Ann Mari Svennerholm

Summary

Country: Sweden

Publications

  1. doi request reprint Recent progress toward an enterotoxigenic Escherichia coli vaccine
    Ann Mari Svennerholm
    Gothenburg University Vaccine Research Institute and Department of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Sweden
    Expert Rev Vaccines 11:495-507. 2012
  2. ncbi request reprint Priming and expression of immune responses in the gastric mucosa
    Ann Mari Svennerholm
    Department of Medical Microbiology and Immunology, Göteborg University Vaccine Research Institute GUVAX, Goteborg University, P O Box 435, 405 30 Goteborg, Sweden
    Microbes Infect 5:731-9. 2003
  3. pmc From cholera to enterotoxigenic Escherichia coli (ETEC) vaccine development
    Ann Mari Svennerholm
    WHO Collaborating Centre for Research on ETEC and Gothenburg University Vaccine Research Institute GUVAX, Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
    Indian J Med Res 133:188-96. 2011
  4. ncbi request reprint Prospects for a mucosally-administered vaccine against Helicobacter pylori
    Ann Mari Svennerholm
    Department of Medical Microbiology and Immunology, Göteborg University Research Institute GUVAX, Goteborg University, PO Box 435, 40530, Goteborg, Sweden
    Vaccine 21:347-53. 2003
  5. ncbi request reprint Microbial-gut interactions in health and disease. Progress in enteric vaccine development
    Ann Mari Svennerholm
    Department of Medical Microbiology and Immunology, and Göteborg University Vaccine Institute GUVAX, Goteborg University, P O Box 435, Goteborg S 405 30, Sweden
    Best Pract Res Clin Gastroenterol 18:421-45. 2004
  6. ncbi request reprint Progress in vaccine development against Helicobacter pylori
    Ann Mari Svennerholm
    Department of Microbiology and Immunology, Institute of Biomedicine, Goteborg University, Goteborg, Sweden
    FEMS Immunol Med Microbiol 50:146-56. 2007
  7. doi request reprint Vaccines against enterotoxigenic Escherichia coli
    Ann Mari Svennerholm
    Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, S 40530, Gothenburg, Sweden
    Expert Rev Vaccines 7:795-804. 2008
  8. ncbi request reprint In vivo expression of the heat stable (estA) and heat labile (eltB) toxin genes of enterotoxigenic Escherichia coli (ETEC)
    Asa Sjoling
    Institute of Biomedicine, Department of Microbiology and Immunology, Goteborg University, Box 435, 405 30 Goteborg, Sweden
    Microbes Infect 8:2797-802. 2006
  9. ncbi request reprint The local and systemic T-cell response to Helicobacter pylori in gastric cancer patients is characterised by production of interleukin-10
    B Samuel Lundin
    Department of Microbiology and Immunology, Institute of Biomedicine, Göteborg University Vaccine Research Institute, Goteborg University, Goteborg, Sweden
    Clin Immunol 125:205-13. 2007
  10. ncbi request reprint Comparison of different routes of vaccination for eliciting antibody responses in the human stomach
    Eva Liz Johansson
    Department of Medical Microbiology and Immunology, Göteborg University Vaccine Institute, Goteborg University, Box 435, SE 405 30 Goteborg, Sweden
    Vaccine 22:984-90. 2004

Detail Information

Publications71

  1. doi request reprint Recent progress toward an enterotoxigenic Escherichia coli vaccine
    Ann Mari Svennerholm
    Gothenburg University Vaccine Research Institute and Department of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Sweden
    Expert Rev Vaccines 11:495-507. 2012
    ..They also discuss possibilities of enhancing immune responses to candidate ETEC vaccines, particularly in children...
  2. ncbi request reprint Priming and expression of immune responses in the gastric mucosa
    Ann Mari Svennerholm
    Department of Medical Microbiology and Immunology, Göteborg University Vaccine Research Institute GUVAX, Goteborg University, P O Box 435, 405 30 Goteborg, Sweden
    Microbes Infect 5:731-9. 2003
    ..pylori infection, as well as lymphocyte homing within the common mucosal immune system, and the importance of immunisation route are discussed...
  3. pmc From cholera to enterotoxigenic Escherichia coli (ETEC) vaccine development
    Ann Mari Svennerholm
    WHO Collaborating Centre for Research on ETEC and Gothenburg University Vaccine Research Institute GUVAX, Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
    Indian J Med Res 133:188-96. 2011
    ..coli strains overexpressing the major CFs and a more LT like hybrid toxoid (LCTBA) has been developed. This vaccine will be tested soon alone and together with a mucosal adjuvant, i.e. dmLT, in clinical trials...
  4. ncbi request reprint Prospects for a mucosally-administered vaccine against Helicobacter pylori
    Ann Mari Svennerholm
    Department of Medical Microbiology and Immunology, Göteborg University Research Institute GUVAX, Goteborg University, PO Box 435, 40530, Goteborg, Sweden
    Vaccine 21:347-53. 2003
  5. ncbi request reprint Microbial-gut interactions in health and disease. Progress in enteric vaccine development
    Ann Mari Svennerholm
    Department of Medical Microbiology and Immunology, and Göteborg University Vaccine Institute GUVAX, Goteborg University, P O Box 435, Goteborg S 405 30, Sweden
    Best Pract Res Clin Gastroenterol 18:421-45. 2004
    ..In this chapter we describe the properties and availability of the recently licensed vaccines and present an update on the diverse efforts being made to achieve new or improved vaccines against the most prevalent enteropathogens...
  6. ncbi request reprint Progress in vaccine development against Helicobacter pylori
    Ann Mari Svennerholm
    Department of Microbiology and Immunology, Institute of Biomedicine, Goteborg University, Goteborg, Sweden
    FEMS Immunol Med Microbiol 50:146-56. 2007
    ..pylori as well as to identify a cocktail of strong protective antigens, or recombinant bacterial strains that express such antigens, that could be administered by a regimen that gives rise to effective immune responses in humans...
  7. doi request reprint Vaccines against enterotoxigenic Escherichia coli
    Ann Mari Svennerholm
    Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, S 40530, Gothenburg, Sweden
    Expert Rev Vaccines 7:795-804. 2008
    ..Against this background, intense efforts are in progress to try to improve the immunogenicity of different available candidate vaccines, as well as to develop new types of ETEC vaccines...
  8. ncbi request reprint In vivo expression of the heat stable (estA) and heat labile (eltB) toxin genes of enterotoxigenic Escherichia coli (ETEC)
    Asa Sjoling
    Institute of Biomedicine, Department of Microbiology and Immunology, Goteborg University, Box 435, 405 30 Goteborg, Sweden
    Microbes Infect 8:2797-802. 2006
    ..We found that estA and eltB are expressed in the in vivo samples but no significant up-or down regulation of the expression levels of either estA or eltB could be determined in vivo as compared to in vitro...
  9. ncbi request reprint The local and systemic T-cell response to Helicobacter pylori in gastric cancer patients is characterised by production of interleukin-10
    B Samuel Lundin
    Department of Microbiology and Immunology, Institute of Biomedicine, Göteborg University Vaccine Research Institute, Goteborg University, Goteborg, Sweden
    Clin Immunol 125:205-13. 2007
    ..pylori-infected GC patients leads to a diminished cytotoxic anti-tumour T-cell response in the stomach, which may contribute to tumour progression in subjects suffering from GC...
  10. ncbi request reprint Comparison of different routes of vaccination for eliciting antibody responses in the human stomach
    Eva Liz Johansson
    Department of Medical Microbiology and Immunology, Göteborg University Vaccine Institute, Goteborg University, Box 435, SE 405 30 Goteborg, Sweden
    Vaccine 22:984-90. 2004
    ..We conclude that oral vaccination is the optimal route for induction of antigen-specific IgA antibody responses in the stomach and duodenum of humans, while nasal or rectal vaccination is less suitable for this purpose...
  11. doi request reprint CD8- natural killer cells are greatly enriched in the human gastrointestinal tract and have the capacity to respond to bacteria
    Asa Lindgren
    Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden asa lindgren microbio gu se
    J Innate Immun 2:294-302. 2010
    ..These findings may have important implications for the understanding of NK cell subsets and the innate defense against gastrointestinal bacterial infections...
  12. pmc Oral immunization with a Salmonella enterica serovar typhi vaccine induces specific circulating mucosa-homing CD4(+) and CD8(+) T cells in humans
    B Samuel Lundin
    Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute, Goteborg University, 40530 Goteborg, Sweden
    Infect Immun 70:5622-7. 2002
    ..In conclusion, we demonstrate that oral vaccination with a live oral bacterial vaccine induces antigen-specific CD4(+) and CD8(+) memory T cells, almost all of which express the gut-homing integrin beta(7)...
  13. pmc HpaA is essential for Helicobacter pylori colonization in mice
    Elisabet Carlsohn
    Department of Medical Biochemistry, Goteborg University, Box 440, 405 30 Goteborg, Sweden
    Infect Immun 74:920-6. 2006
    ..pylori-infected mice, the HpaA mutant strain was not able to establish colonization. Thus, by combining proteomic analysis and in vivo studies, we conclude that HpaA is essential for the colonization of H. pylori in mice...
  14. pmc Mucosal FOXP3-expressing CD4+ CD25high regulatory T cells in Helicobacter pylori-infected patients
    Anna Lundgren
    Dept of Medical Microbiology and Immunology, Goteborg University, Box 435, 405 30 Goteborg, Sweden
    Infect Immun 73:523-31. 2005
    ..These findings suggest that regulatory T cells may suppress mucosal immune responses and thereby contribute to the persistence of H. pylori infections...
  15. doi request reprint Comparison of mucosal B- and T-cell responses in Helicobacter pylori-infected subjects in a developing and a developed country
    Taufiqur Rahman Bhuiyan
    Department of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    FEMS Immunol Med Microbiol 54:70-9. 2008
    ..pylori, compared with Swedish volunteers. Increased inflammation is present in the duodenum of Bangladeshi volunteers, maybe as a result of frequent exposure to enteric infections in these individuals...
  16. doi request reprint Construction of a non-toxigenic Escherichia coli oral vaccine strain expressing large amounts of CS6 and inducing strong intestinal and serum anti-CS6 antibody responses in mice
    Joshua Tobias
    University of Gothenburg Vaccine Research Institute, and WHO Collaborating Center for Research on Enterotoxigenic Escherichia coli, Department of Microbiology and Immunology, The Sahlgrenska Academy of University of Gothenburg, S 40530 Gothenburg, Sweden
    Vaccine 29:8863-9. 2011
    ..Our data indicate that the described phenol-inactivated non-toxigenic and CS6 over-expressing E. coli strain may be a useful component in an oral ETEC vaccine...
  17. doi request reprint Over-expression of major colonization factors of enterotoxigenic Escherichia coli, alone or together, on non-toxigenic E. coli bacteria
    Joshua Tobias
    University of Gothenburg Vaccine Research Institute, Department of Microbiology and Immunology, The Sahlgrenska Academy of University of Gothenburg, Gothenburg, Sweden
    Vaccine 28:6977-84. 2010
    ..We conclude that the described type of recombinant bacteria over-expressing major CFs of ETEC, alone or in combination, may be useful as candidate strains for use in an oral whole-cell CF-ETEC vaccine...
  18. pmc Helicobacter pylori-specific CD4+ T cells home to and accumulate in the human Helicobacter pylori-infected gastric mucosa
    Anna Lundgren
    Department of Medical Microbiology and Immunology, Goteborg University, 40530 Goteborg, Sweden
    Infect Immun 73:5612-9. 2005
    ..In conclusion, these results suggest that H. pylori-specific CD4(+) T cells preferentially home to and accumulate in the infected stomach and that L-selectin and CCR4/MDC are important for this recruitment...
  19. doi request reprint Construction of non-toxic Escherichia coli and Vibrio cholerae strains expressing high and immunogenic levels of enterotoxigenic E. coli colonization factor I fimbriae
    Joshua Tobias
    Institute of Biomedicine, Department of Microbiology and Immunology, The Sahlgrenska Academy of Göteborg University, S 40530 Göteborg, Sweden
    Vaccine 26:743-52. 2008
    ..cholerae bacteria also induce strong CFA/I-specific serum IgA and IgG+M responses. We conclude that our constructs may be useful as candidate strains in an oral killed CF-ETEC vaccine...
  20. pmc Helicobacter pylori-specific CD4+ CD25high regulatory T cells suppress memory T-cell responses to H. pylori in infected individuals
    Anna Lundgren
    Department of Medical Microbiology and Immunology, Göteborg University Vaccine Research Institute GUVAX, Goteborg University, 405 30 Goteborg, Sweden
    Infect Immun 71:1755-62. 2003
    ..In conclusion, we have shown that H. pylori-infected individuals have impaired memory CD4+ T-cell responses to H. pylori that are linked to the presence of H. pylori-specific regulatory T cells that actively suppress the responses...
  21. pmc Natural killer cells and Helicobacter pylori infection: bacterial antigens and interleukin-12 act synergistically to induce gamma interferon production
    Cheol H Yun
    Department of Medical Microbiology and Immunology and Göteborg University Vaccine Institute GUVAX, Goteborg University, Box 435, 40530 Goteborg, Sweden
    Infect Immun 73:1482-90. 2005
    ..pylori antigen and IL-12. We propose that NK cells play an active role in the local immune response to H. pylori infection...
  22. doi request reprint Immune responses against Helicobacter pylori in gastric cancer patients and in risk groups for gastric cancer
    Jenni Adamsson
    Department of Microbiology and Immunology, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    Helicobacter 18:73-82. 2013
    ..pylori may be associated with risk of gastric cancer (GC) development. To search for potential immunologic markers for GC, we analyzed antibody responses against H. pylori in risk groups of cancer development...
  23. ncbi request reprint BAFF, stimulatory DNA and IL-15 stimulates IgA(+) memory B cells and provides a novel approach for analysis of memory responses to mucosal vaccines
    Sara Tengvall
    Department of Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, University of Gothenburg, Medicinaregatan 7A, Box 435, 405 30 Gothenburg, Sweden
    Vaccine 28:5445-50. 2010
    ..We also show that stimulated IgA memory B cells do not secrete IgA unless they reencounter the specific antigen...
  24. doi request reprint Prevalence, seasonality and severity of disease caused by pathogenic Escherichia coli in children with diarrhoea in Bolivia
    Lucia Gonzales
    1Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Box 435, 405 30 Gothenburg, Sweden
    J Med Microbiol 62:1697-706. 2013
    ..ETEC, EPEC and EAEC are commonly found in Bolivia and may cause severe disease in children. ..
  25. pmc Enterotoxigenic Escherichia coli with STh and STp genotypes is associated with diarrhea both in children in areas of endemicity and in travelers
    Ingrid Bolin
    Department of Microbiology and Immunology, and Göteborg Vaccine Research Institute GUVAX, Goteborg University, Goteborg, Sweden
    J Clin Microbiol 44:3872-7. 2006
    ..Irrespective of ST genotype, the disease symptoms were also similar in both children and travelers...
  26. pmc The major subunit, CfaB, of colonization factor antigen i from enterotoxigenic Escherichia coli is a glycosphingolipid binding protein
    Lena Jansson
    Department of Medical Biochemistry, Institute of Biomedicine, Goteborg University, P O Box 440, S 405 30 Goteborg, Sweden
    Infect Immun 74:3488-97. 2006
    ..coli expressing CFA/I in the absence of tip protein CfaE, as well as by purified fimbriae from the same strain. This demonstrates that the glycosphingolipid-binding capacity of CFA/I resides in the major CfaB subunit...
  27. ncbi request reprint Mutations in the periplasmic chaperone leading to loss of surface expression of the colonization factor CS6 in enterotoxigenic Escherichia coli (ETEC) clinical isolates
    Matilda Nicklasson
    Department of Microbiology and Immunology, Institute of Biomedicine, Goteborg University, P O Box 435, 405 30 Goteborg, Sweden
    Microb Pathog 44:246-54. 2008
    ..The study emphasizes the importance of using both genotypic and phenotypic methods in epidemiological studies of ETEC, e.g. for vaccine development...
  28. ncbi request reprint B cells pulsed with Helicobacter pylori antigen efficiently activate memory CD8+ T cells from H. pylori-infected individuals
    Josef Azem
    Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, Goteborg University, Box 435, 40530 Goteborg, Sweden
    Clin Immunol 118:284-91. 2006
    ..We conclude that CD8+ T cells do participate in the immune response to H. pylori, and this may have implications for the development of more severe disease outcomes in H. pylori-infected subjects...
  29. pmc Enterotoxigenic Escherichia coli multilocus sequence types in Guatemala and Mexico
    Matilda Nicklasson
    Institute of Biomedicine, Department of Microbiology and Immunology, University of Gothenburg, Box 435, 405 30 Goteborg, Sweden
    Emerg Infect Dis 16:143-6. 2010
    ..US travelers to these countries and resident children in Guatemala were infected by ETEC strains of sequence type 398, expressing STp and carrying genetically identical CS6 sequences...
  30. doi request reprint Impaired IFN-γ production after stimulation with bacterial components by natural killer cells from gastric cancer patients
    Asa Lindgren
    Institute of Biomedicine, Department of Microbiology and Immunology, and Mucosal Immunobiology and Vaccine Institute for Strategic Research, University of Gothenburg, Box 435, 405 30 Gothenburg, Sweden
    Exp Cell Res 317:849-58. 2011
    ..In addition, we propose that the observed suppression is due to tumour-derived TGF-β and that increased expression of the transcription factor GATA-3 may be responsible for the TGF-β induced suppression...
  31. doi request reprint Role of different genes in the CS6 operon for surface expression of Enterotoxigenic Escherichia coli colonization factor CS6
    Joshua Tobias
    WHO Collaborating Centre for Research on Enterotoxigenic Escherichia coli ETEC, and Department of Microbiology and Immunology, Institute of Biomedicine, Goteborg University, 40530 Goteborg, Sweden
    Vaccine 26:5373-80. 2008
    ..These findings may have important implications for the construction of strains expressing high levels of CS6 on the surface for eventual use in an ETEC vaccine...
  32. ncbi request reprint Dendritic cells express CCR7 and migrate in response to CCL19 (MIP-3beta) after exposure to Helicobacter pylori
    Malin Hansson
    Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, Goteborg University, Box 435, 405 30 Goteborg, Sweden
    Microbes Infect 8:841-50. 2006
    ..pylori stimulated DC in vitro that may contribute to chronic gastritis in vivo, and our results suggest that H. pylori induces maturation and migration of DC to lymph nodes where they promote T cell responses...
  33. ncbi request reprint Oral immunization with HpaA affords therapeutic protective immunity against H. pylori that is reflected by specific mucosal immune responses
    Johanna Nyström
    Department of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy of Göteborg University, Box 435, 405 30 Goteborg, Sweden
    Vaccine 25:2591-8. 2007
    ..These findings suggest that HpaA is a promising vaccine candidate antigen for use in a therapeutic vaccine against H. pylori...
  34. pmc Molecular characterization of enterotoxigenic Escherichia coli isolates recovered from children with diarrhea during a 4-year period (2007 to 2010) in Bolivia
    Lucia Gonzales
    Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
    J Clin Microbiol 51:1219-25. 2013
    ..A minor seasonal peak of ETEC infections was identified in May during the cold-dry season and coincided with the peak of rotavirus infections; this pattern is unusual for ETEC and may be important for vaccination strategies in Bolivia...
  35. ncbi request reprint Enterotoxins, colonization factors, serotypes and antimicrobial resistance of enterotoxigenic Escherichia coli (ETEC) strains isolated from hospitalized children with diarrhea in Bolivia
    Claudia Rodas
    Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Sweden
    Braz J Infect Dis 15:132-7. 2011
    ..Enterotoxigenic Escherichia coli (ETEC) is recognized as the main cause of bacterial diarrhoea among children in Asia, Africa and Latin America but less investigated in Bolivia...
  36. doi request reprint Different kinetics of circulating antibody-secreting cell responses after primary and booster oral immunizations: a tool for assessing immunological memory
    Susannah Leach
    Gothenburg University Vaccine Research Institute GUVAX, Department of Microbiology and Immunology, University of Gothenburg, Sweden
    Vaccine 31:3035-8. 2013
    ..The results also suggest that detection of peak ASC responses at an early time point after booster immunization can be used as a simple tool to assess immunological memory...
  37. pmc Expression of colonization factor CS5 of enterotoxigenic Escherichia coli (ETEC) is enhanced in vivo and by the bile component Na glycocholate hydrate
    Matilda Nicklasson
    Institute of Biomedicine, Department of Microbiology and Immunology, University of Gothenburg, Goteborg, Sweden
    PLoS ONE 7:e35827. 2012
    ..Another bile salt, sodium deoxycholate (NaDC), previously reported to induce enteropathogenic virulence, also induced expression of CS5, whereas sodium bicarbonate did not...
  38. pmc T- and B-cell immune responses of patients who had undergone colectomies to oral administration of Salmonella enterica serovar Typhi Ty21a vaccine
    Jan Kilhamn
    Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, Goteborg, Sweden
    Clin Diagn Lab Immunol 10:426-30. 2003
    ....
  39. pmc Development of multiplex PCR assays for detection of enterotoxigenic Escherichia coli colonization factors and toxins
    Claudia Rodas
    Department of Microbiology and Immunology, WHO Collaborating Centre for Research on Enterotoxigenic Escherichia coli, Institute of Biomedicine, University of Gothenburg, Goteborg, Sweden
    J Clin Microbiol 47:1218-20. 2009
    ..The assays will be useful for surveillance of ETEC infections in diagnostic laboratories that have access to PCR...
  40. doi request reprint Decreased IgA antibody production in the stomach of gastric adenocarcinoma patients
    Marianne Quiding-Jarbrink
    Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute GUVAX, Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg, Sweden
    Clin Immunol 131:463-71. 2009
    ..We conclude that patients suffering from gastric adenocarcinoma have a dramatically decreased local IgA production in the stomach compared to asymptomatic H. pylori infected individuals...
  41. doi request reprint Strategies to overexpress enterotoxigenic Escherichia coli (ETEC) colonization factors for the construction of oral whole-cell inactivated ETEC vaccine candidates
    Joshua Tobias
    Gothenburg University Vaccine Research Institute GUVAX and Department of Microbiology and Immunology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Appl Microbiol Biotechnol 93:2291-300. 2012
    ..We therefore conclude that our constructs may be useful as candidate strains in an oral whole-cell inactivated CF ETEC vaccine...
  42. doi request reprint Presence of high numbers of transcriptionally active Helicobacter pylori in vomitus from Bangladeshi patients suffering from acute gastroenteritis
    Anders Janzon
    Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Helicobacter 14:237-47. 2009
    ..pylori was quantified in vomitus and diarrheal stool of patients suffering from acute gastroenteritis in Dhaka, Bangladesh...
  43. pmc Failure to detect Helicobacter pylori DNA in drinking and environmental water in Dhaka, Bangladesh, using highly sensitive real-time PCR assays
    Anders Janzon
    Department of Microbiology and Immunology, Sahlgrenska Academy at the University of Gothenburg, Box 435, SE 405 30 Gothenburg, Sweden
    Appl Environ Microbiol 75:3039-44. 2009
    ..Our results suggest that it is unlikely that the predominant transmission route of H. pylori in this area is waterborne...
  44. ncbi request reprint Helicobacter pylori induce neutrophil transendothelial migration: role of the bacterial HP-NAP
    Mikael Brisslert
    Department of Medical Microbiology and Immunology, Goteborg University, Sweden
    FEMS Microbiol Lett 249:95-103. 2005
    ..pylori induced neutrophil transendothelial migration. We propose that HP-NAP contributes to the continuous recruitment of neutrophils to the gastric mucosa of H. pylori infected individuals...
  45. ncbi request reprint Characterization of the outer membrane protein profile from disease-related Helicobacter pylori isolates by subcellular fractionation and nano-LC FT-ICR MS analysis
    Elisabet Carlsohn
    Institute of Biomedicine, Sahlgrenska Academy, Goteborg University, Sweden
    J Proteome Res 5:3197-204. 2006
    ..pylori strains. In addition, presence of Omp30 and absence of Omp6 seemed to be associated with H. pylori strains causing duodenal ulcer...
  46. ncbi request reprint The expression of the Helicobacter pylori genes ureA and nap is higher in vivo than in vitro as measured by quantitative competitive reverse transcriptase-PCR
    Kristina Blom
    Department of Medical Microbiology and Immunology, Goteborg University, P O Box 435, SE 40530, Goteborg, Sweden
    FEMS Immunol Med Microbiol 32:219-26. 2002
    ..The transcription of ureA and nap also differed in that ureA showed highest expression early in infection in mice whereas nap transcription was variable throughout the 18-week infection period...
  47. doi request reprint Construction and expression of immunogenic hybrid enterotoxigenic Escherichia coli CFA/I and CS2 colonization fimbriae for use in vaccines
    Joshua Tobias
    University of Gothenburg Vaccine Research Institute GUVAX, 40530 Gothenburg, Sweden
    Appl Microbiol Biotechnol 87:1355-65. 2010
    ..Bacteria expressing hybrid fimbriae are potential candidate strains in an oral-killed CF-ETEC vaccine, and the approach represents an attractive and novel means of producing a broad-spectrum ETEC vaccine...
  48. ncbi request reprint Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA
    Jan Holmgren
    Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, Goteborg University, P O Box 435, SE 40530 Goteborg, Sweden
    Immunol Lett 97:181-8. 2005
    ..The properties and clinical potential of these different classes of adjuvants are being discussed...
  49. doi request reprint FOXP3-expressing CD4(+) T-cell numbers increase in areas of duodenal gastric metaplasia and are associated to CD4(+) T-cell aggregates in the duodenum of Helicobacter pylori-infected duodenal ulcer patients
    Bert Kindlund
    Department of Microbiology and Immunology, Sahlgrenska Academy, University of Gothenburg and Mucosal Immunobiology and Vaccine Center, Gothenburg, Sweden
    Helicobacter 14:192-201. 2009
    ..We also determined gene expression levels of FOXP3 as well as anti- and proinflammatory cytokines before and after H. pylori eradication...
  50. pmc Sulfatide recognition by colonization factor antigen CS6 from enterotoxigenic Escherichia coli
    Lena Jansson
    Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Goteborg, Sweden
    PLoS ONE 4:e4487. 2009
    ..g. humans and rabbits, but lacking in species not affected by CS6 ETEC, e.g. mice. The ability of CS6-expressing ETEC to adhere to sulfatide in target small intestinal epithelium may thus contribute to virulence...
  51. pmc Enterotoxigenic Escherichia coli isolated from surface water in urban and rural areas of Bangladesh
    Yasmin A Begum
    J Clin Microbiol 43:3582-3. 2005
  52. ncbi request reprint Randomised, double-blind, safety and efficacy of a killed oral vaccine for enterotoxigenic E. Coli diarrhoea of travellers to Guatemala and Mexico
    David A Sack
    Vaccine Testing Unit, Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Vaccine 25:4392-400. 2007
    ..We conclude that the new oral ETEC vaccine reduces the rate of more severe episodes of traveller's diarrhoea (TD) due to VPO-ETEC, but it did not reduce the overall rate of ETEC diarrhoea or of travellers' diarrhoea due to other causes...
  53. ncbi request reprint Antigenic variation within the subunit protein of members of the colonization factor antigen I group of fimbrial proteins in human enterotoxigenic Escherichia coli
    Wim Gaastra
    Department of Infectious Diseases and Immunology, Utrecht University, The Netherlands
    Int J Med Microbiol 292:43-50. 2002
    ..The genetic similarity between CS1, CS17 and CS19 is reflected in the substantial immunological cross-reactivity observed, both between their protein subunits and intact fimbriae...
  54. ncbi request reprint Enterotoxigenic Escherichia coli colonization factor types collected from 1997 to 2001 in US military personnel during operation Bright Star in northern Egypt
    David M Rockabrand
    Naval Medical Research Unit No 3, Cairo, Egypt
    Diagn Microbiol Infect Dis 55:9-12. 2006
    ..However, despite intensive testing, CFs could not be identified in most of the ETEC isolated, highlighting the need for further studies to identify novel CFs and alternative vaccine targets...
  55. ncbi request reprint Introductory evaluation of an oral, killed whole cell enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine in Egyptian infants
    Stephen J Savarino
    US Naval Medical Research Unit Number 3, Cairo, Egypt
    Pediatr Infect Dis J 21:322-30. 2002
    ..We conducted the first trial to assess the safety and immunogenicity of an oral, killed enterotoxigenic Escherichia coli plus cholera toxin B-subunit vaccine in children <2 years old...
  56. pmc Mucosal and systemic immune responses in patients with diarrhea due to CS6-expressing enterotoxigenic Escherichia coli
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPO Box 128, Dhaka 1000, Bangladesh
    Infect Immun 75:2269-74. 2007
    ..Studies are needed to determine if the anti-CS6 responses protect against reinfection and if protective levels of CS6 immunity are induced by vaccination...
  57. pmc Homologous and cross-reactive immune responses to enterotoxigenic Escherichia coli colonization factors in Bangladeshi children
    Firdausi Qadri
    International Centre for Diarhoeal Disease Research, Bangladesh, Laboratory Sciences Division, GPO Box 128, Dhaka 1000, Bangladesh
    Infect Immun 74:4512-8. 2006
    ....
  58. pmc Sensitive microplate assay for detection of bactericidal antibodies to Vibrio cholerae O139
    Stephen R Attridge
    Department of Molecular Biosciences, University of Adelaide, Adelaide, South Australia 5005, Australia
    Clin Diagn Lab Immunol 9:383-7. 2002
    ..Although infection generated stronger responses than vaccination, the proportion of responders was similar among individuals with low background titers...
  59. ncbi request reprint Breast milk reduces the risk of illness in children of mothers with cholera: observations from an epidemic of cholera in Guinea-Bissau
    Katja Qureshi
    Projecto de Saude de Bandim, Bissau, Guinea Bissau
    Pediatr Infect Dis J 25:1163-6. 2006
    ....
  60. pmc High disease burden of diarrhea due to enterotoxigenic Escherichia coli among rural Egyptian infants and young children
    Malla R Rao
    Epidemiology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    J Clin Microbiol 41:4862-4. 2003
    ..The incidence increased from 1.7 episodes per child per year in the first 6 months of life to 2.3 in the second 6 months and declined thereafter...
  61. ncbi request reprint Helicobacter pylori- inflammation, immunity and vaccines
    Pierre Michetti
    Division of Gastroenterology and Hepatology, Lausanne University Medical Center, Lausanne, Switzerland
    Helicobacter 8:31-5. 2003
    ..Finally, progress has been achieved in vaccine development, with new vaccine delivery systems and routes of immunization tested in animal models and human volunteers...
  62. pmc Detection of antibodies to toxin-coregulated pili in sera from cholera patients
    Stephen R Attridge
    Department of Molecular Biosciences, The University of Adelaide, Adelaide, South Australia, Australia
    Infect Immun 72:1824-7. 2004
    ..These MAbs were used in immunoblotting studies to assess seroconversion to El Tor TCP following cholera. Clear anti-pilus responses were observed in five of nine patients...
  63. pmc Enterotoxigenic Escherichia coli in developing countries: epidemiology, microbiology, clinical features, treatment, and prevention
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh
    Clin Microbiol Rev 18:465-83. 2005
    ..Increases in antimicrobial resistance will dictate the drugs used for the treatment of traveler's diarrhea. Efforts need to be made to improve our understanding of the worldwide importance of ETEC...
  64. pmc Enterotoxigenic Escherichia coli and Vibrio cholerae diarrhea, Bangladesh, 2004
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Emerg Infect Dis 11:1104-7. 2005
    ..ETEC that produced heat-stable enterotoxin alone was most prevalent, and 78% of strains had colonization factors. Like V. cholerae O1, ETEC can cause epidemic diarrhea...
  65. pmc Reduction in capsular content and enhanced bacterial susceptibility to serum killing of Vibrio cholerae O139 associated with the 2002 cholera epidemic in Bangladesh
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka
    Infect Immun 73:6577-83. 2005
    ..cholerae O139. Consequently, this assay may be useful in studies of both O139-infected patients and recipients of O139 vaccines...
  66. ncbi request reprint Reduced doses of oral killed enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine is safe and immunogenic in Bangladeshi infants 6-17 months of age: dosing studies in different age groups
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPO Box 128, Dhaka 1000, Bangladesh
    Vaccine 24:1726-33. 2006
    ..05-0.001). This study thus demonstrates that reduced doses of the ETEC vaccine is immunogenic in children and infants as well as safe in infants down to 6 months of age...
  67. ncbi request reprint Serologic correlates of protection against enterotoxigenic Escherichia coli diarrhea
    Malla R Rao
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, Maryland 20910 7500, USA
    J Infect Dis 191:562-70. 2005
    ....
  68. pmc Increased levels of inflammatory mediators in children and adults infected with Vibrio cholerae O1 and O139
    Firdausi Qadri
    Centre for Health and Population Research, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    Clin Diagn Lab Immunol 9:221-9. 2002
    ..cholerae O1 and O139...
  69. pmc Disease burden due to enterotoxigenic Escherichia coli in the first 2 years of life in an urban community in Bangladesh
    Firdausi Qadri
    International Centre for Diarrheal Disease Research, Laboratory Sciences Division B, Dhaka 1000, Bangladesh
    Infect Immun 75:3961-8. 2007
    ..032 to 0.023). Children with ETEC diarrhea were underweight and growth stunted at the 2-year follow-up period, showing the importance of strategies to prevent and decrease ETEC diarrheal morbidity in children...
  70. pmc Phenotypic profiles of enterotoxigenic Escherichia coli associated with early childhood diarrhea in rural Egypt
    Hind I Shaheen
    U S Naval Medical Research Unit Number 3, Cairo, Egypt
    J Clin Microbiol 42:5588-95. 2004
    ....
  71. pmc Cholera due to altered El Tor strains of Vibrio cholerae O1 in Bangladesh
    G Balakrish Nair
    Laboratory Sciences Division, ICDDR, B Centre for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
    J Clin Microbiol 44:4211-3. 2006
    ..All of the El Tor strains of V. cholerae O1 isolated since 2001 produced CT of the classical biotype, while those isolated before 2001 produced CT of the El Tor biotype...