Anders Larsson

Summary

Affiliation: University Hospital
Country: Sweden

Publications

  1. ncbi Serum and plasma levels of FGF-2 and VEGF in healthy blood donors
    A Larsson
    Department of Clinical Chemistry and Pharmacology, University Hospital, Uppsala, Sweden
    Angiogenesis 5:107-10. 2002
  2. ncbi Comparison between chicken and rabbit antibody based particle enhanced cystatin C reagents for immunoturbidimetry
    Lars Olof Hansson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    J Immunoassay Immunochem 29:1-9. 2008
  3. ncbi [Analysis of beta-"trace" protein detects leakage of cerebrospinal fluid. Quickly, safely and cheaply]
    Anders Larsson
    Akademiska laboratoriet, Klinisk kemi och farmakologi, Akademiska sjukhuset, Uppsala
    Lakartidningen 100:943-5. 2003
  4. ncbi Oral immunotherapy with yolk antibodies to prevent infections in humans and animals
    Anders Larsson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Ups J Med Sci 108:129-40. 2003
  5. ncbi High sensitivity CRP and serum amyloid A as expressions of low grade inflammation do not correlate with bFGF or VEGF
    A Larsson
    Department of Clinical Chemistry and Pharmacology, University Hospital, Uppsala, Sweden
    Ups J Med Sci 108:51-9. 2003
  6. ncbi Calculation of glomerular filtration rate expressed in mL/min from plasma cystatin C values in mg/L
    A Larsson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Scand J Clin Lab Invest 64:25-30. 2004
  7. ncbi [Modest clinical benefits of ASAT analysis in today's health care. A case report of macro-ASAT giving rise to pathologically increased ASAT levels]
    Anders Larsson
    Avdelningen för klinisk kemi och farmakologi, Akademiska sjukhuset, Uppsala
    Lakartidningen 99:3695-6. 2002
  8. ncbi Studies of fibrinogen binding to porcine platelets by flow cytometry: a method for studies of porcine platelet activation
    Anders Larsson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Platelets 13:153-7. 2002
  9. pmc Serum FGF23 and risk of cardiovascular events in relation to mineral metabolism and cardiovascular pathology
    Johan Arnlov
    Department of Public Health and Caring Sciences Section of Geriatrics, Uppsala University, Uppsala, Sweden
    Clin J Am Soc Nephrol 8:781-6. 2013
  10. pmc Inflammation, oxidative stress, glomerular filtration rate, and albuminuria in elderly men: a cross-sectional study
    Elisabet Nerpin
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, SE 751 85, Uppsala, Sweden
    BMC Res Notes 5:537. 2012

Detail Information

Publications116 found, 100 shown here

  1. ncbi Serum and plasma levels of FGF-2 and VEGF in healthy blood donors
    A Larsson
    Department of Clinical Chemistry and Pharmacology, University Hospital, Uppsala, Sweden
    Angiogenesis 5:107-10. 2002
    ..Separate gender based reference intervals were made for S-FGF-2 as women had significantly higher S-FGF-2 values. Reference values for S-FGF-2 were <4.0 ng/l (men) and <10.8 ng/l (women)...
  2. ncbi Comparison between chicken and rabbit antibody based particle enhanced cystatin C reagents for immunoturbidimetry
    Lars Olof Hansson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    J Immunoassay Immunochem 29:1-9. 2008
    ..The reagent also showed a low CV for duplicate samples. Laying hens thus seems as an interesting source of antibodies for particle-enhanced immunoassays...
  3. ncbi [Analysis of beta-"trace" protein detects leakage of cerebrospinal fluid. Quickly, safely and cheaply]
    Anders Larsson
    Akademiska laboratoriet, Klinisk kemi och farmakologi, Akademiska sjukhuset, Uppsala
    Lakartidningen 100:943-5. 2003
    ..Analysis of beta-trace protein via a nephelometric assay is a valuable test for the identification of cerebrospinal fluid in rhinorrhea or otorrhea...
  4. ncbi Oral immunotherapy with yolk antibodies to prevent infections in humans and animals
    Anders Larsson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Ups J Med Sci 108:129-40. 2003
    ..We have treated one patient with yolk antibodies against P. aeruginosa daily for more than eight years, which shows that it is possible to use yolk immunotherapy over long treatment periods...
  5. ncbi High sensitivity CRP and serum amyloid A as expressions of low grade inflammation do not correlate with bFGF or VEGF
    A Larsson
    Department of Clinical Chemistry and Pharmacology, University Hospital, Uppsala, Sweden
    Ups J Med Sci 108:51-9. 2003
    ..There were strong correlations between hsCRP and SAA but there were no significant correlation between hsCRP or SAA and any of the angiogenic peptides. Low-grade inflammation did not induce bFGF or VEGF production...
  6. ncbi Calculation of glomerular filtration rate expressed in mL/min from plasma cystatin C values in mg/L
    A Larsson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Scand J Clin Lab Invest 64:25-30. 2004
    ..These formulas can provide the clinicians with reliable and readily available GFR data based on single measurements of cystatin C concentrations...
  7. ncbi [Modest clinical benefits of ASAT analysis in today's health care. A case report of macro-ASAT giving rise to pathologically increased ASAT levels]
    Anders Larsson
    Avdelningen för klinisk kemi och farmakologi, Akademiska sjukhuset, Uppsala
    Lakartidningen 99:3695-6. 2002
    ..So far, macro-AST has only been described in a few patients. Here, we report a case of macro-AST in a healthy female. Clinicians should be aware of this phenomenon so that patients are not subjected to unnecessary investigations...
  8. ncbi Studies of fibrinogen binding to porcine platelets by flow cytometry: a method for studies of porcine platelet activation
    Anders Larsson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Platelets 13:153-7. 2002
    ..ADP, ristocetin and thrombin induce fibrinogen binding to porcine platelets similarly to human platelets. Ristocetin induces platelet aggregation and microvesicle formation from porcine platelets as well as from human platelets...
  9. pmc Serum FGF23 and risk of cardiovascular events in relation to mineral metabolism and cardiovascular pathology
    Johan Arnlov
    Department of Public Health and Caring Sciences Section of Geriatrics, Uppsala University, Uppsala, Sweden
    Clin J Am Soc Nephrol 8:781-6. 2013
    ..This study tested whether this association is independent of mineral metabolism and indices of subclinical cardiovascular pathology...
  10. pmc Inflammation, oxidative stress, glomerular filtration rate, and albuminuria in elderly men: a cross-sectional study
    Elisabet Nerpin
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, SE 751 85, Uppsala, Sweden
    BMC Res Notes 5:537. 2012
    ....
  11. doi Higher cathepsin B levels in plasma in Alzheimer's disease compared to healthy controls
    Johan Sundelöf
    Uppsala University, Department of Public Health Geriatrics, Uppsala, Sweden
    J Alzheimers Dis 22:1223-30. 2010
    ..Further investigation of cathepsin B as a predictor of AD is warranted...
  12. doi Cystatin C and modification of diet in renal disease (MDRD) estimated glomerular filtration rate differ during normal pregnancy
    Anders Larsson
    Department of Medical Sciences, Clinical Chemistry, Uppsala, Sweden
    Acta Obstet Gynecol Scand 89:939-44. 2010
    ..Plasma creatinine and cystatin C are the two most widely used GFR markers. Both markers are recommended to be automatically reported as estimated GFR...
  13. doi Use of multiple biomarkers to improve the prediction of death from cardiovascular causes
    Bjorn Zethelius
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    N Engl J Med 358:2107-16. 2008
    ..The incremental usefulness of adding multiple biomarkers from different disease pathways for predicting the risk of death from cardiovascular causes has not, to our knowledge, been evaluated among the elderly...
  14. doi The time course of body temperature, serum amyloid A protein, C-reactive protein and interleukin-6 in patients with bacterial infection during the initial 3 days of antibiotic therapy
    Anders Lannergård
    Department of Medical Sciences, Section of Infectious Diseases, University Hospital, Uppsala, Sweden
    Scand J Infect Dis 41:663-71. 2009
    ..Further studies are proposed for biomarker guidance antibiotic therapy in sepsis patients without septic shock...
  15. doi Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population
    Majd A I Mirza
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Atherosclerosis 207:546-51. 2009
    ..Additional longitudinal studies that evaluate the predictive power of FGF23 and whether FGF23 has additional clinical applications are needed...
  16. doi The combined contribution of albuminuria and glomerular filtration rate to the prediction of cardiovascular mortality in elderly men
    Elisabet Nerpin
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    Nephrol Dial Transplant 26:2820-7. 2011
    ..Yet, data on whether the combined addition of albuminuria and estimated glomerular filtration rate (eGFR) improves cardiovascular risk prediction in individuals without CVD in the community is scarce...
  17. doi Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia: a prospective population-based study
    Johan Sundelöf
    Department of Public Health and Caring Sciences Geriatrics, Faculty of Medicine, Uppsala University, Uppsala, Sweden
    J Alzheimers Dis 18:71-8. 2009
    ..In conclusion, systemic serum alpha- and gamma-tocopherol and urinary F2-isoprostane levels are not associated with the future risk of AD or dementia and do not seem to be useful predictors of clinical AD or dementia...
  18. doi Urinary neutrophil gelatinase-associated lipocalin (NGAL) is associated with mortality in a community-based cohort of older Swedish men
    Johanna Helmersson-Karlqvist
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Atherosclerosis 227:408-13. 2013
    ....
  19. pmc Serum cathepsin S is associated with decreased insulin sensitivity and the development of type 2 diabetes in a community-based cohort of elderly men
    Elisabeth Jobs
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden
    Diabetes Care 36:163-5. 2013
    ..To investigate associations between serum cathepsin S, impaired insulin sensitivity, defective insulin secretion, and diabetes risk in a community-based sample of elderly men without diabetes...
  20. doi Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community
    Johan Arnlov
    Department of Public Health and Caring Sciences Section of Geriatrics Uppsala University, Uppsala, Sweden
    Kidney Int 83:160-6. 2013
    ..Thus, a higher FGF23 level is associated with an increased cardiovascular mortality risk in the community. Clinical trials are needed to determine whether FGF23 is a modifiable risk factor...
  21. ncbi Serum selenium predicts levels of F2-isoprostanes and prostaglandin F2alpha in a 27 year follow-up study of Swedish men
    Johanna Helmersson
    Clinical Nutrition Research Geriatrics, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden
    Free Radic Res 39:763-70. 2005
    ..The associations between Se, oxidative stress and inflammation, respectively, might be related to the proposed cardiovascular protective property of Se...
  22. doi Systemic inflammation and the risk of Alzheimer's disease and dementia: a prospective population-based study
    Johan Sundelöf
    Department of Public Health and Caring Sciences Geriatrics, Faculty of Medicine, Uppsala University, Uppsala, Sweden
    J Alzheimers Dis 18:79-87. 2009
    ..In conclusion, Serum IL-6, hsCRP, SAA, and PGF2alpha levels are not associated with the risk of AD. High serum IL-6 levels may be associated with increased risk of non-AD dementia...
  23. ncbi More than 10 years' continuous oral treatment with specific immunoglobulin Y for the prevention of Pseudomonas aeruginosa infections: a case report
    Elin Nilsson
    Clinical Chemistry, Department of Medical Sciences, University Hospital, Uppsala, Sweden
    J Med Food 10:375-8. 2007
    ..No negative side effects of IgY treatment have been noted during these 10 years. To our knowledge this is the longest treatment with specific yolk antibodies for therapeutic purposes...
  24. doi Artery wall layer dimensions during normal pregnancy: a longitudinal study using noninvasive high-frequency ultrasound
    Tansim Akhter
    Department of Women s and Children s Health, Section for Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden
    Am J Physiol Heart Circ Physiol 304:H229-34. 2013
    ..A less likely explanation involves possible adaptation to physiological changes during and after pregnancy...
  25. doi A longitudinal study of plasma levels of soluble fms-like tyrosine kinase 1 (sFlt1), placental growth factor (PlGF), sFlt1: PlGF ratio and vascular endothelial growth factor (VEGF-A) in normal pregnancy
    Maria Palm
    Department of Women s and Children s Health, Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden
    Acta Obstet Gynecol Scand 90:1244-51. 2011
    ..To describe plasma levels of angiogenic (PlGF, VEGF-A) and anti-angiogenic (sFlt1) factors as well as the sFlt1:PlGF ratio throughout normal pregnancy and postpartum...
  26. ncbi Steroids reduce local inflammatory mediator secretion and mucosal permeability in collagenous colitis patients
    Yesuf Taha
    Departments of Medical Sciences, University Hospital, Uppsala, Sweden
    World J Gastroenterol 12:7012-8. 2006
    ....
  27. ncbi Effects on blood compatibility in vitro by combining a direct P2Y12 receptor inhibitor and heparin coating of stents
    Kjeld Christensen
    Division of Cardiology, University Hospital, Orebro, Sweden
    Platelets 17:318-27. 2006
    ..The conclusion is that the direct P2Y12 receptor inhibitor AR-C69931MX reduced the different aspects of activation of blood induced by both unmodified and heparin-coated stents...
  28. ncbi Angiopoietin-1/angiopoietin-2 ratio for prediction of preeclampsia
    Marie Bolin
    Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden
    Am J Hypertens 22:891-5. 2009
    ..The purpose of this prospective, longitudinal cohort study was to determine whether a ratio between Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) can be used to predict preeclampsia in a low-risk population...
  29. doi Effect of a single dose of tobramycin on systemic inflammatory response-induced acute kidney injury in a 6-hour porcine model
    Miklos Lipcsey
    Section of Anesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Crit Care Med 37:2782-90. 2009
    ..However, aminoglycosides have nephrotoxic effects that may aggravate sepsis-induced acute kidney injury...
  30. doi Patient selection has a strong impact on cystatin C and Modification of Diet in Renal Disease (MDRD) estimated glomerular filtration rate
    Anders Larsson
    Department of Clinical Chemistry and Pharmacology, University Hospital, Uppsala, Sweden
    Clin Biochem 41:1355-61. 2008
    ..As both cystatin C and creatinine are used for the determination of GFR it is important to investigate if estimated GFR by the two methods differ in various patient groups...
  31. ncbi Low-grade albuminuria and the incidence of heart failure in a community-based cohort of elderly men
    Erik Ingelsson
    Section of Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, Uppsala, Sweden
    Eur Heart J 28:1739-45. 2007
    ..To investigate associations of urinary albumin excretion rate (UAER) and heart failure (HF) incidence in a community-based sample...
  32. ncbi Vascular endothelial growth factor (VEGF)--a possible mediator of inflammation and mucosal permeability in patients with collagenous colitis
    Yesuf Taha
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    Dig Dis Sci 49:109-15. 2004
    ..Patients with collagenous colitis have increased colorectal mucosal secretion of VEGF, which may lead to albumin leakage and promote fibrosis with deposition of collagen...
  33. doi Circadian variability of cystatin C, creatinine, and glomerular filtration rate (GFR) in healthy men during normal sleep and after an acute shift of sleep
    Anders Larsson
    Section of Clinical Chemistry, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Chronobiol Int 25:1047-61. 2008
    ..Small but significant increases in creatinine values and a decrease of eGFR(MDRD) were observed after food intake. Thus, cystatin C and creatinine sampling does not have to be restricted to specific times of the day...
  34. ncbi Inflammatory, coagulatory and circulatory responses to logarithmic increases in the endotoxin dose in the anaesthetised pig
    Miklos Lipcsey
    Section of Anaesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    J Endotoxin Res 12:99-112. 2006
    ....
  35. doi Association between serum cathepsin S and mortality in older adults
    Elisabeth Jobs
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden
    JAMA 306:1113-21. 2011
    ..However, prospective data concerning a potential association between circulating cathepsin S levels and mortality are lacking...
  36. ncbi Effect of the administration rate on the biological responses to a fixed dose of endotoxin in the anesthetized pig
    Miklos Lipcsey
    Section of Anesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Shock 29:173-80. 2008
    ..The biological responses of inflammation, hypotension, hypoperfusion, and organ dysfunction are increased if the organism is exposed to a fixed amount of endotoxin more quickly...
  37. ncbi The role of cystatin C and the angiogenic cytokines VEGF and bFGF in patients with esophageal carcinoma
    Martin Dreilich
    Department of Oncology, University Hospital, Uppsala, Sweden
    Med Oncol 22:29-38. 2005
    ..Results of the present study indicate that use of the angiogenic factors as prognostic factors, prior to therapy in patients with esophageal carcinoma, appears limited...
  38. doi Reference values for alpha1-acid glycoprotein, alpha1-antitrypsin, albumin, haptoglobin, C-reactive protein, IgA, IgG and IgM during pregnancy
    Anders Larsson
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Acta Obstet Gynecol Scand 87:1084-8. 2008
    ..A laboratory test result from a pregnant woman should be compared with pregnancy-specific reference intervals...
  39. doi Early postpartum changes in circulating pro- and anti-angiogenic factors in early-onset and late-onset pre-eclampsia
    Anna Karin Wikström
    Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden
    Acta Obstet Gynecol Scand 87:146-53. 2008
    ..However, there is insufficient knowledge about how these concentrations change after delivery, and whether the changes differ between early-onset and late-onset pre-eclampsia...
  40. doi Serum endostatin and risk of mortality in the elderly: findings from 2 community-based cohorts
    Johan Arnlov
    From the Department of Public Health and Caring Sciences Section of Geriatrics J Ä, Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden E I, J Ä Department of Medical Sciences, Uppsala University, Uppsala, Sweden A L, J S, L L School of Health and Social Studies, Dalarna University, Falun, Sweden J Ä and Department of Surgery, Umea University, Umea, Sweden T R
    Arterioscler Thromb Vasc Biol 33:2689-95. 2013
    ..Prospective data concerning the relation between circulating endostatin and mortality are lacking. Accordingly, we aimed to study associations between circulating endostatin and mortality risk...
  41. doi Involvement of inflammation in normal pregnancy
    Maria Palm
    Department of Women s and Children s Health, Obstetrics and Gynecology Uppsala University, Uppsala, Sweden
    Acta Obstet Gynecol Scand 92:601-5. 2013
    ..These results suggest that mild but significant inflammatory activity is involved in the development of normal pregnancy, which might have important physiological roles...
  42. doi Measurement of urinary cystatin C with a particle-enhanced turbidimetric immunoassay on Architect ci8200
    Feria Hikmet Noraddin
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    J Clin Lab Anal 26:358-64. 2012
    ..Urinary cystatin C is a potential biomarker for tubular damage including acute kidney injury (AKI) in the acute phase when patients are submitted to the intensive care unit...
  43. doi Counteraction of early circulatory derangement by administration of low dose steroid treatment at the onset of established endotoxemic shock is not directly mediated by TNF-α and IL-6
    Ewa Söderberg
    Section of Anaesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Steroids 77:1101-6. 2012
    ..We aimed to prospectively evaluate effects of early administrated hydrocortisone therapy on physiologic variables in a porcine model of septic shock...
  44. pmc Biomarkers of extracellular matrix metabolism (MMP-9 and TIMP-1) and risk of stroke, myocardial infarction, and cause-specific mortality: cohort study
    Jonas Hansson
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e16185. 2011
    ..An altered extracellular matrix metabolism has been implicated in a variety of diseases. We investigated relations of serum levels of MMP-9 and TIMP-1 to mortality risk from an etiological perspective...
  45. doi Fibrinogen and histidine-rich glycoprotein in early-onset preeclampsia
    Karin Kårehed
    Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden
    Acta Obstet Gynecol Scand 89:131-9. 2010
    ..To determine whether plasma levels of fibrinogen and the placental tissue distributions of fibrinogen and histidine-rich glycoprotein (HRG) differ between early- and late-onset preeclampsia...
  46. doi Prevalence and pathophysiological mechanisms of elevated cardiac troponin I levels in a population-based sample of elderly subjects
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Eur Heart J 29:2252-8. 2008
    ....
  47. ncbi Early inflammation mainly affects normally and poorly aerated lung in experimental ventilator-induced lung injury*
    João Batista Borges
    1Hedenstierna Laboratory, Department of Surgical Sciences, Section of Anaesthesiology and Critical Care, Uppsala University, Uppsala, Sweden 2Pulmonary Divison, Heart Institute InCor Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil 3Research and Education Institute, Hospital Sirio Libanes, Sao Paulo, Brazil 4Centros de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain 5Department of Hospital Physics, Uppsala University Hospital, Uppsala, Sweden 6Hedenstierna Laboratory, Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Crit Care Med 42:e279-87. 2014
    ..The aim of this study was to assess the location and magnitude of lung inflammation using PET imaging of [(18)F]fluoro-2-deoxy-D-glucose in a porcine experimental model of early acute respiratory distress syndrome...
  48. ncbi The presence of anti-p53 antibodies in sera from patients with oesophageal carcinoma: correlation to treatment, tumour volume and survival
    Stefan Bergström
    Department of Oncology, University Hospital, Uppsala, Sweden
    In Vivo 18:615-20. 2004
    ..The aim of the present study was to analyse anti-p53 antibodies in sera from patients with oesophageal carcinoma and their implications for clinical outcome and survival..
  49. doi The identification of a phospholipase B precursor in human neutrophils
    Shengyuan Xu
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Sweden
    FEBS J 276:175-86. 2009
    ..The existence of the PLB precursor in neutrophils and its enzymatic activity against phospholipids suggest a role in the defence against invading microorganisms and in the generation of lipid mediators of inflammation...
  50. doi Endothelial function in resistance and conduit arteries and 5-year risk of cardiovascular disease
    Lars Lind
    Department of Medical Sciences, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Circulation 123:1545-51. 2011
    ..Little is known of the relations of measures of endothelial function in resistance and conduit arteries to incident cardiovascular disease in the general population, and available techniques have not been compared...
  51. doi Reference values for 27 clinical chemistry tests in 70-year-old males and females
    Lena Carlsson
    Department of Medical Sciences, Uppsala University, Sweden
    Gerontology 56:259-65. 2010
    ..These values are not optimal for elderly patients, as many biological markers change over time and adequate reference values are important for correct clinical decisions...
  52. ncbi Slight increase of serum S-100B during porcine endotoxemic shock may indicate blood-brain barrier damage
    Anders Larsson
    Department of Medical Sciences, University Hospital S 751 85 Uppsala, Sweden
    Anesth Analg 101:1465-9. 2005
    ..However, it cannot be excluded that the increase in S-100B could be caused by release from organs other than the brain...
  53. ncbi Apolipoprotein A1 is a stronger prognostic marker than are HDL and LDL cholesterol for cardiovascular disease and mortality in elderly men
    Gösta Florvall
    Section of Clinical Chemistry, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    J Gerontol A Biol Sci Med Sci 61:1262-6. 2006
    ..Serum ApoA1 is a better risk marker than are ApoB, ApoB/ApoA1 ratio, HDL-C, and LDL-C for cardiovascular disease and mortality in elderly men...
  54. ncbi Inflammatory activity: capillary electrophoresis provides more information than erythrocyte sedimentation rate
    Anders Larsson
    Department of Medical Sciences, Clinical Chemistry and Pharmacology, University Hospital, Uppsala, Sweden
    Ups J Med Sci 110:151-8. 2005
    ..ESR determinations have been performed for more than eighty years and it is still one of the most frequently used laboratory tests, mainly to monitor the inflammatory response and as a tumour marker...
  55. doi Insulin-like growth factor binding protein-1 (IGFBP-1) during normal pregnancy
    Anders Larsson
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Gynecol Endocrinol 29:129-32. 2013
    ..To be able to evaluate IGFBP-1 values during pregnancy it is important to establish normal values in pregnant women...
  56. pmc Endotoxin tolerance variation over 24 h during porcine endotoxemia: association with changes in circulation and organ dysfunction
    Markus Castegren
    Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e53221. 2013
    ..In this study a temporal variation of ET was demonstrated that did not follow changes in plasma TNF-α concentrations. Maximal ET occurred early in the course and the higher the ET, the more hyperdynamic the circulation 18 h later...
  57. doi Human prostasomes express glycolytic enzymes with capacity for ATP production
    K Göran Ronquist
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Am J Physiol Endocrinol Metab 304:E576-82. 2013
    ..There is no clear-cut function linked to this subset of prostasomal proteins, but some possible roles are discussed...
  58. ncbi Early endotoxin-mediated haemostatic and inflammatory responses in the clopidogrel-treated pig
    Miklos Lipcsey
    Section of Anaesthesiology and Critical Care, Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Platelets 16:408-14. 2005
    ..Besides a trend to preserve renal function, clopidogrel did not affect haemodynamics or the coagulatory and inflammatory responses in porcine endotoxemia...
  59. pmc The role of circulating anti-p53 antibodies in patients with advanced non-small cell lung cancer and their correlation to clinical parameters and survival
    Michael Bergqvist
    Department of Oncology, University Hospital, 751 85 Uppsala, Sweden
    BMC Cancer 4:66. 2004
    ..Consequently, since antibodies against p53 (anti-p53 antibodies) are associated with mutations within the p53 gene it seems likely that these antibodies could, hypothetically, be correlated with prognosis...
  60. doi Pentraxin 3 values during normal pregnancy
    Anders Larsson
    Department of Medical Sciences, Clinical Chemistry, Uppsala University Hospital, 751 85, Uppsala, Sweden
    Inflammation 34:448-51. 2011
    ..5 and 97.5 percentiles for each sample period was calculated. There was a continuous increase of serum PTX3 as pregnancy progressed. The increase was most evident after week 31 with the highest levels just before delivery...
  61. doi Human prostasomes contain chromosomal DNA
    K Göran Ronquist
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
    Prostate 69:737-43. 2009
    ..The aim of this study was to perform a comprehensive evaluation of the occurrence of DNA in human prostasomes...
  62. ncbi Low diurnal variability of apolipoprotein A1, apolipoprotein B and apolipoprotein B/apolipoprotein A1 ratio during normal sleep and after an acute shift of sleep
    Anders Larsson
    Section of Clinical Chemistry, Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden
    Clin Biochem 41:859-62. 2008
    ..The aim of this study was to study the diurnal variation of the cardiovascular risk markers apolipoprotein A1 and B and apo B/apo A1 ratio...
  63. doi Prostasomal DNA characterization and transfer into human sperm
    Göran K Ronquist
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Mol Reprod Dev 78:467-76. 2011
    ..Fluorescence microscopy of slices in the center of 14 optical slides of the sperm head displayed an even fluorescence rather than a halo-like one, indicating DNA-uptake rather than just binding along the sperm head membrane...
  64. ncbi Antiprostasome antibodies: possible serum markers for prostate cancer metastasizing liability
    Anders Larsson
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Uppsala, Sweden
    Urol Oncol 24:195-200. 2006
    ..035) and pT (P = 0.025). These results indicate that the antiprostasome antibody titer in serum may be a novel marker for prostate cancer liability to metastasize...
  65. ncbi Flow cytometric technique for determination of prostasomal quantity, size and expression of CD10, CD13, CD26 and CD59 in human seminal plasma
    Lena Carlsson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Int J Androl 29:331-8. 2006
    ..Flow cytometry is a practical way to study prostasomes in seminal fluid without prior separation. This is a new technique for evaluation of the role of prostasomes and their functions in male reproductive physiology...
  66. doi Serum MMP-9 and TIMP-1 concentrations and MMP-9 activity during surgery-induced inflammation in humans
    Johanna Helmersson-Karlqvist
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Clin Chem Lab Med 50:1115-9. 2012
    ..This study investigates MMP-9 and TIMP-1 concentrations and MMP-9 activity at different time points after major surgery when a state of noticeable inflammation is expected...
  67. ncbi Cystatin C vs creatinine as markers of renal function in patients on digoxin treatment
    Par Hallberg
    Department of Medical Sciences, Clinical Chemistry and Pharmacology, University Hospital, Uppsala, Sweden
    Ups J Med Sci 109:247-53. 2004
    ..Serum cystatin C has been suggested to be superior to creatinine for estimation of GFR, which may have relevance for the optimization of treatment with digoxin...
  68. ncbi Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community
    Majd A I Mirza
    Department of Medical Sciences, Uppsala University Hospital, Sweden
    Atherosclerosis 205:385-90. 2009
    ..Since CV disease is a major cause of death in CKD, we investigated the association between FGF23 and vascular function...
  69. ncbi Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis
    Vladimir Bourlev
    Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden
    Fertil Steril 94:52-7. 2010
    ..Further, we addressed the question of whether surgical removal of endometriotic lesions was associated with normalization of the serum concentrations of the same markers...
  70. doi Cystatin C levels are positively correlated with both Abeta42 and tau levels in cerebrospinal fluid in persons with Alzheimer's disease, mild cognitive impairment, and healthy controls
    Johan Sundelöf
    Uppsala University, Department of Public Health Geriatrics, Uppsala, Sweden
    J Alzheimers Dis 21:471-8. 2010
    ..Interestingly, cystatin C levels were positively correlated with both tau and Abeta42 levels in CSF independent of age, gender, and APOE genotype...
  71. ncbi Mucosal secretion and expression of basic fibroblast growth factor in patients with collagenous colitis
    Yesuf Taha
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    Am J Gastroenterol 98:2011-7. 2003
    ..In this study we examined the secretion and expression of bFGF in the colorectal mucosa of patients with CC...
  72. ncbi Biochemical indicators of cardiac and renal function in a healthy elderly population
    Nina Johnston
    Department of Medical Sciences, Cardiology, University Hospital, Uppsala, Sweden
    Clin Biochem 37:210-6. 2004
    ..To examine the distributions of NT-proBNP and cystatin C and their relation to age, gender, and other physiological factors in an apparently healthy elderly population...
  73. doi Influences of sleep and the circadian rhythm on iron-status indices
    Peter Ridefelt
    Section of Clinical Chemistry, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Clin Biochem 43:1323-8. 2010
    ..The aim was to study the influence of sampling time, food intake and sleep on tests used to screen for and monitor conditions of iron deficiency and overload...
  74. ncbi Mode of growth determines differential expression of prostasomes in cultures of prostate cancer cell lines and opens for studies of prostasome gene expression
    Lena Carlsson
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
    Ups J Med Sci 111:293-301. 2006
    ..Thus it should be possible to apply cDNAmicroarray analyses for characterizing the genes which are active at the cellular expression of prostasomes and then deduce the prostasome antigens...
  75. doi Good effect of IgY against Pseudomonas aeruginosa infections in cystic fibrosis patients
    Elin Nilsson
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Pediatr Pulmonol 43:892-9. 2008
    ..730) within the IgY group. Body mass index values were normal or close to normal for all IgY treated patients. In conclusion, Anti-Pseudomonas IgY has great potential to prevent P. aeruginosa infections...
  76. ncbi Serum amyloid A (SAA) protein and high-sensitivity C-reactive protein (hsCRP) in healthy newborn infants and healthy young through elderly adults
    Anders Lannergård
    Department of Medical Sciences, Infectious Diseases, Internal Medicine and Clinical Chemistry, Uppsala University Hospital, Uppsala, Sweden
    Acta Paediatr 94:1198-202. 2005
    ..To determine the levels of serum amyloid A (SAA) protein and high-sensitivity C-reactive protein (hsCRP) in different age groups...
  77. ncbi Cystatin C: a novel predictor of outcome in suspected or confirmed non-ST-elevation acute coronary syndrome
    Tomas Jernberg
    Department of Medical Sciences, Cardiology, Uppsala Research Center, University Hospital, 751 85 Uppsala, Sweden
    Circulation 110:2342-8. 2004
    ..Cystatin C is a new and better marker of renal function than creatinine. The aim was therefore to evaluate the prognostic value of cystatin C in this population...
  78. pmc A population pharmacokinetic model for cefuroxime using cystatin C as a marker of renal function
    Anders Viberg
    Division of Pharmokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
    Br J Clin Pharmacol 62:297-303. 2006
    ..The aim of this prospective study was to develop a population model that describes the pharmacokinetics of cefuroxime and to investigate the usefulness of CysC as a covariate of the model parameters...
  79. ncbi Retention of specific yolk IgY in the human oral cavity
    David Carlander
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
    BioDrugs 16:433-7. 2002
    ..Oral treatment could potentially be used against many frequently encountered diseases (e.g. common cold, tonsillitis and caries). GROUP STUDIED: Healthy volunteers...
  80. pmc Endotoxin neutralization and anti-inflammatory effects of tobramycin and ceftazidime in porcine endotoxin shock
    Gunilla Goscinski
    Section of Infectious Diseases, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Crit Care 8:R35-41. 2004
    ..The aim of the present study was to investigate whether the biological effects of endotoxin in a porcine model could be neutralized by tobramycin, and whether tobramycin or ceftazidime was able to modulate the inflammatory response...
  81. ncbi Evaluation of laboratory markers for the detection of infections in open-heart surgery patients
    Anders Lannergård
    Department of Medical Sciences, Sections of Infectious Diseases and Clinical Chemistry, Uppsala University Hospital, Uppsala, Sweden
    Scand J Infect Dis 35:121-6. 2003
    ..HNL and WBC counts were ineffectual as indicators of postoperative infections in this study...
  82. ncbi Coagulation, fibrinolysis, and cell activation in patients and shed mediastinal blood during coronary artery bypass grafting with a new heparin-coated surface
    Matilda Johnell
    Department of Medical Sciences, Clinical Chemistry, Laboratory for Coagulation Research, University Hospital, SE 751 85 Uppsala, Sweden
    J Thorac Cardiovasc Surg 124:321-32. 2002
    ....
  83. ncbi Improved blood compatibility of a stent graft by combining heparin coating and abciximab
    Kjeld Christensen
    Department of Cardiology, University Hospital, Orebro, S 701 85, Sweden
    Thromb Res 115:245-53. 2005
    ..The aim of this study was to assess the combined effect of heparin coating of a stent graft and administration of abciximab, on platelet and coagulation activity in vitro...
  84. ncbi Association of type 2 diabetes with cyclooxygenase-mediated inflammation and oxidative stress in an elderly population
    Johanna Helmersson
    Section of Geriatrics and Clinical Nutrition Research, Uppsala University, Uppsala, Sweden
    Circulation 109:1729-34. 2004
    ..Involvement of cyclooxygenase (COX)-mediated inflammation in type 2 diabetes has not been studied, and the association between cytokine-mediated inflammation and diabetes is not fully clarified...
  85. ncbi Proteomic characterization of IgY preparations purified with a water dilution method
    Elin Nilsson
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, SE 751 85 Uppsala, Sweden
    J Agric Food Chem 56:11638-42. 2008
    ..The concentrations of cholesterols and triglycerides were low and should not have an effect on the plasma levels of treated patients. Purification of IgY for oral use with WD is therefore a recommended method...
  86. ncbi Chicken anti-protein L for the detection of small amounts of protein L in the presence of IgG
    Elin Nilsson
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
    Hybridoma (Larchmt) 24:112-4. 2005
    ..Protein L does not react with chicken IgY light chains, and it is therefore possible to make an antigen-specific assay. The assay can be used to detect protein L at a concentration of 0.3 ng/mL in the presence of IgG...
  87. ncbi Analysis of inflammatory response in human plasma samples by an automated multicapillary electrophoresis system
    Anders Larsson
    Department of Medical Sciences, Clinical Chemistry, University Hospital, 751 85 Uppsala, Sweden
    Clin Chem Lab Med 42:1396-400. 2004
    ..The HR buffer in combination with albumin quantification allows the simultaneous quantification of inflammatory markers in plasma samples without the need for nephelometric determination of these proteins...
  88. ncbi Characteristics of human prostasomes isolated from three different sources
    Lena Carlsson
    Department of Medical Sciences, Clinical Chemistry Unit, University Hospital, Uppsala, Sweden
    Prostate 54:322-30. 2003
    ..Prostasomes are organelles secreted by human prostate epithelial cells and appear freely in semen. Most prostasomal functional and biochemical characteristics have been settled on basis of seminal prostasomes (SP)...
  89. pmc Use of the probiotic Lactobacillus plantarum 299 to reduce pathogenic bacteria in the oropharynx of intubated patients: a randomised controlled open pilot study
    Bengt Klarin
    Department of Anaesthesiology and Intensive Care, University Hospital, SE 221 85 Lund, Sweden
    Crit Care 12:R136. 2008
    ....
  90. doi Postsurgical inflammatory response is not associated with increased serum cystatin C values
    Torbjörn Akerfeldt
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Clin Biochem 43:1138-40. 2010
    ..The aim of this study was to evaluate if an induced inflammatory response has an effect on cystatin C levels in humans...
  91. ncbi Long-term effects of an education programme on the optimal use of clinical chemistry testing in primary health care
    Mirja Mindemark
    Department of Clinical Chemistry, Akademiska sjukhuset, Uppsala, Sweden
    Scand J Clin Lab Invest 69:481-6. 2009
    ..The aim of this study was to investigate whether continuing education on the optimal use of clinical chemistry testing in primary health care has had any long-term effects on the test-ordering behaviour of the participating physicians...
  92. ncbi Oral administration of specific yolk antibodies (IgY) may prevent Pseudomonas aeruginosa infections in patients with cystic fibrosis: a phase I feasibility study
    Hans Kollberg
    Uppsala CF Center, Department of Women s and Children s Health, University Hospital, Uppsala, Sweden
    Pediatr Pulmonol 35:433-40. 2003
    ..This feasibility study shows that antipseudomonal IgY has the potential to effectively prevent PA colonization without any severe adverse effects. A phase III study should be initiated...
  93. ncbi Variations in assay protocol for the Dako cystatin C method may change patient results by 50% without changing the results for controls
    Mats Flodin
    Department of Medical Sciences, Clinical Chemistry, University Hospital, 751 85 Uppsala, Sweden
    Clin Chem Lab Med 44:1481-5. 2006
    ..Cystatin C is increasingly used as a glomerular filtration marker, but so far only a few companies produce most of the cystatin C reagents suited for turbidimetry or nephelometry use in clinical laboratories...
  94. ncbi Placental growth factor and soluble FMS-like tyrosine kinase-1 in early-onset and late-onset preeclampsia
    Anna Karin Wikström
    Departments of Women s and Children s Health, Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
    Obstet Gynecol 109:1368-74. 2007
    ....
  95. ncbi Particulate platform for bioluminescent immunosensing
    Karin Fromell
    Department of Physical and Analytical Chemistry, Uppsala University, Uppsala, Sweden
    Anal Chem 79:8601-7. 2007
    ..Under the biochemical conditions employed here, the detection limit of the pyruvate kinase conjugate lies in the femtomole range...
  96. ncbi Biochemical effects of consumption of eggs containing omega-3 polyunsaturated fatty acids
    Marie Ohman
    Primary Health Care, Landstinget Västmanland, Section of Clinical Chemistry, Uppsala University Hospital, Uppsala, Sweden
    Ups J Med Sci 113:315-23. 2008
    ..These effects have been associated in previous studies with a reduced risk for cardiovascular mortality and diabetes...
  97. doi Performance evaluation of a particle-enhanced turbidimetric cystatin C assay on the Abbott ci8200 analyzer
    Mats Flodin
    Department of Clinical Chemistry and Pharmacology, University Hospital, Uppsala, Sweden
    Clin Biochem 42:873-6. 2009
    ..There is a need for cystatin C assays adapted to routine chemistry instrument to minimize turnaround times and allowing 24 h/day availability...
  98. doi F2-isoprostane, inflammation, cardiac function and oxygenation in the endotoxaemic pig
    Miklos Lipcsey
    Section of Anaesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University Hospital, 751 85 Uppsala, Sweden
    Prostaglandins Leukot Essent Fatty Acids 78:209-17. 2008
    ..Furthermore, formation of these eicosanoids on endotoxin-mediated alterations in pulmonary hypertension, oxygen delivery and oxygen utilisation seems to be independent of the administered endotoxin dose...
  99. ncbi Evaluation of Dade Behring N Latex Cystatin C reagent on Abbott ci8200
    Mats Flodin
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Ups J Med Sci 111:209-13. 2006
    ..0072x + 0.0042; R2 = 0.987). Accordingly, running the cystatin C analyses on a chemistry instrument (Architect ci8200) would be proper to increase the availability of the analysis and reduce turnaround times...
  100. ncbi Antioxidant intake, oxidative stress and inflammation among immigrant women from the Middle East living in Sweden: associations with cardiovascular risk factors
    Achraf Daryani
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, 751 85 Uppsala, Sweden
    Nutr Metab Cardiovasc Dis 17:748-56. 2007
    ..We also investigated relationships between F(2)-isoprostanes, CRP and cardiovascular risk factors...
  101. ncbi Serum semicarbazide-sensitive amine oxidase (SSAO) activity correlates with VEGF in non-small-cell lung cancer patients
    Håkan Garpenstrand
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, 751 85 Uppsala, Sweden
    Med Oncol 21:241-50. 2004
    ..However, a strong correlation between serum SSAO activity and the angiogenic factor VEGF was found that might implicate new aspects of the mechanisms controlling angiogenesis...