Irina Alafuzoff

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. doi request reprint Staging/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
    Acta Neuropathol 117:635-52. 2009
  2. pmc Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
    Brain Pathol 18:484-96. 2008
  3. doi request reprint Inter-laboratory comparison of neuropathological assessments of beta-amyloid protein: a study of the BrainNet Europe consortium
    Irina Alafuzoff
    Department of Clinical Medicine, Unit of Neurology, Kuopio University, PO Box 1627, 70 211 Kuopio, Finland
    Acta Neuropathol 115:533-46. 2008
  4. doi request reprint Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus
    Anne M Koivisto
    Unit of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Neurosurgery 72:1-8;discussion 8. 2013
  5. doi request reprint Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalus
    Ville Leinonen
    Department of Neurosurgery, Neurocenter, Kuopio University Hospital, Kuopio, Finland
    Neurodegener Dis 10:166-9. 2012
  6. doi request reprint Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain
    Tero Tapiola
    Department of Neuroscience and Neurology, Clinical Research Center Mediteknia, Kuopio University Hospital, University of Kuopio, Finland
    Arch Neurol 66:382-9. 2009
  7. pmc Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Clinical Medicine, Kuopio University, Finland
    Acta Neuropathol 117:309-20. 2009
  8. doi request reprint Assessment of alpha-synuclein pathology: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
    J Neuropathol Exp Neurol 67:125-43. 2008
  9. doi request reprint Hyperphosphorylated tau in the occipital cortex in aged nondemented subjects
    Maria Pikkarainen
    From the Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University, Kuopio, Finland
    J Neuropathol Exp Neurol 68:653-60. 2009
  10. doi request reprint Heavy alcohol consumption and neuropathological lesions: a post-mortem human study
    Leena Aho
    Department of Clinical Medicine, Unit of Neurology, Kuopio University, Kuopio, Finland
    J Neurosci Res 87:2786-92. 2009

Collaborators

Detail Information

Publications25

  1. doi request reprint Staging/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
    Acta Neuropathol 117:635-52. 2009
    ....
  2. pmc Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
    Brain Pathol 18:484-96. 2008
    ..Thus, in a research setting when the extent of lesions is mild, it is strongly recommended that the assessment of lesions should be carried out by at least two independent observers...
  3. doi request reprint Inter-laboratory comparison of neuropathological assessments of beta-amyloid protein: a study of the BrainNet Europe consortium
    Irina Alafuzoff
    Department of Clinical Medicine, Unit of Neurology, Kuopio University, PO Box 1627, 70 211 Kuopio, Finland
    Acta Neuropathol 115:533-46. 2008
    ....
  4. doi request reprint Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus
    Anne M Koivisto
    Unit of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Neurosurgery 72:1-8;discussion 8. 2013
    ..Idiopathic normal pressure hydrocephalus (iNPH) causes cognitive decline that can be alleviated by shunting, but long-term outcome studies are scarce...
  5. doi request reprint Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalus
    Ville Leinonen
    Department of Neurosurgery, Neurocenter, Kuopio University Hospital, Kuopio, Finland
    Neurodegener Dis 10:166-9. 2012
    ..Brain biopsy did not predict survival but may open a novel research window to study the pathobiology of neurodegeneration...
  6. doi request reprint Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain
    Tero Tapiola
    Department of Neuroscience and Neurology, Clinical Research Center Mediteknia, Kuopio University Hospital, University of Kuopio, Finland
    Arch Neurol 66:382-9. 2009
    ....
  7. pmc Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Clinical Medicine, Kuopio University, Finland
    Acta Neuropathol 117:309-20. 2009
    ..Because most of these blocks are currently routinely sampled by the majority of laboratories, assessment of the A-beta phase in AD is feasible even in large scale retrospective studies...
  8. doi request reprint Assessment of alpha-synuclein pathology: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland
    J Neuropathol Exp Neurol 67:125-43. 2008
    ..Moreover, the study demonstrates that there are limitations in the scoring of alphaS-IR structures...
  9. doi request reprint Hyperphosphorylated tau in the occipital cortex in aged nondemented subjects
    Maria Pikkarainen
    From the Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University, Kuopio, Finland
    J Neuropathol Exp Neurol 68:653-60. 2009
    ..Further systematic clinicopathologic studies are needed for an understanding of regional susceptibility to neurodegeneration and the significance of scattered HPtau-IR brain lesions...
  10. doi request reprint Heavy alcohol consumption and neuropathological lesions: a post-mortem human study
    Leena Aho
    Department of Clinical Medicine, Unit of Neurology, Kuopio University, Kuopio, Finland
    J Neurosci Res 87:2786-92. 2009
    ..Our results indicate that alcohol-related dementia differs from VCI, AD, and DLB; i.e., it has a different etiology and pathogenesis...
  11. doi request reprint The effect of prolonged fixation time on immunohistochemical staining of common neurodegenerative disease markers
    Maria Pikkarainen
    Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University, Kuopio, Finland
    J Neuropathol Exp Neurol 69:40-52. 2010
    ..alpha-Synuclein-immunoreactive structures were visualized up to 14 years but only by the use of Syn42-Ab after formic acid AR or after a combination of heat and formic acid methods...
  12. doi request reprint Systematic appraisal using immunohistochemistry of brain pathology in aged and demented subjects
    Leena Aho
    Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University, Kuopio, Finland
    Dement Geriatr Cogn Disord 25:423-32. 2008
    ..Abnormal processing of hyperphosphorylated tau (HPtau), amyloid-beta (Abeta) and alpha-synuclein (alphaS) proteins is considered as causative with regard to the clinical symptoms in age-related neurodegenerative diseases...
  13. doi request reprint Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brain
    Leena Aho
    Department of Clinical Medicine, Unit of Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 20:1015-28. 2010
    ..The staining results and conclusions depended strongly on the chosen antibody and the pretreatment strategy and thus multiple antibodies must be used when assessing the intracellular accumulation of Abeta...
  14. doi request reprint Distribution and pattern of pathology in subjects with familial or sporadic late-onset cerebellar ataxia as assessed by p62/sequestosome immunohistochemistry
    Maria Pikkarainen
    Department of Clinical Medicine, Unit of Neurology, University of Eastern Finland, Kuopio, Finland
    Cerebellum 10:720-31. 2011
    ..Based on a literature search, it is apparent that there is a need for clinico-pathologic-genetical studies of LOCA, especially to obtain a deeper understanding of the regional distribution and progression of pathology...
  15. doi request reprint TAR-DNA binding protein-43 and alterations in the hippocampus
    Tuomas Rauramaa
    Department of Pathology, Kuopio University Hospital, Kuopio, Finland
    J Neural Transm 118:683-9. 2011
    ..Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain...
  16. doi request reprint Amyloid and tau proteins in cortical brain biopsy and Alzheimer's disease
    Ville Leinonen
    Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland
    Ann Neurol 68:446-53. 2010
    ..Amyloid-β(Aβ) aggregates are presumed to be found in the brain at an early stage of Alzheimer's disease (AD) but have seldom been assessed by brain biopsy during life in often elderly patients...
  17. ncbi request reprint Interlaboratory comparison of assessments of Alzheimer disease-related lesions: a study of the BrainNet Europe Consortium
    Irina Alafuzoff
    Department of Neuroscience and Neurology, Kuopio University, Kuopio University Hospital, Finland
    J Neuropathol Exp Neurol 65:740-57. 2006
    ..Therefore, the IHC/HPtau methodology to visualize NFTs and neuropil threads should be considered as a method of choice in a future diagnostic protocol for Alzheimer disease...
  18. doi request reprint Elucidation of the BACE1 Regulating Factor GGA3 in Alzheimer's Disease
    Teemu Natunen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 37:217-32. 2013
    ..While the present study indicates that GGA3 is involved in the cellular processes relevant for AD pathogenesis, the genetic data do not support the idea that common GGA3 polymorphisms would contribute to AD risk. ..
  19. ncbi request reprint Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients
    Johanna Ojala
    Department of Neuroscience and Neurology, University of Kuopio, Canthia, P O Box 1627, FIN 70211 Kuopio, Finland
    Neurobiol Aging 30:198-209. 2009
    ..Plasma levels of IL-18 showed no correlation with the disease. In conclusion, amyloid-beta may induce the synthesis of IL-18, and IL-18 kinases involved in tau phosphorylation as a part of the amyloid-associated inflammatory reaction...
  20. doi request reprint GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients
    Anna Kämäläinen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 33:23-7. 2013
    ..Our findings suggest that the A allele of rs5848 is functionally relevant by reducing the expression of granulin...
  21. doi request reprint Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions visualized with ubiquitin-binding protein p62 immunohistochemistry
    Maria Pikkarainen
    Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University Hospital, Kuopio, Finland
    J Neuropathol Exp Neurol 67:280-98. 2008
    ....
  22. pmc Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance
    Laura Parkkinen
    Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University, Yliopistonranta 1 C, P O Box 1627, 70211, Kuopio, Finland
    Acta Neuropathol 115:399-407. 2008
    ..However, finding that around half of the subjects with abundant alphaS pathology remain neurologically intact is intriguing and raises the question whether we do assess the actual disease process...
  23. doi request reprint Long-term epilepsy surgery outcomes in patients with MRI-negative temporal lobe epilepsy
    Arto Immonen
    Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland
    Epilepsia 51:2260-9. 2010
    ..The purpose of this study was to determine the long-term outcomes of consecutive true MRI-negative TLE patients who all underwent standardized preoperative evaluation with intracranial electroencephalography (EEG) electrodes...
  24. ncbi request reprint Beta-amyloid aggregation in human brains with cerebrovascular lesions
    Leena Aho
    Department of Clinical Medicine, Neurology, Kuopio University, P O B 1647, Harjulantie 1, Kuopio, Finland
    Stroke 37:2940-5. 2006
    ....
  25. ncbi request reprint Human postmortem brain tissue and 2-mm tissue microarrays
    Tarja Kauppinen
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    Appl Immunohistochem Mol Morphol 14:353-9. 2006
    ..Thus, the applications of this brain TMA block in neurologic research by scientists with different skill bases remain to be determined...