Andrej Tarkowski

Summary

Country: Sweden

Publications

  1. ncbi request reprint Staphylococcus aureus: Staphylokinase
    Maria I Bokarewa
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Guldhedsgatan 10, SE 41346 Göteborg, Sweden
    Int J Biochem Cell Biol 38:504-9. 2006
  2. ncbi request reprint Resistin, an adipokine with potent proinflammatory properties
    Maria Bokarewa
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Sweden
    J Immunol 174:5789-95. 2005
  3. ncbi request reprint Cystatin C binds serum amyloid A, downregulating its cytokine-generating properties
    Maria Bokarewa
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Goteborg, Sweden
    J Rheumatol 34:1293-301. 2007
  4. ncbi request reprint Anti-proliferative effects of phosphodiester oligodeoxynucleotides
    Jan L Bjersing
    Department of Rheumatology and Inflammation Research, University of Goteborg, Guldhetsgatan IOA, Göteborg 413 46, Sweden
    Immunobiology 209:637-45. 2004
  5. ncbi request reprint The role of urokinase in innate immunity against Staphylococcus aureus
    Tao Jin
    Department of Rheumatology and Inflammation Research, University of Goteborg, 41346 Göteborg, Sweden
    Microbes Infect 7:1170-5. 2005
  6. doi request reprint Metastasin S100A4 is increased in proportion to radiographic damage in patients with RA
    Malin C Erlandsson
    Department of Rheumatology and Inflammation Research, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    Rheumatology (Oxford) 51:932-40. 2012
  7. pmc The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis
    Anna Karin H Ekwall
    Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, Goteborg University, Box 480, 405 30 Goteborg, Sweden
    Arthritis Res Ther 13:R40. 2011
  8. pmc Decreased levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control
    Rille Pullerits
    Department of Rheumatology and Inflammation Research, University of Goteborg, Goteborg, Sweden
    Arthritis Res Ther 7:R817-24. 2005
  9. pmc Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis
    Teresia M Osborn
    Department of Rheumatology and Inflammation Research, University of Gothenburg, Guldhedsgatan 10A, S 413 46 Gothenburg, Sweden
    Arthritis Res Ther 10:R117. 2008
  10. pmc Vaccination response to protein and carbohydrate antigens in patients with rheumatoid arthritis after rituximab treatment
    Maria Rehnberg
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, and Rheumatology Clinic, Sahlgrenska University Hospital, Guldhedsgatan 10A, Gothenburg, 405 30, Sweden
    Arthritis Res Ther 12:R111. 2010

Detail Information

Publications75

  1. ncbi request reprint Staphylococcus aureus: Staphylokinase
    Maria I Bokarewa
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Guldhedsgatan 10, SE 41346 Göteborg, Sweden
    Int J Biochem Cell Biol 38:504-9. 2006
    ..Our observations indicate that staphylokinase favours symbiosis of staphylococci with the host that makes it an important colonization factor...
  2. ncbi request reprint Resistin, an adipokine with potent proinflammatory properties
    Maria Bokarewa
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Sweden
    J Immunol 174:5789-95. 2005
    ..Importantly, the identified properties of resistin make it a novel and interesting therapeutic target in chronic inflammatory diseases such as rheumatoid arthritis...
  3. ncbi request reprint Cystatin C binds serum amyloid A, downregulating its cytokine-generating properties
    Maria Bokarewa
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Goteborg, Sweden
    J Rheumatol 34:1293-301. 2007
    ..To assess the interaction between cystatin C (CysC) and serum amyloid A protein (SAA)...
  4. ncbi request reprint Anti-proliferative effects of phosphodiester oligodeoxynucleotides
    Jan L Bjersing
    Department of Rheumatology and Inflammation Research, University of Goteborg, Guldhetsgatan IOA, Göteborg 413 46, Sweden
    Immunobiology 209:637-45. 2004
    ..Thus, the O-ODNs, irrespective of CpG content, exerted inhibitory activities on the proliferation of B cells. These anti-proliferative effects appear to be mediated both by the down-regulation of IL-10 production and increased apoptosis...
  5. ncbi request reprint The role of urokinase in innate immunity against Staphylococcus aureus
    Tao Jin
    Department of Rheumatology and Inflammation Research, University of Goteborg, 41346 Göteborg, Sweden
    Microbes Infect 7:1170-5. 2005
    ..These findings indicate novel functions of HMW uPA in the host defense against staphylococcal infections...
  6. doi request reprint Metastasin S100A4 is increased in proportion to radiographic damage in patients with RA
    Malin C Erlandsson
    Department of Rheumatology and Inflammation Research, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    Rheumatology (Oxford) 51:932-40. 2012
    ..To assess the potential of metastasin S100A4 as a biological marker in patients with RA...
  7. pmc The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis
    Anna Karin H Ekwall
    Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, Goteborg University, Box 480, 405 30 Goteborg, Sweden
    Arthritis Res Ther 13:R40. 2011
    ..The aim of this study was to investigate whether podoplanin is expressed in areas of synovial transformation in RA and especially in promigratory RA-FLS...
  8. pmc Decreased levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control
    Rille Pullerits
    Department of Rheumatology and Inflammation Research, University of Goteborg, Goteborg, Sweden
    Arthritis Res Ther 7:R817-24. 2005
    ..We conclude that a decreased level of sRAGE in patients with RA might increase the propensity towards inflammation, whereas treatment with methotrexate counteracts this feature...
  9. pmc Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis
    Teresia M Osborn
    Department of Rheumatology and Inflammation Research, University of Gothenburg, Guldhedsgatan 10A, S 413 46 Gothenburg, Sweden
    Arthritis Res Ther 10:R117. 2008
    ..In the present study, we investigated plasma gelsolin in patients with rheumatoid arthritis...
  10. pmc Vaccination response to protein and carbohydrate antigens in patients with rheumatoid arthritis after rituximab treatment
    Maria Rehnberg
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, and Rheumatology Clinic, Sahlgrenska University Hospital, Guldhedsgatan 10A, Gothenburg, 405 30, Sweden
    Arthritis Res Ther 12:R111. 2010
    ..Rheumatoid arthritis (RA) is frequently complicated with infections. The aim of our study was to evaluate vaccination response in patients with RA after B-cell depletion by using rituximab...
  11. pmc Role of resistin as a marker of inflammation in systemic lupus erythematosus
    Katarina Almehed
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Göteborg University Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    Arthritis Res Ther 10:R15. 2008
    ..The aim of this study was to determine associations between serum levels of resistin and markers of inflammation and bone mineral density (BMD) in female patients with systemic lupus erythematosus (SLE)...
  12. pmc Urokinase, a constitutive component of the inflamed synovial fluid, induces arthritis
    Tao Jin
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Arthritis Res Ther 5:R9-R17. 2003
    ..Accumulation of uPA locally in the joint cavity is a typical finding in erosive RA. uPA exerts potent arthritogenic properties and thus may be viewed as one of the essential mediators of joint inflammation...
  13. pmc Balance between survivin, a key member of the apoptosis inhibitor family, and its specific antibodies determines erosivity in rheumatoid arthritis
    Maria Bokarewa
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Arthritis Res Ther 7:R349-58. 2005
    ....
  14. pmc Expression and functional properties of antibodies to tissue inhibitors of metalloproteinases (TIMPs) in rheumatoid arthritis
    Maria Bokarewa
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Arthritis Res Ther 7:R1014-22. 2005
    ..In the present study, we show that RA patients frequently develop autoimmune response to TIMPs that may act as a functionally significant regulator of MMP activity and thereby of joint destruction...
  15. ncbi request reprint Is interleukin-18 useful for monitoring rheumatoid arthritis?
    M Bokarewa
    Department of Rheumatology, Goteborg University, Sweden
    Scand J Rheumatol 34:433-6. 2005
    ..Its similarities to IL-1beta and ability to induce tumour necrosis factor-alpha (TNF-alpha) make it potentially important in the pathogenesis of rheumatoid arthritis (RA)...
  16. ncbi request reprint Human alpha -defensins neutralize fibrinolytic activity exerted by staphylokinase
    Maria Bokarewa
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    Thromb Haemost 91:991-9. 2004
    ..This finding may have clinical implications, since fibrinolytic effects of staphylokinase may be downregulated at the site of vascular occlusion...
  17. ncbi request reprint Pathological survivin expression links viral infections with pathogenesis of erosive rheumatoid arthritis
    M Bokarewa
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Goteborg University, S 41346 Goteborg, Sweden
    Scand J Immunol 66:192-8. 2007
    ..The role of IFN-alpha and the involvement of IFN transcription factors and phosphoinositide-3-kinase signalling as essential modulators of arthritogenic process are discussed in the context of survivin...
  18. ncbi request reprint Efficacy of anti-CD20 treatment in patients with rheumatoid arthritis resistant to a combination of methotrexate/anti-TNF therapy
    M Bokarewa
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Scand J Immunol 66:476-83. 2007
    ..The treatment is well tolerated and may be used repeatedly in the same patient and potentially increase sensitivity to previously inefficient treatment modalities...
  19. pmc Tissue factor as a proinflammatory agent
    Maria I Bokarewa
    Department of Rheumatology, Sahlgrenska Hospital, Goteborg, Sweden
    Arthritis Res 4:190-5. 2002
    ..TF has strong inflammatogenic properties mediated predominantly by monocytes and their release of chemokines. Our study shows that TF can simultaneously trigger the immune and coagulation systems...
  20. ncbi request reprint Phosphorotioated oligonucleotides trigger synthesis of human coagulation serine proteases
    Maria I Bokarewa
    Dept of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Thromb Haemost 88:788-93. 2002
    ..CpG containing phosphorotioated oligonucleotides (ODN) are efficient adjuvants able to enhance macrophage and B cell activities. Their impact in the generation of coagulation and fibrinolytic factors has not been analysed...
  21. pmc Local infusion of infliximab for the treatment of acute joint inflammation
    M Bokarewa
    Department of Rheumatology, Sahlgrenska University Hospital, Goteborg, Sweden
    Ann Rheum Dis 62:783-4. 2003
  22. ncbi request reprint Intra-articular tissue factor/factor VII complex induces chronic arthritis
    M I Bokarewa
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Inflamm Res 51:471-7. 2002
    ..Fibrin accumulation in the joint cavity is a common feature of chronic arthritides, such as rheumatoid arthritis (RA). Complex formation between tissue factor (TF) and factor VII (FVII) is the initial step in such a fibrin formation...
  23. pmc Leptin consumption in the inflamed joints of patients with rheumatoid arthritis
    M Bokarewa
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Ann Rheum Dis 62:952-6. 2003
    ..Leptin has been shown to participate in bone remodelling and leptin substitution reported to have a protective effect in experimental septic arthritis...
  24. ncbi request reprint Intraarticular release and accumulation of defensins and bactericidal/permeability-increasing protein in patients with rheumatoid arthritis
    Maria I Bokarewa
    Department of Rheumatology, Sahlgrenska University Hospital, Goteborg, Sweden
    J Rheumatol 30:1719-24. 2003
    ..We assessed concentrations of BPI and a-defensins in synovial fluid (SF) and matching blood samples of patients with rheumatoid arthritis (RA)...
  25. doi request reprint Single-stranded polyinosinic acid oligonucleotides trigger leukocyte production of proteins belonging to fibrinolytic and coagulation cascades
    Fariba Zare
    Department of Rheumatology and Inflammation Research, University of Goteborg, Sweden
    J Leukoc Biol 84:741-7. 2008
    ..As fibrinolytic and coagulation cascades are important components of inflammatory homeostasis, these findings might have importance for development of new, targeted therapies...
  26. pmc Ethanol prevents development of destructive arthritis
    Ing Marie Jonsson
    Department of Rheumatology and Inflammation Research and Center for Bone Research at the Sahlgrenska Academy, Goteborg University, SE 405 30 Goteborg, Sweden
    Proc Natl Acad Sci U S A 104:258-63. 2007
    ..We conclude that low but persistent ethanol consumption delays the onset and halts the progression of collagen-induced arthritis by interaction with innate immune responsiveness...
  27. pmc Intra-articular fms-like tyrosine kinase 3 ligand expression is a driving force in induction and progression of arthritis
    Mats Dehlin
    Department of Rheumatology and Inflammation Research, Goteborg University, Goteborg, Sweden
    PLoS ONE 3:e3633. 2008
    ....
  28. ncbi request reprint Soluble receptor for advanced glycation end products triggers a proinflammatory cytokine cascade via beta2 integrin Mac-1
    Rille Pullerits
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Arthritis Rheum 54:3898-907. 2006
    ..We undertook this study to assess the properties of sRAGE in vivo and in vitro and to analyze the role of sRAGE in HMGB-1-induced arthritis...
  29. ncbi request reprint Arthritogenic properties of double-stranded (viral) RNA
    Fariba Zare
    Department of Rheumatology and Inflammation Research, University of Goteborg, Gothenburg, Sweden
    J Immunol 172:5656-63. 2004
    ..These findings demonstrate that viral dsRNA is clearly arthritogenic. Importantly, macrophages and their products play an important role in the development of arthritis triggered by dsRNA...
  30. ncbi request reprint Inhibition of septic arthritis by local administration of taurine chloramine, a product of activated neutrophils
    Margareta Verdrengh
    Department of Rheumatology and Inflammation Research, Goteborg University, Sweden
    J Rheumatol 32:1513-7. 2005
    ..Since Tau-Cl has been shown to down-regulate the production of proinflammatory mediators and to exert anti-bacterial properties, we investigated the efficacy of Tau-Cl treatment for infectious arthritis...
  31. ncbi request reprint Staphylococcus aureus resists human defensins by production of staphylokinase, a novel bacterial evasion mechanism
    Tao Jin
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    J Immunol 172:1169-76. 2004
    ..Staphylokinase production may therefore be responsible in vivo for defensin resistance during S. aureus infections...
  32. ncbi request reprint Synergistic action of immunostimulatory DNA and fcgamma receptor IIB-crosslinking on B-cell phenotype and function
    Jan L Bjersing
    Department of Rheumatology and Inflammation Research, University of Goteborg, Guldhedsgatan 10A, S 413 46 Goteborg, Sweden
    Immunobiology 210:23-32. 2005
    ..In conclusion, these data show synergistic impact of CpG DNA and simultaneous FcgammaR-clustering on B cell proliferation and differentiation...
  33. pmc Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice
    Li Bian
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Guldhedsgatan 10A, Box 480, SE 405 30, Gothenburg, Sweden
    Arthritis Res Ther 11:R132. 2009
    ..The pro-apoptotic and anti-proliferative properties of DCA prompted us to investigate the effects of this compound in arthritis...
  34. ncbi request reprint Polarization of cytokine responses in B- and T-lymphocytes during Staphylococcus aureus infection
    Inger Gjertsson
    Department of Rheumatology and Inflammation Research, University of Goteborg, Guldhedsgatan 10, Göteborg S 413 46, Sweden
    Microb Pathog 35:119-24. 2003
    ..In conclusion this study shows that both B and T cells contribute to the cytokine production during S. aureus infection in a complex pattern...
  35. ncbi request reprint Uric acid, a nucleic acid degradation product, down-regulates dsRNA-triggered arthritis
    Fariba Zare
    Department of Rheumatology and Inflammation Research, University of Goteborg, Sweden
    J Leukoc Biol 79:482-8. 2006
    ..These findings demonstrate that uric acid displays a potent, distant anti-inflammatory effect in vivo. This property seems to be mediated by down-regulation of neutrophil influx to the site of inflammatory insult...
  36. ncbi request reprint Current status of pathogenetic mechanisms in staphylococcal arthritis
    Andrej Tarkowski
    Department of Rheumatology and Inflammation Research, University of Goteborg, Guldhedsgatan 10, 413 46 Goteborg, Sweden
    FEMS Microbiol Lett 217:125-32. 2002
    ..This review deals with the intricate host-bacterium interactions that occur during experimental septic arthritis, and outlines potential preventive and treatment modalities...
  37. pmc Short- and long-term effects of anti-CD20 treatment on B cell ontogeny in bone marrow of patients with rheumatoid arthritis
    Maria Rehnberg
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Guldhedsgatan 10A, Gothenburg, Sweden
    Arthritis Res Ther 11:R123. 2009
    ..In the present study we evaluated changes in the B cell phenotype in peripheral blood and bone marrow (BM) of patients with rheumatoid arthritis (RA) following anti-CD20 treatment using rituximab...
  38. ncbi request reprint Addition of bisphosphonate to antibiotic and anti-inflammatory treatment reduces bone resorption in experimental Staphylococcus aureus-induced arthritis
    Margareta Verdrengh
    Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Guldhedsgatan 10A, S 41346, Goteborg, Sweden
    J Orthop Res 25:304-10. 2007
    ..Treatment with bisphosphonates in combination with antimicrobial agents and corticosteroids significantly decreases the activity of osteoclasts in septic arthritis, thereby reducing the risk of skeletal destruction...
  39. doi request reprint Staphylococcus aureus infection triggers production of neutralizing, V8 protease-specific antibodies
    Ann Marie Calander
    Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden
    FEMS Immunol Med Microbiol 52:267-72. 2008
    ..It was concluded that exposure to Staphylococcus aureus, in addition to a massive polyclonal B-cell response, gives rise to production of exoprotease-specific antibodies displaying functional properties...
  40. ncbi request reprint Matrix metalloproteinase-9 (gelatinase B) deficiency leads to increased severity of Staphylococcus aureus-triggered septic arthritis
    Ann Marie Calander
    Department of Rheumatology and Inflammation Research, University of Gothenburg, Guldhedsgatan 10A, S 413 46 Gothenburg, Sweden
    Microbes Infect 8:1434-9. 2006
    ..Our findings indicate that deficiency in MMP-9 increases the degree of joint inflammation due to decreased bacterial clearance...
  41. ncbi request reprint Extracellular survivin up-regulates adhesion molecules on the surface of leukocytes changing their reactivity pattern
    Simona Mera
    Department of Rheumatology and Inflammation Research, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    J Leukoc Biol 83:149-55. 2008
    ..The results of our study demonstrate that extracellular survivin affects the phenotype of leukocytes having a possible impact on homing of inflammatory cells during arthritis...
  42. ncbi request reprint In vivo sortase A and clumping factor A mRNA expression during Staphylococcus aureus infection
    Elisabet Josefsson
    Department of Rheumatology and Inflammation Research, Goteborg University, Guldhedsgatan 10, Goteborg, Sweden
    Microb Pathog 44:103-10. 2008
    ..Possibly enters the majority of bacteria a metabolically dormant steady state at high bacterial loads...
  43. doi request reprint Formylated peptides are important virulence factors in Staphylococcus aureus arthritis in mice
    Inger Gjertsson
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Sweden
    J Infect Dis 205:305-11. 2012
    ..The role of formylated peptides in S. aureus infections has been unknown...
  44. ncbi request reprint The impact of Fcgamma receptors on Staphylococcus aureus infection
    Inger Gjertsson
    Department of Rheumatology and Inflammation Research, Goteborg University, Goteborg, Sweden
    Microb Pathog 33:145-52. 2002
    ..aureus infection. We conclude that expression of Fcgamma receptor II is of importance during S. aureus infection...
  45. doi request reprint The decrease of soluble RAGE levels in rheumatoid arthritis patients following hormone replacement therapy is associated with increased bone mineral density and diminished bone/cartilage turnover: a randomized controlled trial
    Rille Pullerits
    Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden
    Rheumatology (Oxford) 48:785-90. 2009
    ....
  46. ncbi request reprint Impact of site-specific nucleobase deletions on the arthritogenicity of DNA
    Jan L Bjersing
    Department of Rheumatology and Inflammation Research, University of Goteborg, Goteborg, Sweden
    Inflammation 28:159-68. 2004
    ..This study indicates that specific structural elements within the ODN sequence but outside the CpG motif, modulate the immunostimulatory properties of CpG ODNs...
  47. ncbi request reprint High mobility group box chromosomal protein 1, a DNA binding cytokine, induces arthritis
    Rille Pullerits
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, University of Goteborg, Gothenburg, Sweden
    Arthritis Rheum 48:1693-700. 2003
    ..To examine the potential role of high mobility group box chromosomal protein 1 (HMGB-1) in the pathogenesis of arthritis...
  48. ncbi request reprint Microbial superantigens as virulence factors and ways to counteract their actions
    Andrej Tarkowski
    Department of Rheumatology and Inflammation Research, Goteborg University, Sweden
    Scand J Infect Dis 35:642-6. 2003
    ..In this review, we discuss some of these strategies, as well as the potential for therapeutic applications of superantigens for the benefit of the host...
  49. ncbi request reprint Salivary resistin reflects local inflammation in Sjögren's syndrome
    Elisabeth Almer Boström
    Department of Rheumatology and Inflammation Research, Section of Oral Immunology, Clinic for Oral Medicine, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Rheumatol 35:2005-11. 2008
    ..To assess the role of resistin in primary Sjögren's syndrome (pSS) and its relation to local inflammation...
  50. doi request reprint mgrA regulates staphylococcal virulence important for induction and progression of septic arthritis and sepsis
    Ing Marie Jonsson
    Department of Rheumatology and Inflammation Research, Goteborg University, Goteborg, Sweden
    Microbes Infect 10:1229-35. 2008
    ..We conclude that mgrA regulates virulence factors important for establishment and progression of septic arthritis and sepsis...
  51. ncbi request reprint The impact of a new immunomodulator oxo-quinoline-3-carboxamide on the progression of experimental lupus
    Hans Carlsten
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Göteborg, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    Int Immunopharmacol 4:1515-23. 2004
    ..These results suggest (a) a potential therapeutic role of ABR-25757 in the treatment of experimental lupus and (b) that the effect of the treatment is mediated by immunodeviation rather than by immunosuppression...
  52. pmc Human resistin is a systemic immune-derived proinflammatory cytokine targeting both leukocytes and adipocytes
    Ivan Nagaev
    Lundberg Laboratory for Diabetes Research, Department of Internal Medicine, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    PLoS ONE 1:e31. 2006
    ..Thus, the myeloid-restricted nature of CEBPE precludes the expression of RETN in human adipocytes which, however, are targeted by this innate immune-derived proinflammatory cytokine...
  53. doi request reprint Role of CTA1R7K-COL-DD as a novel therapeutic mucosal tolerance-inducing vector for treatment of collagen-induced arthritis
    Annemarie Hasselberg
    Mucosal Immunobiology and Vaccine Research Center, Department of Microbiology and Immunology, Sahlgrenska Academy, University of Goteborg, Goteborg, Sweden
    Arthritis Rheum 60:1672-82. 2009
    ....
  54. doi request reprint Tranexamic acid, an inhibitor of plasminogen activation, aggravates staphylococcal septic arthritis and sepsis
    Marcin Kłak
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg Hospital, Goteborg, Sweden
    Scand J Infect Dis 42:351-8. 2010
    ..In conclusion, we report that treatment with tranexamic acid led to distinct aggravation of staphylococcal septic arthritis and sepsis in mice, suggesting the clinical importance of fibrinolytic balance in staphylococcal infection...
  55. doi request reprint RANKL-targeted therapy inhibits bone resorption in experimental Staphylococcus aureus-induced arthritis
    Margareta Verdrengh
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, Guldhedsgatan 10A, S 41346 Goteborg, Sweden
    Bone 46:752-8. 2010
    ..Here we assess the effect of RANKL-targeted treatments using soluble receptor decoy and osteprotegerin (OPG) on the course and outcome of staphylococcal arthritis...
  56. doi request reprint Staphylokinase reduces plasmin formation by endogenous plasminogen activators
    Tao Jin
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Eur J Haematol 81:8-17. 2008
    ..In conclusion, SAK reduces tPA/uPA-mediated Plg activation by means of SAK.Plg complex formation, consequently downregulating tPA/uPA-induced fibrinolysis...
  57. doi request reprint Arthritogenic dsRNA is present in synovial fluid from rheumatoid arthritis patients with an erosive disease course
    Maria Bokarewa
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Eur J Immunol 38:3237-44. 2008
    ....
  58. pmc Fibrinogen binding sites P336 and Y338 of clumping factor A are crucial for Staphylococcus aureus virulence
    Elisabet Josefsson
    Department of Rheumatology and Inflammation Research, University of Gothenburg, Goteborg, Sweden
    PLoS ONE 3:e2206. 2008
    ..aureus to provoke disease manifestations, and that the vaccine potential of recombinant ClfA is improved by removing its ability to bind fibrinogen...
  59. ncbi request reprint The role of B cell CD22 expression in Staphylococcus aureus arthritis and sepsis
    Inger Gjertsson
    Department of Rheumatology and Inflammation Research, Goteborg University, Guldhedsgatan 10A, SE 413 46 Goteborg, Sweden
    Microbes Infect 6:377-82. 2004
    ..This study shows explicitly that a reduced MZ B cell compartment in the absence of CD22 expression does not interfere with the inflammatory response during S. aureus infection...
  60. ncbi request reprint Longterm clinical and immunological effects of anti-CD20 treatment in patients with refractory systemic lupus erythematosus
    Catharina Lindholm
    Department of Rheumatology and Inflammation Research, Goteborg University, Gothenburg, Sweden
    J Rheumatol 35:826-33. 2008
    ....
  61. ncbi request reprint Impact of staphylococcal protease expression on the outcome of infectious arthritis
    Ann Marie Calander
    Department of Rheumatology and Inflammation Research, University of Gothenburg, Guldhedsgatan 10A, 41346 Göteborg, Sweden
    Microbes Infect 6:202-6. 2004
    ..We conclude that in the model of haematogenously spread staphylococcal arthritis, the bacterial proteases studied do not act as virulence factors...
  62. pmc Smoking and nicotine exposure delay development of collagen-induced arthritis in mice
    Sofia S Lindblad
    Department of Rheumatology and Inflammation Research, University of Gothenburg, Sahlgrenska University Hospital, Guldhedsgatan 10, Göteborg S 41346, Sweden
    Arthritis Res Ther 11:R88. 2009
    ..The aim of the present study is the evaluation of the role of cigarette smoke (CS) in the pathogenesis of collagen-induced arthritis in mice...
  63. ncbi request reprint The arthritogenic and immunostimulatory properties of phosphorothioate oligodeoxynucleotides rely on synergy between the activities of the nuclease-resistant backbone and CpG motifs
    Jan L Bjersing
    Department of Rheumatology and Inflammation Research, University of Goteborg, Sweden
    Inflammation 28:39-51. 2004
    ..This indicates that the NFkappaB signal pathway modulates CpG-mediated immunostimulation, while sequence-independent immune activation by the phosphorothioate backbone is probably signalled via a different pathway...
  64. doi request reprint Survivin is an essential mediator of arthritis interacting with urokinase signalling
    Marcin Baran
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Cell Mol Med 13:3797-808. 2009
    ..Close correlation between survivin and uPA levels in patients with RA supports the importance of this connection for the pathogenesis of arthritis...
  65. doi request reprint Resistin is stored in neutrophil granules being released upon challenge with inflammatory stimuli
    Elisabeth A Boström
    Department of Rheumatology and Inflammation Research, Goteborg University, Guldhedsgatan 10, 41346 Göteborg, Sweden
    Biochim Biophys Acta 1793:1894-900. 2009
    ..Release of resistin from the neutrophil granules probably serves the main source of resistin at the site of inflammation...
  66. ncbi request reprint Urokinase-type plasminogen activator, an endogenous antibiotic
    Tao Jin
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Goteborg, Sweden
    J Infect Dis 192:429-37. 2005
    ..The decreased active uPA levels in infected organs might be due to the dramatically increased PAI-1 production during S. aureus infection...
  67. pmc Induction of arthritis by high mobility group box chromosomal protein 1 is independent of tumour necrosis factor signalling
    Rille Pullerits
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Goteborg University, Guldhedsgatan 10A, 41346, Goteborg, Sweden
    Arthritis Res Ther 10:R72. 2008
    ....
  68. doi request reprint Resistin competes with lipopolysaccharide for binding to toll-like receptor 4
    Andrej Tarkowski
    Department of Rheumatology and Inflammation Research, University of Goteborg, Goteborg, Sweden
    J Cell Mol Med 14:1419-31. 2010
    ..Results demonstrate that TLR4 serves as a receptor for the pro-inflammatory effects of resistin in human cells. This may partly explain the multifunctional role of resistin in chronic inflammation, atherosclerosis and insulin resistance...
  69. ncbi request reprint Thrombin generation and mortality during Staphylococcus aureus sepsis
    M I Bokarewa
    Department of Rheumatology, Sahlgrenska University Hospital, Goteborg, Sweden
    Microb Pathog 30:247-52. 2001
    ..Supplementation with neither protein C or APC favoured survival in S. aureus sepsis. Reduction in thrombin generation in response to protein C supplementation was associated with significantly increased survival...
  70. doi request reprint Resistin is associated with breach of tolerance and anti-nuclear antibodies in patients with hepatobiliary inflammation
    E A Boström
    Department of Rheumatology and Inflammation Research, University of Gothenburg, Sweden
    Scand J Immunol 74:463-70. 2011
    ..e. ANA positivity. Thus, we propose that resistin may be an important marker of disease severity in autoantibody-mediated gastrointestinal inflammatory diseases...
  71. ncbi request reprint Fatal outcome of bacteraemic patients caused by infection with staphylokinase-deficient Staphylococcus aureus strains
    Tao Jin
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    J Med Microbiol 52:919-23. 2003
    ..aureus bacteraemia. The high frequency of SAK production in nasal isolates and in cases with uncomplicated bacteraemia suggests that SAK may be one of the adaptive mechanisms of S. aureus symbiosis with the host...
  72. doi request reprint Activation of plasminogen by staphylokinase reduces the severity of Staphylococcus aureus systemic infection
    Jakub Kwieciński
    Departments of Rheumatology and Inflammation Research, Sahlgrenska Academy, Gothenburg University, Box 480, 40530 Goteborg, Sweden
    J Infect Dis 202:1041-9. 2010
    ..It is an extracellular protein that activates the conversion of human plasminogen (plg) to plasmin. The role played by SAK in staphylococcal infection is unclear...
  73. pmc Phenotypic and functional characterization of human CD25+ B cells
    Mikael Brisslert
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Immunology 117:548-57. 2006
    ..Finally, the differential regulation of CD25 expression via selective TLR ligands suggests a role for CD25+ B cells in bridging innate and acquired immune responses...
  74. pmc The surface protein Pls of methicillin-resistant Staphylococcus aureus is a virulence factor in septic arthritis
    Elisabet Josefsson
    Department of Rheumatology, University of Goteborg, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    Infect Immun 73:2812-7. 2005
    ..However, there was no evident inflammatory effect due to the Pls molecule alone, as indicated by knee injection of purified Pls. In conclusion, the results show that Pls is a virulence factor for septic arthritis and sepsis...
  75. pmc Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis of autoimmune arthritis
    Piotr Mydel
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, University of Goteborg, Goteborg, Sweden
    J Immunol 184:6882-90. 2010
    ....