Thomas Sandstrom

Summary

Affiliation: University Hospital
Country: Sweden

Publications

  1. pmc Omalizumab in the management of patients with allergic (IgE-mediated) asthma
    Thomas Sandstrom
    Department of Respiratory Medicine and Allergy, University Hospital, Umea, Sweden
    J Asthma Allergy 2:49-62. 2009
  2. ncbi request reprint Assessment of the capacity of vehicle cabin air inlet filters to reduce diesel exhaust-induced symptoms in human volunteers
    Ala Muala
    Department of Public Health and Clinical Medicine, Division of Medicine, Umea University, Umea, Sweden
    Environ Health 13:16. 2014
  3. pmc Wood smoke particles from different combustion phases induce similar pro-inflammatory effects in a co-culture of monocyte and pneumocyte cell lines
    Anette Kocbach Bølling
    Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
    Part Fibre Toxicol 9:45. 2012
  4. pmc Experimental determination of the respiratory tract deposition of diesel combustion particles in patients with chronic obstructive pulmonary disease
    Jakob Löndahl
    Department of Physics, Division of Nuclear Physics, Lund University, Lund, Sweden
    Part Fibre Toxicol 9:30. 2012
  5. pmc Exposure to diesel exhaust induces changes in EEG in human volunteers
    Bjorn Cruts
    Centre of Expertise in Life Sciences, Zuyd University, Heerlen, The Netherlands
    Part Fibre Toxicol 5:4. 2008
  6. pmc Epithelial expression of mRNA and protein for IL-6, IL-10 and TNF-alpha in endobronchial biopsies in horses with recurrent airway obstruction
    Miia Riihimäki
    Department of Clinical Sciences, Equine Internal Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden
    BMC Vet Res 4:8. 2008
  7. ncbi request reprint [Anti-IgE blocks central asthmatic mechanism]
    Thomas Sandstrom
    Lung och allergikliniken, Norrlands universitetssjuk hus, Umea
    Lakartidningen 105:1933-4. 2008
  8. pmc Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium
    Jamshid Pourazar
    Department of Respiratory Medicine and Allergy, University Hospital, Umea, Sweden
    Part Fibre Toxicol 5:8. 2008
  9. doi request reprint Effects of pharmacological and non-pharmacological interventions
    Thomas Sandstrom
    Department of Public Health and Clinical Medicine, Division of Medicine, Umea University, Umea, Sweden
    Clin Respir J 4:41-8. 2010
  10. doi request reprint Desert dust: an unrecognized source of dangerous air pollution?
    Thomas Sandstrom
    Department of Public Health and Clinical Medicine, Sections of Respiratory Medicine and Occupational Environmental Medicine, Umea University, Sweden
    Epidemiology 19:808-9. 2008

Collaborators

Detail Information

Publications33

  1. pmc Omalizumab in the management of patients with allergic (IgE-mediated) asthma
    Thomas Sandstrom
    Department of Respiratory Medicine and Allergy, University Hospital, Umea, Sweden
    J Asthma Allergy 2:49-62. 2009
    ..Long-term therapy with omalizumab shows the potential for disease-modification in asthma. Ongoing studies are also evaluating the use of omalizumab in other non-asthma IgE-mediated conditions...
  2. ncbi request reprint Assessment of the capacity of vehicle cabin air inlet filters to reduce diesel exhaust-induced symptoms in human volunteers
    Ala Muala
    Department of Public Health and Clinical Medicine, Division of Medicine, Umea University, Umea, Sweden
    Environ Health 13:16. 2014
    ..In this study, we evaluated the ability of novel vehicle cabin air inlet filters to reduce diesel exhaust (DE)-induced symptoms and markers of inflammation in human subjects...
  3. pmc Wood smoke particles from different combustion phases induce similar pro-inflammatory effects in a co-culture of monocyte and pneumocyte cell lines
    Anette Kocbach Bølling
    Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
    Part Fibre Toxicol 9:45. 2012
    ..The overall aim of this study was therefore to investigate cellular responses to wood smoke particles (WSPs) collected from different phases of the combustion cycle, and from combustion at different temperatures...
  4. pmc Experimental determination of the respiratory tract deposition of diesel combustion particles in patients with chronic obstructive pulmonary disease
    Jakob Löndahl
    Department of Physics, Division of Nuclear Physics, Lund University, Lund, Sweden
    Part Fibre Toxicol 9:30. 2012
    ..There are few data on lung deposition of airborne particles in patients with COPD and none for combustion particles...
  5. pmc Exposure to diesel exhaust induces changes in EEG in human volunteers
    Bjorn Cruts
    Centre of Expertise in Life Sciences, Zuyd University, Heerlen, The Netherlands
    Part Fibre Toxicol 5:4. 2008
    ..abstract:..
  6. pmc Epithelial expression of mRNA and protein for IL-6, IL-10 and TNF-alpha in endobronchial biopsies in horses with recurrent airway obstruction
    Miia Riihimäki
    Department of Clinical Sciences, Equine Internal Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden
    BMC Vet Res 4:8. 2008
    ....
  7. ncbi request reprint [Anti-IgE blocks central asthmatic mechanism]
    Thomas Sandstrom
    Lung och allergikliniken, Norrlands universitetssjuk hus, Umea
    Lakartidningen 105:1933-4. 2008
  8. pmc Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium
    Jamshid Pourazar
    Department of Respiratory Medicine and Allergy, University Hospital, Umea, Sweden
    Part Fibre Toxicol 5:8. 2008
    ..abstract:..
  9. doi request reprint Effects of pharmacological and non-pharmacological interventions
    Thomas Sandstrom
    Department of Public Health and Clinical Medicine, Division of Medicine, Umea University, Umea, Sweden
    Clin Respir J 4:41-8. 2010
    ..These processes and the underlying mechanisms have attracted considerable attention...
  10. doi request reprint Desert dust: an unrecognized source of dangerous air pollution?
    Thomas Sandstrom
    Department of Public Health and Clinical Medicine, Sections of Respiratory Medicine and Occupational Environmental Medicine, Umea University, Sweden
    Epidemiology 19:808-9. 2008
    ..This may be of concern for large areas of the globe that periodically encounter high levels of windblown desert dust and warrants further attention...
  11. ncbi request reprint Traffic-related pollution and lung development in children
    Thomas Sandstrom
    Department of Respiratory Medicine and Allergy, University Hospital, Umeå SE 901 85, Sweden
    Lancet 369:535-7. 2007
  12. ncbi request reprint The need for a focus on air pollution research in the elderly
    T Sandstrom
    Dept of Respiratory Medicine and Allergy, University Hospital, Umea, Sweden
    Eur Respir J Suppl 40:92s-95s. 2003
    ..A major focus on the adverse air pollution effects in the elderly requires a long-term commitment that still remains to be established...
  13. ncbi request reprint Targeting immunoglobulin E as a novel treatment for asthma
    Thomas Sandstrom
    Department of Respiratory Medicine and Allergy, University Hospital, SE 901 85 Umea, Sweden
    Curr Allergy Asthma Rep 5:109-15. 2005
    ..Omalizumab is a significant addition to current asthma treatments and shows great promise as a therapy for allergic rhinitis, in particular for those patients with concomitant allergic disease...
  14. ncbi request reprint Recent outcomes in European multicentre projects on ambient particulate air pollution
    Thomas Sandstrom
    Department of Respiratory Medicine and Allergy, University Hospital, SE 901 85 Umea, Sweden
    Toxicol Appl Pharmacol 207:261-8. 2005
    ..Investigations have also given support for the assumption that asthmatic and elderly subjects with chronic obstructive pulmonary disease may be more susceptible to PM exposure...
  15. ncbi request reprint Diesel exhaust activates redox-sensitive transcription factors and kinases in human airways
    Jamshid Pourazar
    Dept of Respiratory Medicine and Allergy, Univ Hospital, SE 901 85 Umea, Sweden
    Am J Physiol Lung Cell Mol Physiol 289:L724-30. 2005
    ..05). These observations demonstrate that DE activates redox-sensitive transcription factors in vivo consistent with oxidative stress triggering the increased synthesis of proinflammatory cytokines...
  16. doi request reprint Suppressed signal transduction in the bronchial epithelium of patients with systemic sclerosis
    Maria Sehlstedt
    Department of Respiratory Medicine and Allergy, University Hospital, 901 85 Umea, Sweden
    Respir Med 103:301-8. 2009
    ..Systemic sclerosis (SSc) is an autoimmune disorder, which frequently affects the lungs, with manifestations of interstitial lung disease (ILD) with lung fibrosis and of pulmonary hypertension. The pathogenesis remains largely unrecognised...
  17. pmc Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions
    Stefan Barath
    Department of Public Health and Clinical Medicine, Umea University, Sweden
    Part Fibre Toxicol 7:19. 2010
    ..Controlled human exposure studies have demonstrated impaired vascular function after inhalation of exhaust generated by a diesel engine under idling conditions...
  18. pmc Short-term exposure to ozone does not impair vascular function or affect heart rate variability in healthy young men
    Stefan Barath
    Department of Public Health and Clinical Medicine, Division of Medicine Respiratory Medicine, Umea University, Umea, Sweden
    Toxicol Sci 135:292-9. 2013
    ....
  19. doi request reprint Early suppression of NFkappaB and IL-8 in bronchial epithelium after ozone exposure in healthy human subjects
    Jenny Bosson
    Department of Respiratory Medicine and Allergy, University Hospital, Umea, Sweden
    Inhal Toxicol 21:913-9. 2009
    ....
  20. doi request reprint Proinflammatory doses of diesel exhaust in healthy subjects fail to elicit equivalent or augmented airway inflammation in subjects with asthma
    Annelie F Behndig
    Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden
    Thorax 66:12-9. 2011
    ..Here the hypothesis that this heightened sensitivity reflects an augmentation of the transient inflammatory response previously reported in healthy adults exposed to diesel exhaust is examined...
  21. doi request reprint Airway inflammatory response to diesel exhaust generated at urban cycle running conditions
    Maria Sehlstedt
    Department of Public Health and Clinical Medicine, Respiratory Medicine, Umea University, Umea, Sweden
    Inhal Toxicol 22:1144-50. 2010
    ....
  22. ncbi request reprint Effect of inhaled fluticasone with and without salmeterol on airway inflammation in asthma
    Annika Wallin
    Department of Respiratory Medicine and Allergy, University Hospital, Umea
    J Allergy Clin Immunol 112:72-8. 2003
    ..However, there are concerns that this might result in a masking of underlying airway inflammation...
  23. ncbi request reprint The nitrogen mustard melphalan activates mitogen-activated phosphorylated kinases (MAPK), nuclear factor-kappaB and inflammatory response in lung epithelial cells
    Camilla Osterlund
    Division of NBC Defence, Swedish Defence Research Agency, Umea, Sweden
    J Appl Toxicol 25:328-37. 2005
    ....
  24. ncbi request reprint Ozone enhances the airway inflammation initiated by diesel exhaust
    Jenny Bosson
    Department of Respiratory Medicine and Allergy, University Hospital, SE 901 85 Umea, Sweden
    Respir Med 101:1140-6. 2007
    ..This interaction between exposure to particulate pollution and O(3) in sequence should be taken into consideration when health effects of air pollution are considered...
  25. pmc Antioxidant airway responses following experimental exposure to wood smoke in man
    Maria Sehlstedt
    Department of Public Health and Clinical Medicine, Division of Medicine, Umea University, Umea, Sweden
    Part Fibre Toxicol 7:21. 2010
    ..Symptoms, lung function, and exhaled NO were measured over exposures, with bronchoscopy performed 24 h post-exposure for characterisation of airway inflammatory and antioxidant responses in airway lavages...
  26. ncbi request reprint Diesel exhaust exposure enhances the expression of IL-13 in the bronchial epithelium of healthy subjects
    Jamshid Pourazar
    Department of Respiratory Medicine and Allergy, University Hospital, Umeå SE 901 85, Sweden
    Respir Med 98:821-5. 2004
    ..1 (1.35-4.88) Md (Q1-Q3) vs. air 0.94 (0.53-1.23); P = 0.009. No significant changes were seen in IL-10 and IL-18 expression. This finding suggests an TH2-inflammatory response in the airways of non-atopic healthy individuals...
  27. ncbi request reprint Persistent endothelial dysfunction in humans after diesel exhaust inhalation
    Håkan Törnqvist
    Department of Respiratory Medicine and Allergy, Umea University Hospital, SE 901 85 Umea, Sweden
    Am J Respir Crit Care Med 176:395-400. 2007
    ..We have previously demonstrated that inhalation of diesel exhaust causes an immediate (within 2 h) impairment of vascular and endothelial function in humans...
  28. doi request reprint Presence of activated airway T lymphocytes in human puumala hantavirus disease
    Johan Rasmuson
    Infectious Diseases, Department of Clinical Microbiology, Umea University, SE 901 85, Umea, Sweden
    Chest 140:715-22. 2011
    ..The clinical spectrum in HFRS also often involves respiratory symptoms. As information about the pulmonary pathogenesis in HFRS is limited, we aimed to further study the local airway immune response in the lower airways...
  29. ncbi request reprint Bronchoalveolar matrix metalloproteinase 9 relates to restrictive lung function impairment in systemic sclerosis
    Grethe Neumann Andersen
    Department of Rheumatology, University Hospital of Umea, Umea, Sweden
    Respir Med 101:2199-206. 2007
    ..The present study suggests that MMP-9 plays a pathophysiological role in the remodelling in ILD and lung fibrosis associated with SSc, and may represent a new therapeutic target in this condition...
  30. doi request reprint Lipid mediator profiles differ between lung compartments in asthmatic and healthy humans
    Nirina Larsson
    Division of Medicine, Umea University, Umea
    Eur Respir J 43:453-63. 2014
    ..Specific protocols for sampling proximal and distal airways separately should be employed for lipid mediator studies. ..
  31. pmc Experimental exposure to diesel exhaust increases arterial stiffness in man
    Magnus Lundback
    Department of Respiratory Medicine and Allergy, University Hospital, Umea, Sweden
    Part Fibre Toxicol 6:7. 2009
    ..abstract:..
  32. ncbi request reprint LPS-induced bronchoalveolar neutrophilia; effects of salmeterol treatment
    Annika Wallin
    Department of Respiratory Medicine and Allergy, University Hospital, Umeå 90185, Sweden
    Respir Med 98:1087-92. 2004
    ..01). The neutrophilia was present irrespective of the LPS inhalation was preceded by placebo or Salmeterol. This experimental study could not confirm any modulating effect of Salmeterol on LPS-induced airway neutrophilia...
  33. ncbi request reprint Lung effects during a generalized Shwartzman reaction and therapeutic intervention with dexamethasone or vitamin E
    David Rocksen
    Department of Medical Countermeasures, Divison of NBC Defence, Swedish Defence Research Agency, Umea, Sweden
    Shock 22:482-90. 2004
    ..We suggest that this model can be used for studies of pathogenesis and therapeutic prevention of acute respiratory failure...