Felix Mitelman

Summary

Affiliation: University Hospital
Country: Sweden

Publications

  1. ncbi request reprint Recurrent chromosome aberrations in cancer
    F Mitelman
    Department of Clinical Genetics, University Hospital, SE 221 85, Lund, Sweden
    Mutat Res 462:247-53. 2000
  2. ncbi request reprint Prevalence estimates of recurrent balanced cytogenetic aberrations and gene fusions in unselected patients with neoplastic disorders
    Felix Mitelman
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 43:350-66. 2005
  3. ncbi request reprint Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer
    Felix Mitelman
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Nat Genet 36:331-4. 2004
  4. pmc Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity
    Ylva Stewénius
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Proc Natl Acad Sci U S A 102:5541-6. 2005
  5. ncbi request reprint MDS/AML-associated cytogenetic abnormalities in multiple myeloma and monoclonal gammopathy of undetermined significance: evidence for frequent de novo occurrence and multipotent stem cell involvement of del(20q)
    Therese Nilsson
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 41:223-31. 2004
  6. ncbi request reprint A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23)
    Aikaterini Barbouti
    Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Cancer Res 63:1202-6. 2003
  7. ncbi request reprint Dissecting karyotypic patterns in renal cell carcinoma: an analysis of the accumulated cytogenetic data
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Cancer Genet Cytogenet 153:1-9. 2004
  8. ncbi request reprint High frequencies of chromosomal aberrations in multiple myeloma and monoclonal gammopathy of undetermined significance in direct chromosome preparation
    Therese Nilsson
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Br J Haematol 126:487-94. 2004
  9. ncbi request reprint Statistical dissection of cytogenetic patterns in lung cancer reveals multiple modes of karyotypic evolution independent of histological classification
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Cancer Genet Cytogenet 154:99-109. 2004
  10. ncbi request reprint Wilms tumors develop through two distinct karyotypic pathways
    Mattias Hoglund
    Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Cancer Genet Cytogenet 150:9-15. 2004

Detail Information

Publications48

  1. ncbi request reprint Recurrent chromosome aberrations in cancer
    F Mitelman
    Department of Clinical Genetics, University Hospital, SE 221 85, Lund, Sweden
    Mutat Res 462:247-53. 2000
    ..Data obtained during recent years strongly suggest that corresponding breakthroughs will be achieved in solid tumors within a not-too-distant future...
  2. ncbi request reprint Prevalence estimates of recurrent balanced cytogenetic aberrations and gene fusions in unselected patients with neoplastic disorders
    Felix Mitelman
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 43:350-66. 2005
    ....
  3. ncbi request reprint Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer
    Felix Mitelman
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Nat Genet 36:331-4. 2004
    ..Hence, there may not be any fundamental tissue-specific differences in the genetic mechanisms by which neoplasia is initiated...
  4. pmc Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity
    Ylva Stewénius
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Proc Natl Acad Sci U S A 102:5541-6. 2005
    ..Bridging of telomere-deficient chromosomes could thus be a major mutational mechanism in colorectal cancer, whereas mitotic multipolarity appears to be a secondary phenomenon that rarely, if ever, contributes to clonal evolution...
  5. ncbi request reprint MDS/AML-associated cytogenetic abnormalities in multiple myeloma and monoclonal gammopathy of undetermined significance: evidence for frequent de novo occurrence and multipotent stem cell involvement of del(20q)
    Therese Nilsson
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 41:223-31. 2004
    ..The present data indicate that 20q- occurs in 10% of karyotypically abnormal MM/MGUS cases and that it might arise at a multipotent progenitor/stem cell level...
  6. ncbi request reprint A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23)
    Aikaterini Barbouti
    Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Cancer Res 63:1202-6. 2003
    ..The identified in-frame MSI2/HOXA9 fusion transcript retains both of the RNA recognition motif domains of MSI2, which is fused to the homeobox domain of HOXA9, and is likely to play an important role in the disease progression of CML...
  7. ncbi request reprint Dissecting karyotypic patterns in renal cell carcinoma: an analysis of the accumulated cytogenetic data
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Cancer Genet Cytogenet 153:1-9. 2004
    ..The analyses also revealed three possible cytogenetic subtypes of the papillary tumors, one characterized by the presence of +10, a second by +17 and +3q, and a third by +16, +20, and +12...
  8. ncbi request reprint High frequencies of chromosomal aberrations in multiple myeloma and monoclonal gammopathy of undetermined significance in direct chromosome preparation
    Therese Nilsson
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Br J Haematol 126:487-94. 2004
    ..Thus, cytogenetic and FISH analyses after DCP using 100-200 ng Colcemide/ml identified aberrations in most MM/MGUS/SMM, irrespective of PC percentages...
  9. ncbi request reprint Statistical dissection of cytogenetic patterns in lung cancer reveals multiple modes of karyotypic evolution independent of histological classification
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Cancer Genet Cytogenet 154:99-109. 2004
    ..No marked differences between the karyotypic profiles were found among morphologic subtypes, suggesting that lung cancer morphology is independent of the particular cytogenetic pathway operating in the tumor cells...
  10. ncbi request reprint Wilms tumors develop through two distinct karyotypic pathways
    Mattias Hoglund
    Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Cancer Genet Cytogenet 150:9-15. 2004
    ..We also show that these pathways are well separated and do not share a common set of late imbalances...
  11. ncbi request reprint Ovarian carcinoma develops through multiple modes of chromosomal evolution
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Cancer Res 63:3378-85. 2003
    ..This process was linked to the presence of imbalances characteristic for the 6q-/1q- pathway. The transition to Phase III involved triploidization and was also linked to the presence of the 6q-/1q- pathway...
  12. ncbi request reprint Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignancies
    Clelia T Storlazzi
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Hum Mol Genet 13:1479-85. 2004
    ..These results exclude MYC as the target gene and indicate that overexpression of C8FW may be the functionally important consequence of 8q24 amplicons in AML and MDS...
  13. ncbi request reprint Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13)
    Ioannis Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, Sweden
    Genes Chromosomes Cancer 36:107-12. 2003
    ..The present results, together with previous studies of NUP98/homeobox gene fusions, strongly indicate that NUP98/HOXC13 is of pathogenetic importance in t(11;12)-positive acute myeloid leukemia...
  14. pmc Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations
    Anna Andersson
    Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Proc Natl Acad Sci U S A 102:19069-74. 2005
    ....
  15. ncbi request reprint Statistical behavior of complex cancer karyotypes
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Genes Chromosomes Cancer 42:327-41. 2005
    ..The change in karyotypic orderliness at the transition from Phase I to Phase II/III was also shown by a drastic difference in karyotypic entropy...
  16. ncbi request reprint A model for karyotypic evolution in testicular germ cell tumors
    Attila Frigyesi
    Center for Mathematical Sciences, Mathematical Statistics, Lund University, Lund, Sweden
    Genes Chromosomes Cancer 40:172-8. 2004
    ..The results suggest that whole-chromosome changes originate from a multipolar cell division of a tetraploid cell, whereas imbalances caused by structural changes accumulate in a stepwise manner...
  17. ncbi request reprint Coping with complexity. multivariate analysis of tumor karyotypes
    Mattias Hoglund
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Cancer Genet Cytogenet 135:103-9. 2002
    ..By applying these methods on the chromosomal changes presently known, distinct subgroups have been identified among breast, kidney, bladder, colon, and brain tumors...
  18. ncbi request reprint Formation of der(19)t(1;19)(q23;p13) in acute lymphoblastic leukemia
    Kajsa Paulsson
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 42:144-8. 2005
    ....
  19. ncbi request reprint Clinical impact of internal tandem duplications and activating point mutations in FLT3 in acute myeloid leukemia in elderly patients
    Anna Andersson
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Eur J Haematol 72:307-13. 2004
    ..In the present study, the frequency and clinical relevance of FLT3 abnormalities were ascertained in a cohort of elderly AML patients...
  20. ncbi request reprint Statistical analyses of karyotypic complexity in head and neck squamous cell carcinoma
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Cancer Genet Cytogenet 150:1-8. 2004
    ..Two major cytogenetic pathways, one dominated by gains and another by losses, were identified by means of principal component analysis. These were initiated by +7 and by any of the aberrations 1p-, 3p-, or 7q-, respectively...
  21. ncbi request reprint Clinical and genetic studies of ETV6/ABL1-positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylate
    Aikaterini Barbouti
    Department of Clinical Genetics, Lund University Hospital, Sweden
    Br J Haematol 122:85-93. 2003
    ..This decreased expression of wild-type ETV6 may have been a contributory factor for the relapse...
  22. ncbi request reprint Ewing tumours and synovial sarcomas have critical features of karyotype evolution in common with epithelial tumours
    Mattias Hoglund
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Int J Cancer 116:401-6. 2005
    ....
  23. ncbi request reprint Dissecting karyotypic patterns in colorectal tumors: two distinct but overlapping pathways in the adenoma-carcinoma transition
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Cancer Res 62:5939-46. 2002
    ..We also show that the adenoma-carcinoma transition in the 1p- pathway is strongly linked to karyoytypic evolution, whereas the +7 pathway is not, and that the cytogenetic pathways are separated at both early and late stages...
  24. ncbi request reprint Dissecting karyotypic patterns in malignant melanomas: temporal clustering of losses and gains in melanoma karyotypic evolution
    Mattias Hoglund
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Int J Cancer 108:57-65. 2004
    ....
  25. pmc The breakpoint region of the most common isochromosome, i(17q), in human neoplasia is characterized by a complex genomic architecture with large, palindromic, low-copy repeats
    Aikaterini Barbouti
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Am J Hum Genet 74:1-10. 2004
    ....
  26. ncbi request reprint Identification of cytogenetic subgroups and karyotypic pathways of clonal evolution in follicular lymphomas
    Mattias Hoglund
    Department of Clinical Genetics, University of Lund, Sweden
    Genes Chromosomes Cancer 39:195-204. 2004
    ..The clinical implications of these pathways of clonal evolution need to be examined on a prospective basis in a large cohort of FLs...
  27. doi request reprint Disease-associated patterns of disomic chromosomes in hyperhaploid neoplasms
    Nils Mandahl
    Department of Clinical Genetics, University and Regional Laboratories, Skane University Hospital, Lund University, Lund, Sweden
    Genes Chromosomes Cancer 51:536-44. 2012
    ..The present findings indicate that retention of disomy for some chromosomes is pathogenetically important and that the chromosome(s) maintained in two copies is related to cell type or histological context...
  28. ncbi request reprint MLL/GRAF fusion in an infant acute monocytic leukemia (AML M5b) with a cytogenetically cryptic ins(5;11)(q31;q23q23)
    Ioannis Panagopoulos
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Genes Chromosomes Cancer 41:400-4. 2004
    ..On the basis of the now-reported two cases with MLL/GRAF, we conclude that this transcript--but not the reciprocal one--characterizes a rare genetic subgroup of infant AML...
  29. ncbi request reprint Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression
    Aikaterini Barbouti
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 35:127-37. 2002
    ..Altogether, a refined karyotypic description was achieved in 12 (36%) of the 33 investigated cases, illustrating the value of using multicolor FISH for identifying pathogenetically important aberrations in CML AP/BC...
  30. ncbi request reprint The impact of translocations and gene fusions on cancer causation
    Felix Mitelman
    Lund University, Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Nat Rev Cancer 7:233-45. 2007
    ..With the advent of new and powerful investigative tools that enable the detection of cytogenetically cryptic rearrangements, this proportion is likely to increase substantially...
  31. pmc Generation of trisomies in cancer cells by multipolar mitosis and incomplete cytokinesis
    David Gisselsson
    Department of Clinical Genetics, Lund University, University and Regional Laboratories, University Hospital, SE 221 85 Lund, Sweden
    Proc Natl Acad Sci U S A 107:20489-93. 2010
    ....
  32. pmc The correlation pattern of acquired copy number changes in 164 ETV6/RUNX1-positive childhood acute lymphoblastic leukemias
    Henrik Lilljebjörn
    Department of Clinical Genetics, University and Regional Laboratories, Skane University Hospital, Lund University, Lund, Sweden
    Hum Mol Genet 19:3150-8. 2010
    ..Furthermore, oncogenetic tree models identified ETV6, CDKN2A/B, PAX5, del(6q) and +16 as possible early events in the leukemogenic process...
  33. ncbi request reprint Cytogenetic and morphologic subgroups of myelodysplastic syndromes in relation to occupational and hobby exposures
    Maria Albin
    Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
    Scand J Work Environ Health 29:378-87. 2003
    ..This study investigated the association between occupational and hobby exposure and the risk of myelodysplastic syndromes (MDS) while focusing on differential patterns of clonal chromosome aberrations and morphologic subgroups...
  34. ncbi request reprint A pooled analysis of karyotypic patterns, breakpoints and imbalances in 783 cytogenetically abnormal multiple myelomas reveals frequently involved chromosome segments as well as significant age- and sex-related differences
    Therese Nilsson
    Department of Clinical Genetics, Lund University Hospital, Sweden
    Br J Haematol 120:960-9. 2003
    ..The present findings strongly suggest that some karyotypic features of MM are influenced by endogenous and/or exogenous factors...
  35. ncbi request reprint Genomic characterization of MOZ/CBP and CBP/MOZ chimeras in acute myeloid leukemia suggests the involvement of a damage-repair mechanism in the origin of the t(8;16)(p11;p13)
    Ioannis Panagopoulos
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 36:90-8. 2003
    ..Thus, the t(8;16) does not originate through a simple end-to-end fusion. The findings of multiple breaks and rearrangements rather suggest the involvement of a damage-repair mechanism in the origin of this translocation...
  36. ncbi request reprint Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute lymphoblastic leukemia
    Bertil Johansson
    Deaprtment of Clinical Genetics, Lund University Hospital, Sweden
    Ann Med 36:492-503. 2004
    ..Here, we summarize and review the cytogenetic features of childhood and adult ALL, with emphasis on their molecular genetic consequences and their clinical impact...
  37. ncbi request reprint Expression of NUP98/TOP1, but not of TOP1/NUP98, in a treatment-related myelodysplastic syndrome with t(10;20;11)(q24;q11;p15)
    Ioannis Panagopoulos
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 34:249-54. 2002
    ....
  38. ncbi request reprint Cytogenetic and molecular genetic evolution of chronic myeloid leukemia
    Bertil Johansson
    Department of Clinical Genetics, Lund University Hospital, Sweden
    Acta Haematol 107:76-94. 2002
    ..g., i(17q), have repeatedly been shown to be ominous. However, the clinical impact of additional cytogenetic and molecular genetic aberrations is most likely modified by the treatment modalities used...
  39. ncbi request reprint Formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia
    Kajsa Paulsson
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Blood 102:3010-5. 2003
    ..0703). Thus, the present results indicate that imprinting is not pathogenetically important in hyperdiploid childhood ALL, with the possible exception of the observed parental skewness of +8 and +14...
  40. ncbi request reprint Prognostically important chromosomal aberrations in soft tissue sarcomas: a report of the Chromosomes and Morphology (CHAMP) Study Group
    Fredrik Mertens
    Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Cancer Res 62:3980-4. 2002
    ..Furthermore, our results point to specific areas of the genome harboring genes that may influence the metastatic potential of sarcoma cells...
  41. ncbi request reprint Multivariate analysis of chromosomal imbalances in breast cancer delineates cytogenetic pathways and reveals complex relationships among imbalances
    Mattias Hoglund
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Cancer Res 62:2675-80. 2002
    ..Although the cytogenetic pathways are well separated at earlier stages, they later converge and include a common set of late imbalances...
  42. ncbi request reprint RT-PCR analysis of acute myeloid leukemia with t(8;16)(p11;p13): identification of a novel MOZ/CBP transcript and absence of CBP/MOZ expression
    Ioannis Panagopoulos
    Genes Chromosomes Cancer 35:372-4. 2002
  43. ncbi request reprint Power law distribution of chromosome aberrations in cancer
    Attila Frigyesi
    Centre for Mathematical Sciences, Mathematical Statistics, Lund University, SE 221 85 Lund, Sweden
    Cancer Res 63:7094-7. 2003
    ..Because almost identical power law distributions are seen in breast, colorectal, and renal cell carcinomas we suggest that the obtained distributions are consequences of a common mechanism operating in malignant epithelial tumors...
  44. ncbi request reprint ISCN (2005) is not acceptable for describing clonal evolution in cancer
    Felix Mitelman
    Genes Chromosomes Cancer 46:213-4. 2007
  45. ncbi request reprint Tumor karyotype predicts clinical outcome in colorectal cancer patients
    Georgia Bardi
    Department of Genetics, G Papanikolaou Research Center, Saint Savas Oncological Hospital of Athens, Greece
    J Clin Oncol 22:2623-34. 2004
    ..To investigate the prognostic value of the overall karyotypic features and specific chromosome aberrations in colorectal cancer (CRC)...
  46. ncbi request reprint Unique balanced chromosome abnormalities in treatment-related myelodysplastic syndromes and acute myeloid leukemia: report from an international workshop
    Harold J Olney
    Section of Hematology Oncology, University of Chicago, Chicago, Illinois, USA
    Genes Chromosomes Cancer 33:413-23. 2002
    ..Thus, this group of patients appears to be more similar to the typical t-MDS/t-AML patients, with complex karyotypes as well as chromosome 5 and 7 abnormalities, than to those with recurrent balanced rearrangements...
  47. doi request reprint Molecular screening for new fusion genes in cancer
    Sverre Heim
    Nat Genet 40:685-6. 2008
  48. ncbi request reprint Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group
    Giovanni Tallini
    Department of Pathology, Yale University School of Medicine, New Haven, USA
    J Pathol 196:194-203. 2002
    ..They are associated with malignancy/tumour grade as well as with specific diagnoses in many cases, and can therefore be of potential value for tumour typing...