Research Topics
Species | K AsplundSummaryAffiliation: University Hospital Country: Sweden Publications
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Publications
Linkage of ischemic stroke to the PDE4D region on 5q in a Swedish populationSofie Nilsson-Ardnor
Department of Medical Biosciences, Umea University, SE 901 87, Umea, Sweden
Stroke 36:1666-71. 2005..Using a candidate region approach, we wanted to test the validity of these findings in a different population from northern Sweden...
The role of the data safety and monitoring committee in stroke trialsKjell Asplund
Department of Medicine, University Hospital, SE 901 85 Umea, Sweden
Eur Neurol 49:115-9. 2003..The DSMC provides recommendations to the steering committee of the trial on whether to continue or to stop patient recruitment and on protocol amendments that may be necessary to protect the safety of the patients...
Stroke care in the UK--is it good enough?Kjell Asplund
Department of Medicine, University Hospital, Umea, Sweden
Lancet Neurol 1:341. 2002
Health care resource use and stroke outcome. Multinational comparisons within the GAIN International trialKjell Asplund
Department of Medicine, University Hospital, Umea, Sweden
Int J Technol Assess Health Care 19:267-77. 2003....
Smokeless tobacco as a possible risk factor for stroke in men: a nested case-control studyKjell Asplund
Medicine and Epidemiology, Department of Public Health and Clinical Medicine, University Hospital, Umea, Sweden
Stroke 34:1754-9. 2003..The purpose of this study was to explore whether the use of snuff, a smokeless tobacco product, increases the risk of stroke in men...
[Use of snuff entails lower risk of cardiovascular diseases than does smoking]Kjell Asplund
Medicinkliniken, Norrlands Universitetssjukhus, Umea
Lakartidningen 100:2206-10. 2003..It is concluded that the use of smokeless tobacco (with snuff being the most studied variant) entails a lower risk of adverse cardiovascular effects than does smoking...
[Snuff is less dangerous than smoking for the cardiovascular system. Wrong to hide the scientific basis which does not confirm the hypothesis]Kjell Asplund
Norrlands Universitetssjukhus, Ume
Lakartidningen 100:2392-3. 2003
Antioxidant vitamins in the prevention of cardiovascular disease: a systematic reviewK Asplund
Department of Medicine, University Hospital, Umeå and Swedish Council for Technology Assessment in Health Care, Stockholm, Sweden
J Intern Med 251:372-92. 2002..Antioxidant vitamins as food supplements cannot be recommended in the primary or secondary prevention against cardiovascular disease...
Smokeless tobacco and cardiovascular diseaseKjell Asplund
Department of Medicine, University Hospital, Umea, Sweden
Prog Cardiovasc Dis 45:383-94. 2003..Whether or not the apparent risk reduction is a useful strategy to help inveterate smokers to quit is a matter of debate, as are the public health effects of a high prevalence of snuff use in some populations...
Riks-stroke - a Swedish national quality register for stroke careKjell Asplund
Department of Medicine, University Hospital, Umea, Sweden
Cerebrovasc Dis 15:5-7. 2003..Riks-Stroke, the Swedish national quality register on stroke care, provides unique opportunities to evaluate stroke units in routine clinical care...
[Methadone and naltrexone in heroin addiction--an explanation from the SBU]Kjell Asplund
Lakartidningen 99:552-3. 2002
Stroke units in their natural habitat: can results of randomized trials be reproduced in routine clinical practice? Riks-Stroke CollaborationB Stegmayr
Department of Medicine, University Hospital, Umea, Sweden
Stroke 30:709-14. 1999..This study examined whether these results can be reproduced in clinical practice...
[Stroke unit care saves lives. The Swedish national quality assessment registry of stroke care is the first of its kind in the world]B Stegmayr
Medicinska institutionen, Norrlands Universitetssjukhus, Umea
Lakartidningen 96:2719-24, 2726. 1999..Thus, the promising results of the randomised trials of SU treatment would appear to be reproducible in routine clinical practice, though the beneficial effect is smaller in magnitude...
Does pretreatment with statins improve clinical outcome after stroke? A pilot case-referent studyN Jonsson
Department of Medicine, Umea University, Umea, Sweden
Stroke 32:1112-5. 2001..In a preliminary observational study, we explored whether clinical outcome is improved in patients who are on treatment with statins when stroke occurs...
Time trends in long-term survival after stroke: the Northern Sweden Multinational Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) study, 1985-1994M Peltonen
Department of Medicine, Umea University, Sweden
Stroke 29:1358-65. 1998..Stroke mortality rates and case fatality of stroke have declined since the beginning of the 1970s in Sweden, but the incidence of stroke has been stable. The aim of this study was to analyze trends in long-term survival after stroke...
Influence of smoking and snus on the prevalence and incidence of type 2 diabetes amongst men: the northern Sweden MONICA studyM Eliasson
Department of Medicine, Sunderby Hospital, Lulea, Sweden
J Intern Med 256:101-10. 2004..To explore the effect of smoking and smokeless tobacco, 'snus', on the risk of type 2 diabetes...
Patient dissatisfaction with acute stroke careKjell Asplund
Riks Stroke, Department of Medicine, University Hospital, SE 90185 Umeå, Sweden
Stroke 40:3851-6. 2009..Riks-Stroke, the Swedish Stroke Register, was used to explore patient characteristics and stroke services as determinants of patient dissatisfaction with acute in-hospital care...
Age-period-cohort effects on stroke mortality in Sweden 1969-1993 and forecasts up to the year 2003M Peltonen
Department of Medicine, Umea University, Sweden
Stroke 27:1981-5. 1996..The aim of this study was to analyze mortality rates for stroke in Sweden during the period 1969 through 1993 and to predict mortality trends until the year 2003, taking into account age, cohort, and period effects...
Leptin is associated with increased risk of myocardial infarctionS Soderberg
Department of Medicine, Umea University, Sweden
J Intern Med 246:409-18. 1999..We tested whether leptin is a risk factor for acute myocardial infarction (AMI) in a nested case-referent study...
Can a sustainable community intervention reduce the health gap?--10-year evaluation of a Swedish community intervention program for the prevention of cardiovascular diseaseL Weinehall
Department of Public Health and Clinical Medicine, Umea University, Sweden
Scand J Public Health Suppl 56:59-68. 2001..This paper evaluates the 10-year outcomes of a Northern Sweden community intervention program for the prevention of cardiovascular disease (CVD), with special reference to the social patterning of risk development...
Screening for impaired glucose tolerance. Results from a population-based study in 21,057 individualsB Lindahl
Department of Public Health and Clinical Medicine, Umea University, Sweden
Diabetes Care 22:1988-92. 1999..The study focuses especially on the relation to age, obesity, and heredity background of diabetes...
Cognitive-behavioural stress management does not improve biological cardiovascular risk indicators in women with ischaemic heart disease: a randomized-controlled trialM Claesson
Department of Public Health and Clinical Medicine Medicine, Umea University Hospital, Umea, Sweden
J Intern Med 260:320-31. 2006..In the present study, we tested the hypothesis that the improvement in psychosocial well-being is associated with an improvement in biochemical indicators of cardiovascular risk...
Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose toleranceB Lindahl
Department of Nutritional Research, Umea University, Sweden
J Intern Med 246:105-12. 1999..To assess the effects of lifestyle intervention on cardiovascular risk factors in general and especially on fibrinolysis...
[Improved survival after stroke but unchanged risk of incidence]Birgitta Stegmayr
Institutionen för folkhälsa och klinisk medicin, Norrlands Universitetssjukhus, Umea
Lakartidningen 100:3492-8. 2003..Therefore, it is very important to reduce or eliminate risk factors for stroke. Preventing a stroke saves much suffering for both patients and relatives and reduces the economic burden for the society...
Declining mortality from subarachnoid hemorrhage: changes in incidence and case fatality from 1985 through 2000Birgitta Stegmayr
Department Public Health and Clinical Medicine, Umea University Hospital, SE 901 85 Umea, Sweden
Stroke 35:2059-63. 2004..In this study, trends in incidence, 28-day case fatality (CF), and mortality in SAH were followed over a 16-year period...
Discarding heparins as treatment for progressive stroke in Sweden 2001 to 2008Marie Eriksson
Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden
Stroke 41:2552-8. 2010..We studied how heparin treatment for progressive stroke has been discarded in Sweden...
Sex differences in management and outcome after stroke: a Swedish national perspectiveEva Lotta Glader
Department of Public Health and Clinical Medicine, University Hospital Umea, S 901 95 Umeå, Sweden
Stroke 34:1970-5. 2003..The objective of this study was to verify and explain differences between men and women in management and outcome after stroke in a national perspective...
Women's hearts--stress management for women with ischemic heart disease: explanatory analyses of a randomized controlled trialMaria Claesson
Department of Public Health, University Hospital, Umea, Sweden
J Cardiopulm Rehabil 25:93-102. 2005..This randomized controlled study aimed to evaluate the effects on psychosocial variables of a 1-year group-based cognitive-behavioral stress management program developed specifically for women with ischemic heart disease...
Dissemination of thrombolysis for acute ischemic stroke across a nation: experiences from the Swedish stroke register, 2003 to 2008Marie Eriksson
Department of Public Health and Clinical Medicine, Division of Medicine, Umea University, 901 87 Umea, Sweden
Stroke 41:1115-22. 2010..We used Riks-Stroke, the Swedish Stroke Register, to explore how thrombolysis has been disseminated in Swedish hospitals since it was approved in 2003...
Poststroke fatigue: a 2-year follow-up study of stroke patients in SwedenEva Lotta Glader
Department of Public Health and Clinical Medicine, University Hospital, Umea, Sweden
Stroke 33:1327-33. 2002..Fatigue is common among stroke patients. This study determined the prevalence of fatigue among long-term survivors after stroke and what impact fatigue had on various aspects of daily life and on survival...
Informed consent for genetic research on blood stored for more than a decade: a population based studyBirgitta Stegmayr
Department of Public Health and Clinical Medicine, , Ume, S-901 85, Sweden
BMJ 325:634-5. 2002
Self-reported depression and use of antidepressants after stroke: a national surveyMarie Eriksson
Department of Public Health and Clinical Medicine, Umea University, Sweden
Stroke 35:936-41. 2004..Depression after stroke is often described as underdiagnosed and undertreated. However, there are few data on self-reported depression and use of antidepressants in stroke patients at large. Materials and..
[Genetic research on blood samples stored for years in biobanks. Most people are willing to provide informed consent]Birgitta Stegmayr
Institutionen för folkhälsa och klinisk medicin, Norrlands Universitetssjukhus, Umea
Lakartidningen 100:618-20. 2003..3%) wanted to be informed and give their concent to every new specific project. All the others gave a general concent provided that an Ethics Committee had approved the research...
Plasminogen activator inhibitor-1 4G/5G polymorphism and risk of stroke: replicated findings in two nested case-control studies based on independent cohortsPer Gunnar Wiklund
Department of Public Health and Clinical Medicine, Umea University Hospital, Sweden
Stroke 36:1661-5. 2005..The aim of this study was to investigate the common functional 4/5 guanosine (4G/5G) polymorphism in the promoter region of the PAI-1 gene and the risk of stroke...
Use of complementary and alternative medicine remedies in Sweden. A population-based longitudinal study within the northern Sweden MONICA Project. Multinational Monitoring of Trends and Determinants of Cardiovascular DiseaseM Nilsson
Department of Public Health and Clinical Medicine, University Hospital, , Sweden
J Intern Med 250:225-33. 2001..It has been increasing during the 1990s. Its use is particularly common in women, well-educated people and in those with poor self-perceived health...
Stroke in Northern SwedenBirgitta Stegmayr
Medicine, Department of Public Health and Clinical Medicine Umeå University, Umea, Sweden
Scand J Public Health Suppl 61:60-9. 2003..The WHO initiated, 20 years ago, the MONICA Project. The aim of the study was to measure trends in coronary heart disease and stroke and to assess the extent to which these were related to changes in known risk factors...
Relative risks for stroke by age, sex, and population based on follow-up of 18 European populations in the MORGAM ProjectKjell Asplund
Department of Public Health and Clinical Medicine, Umea University Hospital, Umea, Sweden
Stroke 40:2319-26. 2009..Within the framework of the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project, the variations in impact of classical risk factors of stroke by population, sex, and age were analyzed...
Psychosocial distress and impaired quality of life--targets neglected in the secondary prevention in women with ischaemic heart diseaseMaria Claesson
Medicine, Department of Public Health and Clinical Medicine, University Hospital, Ume, Sweden
Eur J Cardiovasc Prev Rehabil 10:258-66. 2003..Secondary prevention by psychosocial intervention in women with IHD should be evaluated in randomized controlled trials...
Widening gap of stroke between east and west. Eight-year trends in occurrence and risk factors in Russia and SwedenB Stegmayr
Department of Medicine, Umea University, Sweden
Stroke 31:2-8. 2000..The aim of this study was to investigate trends in stroke attack rates and 28-day case fatality and risk factor levels in Novosibirsk, Siberia, and northern Sweden during 1987-1994...
1999 WHO/ISH Guidelines applied to a 1999 MONICA sample from northern SwedenMats Persson
Family Medicine, Department of Public Health and Clinical Medicine, 901 87 University of Umeå, Sweden
J Hypertens 20:29-35. 2002..WHO/ISH Hypertension Guidelines from 1999 propose a risk stratification for estimating absolute risk for CVD based on blood pressure and additional risk factors, target organ damage (TOD) and CVD...
[Stroke--risk factors and primary prevention]Kjell Asplund
Medicinska kliniken, Norrlands Universitetssjukhus, Ume
Lakartidningen 100:3500-5. 2003..Antismoking advice and anticoagulants in patients with atrial fibrillation and other cardiac sources of embolism also have favourable effects relative to costs. There is a dearth of successful population-based programs to prevent stroke...
What MONICA told us about strokeKjell Asplund
National Board of Health and Welfare and the Department of Medicine, University Hospital, Umea, Sweden
Lancet Neurol 4:64-8. 2005....
Beyond conventional stroke guidelines: setting prioritiesBo Norrving
Department of Neurology, University Hospital, Lund, Sweden
Stroke 38:2185-90. 2007..An open and translucent priority-setting procedure would benefit patients, professionals, and decision-makers. Prioritization is an innovative part of the new Swedish national stroke guidelines...
The Northern Sweden MONICA project: concluding remarksKjell Asplund
Medicine, , Ume, Sweden
Scand J Public Health Suppl 61:78-84. 2003
Mishaps in the management of stroke: a review of 214 complaints to a medical responsibility boardAsa Johansson
Medicine, Department of Public Health and Clinical Medicine, University Hospital, Northern Branch, Ume, Sweden
Cerebrovasc Dis 18:16-21. 2004..The small number of formal complaints and disciplinary actions suggest that other, blameless procedures have a greater potential than MRB actions to reduce mishaps in routine stroke care...
The impact of nurses' opinion of client behaviour and level of social functioning on the amount of time they spend with clientsL Kristiansen
Department of Health Sciences, Mid Sweden University, Sundsvall, Karolinska Institutet, Stockholm, Sweden
J Psychiatr Ment Health Nurs 12:719-27. 2005..4%). It might be possible to interpret the results of this study in the light of a process of dehumanization...
Exploring sex differences in case fatality in acute myocardial infarction or coronary death events in the northern Sweden MONICA ProjectV Lundberg
Department of Medicine, Kalix Hospital, Sweden
J Intern Med 251:235-44. 2002..To investigate sex differences in reaching diagnosis, medical management and case fatality (CF) in acute myocardial infarction (AMI) in the population aged 35-64 years in northern Sweden...
Large variations in the use of oral anticoagulants in stroke patients with atrial fibrillation: a Swedish national perspectiveE L Glader
Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden
J Intern Med 255:22-32. 2004..To explore nation-wide use of anticoagulation in stroke patients with atrial fibrillation, in routine clinical practice in Sweden...
[Evidence-based medicine--a new course in medical education]Kjell Asplund
Medicinska kliniken, Norrlands Universitetssjukhus, Ume
Lakartidningen 99:2176-7. 2002
Electrocardiographic changes in patients with acute stroke: a systematic reviewGeorge Khechinashvili
Department of Medicine, University Hospital, Umea, Sweden
Cerebrovasc Dis 14:67-76. 2002..The specificity of ECG changes to diagnose acute myocardial infarction is low in the acute phase of stroke...
Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability studyAlida A Gouw
Department of Neurology, Alzheimer Center and Image Analysis Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Stroke 39:1414-20. 2008..We studied the natural course of white matter hyperintensities (WMH) and lacunes, the main MRI representatives of small vessel disease, over time and evaluated possible predictors for their development...
Do trends in population levels of blood pressure and other cardiovascular risk factors explain trends in stroke event rates? Comparisons of 15 populations in 9 countries within the WHO MONICA Stroke Project. World Health Organization Monitoring of Trends Hanna Tolonen
Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
Stroke 33:2367-75. 2002..To what extent variations in stroke trends between populations can be attributed to differences in classic cardiovascular risk factor trends is unknown...
Genome-wide linkage scan of common stroke in families from northern SwedenSofie Nilsson Ardnor
Department of Medical Biosciences, Division of Medical and Clinical Genetics, Umea University, 901 85 Umea, Sweden
Stroke 38:34-40. 2007..Taking advantage of low genetic variations in northern Sweden, we performed a genome-wide linkage scan to investigate the susceptibility loci for common forms of stroke...
[What the MONICA project has taught us about cardiovascular diseases--society, public health and health care]Kjell Asplund
Socialstyrelsen, Stockholm
Lakartidningen 103:3006-11. 2006
European joint assessments and coordination of findings and resources. Working group 3 reportM Dolors Estrada
Norrlands University Hospital The Swedish Council on Technology Assessment in Health Care (SBU, Sweden
Int J Technol Assess Health Care 18:321-60. 2002
Trends in stroke and coronary heart disease in the WHO MONICA ProjectThomas Truelsen
World Health Organization Noncommunicable Diseases and Mental Health Cross Cluster Surveillance, CH 1211 Geneva 27, Switzerland
Stroke 34:1346-52. 2003..Because they share major common risk factors, it would be expected that trends in mortality and incidence of these 2 major cardiovascular diseases would be similar...
MORGAM (an international pooling of cardiovascular cohorts)Alun Evans
Department of Epidemiology and Public Health, Mulhouse Building, Queen's University Belfast, Belfast BT12 6BJ, N. Ireland, UK
Int J Epidemiol 34:21-7. 2005
UK-279,276, a neutrophil inhibitory glycoprotein, in acute stroke: tolerability and pharmacokineticsKennedy R Lees
University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, G11 6NT, UK
Stroke 34:1704-9. 2003..The purposes of this study were to evaluate the safety and tolerability of UK-279,276 and to examine its pharmacokinetics and pharmacodynamics (binding to neutrophil CD11b) in patients with acute stroke...
Are changes in mortality from stroke caused by changes in stroke event rates or case fatality? Results from the WHO MONICA ProjectCinzia Sarti
Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
Stroke 34:1833-40. 2003....
Use of oral contraceptives and hormone replacement therapy in the WHO MONICA projectVivan Lundberg
Department of Internal Medicine, Kalix Hospital, Kalix, Sweden
Maturitas 48:39-49. 2004..To compare menopausal age and the use of oral contraceptives (OC) and hormonal replacement therapy (HRT) between the 32 populations of the WHO MONICA Project, representing 20 different countries...
Impact of age-related cerebral white matter changes on the transition to disability -- the LADIS study: rationale, design and methodologyLeonardo Pantoni
Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
Neuroepidemiology 24:51-62. 2005..The study results may also help to standardize, on an international basis, tools and criteria to identify early stages of disability...
Findings from the reanalysis of the NINDS tissue plasminogen activator for acute ischemic stroke treatment trialTimothy John Ingall
Department of Neurology, Mayo Clinic Scottsdale, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
Stroke 35:2418-24. 2004..quot;..
Population effects on individual systolic blood pressure: a multilevel analysis of the World Health Organization MONICA ProjectJuan Merlo
Department of Community Medicine, Section of Preventive Medicine, Lund University, Malmo, Sweden
Am J Epidemiol 159:1168-79. 2004..This empirical evidence of a population effect on individual SBP emphasizes the importance of developing population-wide strategies to reduce individual risk of hypertension...
[Two years with EBM in Lakartidningen. Clinical research and routine health care closer to each other]Lars Werko
Statens beredning för medicinsk utvärdering SBU, Stockholm
Lakartidningen 99:3478-9, 3482. 2002
Editorial comment--Down with the class society!Kjell Asplund
Stroke 34:2628-9. 2003
Reliability and sensitivity of visual scales versus volumetry for evaluating white matter hyperintensity progressionA A Gouw
Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
Cerebrovasc Dis 25:247-53. 2008..However, the most suitable method for measuring WMH progression has not been established yet. We compared the reliability and sensitivity of cross-sectional and longitudinal visual scales with volumetry for measuring WMH progression...
The events registration and survey procedures in the Northern Sweden MONICA ProjectBirgitta Stegmayr
Medicine, Department of Public Health and Clinical Medicine Umeå University Umeå, Sweden
Scand J Public Health Suppl 61:9-17. 2003..In most MONICA populations, the study has covered a period of 10 years or more...
[How the SBU influenced clinical practice. Consequences of seven reports scrutinized]Mona Britton
Karolinska Institutet,
Lakartidningen 99:4628-9, 4632-4. 2002
Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) StudyAnna Maria Basile
Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy, and Department of Neurology, , Paris, France
Cerebrovasc Dis 21:315-22. 2006..CONCLUSIONS: The LADIS Study confirms that age, hypertension and lacunar strokes are the major determinants of ARWMC. Smoking and hypercholesterolemia provide additional risk...
The CTLA4 region as a general autoimmunity factor: an extended pedigree provides evidence for synergy with the HLA locus in the etiology of type 1 diabetes mellitus, Hashimoto's thyroiditis and Graves' diseaseElisabet Einarsdottir
, , Sweden
Eur J Hum Genet 11:81-4. 2003....
[Potential donor/real donor--the gap is big. Organ procurement activities at Swedish hospitals must be quality assured]Håkan Gäbel
Lakartidningen 101:342-3. 2004
