Research Topics
Species | J EngellauSummaryAffiliation: University Hospital Country: Sweden Publications
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Publications
Identification of low-risk tumours in histological high-grade soft tissue sarcomasJ Engellau
Department of Oncology, Lund University Hospital, SE 221 85 Lund, Sweden
Eur J Cancer 43:1927-34. 2007..15. The model was validated in an independent material of 175 patients. This model improved prognostication in STS and is of value for identifying patients who probably should not receive adjuvant chemotherapy...
Tissue microarray technique in soft tissue sarcoma: immunohistochemical Ki-67 expression in malignant fibrous histiocytomaJ Engellau
Department of Oncology, Lund University Hospital, Sweden
Appl Immunohistochem Mol Morphol 9:358-63. 2001..The feasibility of tissue microarray for immunohistochemical studies of soft tissue sarcomas offers new possibilities to study multiple markers in large tumor materials...
Time dependence of prognostic factors for patients with soft tissue sarcoma: a Scandinavian Sarcoma Group Study of 338 malignant fibrous histiocytomasJacob Engellau
Department of Oncology, The Jubileum Institute, Lund University, Lund, Sweden
Cancer 100:2233-9. 2004..Prognostic factors for metastasis in soft tissue sarcoma govern decisions regarding adjuvant treatment. However, the significance of initial tumor-related prognostic factors over time is largely unknown...
Improved prognostication in soft tissue sarcoma: independent information from vascular invasion, necrosis, growth pattern, and immunostaining using whole-tumor sections and tissue microarraysJacob Engellau
Department of Oncology, Lund University Hospital, SE 221 85 Lund, Sweden
Hum Pathol 36:994-1002. 2005....
Expression profiling using tissue microarray in 211 malignant fibrous histiocytomas confirms the prognostic value of Ki-67Jacob Engellau
Department of Oncology, Jubileum Institution, Lund University, 22185 Lund, Sweden
Virchows Arch 445:224-30. 2004..Hence, we suggest that proliferation, as measured by Ki-67 index, should be considered as a prognostic marker in clinical management of pleomorphic soft tissue sarcomas...
Prognostic factors in soft tissue sarcoma. Tissue microarray for immunostaining, the importance of whole-tumor sections and time-dependenceJacob Engellau
Department of Oncology, Lund University Hospital, Lund University, Sweden
Acta Orthop Scand Suppl 75:2 p preceding table of contents-52, backcover. 2004..4) were independent prognostic factors. Finally, prognostic factors were found to be time-dependent, and most had lost their prognostic value after 2 years, whereas LR was a strong prognostic factor for metastasis whenever it occurred...
Experiences from tissue microarray in soft tissue sarcomasM Nilbert
Dept of Oncology, University Hospital, Lund, Sweden
Acta Orthop Scand Suppl 75:29-34. 2004..We review the TMA method, its reproducibility, advantages, limitations and future perspectives with specific focus on soft tissue sarcomas...
Increased risk of malignancies in a population-based study of 818 soft-tissue sarcoma patientsJ Fernebro
Department of Oncology, Institute of Clinical Sciences, Lund University Hospital, Lund, Sweden
Br J Cancer 95:986-90. 2006..6; 95% CI=8.1-33.5; P<0.001). Hence, this population-based series demonstrates a high frequency of second primary tumours among STS patients and indicates a particularly increased risk of developing a new STS...
Fine-needle aspiration of neurilemoma (schwannoma). A clinicocytopathologic study of 116 patientsHenryk A Domanski
Department of Pathology and Cytology, Lund University Hospital, Lund, Sweden
Diagn Cytopathol 34:403-12. 2006..Furthermore aspirates showing predominantly Antoni A features, nuclear pleomorphism, and/or myxoid changes can easily be confused with other types of benign or malignant soft-tissue tumors...
Standardizing evaluation of sarcoma proliferation- higher Ki-67 expression in the tumor periphery than the centerJosefin Fernebro
Department of Oncology, Institute of Clinical Sciences, Lund University Hospital, Lund, Sweden
APMIS 115:707-12. 2007..Our findings suggest that the determination of proliferation in soft tissue sarcomas should be standardized for clinical application of Ki-67 as a prognostic marker...
Core-needle biopsy performed by the cytopathologist: a technique to complement fine-needle aspiration of soft tissue and bone lesionsHenryk A Domanski
Department of Pathology and Cytology, Lund University Hospital, Lund, Sweden
Cancer 105:229-39. 2005..The main limitation of FNAC of soft tissue and bone neoplasms is in the evaluation of tissue architecture. In addition cytologic specimens are not always adequate for ancillary studies...
Molecular cytogenetic characterization of an ins(4;X) occurring as the sole abnormality in an aggressive, poorly differentiated soft tissue sarcomaCecilia Surace
Department of Clinical Genetics, Lund University Hospital, SE-221 85, Lund, Sweden
Virchows Arch 447:869-74. 2005..Our results suggest that BCOR and/or an ECM-like protein could be involved in the pathogenesis of a subgroup of PNET or PNET-like sarcomas...
