D I Andersson

Summary

Affiliation: Swedish Institute for Infectious Disease Control
Country: Sweden

Publications

  1. ncbi request reprint The biological cost of antibiotic resistance
    D I Andersson
    Department of Bacteriology Swedish Institute for Infectious Disease Control S 17182, Solna, Sweden
    Curr Opin Microbiol 2:489-93. 1999
  2. ncbi request reprint Persistence of antibiotic resistant bacteria
    Dan I Andersson
    Swedish Institute for Infectious Disease Control, Dept of Bacteriology, Nobels Väg 18, S 171 82, Stockholm, Sweden
    Curr Opin Microbiol 6:452-6. 2003
  3. doi request reprint A multi-type branching model with varying environment for bacterial dynamics with postantibiotic effect
    Patricia Geli
    Department of Mathematics, Stockholm University, Stockholm, Sweden
    J Theor Biol 256:58-64. 2009
  4. ncbi request reprint Compensatory adaptation to the deleterious effect of antibiotic resistance in Salmonella typhimurium
    Sophie Maisnier-Patin
    Department of Bacteriology, Swedish Insitute for Infectious Disease Control, Solna, Sweden
    Mol Microbiol 46:355-66. 2002
  5. pmc Biological costs and mechanisms of fosfomycin resistance in Escherichia coli
    Annika I Nilsson
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, S 171 82 Stockholm, Sweden
    Antimicrob Agents Chemother 47:2850-8. 2003
  6. pmc Virulence of antibiotic-resistant Salmonella typhimurium
    J Bjorkman
    Swedish Institute for Infectious Disease Control, S 10521, Stockholm, Sweden
    Proc Natl Acad Sci U S A 95:3949-53. 1998
  7. ncbi request reprint Reduction of the fitness burden of quinolone resistance in Pseudomonas aeruginosa
    Elisabeth Kugelberg
    Swedish Institute for Infectious Disease Control, Department of Bacteriology, S 171 82 Solna, Sweden
    J Antimicrob Chemother 55:22-30. 2005
  8. pmc Slow genetic divergence of Helicobacter pylori strains during long-term colonization
    Annelie Lundin
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, SE 171 82 Solna, Sweden
    Infect Immun 73:4818-22. 2005
  9. pmc Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes
    Annika I Nilsson
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, S 171 82 Solna, Sweden
    Proc Natl Acad Sci U S A 103:6976-81. 2006
  10. ncbi request reprint Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolution
    Sophie Maisnier-Patin
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, 171 82 Solna, Sweden
    Res Microbiol 155:360-9. 2004

Collaborators

Detail Information

Publications25

  1. ncbi request reprint The biological cost of antibiotic resistance
    D I Andersson
    Department of Bacteriology Swedish Institute for Infectious Disease Control S 17182, Solna, Sweden
    Curr Opin Microbiol 2:489-93. 1999
    ..The data available from recent laboratory studies suggest that most, but not all, resistance-determining mutations and accessory elements engender some fitness cost, but those costs are likely to be ameliorated by subsequent evolution...
  2. ncbi request reprint Persistence of antibiotic resistant bacteria
    Dan I Andersson
    Swedish Institute for Infectious Disease Control, Dept of Bacteriology, Nobels Väg 18, S 171 82, Stockholm, Sweden
    Curr Opin Microbiol 6:452-6. 2003
    ..Thus, it is of importance that we forcefully implement strategies to reduce the rate of appearance and spread of resistant bacteria to allow new drug discovery to catch up with bacterial resistance development...
  3. doi request reprint A multi-type branching model with varying environment for bacterial dynamics with postantibiotic effect
    Patricia Geli
    Department of Mathematics, Stockholm University, Stockholm, Sweden
    J Theor Biol 256:58-64. 2009
    ..Data from an in vitro study with Escherichia coli exposed to different dosing regimens of cefotaxime were used to evaluate the model...
  4. ncbi request reprint Compensatory adaptation to the deleterious effect of antibiotic resistance in Salmonella typhimurium
    Sophie Maisnier-Patin
    Department of Bacteriology, Swedish Insitute for Infectious Disease Control, Solna, Sweden
    Mol Microbiol 46:355-66. 2002
    ..Our results show that the deleterious effects of a resistance mutation can be compensated by an unexpected variety of mutations...
  5. pmc Biological costs and mechanisms of fosfomycin resistance in Escherichia coli
    Annika I Nilsson
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, S 171 82 Stockholm, Sweden
    Antimicrob Agents Chemother 47:2850-8. 2003
    ..According to the mathematical model, the reduced growth rate of the resistant strains will prevent them from establishing in the bladder, which could explain why fosfomycin resistance remains rare in clinical isolates...
  6. pmc Virulence of antibiotic-resistant Salmonella typhimurium
    J Bjorkman
    Swedish Institute for Infectious Disease Control, S 10521, Stockholm, Sweden
    Proc Natl Acad Sci U S A 95:3949-53. 1998
    ..Thus, second-site compensatory mutations could increase the fitness of resistant bacteria and allow them to persist and compete successfully with sensitive strains even in an antibiotic-free environment...
  7. ncbi request reprint Reduction of the fitness burden of quinolone resistance in Pseudomonas aeruginosa
    Elisabeth Kugelberg
    Swedish Institute for Infectious Disease Control, Department of Bacteriology, S 171 82 Solna, Sweden
    J Antimicrob Chemother 55:22-30. 2005
    ..We have analysed the effect of quinolone resistance caused by DNA gyrase/topoisomerase IV mutations on bacterial fitness...
  8. pmc Slow genetic divergence of Helicobacter pylori strains during long-term colonization
    Annelie Lundin
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, SE 171 82 Solna, Sweden
    Infect Immun 73:4818-22. 2005
    ..These results suggest that previous estimates of the rate of genetic change in H. pylori within an individual might be overestimates...
  9. pmc Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes
    Annika I Nilsson
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, S 171 82 Solna, Sweden
    Proc Natl Acad Sci U S A 103:6976-81. 2006
    ..Amplified units varied in size from 1.9 to 94 kbp. Suppression of deleterious mutations by gene amplification may be involved in the evolution of new gene functions...
  10. ncbi request reprint Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolution
    Sophie Maisnier-Patin
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, 171 82 Solna, Sweden
    Res Microbiol 155:360-9. 2004
    ....
  11. pmc Effect of rpoB mutations conferring rifampin resistance on fitness of Mycobacterium tuberculosis
    Deneke H Mariam
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, S 171 82 Solna, Sweden
    Antimicrob Agents Chemother 48:1289-94. 2004
    ..0) depending on the specific mutant and assay system. Unexpectedly, the relative fitness ranking of the mutants differed between the different assays. In conclusion, rifampin resistance is associated with a cost that is conditional...
  12. doi request reprint Restored fitness leads to long-term persistence of resistant Bacteroides strains in the human intestine
    Sonja Lofmark
    Department of Laboratory Medicine, Division of Clinical Microbiology, F82, Karolinska University Hospital, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Anaerobe 14:157-60. 2008
    ..The results indicate that the biological cost associated with a resistance gene can rapidly be compensated during in vivo growth. Thus, once the resistant clone has gained its resistance determinant it will be difficult to eliminate...
  13. ncbi request reprint Multiple mechanisms to ameliorate the fitness burden of mupirocin resistance in Salmonella typhimurium
    Wilhelm Paulander
    Department of Bacteriology, Swedish Institute for Infectious Disease Control and Microbiology, Tumor and Cell Biology Center, Karolinska Institute, S 171 82 Solna, Sweden
    Mol Microbiol 64:1038-48. 2007
    ..Our findings show that the fitness costs of ileS mutations conferring mupirocin resistance can be reduced by several types of mechanisms that may contribute to the stability of mupirocin resistance in clinical settings...
  14. doi request reprint Nitrofurantoin resistance mechanism and fitness cost in Escherichia coli
    Linus Sandegren
    Department of Medical Biochemistry and Microbiology, Uppsala University, S 75123 Uppsala, Sweden
    J Antimicrob Chemother 62:495-503. 2008
    ..We identified mutations conferring nitrofurantoin resistance and examined their effect on the fitness of clinical Escherichia coli isolates...
  15. ncbi request reprint Compensatory evolution reveals functional interactions between ribosomal proteins S12, L14 and L19
    Sophie Maisnier-Patin
    Department of Bacteriology, Swedish Institute for Infectious Disease Control and Microbiology and Tumor Center, Karolinska Institute, S 17182 Solna, Sweden
    J Mol Biol 366:207-15. 2007
    ..Moreover, our study demonstrates how compensatory fitness-evolution can be used to discover new molecular functions of ribosomal proteins...
  16. ncbi request reprint Antibiotic treatment in vitro of phenotypically tolerant bacterial populations
    Camilla Wiuff
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, S 751 23 Uppsala, Sweden
    J Antimicrob Chemother 59:254-63. 2007
    ..We compared the microbiological efficacy of six antibiotics against tolerant cells and by mathematical modelling explored the potential clinical implications of tolerance...
  17. ncbi request reprint Predicting antibiotic resistance
    Jose L Martinez
    Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública and Unidad Asociada al CSIC Resistencia a los Antibióticos y Virulencia Bacteriana, Cantoblanco, 28049 Madrid, Spain
    Nat Rev Microbiol 5:958-65. 2007
    ..To this end, we propose the establishment of methodological guidelines that will allow researchers to predict the emergence of resistance to a new antibiotic before its clinical introduction...
  18. ncbi request reprint The biological cost of mutational antibiotic resistance: any practical conclusions?
    Dan I Andersson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, S 751 23 Uppsala, Sweden
    Curr Opin Microbiol 9:461-5. 2006
    ..Conceivably we can use this knowledge to rationally choose and design targets and drugs where the costs of resistance are the highest, and where the likelihood of compensation is the lowest...
  19. pmc Pharmacodynamic model to describe the concentration-dependent selection of cefotaxime-resistant Escherichia coli
    Sara K Olofsson
    Antibiotic Research Unit, Department of Medical Sciences, Clinical Bacteriology and Infectious Diseases, Uppsala University, Sweden
    Antimicrob Agents Chemother 49:5081-91. 2005
    ....
  20. pmc Persistence of resistant Staphylococcus epidermidis after single course of clarithromycin
    Maria Sjolund
    University Hospital, Uppsala, Sweden
    Emerg Infect Dis 11:1389-93. 2005
    ..We show that macrolide-resistant strains of S. epidermidis were selected during therapy and that the same resistant strain may persist for 4 years, in the absence of further antimicrobial treatment...
  21. ncbi request reprint Fitness of antibiotic resistant Staphylococcus epidermidis assessed by competition on the skin of human volunteers
    Ingegerd Gustafsson
    Department of Medical Sciences, Clinical Bacteriology, Box 552, Uppsala University, S 751 22 Uppsala, Sweden
    J Antimicrob Chemother 52:258-63. 2003
    ..However, there are limited experimental data on the relative fitness of resistant and susceptible bacteria during growth in their natural environment...
  22. pmc Polymorphic mutation frequencies in Escherichia coli: emergence of weak mutators in clinical isolates
    Maria Rosario Baquero
    Servicio de Microbiologia, Hospital Ramon y Cajal, Madrid, Spain
    J Bacteriol 186:5538-42. 2004
    ..7% were strongly hypermutable (f > or = 4 x 10(-7)). Weak mutators were apparently more frequent in southern Europe and in blood isolates (38%) than in urinary tract isolates (25%) and feces of healthy volunteers (11%)...
  23. pmc Fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium with low fitness in vivo are defective in RpoS induction
    Mirjana Macvanin
    Department of Cell and Molecular Biology, The Biomedical Center, Uppsala University, S 751 24 Uppsala, Sweden
    Antimicrob Agents Chemother 47:3743-9. 2003
    ..The low fitness of Fusr mutants in vivo suggests that drugs that can alter the levels of global regulators of gene expression deserve attention as potential antimicrobial agents...
  24. ncbi request reprint Bacteria with increased mutation frequency and antibiotic resistance are enriched in the commensal flora of patients with high antibiotic usage
    Ingegerd Gustafsson
    Antibiotic Research Unit, Department of Medical Sciences, Section of Clinical Bacteriology, Uppsala University Hospital, Uppsala, Sweden
    J Antimicrob Chemother 52:645-50. 2003
    ..pharynx (alpha-streptococci) and nostril (coagulase-negative staphylococci, CoNS)...
  25. ncbi request reprint Long-term persistence of resistant Enterococcus species after antibiotics to eradicate Helicobacter pylori
    Maria Sjolund
    University Hospital Uppsala, Uppsala, Sweden
    Ann Intern Med 139:483-7. 2003
    ..Antibiotic treatment selects for resistance not only in the pathogen to which it is directed but also in the indigenous microflora...