davis, Microbiology Section, One Shields Ave, Davis, CA 95616, USA
    J Bacteriol 186:4855-60. 2004
  44. ncbi request reprint Persistence of antibiotic resistant bacteria
    Dan I Andersson
    Swedish Institute for Infectious Disease Control, Dept of Bacteriology, Nobels Väg 18, S 171 82, Stockholm, Sweden
    Curr Opin Microbiol 6:452-6. 2003
    ..Thus, it is of importance that we forcefully implement strategies to reduce the rate of appearance and spread of resistant bacteria to allow new drug discovery to catch up with bacterial resistance development...
  45. pmc Polymorphic mutation frequencies in Escherichia coli: emergence of weak mutators in clinical isolates
    Maria Rosario Baquero
    Servicio de Microbiologia, Hospital Ramon y Cajal, Madrid, Spain
    J Bacteriol 186:5538-42. 2004
    ..7% were strongly hypermutable (f > or = 4 x 10(-7)). Weak mutators were apparently more frequent in southern Europe and in blood isolates (38%) than in urinary tract isolates (25%) and feces of healthy volunteers (11%)...
  46. ncbi request reprint Comparative proteome analysis of Mycobacterium tuberculosis grown under aerobic and anaerobic conditions
    Joakim Starck
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, S 17182, Solna, Sweden
    Microbiology 150:3821-9. 2004
    ..Some protein spots were found to be proteolytic fragments, e.g. HspX and GroEL2. These data suggest that M. tuberculosis induces expression of about 1 % of its genes in response to dormancy...
  47. pmc Experimental adaptation of Salmonella typhimurium to mice
    Annika I Nilsson
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, S 171 82 Solna, Sweden
    Genetics 168:1119-30. 2004
    ..These data show that S. typhimurium can rapidly and extensively increase its fitness in mice but this niche specialization is, at least in mutators, associated with a cost...
  48. ncbi request reprint Genomic buffering mitigates the effects of deleterious mutations in bacteria
    Sophie Maisnier-Patin
    Department of Bacteriology, Swedish Institute for Infectious Disease Control and Microbiology and Tumor Center, Karolinska Institute, S 171 82 Stockholm, Sweden
    Nat Genet 37:1376-9. 2005
    ..These findings suggest that overexpression of chaperones contributes to antagonistic epistasis...
  49. pmc Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes
    Annika I Nilsson
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, S 171 82 Solna, Sweden
    Proc Natl Acad Sci U S A 103:6976-81. 2006
    ..Amplified units varied in size from 1.9 to 94 kbp. Suppression of deleterious mutations by gene amplification may be involved in the evolution of new gene functions...
  50. ncbi request reprint Multiple mechanisms to ameliorate the fitness burden of mupirocin resistance in Salmonella typhimurium
    Wilhelm Paulander
    Department of Bacteriology, Swedish Institute for Infectious Disease Control and Microbiology, Tumor and Cell Biology Center, Karolinska Institute, S 171 82 Solna, Sweden
    Mol Microbiol 64:1038-48. 2007
    ..Our findings show that the fitness costs of ileS mutations conferring mupirocin resistance can be reduced by several types of mechanisms that may contribute to the stability of mupirocin resistance in clinical settings...
  51. ncbi request reprint Origin of mutations under selection: the adaptive mutation controversy
    John R Roth
    Microbiology Section, Division of Biological Sciences, University of California, Davis, California 95616, USA
    Annu Rev Microbiol 60:477-501. 2006
    ..We suggest that the adaptive mutation controversy has persisted because the distinction between these two uses of selection has not been appreciated...
  52. doi request reprint Restored fitness leads to long-term persistence of resistant Bacteroides strains in the human intestine
    Sonja Lofmark
    Department of Laboratory Medicine, Division of Clinical Microbiology, F82, Karolinska University Hospital, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Anaerobe 14:157-60. 2008
    ..The results indicate that the biological cost associated with a resistance gene can rapidly be compensated during in vivo growth. Thus, once the resistant clone has gained its resistance determinant it will be difficult to eliminate...
  53. ncbi request reprint Compensatory adaptation to the deleterious effect of antibiotic resistance in Salmonella typhimurium
    Sophie Maisnier-Patin
    Department of Bacteriology, Swedish Insitute for Infectious Disease Control, Solna, Sweden
    Mol Microbiol 46:355-66. 2002
    ..Our results show that the deleterious effects of a resistance mutation can be compensated by an unexpected variety of mutations...