Per Venge

Summary

Affiliation: University Hospital
Country: Sweden

Publications

  1. ncbi Clinical performance of three cardiac troponin assays in patients with unstable coronary artery disease (a FRISC II substudy)
    Per Venge
    Department of Clinical Chemistry, University of Uppsala, Uppsala, Sweden
    Am J Cardiol 89:1035-41. 2002
  2. ncbi Mechanisms of basal and cytokine-induced uptake of glucose in normal human eosinophils: relation to apoptosis
    Per Venge
    Department of Medical Sciences, Clinical Chemistry, University of Uppsala, Uppsala, Sweden
    Respir Med 97:1109-19. 2003
  3. doi Improving long-term risk prediction in patients with acute chest pain: the Global Registry of Acute Coronary Events (GRACE) risk score is enhanced by selected nonnecrosis biomarkers
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
    Am Heart J 160:88-94. 2010
  4. ncbi N-terminal pro-brain natriuretic peptide in relation to inflammation, myocardial necrosis, and the effect of an invasive strategy in unstable coronary artery disease
    Tomas Jernberg
    Department of Medical Sciences, Cardiology, Cardiothoracic Center, University Hospital, Uppsala, Sweden
    J Am Coll Cardiol 42:1909-16. 2003
  5. ncbi Troponin-T and N-terminal pro-B-type natriuretic peptide predict mortality benefit from coronary revascularization in acute coronary syndromes: a GUSTO-IV substudy
    Stefan K James
    Uppsala Clinical Research Center, Uppsala, Sweden
    J Am Coll Cardiol 48:1146-54. 2006
  6. ncbi Serial analyses of N-terminal pro-B-type natriuretic peptide in patients with non-ST-segment elevation acute coronary syndromes: a Fragmin and fast Revascularisation during In Stability in Coronary artery disease (FRISC)-II substudy
    Bertil Lindahl
    Department of Medical Sciences and Cardiology, Uppsala Clinical Research Center, University Hospital, Uppsala, Sweden
    J Am Coll Cardiol 45:533-41. 2005
  7. ncbi A rapid troponin I assay is not optimal for determination of troponin status and prediction of subsequent cardiac events at suspicion of unstable coronary syndromes
    Stefan K James
    Department of Medical Sciences, Cardiology, Uppsala, Sweden
    Int J Cardiol 93:113-20. 2004
  8. doi Pathophysiologic mechanisms of persistent cardiac troponin I elevation in stabilized patients after an episode of acute coronary syndrome
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital, Uppsala, Sweden
    Am Heart J 156:588-94. 2008
  9. ncbi N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease: a Global Utilization of Strategies To Open occluded arteries (
    Stefan K James
    Department of Medical Sciences, Cardiology, University of Uppsala, Uppsala, Sweden
    Circulation 108:275-81. 2003
  10. doi Seemingly healthy 71-year-old men with minor elevations of cardiac troponin I and at risk of premature death in CVD have elevated levels of NT-proBNP: report from the ULSAM study
    Per Venge
    Department of Medical Sciences, University of Uppsala, Uppsala, Sweden
    Scand J Clin Lab Invest 69:418-24. 2009

Detail Information

Publications94

  1. ncbi Clinical performance of three cardiac troponin assays in patients with unstable coronary artery disease (a FRISC II substudy)
    Per Venge
    Department of Clinical Chemistry, University of Uppsala, Uppsala, Sweden
    Am J Cardiol 89:1035-41. 2002
    ..It is also apparent that assays with superior sensitivity, such as the Access AccuTnI, identify more patients with poor prognosis who are candidates for early invasive procedures...
  2. ncbi Mechanisms of basal and cytokine-induced uptake of glucose in normal human eosinophils: relation to apoptosis
    Per Venge
    Department of Medical Sciences, Clinical Chemistry, University of Uppsala, Uppsala, Sweden
    Respir Med 97:1109-19. 2003
    ..Our results suggest a close link between apoptosis and glucose transport in human eosinophils...
  3. doi Improving long-term risk prediction in patients with acute chest pain: the Global Registry of Acute Coronary Events (GRACE) risk score is enhanced by selected nonnecrosis biomarkers
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
    Am Heart J 160:88-94. 2010
    ..However, there is limited knowledge regarding the utility of this score for long-term risk prediction in unselected patients with acute chest pain and whether it might be improved by the integration of nonnecrosis biomarkers...
  4. ncbi N-terminal pro-brain natriuretic peptide in relation to inflammation, myocardial necrosis, and the effect of an invasive strategy in unstable coronary artery disease
    Tomas Jernberg
    Department of Medical Sciences, Cardiology, Cardiothoracic Center, University Hospital, Uppsala, Sweden
    J Am Coll Cardiol 42:1909-16. 2003
    ....
  5. ncbi Troponin-T and N-terminal pro-B-type natriuretic peptide predict mortality benefit from coronary revascularization in acute coronary syndromes: a GUSTO-IV substudy
    Stefan K James
    Uppsala Clinical Research Center, Uppsala, Sweden
    J Am Coll Cardiol 48:1146-54. 2006
    ..This study was designed to evaluate biomarkers for selection of patients with non-ST-segment elevation acute coronary syndromes (ACS) that derive mortality benefit from revascularization...
  6. ncbi Serial analyses of N-terminal pro-B-type natriuretic peptide in patients with non-ST-segment elevation acute coronary syndromes: a Fragmin and fast Revascularisation during In Stability in Coronary artery disease (FRISC)-II substudy
    Bertil Lindahl
    Department of Medical Sciences and Cardiology, Uppsala Clinical Research Center, University Hospital, Uppsala, Sweden
    J Am Coll Cardiol 45:533-41. 2005
    ....
  7. ncbi A rapid troponin I assay is not optimal for determination of troponin status and prediction of subsequent cardiac events at suspicion of unstable coronary syndromes
    Stefan K James
    Department of Medical Sciences, Cardiology, Uppsala, Sweden
    Int J Cardiol 93:113-20. 2004
    ..Troponin is a specific marker of myocardial damage. For early prediction of coronary events in patients with suspicion of acute coronary syndromes the assay also needs to be highly sensitive...
  8. doi Pathophysiologic mechanisms of persistent cardiac troponin I elevation in stabilized patients after an episode of acute coronary syndrome
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital, Uppsala, Sweden
    Am Heart J 156:588-94. 2008
    ..We now have studied the associations of persistently elevated cTnI levels to cardiac performance, inflammation, coagulation, coronary status, and treatment strategy in these patients...
  9. ncbi N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease: a Global Utilization of Strategies To Open occluded arteries (
    Stefan K James
    Department of Medical Sciences, Cardiology, University of Uppsala, Uppsala, Sweden
    Circulation 108:275-81. 2003
    ....
  10. doi Seemingly healthy 71-year-old men with minor elevations of cardiac troponin I and at risk of premature death in CVD have elevated levels of NT-proBNP: report from the ULSAM study
    Per Venge
    Department of Medical Sciences, University of Uppsala, Uppsala, Sweden
    Scand J Clin Lab Invest 69:418-24. 2009
    ..Previous findings identifying a group of seemingly healthy elderly men with very minor elevations of cTnI have shown that these men were at risk of premature cardiovascular death...
  11. doi Tissue localization and the establishment of a sensitive immunoassay of the newly discovered human phospholipase B-precursor (PLB-P)
    Shengyuan Xu
    Dept of Medical Sciences, Clinical Chemistry, Uppsala University, SE 751 85, Uppsala, Sweden
    J Immunol Methods 353:71-7. 2010
    ..The levels correlated to markers of neutrophil activation, suggesting a neutrophil origin of PLB-P in these conditions. The antibodies and the assay will be useful in the future basic and clinical investigations of PLB-P...
  12. doi Growth-differentiation factor-15 is an independent marker of cardiovascular dysfunction and disease in the elderly: results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) Study
    Lars Lind
    Department of Medicine Cardiology and Clinical Chemistry, University of Uppsala, 75185 Uppsala, Sweden
    Eur Heart J 30:2346-53. 2009
    ..Little is known about the pathophysiological basis for the close association of GDF-15 to future CV events. We hypothesized that GDF-15 is related to underlying CV pathologies...
  13. pmc Associations of ECP (eosinophil cationic protein)-gene polymorphisms to allergy, asthma, smoke habits and lung function in two Estonian and Swedish sub cohorts of the ECRHS II study
    Ulla Britt Jönsson
    Department of Medical Sciences, Clinical Chemistry, University of Uppsala, Uppsala, Sweden
    BMC Pulm Med 10:36. 2010
    ..The aim was to study the relationship of these ECP gene polymorphisms to signs and symptoms of allergy and asthma in a community based cohort (The European Community Respiratory Health Survey (ECRHS))...
  14. doi Cardiac troponin-I and risk of heart failure: a community-based cohort study
    Johan Sundstrom
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Eur Heart J 30:773-81. 2009
    ..We examined if circulating levels of cardiac troponin-I (cTnI) predict subsequent heart failure in the community...
  15. ncbi NT-proBNP in unstable coronary artery disease--experiences from the FAST, GUSTO IV and FRISC II trials
    Tomas Jernberg
    Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, University Hospital, Uppsala 751 85, Sweden
    Eur J Heart Fail 6:319-25. 2004
    ..e. unstable angina or non-ST-elevation myocardial infarction. This article focuses on the emerging role of N-terminal pro brain natriuretic peptide (NT-proBNP) and the results from the FAST, GUSTO IV and FRISC II trials...
  16. ncbi Troponin T levels and risk of 30-day outcomes in patients with the acute coronary syndrome: prospective verification in the GUSTO-IV trial
    Stefan James
    Department of Cardiology, Uppsala University Hospital, Uppsala, Sweden
    Am J Med 115:178-84. 2003
    ..However, the appropriate cutoff for identifying patients with the acute coronary syndrome who are at low risk of subsequent mortality has not been established...
  17. doi Cardiac troponin I levels measured with a high-sensitive assay increase over time and are strong predictors of mortality in an elderly population
    Kai M Eggers
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Am Coll Cardiol 61:1906-13. 2013
    ..This study sought to assess changes in troponin levels, underlying conditions, and the prognostic implications in elderly subjects from the community...
  18. doi Clinical performance of two highly sensitive cardiac troponin I assays
    Per Venge
    Department of Medical Sciences, Clinical Chemistry, University of Uppsala
    Clin Chem 55:109-16. 2009
    ..The aim of this study was to compare the clinical performance of 2 sensitive cTnI assays with 10% CV imprecision below the 99th percentile upper reference limit...
  19. doi Prognostic value of biomarkers during and after non-ST-segment elevation acute coronary syndrome
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Centre, Uppsala, Sweden
    J Am Coll Cardiol 54:357-64. 2009
    ..The aim of this study was to assess risk prediction by different biomarkers in patients with an ongoing non-ST-segment elevation acute coronary syndrome (NSTE-ACS) and after clinical stabilization...
  20. ncbi Biochemical indicators of cardiac and renal function in a healthy elderly population
    Nina Johnston
    Department of Medical Sciences, Cardiology, University Hospital, Uppsala, Sweden
    Clin Biochem 37:210-6. 2004
    ..To examine the distributions of NT-proBNP and cystatin C and their relation to age, gender, and other physiological factors in an apparently healthy elderly population...
  21. doi Use of multiple biomarkers to improve the prediction of death from cardiovascular causes
    Bjorn Zethelius
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    N Engl J Med 358:2107-16. 2008
    ..The incremental usefulness of adding multiple biomarkers from different disease pathways for predicting the risk of death from cardiovascular causes has not, to our knowledge, been evaluated among the elderly...
  22. ncbi Risk prediction in chest pain patients by biochemical markers including estimates of renal function
    Kai M Eggers
    Department of Medical Sciences, Cardiology, University Hospital Uppsala, S 751 85 Uppsala, Sweden
    Int J Cardiol 128:207-13. 2008
    ..Early risk stratification of patients with chest pain may be improved by combining cardiac Troponin I (cTnI) results and ECG findings with markers of left-ventricular dysfunction, inflammation or renal function...
  23. ncbi Cell surface expression of FcgammaRI (CD64) on neutrophils and monocytes in patients with influenza A, with and without complications
    Gustav Fjaertoft
    Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden
    Scand J Infect Dis 37:882-9. 2005
    ....
  24. doi Urinary neutrophil gelatinase-associated lipocalin (NGAL) is associated with mortality in a community-based cohort of older Swedish men
    Johanna Helmersson-Karlqvist
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Atherosclerosis 227:408-13. 2013
    ....
  25. ncbi Natriuretic peptides in unstable coronary artery disease
    Tomas Jernberg
    Department of Medical Sciences, Cardiology and Uppsala Research Center, Sweden
    Eur Heart J 25:1486-93. 2004
    ..Before a routine use of BNP or NT-proBNP in unstable CAD can be recommended, the cost-effectiveness of adding these new markers to the currently routine markers and their impact on selection of treatment needs further evaluation...
  26. doi Myeloperoxidase is not useful for the early assessment of patients with chest pain
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
    Clin Biochem 43:240-5. 2010
    ..Myeloperoxidase (MPO) has been listed as a potentially useful risk marker in acute coronary syndrome. However, its clinical utility in patients with acute chest pain is not yet defined...
  27. doi Prevalence and pathophysiological mechanisms of elevated cardiac troponin I levels in a population-based sample of elderly subjects
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Eur Heart J 29:2252-8. 2008
    ....
  28. doi Value of cardiac troponin I cutoff concentrations below the 99th percentile for clinical decision-making
    Kai M Eggers
    Department of Medical Sciences, Uppsala University Hospital, Sweden
    Clin Chem 55:85-92. 2009
    ....
  29. doi Predictors of histology, tissue eosinophilia and mast cell infiltration in Hodgkin's lymphoma--a population-based study
    Ingrid Glimelius
    Department of Radiology, Oncology and Radiation Science Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Eur J Haematol 87:208-16. 2011
    ..The aim of this study was to investigate how selected patient characteristics and genetic factors affect HL phenotype, in particular tissue eosinophilia, mast cell counts and HL histological subtype...
  30. doi Prognostic usefulness of the change in N-terminal pro B-type natriuretic peptide levels to predict mortality in a single community cohort aged ≥ 70 years
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden
    Am J Cardiol 111:131-6. 2013
    ....
  31. doi Growth-differentiation factor-15 for long-term risk prediction in patients stabilized after an episode of non-ST-segment-elevation acute coronary syndrome
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
    Circ Cardiovasc Genet 3:88-96. 2010
    ..This study assessed the time course and the long-term prognostic relevance of GDF-15 levels measured repetitively in patients with non-ST-segment-elevation acute coronary syndrome during 6 months after the acute event...
  32. doi Eosinophil cationic protein (ECP) is processed during secretion
    Charlotte Woschnagg
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    J Immunol 183:3949-54. 2009
    ..Secretion of ECP from eosinophils involves protein modification. The molecular masses of released ECP have acquired the masses of the cytotoxic species...
  33. doi Clinical implications of the change of cardiac troponin I levels in patients with acute chest pain - an evaluation with respect to the Universal Definition of Myocardial Infarction
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital, Sweden
    Clin Chim Acta 412:91-7. 2011
    ..We sought to evaluate the clinical implications of the relative change of cardiac troponin I (cTnI) levels with respect to the Universal Definition in patients with acute chest pain...
  34. ncbi Comparison between second and third generation troponin T assay in patients with symptoms suggestive of an acute coronary syndrome but without ST segment elevation
    Tomas Jernberg
    Department of Medical Sciences, Cardiology, University Hospital, Uppsala, Sweden
    Cardiology 100:29-35. 2003
    ..02 microg/l) and thereby an increased risk of future events. We conclude that the improved precision of the 3rd generation assay does have some clinical implications in terms of improved accuracy of triage and improved prognostic value...
  35. ncbi Neutrophil and monocyte receptor expression in uncomplicated and complicated influenza A infection with pneumonia
    Karlis Pauksens
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Scand J Infect Dis 40:326-37. 2008
    ....
  36. ncbi Persistent cardiac troponin I elevation in stabilized patients after an episode of acute coronary syndrome predicts long-term mortality
    Kai M Eggers
    Department of Medical Sciences, Cardiology, University Hospital Uppsala, S 751 85 Uppsala, Sweden
    Circulation 116:1907-14. 2007
    ..However, the prevalence and prognostic importance of persistent troponin elevation in stabilized patients after an episode of non-ST-elevation acute coronary syndrome are unknown and were therefore assessed in this study...
  37. doi B-type natriuretic peptides and their relation to cardiovascular structure and function in a population-based sample of subjects aged 70 years
    Kai M Eggers
    Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala, Sweden
    Am J Cardiol 103:1032-8. 2009
    ....
  38. doi Normal plasma levels of cardiac troponin I measured by the high-sensitivity cardiac troponin I access prototype assay and the impact on the diagnosis of myocardial ischemia
    Per Venge
    Department of Medical Sciences, University of Uppsala, Sweden
    J Am Coll Cardiol 54:1165-72. 2009
    ..This study sought to evaluate the analytical and clinical performance of the novel hypersensitive cardiac troponin I (cTnI) prototype assay from Beckman Coulter (Fullerton, California)...
  39. doi Factors influencing the 99th percentile of cardiac troponin I evaluated in community-dwelling individuals at 70 and 75 years of age
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University, S 751 85 Uppsala, Sweden
    Clin Chem 59:1068-73. 2013
    ..We aimed to investigate the effects of sex, prevalent cardiovascular disease (CVD), and aging on the 99th percentile of cardiac troponin I (cTnI)...
  40. doi Plasma prolylcarboxypeptidase (angiotensinase C) is increased in obesity and diabetes mellitus and related to cardiovascular dysfunction
    Shengyuan Xu
    Section of Clinical Chemistry, Department of Medical Sciences, University of Uppsala, Uppsala, Sweden
    Clin Chem 58:1110-5. 2012
    ..The objectives of this study were to purify PRCP from a native source, establish a sensitive immunoassay for PRCP, and relate plasma PRCP concentrations to signs and symptoms of obesity, diabetes mellitus, and cardiovascular dysfunction...
  41. doi Activity and turnover of eosinophil and neutrophil granulocytes are altered in visceral leishmaniasis
    Amir I Elshafie
    Unit of Clinical Immunology, Uppsala University, Uppsala, Sweden
    Int J Parasitol 41:463-9. 2011
    ..The combined assay of ECP and MPO in serum and plasma provides further insight into the mechanisms of eosinophil and neutrophil involvement in disease and constitutes a novel approach to the study of disease processes...
  42. doi The identification of a phospholipase B precursor in human neutrophils
    Shengyuan Xu
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Sweden
    FEBS J 276:175-86. 2009
    ..The existence of the PLB precursor in neutrophils and its enzymatic activity against phospholipids suggest a role in the defence against invading microorganisms and in the generation of lipid mediators of inflammation...
  43. ncbi The antibody configurations of cardiac troponin I assays may determine their clinical performance
    Stefan James
    Department of Medical Sciences, Cardiology, Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Clin Chem 52:832-7. 2006
    ..The approach has been adopted by the new cTnI assay from Abbott Diagnostics. The aim of our study was to investigate whether this approach affects the clinical performance of cTnI assays...
  44. ncbi An enzyme-linked immunosorbent assay for human carcinoembryonic antigen-related cell adhesion molecule 8, a biological marker of granulocyte activities in vivo
    Linshu Zhao
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, S 751 85, Uppsala, Sweden
    J Immunol Methods 293:207-14. 2004
    ....
  45. pmc Eosinophil associated genes in the inflammatory bowel disease 4 region: correlation to inflammatory bowel disease revealed
    Kristin Blom
    Department of Medical Sciences, Clinical Chemistry, Uppsala University Hospital, SE 75185 Uppsala, Sweden
    World J Gastroenterol 18:6409-19; discussion p. 6417-8. 2012
    ..To study the association between inflammatory bowel disease (IBD) and genetic variations in eosinophil protein X (EPX) and eosinophil cationic protein (ECP)...
  46. doi Will the universal definition of myocardial infarction criteria result in an overdiagnosis of myocardial infarction?
    Kai M Eggers
    Department of Medical Sciences, Uppsala University Hospital, Sweden
    Am J Cardiol 103:588-91. 2009
    ..In conclusion, our results emphasized the importance of a significant change in cardiac troponin to avoid misdiagnosis of AMI...
  47. ncbi Neutrophil CD64 (FcgammaRI) expression is a specific marker of bacterial infection: a study on the kinetics and the impact of major surgery
    Gustav Fjaertoft
    Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden
    Scand J Infect Dis 39:525-35. 2007
    ..Neutrophil expression of CD64, therefore, seems to be a promising tool for the early detection of bacterial infections even during surgery...
  48. doi The new high-sensitivity cardiac troponin T assay improves risk assessment in acute coronary syndromes
    Bertil Lindahl
    Department of Medical Sciences, Cardiology, and Uppsala Clinical Research Center, University of Uppsala, Uppsala, Sweden
    Am Heart J 160:224-9. 2010
    ..However, how the hs-cTnT assay compares with the old cTnT assay for risk assessment in ACS is still unknown...
  49. doi High-sensitive cardiac troponin T outperforms novel diagnostic biomarkers in patients with acute chest pain
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden
    Clin Chim Acta 413:1135-40. 2012
    ..However, the information obtained from hs-cTnT levels might be improved when combined with results of other biomarkers of myocardial injury...
  50. doi Early and late outcome prediction of death in the emergency room setting by point-of-care and laboratory assays of cardiac troponin I
    Per Venge
    Department of Medical Sciences, Clinical Chemistry, University of Uppsala, Uppsala, Sweden
    Am Heart J 160:835-41. 2010
    ..The question raised was as follows: What is the clinical impact of the results of POC assays of cardiac troponins as compared with sensitive laboratory assays?..
  51. doi Effect of eosinophil cationic protein (ECP) on Hodgkin lymphoma cell lines
    Ingrid Glimelius
    Department of Radiology, Oncology and Radiation Sciences, Uppsala University, Uppsala, Sweden
    Exp Hematol 39:850-8. 2011
    ..Our aim was to investigate the effects of eosinophil cationic protein (ECP) on HL tumor cells in vitro...
  52. ncbi Troponin I as a predictor of coronary heart disease and mortality in 70-year-old men: a community-based cohort study
    Bjorn Zethelius
    Department of Public Health and Caring Sciences Geriatrics, University of Uppsala, Uppsala, Sweden
    Circulation 113:1071-8. 2006
    ..Cardiac TnI concentrations increase with age in subjects free from clinical signs of CHD, suggesting silent myocardial damage. We investigated the association between cTnI and future CHD and mortality in a community-based cohort of men...
  53. doi Autoantibodies to cardiac troponin in acute coronary syndromes
    Bertil Lindahl
    Department of Medical Sciences and Uppsala Clinical Research Center, University of Uppsala, Sweden
    Clin Chim Acta 411:1793-8. 2010
    ..However, the prognostic importance of the occurrence of cTnaAb is unknown...
  54. ncbi Selective priming of peripheral blood eosinophils in patients with idiopathic hypereosinophilic syndrome
    Maria Lampinen
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
    APMIS 114:757-63. 2006
    ..Interleukin (IL)-5 has previously been shown to prime eosinophils for migratory responses, and successful anti-IL-5 therapy of patients with HES indicates an important role for this cytokine in the development of hypereosinophilia...
  55. doi The coding ECP 434(G>C) gene polymorphism determines the cytotoxicity of ECP but has minor effects on fibroblast-mediated gel contraction and no effect on RNase activity
    Jenny Rubin
    Department of Medical Sciences, Uppsala University, Sweden
    J Immunol 183:445-51. 2009
    ....
  56. doi Mid-regional pro-atrial natriuretic peptide levels in the elderly: clinical and prognostic implications, and comparison to B-type natriuretic peptides
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden
    Clin Chim Acta 419:62-6. 2013
    ..However, there are only sparse data on its clinical value relative to the B-type natriuretic peptides in the general population...
  57. doi Cardiac troponin assay classification by both clinical and analytical performance characteristics: a study on outcome prediction
    Per Venge
    Department of Medical Sciences, Clinical Chemistry, University of Uppsala, Uppsala, Sweden
    Clin Chem 59:976-81. 2013
    ..We compared four widely used "clinically usable" cardiac troponin I (cTnI) assays with an assay designated "not acceptable" for accuracy in predicting the clinical outcome of death...
  58. ncbi Human neutrophil lipocalin (HNL) as a diagnostic tool in children with acute infections: a study of the kinetics
    Gustav Fjaertoft
    Department of Women s and Children s Health, University of Uppsala, Uppsala, Sweden
    Acta Paediatr 94:661-6. 2005
    ..To study the changes in blood of human neutrophil lipocalin (HNL) and C-reactive protein (CRP) during the course of an acute infection in children...
  59. ncbi A SELDI-TOF MS study of the genetic and post-translational molecular heterogeneity of eosinophil cationic protein
    Jenny Eriksson
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    J Leukoc Biol 82:1491-500. 2007
    ....
  60. ncbi N-terminal pro brain natriuretic peptide on admission for early risk stratification of patients with chest pain and no ST-segment elevation
    Tomas Jernberg
    Department of Medical Sciences, Cardiology, University Hospital, Uppsala, Sweden
    J Am Coll Cardiol 40:437-45. 2002
    ..The study evaluated the prognostic value of single measurement of N-terminal pro brain natriuretic peptide (NT-proBNP) obtained on admission in patients with symptoms suggestive of an acute coronary syndrome and no ST-segment elevation...
  61. ncbi Clinical and analytical performance of the liaison cardiac troponin I assay in unstable coronary artery disease, and the impact of age on the definition of reference limits. A FRISC-II substudy
    Per Venge
    Department of Medical Sciences, University of Uppsala, SE 751 85 Uppsala, Sweden
    Clin Chem 49:880-6. 2003
    ..Our aim was to evaluate the clinical and analytical performance of the Liaison cardiac troponin I (cTnI) assay...
  62. ncbi The prognostic and therapeutic implications of increased troponin T levels and ST depression in unstable coronary artery disease: the FRISC II invasive troponin T electrocardiogram substudy
    Erik Diderholm
    Department of Cardiology, University Hospital, Uppsala, Sweden
    Am Heart J 143:760-7. 2002
    ....
  63. ncbi The 434(G>C) polymorphism within the coding sequence of Eosinophil Cationic Protein (ECP) correlates with the natural course of Schistosoma mansoni infection
    Jenny Eriksson
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala Academic Hospital, SE 75185 Uppsala, Sweden
    Int J Parasitol 37:1359-66. 2007
    ..mansoni and in the development of periportal fibrosis. The results also suggest genetic selection towards the ECP 434CC genotype in populations living in S. mansoni endemic areas...
  64. ncbi Lateral flow immunoassay using Europium (III) chelate microparticles and time-resolved fluorescence for eosinophils and neutrophils in whole blood
    Gerd Rundström
    Department for Surface Biotechnology, Uppsala University, Uppsala, Sweden
    Clin Chem 53:342-8. 2007
    ..We developed a protocol for measuring cell count by disrupting the cell membrane and analyzing specific proteins within the cells and used it to analyze proteins from eosinophils and neutrophils...
  65. doi Relationship between sleep-disordered breathing and markers of systemic inflammation in women from the general population
    Malin Svensson
    Department of Surgical Sciences, Otorhinolaryngology, Head and Neck Surgery, Uppsala University, Uppsala, Sweden
    J Sleep Res 21:147-54. 2012
    ..The results indicate that intermittent hypoxia, and not the AHI, is related to systemic inflammation seen in OSAS...
  66. pmc Uncoordinated production of Laminin-5 chains in airways epithelium of allergic asthmatics
    Kawa Amin
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Respir Res 6:110. 2005
    ..The aim was to characterize the presence of Laminin chains in the SEBM and epithelium in allergic and non-allergic asthmatics...
  67. pmc Purification of a 75 kDa protein from the organelle matrix of human neutrophils and identification as N-acetylglucosamine-6-sulphatase
    Shengyuan Xu
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, SE 751 85, Uppsala, Sweden
    Biochem J 387:841-7. 2005
    ..The presence of N-acetylglucosamine-6-sulphatase in human neutrophils implies that neutrophils may play a role in the modulation of cell surface molecules and extracellular matrix by O-desulphation...
  68. doi C3b-induced eosinophil degranulation involves PI3-kinases and is inhibited by protein kinase C activity
    Marie Carlson
    Department of Medical Sciences, University Hospital, Uppsala University, Sweden
    APMIS 119:119-26. 2011
    ..PI3-kinases play an important role in the C3b-induced release of ECP, EPO and EPX/EDN, whereas protein kinase C seems to have inhibitory effects on C3b-induced degranulation...
  69. doi High-sensitive troponin T and I are related to invasive hemodynamic data and mortality in patients with left-ventricular dysfunction and precapillary pulmonary hypertension
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden
    Clin Chim Acta 412:1582-8. 2011
    ....
  70. doi ST2 and mortality in non-ST-segment elevation acute coronary syndrome
    Kai M Eggers
    Department of Medical Sciences, Uppsala University, Sweden
    Am Heart J 159:788-94. 2010
    ....
  71. doi The human eosinophil proteome. Changes induced by birch pollen allergy
    Charlotte Woschnagg
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, 75185 Uppsala, Sweden
    J Proteome Res 8:2720-32. 2009
    ..The link between these findings and an increased cellular antigen-presenting capacity and motility are discussed...
  72. ncbi Evaluation of laboratory markers for the detection of infections in open-heart surgery patients
    Anders Lannergård
    Department of Medical Sciences, Sections of Infectious Diseases and Clinical Chemistry, Uppsala University Hospital, Uppsala, Sweden
    Scand J Infect Dis 35:121-6. 2003
    ..HNL and WBC counts were ineffectual as indicators of postoperative infections in this study...
  73. ncbi Troponin and C-reactive protein have different relations to subsequent mortality and myocardial infarction after acute coronary syndrome: a GUSTO-IV substudy
    Stefan K James
    Department of Medical Sciences Cardiology, Thoraxcenter, Academic Hospital, 751 85 Uppsala, Sweden
    J Am Coll Cardiol 41:916-24. 2003
    ..We sought to evaluate C-reactive protein (CRP) and troponin T (TnT) as predictors of risk of the individual end points of mortality and myocardial infarction (MI) in a large cohort of patients with acute coronary syndrome (ACS)...
  74. ncbi Albumin stimulation of eosinophil migration involves PI3-kinases and is associated with diminished eosinophil CD49d and CD49f expression
    Maria Lampinen
    Asthma Research Centre, University Hospital, Uppsala, Sweden
    Int Arch Allergy Immunol 140:113-20. 2006
    ..We have previously found that IL-2 inhibits albumin-stimulated eosinophil migration. The aim of this study was to identify the mechanisms behind the effects of albumin and IL-2 on the migration of human eosinophils...
  75. ncbi The impact of atopy on neutrophil activity in middle ear effusion from children and adults with chronic otitis media
    David S Hurst
    Department of Medical Sciences, Laboratory for Inflammation Research, University Hospital, Uppsala University, Sweden
    Arch Otolaryngol Head Neck Surg 128:561-6. 2002
    ..To identify the relationship of neutrophil activity to allergy as reflected by the level of myeloperoxidase (MPO) in ears of atopic patients with chronic otitis media with effusion (OME) by objective testing...
  76. ncbi Apoptotic eosinophils express IL-2R chains alpha and beta and co-stimulatory molecules CD28 and CD86
    Kristina Seton
    Department of Medical Sciences, Unit of Clinical Chemistry, University Hospital, Uppsala University, Uppsala 5 751 85, Sweden
    Respir Med 97:893-902. 2003
    ..In addition, the co-stimulatory molecules CD28, CD86 and CD40 are associated to lymphocytes and antigen processing. Under certain conditions, eosinophils are also able to express these antigens on their surface...
  77. doi Gluten sensitivity in patients with IgA nephropathy
    Hilde Kloster Smerud
    Section of Nephrology, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Nephrol Dial Transplant 24:2476-81. 2009
    ..Coeliac disease is more frequent in IgA nephropathy (IgAN) patients compared to the healthy population. Several hypotheses postulate that food antigens like gluten may be involved in the onset of IgAN...
  78. ncbi A (G->C) transversion in the 3' UTR of the human ECP (eosinophil cationic protein) gene correlates to the cellular content of ECP
    Ulla Britt Jönsson
    Department of Medical Sciences, Clinical Chemistry, University Hospital, SE 751 85 Uppsala, Sweden
    J Leukoc Biol 79:846-51. 2006
    ..The 562(G > C) polymorphism in the 3'-end of the UTR of the ECP gene may determine the ECP content in human eosinophils, but unlike the 434(G > C) polymorphism, the 562(G > C) polymorphism is not related to allergy...
  79. ncbi The eosinophil and airway remodelling in asthma
    Per Venge
    Department of Medical Sciences, University of Uppsala, Uppsala, Sweden
    Clin Respir J 4:15-9. 2010
    ..Eosinophils are common findings cells in allergic asthma as is sub-base membrane thickening of the airways. The objective of this review was to summarise some recent findings linking the activities of eosinophils to airways remodelling...
  80. pmc Expression of the C5a receptor (CD88) on granulocytes and monocytes in patients with severe sepsis
    Mia Furebring
    Department of Medical Sciences, Section of Infectious Diseases, University Hospital of Uppsala, Sweden
    Crit Care 6:363-70. 2002
    ....
  81. ncbi Priming of eosinophil migration across lung epithelial cell monolayers and upregulation of CD11b/CD18 are elicited by extracellular Ca2+
    Lixin Liu
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Am J Respir Cell Mol Biol 28:713-21. 2003
    ..We suggest that, as an important priming signal for human eosinophil functional responses, store-operated Ca2+ entry may be one of the underlying mechanisms of eosinophilic inflammation in asthma...
  82. ncbi Multicenter evaluation of an automated assay for troponin I
    Denise Uettwiller-Geiger
    John T Mather Memorial Hospital, Port Jefferson, NY 11777, USA
    Clin Chem 48:869-76. 2002
    ..We describe an assay that overcomes problems of early assays that were often affected by cTnI degradation, assay interference, poor sensitivity, and imprecision...
  83. ncbi Quantitative analysis of the admission electrocardiogram identifies patients with unstable coronary artery disease who benefit the most from early invasive treatment
    Lene Holmvang
    The Heart Center 2141, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    J Am Coll Cardiol 41:905-15. 2003
    ..The present study is a sub-study of the previously published Fast Revascularization during InStability in Coronary artery disease trial (FRISC-II)...
  84. ncbi Human neutrophil lipocalin: a specific marker for neutrophil activation in severe Plasmodium falciparum malaria
    Abdelrahim O Mohammed
    Department of Biochemistry, Faculty of Medicine, University of Khartoum, Box 102 Khartoum, Sudan
    Acta Trop 87:279-85. 2003
    ..These results confirm our previous findings that neutrophils are activated in-patients with severe malaria and the level of HNL is a good marker in this context...
  85. ncbi [BNP or NT-proBNP should be analyzed in suspected heart failure. Guidelines for analysis and interpretation]
    Tomas Jernberg
    Hjartkliniken, Karolinska Universitetssjukhuset, Stockholm
    Lakartidningen 103:1289-92, 1295. 2006
  86. ncbi Kinetics of mucosal granulocyte activation after gluten challenge in coeliac disease
    Gudjon Kristjansson
    Department of Gastroenterology, Hospital General Vall d Hebron, Barcelona, Spain
    Scand J Gastroenterol 40:662-9. 2005
    ..To elucidate the dynamics of the rectal inflammatory response to rectal gluten challenge in coeliac disease by measuring inflammatory mediators released by activated neutrophils, eosinophils and mast cells/basophils...
  87. ncbi NT-ProBNP in non-ST-elevation acute coronary syndrome
    Tomas Jernberg
    Department of Medical Sciences and Cardiology and the Uppsala Clinical Research Center, Sweden
    J Card Fail 11:S54-8. 2005
    ..The role of N-terminal pro-brain natriuretic peptide (NT-proBNP) in the early treatment of patients with non-ST-elevation acute coronary syndrome (NSTACS) has been evaluated in 6 large studies that include >12,000 patients...
  88. ncbi [Prognosis in unstable coronary artery disease. Multimarker strategy is the best basis for the therapeutic choice]
    Stefan James
    Kardiologiska kliniken, Akademiska sjukhuset, Uppsala
    Lakartidningen 101:1514-9, 1521-2. 2004
    ....
  89. ncbi Admission Troponin T and measurement of ST-segment resolution at 60 min improve early risk stratification in ST-elevation myocardial infarction
    Erik Bjorklund
    Department of Cardiology, University Hospital of Uppsala, Sweden
    Eur Heart J 25:113-20. 2004
    ..However, the combination of these two early available markers for predicting risk has not been evaluated...
  90. ncbi Growth differentiation factor 15 for risk stratification and selection of an invasive treatment strategy in non ST-elevation acute coronary syndrome
    Kai C Wollert
    Department of Cardiology and Angiology, Hannover University Medical School, Hannover, Germany
    Circulation 116:1540-8. 2007
    ..We hypothesized that the circulating level of growth differentiation factor 15 (GDF-15) may improve risk stratification...
  91. ncbi Eosinophil cationic protein alters pulmonary surfactant structure and function in asthma
    Jens M Hohlfeld
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    J Allergy Clin Immunol 113:496-502. 2004
    ..Eosinophils are potent effector cells in asthma, which, on activation, release inflammatory mediators, especially reactive granula proteins such as eosinophil cationic protein (ECP)...
  92. ncbi Cystatin C as a marker of immune complex-associated renal impairment in a Sudanese population with visceral leishmaniasis
    Amir Ibrahim ElShafie
    Department of Clinical Pathology and Microbiology, Alribat University Hospital, Khartoum, Sudan
    Am J Trop Med Hyg 75:864-8. 2006
    ....
  93. ncbi Proteomic analysis of human cervical-vaginal fluids
    Li jun Tang
    Leukocyte Biology and Proteomics Groups, International Centre for Genetic Engineering and Biotechnology, Area Science Park, Padriciano 99, 34012 Trieste, Italy
    J Proteome Res 6:2874-83. 2007
    ..Neutrophil and eosinophil granule secretion proteins were also detected in variable amounts in the lavage fluids by both immunoassay and immunoblotting, indicating polymorphonuclear cell activation...
  94. ncbi Eosinophil cationic protein stimulates TGF-beta1 release by human lung fibroblasts in vitro
    Ulrika Zagai
    Division of Respiratory Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Inflammation 30:153-60. 2007
    ..This may be an important mechanism by which ECP promotes remodeling of extra cellular matrix leading to airway fibrosis in asthmatics...