Goran Akerstrom

Summary

Affiliation: University Hospital
Country: Sweden

Publications

  1. ncbi request reprint Surgical treatment of endocrine pancreatic tumours
    Goran Akerstrom
    Department of Surgery, University Hospital, Uppsala, Sweden
    Neuroendocrinology 80:62-6. 2004
  2. ncbi request reprint Parathyroid glands in calcium regulation and human disease
    Goran Akerstrom
    Department of Surgical Sciences, University Hospital, Uppsala, Sweden
    Ann N Y Acad Sci 1040:53-8. 2005
  3. ncbi request reprint Primary hyperparathyroidism
    Goran Akerstrom
    Department of Surgery, University Hospital, Uppsala, Sweden
    Curr Opin Oncol 16:1-7. 2004
  4. ncbi request reprint Pancreatic tumours as part of the MEN-1 syndrome
    Goran Akerstrom
    Department of Surgical Sciences, University Hospital, SE 751 85 Uppsala, Sweden
    Best Pract Res Clin Gastroenterol 19:819-30. 2005
  5. ncbi request reprint Timing and extent of surgery in symptomatic and asymptomatic neuroendocrine tumors of the pancreas in MEN 1
    Goran Akerstrom
    Department of Surgical Sciences, University Hospital, 75185 Uppsala, Sweden
    Langenbecks Arch Surg 386:558-69. 2002
  6. doi request reprint Long-term results of surgery for small intestinal neuroendocrine tumors at a tertiary referral center
    Olov Norlén
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    World J Surg 36:1419-31. 2012
  7. ncbi request reprint Potentiating effects of nonactive/active vitamin D analogues and ketoconazole in parathyroid cells
    Ulrika Segersten
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Sweden
    Clin Endocrinol (Oxf) 66:399-404. 2007
  8. ncbi request reprint Increased 25-hydroxyvitamin D3 1alpha-hydroxylase and reduced 25-hydroxyvitamin D3 24-hydroxylase expression in parathyroid tumors--new prospects for treatment of hyperparathyroidism with vitamin d
    Pamela Correa
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    J Clin Endocrinol Metab 87:5826-9. 2002
  9. doi request reprint Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients
    Tijana Krajisnik
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Kidney Int 78:1024-32. 2010
  10. ncbi request reprint Surgery on neuroendocrine tumours
    Goran Akerstrom
    Department of Surgical Sciences, University Hospital, SE 751 85 Uppsala, Sweden
    Best Pract Res Clin Endocrinol Metab 21:87-109. 2007

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Surgical treatment of endocrine pancreatic tumours
    Goran Akerstrom
    Department of Surgery, University Hospital, Uppsala, Sweden
    Neuroendocrinology 80:62-6. 2004
    ..It has become obvious that surgical treatment of these tumours is of increased concern and can have a marked impact on symptoms and survival...
  2. ncbi request reprint Parathyroid glands in calcium regulation and human disease
    Goran Akerstrom
    Department of Surgical Sciences, University Hospital, Uppsala, Sweden
    Ann N Y Acad Sci 1040:53-8. 2005
    ..Newly developed vitamin D analogues with reduced calcemic effects and with more pronounced antiproliferative effect may provide new favorable treatment for reversal of HPT...
  3. ncbi request reprint Primary hyperparathyroidism
    Goran Akerstrom
    Department of Surgery, University Hospital, Uppsala, Sweden
    Curr Opin Oncol 16:1-7. 2004
    ..This contribution presents research progress concerning primary hyperparathyroidism (pHPT), and the background for recent notable changes in treatment policy...
  4. ncbi request reprint Pancreatic tumours as part of the MEN-1 syndrome
    Goran Akerstrom
    Department of Surgical Sciences, University Hospital, SE 751 85 Uppsala, Sweden
    Best Pract Res Clin Gastroenterol 19:819-30. 2005
    ..This strategy with early and aggressive surgery is believed to reduce the risks for malignant progression...
  5. ncbi request reprint Timing and extent of surgery in symptomatic and asymptomatic neuroendocrine tumors of the pancreas in MEN 1
    Goran Akerstrom
    Department of Surgical Sciences, University Hospital, 75185 Uppsala, Sweden
    Langenbecks Arch Surg 386:558-69. 2002
    ..More extensive surgical tumor reduction is believed to reduce the risks for malignant progression of the pancreaticoduodenal tumors, but this requires further evaluation in MEN 1...
  6. doi request reprint Long-term results of surgery for small intestinal neuroendocrine tumors at a tertiary referral center
    Olov Norlén
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    World J Surg 36:1419-31. 2012
    ..Our aim was to identify prognostic factors for survival and to evaluate outcome after surgery in SI-NET patients...
  7. ncbi request reprint Potentiating effects of nonactive/active vitamin D analogues and ketoconazole in parathyroid cells
    Ulrika Segersten
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Sweden
    Clin Endocrinol (Oxf) 66:399-404. 2007
    ..The aim of this study was to investigate biological effects of a non-1alpha-hydroxylated vitamin D analogue in normal and tumour parathyroid cells...
  8. ncbi request reprint Increased 25-hydroxyvitamin D3 1alpha-hydroxylase and reduced 25-hydroxyvitamin D3 24-hydroxylase expression in parathyroid tumors--new prospects for treatment of hyperparathyroidism with vitamin d
    Pamela Correa
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    J Clin Endocrinol Metab 87:5826-9. 2002
    ..These findings should be considered in future development of vitamin D analogues for treatment of HPT...
  9. doi request reprint Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients
    Tijana Krajisnik
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Kidney Int 78:1024-32. 2010
    ..Thus parathyroid Klotho and FGFR1 decrease with declining renal function, possibly because of alterations in mineral metabolism related to the failing kidney. This could explain the observed parathyroid resistance to FGF23 in late CKD...
  10. ncbi request reprint Surgery on neuroendocrine tumours
    Goran Akerstrom
    Department of Surgical Sciences, University Hospital, SE 751 85 Uppsala, Sweden
    Best Pract Res Clin Endocrinol Metab 21:87-109. 2007
    ..Other tumours--glucagonoma, VIPoma, and non-functioning endocrine pancreatic tumours--are often large or metastasizing, but generally require surgical debulking to alleviate hormonal symptoms and have favourable survival...
  11. ncbi request reprint Vitamin D3 polyunsaturated side-chain analogues (EB1089, GS1590) and the 20-epi-vitamin D3 analogue CB1393 suppress parathyroid hormone secretion and mRNA level in bovine parathyroid cells
    Ulrika Segersten
    Department of Surgical Sciences, Uppsala University Hospital, Klinisk forskningsavdelning 2, Ingang 70, plan 3, Lab 9, SE 751 85 Uppsala, Sweden
    J Steroid Biochem Mol Biol 88:289-94. 2004
    ..We conclude that the vitamin D analogues EB1089, GS1590 and CB1393 may be suitable for treatment of hyperparathyroidism secondary to uremia and that further evaluation in vivo should be considered...
  12. doi request reprint Surgery and radiofrequency ablation for treatment of liver metastases from midgut and foregut carcinoids and endocrine pancreatic tumors
    John Eriksson
    Department of Surgery, University Hospital, SE 751 85 Uppsala, Sweden
    World J Surg 32:930-8. 2008
    ..However, it is not clear whether such therapy will provide symptom reduction or increased survival...
  13. ncbi request reprint Management of midgut carcinoids
    Goran Akerstrom
    Department of Surgery, University Hospital, Uppsala, Sweden
    J Surg Oncol 89:161-9. 2005
    ..Favourable survival and life-quality can be expected with this treatment also in patients with advanced midgut carcinoids...
  14. pmc Stabilizing mutation of CTNNB1/beta-catenin and protein accumulation analyzed in a large series of parathyroid tumors of Swedish patients
    Peyman Björklund
    Department of Surgical Sciences, Endocrine Unit, Uppsala University, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Mol Cancer 7:53. 2008
    ..The aim of the present study was to determine the frequency and zygosity of mutations in CTNNB1 exon 3, and beta-catenin accumulation in a large series of parathyroid adenomas of Swedish patients...
  15. pmc The internally truncated LRP5 receptor presents a therapeutic target in breast cancer
    Peyman Björklund
    Department of Surgical Sciences, Endocrine Unit, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
    PLoS ONE 4:e4243. 2009
    ....
  16. doi request reprint Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene epigenetically deregulated in hyperparathyroid tumors by histone H3 lysine modification
    Jessica Svedlund
    Department of Surgical Sciences, Uppsala University, Uppsala University Hospital, Entrance 70, Third Floor, SE 75185 Uppsala, Sweden
    J Clin Endocrinol Metab 97:E1307-15. 2012
    ..In renal failure, secondary hyperparathyroidism (sHPT) occurs with multiple tumor development as a result of calcium and vitamin D regulatory disturbance...
  17. ncbi request reprint Reduced p18INK4c, p21CIP1/WAF1 and p27KIP1 mRNA levels in tumours of primary and secondary hyperparathyroidism
    Pamela Correa Buchwald
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Uppsala, Sweden
    Clin Endocrinol (Oxf) 60:389-93. 2004
    ..Cyclin-dependent kinase inhibitors (CKIs), which generally inhibit cell cycle progression, modulate the activity of cyclin-CDK complexes...
  18. doi request reprint Different gene expression profiles in metastasizing midgut carcinoid tumors
    Katarina Edfeldt
    Department of Surgical Sciences, Uppsala University, SE 751 85 Uppsala, Sweden
    Endocr Relat Cancer 18:479-89. 2011
    ..This study reveals differences in gene expression profiles and novel genes that may be of importance in midgut carcinoid tumor progression...
  19. doi request reprint Type I membrane klotho expression is decreased and inversely correlated to serum calcium in primary hyperparathyroidism
    Peyman Björklund
    Department of Medical Sciences, Uppsala University Hospital, Ing 70, 3 tr, UAS, 75185 Uppsala, Sweden
    J Clin Endocrinol Metab 93:4152-7. 2008
    ..In contrast, Klotho inhibits PTH secretion indirectly through the action of fibroblast growth factor-23. Abnormal Klotho expression in parathyroid disorders remains to be elucidated...
  20. pmc 25-Hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-1alpha-hydroxylated vitamin D analogue
    Ulrika Segersten
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Breast Cancer Res 7:R980-6. 2005
    ..In addition, expression of the 25-hydroxyvitamin D3 24-hydroxylase (24-hydroxylase) and the vitamin D receptor (VDR) was investigated...
  21. ncbi request reprint 25-hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glands
    Ulrika Segersten
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    J Clin Endocrinol Metab 87:2967-72. 2002
    ..The findings imply that in addition to feedback control by circulating 1,25(OH)(2)D(3) levels, parathyroid cells may also be influenced by local 1alpha -hydroxylase activity with possible growth regulatory and differentiating effects...
  22. ncbi request reprint Exclusive underexpression of vitamin D receptor exon 1f transcripts in tumors of primary hyperparathyroidism
    Pamela Correa
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Eur J Endocrinol 147:671-5. 2002
    ..Here we have assessed which of the 5'-terminal exon 1a, 1d and 1f variant VDR transcripts are reduced in pathological parathyroid glands...
  23. pmc Surgical management of pancreatico-duodenal tumors in multiple endocrine neoplasia syndrome type 1
    Goran Akerstrom
    Department of Surgery, University Hospital Uppsala, Uppsala, Sweden
    Clinics (Sao Paulo) 67:173-8. 2012
    ..This strategy, with early and aggressive surgery before metastases have developed, is believed to reduce the risks for tumor recurrence and malignant progression...
  24. ncbi request reprint Evaluation of CDKN2C/p18, CDKN1B/p27 and CDKN2B/p15 mRNA expression, and CpG methylation status in sporadic and MEN1-associated pancreatic endocrine tumours
    Daniel Lindberg
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Uppsala, Sweden
    Clin Endocrinol (Oxf) 68:271-7. 2008
    ..Here, we have compared the relative mRNA expression level and CpG methylation status of p18, p27 and p15 in 18 pancreatic endocrine tumours (PETs) with or without MEN1 gene mutations...
  25. ncbi request reprint Surgical management of MEN-1 and -2: state of the art
    Goran Akerstrom
    Department of Surgery, University Hospital, Uppsala, 751 85 Sweden
    Surg Clin North Am 89:1047-68. 2009
    ..Prophylactic thyroidectomy based on DNA testing in the MEN-2 syndrome is considered one of the greater achievements in cancer treatment, because it may be performed before thyroid carcinoma development and provides cure for the patient...
  26. doi request reprint Stenting of the superior mesenteric vein in midgut carcinoid disease with large mesenteric masses
    Per Hellman
    Department of Surgery, University of Uppsala, SE 751 85, Uppsala, Sweden
    World J Surg 34:1373-9. 2010
    ..These symptoms include severe abdominal pain, attacks of diarrhea, and malnutrition...
  27. pmc Aberrant WNT/β-catenin signaling in parathyroid carcinoma
    Jessica Svedlund
    Department of Surgical Sciences, Endocrine Unit, Uppsala University, SE 751 85 Uppsala, Sweden
    Mol Cancer 9:294. 2010
    ..The molecular etiology of PC is poorly understood...
  28. pmc Mutational analysis of p27 (CDKN1B) and p18 (CDKN2C) in sporadic pancreatic endocrine tumors argues against tumor-suppressor function
    Daniel Lindberg
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Uppsala, Sweden
    Neoplasia 9:533-5. 2007
    ..Three known polymorphisms were found in the p18 gene. These data suggest that p27 and p18 are unlikely to present classic tumor-suppressor genes in sporadic PETs...
  29. ncbi request reprint In situ RNA-RNA hybridisation of phospholipase C beta 3 shows lack of expression in neuroendocrine tumours
    Peter Stalberg
    Department of Surgical Sciences, University Hospital, S 751 85 Uppsala, Sweden
    Anticancer Res 23:2227-32. 2003
    ....
  30. ncbi request reprint Underexpression of Gcm2, a master regulatory gene of parathyroid gland development, in adenomas of primary hyperparathyroidism
    Pamela Correa
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Klinisk forskningsavdelning 2, SE 751 85 Uppsala, Sweden
    Clin Endocrinol (Oxf) 57:501-5. 2002
    ..Mouse Gcm2 is restricted to parathyroid tissues and Gcm2 was recently identified as a master regulatory gene of parathyroid gland development as Gcm2 knockout mice lack parathyroid glands...
  31. ncbi request reprint Cyclin-dependent kinase 4 (CDK4) expression in pancreatic endocrine tumors
    Daniel Lindberg
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Uppsala, Sweden
    Neuroendocrinology 86:112-8. 2007
    ..CDK4 is central to the cell cycle control in pancreatic beta cells, and we have assessed whether CDK4 expression is deregulated in 18 human sporadic or familial PETs...
  32. ncbi request reprint Vitamin D in normal and pathological parathyroid glands: new prospects for treating hyperparathyroidism (review)
    Pamela Correa Buchwald
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Int J Mol Med 15:701-6. 2005
    ..The growth-inhibitory properties of 1,25(OH)2D3 are prospects for treatment of hyperparathyroidism...
  33. ncbi request reprint Multiple endocrine neoplasia type 1 polymorphism D418D is associated with sporadic primary hyperparathyroidism
    Pamela Correa
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Sweden
    Surgery 132:450-5. 2002
    ..The multiple endocrine neoplasia type 1 gene is the most commonly deranged gene in parathyroid adenomas and contains several polymorphisms including D418D with a prevalence of roughly 50%...
  34. ncbi request reprint Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours
    Daniel Lindberg
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, Uppsala, Sweden
    Clin Endocrinol (Oxf) 66:110-4. 2007
    ..We have analysed whether WNT7A or HDAC11 was biallelically inactivated in a group of well-characterized PETs...
  35. doi request reprint Prophylactic cholecystectomy in midgut carcinoid patients
    Olov Norlén
    Department of Surgery, Uppsala University, SE 751 85, Uppsala, Sweden
    World J Surg 34:1361-7. 2010
    ..Prophylactic cholecystectomy has been advocated, but data to support this recommendation are sparse. We have analyzed a cohort of 235 patients with MGC focusing on the risk for gallstone formation and complications thereof...
  36. ncbi request reprint Radiofrequency tissue ablation using cooled tip for liver metastases of endocrine tumors
    Per Hellman
    Department of Surgery, University Hospital, SE 751 85 Uppsala, Sweden
    World J Surg 26:1052-6. 2002
    ..e., no residual macroscopic tumor) in 4 patients. We conclude that RF using cooled-tip needles is safe and efficient; it may be performed percutaneously and intraoperatively; and it may expand the indications for liver resection...
  37. doi request reprint The histone methyltransferase EZH2, an oncogene common to benign and malignant parathyroid tumors
    Jessica Svedlund
    Department of Surgical Sciences, Endocrine Unit, Uppsala University, Uppsala University Hospital, Entrance 70, 3 tr, SE 751 85 Uppsala, Sweden
    Endocr Relat Cancer 21:231-9. 2014
    ..This supports the possibility of a common pathway in parathyroid tumor development. ..
  38. doi request reprint High success rate of parathyroid reoperation may be achieved with improved localization diagnosis
    Ola Hessman
    Department of Surgery, University Hospital, 751 85 Uppsala, Swede
    World J Surg 32:774-81; discussion 782-3. 2008
    ..We report the use of consistently applied localization diagnosis to yield high success rates in parathyroid reoperations...
  39. ncbi request reprint Accumulation of nonphosphorylated beta-catenin and c-myc in primary and uremic secondary hyperparathyroid tumors
    Peyman Björklund
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    J Clin Endocrinol Metab 92:338-44. 2007
    ..In renal failure, secondary hyperparathyroidism (sHPT) occurs with multiple tumor development as a result of calcium and vitamin D regulatory disturbance...
  40. ncbi request reprint Molecular genetics of parathyroid disease
    Gunnar Westin
    Department of Surgical Sciences, Uppsala University Hospital, 751 85 Uppsala, Sweden
    World J Surg 33:2224-33. 2009
    ..The present contribution summarizes more recent knowledge of parathyroid molecular genetics...
  41. ncbi request reprint Recurrent genomic alterations in benign and malignant pheochromocytomas and paragangliomas revealed by whole-genome array comparative genomic hybridization analysis
    Johanna Sandgren
    Department of Surgical Sciences, Uppsala University Hospital Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
    Endocr Relat Cancer 17:561-79. 2010
    ....
  42. pmc Integrative epigenomic and genomic analysis of malignant pheochromocytoma
    Johanna Sandgren
    Department of Surgical Sciences, Uppsala University, Uppsala University Hospital, SE 75185 Uppsala, Sweden
    Exp Mol Med 42:484-502. 2010
    ..Our approach to associate histone methylations and DNA copy number changes to gene expression revealed apparent impact on global gene transcription, and enabled the identification of candidate tumor genes for further exploration...
  43. ncbi request reprint Effect of surgery on the outcome of midgut carcinoid disease with lymph node and liver metastases
    Per Hellman
    Department of Surgery, University Hospital, SE 751 85 Uppsala, Sweden
    World J Surg 26:991-7. 2002
    ..Liver metastases and significant preoperative weight loss are identified as major negative prognostic factors for survival...
  44. pmc An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling
    Peyman Björklund
    Department of Surgical Sciences, Uppsala University, Endocrine Unit, Uppsala University Hospital, Uppsala, Sweden
    PLoS Med 4:e328. 2007
    ..Mechanisms that may account for this activation have not been identified, except for a few cases of beta-catenin (CTNNB1) stabilizing mutation in pHPT tumors...
  45. ncbi request reprint Bilateral adrenalectomy for ectopic Cushing's syndrome-discussions on technique and indication
    Per Hellman
    Department of Surgery, University Hospital, Uppsala, SE 751 85, Sweden
    World J Surg 30:909-16. 2006
    ..Bilateral adrenalectomy may alleviate this situation, but is sometimes a troublesome procedure in these severely ill patients...
  46. ncbi request reprint Surgical treatment of Graves' disease: evidence-based approach
    Peter Stalberg
    Endocrine Surgical Unit, Department of Surgery, University Hospital, 751 85, Uppsala, Sweden
    World J Surg 32:1269-77. 2008
    ..than RAI or long-term antithyroid medication? (2) What is the recommended surgical approach? (3) How does the presence of Graves' ophthalmopathy (GO) influence the role of surgery? (4) What is the role of surgery in children with GD?..
  47. pmc Double-detargeted oncolytic adenovirus shows replication arrest in liver cells and retains neuroendocrine cell killing ability
    Justyna Leja
    Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    PLoS ONE 5:e8916. 2010
    ..Herein, we explore miRNA-based regulation of E1A expression as a complementary mechanism to promoter-based transcriptional control...
  48. pmc Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter
    Tobias Akerström
    Department of Surgical Sciences, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    PLoS ONE 7:e41926. 2012
    ..The prevalence and spectrum of KCNJ5 mutations in different entities of adrenocortical lesions remain to be defined...
  49. doi request reprint Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen
    Mohammad Alimohammadi
    University Hospital, Uppsala University, Uppsala, Sweden
    N Engl J Med 358:1018-28. 2008
    ....
  50. ncbi request reprint Allelic loss in clinically and screening-detected primary hyperparathyroidism
    Pamela Correa
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Clin Endocrinol (Oxf) 56:113-7. 2002
    ..In this study we related clinical characteristics in 56 patients with primary hyperparathyroidism (pHPT) to loss of heterozygosity (LOH) in these chromosome regions...