Johnny Ludvigsson

Summary

Affiliation: University Hospital
Country: Sweden

Publications

  1. doi request reprint Therapy with GAD in diabetes
    Johnny Ludvigsson
    Division of Pediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Diabetes Metab Res Rev 25:307-15. 2009
  2. ncbi request reprint Combination therapy for preservation of beta cell function in Type 1 diabetes: new attitudes and strategies are needed!
    Johnny Ludvigsson
    Division of Pediatrics, County Council of Ostergotland, and Department of Clinical and Experimental Medicine, Linkoping University, Sweden Electronic address
    Immunol Lett 159:30-5. 2014
  3. doi request reprint Does modern high standard life style cause type 1 diabetes in children?
    Johnny Ludvigsson
    Linkoping University, Div of Pediatrics, Dept of Clin Exp Med, University Hospital, Linkoping, SE, Sweden
    Diabetes Metab Res Rev 29:161-5. 2013
  4. ncbi request reprint Novel therapies in the management of type I diabetes mellitus
    J Ludvigsson
    Division of Pediatrics, Department of Clinical of Experimental Medicine, Linkoping University, Linkoping, Sweden
    Panminerva Med 54:257-70. 2012
  5. ncbi request reprint C-peptide in the classification of diabetes in children and adolescents
    J Ludvigsson
    Division of Pediatrics and Diabetes Research Center, Department of Clinical and Experimental Medicine, Linkoping University Hospital, Linkoping, Sweden
    Pediatr Diabetes 13:45-50. 2012
  6. pmc Web 2.0 systems supporting childhood chronic disease management: a pattern language representation of a general architecture
    Toomas Timpka
    Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
    BMC Med Inform Decis Mak 8:54. 2008
  7. pmc Cortisol in hair measured in young adults - a biomarker of major life stressors?
    Jerker Karlén
    Department of Medical and Health Sciences, Division of Community Medicine, Linkoping University, SE 581 83 Linkoping, Sweden
    BMC Clin Pathol 11:12. 2011
  8. ncbi request reprint [Interns positive to currently used written tests]
    Johnny Ludvigsson
    Institutionen för klinisk och experimentell medicin, Hälsouniversitetet, Linkoping
    Lakartidningen 105:2580-1. 2008
  9. ncbi request reprint Prevention of hypoglycaemia in diabetic children and adolescents
    J Ludvigsson
    Division of Pediatrics, Dept of Health and Environment, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Diabetes Nutr Metab 15:395-9; discussion 399-402. 2002
  10. ncbi request reprint Continuous subcutaneous glucose monitoring improved metabolic control in pediatric patients with type 1 diabetes: a controlled crossover study
    Johnny Ludvigsson
    Department of Pediatrics, University Hospital, Linköping and Central Hospital, Uddevalla, Sweden
    Pediatrics 111:933-8. 2003

Detail Information

Publications133 found, 100 shown here

  1. doi request reprint Therapy with GAD in diabetes
    Johnny Ludvigsson
    Division of Pediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Diabetes Metab Res Rev 25:307-15. 2009
    ..With this promising background further studies are on their way, both intervention in newly diagnosed type 1 diabetic patients, and trials to prevent the disease...
  2. ncbi request reprint Combination therapy for preservation of beta cell function in Type 1 diabetes: new attitudes and strategies are needed!
    Johnny Ludvigsson
    Division of Pediatrics, County Council of Ostergotland, and Department of Clinical and Experimental Medicine, Linkoping University, Sweden Electronic address
    Immunol Lett 159:30-5. 2014
    ..Regimens should be elaborated and first tried in those groups of patients where response can be expected to be best, and thereafter adjusted to increase efficacy step-wise, and in broader patient categories. ..
  3. doi request reprint Does modern high standard life style cause type 1 diabetes in children?
    Johnny Ludvigsson
    Linkoping University, Div of Pediatrics, Dept of Clin Exp Med, University Hospital, Linkoping, SE, Sweden
    Diabetes Metab Res Rev 29:161-5. 2013
    ..Several large epidemiological studies, mainly restricted to children with increased genetic risk for type 1 diabetes, have so far given no clue...
  4. ncbi request reprint Novel therapies in the management of type I diabetes mellitus
    J Ludvigsson
    Division of Pediatrics, Department of Clinical of Experimental Medicine, Linkoping University, Linkoping, Sweden
    Panminerva Med 54:257-70. 2012
    ..We need to learn how to treat subgroups of patients. Gradually a more individualized treatment may become successful...
  5. ncbi request reprint C-peptide in the classification of diabetes in children and adolescents
    J Ludvigsson
    Division of Pediatrics and Diabetes Research Center, Department of Clinical and Experimental Medicine, Linkoping University Hospital, Linkoping, Sweden
    Pediatr Diabetes 13:45-50. 2012
    ..To report C-peptide results in newly diagnosed patients and the relation to clinical diagnosis of diabetes...
  6. pmc Web 2.0 systems supporting childhood chronic disease management: a pattern language representation of a general architecture
    Toomas Timpka
    Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
    BMC Med Inform Decis Mak 8:54. 2008
    ....
  7. pmc Cortisol in hair measured in young adults - a biomarker of major life stressors?
    Jerker Karlén
    Department of Medical and Health Sciences, Division of Community Medicine, Linkoping University, SE 581 83 Linkoping, Sweden
    BMC Clin Pathol 11:12. 2011
    ..abstract:..
  8. ncbi request reprint [Interns positive to currently used written tests]
    Johnny Ludvigsson
    Institutionen för klinisk och experimentell medicin, Hälsouniversitetet, Linkoping
    Lakartidningen 105:2580-1. 2008
  9. ncbi request reprint Prevention of hypoglycaemia in diabetic children and adolescents
    J Ludvigsson
    Division of Pediatrics, Dept of Health and Environment, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Diabetes Nutr Metab 15:395-9; discussion 399-402. 2002
  10. ncbi request reprint Continuous subcutaneous glucose monitoring improved metabolic control in pediatric patients with type 1 diabetes: a controlled crossover study
    Johnny Ludvigsson
    Department of Pediatrics, University Hospital, Linköping and Central Hospital, Uddevalla, Sweden
    Pediatrics 111:933-8. 2003
    ..To improve metabolic control and prevent complications, both acute and late, we need to adjust treatment on the basis of the blood glucose (BG) profile, as not even the most active BG self-monitoring gives sufficient information...
  11. ncbi request reprint [Injudicious declarations about the benefits of alcohol!]
    Johnny Ludvigsson
    institutionen för molekylär och klinisk medicin, Halsouniversitetet i Linkoping
    Lakartidningen 100:1546-7. 2003
  12. ncbi request reprint GAD treatment and insulin secretion in recent-onset type 1 diabetes
    Johnny Ludvigsson
    Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    N Engl J Med 359:1909-20. 2008
    ..This trial assessed the ability of alum-formulated GAD (GAD-alum) to reverse recent-onset type 1 diabetes in patients 10 to 18 years of age...
  13. ncbi request reprint Cow-milk-free diet during last trimester of pregnancy does not influence diabetes-related autoantibodies in nondiabetic children
    Johnny Ludvigsson
    Department of Molecular and Clinical Medicine, Division of Pediatrics, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Ann N Y Acad Sci 1005:275-8. 2003
    ..Cow milk introduction between 3 and 6 months caused a transient increase in GADA at 6 months of age (p < 0.05). Children who developed atopic disease had significantly lower IA-2A at 6 months (p < 0.001)...
  14. ncbi request reprint Continuous insulin infusion (CSII) or modern type of multiple daily injections (MDI) in diabetic children and adolescents a critical review on a controversial issue
    Johnny Ludvigsson
    Division of Pediatrics and Diabetes Research Centre, Linkoping University, Linkoping, Sweden
    Pediatr Endocrinol Rev 5:666-78. 2007
    ..There is a common opinion that CSII is superior to MDI. CSII offers the most physiological insulin substitution...
  15. ncbi request reprint Prevention of adverse events in juvenile diabetes
    J Ludvigsson
    Diabetes Research Centre and Division of Pediatrics, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Minerva Pediatr 56:277-90. 2004
    ..Children with diabetes cannot expect a "normal" life, but they should be able to expect a long, active, exciting and happy life...
  16. ncbi request reprint Why diabetes incidence increases--a unifying theory
    Johnny Ludvigsson
    Division of Pediatrics, and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Ann N Y Acad Sci 1079:374-82. 2006
    ..However, we do know that low physical exercise, obesity, and stress, increases insulin demand resulting in insulin deficiency. Now we can therefore intervene to prevent the diabetic syndrome...
  17. ncbi request reprint Immune intervention at diagnosis--should we treat children to preserve beta-cell function?
    J Ludvigsson
    Department of Molecular and Clinical Science, Division of Pediatrics and Diabetes Research Centre, Faculty of Health Sciences, Linkoping, Sweden
    Pediatr Diabetes 8:34-9. 2007
    ..Future studies will show whether the good effect seen so far can be confirmed. If so there is hope that GAD vaccination will cause remission and even cure and prevention of T1D will then no longer be just a dream...
  18. ncbi request reprint For debate: are we ready for GAD-vaccination in the treatment and/or prevention of type 1 diabetes?
    Johnny Ludvigsson
    Div of Pediatrics and Diabetes Research Centre, Dept of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Pediatr Endocrinol Rev 5:871-2. 2008
  19. ncbi request reprint Treatment with antioxidants at onset of type 1 diabetes in children: a randomized, double-blind placebo-controlled study
    J Ludvigsson
    Division of Pediatrics, Department of Health and Environment, Linkoping University, Linkoping, Sweden
    Diabetes Metab Res Rev 17:131-6. 2001
    ..To evaluate this hypothesis a combination of various antioxidative agents was employed in a double-blind randomized study...
  20. pmc Photopheresis at onset of type 1 diabetes: a randomised, double blind, placebo controlled trial
    J Ludvigsson
    Division of Pediatrics, Department of Health and Environment, Linkoping University, S 581 85 Linkoping, Sweden
    Arch Dis Child 85:149-54. 2001
    ..In recent years photopheresis, an extracorporeal form of photochemotherapy using psoralen and ultraviolet A irradiation of leucocytes, has been claimed to be an effective form of immunomodulation...
  21. doi request reprint GAD-alum (Diamyd)--a new concept for preservation of residual insulin secretion
    Johnny Ludvigsson
    Department of Clinical and Experimental Medicine, Division of Pediatrics and Diabetes Research Center, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Expert Opin Biol Ther 10:787-99. 2010
    ..This review covers a new type of immune intervention using auto-antigen treatment...
  22. doi request reprint Extended evaluation of the safety and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes: a randomised controlled trial
    J Ludvigsson
    Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, SE 58185, Linkoping, Sweden
    Diabetologia 54:634-40. 2011
    ..The aim of this study was to investigate the safety and efficacy of alum formulated glutamic acid decarboxylase GAD(65) (GAD-alum) treatment of children and adolescents with type 1 diabetes after 4 years of follow-up...
  23. pmc The role of immunomodulation therapy in autoimmune diabetes
    Johnny Ludvigsson
    Division of Pediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Linkoping University, Sweden
    J Diabetes Sci Technol 3:320-30. 2009
    ..The prospects of cure and prevention of T1DM will become less remote...
  24. ncbi request reprint Diabetes-related autoantibodies in cord blood from children of healthy mothers have disappeared by the time the child is one year old
    Johnny Ludvigsson
    Division of Pediatrics, Department of Health and Environment, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Ann N Y Acad Sci 958:289-92. 2002
    ..Antibody screening of cord blood cannot be used to predict diabetes in the general population. Infections during pregnancy may initiate an immune process related to diabetes development...
  25. ncbi request reprint Mothers of children in ABIS, a population-based screening for prediabetes, experience few ethical conflicts and have a positive attitude
    Johnny Ludvigsson
    Division of Pediatrics, Department of Health and Environment, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Ann N Y Acad Sci 958:376-81. 2002
    ..We conclude that a well-designed screening program to detect individuals in the general population with high risk of developing diabetes does not evoke anxiety nor severe ethical conflicts...
  26. ncbi request reprint Higher prevalence of autoantibodies to insulin and GAD65 in Swedish compared to Lithuanian children with type 1 diabetes
    Hanna Holmberg
    Department of Molecular and Clinical Medicine, Clinical Research Center, Division of Pediatrics and Diabetes Research Centre, Faculty of Health Sciences, Linkopings Universitet, Sweden
    Diabetes Res Clin Pract 72:308-14. 2006
    ..Furthermore, the disease in patients with insulin autoantibodies seems to be clinically milder...
  27. pmc Exclusive breastfeeding of Swedish children and its possible influence on the development of obesity: a prospective cohort study
    Karina Huus
    Division of Pediatrics, Diabetes Research Centre, Linkoping University, Sweden
    BMC Pediatr 8:42. 2008
    ..The aim of our study was to examine the relationship between exclusive breastfeeding and obesity when potential confounders, such as socioeconomic factors, are considered...
  28. ncbi request reprint Short duration of breast-feeding as a risk-factor for beta-cell autoantibodies in 5-year-old children from the general population
    Hanna Holmberg
    Department of Molecular and Clinical Medicine, Linkopings Universitet, Sweden
    Br J Nutr 97:111-6. 2007
    ....
  29. ncbi request reprint Psychological stress may induce diabetes-related autoimmunity in infancy
    Anneli Sepa
    Division of Paediatrics, Department of Molecular and Clinical Medicine, Linkoping University, SE 581 85 Linkoping, Sweden
    Diabetes Care 28:290-5. 2005
    ..Our aim was to investigate whether psychological stress, measured as psychosocial strain in families, is associated with diabetes-related autoimmunity during infancy...
  30. doi request reprint Good glycemic control remains crucial in prevention of late diabetic complications--the Linköping Diabetes Complications Study
    Maria Nordwall
    Division of Pediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 10:168-76. 2009
    ..The aim of the present study was to analyze possible risk factors, which could explain the improved prognosis...
  31. doi request reprint GAD-alum treatment induces GAD65-specific CD4+CD25highFOXP3+ cells in type 1 diabetic patients
    Maria Hjorth
    Division of Pediatrics and Diabetes Research Center, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Clin Immunol 138:117-26. 2011
    ..These new data suggest that GAD-alum treatment induced GAD(65)-specific T cells with regulatory features...
  32. doi request reprint GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral response
    Mikael Chéramy
    Division of Paediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Linkoping University, Sweden
    Clin Immunol 137:31-40. 2010
    ..In the GAD-alum group, higher pre-treatment GADA were associated to more pronounced C-peptide preservation. The induced IgG3/IgG4 and reduced IgG1 suggest a Th2 deviation of the immune response...
  33. ncbi request reprint Web 2.0 systems supporting childhood chronic disease management: design guidelines based on information behaviour and social learning theories
    Joakim Ekberg
    Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
    J Med Syst 34:107-17. 2010
    ..After integration with the key elements derived from theories of information behaviour, a preliminary design guideline document was formulated...
  34. ncbi request reprint The importance of CTLA-4 polymorphism and human leukocyte antigen genotype for the induction of diabetes-associated cytokine response in healthy school children
    Carl Oscar Jonson
    Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 8:185-92. 2007
    ..Genetic and environmental risk factors precede the onset of T1D, which is characterized by a T helper 1 cell-dominating cytokine response to diabetes-related autoantigens...
  35. ncbi request reprint Probiotics for the prevention of beta cell autoimmunity in children at genetic risk of type 1 diabetes--the PRODIA study
    Martin Ljungberg
    Centre of Clinical Experimental Research, Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
    Ann N Y Acad Sci 1079:360-4. 2006
    ..The prevalence of autoantibodies among the study subjects at 6, 12, and 24 months of age was at levels close to the expected and the clinical follow-up did not either indicate problems in the feasibility of the study...
  36. ncbi request reprint Dietary risk factors for the emergence of type 1 diabetes-related autoantibodies in 21/2 year-old Swedish children
    Jeanette Wahlberg
    Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Br J Nutr 95:603-8. 2006
    ....
  37. ncbi request reprint Decreased in vitro type 1 immune response against coxsackie virus B4 in children with type 1 diabetes
    Susanne Skarsvik
    Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Linkoping University, S 581 85 Linkoping, Sweden
    Diabetes 55:996-1003. 2006
    ..This may lead to a delayed clearance of the virus and, at least partly, explain why children with type 1 diabetes may be more prone to CVB4 infections and related complications, such as beta-cell damage...
  38. doi request reprint Health-related quality of life in intensively treated young patients with type 1 diabetes
    Lena Hanberger
    Diabetes Research Centre, Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 10:374-81. 2009
    ..28, p = 0.045). We conclude that the diabetes team can influence the HRQOL of the patients as there was a centre difference and because HRQOL is influenced by glycaemic control and insulin regimen. Girls seem to need extra support...
  39. ncbi request reprint A1C in children and adolescents with diabetes in relation to certain clinical parameters: the Swedish Childhood Diabetes Registry SWEDIABKIDS
    Lena Hanberger
    Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Diabetes Care 31:927-9. 2008
    ..We explored the relationship between A1C and insulin regimen, duration of diabetes, age, sex, and BMI as well as the differences between clinical mean A1C levels at pediatric diabetes clinics in Sweden...
  40. ncbi request reprint Nicotinamide reduces high secretion of IFN-gamma in high-risk relatives even though it does not prevent type 1 diabetes
    Maria Hedman
    Division of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    J Interferon Cytokine Res 26:207-13. 2006
    ..Nicotinamide caused decreased spontaneous (p = 0.05) and in vitro autoantigen-induced IFN-gamma secretion (p < 0.05) and may play a role in immune regulation, even though it has not been shown to prevent T1D...
  41. pmc Long-lasting immune responses 4 years after GAD-alum treatment in children with type 1 diabetes
    Stina Axelsson
    Division of Paediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    PLoS ONE 6:e29008. 2011
    ..In parallel to a GAD(65)-induced T-cell activation, our results show induction of T-cell inhibitory pathways important for regulating the GAD(65) immunity...
  42. ncbi request reprint Mothers' attachment insecurity and diabetes-related autoantibodies in their infants
    Anneli Sepa
    Division of Pediratrics, Dept of Molecular and Clinical Medicine, Linkoping University, SE 581 85 Linkoping, Sweden
    Ann N Y Acad Sci 1037:110-3. 2004
    ..If an association exists between maternal attachment insecurity and diabetes-related autoimmunity during infancy, it does not appear to be strong...
  43. ncbi request reprint Environmental factors related to the induction of beta-cell autoantibodies in 1-yr-old healthy children
    Jeanette Wahlberg
    Division of Pediatrics and Diabetes Research Center, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 6:199-205. 2005
    ..6), whereas type 2 diabetes in grandparents was associated with GADA (OR 2.1). Exposure to cow's milk formulas <2 months of age implied an OR of 2.9 for IA-2A above the 99th percentile...
  44. ncbi request reprint Diminished IFN-gamma response to diabetes-associated autoantigens in children at diagnosis and during follow up of type 1 diabetes
    Maria Karlsson Faresjo
    Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
    Diabetes Metab Res Rev 22:462-70. 2006
    ..Imbalance of T-helper (Th)1- and Th2-like cytokines has been associated with type 1 diabetes. We therefore studied the immune deviation in antigen-specific T cells from diagnosis onwards in type 1 diabetic children...
  45. ncbi request reprint Early diabetic complications in a population of young patients with type 1 diabetes mellitus despite intensive treatment
    Maria Nordwall
    Division of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, University Hospital, Linkoping, Sweden
    J Pediatr Endocrinol Metab 19:45-54. 2006
    ..To describe the prevalence of early complications in an unselected population of patients with type 1 diabetes mellitus (DM1) diagnosed in childhood with intensive insulin treatment from diagnosis...
  46. doi request reprint Early induction of GAD(65)-reactive Th2 response in type 1 diabetic children treated with alum-formulated GAD(65)
    Stina Axelsson
    Division of Paediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Diabetes Metab Res Rev 26:559-68. 2010
    ....
  47. doi request reprint Psychological stress and obesity
    Felix Sebastian Koch
    Division of Pediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    J Pediatr 153:839-44. 2008
    ..To examine whether there is a relationship between psychological stress in the family and obesity in 5- to 6-year-old children...
  48. ncbi request reprint Mothers' experiences of serious life events increase the risk of diabetes-related autoimmunity in their children
    Anneli Sepa
    Division of Paediatrics, Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, SE 581 85, Linkoping, Sweden
    Diabetes Care 28:2394-9. 2005
    ..e., irrespective of genetic risk for type 1 diabetes) whether mothers' experiences of serious life events, such as divorce and violence, were associated with diabetes-related autoimmunity in their children at age 2.5 years...
  49. ncbi request reprint Clinical manifestations and beta cell function in Swedish diabetic children have remained unchanged during the last 25 years
    Maria Nordwall
    Division of Paediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linkoping University, Linkoping, Sweden
    Diabetes Metab Res Rev 24:472-9. 2008
    ..The aim of this study was to examine the clinical characteristics at onset, C-peptide secretion during the first years after diagnosis and if there was any secular trends during the last 25 years...
  50. ncbi request reprint Hypoglycemia and ketoacidosis with insulin pump therapy in children and adolescents
    Ragnar Hanas
    Department of Pediatrics, Uddevalla Hospital, Uddevalla, Sweden
    Pediatr Diabetes 7:32-8. 2006
    ..Increased teaching and awareness programs are vital to prevent severe hypoglycemia and DKA in children and adolescents using insulin pumps...
  51. doi request reprint Tobacco exposure and diabetes-related autoantibodies in children: results from the ABIS study
    AnnaKarin Johansson
    Department of Clinical and Experimental Medicine, Division of Pediatrics, Faculty of Health Sciences, Diabetes Research Center, Linkoping University, Linkoping, Sweden
    Ann N Y Acad Sci 1150:197-9. 2008
    ..It was concluded that passive smoking does not seem to influence development of diabetes-related autoantibodies early in life...
  52. ncbi request reprint Progression to type 1 diabetes and autoantibody positivity in relation to HLA-risk genotypes in children participating in the ABIS study
    Camilla Gullstrand
    Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 9:182-90. 2008
    ..In this study, we have investigated the role of HLA-risk and -protective genotypes for development of beta-cell autoantibodies and progression to T1D in healthy children...
  53. pmc High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus
    Johan F Paulsson
    Department of Clinical and Experimental Medicine, Division of Pediatrics and Diabetes Research Centre, Linkoping University Hospital, Linkoping, Sweden
    PLoS ONE 9:e93053. 2014
    ..Even though IAPP and amyloid formation are much discussed in type 2 diabetes, our aim was to study the significance of IAPP in type 1 diabetes...
  54. ncbi request reprint When should determination of ketonemia be recommended?
    Ulf Samuelsson
    Division of Pediatrics, Department of Health and Environment, Linkoping University, Linkoping, Sweden
    Diabetes Technol Ther 4:645-50. 2002
    ..Monitoring beta-OHB should be routine for patients on pump therapy...
  55. doi request reprint Maternal influence on child HPA axis: a prospective study of cortisol levels in hair
    Jerker Karlén
    Division of Community Medicine, Department of Medicine and Health Sciences, Linkoping University, SE 581 83 Linkoping, Sweden
    Pediatrics 132:e1333-40. 2013
    ..To investigate cortisol concentrations in hair as biomarker of prolonged stress in young children and their mothers and the relation to perinatal and sociodemographic factors...
  56. ncbi request reprint Information and informed consent in a longitudinal screening involving children: a questionnaire survey
    Ulrica Gustafsson Stolt
    Department of Molecular and Clinical Medicine, Division of Paediatrics, Faculty of Health Sciences, SE 581 85 Linkoping, Sweden
    Eur J Hum Genet 13:376-83. 2005
    ....
  57. pmc GAD autoantibody epitope pattern after GAD-alum treatment in children and adolescents with type 1 diabetes
    Camilla Skoglund
    Division of Pediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 13:244-50. 2012
    ..The aim of this study was to investigate whether GAD-alum treatment affected the GADA epitope pattern...
  58. pmc Adaptive and innate immune responsiveness to Borrelia burgdorferi sensu lato in exposed asymptomatic children and children with previous clinical Lyme borreliosis
    Barbro H Skogman
    Department of Pediatrics, Falun General Hospital, Sweden
    Clin Dev Immunol 2012:294587. 2012
    ..Thus, the immunological mechanisms of importance for eradicating the spirochete effectively without developing clinical manifestations of LB remain unknown...
  59. doi request reprint The effect of gluten-free diet on Th1-Th2-Th3-associated intestinal immune responses in celiac disease
    Anne Lahdenperä
    Division of Paediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Scand J Gastroenterol 46:538-49. 2011
    ....
  60. ncbi request reprint Parents' attitudes to children's tobacco smoke exposure and how the issue is handled in health care
    AnnaKarin Johansson
    Division of Paediatrics, Department of Molecular and Clinical Medicine, Linkoping University, Linkoping, Sweden
    J Pediatr Health Care 18:228-35. 2004
    ....
  61. doi request reprint Low C-peptide levels and decreased expression of TNF and CD45 in children with high risk of type 1 diabetes
    Linda Akerman
    Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Clin Immunol 148:4-15. 2013
    ..Hence, expression of immune related genes seemed related not only to the autoimmune process but rather to residual β-cell function, which was decreased already during the pre-diabetic phase...
  62. ncbi request reprint Indwelling catheters used from the onset of diabetes decrease injection pain and pre-injection anxiety
    Ragnar Hanas
    Department of Pediatrics, Uddevalla Hospital, Uddevalla, Sweden
    J Pediatr 140:315-20. 2002
    ..To investigate the use of indwelling catheters as injection aids at diabetes onset to reduce injection pain and pre-injection anxiety...
  63. doi request reprint Could the social environment trigger the induction of diabetes related autoantibodies in young children?
    Jerker Karlén
    Department of Medical and Health Sciences Community Medicine, Linkoping University, Sweden
    Scand J Public Health 40:177-82. 2012
    ..We have implemented a study design where 1-year-old children, from two equally sized, neighbouring but socioeconomically different cities, were compared for the induction of beta-cell autoantibodies...
  64. ncbi request reprint Assessment of smoking behaviors in the home and their influence on children's passive smoking: development of a questionnaire
    AnnaKarin Johansson
    Division of Pediatrics, Department of Molecular and Clinical Medicine, Linkoping University, SE 58183 Linkoping, Sweden
    Ann Epidemiol 15:453-9. 2005
    ..To construct and validate a questionnaire aiming to measure children's exposure to environmental tobacco smoke (ETS) in the home...
  65. ncbi request reprint Risk factors in childhood obesity-findings from the All Babies In Southeast Sweden (ABIS) cohort
    Karina Huus
    Division of Pediatrics and Diabetes Research Centre, Linkoping University, Sweden
    Acta Paediatr 96:1321-5. 2007
    ....
  66. doi request reprint Immune intervention in children with type 1 diabetes
    Johnny Ludvigsson
    Department of Clinical and Experimental Medicine, Division of Pediatrics, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Curr Diab Rep 10:370-9. 2010
    ..Combination of immune intervention, protection of the beta cells, and stimulation of regeneration may lead to a milder disease or even a cure in the future, and prevention is no longer unrealistic...
  67. doi request reprint Cryopreserved peripheral blood mononuclear cells are suitable for the assessment of immunological markers in type 1 diabetic children
    Stina Axelsson
    Division of Paediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
    Cryobiology 57:201-8. 2008
    ..Thus, cryopreserved PBMC were suitable to assess the immunological markers included in this study, even though their expression could differ from freshly handled cells...
  68. ncbi request reprint An indirect competitive immunoassay for insulin autoantibodies based on surface plasmon resonance
    Jenny Carlsson
    Division of Sensor Science and Molecular Physics, Department of Physics, Chemistry and Biology IFM, Linkoping University, SE 581 83 Linkoping, Sweden
    Biosens Bioelectron 24:882-7. 2008
    ..With our SPR-based immunoassay the overall assay time is reduced by a factor of >100 (4 days to 50min), while sensitivity is maintained at a level comparable to that offered by RIA...
  69. ncbi request reprint Induction of diabetes-related autoantibodies below cutoff for "positivity" in young nondiabetic children
    Hanna Holmberg
    Department of Molecular and Clinical Medicine, Division of Pediatrics, Clinical Research Center, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Ann N Y Acad Sci 1005:269-74. 2003
    ..We conclude that there is a natural induction of humoral immune response to beta cell autoantigens early in life. Our results suggest that the mechanisms of beta cell tolerance to GAD and IA-2 differ in healthy children...
  70. ncbi request reprint Quality of care from the patient's perspective in pediatric diabetes care
    Lena Hanberger
    Diabetes Research Centre, Division of Pediatrics, IMK, Faculty of Health Sciences, S 581 85 Linkoping, Sweden
    Diabetes Res Clin Pract 72:197-205. 2006
    ..In our setting, improvements are needed regarding patient information, access to care and waiting time...
  71. ncbi request reprint Prevalence of retinopathy differs with age at onset of diabetes in a population of patients with Type 1 diabetes
    C E Kullberg
    Divisions of Ophthalmology, Internal Medicine, and Paediatrics, Faculty of Health Sciences, University Hospital, Linkoping, Sweden
    Diabet Med 19:924-31. 2002
    ....
  72. ncbi request reprint Unchanged incidence of severe retinopathy in a population of Type 1 diabetic patients with marked reduction of nephropathy
    M Bojestig
    Department of Internal Medicine, University Hospital, Linkoping, Sweden
    Diabet Med 15:863-9. 1998
    ..2%; p < 0.008) but there was no difference in the risk of nephropathy. No patients with good control developed nephropathy and only one patient developed severe retinopathy during 25 years of diabetes...
  73. ncbi request reprint The Särimner diabetes simulator--a look in the rear view mirror
    J Hedbrant
    Department of Management and Engineering, Linkoping University, Linkoping, Sweden
    Diabetes Technol Ther 9:10-6. 2007
    ..The aim of this paper is to discuss experiences from the previous work with teenagers on the Särimner diabetes simulator...
  74. ncbi request reprint Continuous monitoring of the subcutaneous glucose level in freely moving normal and diabetic rats and in humans with type 1 diabetes
    Reza Jamali
    Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Diabetes Technol Ther 4:305-12. 2002
    ..We conclude that the Medtronic MiniMed continuous glucose monitoring system can be used to record the subcutaneous glucose level over time in freely moving rats...
  75. ncbi request reprint Fear and other disturbances of severe hypoglycaemia in children and adolescents with type 1 diabetes mellitus
    Sam Nordfeldt
    Center for Medical Technology Assessment, Department of Health and Society, Linkoping University, Linkoping, Sweden
    J Pediatr Endocrinol Metab 18:83-91. 2005
    ..To study perceived occurrence and magnitude of fear and other disturbances of severe hypoglycaemia in children and adolescents with type 1 diabetes mellitus (DM) receiving intensive treatment with active education and psychosocial support...
  76. doi request reprint Relationship of food frequencies as reported by parents to overweight and obesity at 5 years
    Karina Huus
    Department of Clinical and Experimental Medicine, Division of Paediatrics and Diabetes Research Centre, Faculty of Health Sciences, Linkoping University, Sweden
    Acta Paediatr 98:139-43. 2009
    ..To investigate if food frequencies are related to overweight/obesity in 5-year-old children...
  77. ncbi request reprint Adverse health effects related to tobacco smoke exposure in a cohort of three-year olds
    AnnaKarin Johansson
    Department of Medicine and Health Sciences, Division of Nursing Science, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Paediatr 97:354-7. 2008
    ..To analyse the importance of mothers' smoking during pregnancy and/or environmental tobacco smoke (ETS) exposure in early childhood for children's health and well-being at the age of 3 years...
  78. ncbi request reprint The immunological effect of photopheresis in children with newly diagnosed type 1 diabetes
    Maria Karlsson Faresjo
    Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
    Pediatr Res 58:459-66. 2005
    ..Photopheresis has an immune-modulating effect in children with type 1 diabetes, causing a Th2-like deviation...
  79. doi request reprint Detection of global glycosylation changes of serum proteins in type 1 diabetes using a lectin panel and multivariate data analysis
    Jenny Carlsson
    Division of Sensor Science and Molecular Physics, Department of Physics, Chemistry and Biology IFM, Linkoping University, SE 581 83 Linkoping, Sweden
    Talanta 76:333-7. 2008
    ..Using an artificial neuronal net (ANN), it was possible to correctly categorize unknown serum samples into one of the three groups...
  80. doi request reprint Low zinc in drinking water is associated with the risk of type 1 diabetes in children
    Ulf Samuelsson
    Division of Paediatrics, Department of Molecular and Clinical Medicine, Linkoping University, Linkoping, Sweden
    Pediatr Diabetes 12:156-64. 2011
    ..To explore if drinking water may influence the development of type 1 diabetes in children, either via enterovirus spread via drinking water or quality of drinking water related to acidity or concentration of certain minerals...
  81. ncbi request reprint Celiac disease and risk of subsequent type 1 diabetes: a general population cohort study of children and adolescents
    Jonas F Ludvigsson
    Department of Pediatrics, Orebro University Hospital, Orebro 701 85, Sweden
    Diabetes Care 29:2483-8. 2006
    ..We sought to determine the risk of subsequent type 1 diabetes diagnosed before the age of 20 years in children and adolescents with celiac disease in a national, general population-based cohort...
  82. ncbi request reprint Increased prevalence of malignant diseases in the close neighborhood of children with cancer
    Ulf Samuelsson
    Division of Pediatrics, Department of Health and Environment, Linkoping University, S 581 85 Linkoping, Sweden
    J Environ Health 64:18-22. 2002
    ..These results support the hypothesis that environmental factors can initiate or precipitate cancer in children as well as in adults...
  83. ncbi request reprint Development of a PC-based diabetes simulator in collaboration with teenagers with type 1 diabetes
    S Nordfeldt
    Diabetes Research Centre, Division of Pediatrics, Department of Molecular and Clinical Medicine, Linkoping University, Linkoping, Sweden
    Diabetes Technol Ther 9:17-25. 2007
    ..A second aim was to gain experience in user-centered design (UCD) methods applied to such subjects...
  84. ncbi request reprint A fourfold difference in the incidence of type 1 diabetes between Sweden and Lithuania but similar prevalence of autoimmunity
    U Samuelsson
    Division of Paediatrics, Department of Health and Environment, Linkoping University, Linköping S 581 85, Sweden
    Diabetes Res Clin Pract 66:173-81. 2004
    ..5%, respectively, P < 0.001) (OR = 3.21). There seem to be environmental factors that specifically contribute to the development of type 1 diabetes, factors which are less related to the development of autoimmunity in general...
  85. pmc Regulatory T cell-associated activity in photopheresis-induced immune tolerance in recent onset type 1 diabetes children
    C O Jonson
    Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Clin Exp Immunol 153:174-81. 2008
    ..These parameters were counteracted by ECP. In conclusion, our results indicate that ECP maintains regulatory T cell-associated activity in recent-onset T1D...
  86. doi request reprint Antibody response to insulin in children and adolescents with newly diagnosed Type 1 diabetes
    H Holmberg
    Division of Paediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Diabet Med 25:792-7. 2008
    ....
  87. ncbi request reprint Seasonal variation of birth month and breastfeeding in children with diabetes mellitus
    U Samuelsson
    Department of Health and Environment, Linkoping University, Sweden
    J Pediatr Endocrinol Metab 14:43-6. 2001
    ....
  88. ncbi request reprint The concentrations of short-chain fatty acids and other microflora-associated characteristics in faeces from children with newly diagnosed Type 1 diabetes and control children and their family members
    U Samuelsson
    Division of Paediatrics, Department of Molecular and Clinical Medicine, Linkoping University, Linkoping, Sweden
    Diabet Med 21:64-7. 2004
    ....
  89. ncbi request reprint Islet autoantibodies in the prediction of diabetes in school children
    U Samuelsson
    Department of Health and Environment, Division of Pediatrics, Linkoping University, S 581 85, Linkoping, Sweden
    Diabetes Res Clin Pract 51:51-7. 2001
    ..Thus, GADA and ICA measurements may be a rational approach to detect schoolchildren at risk for developing diabetes...
  90. ncbi request reprint Intensive insulin treatment in diabetic children
    J Ludvigsson
    Department of Health and Environment, , Sweden
    Diabetes Nutr Metab 14:292-304. 2001
    ..Thus, appropriate education should be delivered at diabetes onset to the child and parents in order to start the strategy of intensified insulin therapy as early as possible...
  91. ncbi request reprint Determination of mRNA expression for IFN-gamma and IL-4 in lymphocytes from children with IDDM by RT-PCR technique
    M G Karlsson
    Department of Health and Environment, Faculty of Health Sciences, University Hospital, Linkoping, Sweden
    Diabetes Res Clin Pract 40:21-30. 1998
    ..Further studies are needed to confirm whether increased IFN-gamma mRNA in Th1-like lymphocytes stimulated with this specific GAD-peptide play a role in the cell-mediated immune response seen in children early after the onset of IDDM...
  92. ncbi request reprint Cytokine profile in children during the first 3 months after the diagnosis of type 1 diabetes
    M G E Karlsson Faresjö
    Division of Pediatrics and Diabetic Research Centre, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Scand J Immunol 59:517-26. 2004
    ..05), even though cytokine secretion remained low. Thus, duration after diagnosis as well as metabolic state should be carefully considered both in studies of the pathogenesis of type 1 diabetes and in immune intervention studies at onset...
  93. ncbi request reprint Declining incidence of severe retinopathy and persisting decrease of nephropathy in an unselected population of Type 1 diabetes-the Linköping Diabetes Complications Study
    M Nordwall
    Division of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, University Hospital, Linkoping, Sweden
    Diabetologia 47:1266-72. 2004
    ..The aim of our current study was to investigate the incidence 5 to 10 years later in the same population...
  94. ncbi request reprint Could parenting stress and lack of support/confidence function as mediating mechanisms between certain environmental factors and the development of autoimmunity in children?: a study within ABIS
    Anneli Sepa
    Division of Pediatrics, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, University of Linkoping, Linkoping, Sweden
    Ann N Y Acad Sci 958:431-5. 2002
    ..These results support the hypothesis of psychological mechanisms as mediating variables between a number of disparate risk factors and the development of type 1 diabetes...
  95. ncbi request reprint Nurses' views of longitudinal genetic screening of and research on children
    Ulrica Gustafsson Stolt
    Faculty of Health Sciences, Linkoping University, Sweden
    Br J Nurs 14:71-7. 2005
    ..It is also suggested that the design of the information process, and especially in longitudinal research involving young children, is of utmost importance before such studies are commenced...
  96. ncbi request reprint Diminished Th1-like response to autoantigens in children with a high risk of developing type 1 diabetes
    M G E Karlsson Faresjö
    Division of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Scand J Immunol 61:173-9. 2005
    ..Thus, a diminished Th1-like response by in vitro autoantigen stimulation was observed in especially children with a high risk of developing type 1 diabetes. Reduced Th1/Th2 response was related to signs of beta cell exhaustion...
  97. ncbi request reprint Unchanged insulin absorption after 4 days' use of subcutaneous indwelling catheters for insulin injections
    S R Hanas
    Department of Pediatrics, Uddevalla Hospital, Sweden
    Diabetes Care 20:487-90. 1997
    ..However, some patients experience a rise in blood glucose after using indwelling catheters for a few days. We therefore studied the absorption of 125I-labeled insulin when using indwelling catheters...
  98. ncbi request reprint Seasonal variation of HbA1c in intensive treatment of children with type 1 diabetes
    S Nordfeldt
    Division of Child and Adolescent Psychiatry, Faculty of Health Sciences, Linkoping, Sweden
    J Pediatr Endocrinol Metab 13:529-35. 2000
    ....
  99. ncbi request reprint How should parents protect their children from environmental tobacco-smoke exposure in the home?
    AnnaKarin Johansson
    Division of Paediatrics, Department of Molecular and Clinical Medicine, Linkoping University, Linkoping, Sweden
    Pediatrics 113:e291-5. 2004
    ..Children's exposure to tobacco smoke is known to have adverse health effects, and most parents try to protect their children...
  100. doi request reprint Parent perceptions of child sleep: a study of 10,000 Swedish children
    Peder Palmstierna
    Department of Clinical and Experimental Medicine, Diabetes Research Centre, Linkoping University, Linkoping, Sweden
    Acta Paediatr 97:1631-9. 2008
    ..To gather normative data on parent-reported child sleep and investigate what influences it...
  101. pmc Aberrant regulation of interleukin-12 receptor beta2 chain on type 1 cytokine-stimulated T lymphocytes in type 1 diabetes
    Susanne Skarsvik
    Division of Pediatrics, Department of Molecular and Clinical Medicine, Clinical Research Centre, Linkoping University, Linkoping, Sweden
    Immunology 114:287-93. 2005
    ..006 and P=0.04) in a type 1 cytokine environment was seen in both groups of patients. Peripheral blood T cells from patients with both newly diagnosed and longstanding T1D showed poor polarization towards type 1 cells...