Jia Bin Sun

Summary

Country: Sweden

Publications

  1. doi request reprint B lymphocytes treated in vitro with antigen coupled to cholera toxin B subunit induce antigen-specific Foxp3(+) regulatory T cells and protect against experimental autoimmune encephalomyelitis
    Jia Bin Sun
    University of Gothenburg Vaccine Research Institute, Sahlgrenska Academy at the University of Gothenburg, SE 405 30, Goteborg, Sweden
    J Immunol 188:1686-97. 2012
  2. ncbi request reprint Intranasal administration of a Schistosoma mansoni glutathione S-transferase-cholera toxoid conjugate vaccine evokes antiparasitic and antipathological immunity in mice
    J B Sun
    Department of Medical Microbiology and Immunology, University of Goteborg, Sweden
    J Immunol 163:1045-52. 1999
  3. doi request reprint Mucosally induced immunological tolerance, regulatory T cells and the adjuvant effect by cholera toxin B subunit
    J B Sun
    Institute of Biomedicine, Department of Microbiology and Immunology, and University of Gothenburg Vaccine Research Institute, Sahlgrenska Academy at University of Gothenburg, Goteborg, Sweden
    Scand J Immunol 71:1-11. 2010
  4. ncbi request reprint Sublingual 'oral tolerance' induction with antigen conjugated to cholera toxin B subunit generates regulatory T cells that induce apoptosis and depletion of effector T cells
    J B Sun
    Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy at Gothenburg University, Goteborg, Sweden
    Scand J Immunol 66:278-86. 2007
  5. ncbi request reprint Oral tolerance induction with antigen conjugated to cholera toxin B subunit generates both Foxp3+CD25+ and Foxp3-CD25- CD4+ regulatory T cells
    Jia Bin Sun
    Department of Microbiology and Immunology, Institute of Biomedicine and Göteborg University Vaccine Research Institute, Sahlgrenska Academy at Goteborg University, 405 30 Goteborg, Sweden
    J Immunol 177:7634-44. 2006
  6. ncbi request reprint Vaccination with dendritic cells pulsed in vitro with tumor antigen conjugated to cholera toxin efficiently induces specific tumoricidal CD8+ cytotoxic lymphocytes dependent on cyclic AMP activation of dendritic cells
    J B Sun
    Department of Medical Microbiology and Immunology, and Göteborg University Vaccine Research Institute GUVAX, Goteborg University, S 405 30, Goteborg, Sweden
    Clin Immunol 112:35-44. 2004
  7. ncbi request reprint Nasal administration of Schistosoma mansoni egg antigen-cholera B subunit conjugate suppresses hepatic granuloma formation and reduces mortality in S. mansoni-infected mice
    J B Sun
    Department of Medical Microbiology and Immunology, University of Goteborg, Guldhedsgatan 10 A, SE 413 46 Goteborg, Sweden
    Scand J Immunol 54:440-7. 2001
  8. ncbi request reprint Enhanced immunological tolerance against allograft rejection by oral administration of allogeneic antigen linked to cholera toxin B subunit
    J B Sun
    Department of Medical Microbiology and Immunology, Goteborg University, Goteborg, S 413 46, Sweden
    Clin Immunol 97:130-9. 2000
  9. ncbi request reprint B lymphocytes promote expansion of regulatory T cells in oral tolerance: powerful induction by antigen coupled to cholera toxin B subunit
    Jia Bin Sun
    Department of Microbiology and Immunology, University of Gothenburg Vaccine Research Institute, Institute of Biomedicine Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    J Immunol 181:8278-87. 2008
  10. ncbi request reprint A mucosally administered recombinant fusion protein vaccine against schistosomiasis protecting against immunopathology and infection
    Michael Lebens
    Department of Medical Microbiology and Immunology, Göteborg University and the Göteborg University Research Institute, Guldhedsgatan 10A, SE 413 46, Goteborg, Sweden
    Vaccine 21:514-20. 2003

Collaborators

Detail Information

Publications18

  1. doi request reprint B lymphocytes treated in vitro with antigen coupled to cholera toxin B subunit induce antigen-specific Foxp3(+) regulatory T cells and protect against experimental autoimmune encephalomyelitis
    Jia Bin Sun
    University of Gothenburg Vaccine Research Institute, Sahlgrenska Academy at the University of Gothenburg, SE 405 30, Goteborg, Sweden
    J Immunol 188:1686-97. 2012
    ..Our results suggest that B cells pulsed in vitro with relevant Ag/CTB conjugates may be used in cell therapy to induce Ag-specific suppression of autoimmune disease...
  2. ncbi request reprint Intranasal administration of a Schistosoma mansoni glutathione S-transferase-cholera toxoid conjugate vaccine evokes antiparasitic and antipathological immunity in mice
    J B Sun
    Department of Medical Microbiology and Immunology, University of Goteborg, Sweden
    J Immunol 163:1045-52. 1999
    ..Our results suggest that it may be possible to design a therapeutic vaccine against schistosomiasis that both limits infection and suppresses parasite-induced pathology...
  3. doi request reprint Mucosally induced immunological tolerance, regulatory T cells and the adjuvant effect by cholera toxin B subunit
    J B Sun
    Institute of Biomedicine, Department of Microbiology and Immunology, and University of Gothenburg Vaccine Research Institute, Sahlgrenska Academy at University of Gothenburg, Goteborg, Sweden
    Scand J Immunol 71:1-11. 2010
    ....
  4. ncbi request reprint Sublingual 'oral tolerance' induction with antigen conjugated to cholera toxin B subunit generates regulatory T cells that induce apoptosis and depletion of effector T cells
    J B Sun
    Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy at Gothenburg University, Goteborg, Sweden
    Scand J Immunol 66:278-86. 2007
    ....
  5. ncbi request reprint Oral tolerance induction with antigen conjugated to cholera toxin B subunit generates both Foxp3+CD25+ and Foxp3-CD25- CD4+ regulatory T cells
    Jia Bin Sun
    Department of Microbiology and Immunology, Institute of Biomedicine and Göteborg University Vaccine Research Institute, Sahlgrenska Academy at Goteborg University, 405 30 Goteborg, Sweden
    J Immunol 177:7634-44. 2006
    ....
  6. ncbi request reprint Vaccination with dendritic cells pulsed in vitro with tumor antigen conjugated to cholera toxin efficiently induces specific tumoricidal CD8+ cytotoxic lymphocytes dependent on cyclic AMP activation of dendritic cells
    J B Sun
    Department of Medical Microbiology and Immunology, and Göteborg University Vaccine Research Institute GUVAX, Goteborg University, S 405 30, Goteborg, Sweden
    Clin Immunol 112:35-44. 2004
    ....
  7. ncbi request reprint Nasal administration of Schistosoma mansoni egg antigen-cholera B subunit conjugate suppresses hepatic granuloma formation and reduces mortality in S. mansoni-infected mice
    J B Sun
    Department of Medical Microbiology and Immunology, University of Goteborg, Guldhedsgatan 10 A, SE 413 46 Goteborg, Sweden
    Scand J Immunol 54:440-7. 2001
    ..These results indicate that mucosal administration of SEA or purified Sm-p40 antigen in conjunction with CTB is highly effective in curtailing immunopathologic manifestations of schistosomiasis in vivo in infected hosts...
  8. ncbi request reprint Enhanced immunological tolerance against allograft rejection by oral administration of allogeneic antigen linked to cholera toxin B subunit
    J B Sun
    Department of Medical Microbiology and Immunology, Goteborg University, Goteborg, S 413 46, Sweden
    Clin Immunol 97:130-9. 2000
    ..The results indicate that the protection against allograft rejection by oral treatment with CTB-ATC is mediated by T cells and associated with a strong induction of IL-4 production at mucosal sites and TGF-beta(1) at the effector sites...
  9. ncbi request reprint B lymphocytes promote expansion of regulatory T cells in oral tolerance: powerful induction by antigen coupled to cholera toxin B subunit
    Jia Bin Sun
    Department of Microbiology and Immunology, University of Gothenburg Vaccine Research Institute, Institute of Biomedicine Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    J Immunol 181:8278-87. 2008
    ....
  10. ncbi request reprint A mucosally administered recombinant fusion protein vaccine against schistosomiasis protecting against immunopathology and infection
    Michael Lebens
    Department of Medical Microbiology and Immunology, Göteborg University and the Göteborg University Research Institute, Guldhedsgatan 10A, SE 413 46, Goteborg, Sweden
    Vaccine 21:514-20. 2003
    ..The results suggest that this type of hybrid protein could be used as a combined anti-immunopathology and anti-infection vaccine against schistosomiasis...
  11. ncbi request reprint Coupling of antigen to cholera toxin for dendritic cell vaccination promotes the induction of MHC class I-restricted cytotoxic T cells and the rejection of a cognate antigen-expressing model tumor
    Kristina Eriksson
    Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, Goteborg University, Gothenberg, Sweden
    Eur J Immunol 34:1272-81. 2004
    ..These results have interesting implications for DC vaccination aimed at inducing CTL immune responses...
  12. ncbi request reprint Current status and future prospects for a vaccine against schistosomiasis
    Michael Lebens
    Goteborg University, Department of Medical Microbiology and Immunology, PO Box 435, SE 405 30 Gothenburg, Sweden
    Expert Rev Vaccines 3:315-28. 2004
    ..This review summarizes the life-cycle of the parasite, current knowledge of pathogenesis and acquired immunity based on animal studies and observations in humans and the status of efforts in the vaccine development field...
  13. ncbi request reprint Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA
    Jan Holmgren
    Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, Goteborg University, P O Box 435, SE 40530 Goteborg, Sweden
    Immunol Lett 97:181-8. 2005
    ..The properties and clinical potential of these different classes of adjuvants are being discussed...
  14. doi request reprint Impaired IFN-γ production after stimulation with bacterial components by natural killer cells from gastric cancer patients
    Asa Lindgren
    Institute of Biomedicine, Department of Microbiology and Immunology, and Mucosal Immunobiology and Vaccine Institute for Strategic Research, University of Gothenburg, Box 435, 405 30 Gothenburg, Sweden
    Exp Cell Res 317:849-58. 2011
    ..In addition, we propose that the observed suppression is due to tumour-derived TGF-β and that increased expression of the transcription factor GATA-3 may be responsible for the TGF-β induced suppression...
  15. pmc Uncoupling of natural IgE production and CD23 surface expression levels
    Weicheng Ren
    Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 8:e62851. 2013
    ....
  16. ncbi request reprint Protective immunity to genital herpes simplex [correction of simpex] virus type 2 infection is mediated by T-bet
    Alexandra Svensson
    Department of Rheumatology and Inflammation Research, Goteborg University, Goteborg, Sweden
    J Immunol 174:6266-73. 2005
    ..We conclude that T-bet plays a crucial role in both the innate defense and the generation of vaccine-induced immunity against genital HSV-2 infection in mice...
  17. ncbi request reprint Sublingual immunization induces broad-based systemic and mucosal immune responses in mice
    Nicolas Cuburu
    Institut National de la Sante et de la Recherche Medicale INSERM, Unité Mixte de Recherche UMR 721, Universite de Nice Sophia Antipolis, Nice, France
    Vaccine 25:8598-610. 2007
    ..These features underscore the potential of the s.l. mucosa to serve as an alternative vaccine delivery route...
  18. ncbi request reprint Prevention of mucosally induced uveitis with a HSP60-derived peptide linked to cholera toxin B subunit
    Paula A Phipps
    Peter Gorer Department of Immunobiology, Guy s, King s and St Thomas School of Medicine and Dentistry, Guy s Hospital, London, GB
    Eur J Immunol 33:224-32. 2003
    ..We suggest that mucosally induced uveitis can be prevented by oral administration of the peptide-rCTB conjugate...