Gunnar Ronquist

Summary

Affiliation: University Hospital
Country: Sweden

Publications

  1. ncbi Human epidermal energy metabolism is functionally anaerobic
    Gunnar Ronquist
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
    Exp Dermatol 12:572-9. 2003
  2. ncbi The Janus-faced nature of prostasomes: their pluripotency favours the normal reproductive process and malignant prostate growth
    G Ronquist
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Prostate Cancer Prostatic Dis 7:21-31. 2004
  3. ncbi Imbalance of plasma membrane ion leak and pump relationship as a new aetiological basis of certain disease states
    G Ronquist
    Department of Clinical Chemistry, University Hospital, Uppsala, Sweden
    J Intern Med 254:517-26. 2003
  4. ncbi Prothrombotic effects of prostasomes isolated from prostatic cancer cell lines and seminal plasma
    Adil A Babiker
    Department of Oncology, Radiology, and Clinical Immunology, Division of Clinical Immunology, Rudbeck Laboratory C5, Uppsala, Sweden
    Semin Thromb Hemost 33:80-6. 2007
  5. doi Mapping pro- and antiangiogenic factors on the surface of prostasomes of normal and malignant cell origin
    Adil A Babiker
    Rudbeck Laboratory C5, Department of Oncology, Uppsala, Sweden
    Prostate 70:834-47. 2010
  6. ncbi Prothrombotic effect of prostasomes of metastatic cell and seminal origin
    Adil A Babiker
    Department of Oncology, Radiology, and Clinical Immunology, Division of Clinical Immunology, Rudbeck Laboratory C5, Uppsala, Sweden
    Prostate 67:378-88. 2007
  7. pmc Secretions from seminal vesicles lack characteristic markers for prostasomes
    Göran Sahlén
    Department of Urology, University Hospital, Uppsala, Sweden
    Ups J Med Sci 115:107-12. 2010
  8. ncbi Antiprostasome antibodies: possible serum markers for prostate cancer metastasizing liability
    Anders Larsson
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Uppsala, Sweden
    Urol Oncol 24:195-200. 2006
  9. doi Prostasomal DNA characterization and transfer into human sperm
    Göran K Ronquist
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Mol Reprod Dev 78:467-76. 2011
  10. ncbi Prostasomes are secreted from poorly differentiated cells of prostate cancer metastases
    Göran Sahlén
    Department of Urology, University Hospital, Uppsala, Sweden
    Prostate 61:291-7. 2004

Collaborators

Detail Information

Publications47

  1. ncbi Human epidermal energy metabolism is functionally anaerobic
    Gunnar Ronquist
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
    Exp Dermatol 12:572-9. 2003
    ....
  2. ncbi The Janus-faced nature of prostasomes: their pluripotency favours the normal reproductive process and malignant prostate growth
    G Ronquist
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Prostate Cancer Prostatic Dis 7:21-31. 2004
    ....
  3. ncbi Imbalance of plasma membrane ion leak and pump relationship as a new aetiological basis of certain disease states
    G Ronquist
    Department of Clinical Chemistry, University Hospital, Uppsala, Sweden
    J Intern Med 254:517-26. 2003
    ....
  4. ncbi Prothrombotic effects of prostasomes isolated from prostatic cancer cell lines and seminal plasma
    Adil A Babiker
    Department of Oncology, Radiology, and Clinical Immunology, Division of Clinical Immunology, Rudbeck Laboratory C5, Uppsala, Sweden
    Semin Thromb Hemost 33:80-6. 2007
    ....
  5. doi Mapping pro- and antiangiogenic factors on the surface of prostasomes of normal and malignant cell origin
    Adil A Babiker
    Rudbeck Laboratory C5, Department of Oncology, Uppsala, Sweden
    Prostate 70:834-47. 2010
    ..We investigated the expression of selected angiogenic and anti-angiogenic factors on the surface of prostasomes of different origins as well as the direct effect of prostasomes on angiogenesis...
  6. ncbi Prothrombotic effect of prostasomes of metastatic cell and seminal origin
    Adil A Babiker
    Department of Oncology, Radiology, and Clinical Immunology, Division of Clinical Immunology, Rudbeck Laboratory C5, Uppsala, Sweden
    Prostate 67:378-88. 2007
    ..Seminal prostasomes contain high amounts of Tissue Factor (TF) but no studies of TF on malignant cell prostasomes have been made. Here we compare the expression, phosphorylation, and function of TF on prostasomes of different origin...
  7. pmc Secretions from seminal vesicles lack characteristic markers for prostasomes
    Göran Sahlén
    Department of Urology, University Hospital, Uppsala, Sweden
    Ups J Med Sci 115:107-12. 2010
    ..Therefore, we have compared the secretion of the vesicles with that of the prostate using biochemical and ultrastructural techniques...
  8. ncbi Antiprostasome antibodies: possible serum markers for prostate cancer metastasizing liability
    Anders Larsson
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Uppsala, Sweden
    Urol Oncol 24:195-200. 2006
    ..035) and pT (P = 0.025). These results indicate that the antiprostasome antibody titer in serum may be a novel marker for prostate cancer liability to metastasize...
  9. doi Prostasomal DNA characterization and transfer into human sperm
    Göran K Ronquist
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Mol Reprod Dev 78:467-76. 2011
    ..Fluorescence microscopy of slices in the center of 14 optical slides of the sperm head displayed an even fluorescence rather than a halo-like one, indicating DNA-uptake rather than just binding along the sperm head membrane...
  10. ncbi Prostasomes are secreted from poorly differentiated cells of prostate cancer metastases
    Göran Sahlén
    Department of Urology, University Hospital, Uppsala, Sweden
    Prostate 61:291-7. 2004
    ..To find out whether these prostasomes are secreted into extracellular sites of the metastases, we used electron microscopy...
  11. ncbi Flow cytometric technique for determination of prostasomal quantity, size and expression of CD10, CD13, CD26 and CD59 in human seminal plasma
    Lena Carlsson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Int J Androl 29:331-8. 2006
    ..Flow cytometry is a practical way to study prostasomes in seminal fluid without prior separation. This is a new technique for evaluation of the role of prostasomes and their functions in male reproductive physiology...
  12. ncbi Mode of growth determines differential expression of prostasomes in cultures of prostate cancer cell lines and opens for studies of prostasome gene expression
    Lena Carlsson
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
    Ups J Med Sci 111:293-301. 2006
    ..Thus it should be possible to apply cDNAmicroarray analyses for characterizing the genes which are active at the cellular expression of prostasomes and then deduce the prostasome antigens...
  13. doi Human prostasomes contain chromosomal DNA
    K Göran Ronquist
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
    Prostate 69:737-43. 2009
    ..The aim of this study was to perform a comprehensive evaluation of the occurrence of DNA in human prostasomes...
  14. pmc Metabolic stress-like condition can be induced by prolonged strenuous exercise in athletes
    Stefan Branth
    Department of Medical Sciences, Clinical Chemistry, University of Uppsala, Uppsala, Sweden
    Ups J Med Sci 114:12-25. 2009
    ....
  15. doi Prostasomes from four different species are able to produce extracellular adenosine triphosphate (ATP)
    K Göran Ronquist
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Biochim Biophys Acta 1830:4604-10. 2013
    ..Prostasomes in their extracellular context are thought to play a crucial role in fertilization...
  16. doi Prostasomes are heterogeneous regarding size and appearance but affiliated to one DNA-containing exosome family
    Göran K Ronquist
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Prostate 72:1736-45. 2012
    ..Prostasomes are formed in a similar way as exosomes but are heterogeneous as regards size and appearance. Like exosomes they are thought to be mediators of intercellular communication...
  17. doi Biochemical characterization of stallion prostasomes and comparison to their human counterparts
    Göran K Ronquist
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
    Syst Biol Reprod Med 59:297-303. 2013
    ..We present some new proteins of horse prostasomes not found in their human counterparts. Further studies are warranted to reveal the function of these proteins. ..
  18. doi Captopril may reduce biochemical (prostate-specific antigen) failure following radical prostatectomy for clinically localized prostate cancer
    Gunnar Ronquist
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Scand J Urol Nephrol 43:32-6. 2009
    ..This study therefore investigated whether captopril given postoperatively had any preventive effect on biochemical recurrence for patients treated with radical prostatectomy...
  19. doi Human prostasomes express glycolytic enzymes with capacity for ATP production
    K Göran Ronquist
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Am J Physiol Endocrinol Metab 304:E576-82. 2013
    ..There is no clear-cut function linked to this subset of prostasomal proteins, but some possible roles are discussed...
  20. ncbi Prostasome-derived proteins capable of eliciting an immune response in prostate cancer patients
    Karl Göran Ronquist
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
    Int J Cancer 119:847-53. 2006
    ..These immunogenic prostasomal proteins could be appropriate target molecules for specific immunotherapy of prostate cancer patients...
  21. ncbi Dominant prostasome immunogens for sperm-agglutinating autoantibodies of infertile men
    Lena Carlsson
    Department of Medical Sciences, University Hospital, S 751 85 Uppsala, Sweden
    J Androl 25:699-705. 2004
    ....
  22. ncbi Proteomic analysis of prostate cancer metastasis-derived prostasomes
    K Göran Ronquist
    Department of Medical Sciences, Clinical Chemistry, University Hospital SE 751 85 Uppsala, Sweden
    Anticancer Res 30:285-90. 2010
    ..The aim of the present investigation was to conduct a proteomic analysis of metastasis-derived prostasomes...
  23. ncbi Microdialysis and electromyography of experimental muscle fatigue in healthy volunteers and patients with mitochondrial myopathy
    Hans W Axelson
    Department of Neuroscience, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Muscle Nerve 26:520-6. 2002
    ..With the exercise protocol used, however, it was not possible to demonstrate any biochemical difference between healthy controls and patients with mitochondrial myopathy...
  24. ncbi [Analysis of beta-"trace" protein detects leakage of cerebrospinal fluid. Quickly, safely and cheaply]
    Anders Larsson
    Akademiska laboratoriet, Klinisk kemi och farmakologi, Akademiska sjukhuset, Uppsala
    Lakartidningen 100:943-5. 2003
    ..Analysis of beta-trace protein via a nephelometric assay is a valuable test for the identification of cerebrospinal fluid in rhinorrhea or otorrhea...
  25. ncbi Ultrastructure of the secretion of prostasomes from benign and malignant epithelial cells in the prostate
    Göran E Sahlén
    Department of Urology, University Hospital, Uppsala, Sweden
    Prostate 53:192-9. 2002
    ..Due to the small size of the prostasomes, we have used electron microscopy for evaluating the production and distribution of prostasomes in benign and neoplastic cells of the prostate...
  26. ncbi Characteristics of human prostasomes isolated from three different sources
    Lena Carlsson
    Department of Medical Sciences, Clinical Chemistry Unit, University Hospital, Uppsala, Sweden
    Prostate 54:322-30. 2003
    ..Prostasomes are organelles secreted by human prostate epithelial cells and appear freely in semen. Most prostasomal functional and biochemical characteristics have been settled on basis of seminal prostasomes (SP)...
  27. ncbi Expression of CYP4F12 in gastrointestinal and urogenital epithelia
    Katarina Stark
    Department of Pharmaceutical Biosciences, Division of Biochemical Pharmacology, Uppsala University, Uppsala, Sweden
    Basic Clin Pharmacol Toxicol 94:177-83. 2004
    ..We conclude that CYP4F12 is widely distributed in gastrointestinal and urogenital epithelia and exhibits a narrow substrate specificity...
  28. ncbi Overexpression of ecto-protein kinases in prostasomes of metastatic cell origin
    Adil A Babiker
    Department of Oncology, Radiology, and Clinical Immunology, Division of Clinical Immunology, Rudbeck Laboratory C5, Uppsala, Sweden
    Prostate 66:675-86. 2006
    ..They express numerous enzymes whose physiological roles have so far not been fully evaluated. In this study, we investigated the expression and function of prostasomal protein kinases and ATPase...
  29. doi Increased cerebral uptake of [18F]fluoro-deoxyglucose but not [1-14C]glucose early following traumatic brain injury in rats
    Niklas Marklund
    Department of Neuroscience, Uppsala University CSO, Imanet, Uppsala, Sweden
    J Neurotrauma 26:1281-93. 2009
    ..These results should be considered when interpreting results obtained using FDG for the estimation of lCMR(Glc) early following experimental TBI...
  30. doi Role of exosomes in myocardial remodeling
    Anders Waldenstrom
    From the Department of Cardiology, Heart Centre, and Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden A W and Department of Medical Sciences, Clinical Chemistry, University Hospital of Uppsala, Uppsala University, Uppsala, Sweden G R
    Circ Res 114:315-24. 2014
    ..Future clinical use of exosomes in diagnosis, monitoring disease progress, and treatment is promising. ..
  31. ncbi Association between captopril, other antihypertensive drugs and risk of prostate cancer
    Gunnar Ronquist
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
    Prostate 58:50-6. 2004
    ..There has been some debate on the existence of an association between hypertension, antihypertensive medications and cancer risk...
  32. doi Lactate distribution in culture medium of human myometrial biopsies incubated under different conditions
    Helena Akerud
    Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden
    Am J Physiol Endocrinol Metab 297:E1414-9. 2009
    ..Human myometrial cells produced and delivered lactate to the extracellular medium under both anaerobic and aerobic conditions. The delivery was mediated by lactate carriers...
  33. ncbi Development of abdominal fat and incipient metabolic syndrome in young healthy men exposed to long-term stress
    Stefan Branth
    Department of Medical Sciences, Section of Nutrition, University of Uppsala, University Hospital of Uppsala, SE 751 85 Uppsala, Sweden
    Nutr Metab Cardiovasc Dis 17:427-35. 2007
    ..The aim was to study the effects of long-term stress on different features of the metabolic syndrome (MES) in formerly non-obese healthy young males during 5 months of defined conditions...
  34. ncbi Unique antitumour effects of L-2,4 diaminobutyric acid on cultured hepatoma cells
    Per Jonas Blind
    Department of Surgery, University Hospital, Lund University, SE 221 45 Lund, Sweden
    Anticancer Res 23:1245-8. 2003
    ..This was combined with a tumour cell energy crisis in attempts to restore the Na(+)-gradient...
  35. ncbi [Prostasomes and exosomes--cell messengers with therapeutic potentials]
    Gunnar Ronquist
    Institutionen för medicinska vetenskaper, Klinisk kemi, Akademiska sjukhuset, Uppsala
    Lakartidningen 104:784-6. 2007
  36. ncbi Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardium
    Mohammad Kavianipour
    Department of Public Health and Clinical Medicine, Umea University Hospital, Umea, Sweden
    Peptides 24:569-78. 2003
    ..We conclude that rGLP-1 altered myocardial glucose utilization during ischemia and reperfusion. It did not exert any untoward hemodynamic effects...
  37. ncbi Glycogenosis type VII (Tarui's disease): diagnostic considerations and late sequelae
    Gunnar Ronquist
    South Med J 95:1361-2. 2002
  38. ncbi Antiprostasome antibody titres in benign and malignant prostate disease
    Alba Minelli
    Dipartimento di Medicina Sperimentale Scienze Biochimiche, Sezione di Biochimica Cellulare, Universita di Perugia, Perugia, Italy
    Anticancer Res 25:4399-402. 2005
    ..Prostasomes are postulated to be shed into the blood circulation in prostate cancer patients, where they may cause an immune response...
  39. ncbi Ecto-diadenosine polyphosphates hydrolase activity on human prostasomes
    Alba Minelli
    Dipartimento di Scienze Biochimiche e Biotecnologie Molecolari, Sezione di Biochimica Cellulare, Universita di Perugia, Via del Giochetto, Perugia, Italy
    Prostate 51:1-9. 2002
    ..The present work deals with the identification and partial characterization of ecto-diadenosine polyphosphates hydrolase on human prostasomes...
  40. ncbi New mechanism for amino acid influx into human epidermal Langerhans cells: L-dopa/proton counter-transport system
    Bengt Falck
    Department of Physiology, Lund University, Lund, Sweden
    Exp Dermatol 12:602-9. 2003
    ..L-dopa is not metabolized by LCs but can rapidly be dislocated to the intercellular space by certain extracellular amino acids, i.e. LCs can profit by L-dopa in a dualistic way, altogether a remarkable biological phenomenon...
  41. ncbi Transfer of functional prostasomal CD59 of metastatic prostatic cancer cell origin protects cells against complement attack
    Adil A Babiker
    Department of Radiology, Oncology, and Clinical Immunology, Division of Clinical Immunology, The Rudbeck Laboratory C5, SE 751 85 Uppsala, Sweden
    Prostate 62:105-14. 2005
    ..They express the glycosylphosphatidylinositol (GPI)-anchored complement regulatory protein CD59, which has been shown to be transferred to spermatozoa and erythrocytes...
  42. ncbi [An unusual type of hemolysis in Tarui disease in two families originated in the county of Vasterbotten]
    Olle Rudolphi
    Norrlands Universitetssjukhus, Umea
    Lakartidningen 103:657-60. 2006
  43. ncbi The contribution of Ca+ calmodulin activation of human erythrocyte AMP deaminase (isoform E) to the erythrocyte metabolic dysregulation of familial phosphofructokinase deficiency
    Richard L Sabina
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Haematologica 91:652-5. 2006
    ..Therapies directed against activated isoform E may be beneficial in this compensated anemia...
  44. ncbi Metabolic manipulation of glioblastoma in vivo by retrograde microdialysis of L-2, 4 diaminobutyric acid (DAB)
    A Tommy Bergenheim
    Department of Neurosurgery, Umea University Hospital, SE 901 85, Umea, Sweden
    J Neurooncol 80:285-93. 2006
    ..To study the metabolic effects in vivo of L-2, 4 diaminobutyric acid (DAB) administered by retrograde microdialysis in glioblastoma and to evaluate the feasibility of the technique...
  45. ncbi Possible immunoprotective and angiogenesis-promoting roles for malignant cell-derived prostasomes: a new paradigm for prostatic cancer?
    Kristina Nilsson Ekdahl
    Department of Chemistry and Biomedical Sciences, University of Kalmar, Sweden
    Adv Exp Med Biol 586:107-19. 2006
  46. ncbi Energy metabolic changes in the early post-injury period following traumatic brain injury in rats
    Niklas Marklund
    Department of Neuroscience, Neurosurgery, Uppsala University Hospital, SE 75185 Uppsala, Sweden
    Neurochem Res 31:1085-93. 2006
    ..05). The energy-requiring secondary injury cascades that occur early post-injury do not challenge the brain tissue to the extent of ATP depletion and may provide a window of opportunity for therapeutic intervention...
  47. ncbi Transfer of prostasomal CD59 to CD59-deficient red blood cells results in protection against complement-mediated hemolysis
    Adil A Babiker
    Department of Clinical Chemistry, University of Uppsala, Sweden
    Am J Reprod Immunol 47:183-92. 2002
    ....