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Genomes and Genes | Goran AkerstromSummaryAffiliation: University Hospital Country: Sweden Publications
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Publications
Surgical treatment of endocrine pancreatic tumoursGoran Akerstrom
Department of Surgery, University Hospital, Uppsala, Sweden
Neuroendocrinology 80:62-6. 2004..It has become obvious that surgical treatment of these tumours is of increased concern and can have a marked impact on symptoms and survival...- Timing and extent of surgery in symptomatic and asymptomatic neuroendocrine tumors of the pancreas in MEN 1Goran Akerstrom
Department of Surgical Sciences, University Hospital, 75185 Uppsala, Sweden
Langenbecks Arch Surg 386:558-69. 2002..More extensive surgical tumor reduction is believed to reduce the risks for malignant progression of the pancreaticoduodenal tumors, but this requires further evaluation in MEN 1... - Pancreatic tumours as part of the MEN-1 syndromeGoran Akerstrom
Department of Surgical Sciences, University Hospital, SE 751 85 Uppsala, Sweden
Best Pract Res Clin Gastroenterol 19:819-30. 2005..This strategy with early and aggressive surgery is believed to reduce the risks for malignant progression... - Parathyroid glands in calcium regulation and human diseaseGoran Akerstrom
Department of Surgical Sciences, University Hospital, Uppsala, Sweden
Ann N Y Acad Sci 1040:53-8. 2005..Newly developed vitamin D analogues with reduced calcemic effects and with more pronounced antiproliferative effect may provide new favorable treatment for reversal of HPT... - Primary hyperparathyroidismGoran Akerstrom
Department of Surgery, University Hospital, Uppsala, Sweden
Curr Opin Oncol 16:1-7. 2004..This contribution presents research progress concerning primary hyperparathyroidism (pHPT), and the background for recent notable changes in treatment policy... 
Long-term results of surgery for small intestinal neuroendocrine tumors at a tertiary referral centerOlov Norlén
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
World J Surg 36:1419-31. 2012..Our aim was to identify prognostic factors for survival and to evaluate outcome after surgery in SI-NET patients...- Potentiating effects of nonactive/active vitamin D analogues and ketoconazole in parathyroid cellsUlrika Segersten
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Sweden
Clin Endocrinol (Oxf) 66:399-404. 2007..The aim of this study was to investigate biological effects of a non-1alpha-hydroxylated vitamin D analogue in normal and tumour parathyroid cells... - Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipientsTijana Krajisnik
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Kidney Int 78:1024-32. 2010..Thus parathyroid Klotho and FGFR1 decrease with declining renal function, possibly because of alterations in mineral metabolism related to the failing kidney. This could explain the observed parathyroid resistance to FGF23 in late CKD... - Increased 25-hydroxyvitamin D3 1alpha-hydroxylase and reduced 25-hydroxyvitamin D3 24-hydroxylase expression in parathyroid tumors--new prospects for treatment of hyperparathyroidism with vitamin dPamela Correa
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE-751 85 Uppsala, Sweden
J Clin Endocrinol Metab 87:5826-9. 2002..These findings should be considered in future development of vitamin D analogues for treatment of HPT... - Surgery on neuroendocrine tumoursGoran Akerstrom
Department of Surgical Sciences, University Hospital, SE 751 85 Uppsala, Sweden
Best Pract Res Clin Endocrinol Metab 21:87-109. 2007..Other tumours--glucagonoma, VIPoma, and non-functioning endocrine pancreatic tumours--are often large or metastasizing, but generally require surgical debulking to alleviate hormonal symptoms and have favourable survival... - Surgery and radiofrequency ablation for treatment of liver metastases from midgut and foregut carcinoids and endocrine pancreatic tumorsJohn Eriksson
Department of Surgery, University Hospital, SE 751 85 Uppsala, Sweden
World J Surg 32:930-8. 2008..However, it is not clear whether such therapy will provide symptom reduction or increased survival... 
Stabilizing mutation of CTNNB1/beta-catenin and protein accumulation analyzed in a large series of parathyroid tumors of Swedish patientsPeyman Björklund
Department of Surgical Sciences, Endocrine Unit, Uppsala University, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
Mol Cancer 7:53. 2008..The aim of the present study was to determine the frequency and zygosity of mutations in CTNNB1 exon 3, and beta-catenin accumulation in a large series of parathyroid adenomas of Swedish patients...- Management of midgut carcinoidsGoran Akerstrom
Department of Surgery, University Hospital, Uppsala, Sweden
J Surg Oncol 89:161-9. 2005..Favourable survival and life-quality can be expected with this treatment also in patients with advanced midgut carcinoids... - The internally truncated LRP5 receptor presents a therapeutic target in breast cancerPeyman Björklund
Department of Surgical Sciences, Endocrine Unit, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
PLoS ONE 4:e4243. 2009.... - Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene epigenetically deregulated in hyperparathyroid tumors by histone H3 lysine modificationJessica Svedlund
Department of Surgical Sciences, Uppsala University, Uppsala University Hospital, Entrance 70, Third Floor, SE 75185 Uppsala, Sweden
J Clin Endocrinol Metab 97:E1307-15. 2012..In renal failure, secondary hyperparathyroidism (sHPT) occurs with multiple tumor development as a result of calcium and vitamin D regulatory disturbance... - Type I membrane klotho expression is decreased and inversely correlated to serum calcium in primary hyperparathyroidismPeyman Björklund
Department of Medical Sciences, Uppsala University Hospital, Ing 70, 3 tr, UAS, 75185 Uppsala, Sweden
J Clin Endocrinol Metab 93:4152-7. 2008..In contrast, Klotho inhibits PTH secretion indirectly through the action of fibroblast growth factor-23. Abnormal Klotho expression in parathyroid disorders remains to be elucidated... - Different gene expression profiles in metastasizing midgut carcinoid tumorsKatarina Edfeldt
Department of Surgical Sciences, Uppsala University, SE 751 85 Uppsala, Sweden
Endocr Relat Cancer 18:479-89. 2011..This study reveals differences in gene expression profiles and novel genes that may be of importance in midgut carcinoid tumor progression... - Reduced p18INK4c, p21CIP1/WAF1 and p27KIP1 mRNA levels in tumours of primary and secondary hyperparathyroidismPamela Correa Buchwald
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Uppsala, Sweden
Clin Endocrinol (Oxf) 60:389-93. 2004..Cyclin-dependent kinase inhibitors (CKIs), which generally inhibit cell cycle progression, modulate the activity of cyclin-CDK complexes... 
25-Hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-1alpha-hydroxylated vitamin D analogueUlrika Segersten
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
Breast Cancer Res 7:R980-6. 2005..In addition, expression of the 25-hydroxyvitamin D3 24-hydroxylase (24-hydroxylase) and the vitamin D receptor (VDR) was investigated...- Exclusive underexpression of vitamin D receptor exon 1f transcripts in tumors of primary hyperparathyroidismPamela Correa
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE-751 85 Uppsala, Sweden
Eur J Endocrinol 147:671-5. 2002.... - 25-hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glandsUlrika Segersten
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
J Clin Endocrinol Metab 87:2967-72. 2002..The findings imply that in addition to feedback control by circulating 1,25(OH)(2)D(3) levels, parathyroid cells may also be influenced by local 1alpha -hydroxylase activity with possible growth regulatory and differentiating effects... - Evaluation of CDKN2C/p18, CDKN1B/p27 and CDKN2B/p15 mRNA expression, and CpG methylation status in sporadic and MEN1-associated pancreatic endocrine tumoursDaniel Lindberg
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Uppsala, Sweden
Clin Endocrinol (Oxf) 68:271-7. 2008..Here, we have compared the relative mRNA expression level and CpG methylation status of p18, p27 and p15 in 18 pancreatic endocrine tumours (PETs) with or without MEN1 gene mutations... - Aberrant WNT/β-catenin signaling in parathyroid carcinomaJessica Svedlund
Department of Surgical Sciences, Endocrine Unit, Uppsala University, SE 751 85 Uppsala, Sweden
Mol Cancer 9:294. 2010..The molecular etiology of PC is poorly understood... - Stenting of the superior mesenteric vein in midgut carcinoid disease with large mesenteric massesPer Hellman
Department of Surgery, University of Uppsala, SE 751 85, Uppsala, Sweden
World J Surg 34:1373-9. 2010..These symptoms include severe abdominal pain, attacks of diarrhea, and malnutrition... - Surgical management of MEN-1 and -2: state of the artGoran Akerstrom
Department of Surgery, University Hospital, Uppsala, 751 85 Sweden
Surg Clin North Am 89:1047-68. 2009..Prophylactic thyroidectomy based on DNA testing in the MEN-2 syndrome is considered one of the greater achievements in cancer treatment, because it may be performed before thyroid carcinoma development and provides cure for the patient... - Cyclin-dependent kinase 4 (CDK4) expression in pancreatic endocrine tumorsDaniel Lindberg
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Uppsala, Sweden
Neuroendocrinology 86:112-8. 2007..CDK4 is central to the cell cycle control in pancreatic beta cells, and we have assessed whether CDK4 expression is deregulated in 18 human sporadic or familial PETs... - Underexpression of Gcm2, a master regulatory gene of parathyroid gland development, in adenomas of primary hyperparathyroidismPamela Correa
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Klinisk forskningsavdelning 2, SE 751 85 Uppsala, Sweden
Clin Endocrinol (Oxf) 57:501-5. 2002..Mouse Gcm2 is restricted to parathyroid tissues and Gcm2 was recently identified as a master regulatory gene of parathyroid gland development as Gcm2 knockout mice lack parathyroid glands... - In situ RNA-RNA hybridisation of phospholipase C beta 3 shows lack of expression in neuroendocrine tumoursPeter Stalberg
Department of Surgical Sciences, University Hospital, S 751 85 Uppsala, Sweden
Anticancer Res 23:2227-32. 2003.... - Vitamin D in normal and pathological parathyroid glands: new prospects for treating hyperparathyroidism (review)Pamela Correa Buchwald
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
Int J Mol Med 15:701-6. 2005..The growth-inhibitory properties of 1,25(OH)2D3 are prospects for treatment of hyperparathyroidism... - Mutational analysis of p27 (CDKN1B) and p18 (CDKN2C) in sporadic pancreatic endocrine tumors argues against tumor-suppressor functionDaniel Lindberg
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Uppsala, Sweden
Neoplasia 9:533-5. 2007..Three known polymorphisms were found in the p18 gene. These data suggest that p27 and p18 are unlikely to present classic tumor-suppressor genes in sporadic PETs... - Radiofrequency tissue ablation using cooled tip for liver metastases of endocrine tumorsPer Hellman
Department of Surgery, University Hospital, SE 751 85 Uppsala, Sweden
World J Surg 26:1052-6. 2002..e., no residual macroscopic tumor) in 4 patients. We conclude that RF using cooled-tip needles is safe and efficient; it may be performed percutaneously and intraoperatively; and it may expand the indications for liver resection... - Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumoursDaniel Lindberg
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Uppsala, Sweden
Clin Endocrinol (Oxf) 66:110-4. 2007..We have analysed whether WNT7A or HDAC11 was biallelically inactivated in a group of well-characterized PETs... - Prophylactic cholecystectomy in midgut carcinoid patientsOlov Norlén
Department of Surgery, Uppsala University, SE 751 85, Uppsala, Sweden
World J Surg 34:1361-7. 2010..Prophylactic cholecystectomy has been advocated, but data to support this recommendation are sparse. We have analyzed a cohort of 235 patients with MGC focusing on the risk for gallstone formation and complications thereof... - Multiple endocrine neoplasia type 1 polymorphism D418D is associated with sporadic primary hyperparathyroidismPamela Correa
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Sweden
Surgery 132:450-5. 2002..The multiple endocrine neoplasia type 1 gene is the most commonly deranged gene in parathyroid adenomas and contains several polymorphisms including D418D with a prevalence of roughly 50%... - Accumulation of nonphosphorylated beta-catenin and c-myc in primary and uremic secondary hyperparathyroid tumorsPeyman Björklund
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
J Clin Endocrinol Metab 92:338-44. 2007..In renal failure, secondary hyperparathyroidism (sHPT) occurs with multiple tumor development as a result of calcium and vitamin D regulatory disturbance... - High success rate of parathyroid reoperation may be achieved with improved localization diagnosisOla Hessman
Department of Surgery, University Hospital, 751 85 Uppsala, Swede
World J Surg 32:774-81; discussion 782-3. 2008..We report the use of consistently applied localization diagnosis to yield high success rates in parathyroid reoperations... - An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signalingPeyman Björklund
Department of Surgical Sciences, Uppsala University, Endocrine Unit, Uppsala University Hospital, Uppsala, Sweden
PLoS Med 4:e328. 2007..Mechanisms that may account for this activation have not been identified, except for a few cases of beta-catenin (CTNNB1) stabilizing mutation in pHPT tumors... - Recurrent genomic alterations in benign and malignant pheochromocytomas and paragangliomas revealed by whole-genome array comparative genomic hybridization analysisJohanna Sandgren
Department of Surgical Sciences, Uppsala University Hospital Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
Endocr Relat Cancer 17:561-79. 2010.... - Molecular genetics of parathyroid diseaseGunnar Westin
Department of Surgical Sciences, Uppsala University Hospital, 751 85 Uppsala, Sweden
World J Surg 33:2224-33. 2009..The present contribution summarizes more recent knowledge of parathyroid molecular genetics... - Effect of surgery on the outcome of midgut carcinoid disease with lymph node and liver metastasesPer Hellman
Department of Surgery, University Hospital, SE 751 85 Uppsala, Sweden
World J Surg 26:991-7. 2002..Liver metastases and significant preoperative weight loss are identified as major negative prognostic factors for survival... - Integrative epigenomic and genomic analysis of malignant pheochromocytomaJohanna Sandgren
Department of Surgical Sciences, Uppsala University, Uppsala University Hospital, SE 75185 Uppsala, Sweden
Exp Mol Med 42:484-502. 2010..Our approach to associate histone methylations and DNA copy number changes to gene expression revealed apparent impact on global gene transcription, and enabled the identification of candidate tumor genes for further exploration... - Bilateral adrenalectomy for ectopic Cushing's syndrome-discussions on technique and indicationPer Hellman
Department of Surgery, University Hospital, Uppsala, SE 751 85, Sweden
World J Surg 30:909-16. 2006..Bilateral adrenalectomy may alleviate this situation, but is sometimes a troublesome procedure in these severely ill patients... - Surgical treatment of Graves' disease: evidence-based approachPeter Stalberg
Endocrine Surgical Unit, Department of Surgery, University Hospital, 751 85, Uppsala, Sweden
World J Surg 32:1269-77. 2008..than RAI or long-term antithyroid medication? (2) What is the recommended surgical approach? (3) How does the presence of Graves' ophthalmopathy (GO) influence the role of surgery? (4) What is the role of surgery in children with GD?.. - Surgical management of pancreatico-duodenal tumors in multiple endocrine neoplasia syndrome type 1Goran Akerstrom
Department of Surgery, University Hospital Uppsala, Uppsala, Sweden
Clinics (Sao Paulo) 67:173-8. 2012..This strategy, with early and aggressive surgery before metastases have developed, is believed to reduce the risks for tumor recurrence and malignant progression... - Double-detargeted oncolytic adenovirus shows replication arrest in liver cells and retains neuroendocrine cell killing abilityJustyna Leja
Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
PLoS ONE 5:e8916. 2010..Herein, we explore miRNA-based regulation of E1A expression as a complementary mechanism to promoter-based transcriptional control... - Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filterTobias Akerström
Department of Surgical Sciences, Genetics and Pathology, Uppsala University, Uppsala, Sweden
PLoS ONE 7:e41926. 2012..The prevalence and spectrum of KCNJ5 mutations in different entities of adrenocortical lesions remain to be defined... - Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigenMohammad Alimohammadi
University Hospital, Uppsala University, Uppsala, Sweden
N Engl J Med 358:1018-28. 2008.... - Allelic loss in clinically and screening-detected primary hyperparathyroidismPamela Correa
Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
Clin Endocrinol (Oxf) 56:113-7. 2002..In this study we related clinical characteristics in 56 patients with primary hyperparathyroidism (pHPT) to loss of heterozygosity (LOH) in these chromosome regions...