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Species | Ann Mari SvennerholmSummaryCountry: Sweden Publications
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Recent progress toward an enterotoxigenic Escherichia coli vaccineAnn Mari Svennerholm
Gothenburg University Vaccine Research Institute and Department of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Sweden
Expert Rev Vaccines 11:495-507. 2012..They also discuss possibilities of enhancing immune responses to candidate ETEC vaccines, particularly in children...
Priming and expression of immune responses in the gastric mucosaAnn Mari Svennerholm
Department of Medical Microbiology and Immunology, Göteborg University Vaccine Research Institute GUVAX, Goteborg University, P O Box 435, 405 30 Goteborg, Sweden
Microbes Infect 5:731-9. 2003..pylori infection, as well as lymphocyte homing within the common mucosal immune system, and the importance of immunisation route are discussed...
From cholera to enterotoxigenic Escherichia coli (ETEC) vaccine developmentAnn Mari Svennerholm
WHO Collaborating Centre for Research on ETEC and Gothenburg University Vaccine Research Institute GUVAX, Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
Indian J Med Res 133:188-96. 2011..coli strains overexpressing the major CFs and a more LT like hybrid toxoid (LCTBA) has been developed. This vaccine will be tested soon alone and together with a mucosal adjuvant, i.e. dmLT, in clinical trials...- Prospects for a mucosally-administered vaccine against Helicobacter pyloriAnn-Mari Svennerholm
Department of Medical Microbiology and Immunology, , , PO Box 435, 40530, , Sweden
Vaccine 21:347-53. 2003 - Vaccines against enterotoxigenic Escherichia coliAnn Mari Svennerholm
Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, S 40530, Gothenburg, Sweden
Expert Rev Vaccines 7:795-804. 2008..Against this background, intense efforts are in progress to try to improve the immunogenicity of different available candidate vaccines, as well as to develop new types of ETEC vaccines... - Progress in vaccine development against Helicobacter pyloriAnn Mari Svennerholm
Department of Microbiology and Immunology, Institute of Biomedicine, Goteborg University, Goteborg, Sweden
FEMS Immunol Med Microbiol 50:146-56. 2007..pylori as well as to identify a cocktail of strong protective antigens, or recombinant bacterial strains that express such antigens, that could be administered by a regimen that gives rise to effective immune responses in humans... - Microbial-gut interactions in health and disease. Progress in enteric vaccine developmentAnn Mari Svennerholm
Department of Medical Microbiology and Immunology, and Göteborg University Vaccine Institute GUVAX, Goteborg University, P O Box 435, Goteborg S 405 30, Sweden
Best Pract Res Clin Gastroenterol 18:421-45. 2004..In this chapter we describe the properties and availability of the recently licensed vaccines and present an update on the diverse efforts being made to achieve new or improved vaccines against the most prevalent enteropathogens... - The local and systemic T-cell response to Helicobacter pylori in gastric cancer patients is characterised by production of interleukin-10B Samuel Lundin
Department of Microbiology and Immunology, Institute of Biomedicine, Göteborg University Vaccine Research Institute, Goteborg University, Goteborg, Sweden
Clin Immunol 125:205-13. 2007..pylori-infected GC patients leads to a diminished cytotoxic anti-tumour T-cell response in the stomach, which may contribute to tumour progression in subjects suffering from GC... - Comparison of different routes of vaccination for eliciting antibody responses in the human stomachEva Liz Johansson
Department of Medical Microbiology and Immunology, Göteborg University Vaccine Institute, Goteborg University, Box 435, SE 405 30 Goteborg, Sweden
Vaccine 22:984-90. 2004..We conclude that oral vaccination is the optimal route for induction of antigen-specific IgA antibody responses in the stomach and duodenum of humans, while nasal or rectal vaccination is less suitable for this purpose... - In vivo expression of the heat stable (estA) and heat labile (eltB) toxin genes of enterotoxigenic Escherichia coli (ETEC)Asa Sjoling
Institute of Biomedicine, Department of Microbiology and Immunology, Goteborg University, Box 435, 405 30 Goteborg, Sweden
Microbes Infect 8:2797-802. 2006..We found that estA and eltB are expressed in the in vivo samples but no significant up-or down regulation of the expression levels of either estA or eltB could be determined in vivo as compared to in vitro... - Oral immunization with a Salmonella enterica serovar typhi vaccine induces specific circulating mucosa-homing CD4(+) and CD8(+) T cells in humansB Samuel Lundin
Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute, Goteborg University, 40530 Goteborg, Sweden
Infect Immun 70:5622-7. 2002..In conclusion, we demonstrate that oral vaccination with a live oral bacterial vaccine induces antigen-specific CD4(+) and CD8(+) memory T cells, almost all of which express the gut-homing integrin beta(7)... - CD8- natural killer cells are greatly enriched in the human gastrointestinal tract and have the capacity to respond to bacteriaAsa Lindgren
Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden asa lindgren microbio gu se
J Innate Immun 2:294-302. 2010..These findings may have important implications for the understanding of NK cell subsets and the innate defense against gastrointestinal bacterial infections... - HpaA is essential for Helicobacter pylori colonization in miceElisabet Carlsohn
Department of Medical Biochemistry, Goteborg University, Box 440, 405 30 Goteborg, Sweden
Infect Immun 74:920-6. 2006..pylori-infected mice, the HpaA mutant strain was not able to establish colonization. Thus, by combining proteomic analysis and in vivo studies, we conclude that HpaA is essential for the colonization of H. pylori in mice... - Comparison of mucosal B- and T-cell responses in Helicobacter pylori-infected subjects in a developing and a developed countryTaufiqur Rahman Bhuiyan
Department of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
FEMS Immunol Med Microbiol 54:70-9. 2008..pylori, compared with Swedish volunteers. Increased inflammation is present in the duodenum of Bangladeshi volunteers, maybe as a result of frequent exposure to enteric infections in these individuals... - Mucosal FOXP3-expressing CD4+ CD25high regulatory T cells in Helicobacter pylori-infected patientsAnna Lundgren
Dept of Medical Microbiology and Immunology, Goteborg University, Box 435, 405 30 Goteborg, Sweden
Infect Immun 73:523-31. 2005..These findings suggest that regulatory T cells may suppress mucosal immune responses and thereby contribute to the persistence of H. pylori infections... - Construction of a non-toxigenic Escherichia coli oral vaccine strain expressing large amounts of CS6 and inducing strong intestinal and serum anti-CS6 antibody responses in miceJoshua Tobias
University of Gothenburg Vaccine Research Institute, and WHO Collaborating Center for Research on Enterotoxigenic Escherichia coli, Department of Microbiology and Immunology, The Sahlgrenska Academy of University of Gothenburg, S 40530 Gothenburg, Sweden
Vaccine 29:8863-9. 2011..Our data indicate that the described phenol-inactivated non-toxigenic and CS6 over-expressing E. coli strain may be a useful component in an oral ETEC vaccine... - Construction of non-toxic Escherichia coli and Vibrio cholerae strains expressing high and immunogenic levels of enterotoxigenic E. coli colonization factor I fimbriaeJoshua Tobias
Institute of Biomedicine, Department of Microbiology and Immunology, The Sahlgrenska Academy of Göteborg University, S 40530 Göteborg, Sweden
Vaccine 26:743-52. 2008..cholerae bacteria also induce strong CFA/I-specific serum IgA and IgG+M responses. We conclude that our constructs may be useful as candidate strains in an oral killed CF-ETEC vaccine... - Helicobacter pylori-specific CD4+ T cells home to and accumulate in the human Helicobacter pylori-infected gastric mucosaAnna Lundgren
Department of Medical Microbiology and Immunology, Goteborg University, 40530 Goteborg, Sweden
Infect Immun 73:5612-9. 2005..In conclusion, these results suggest that H. pylori-specific CD4(+) T cells preferentially home to and accumulate in the infected stomach and that L-selectin and CCR4/MDC are important for this recruitment... - Natural killer cells and Helicobacter pylori infection: bacterial antigens and interleukin-12 act synergistically to induce gamma interferon productionCheol H Yun
Department of Medical Microbiology and Immunology and Göteborg University Vaccine Institute GUVAX, Goteborg University, Box 435, 40530 Goteborg, Sweden
Infect Immun 73:1482-90. 2005..pylori antigen and IL-12. We propose that NK cells play an active role in the local immune response to H. pylori infection... - Over-expression of major colonization factors of enterotoxigenic Escherichia coli, alone or together, on non-toxigenic E. coli bacteriaJoshua Tobias
University of Gothenburg Vaccine Research Institute, Department of Microbiology and Immunology, The Sahlgrenska Academy of University of Gothenburg, Gothenburg, Sweden
Vaccine 28:6977-84. 2010..We conclude that the described type of recombinant bacteria over-expressing major CFs of ETEC, alone or in combination, may be useful as candidate strains for use in an oral whole-cell CF-ETEC vaccine... - Mutations in the periplasmic chaperone leading to loss of surface expression of the colonization factor CS6 in enterotoxigenic Escherichia coli (ETEC) clinical isolatesMatilda Nicklasson
Department of Microbiology and Immunology, Institute of Biomedicine, Goteborg University, P O Box 435, 405 30 Goteborg, Sweden
Microb Pathog 44:246-54. 2008..The study emphasizes the importance of using both genotypic and phenotypic methods in epidemiological studies of ETEC, e.g. for vaccine development... - Dendritic cells express CCR7 and migrate in response to CCL19 (MIP-3beta) after exposure to Helicobacter pyloriMalin Hansson
Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, Goteborg University, Box 435, 405 30 Goteborg, Sweden
Microbes Infect 8:841-50. 2006..pylori stimulated DC in vitro that may contribute to chronic gastritis in vivo, and our results suggest that H. pylori induces maturation and migration of DC to lymph nodes where they promote T cell responses... - BAFF, stimulatory DNA and IL-15 stimulates IgA(+) memory B cells and provides a novel approach for analysis of memory responses to mucosal vaccinesSara Tengvall
Department of Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, University of Gothenburg, Medicinaregatan 7A, Box 435, 405 30 Gothenburg, Sweden
Vaccine 28:5445-50. 2010..We also show that stimulated IgA memory B cells do not secrete IgA unless they reencounter the specific antigen... - Enterotoxigenic Escherichia coli with STh and STp genotypes is associated with diarrhea both in children in areas of endemicity and in travelersIngrid Bolin
Department of Microbiology and Immunology, and Göteborg Vaccine Research Institute GUVAX, Goteborg University, Goteborg, Sweden
J Clin Microbiol 44:3872-7. 2006..Irrespective of ST genotype, the disease symptoms were also similar in both children and travelers... - Impaired IFN-γ production after stimulation with bacterial components by natural killer cells from gastric cancer patientsAsa Lindgren
Institute of Biomedicine, Department of Microbiology and Immunology, and Mucosal Immunobiology and Vaccine Institute for Strategic Research, University of Gothenburg, Box 435, 405 30 Gothenburg, Sweden
Exp Cell Res 317:849-58. 2011..In addition, we propose that the observed suppression is due to tumour-derived TGF-β and that increased expression of the transcription factor GATA-3 may be responsible for the TGF-β induced suppression... - Enterotoxigenic Escherichia coli multilocus sequence types in Guatemala and MexicoMatilda Nicklasson
Institute of Biomedicine, Department of Microbiology and Immunology, University of Gothenburg, Box 435, 405 30 Goteborg, Sweden
Emerg Infect Dis 16:143-6. 2010..US travelers to these countries and resident children in Guatemala were infected by ETEC strains of sequence type 398, expressing STp and carrying genetically identical CS6 sequences... - Oral immunization with HpaA affords therapeutic protective immunity against H. pylori that is reflected by specific mucosal immune responsesJohanna Nyström
Department of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy of Göteborg University, Box 435, 405 30 Goteborg, Sweden
Vaccine 25:2591-8. 2007..These findings suggest that HpaA is a promising vaccine candidate antigen for use in a therapeutic vaccine against H. pylori... - Role of different genes in the CS6 operon for surface expression of Enterotoxigenic Escherichia coli colonization factor CS6Joshua Tobias
WHO Collaborating Centre for Research on Enterotoxigenic Escherichia coli ETEC, and Department of Microbiology and Immunology, Institute of Biomedicine, Goteborg University, 40530 Goteborg, Sweden
Vaccine 26:5373-80. 2008..These findings may have important implications for the construction of strains expressing high levels of CS6 on the surface for eventual use in an ETEC vaccine... - Enterotoxins, colonization factors, serotypes and antimicrobial resistance of enterotoxigenic Escherichia coli (ETEC) strains isolated from hospitalized children with diarrhea in BoliviaClaudia Rodas
Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Sweden
Braz J Infect Dis 15:132-7. 2011..Presence of CFs was associated with antibiotic resistance. CONCLUSION: The most common toxin profile was LT 70%, LT/STh 23% and STh 7%. High antimicrobial resistance to ampicillin among serogroups O6, O8 and O78 were the most common... - Expression of colonization factor CS5 of enterotoxigenic Escherichia coli (ETEC) is enhanced in vivo and by the bile component Na glycocholate hydrateMatilda Nicklasson
Institute of Biomedicine, Department of Microbiology and Immunology, University of Gothenburg, Goteborg, Sweden
PLoS ONE 7:e35827. 2012..Another bile salt, sodium deoxycholate (NaDC), previously reported to induce enteropathogenic virulence, also induced expression of CS5, whereas sodium bicarbonate did not... - T- and B-cell immune responses of patients who had undergone colectomies to oral administration of Salmonella enterica serovar Typhi Ty21a vaccineJan Kilhamn
Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, Goteborg, Sweden
Clin Diagn Lab Immunol 10:426-30. 2003.... - Helicobacter pylori induce neutrophil transendothelial migration: role of the bacterial HP-NAPMikael Brisslert
Department of Medical Microbiology and Immunology, Goteborg University, Sweden
FEMS Microbiol Lett 249:95-103. 2005..pylori induced neutrophil transendothelial migration. We propose that HP-NAP contributes to the continuous recruitment of neutrophils to the gastric mucosa of H. pylori infected individuals... - Decreased IgA antibody production in the stomach of gastric adenocarcinoma patientsMarianne Quiding-Jarbrink
Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute GUVAX, Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg, Sweden
Clin Immunol 131:463-71. 2009..We conclude that patients suffering from gastric adenocarcinoma have a dramatically decreased local IgA production in the stomach compared to asymptomatic H. pylori infected individuals... - Development of multiplex PCR assays for detection of enterotoxigenic Escherichia coli colonization factors and toxinsClaudia Rodas
Department of Microbiology and Immunology, WHO Collaborating Centre for Research on Enterotoxigenic Escherichia coli, Institute of Biomedicine, University of Gothenburg, Goteborg, Sweden
J Clin Microbiol 47:1218-20. 2009..The assays will be useful for surveillance of ETEC infections in diagnostic laboratories that have access to PCR... - B cells pulsed with Helicobacter pylori antigen efficiently activate memory CD8+ T cells from H. pylori-infected individualsJosef Azem
, , Box 435, , Sweden
Clin Immunol 118:284-91. 2006..We conclude that CD8+ T cells do participate in the immune response to H. pylori, and this may have implications for the development of more severe disease outcomes in H. pylori-infected subjects... - Strategies to overexpress enterotoxigenic Escherichia coli (ETEC) colonization factors for the construction of oral whole-cell inactivated ETEC vaccine candidatesJoshua Tobias
Gothenburg University Vaccine Research Institute GUVAX and Department of Microbiology and Immunology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Appl Microbiol Biotechnol 93:2291-300. 2012..We therefore conclude that our constructs may be useful as candidate strains in an oral whole-cell inactivated CF ETEC vaccine... - Presence of high numbers of transcriptionally active Helicobacter pylori in vomitus from Bangladeshi patients suffering from acute gastroenteritisAnders Janzon
Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Helicobacter 14:237-47. 2009..pylori was quantified in vomitus and diarrheal stool of patients suffering from acute gastroenteritis in Dhaka, Bangladesh... - Characterization of the outer membrane protein profile from disease-related Helicobacter pylori isolates by subcellular fractionation and nano-LC FT-ICR MS analysisElisabet Carlsohn
Institute of Biomedicine, Sahlgrenska Academy, Goteborg University, Sweden
J Proteome Res 5:3197-204. 2006..pylori strains. In addition, presence of Omp30 and absence of Omp6 seemed to be associated with H. pylori strains causing duodenal ulcer... - Failure to detect Helicobacter pylori DNA in drinking and environmental water in Dhaka, Bangladesh, using highly sensitive real-time PCR assaysAnders Janzon
Department of Microbiology and Immunology, Sahlgrenska Academy at the University of Gothenburg, Box 435, SE 405 30 Gothenburg, Sweden
Appl Environ Microbiol 75:3039-44. 2009..Our results suggest that it is unlikely that the predominant transmission route of H. pylori in this area is waterborne... - Helicobacter pylori-specific CD4+ CD25high regulatory T cells suppress memory T-cell responses to H. pylori in infected individualsAnna Lundgren
Department of Medical Microbiology and Immunology, , , , Sweden
Infect Immun 71:1755-62. 2003..In conclusion, we have shown that H. pylori-infected individuals have impaired memory CD4+ T-cell responses to H. pylori that are linked to the presence of H. pylori-specific regulatory T cells that actively suppress the responses... - Immune responses against Helicobacter pylori in gastric cancer patients and in risk groups for gastric cancerJenni Adamsson
Department of Microbiology and Immunology, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
Helicobacter 18:73-82. 2013..pylori may be associated with risk of gastric cancer (GC) development. To search for potential immunologic markers for GC, we analyzed antibody responses against H. pylori in risk groups of cancer development... - Construction and expression of immunogenic hybrid enterotoxigenic Escherichia coli CFA/I and CS2 colonization fimbriae for use in vaccinesJoshua Tobias
University of Gothenburg Vaccine Research Institute GUVAX, 40530 Gothenburg, Sweden
Appl Microbiol Biotechnol 87:1355-65. 2010..Bacteria expressing hybrid fimbriae are potential candidate strains in an oral-killed CF-ETEC vaccine, and the approach represents an attractive and novel means of producing a broad-spectrum ETEC vaccine... - The expression of the Helicobacter pylori genes ureA and nap is higher in vivo than in vitro as measured by quantitative competitive reverse transcriptase-PCRKristina Blom
Department of Medical Microbiology and Immunology, , P.O. Box 435, SE-40530, , Sweden
FEMS Immunol Med Microbiol 32:219-26. 2002..The transcription of ureA and nap also differed in that ureA showed highest expression early in infection in mice whereas nap transcription was variable throughout the 18-week infection period... - Molecular characterization of enterotoxigenic Escherichia coli isolates recovered from children with diarrhea during a 4-year period (2007 to 2010) in BoliviaLucia Gonzales
Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
J Clin Microbiol 51:1219-25. 2013..A minor seasonal peak of ETEC infections was identified in May during the cold-dry season and coincided with the peak of rotavirus infections; this pattern is unusual for ETEC and may be important for vaccination strategies in Bolivia... - FOXP3-expressing CD4(+) T-cell numbers increase in areas of duodenal gastric metaplasia and are associated to CD4(+) T-cell aggregates in the duodenum of Helicobacter pylori-infected duodenal ulcer patientsBert Kindlund
Department of Microbiology and Immunology, Sahlgrenska Academy, University of Gothenburg and Mucosal Immunobiology and Vaccine Center, Gothenburg, Sweden
Helicobacter 14:192-201. 2009..We also determined gene expression levels of FOXP3 as well as anti- and proinflammatory cytokines before and after H. pylori eradication... - Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNAJan Holmgren
Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, Goteborg University, P O Box 435, SE 40530 Goteborg, Sweden
Immunol Lett 97:181-8. 2005..The properties and clinical potential of these different classes of adjuvants are being discussed... - Sulfatide recognition by colonization factor antigen CS6 from enterotoxigenic Escherichia coliLena Jansson
Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Goteborg, Sweden
PLoS ONE 4:e4487. 2009..g. humans and rabbits, but lacking in species not affected by CS6 ETEC, e.g. mice. The ability of CS6-expressing ETEC to adhere to sulfatide in target small intestinal epithelium may thus contribute to virulence... - The major subunit, CfaB, of colonization factor antigen i from enterotoxigenic Escherichia coli is a glycosphingolipid binding proteinLena Jansson
Department of Medical Biochemistry, Institute of Biomedicine, , P.O. Box 440, , Sweden
Infect Immun 74:3488-97. 2006..coli expressing CFA/I in the absence of tip protein CfaE, as well as by purified fimbriae from the same strain. This demonstrates that the glycosphingolipid-binding capacity of CFA/I resides in the major CfaB subunit... - Sensitive microplate assay for detection of bactericidal antibodies to Vibrio cholerae O139Stephen R Attridge
Department of Molecular Biosciences, University of Adelaide, Adelaide, South Australia 5005, Australia
Clin Diagn Lab Immunol 9:383-7. 2002..Although infection generated stronger responses than vaccination, the proportion of responders was similar among individuals with low background titers... - Detection of antibodies to toxin-coregulated pili in sera from cholera patientsStephen R Attridge
Department of Molecular Biosciences, The University of Adelaide, Adelaide, South Australia, Australia
Infect Immun 72:1824-7. 2004..These MAbs were used in immunoblotting studies to assess seroconversion to El Tor TCP following cholera. Clear anti-pilus responses were observed in five of nine patients... - Helicobacter pylori- inflammation, immunity and vaccinesPierre Michetti
Division of Gastroenterology and Hepatology, Lausanne University Medical Center, Lausanne, Switzerland
Helicobacter 8:31-5. 2003..Finally, progress has been achieved in vaccine development, with new vaccine delivery systems and routes of immunization tested in animal models and human volunteers... - Cholera due to altered El Tor strains of Vibrio cholerae O1 in BangladeshG Balakrish Nair
Laboratory Sciences Division, ICDDR, B Centre for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
J Clin Microbiol 44:4211-3. 2006..All of the El Tor strains of V. cholerae O1 isolated since 2001 produced CT of the classical biotype, while those isolated before 2001 produced CT of the El Tor biotype... - High disease burden of diarrhea due to enterotoxigenic Escherichia coli among rural Egyptian infants and young childrenMalla R Rao
Epidemiology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
J Clin Microbiol 41:4862-4. 2003..The incidence increased from 1.7 episodes per child per year in the first 6 months of life to 2.3 in the second 6 months and declined thereafter... - Introductory evaluation of an oral, killed whole cell enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine in Egyptian infantsStephen J Savarino
US Naval Medical Research Unit Number 3, Cairo, Egypt
Pediatr Infect Dis J 21:322-30. 2002..We conducted the first trial to assess the safety and immunogenicity of an oral, killed enterotoxigenic Escherichia coli plus cholera toxin B-subunit vaccine in children <2 years old... - Antigenic variation within the subunit protein of members of the colonization factor antigen I group of fimbrial proteins in human enterotoxigenic Escherichia coliWim Gaastra
Department of Infectious Diseases and Immunology, Utrecht University, The Netherlands
Int J Med Microbiol 292:43-50. 2002..The genetic similarity between CS1, CS17 and CS19 is reflected in the substantial immunological cross-reactivity observed, both between their protein subunits and intact fimbriae... - Phenotypic profiles of enterotoxigenic Escherichia coli associated with early childhood diarrhea in rural EgyptHind I Shaheen
U.S. Naval Medical Research Unit Number 3, Cairo, Egypt
J Clin Microbiol 42:5588-95. 2004.... - Increased levels of inflammatory mediators in children and adults infected with Vibrio cholerae O1 and O139Firdausi Qadri
Centre for Health and Population Research, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
Clin Diagn Lab Immunol 9:221-9. 2002..cholerae O1 and O139... - Mucosal and systemic immune responses in patients with diarrhea due to CS6-expressing enterotoxigenic Escherichia coliFirdausi Qadri
International Centre for Diarrhoeal Disease Research, Bangladesh, GPO Box 128, Dhaka 1000, Bangladesh
Infect Immun 75:2269-74. 2007..Studies are needed to determine if the anti-CS6 responses protect against reinfection and if protective levels of CS6 immunity are induced by vaccination... - Randomised, double-blind, safety and efficacy of a killed oral vaccine for enterotoxigenic E. Coli diarrhoea of travellers to Guatemala and MexicoDavid A Sack
Vaccine Testing Unit, Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Vaccine 25:4392-400. 2007..We conclude that the new oral ETEC vaccine reduces the rate of more severe episodes of traveller's diarrhoea (TD) due to VPO-ETEC, but it did not reduce the overall rate of ETEC diarrhoea or of travellers' diarrhoea due to other causes... - Disease burden due to enterotoxigenic Escherichia coli in the first 2 years of life in an urban community in BangladeshFirdausi Qadri
International Centre for Diarrheal Disease Research, Laboratory Sciences Division B, Dhaka 1000, Bangladesh
Infect Immun 75:3961-8. 2007..032 to 0.023). Children with ETEC diarrhea were underweight and growth stunted at the 2-year follow-up period, showing the importance of strategies to prevent and decrease ETEC diarrheal morbidity in children... - Homologous and cross-reactive immune responses to enterotoxigenic Escherichia coli colonization factors in Bangladeshi childrenFirdausi Qadri
International Centre for Diarhoeal Disease Research, Bangladesh, Laboratory Sciences Division, GPO Box 128, Dhaka 1000, Bangladesh
Infect Immun 74:4512-8. 2006.... - Enterotoxigenic Escherichia coli colonization factor types collected from 1997 to 2001 in US military personnel during operation Bright Star in northern EgyptDavid M Rockabrand
Naval Medical Research Unit No 3, Cairo, Egypt
Diagn Microbiol Infect Dis 55:9-12. 2006..However, despite intensive testing, CFs could not be identified in most of the ETEC isolated, highlighting the need for further studies to identify novel CFs and alternative vaccine targets... - Reduced doses of oral killed enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine is safe and immunogenic in Bangladeshi infants 6-17 months of age: dosing studies in different age groupsFirdausi Qadri
International Centre for Diarrhoeal Disease Research, Bangladesh, GPO Box 128, Dhaka 1000, Bangladesh
Vaccine 24:1726-33. 2006..05-0.001). This study thus demonstrates that reduced doses of the ETEC vaccine is immunogenic in children and infants as well as safe in infants down to 6 months of age... - Reduction in capsular content and enhanced bacterial susceptibility to serum killing of Vibrio cholerae O139 associated with the 2002 cholera epidemic in BangladeshFirdausi Qadri
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka
Infect Immun 73:6577-83. 2005..cholerae O139. Consequently, this assay may be useful in studies of both O139-infected patients and recipients of O139 vaccines... - Enterotoxigenic Escherichia coli and Vibrio cholerae diarrhea, Bangladesh, 2004Firdausi Qadri
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
Emerg Infect Dis 11:1104-7. 2005..ETEC that produced heat-stable enterotoxin alone was most prevalent, and 78% of strains had colonization factors. Like V. cholerae O1, ETEC can cause epidemic diarrhea... - Enterotoxigenic Escherichia coli in developing countries: epidemiology, microbiology, clinical features, treatment, and preventionFirdausi Qadri
International Centre for Diarrhoeal Disease Research, Bangladesh
Clin Microbiol Rev 18:465-83. 2005..Increases in antimicrobial resistance will dictate the drugs used for the treatment of traveler's diarrhea. Efforts need to be made to improve our understanding of the worldwide importance of ETEC... - Enterotoxigenic Escherichia coli isolated from surface water in urban and rural areas of BangladeshYasmin A Begum
J Clin Microbiol 43:3582-3. 2005 - Serologic correlates of protection against enterotoxigenic Escherichia coli diarrheaMalla R Rao
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, Maryland 20910-7500, USA
J Infect Dis 191:562-70. 2005.... - Breast milk reduces the risk of illness in children of mothers with cholera: observations from an epidemic of cholera in Guinea-BissauKatja Qureshi
Projecto de Saude de Bandim, Bissau, Guinea Bissau
Pediatr Infect Dis J 25:1163-6. 2006....