Björn Hultberg

Summary

Affiliation: University Hospital
Country: Sweden

Publications

  1. ncbi request reprint Hypomethylation as a cause of homocysteine-induced cell damage in human cell lines
    B Hultberg
    Department of Clinical Chemistry, Institute for Laboratory Medicine, University Hospital, Lund, Sweden
    Toxicology 147:69-75. 2000
  2. ncbi request reprint Elimination of high amounts of extracellular homocysteine in human cell lines
    Björn Hultberg
    Institute of Laboratory Medicine, Department of Clinical Chemistry, University Hospital, S 22185 Lund, Sweden
    Clin Chim Acta 356:117-24. 2005
  3. ncbi request reprint High glutathione turnover in human cell lines revealed by acivicin inhibition of gamma-glutamyltranspeptidase and the effects of thiol-reactive metals during acivicin inhibition
    Björn Hultberg
    Institute of Laboratory Medicine, Department of Clinical Chemistry, University Hospital, Lund S 22185, Sweden
    Clin Chim Acta 349:45-52. 2004
  4. ncbi request reprint Extracellular concentration of homocysteine in human cell lines is influenced by specific inhibitors of cyst(e)ine transport
    Björn Hultberg
    Institute of Laboratory Medicine, Department of Clinical Chemistry, University Hospital, Lund, Sweden
    Clin Chem Lab Med 42:378-83. 2004
  5. ncbi request reprint [Optimal use of markers for cobalamin/folate status. Results from a survey in a group of psychogeriatric patients]
    Björn Hultberg
    Kliniskt kemiska laboratoriet, Universitetssjukhuset i Lund
    Lakartidningen 100:3136-40. 2003
  6. ncbi request reprint Folate deficiency is a common finding in psychogeriatric patients
    Björn Hultberg
    Department of Laboratory Medicine, Division of Clinical Chemistry, University Hospital, Lund, Sweden
    Aging Clin Exp Res 14:479-84. 2002
  7. ncbi request reprint Modulation of extracellular homocysteine concentration in human cell lines
    Björn Hultberg
    Department of Clinical Chemistry, Institute of Laboratory Medicine, University Hospital, S 22185 Lund, Sweden
    Clin Chim Acta 330:151-9. 2003
  8. ncbi request reprint Thiol redox status influences extracellular concentration of homocysteine in HeLa cell cultures
    B Hultberg
    Institute for Laboratory Medicine, Department of Clinical Chemistry, University Hospital, Lund, Sweden
    Clin Chem Lab Med 38:1243-7. 2000
  9. ncbi request reprint Elevated plasma homocysteine level is not primarily related to Alzheimer's disease
    Karin Nilsson
    Departments of Psychogeriatrics, Clinical Science, Lund University Hospital, Lund, Sweden
    Dement Geriatr Cogn Disord 34:121-7. 2012
  10. doi request reprint Plasma homocysteine and cognition in elderly patients with dementia or other psychogeriatric diseases
    Karin Nilsson
    Department of Psychogeriatrics, Clinical Science, Lund University Hospital, Lund, Sweden
    Dement Geriatr Cogn Disord 30:198-204. 2010

Detail Information

Publications28

  1. ncbi request reprint Hypomethylation as a cause of homocysteine-induced cell damage in human cell lines
    B Hultberg
    Department of Clinical Chemistry, Institute for Laboratory Medicine, University Hospital, Lund, Sweden
    Toxicology 147:69-75. 2000
    ..Thus, it is likely that several mechanisms of homocysteine-induced cell damage contribute to the increased rate of the atherogenic process observed in hyperhomocysteinemia...
  2. ncbi request reprint Elimination of high amounts of extracellular homocysteine in human cell lines
    Björn Hultberg
    Institute of Laboratory Medicine, Department of Clinical Chemistry, University Hospital, S 22185 Lund, Sweden
    Clin Chim Acta 356:117-24. 2005
    ..Information about the metabolism of homocysteine is therefore essential for an understanding of its role in atherogenesis, thereby enabling a modulation of that risk...
  3. ncbi request reprint High glutathione turnover in human cell lines revealed by acivicin inhibition of gamma-glutamyltranspeptidase and the effects of thiol-reactive metals during acivicin inhibition
    Björn Hultberg
    Institute of Laboratory Medicine, Department of Clinical Chemistry, University Hospital, Lund S 22185, Sweden
    Clin Chim Acta 349:45-52. 2004
    ..Glutathione is known to have multifaceted physiological functions and is a critical factor in protecting organisms against toxicity and disease. Intracellular cysteine concentration is a limiting factor for glutathione synthesis...
  4. ncbi request reprint Extracellular concentration of homocysteine in human cell lines is influenced by specific inhibitors of cyst(e)ine transport
    Björn Hultberg
    Institute of Laboratory Medicine, Department of Clinical Chemistry, University Hospital, Lund, Sweden
    Clin Chem Lab Med 42:378-83. 2004
    ....
  5. ncbi request reprint [Optimal use of markers for cobalamin/folate status. Results from a survey in a group of psychogeriatric patients]
    Björn Hultberg
    Kliniskt kemiska laboratoriet, Universitetssjukhuset i Lund
    Lakartidningen 100:3136-40. 2003
    ..These findings suggest the use of plasma homocysteine, serum cobalamin and serum folate to evaluate cobalamin/folate status in psychogeriatric patients, whereas the use of serum methylmalonic acid and whole blood folate could be omitted...
  6. ncbi request reprint Folate deficiency is a common finding in psychogeriatric patients
    Björn Hultberg
    Department of Laboratory Medicine, Division of Clinical Chemistry, University Hospital, Lund, Sweden
    Aging Clin Exp Res 14:479-84. 2002
    ..The objective of the present study was to obtain detailed information on folate status in psychogeriatric patients and its association with elevated tHcy concentration...
  7. ncbi request reprint Modulation of extracellular homocysteine concentration in human cell lines
    Björn Hultberg
    Department of Clinical Chemistry, Institute of Laboratory Medicine, University Hospital, S 22185 Lund, Sweden
    Clin Chim Acta 330:151-9. 2003
    ..Information about the metabolism of homocysteine is, therefore, essential for an understanding of its role in atherogenesis, thereby enabling a modulation of that risk...
  8. ncbi request reprint Thiol redox status influences extracellular concentration of homocysteine in HeLa cell cultures
    B Hultberg
    Institute for Laboratory Medicine, Department of Clinical Chemistry, University Hospital, Lund, Sweden
    Clin Chem Lab Med 38:1243-7. 2000
    ..These effects are probably dependent on differences in cellular uptake between reduced and oxidized homocysteine...
  9. ncbi request reprint Elevated plasma homocysteine level is not primarily related to Alzheimer's disease
    Karin Nilsson
    Departments of Psychogeriatrics, Clinical Science, Lund University Hospital, Lund, Sweden
    Dement Geriatr Cogn Disord 34:121-7. 2012
    ..A moderate elevation of plasma total homocysteine (tHcy) is considered a potential risk factor for Alzheimer's disease (AD)...
  10. doi request reprint Plasma homocysteine and cognition in elderly patients with dementia or other psychogeriatric diseases
    Karin Nilsson
    Department of Psychogeriatrics, Clinical Science, Lund University Hospital, Lund, Sweden
    Dement Geriatr Cogn Disord 30:198-204. 2010
    ..Increasing evidence indicates that vascular risk factors play a role in the development of cognitive impairment...
  11. ncbi request reprint Elevated plasma homocysteine concentration in elderly patients with mental illness is mainly related to the presence of vascular disease and not the diagnosis
    Karin Nilsson
    Department of Psychogeriatrics, Clinical Science, Division of Clinical Chemistry, Lund University Hospital, Lund, Sweden
    Dement Geriatr Cogn Disord 24:162-8. 2007
    ....
  12. ncbi request reprint Lipoic acid increases glutathione production and enhances the effect of mercury in human cell lines
    Björn Hultberg
    Department of Clinical Chemistry, Institute of Laboratory Medicine, University Hospital Lund, S 22185 Lund, Sweden
    Toxicology 175:103-10. 2002
    ..Thus, metabolic effects of mercury ions were observed in hepatoma cells as well as in HeLa cells at a lower concentration than the supposed toxicity threshold for mercury in blood...
  13. doi request reprint Plasma homocysteine, brain imaging and cognition in older patients with mental illness
    Karin Nilsson
    Department of Psychogeriatrics, Clinical Science, Lund University Hospital, Lund, Sweden
    Int J Geriatr Psychiatry 27:409-14. 2012
    ..Plasma tHcy has been reported to be associated with cognitive functions. The mechanism by which plasma tHcy may influence cognitive functions is not clear...
  14. ncbi request reprint Plasma homocysteine and markers for oxidative stress and inflammation in patients with coronary artery disease--a prospective randomized study of vitamin supplementation
    Torfi Jonasson
    Department of Cardiology, University Hospital Lund, Lund, Sweden
    Clin Chem Lab Med 43:628-34. 2005
    ..We also aimed to demonstrate the effects of vitamin supplementation on these markers...
  15. doi request reprint Plasma homocysteine--a marker of vascular disease in elderly patients with mental illness
    Karin Nilsson
    Department of Psychogeriatrics, Clinical Science, Lund University Hospital, S 22185 Lund, Sweden
    Clin Biochem 43:1056-9. 2010
    ..Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness, and patients with vascular disease have higher plasma tHcy concentration than patients without vascular disease...
  16. doi request reprint Plasma homocysteine levels and different forms of vascular disease in patients with dementia and other psychogeriatric diseases
    Karin Nilsson
    Department of Psychogeriatrics and Clinical Science, Lund University Hospital, Lund, Sweden
    Dement Geriatr Cogn Disord 27:88-95. 2009
    ..Total plasma homocysteine (tHcy) concentration is elevated in patients with psychogeriatric disease. There are many different determinants of plasma tHcy concentration, including the presence of vascular disease...
  17. doi request reprint C-reactive protein: vascular risk marker in elderly patients with mental illness
    Karin Nilsson
    Department of Psychogeriatrics, Clinical Science, Lund University Hospital, Lund, Sweden
    Dement Geriatr Cogn Disord 26:251-6. 2008
    ..Clarification of the role of vascular risk factors in dementia is important because most are modifiable, in contrast to other risk factors such as age and genetics...
  18. doi request reprint Plasma homocysteine and vascular disease in elderly patients with mental illness
    Karin Nilsson
    Department of Psychogeriatrics, Clinical Science, Lund University Hospital, Lund, Sweden
    Clin Chem Lab Med 46:1556-61. 2008
    ..Furthermore, it seems possible that the control of conventional vascular risk factors could be guided by the level of plasma tHcy, serum cystatin C, serum N-terminal pro-brain natriuretic peptide, and serum C-reactive protein...
  19. doi request reprint C-reactive protein level is decreased in patients with Alzheimer's disease and related to cognitive function and survival time
    Karin Nilsson
    Department of Psychogeriatrics, Clinical Science, Division of Clinical Chemistry, Lund University Hospital, S 22185 Lund, Sweden
    Clin Biochem 44:1205-8. 2011
    ..Previous studies have observed decreased serum CRP levels in patients with established Alzheimer's disease (AD) compared to controls or other diagnostic groups of elderly patients with mental illness...
  20. ncbi request reprint Plasma homocysteine is elevated in elderly patients with memory complaints and vascular disease
    Karin Nilsson
    Department of Psychogeriatrics, Clinical Science and Laboratory Medicine, Lund University Hospital, Lund, Sweden
    Dement Geriatr Cogn Disord 23:321-6. 2007
    ..The main objective of the present study was to investigate the relationship between plasma tHcy concentration and vascular disease in elderly patients with memory complaints...
  21. doi request reprint Survival in a large elderly population of patients with dementia and other forms of psychogeriatric diseases
    Karin Nilsson
    Department of Psychogeriatrics and Clinical Science, Institute of Laboratory Medicine, Lund University Hospital, Lund, Sweden
    Dement Geriatr Cogn Disord 32:342-50. 2011
    ..Better knowledge of prognosis in elderly patients affected by dementia or mental illness should be of great importance in order to improve care plans and assist in medical decisions...
  22. doi request reprint Plasma homocysteine, apolipoprotein E status and vascular disease in elderly patients with mental illness
    Karin Nilsson
    Department of Psychogeriatrics, Clinical Science, Lund University Hospital, Lund, Sweden
    Clin Chem Lab Med 48:129-35. 2010
    ..Apolipoprotein E (apoE) status is associated with cardiovascular disease and a major genetic risk factor is inheritance of the e4 allele. In the present study, we investigated the association between plasma tHcy and apoE status...
  23. doi request reprint The clinical use of N-terminal-pro brain natriuretic peptide in elderly patients with mental illness
    Karin Nilsson
    Department of Geriatric Psychiatry, Clinical Science, Lund University Hospital, S 22185 Lund, Sweden
    Clin Biochem 43:1282-6. 2010
    ..Vascular disease plays an important role in cognitive impairment in elderly patients with mental illness...
  24. ncbi request reprint Homocysteine, cystatin C and N-terminal-pro brain natriuretic Peptide. Vascular risk markers in elderly patients with mental illness
    Karin Nilsson
    Department of Psychogeriatrics, Clinical Science Lund University Hospital, Lund, Sweden
    Dement Geriatr Cogn Disord 25:88-96. 2008
    ..Clarification of the role of vascular risk factors in dementia is important because most are modifiable, in contrast to other risk factors such as age and genetics...
  25. ncbi request reprint Renal function exerts only a minor influence on high plasma homocysteine concentrations in patients with acute coronary syndromes
    Torfi Jonasson
    Department of Medicine, University of Lund, University Hospital, Sweden
    Clin Chem Lab Med 40:137-42. 2002
    ..These findings do not support the hypothesis that subtle renal dysfunction is an important cause of high plasma tHcy concentration in patients with acute coronary syndromes...
  26. pmc Elevated plasma homocysteine level in vascular dementia reflects the vascular disease process
    Karin Nilsson
    Department of Psychogeriatrics, Clinical Science, Lund University Hospital, Lund, Sweden
    Dement Geriatr Cogn Dis Extra 3:16-24. 2013
    ..Patients with vascular dementia (VaD) exhibit particularly elevated levels of plasma total homocysteine (tHcy) compared to patients with other psychogeriatric diseases...
  27. pmc The use of N-terminal pro-brain natriuretic Peptide to evaluate vascular disease in elderly patients with mental illness
    Karin Nilsson
    Department of Geriatric Psychiatry, Clinical Science, Lund University Hospital, Lund, Sweden
    Dement Geriatr Cogn Dis Extra 2:10-8. 2012
    ..Serum N-terminal pro-brain natriuretic peptide (NT-proBNP) is regarded as a sensitive marker of cardiovascular disease. Vascular disease plays an important role in cognitive impairment...
  28. ncbi request reprint Vitamin supplementation normalizes total plasma homocysteine concentration but not plasma homocysteine redox status in patients with acute coronary syndromes and hyperhomocysteinemia
    Anders Andersson
    Department of Clinical Chemistry, University Hospital, Lund, Sweden
    Clin Chem Lab Med 40:554-8. 2002
    ....