P Hellman

Summary

Affiliation: University Hospital
Country: Sweden

Publications

  1. ncbi request reprint Radiofrequency tissue ablation using cooled tip for liver metastases of endocrine tumors
    Per Hellman
    Department of Surgery, University Hospital, SE 751 85 Uppsala, Sweden
    World J Surg 26:1052-6. 2002
  2. ncbi request reprint Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells
    W Liu
    Department of Surgery, University Hospital, 751 85 Uppsala, Sweden
    Biochem Biophys Res Commun 229:922-9. 1996
  3. ncbi request reprint Effect of surgery on the outcome of midgut carcinoid disease with lymph node and liver metastases
    Per Hellman
    Department of Surgery, University Hospital, SE 751 85 Uppsala, Sweden
    World J Surg 26:991-7. 2002
  4. ncbi request reprint Surgical strategy for large or malignant endocrine pancreatic tumors
    P Hellman
    Department of Surgery, University Hospital, S 751 85 Uppsala, Sweden
    World J Surg 24:1353-60. 2000
  5. ncbi request reprint Pathophysiology of primary hyperparathyroidism
    P Hellman
    Department of Surgery, Uppsala University, Sweden
    Histol Histopathol 15:619-27. 2000
  6. ncbi request reprint Vitamin D receptor polymorphisms correlate to parathyroid cell function in primary hyperparathyroidism
    T Carling
    Department of Surgery, Uppsala University Hospital, Sweden
    J Clin Endocrinol Metab 82:1772-5. 1997
  7. ncbi request reprint Differentiation of human parathyroid cells in culture
    W Liu
    Department of Surgery, University Hospital, Uppsala, Sweden
    J Endocrinol 168:417-25. 2001
  8. ncbi request reprint Effects of calcium channel modulators on the regulation of cytoplasmic Ca2+ and hormone secretion of parathyroid cells
    P Ridefelt
    Department of Surgery, University Hospital, Uppsala, Sweden
    Pharmacol Toxicol 78:147-53. 1996
  9. ncbi request reprint Familial hypercalcemia and hypercalciuria caused by a novel mutation in the cytoplasmic tail of the calcium receptor
    T Carling
    Department of Surgery, Uppsala University Hospital, Sweden
    J Clin Endocrinol Metab 85:2042-7. 2000
  10. ncbi request reprint Somatostatin and octreotide interfere with calcium signalling in pancreatic beta-cells but not in normal and pathological parathyroid cells
    P Ridefelt
    Department of Surgery, University Hospital, Uppsala, Sweden
    Horm Metab Res 28:588-91. 1996

Detail Information

Publications40

  1. ncbi request reprint Radiofrequency tissue ablation using cooled tip for liver metastases of endocrine tumors
    Per Hellman
    Department of Surgery, University Hospital, SE 751 85 Uppsala, Sweden
    World J Surg 26:1052-6. 2002
    ..e., no residual macroscopic tumor) in 4 patients. We conclude that RF using cooled-tip needles is safe and efficient; it may be performed percutaneously and intraoperatively; and it may expand the indications for liver resection...
  2. ncbi request reprint Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells
    W Liu
    Department of Surgery, University Hospital, 751 85 Uppsala, Sweden
    Biochem Biophys Res Commun 229:922-9. 1996
    ..The present data establish parathyroid gland as a target for retinoids and as a site of synthesis of the hormonal forms of vitamin A (retinol), all-trans- and 9-cis-retinoic acid...
  3. ncbi request reprint Effect of surgery on the outcome of midgut carcinoid disease with lymph node and liver metastases
    Per Hellman
    Department of Surgery, University Hospital, SE 751 85 Uppsala, Sweden
    World J Surg 26:991-7. 2002
    ..Liver metastases and significant preoperative weight loss are identified as major negative prognostic factors for survival...
  4. ncbi request reprint Surgical strategy for large or malignant endocrine pancreatic tumors
    P Hellman
    Department of Surgery, University Hospital, S 751 85 Uppsala, Sweden
    World J Surg 24:1353-60. 2000
    ..The operations were performed with no mortality and low morbidity. We conclude that large and malignant EPTs with limited spread of disease may benefit from a combination of medical and surgical therapy...
  5. ncbi request reprint Pathophysiology of primary hyperparathyroidism
    P Hellman
    Department of Surgery, Uppsala University, Sweden
    Histol Histopathol 15:619-27. 2000
    ..This review summarizes data on regulation of PTH release, dysregulation in HPT, as well as proliferation of parathyroid cells...
  6. ncbi request reprint Vitamin D receptor polymorphisms correlate to parathyroid cell function in primary hyperparathyroidism
    T Carling
    Department of Surgery, Uppsala University Hospital, Sweden
    J Clin Endocrinol Metab 82:1772-5. 1997
    ..05). As VDR alleles were unrelated to parathyroid intracellular Ca2+, influences of polymorphic VDR alleles on PTH secretion seem to involve mechanisms other than the Ca2+-sensing protein of the parathyroid cell surface...
  7. ncbi request reprint Differentiation of human parathyroid cells in culture
    W Liu
    Department of Surgery, University Hospital, Uppsala, Sweden
    J Endocrinol 168:417-25. 2001
    ..The low calcium stimulated cell proliferation may also be inhibited by vitamin D and RA...
  8. ncbi request reprint Effects of calcium channel modulators on the regulation of cytoplasmic Ca2+ and hormone secretion of parathyroid cells
    P Ridefelt
    Department of Surgery, University Hospital, Uppsala, Sweden
    Pharmacol Toxicol 78:147-53. 1996
    ..However, these actions are not sufficiently pronounced and tissue specific to allow their use for correcting hyperparathyroidism...
  9. ncbi request reprint Familial hypercalcemia and hypercalciuria caused by a novel mutation in the cytoplasmic tail of the calcium receptor
    T Carling
    Department of Surgery, Uppsala University Hospital, Sweden
    J Clin Endocrinol Metab 85:2042-7. 2000
    ..The hypercalcemic disorder of the present family is caused by an inactivating point mutation in the cytoplasmic tail of the CaR and displays clinical characteristics atypical of FHH and primary HPT...
  10. ncbi request reprint Somatostatin and octreotide interfere with calcium signalling in pancreatic beta-cells but not in normal and pathological parathyroid cells
    P Ridefelt
    Department of Surgery, University Hospital, Uppsala, Sweden
    Horm Metab Res 28:588-91. 1996
    ..The results indicate that somatostatin and octreotide lack direct actions on parathyroid cells, which contrasts to their effects on calcium signalling in cells from pancreatic islets...
  11. ncbi request reprint Regulation of gp330/megalin expression by vitamins A and D
    W Liu
    University Hospital, Uppsala, Sweden
    Eur J Clin Invest 28:100-7. 1998
    ..This molecule, known as gp330/megalin, is among several tissues present in the proximal tubule, parathyroid and placental cytotrophoblasts, in which a Ca2+-sensing function has been demonstrated...
  12. ncbi request reprint Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas
    O Hessman
    Department of Surgery, University Hospital, Uppsala, Sweden
    Cancer Res 58:377-9. 1998
    ..These findings support the hypothesis that MEN1 gene mutations contribute to the tumorigenesis of nonfamilial, malignant endocrine pancreatic tumors...
  13. ncbi request reprint Characterization of the human Megalin/LRP-2 promoter in vitro and in primary parathyroid cells
    A Knutson
    Department of Surgery, Uppsala University Hospital, Sweden
    DNA Cell Biol 17:551-60. 1998
    ....
  14. ncbi request reprint 25-hydroxyvitamin D3 1alpha-hydroxylase and vitamin D receptor expression in papillary thyroid carcinoma
    K Khadzkou
    Department of Surgical Sciences, University Hospital, Uppsala, Sweden
    J Histochem Cytochem 54:355-61. 2006
    ..Expression of VDR and 1-alpha-hydroxylase in PTC may be compatible with an overall favorable prognosis for this tumor type and may constitute important prerequisites for using vitamin D and/or vitamin D analogs in the treatment of PTC...
  15. ncbi request reprint Endoscopic ultrasonography for evaluation of pancreatic tumours in multiple endocrine neoplasia type 1
    P Hellman
    Department of Surgery, University Hospital, SE 751 85 Uppsala, Sweden
    Br J Surg 92:1508-12. 2005
    ..During the past decade, endoscopic ultrasonography (EUS) has evolved as a sensitive method for the detection of small pancreatic lesions...
  16. ncbi request reprint Vitamin D receptor alleles b, a, and T: risk factors for sporadic primary hyperparathyroidism (HPT) but not HPT of uremia or MEN 1
    T Carling
    Department of Surgery, Uppsala University Hospital, Sweden
    Biochem Biophys Res Commun 231:329-32. 1997
    ..0006-0.0001), whereas HPT of MEN 1 and uremia seemed unrelated to the VDR polymorphisms (p = 0.26-0.96). The results suggest that the VDR alleles b, a, and T are novel risk factors in the essentially uncharacterized pathogenesis of spHPT...
  17. doi request reprint Randomized clinical trial comparing open with video-assisted minimally invasive parathyroid surgery for primary hyperparathyroidism
    O Hessman
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Br J Surg 97:177-84. 2010
    ..The aim of the present study was to compare open minimally invasive parathyroidectomy with the video-assisted technique for primary hyperparathyroidism in a multicentre randomized trial...
  18. doi request reprint 11C-metomidate positron emission tomography after dexamethasone suppression for detection of small adrenocortical adenomas in primary aldosteronism
    J Hennings
    Department of Surgical Sciences, Uppsala University, SE 751 85 Uppsala, Sweden
    Langenbecks Arch Surg 395:963-7. 2010
    ..To evaluate whether dexamethasone suppression treatment can improve (11) C-metomidate positron emission tomography (MTO-PET) detection of small adrenocortical adenomas in primary aldosteronism (PA)...
  19. ncbi request reprint Serum calcium is independently associated with insulin sensitivity measured with euglycaemic-hyperinsulinaemic clamp in a community-based cohort
    E Hagstrom
    Department of Surgical Sciences, Uppsala University, SE 751 85, Uppsala, Sweden
    Diabetologia 50:317-24. 2007
    ..Relatively little is known about the relationship between serum calcium concentration and the underlying causes of diabetes-insulin resistance and defective insulin secretion-in the normocalcaemic general population...
  20. ncbi request reprint Increased 25-hydroxyvitamin D3 1alpha-hydroxylase and reduced 25-hydroxyvitamin D3 24-hydroxylase expression in parathyroid tumors--new prospects for treatment of hyperparathyroidism with vitamin d
    Pamela Correa
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    J Clin Endocrinol Metab 87:5826-9. 2002
    ..These findings should be considered in future development of vitamin D analogues for treatment of HPT...
  21. doi request reprint Surgery and radiofrequency ablation for treatment of liver metastases from midgut and foregut carcinoids and endocrine pancreatic tumors
    John Eriksson
    Department of Surgery, University Hospital, SE 751 85 Uppsala, Sweden
    World J Surg 32:930-8. 2008
    ..However, it is not clear whether such therapy will provide symptom reduction or increased survival...
  22. ncbi request reprint Surgery on neuroendocrine tumours
    Goran Akerstrom
    Department of Surgical Sciences, University Hospital, SE 751 85 Uppsala, Sweden
    Best Pract Res Clin Endocrinol Metab 21:87-109. 2007
    ..Other tumours--glucagonoma, VIPoma, and non-functioning endocrine pancreatic tumours--are often large or metastasizing, but generally require surgical debulking to alleviate hormonal symptoms and have favourable survival...
  23. ncbi request reprint Potentiating effects of nonactive/active vitamin D analogues and ketoconazole in parathyroid cells
    Ulrika Segersten
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Sweden
    Clin Endocrinol (Oxf) 66:399-404. 2007
    ..The aim of this study was to investigate biological effects of a non-1alpha-hydroxylated vitamin D analogue in normal and tumour parathyroid cells...
  24. ncbi request reprint Metabolic abnormalities in patients with normocalcemic hyperparathyroidism detected at a population-based screening
    Emil Hagström
    Endocrine Unit, Department of Surgical Sciences, Uppsala University, University Hospital, SE 751 85 Uppsala, Sweden
    Eur J Endocrinol 155:33-9. 2006
    ....
  25. pmc 25-Hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-1alpha-hydroxylated vitamin D analogue
    Ulrika Segersten
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Breast Cancer Res 7:R980-6. 2005
    ..In addition, expression of the 25-hydroxyvitamin D3 24-hydroxylase (24-hydroxylase) and the vitamin D receptor (VDR) was investigated...
  26. ncbi request reprint Pancreatic tumours as part of the MEN-1 syndrome
    Goran Akerstrom
    Department of Surgical Sciences, University Hospital, SE 751 85 Uppsala, Sweden
    Best Pract Res Clin Gastroenterol 19:819-30. 2005
    ..This strategy with early and aggressive surgery is believed to reduce the risks for malignant progression...
  27. ncbi request reprint Midgut carcinoid tumours: surgical treatment and prognosis
    Göran Kerström
    Department of Surgery, University Hospital, S 751 85 Uppsala, Sweden
    Best Pract Res Clin Gastroenterol 19:717-28. 2005
    ..Favourable survival and appreciable quality of life can be expected with this combined treatment, even in patients with advanced midgut carcinoids...
  28. ncbi request reprint Parathyroidectomy in familial hypercalcemia with clinical characteristics of primary hyperparathyroidism and familial hypocalciuric hypercalcemia
    Eva Szabo
    Department of Surgical Sciences, Endocrine Unit, University Hospital, Uppsala, Sweden
    Surgery 131:257-63. 2002
    ..This study describes parathyroidectomy in a kindred with hypercalcemia due to a heterozygous point mutation in the calcium receptor gene...
  29. ncbi request reprint Primary hyperparathyroidism
    Goran Akerstrom
    Department of Surgery, University Hospital, Uppsala, Sweden
    Curr Opin Oncol 16:1-7. 2004
    ..This contribution presents research progress concerning primary hyperparathyroidism (pHPT), and the background for recent notable changes in treatment policy...
  30. ncbi request reprint 25-hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glands
    Ulrika Segersten
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    J Clin Endocrinol Metab 87:2967-72. 2002
    ..The findings imply that in addition to feedback control by circulating 1,25(OH)(2)D(3) levels, parathyroid cells may also be influenced by local 1alpha -hydroxylase activity with possible growth regulatory and differentiating effects...
  31. ncbi request reprint Surgical treatment of endocrine pancreatic tumours
    Goran Akerstrom
    Department of Surgery, University Hospital, Uppsala, Sweden
    Neuroendocrinology 80:62-6. 2004
    ..It has become obvious that surgical treatment of these tumours is of increased concern and can have a marked impact on symptoms and survival...
  32. ncbi request reprint Long-term survival of patients with small intestinal carcinoid tumors
    Niklas Zar
    Department of Surgery, Ryhov County Hospital, SE 551 85 Jonkoping, Sweden
    World J Surg 28:1163-8. 2004
    ..The divergence between cause-specific and relative survival implies the need for a more detailed analysis of the causes of death of these patients...
  33. ncbi request reprint Management of midgut carcinoids
    Goran Akerstrom
    Department of Surgery, University Hospital, Uppsala, Sweden
    J Surg Oncol 89:161-9. 2005
    ..Favourable survival and life-quality can be expected with this treatment also in patients with advanced midgut carcinoids...
  34. ncbi request reprint Parathyroid glands in calcium regulation and human disease
    Goran Akerstrom
    Department of Surgical Sciences, University Hospital, Uppsala, Sweden
    Ann N Y Acad Sci 1040:53-8. 2005
    ..Newly developed vitamin D analogues with reduced calcemic effects and with more pronounced antiproliferative effect may provide new favorable treatment for reversal of HPT...
  35. ncbi request reprint Culture of parathyroid cells
    Per Hellman
    Department of Surgery, University Hospital, Uppsala, Sweden
    Methods Mol Med 107:291-301. 2005
  36. ncbi request reprint Malignant insulinoma in ectopic pancreatic tissue
    Joakim Hennings
    Department of Surgery, Uppsala University Hospital, Uppsala, Sweden
    Dig Surg 22:377-9. 2005
    ..Both ectopic pancreatic tissue and malignant insulinoma are rare. We encountered the combination of these rare entities in a patient demonstrating hypoglycemic symptoms...
  37. ncbi request reprint [A case report. FDG-PET in occult breast cancer]
    Sam Ladjevardi
    Kirurgiska kliniken, Akademiska sjukhuset, Uppsala
    Lakartidningen 99:524-6. 2002
  38. doi request reprint Risk of second primary malignancies and causes of death in patients with adenocarcinoma and carcinoid of the small intestine
    Niklas Zar
    Department of Surgery, Ryhov County Hospital, Jonkoping, Sweden
    Eur J Cancer 44:718-25. 2008
    ..A detailed analysis of causes of death in a population-based cohort of small intestinal malignancies has not been presented before in the literature...
  39. ncbi request reprint Normalized dyslipidaemia after parathyroidectomy in mild primary hyperparathyroidism: population-based study over five years
    Emil Hagström
    Department of Surgery, Uppsala University Hospital and AstraZeneca R and D, Molndal, Sweden
    Clin Endocrinol (Oxf) 56:253-60. 2002
    ..Secondary dyslipidaemia in pHPT has attracted little attention, although morbidity and mortality associated with cardiovascular diseases have been reported to be increased in these patients...
  40. ncbi request reprint Vitamin D3 polyunsaturated side-chain analogues (EB1089, GS1590) and the 20-epi-vitamin D3 analogue CB1393 suppress parathyroid hormone secretion and mRNA level in bovine parathyroid cells
    Ulrika Segersten
    Department of Surgical Sciences, Uppsala University Hospital, Klinisk forskningsavdelning 2, Ingang 70, plan 3, Lab 9, SE 751 85 Uppsala, Sweden
    J Steroid Biochem Mol Biol 88:289-94. 2004
    ..We conclude that the vitamin D analogues EB1089, GS1590 and CB1393 may be suitable for treatment of hyperparathyroidism secondary to uremia and that further evaluation in vivo should be considered...