D I AnderssonSummaryAffiliation: Swedish Institute for Infectious Disease Control Country: Sweden Publications
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Publications
The biological cost of antibiotic resistanceD I Andersson
Department of Bacteriology Swedish Institute for Infectious Disease Control S 17182, Solna, Sweden
Curr Opin Microbiol 2:489-93. 1999..The data available from recent laboratory studies suggest that most, but not all, resistance-determining mutations and accessory elements engender some fitness cost, but those costs are likely to be ameliorated by subsequent evolution...- Persistence of antibiotic resistant bacteriaDan I Andersson
Swedish Institute for Infectious Disease Control, Dept of Bacteriology, Nobels Väg 18, S 171 82, Stockholm, Sweden
Curr Opin Microbiol 6:452-6. 2003..Thus, it is of importance that we forcefully implement strategies to reduce the rate of appearance and spread of resistant bacteria to allow new drug discovery to catch up with bacterial resistance development... 
A multi-type branching model with varying environment for bacterial dynamics with postantibiotic effectPatricia Geli
Department of Mathematics, Stockholm University, Stockholm, Sweden
J Theor Biol 256:58-64. 2009..Data from an in vitro study with Escherichia coli exposed to different dosing regimens of cefotaxime were used to evaluate the model...- Compensatory adaptation to the deleterious effect of antibiotic resistance in Salmonella typhimuriumSophie Maisnier-Patin
Department of Bacteriology, Swedish Insitute for Infectious Disease Control, Solna, Sweden
Mol Microbiol 46:355-66. 2002..Our results show that the deleterious effects of a resistance mutation can be compensated by an unexpected variety of mutations... 
Biological costs and mechanisms of fosfomycin resistance in Escherichia coliAnnika I Nilsson
Department of Bacteriology, Swedish Institute for Infectious Disease Control, S 171 82 Stockholm, Sweden
Antimicrob Agents Chemother 47:2850-8. 2003..According to the mathematical model, the reduced growth rate of the resistant strains will prevent them from establishing in the bladder, which could explain why fosfomycin resistance remains rare in clinical isolates...- Virulence of antibiotic-resistant Salmonella typhimuriumJ Bjorkman
Swedish Institute for Infectious Disease Control, S 10521, Stockholm, Sweden
Proc Natl Acad Sci U S A 95:3949-53. 1998..Thus, second-site compensatory mutations could increase the fitness of resistant bacteria and allow them to persist and compete successfully with sensitive strains even in an antibiotic-free environment... - Reduction of the fitness burden of quinolone resistance in Pseudomonas aeruginosaElisabeth Kugelberg
Swedish Institute for Infectious Disease Control, Department of Bacteriology, S-171 82 Solna, Sweden
J Antimicrob Chemother 55:22-30. 2005..CONCLUSIONS: Our results show that 'no cost' and compensatory mutations are common in quinolone-resistant P. aeruginosa... - Slow genetic divergence of Helicobacter pylori strains during long-term colonizationAnnelie Lundin
Department of Bacteriology, Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden
Infect Immun 73:4818-22. 2005..These results suggest that previous estimates of the rate of genetic change in H. pylori within an individual might be overestimates... - Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genesAnnika I Nilsson
Department of Bacteriology, Swedish Institute for Infectious Disease Control, S-171 82 Solna, Sweden
Proc Natl Acad Sci U S A 103:6976-81. 2006..Amplified units varied in size from 1.9 to 94 kbp. Suppression of deleterious mutations by gene amplification may be involved in the evolution of new gene functions... - Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolutionSophie Maisnier-Patin
Department of Bacteriology, Swedish Institute for Infectious Disease Control, 171 82 Solna, Sweden
Res Microbiol 155:360-9. 2004.... - Effect of rpoB mutations conferring rifampin resistance on fitness of Mycobacterium tuberculosisDeneke H Mariam
Department of Bacteriology, Swedish Institute for Infectious Disease Control, S-171 82 Solna, Sweden
Antimicrob Agents Chemother 48:1289-94. 2004..0) depending on the specific mutant and assay system. Unexpectedly, the relative fitness ranking of the mutants differed between the different assays. In conclusion, rifampin resistance is associated with a cost that is conditional... - Restored fitness leads to long-term persistence of resistant Bacteroides strains in the human intestineSonja Lofmark
Department of Laboratory Medicine, Division of Clinical Microbiology, F82, Karolinska University Hospital, Karolinska Institutet, SE 141 86 Stockholm, Sweden
Anaerobe 14:157-60. 2008..The results indicate that the biological cost associated with a resistance gene can rapidly be compensated during in vivo growth. Thus, once the resistant clone has gained its resistance determinant it will be difficult to eliminate... - Multiple mechanisms to ameliorate the fitness burden of mupirocin resistance in Salmonella typhimuriumWilhelm Paulander
Department of Bacteriology, Swedish Institute for Infectious Disease Control and Microbiology, Tumor and Cell Biology Center, Karolinska Institute, S 171 82 Solna, Sweden
Mol Microbiol 64:1038-48. 2007..Our findings show that the fitness costs of ileS mutations conferring mupirocin resistance can be reduced by several types of mechanisms that may contribute to the stability of mupirocin resistance in clinical settings... - Nitrofurantoin resistance mechanism and fitness cost in Escherichia coliLinus Sandegren
Department of Medical Biochemistry and Microbiology, Uppsala University, S 75123 Uppsala, Sweden
J Antimicrob Chemother 62:495-503. 2008..We identified mutations conferring nitrofurantoin resistance and examined their effect on the fitness of clinical Escherichia coli isolates... - Compensatory evolution reveals functional interactions between ribosomal proteins S12, L14 and L19Sophie Maisnier-Patin
Department of Bacteriology, Swedish Institute for Infectious Disease Control and Microbiology and Tumor Center, Karolinska Institute, S 17182 Solna, Sweden
J Mol Biol 366:207-15. 2007..Moreover, our study demonstrates how compensatory fitness-evolution can be used to discover new molecular functions of ribosomal proteins... - Antibiotic treatment in vitro of phenotypically tolerant bacterial populationsCamilla Wiuff
Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, S 751 23 Uppsala, Sweden
J Antimicrob Chemother 59:254-63. 2007..We compared the microbiological efficacy of six antibiotics against tolerant cells and by mathematical modelling explored the potential clinical implications of tolerance... - Predicting antibiotic resistanceJose L Martinez
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública and Unidad Asociada al CSIC Resistencia a los Antibióticos y Virulencia Bacteriana, Cantoblanco, 28049 Madrid, Spain
Nat Rev Microbiol 5:958-65. 2007..To this end, we propose the establishment of methodological guidelines that will allow researchers to predict the emergence of resistance to a new antibiotic before its clinical introduction... - The biological cost of mutational antibiotic resistance: any practical conclusions?Dan I Andersson
Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, S 751 23 Uppsala, Sweden
Curr Opin Microbiol 9:461-5. 2006..Conceivably we can use this knowledge to rationally choose and design targets and drugs where the costs of resistance are the highest, and where the likelihood of compensation is the lowest... - Pharmacodynamic model to describe the concentration-dependent selection of cefotaxime-resistant Escherichia coliSara K Olofsson
Antibiotic Research Unit, Department of Medical Sciences, Clinical Bacteriology and Infectious Diseases, Uppsala University, Sweden
Antimicrob Agents Chemother 49:5081-91. 2005.... - Persistence of resistant Staphylococcus epidermidis after single course of clarithromycinMaria Sjolund
University Hospital, Uppsala, Sweden
Emerg Infect Dis 11:1389-93. 2005..We show that macrolide-resistant strains of S. epidermidis were selected during therapy and that the same resistant strain may persist for 4 years, in the absence of further antimicrobial treatment... - Fitness of antibiotic resistant Staphylococcus epidermidis assessed by competition on the skin of human volunteersIngegerd Gustafsson
Department of Medical Sciences, Clinical Bacteriology, Box 552, Uppsala University, S 751 22 Uppsala, Sweden
J Antimicrob Chemother 52:258-63. 2003..However, there are limited experimental data on the relative fitness of resistant and susceptible bacteria during growth in their natural environment... - Polymorphic mutation frequencies in Escherichia coli: emergence of weak mutators in clinical isolatesMaria Rosario Baquero
Servicio de Microbiologia, Hospital Ramon y Cajal, Madrid, Spain
J Bacteriol 186:5538-42. 2004..7% were strongly hypermutable (f > or = 4 x 10(-7)). Weak mutators were apparently more frequent in southern Europe and in blood isolates (38%) than in urinary tract isolates (25%) and feces of healthy volunteers (11%)... - Fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium with low fitness in vivo are defective in RpoS inductionMirjana Macvanin
Department of Cell and Molecular Biology, The Biomedical Center, Uppsala University, S-751 24 Uppsala, Sweden
Antimicrob Agents Chemother 47:3743-9. 2003..The low fitness of Fusr mutants in vivo suggests that drugs that can alter the levels of global regulators of gene expression deserve attention as potential antimicrobial agents... - Bacteria with increased mutation frequency and antibiotic resistance are enriched in the commensal flora of patients with high antibiotic usageIngegerd Gustafsson
Antibiotic Research Unit, Department of Medical Sciences, Section of Clinical Bacteriology, Uppsala University Hospital, Uppsala, Sweden
J Antimicrob Chemother 52:645-50. 2003..024) but not for rifampicin resistance (P=0.74). CONCLUSIONS: High antibiotic use selected for commensals with highly increased resistance and a slight increase in mutation frequency... - Long-term persistence of resistant Enterococcus species after antibiotics to eradicate Helicobacter pyloriMaria Sjolund
University Hospital Uppsala, Uppsala, Sweden
Ann Intern Med 139:483-7. 2003..Antibiotic treatment selects for resistance not only in the pathogen to which it is directed but also in the indigenous microflora...