D R Nässel

Summary

Affiliation: Stockholm University
Country: Sweden

Publications

  1. ncbi request reprint Tachykinin-related peptides in invertebrates: a review
    D R Nässel
    Department of Zoology, Stockholm University, Sweden
    Peptides 20:141-58. 1999
  2. doi request reprint Neuropeptide signaling near and far: how localized and timed is the action of neuropeptides in brain circuits?
    Dick R Nassel
    Department of Zoology, Stockholm University, 10691 Stockholm, Sweden
    Invert Neurosci 9:57-75. 2009
  3. pmc Insulin/IGF-Regulated Size Scaling of Neuroendocrine Cells Expressing the bHLH Transcription Factor Dimmed in Drosophila
    Jiangnan Luo
    Department of Zoology, Stockholm University, Stockholm, Sweden
    PLoS Genet 9:e1004052. 2013
  4. pmc Metabolic stress responses in Drosophila are modulated by brain neurosecretory cells that produce multiple neuropeptides
    Lily Kahsai
    Department of Zoology, Stockholm University, Stockholm, Sweden
    PLoS ONE 5:e11480. 2010
  5. pmc Glutamate, GABA and acetylcholine signaling components in the lamina of the Drosophila visual system
    Agata Kolodziejczyk
    Department of Zoology, Stockholm University, Stockholm, Sweden
    PLoS ONE 3:e2110. 2008
  6. pmc Insulin production and signaling in renal tubules of Drosophila is under control of tachykinin-related peptide and regulates stress resistance
    Jeannette A E Söderberg
    Department of Zoology, Stockholm University, Stockholm, Sweden
    PLoS ONE 6:e19866. 2011
  7. pmc Insulin-Producing Cells in the Drosophila Brain also Express Satiety-Inducing Cholecystokinin-Like Peptide, Drosulfakinin
    Jeannette A E Söderberg
    Department of Zoology, Stockholm University Stockholm, Sweden
    Front Endocrinol (Lausanne) 3:109. 2012
  8. pmc Insulin signaling, lifespan and stress resistance are modulated by metabotropic GABA receptors on insulin producing cells in the brain of Drosophila
    Lina E Enell
    Department of Zoology, Stockholm University, Stockholm, Sweden
    PLoS ONE 5:e15780. 2010
  9. ncbi request reprint Species-specific action and distribution of tachykinin-related peptides in the foregut of the cockroaches Leucophaea maderae and Periplaneta americana
    D R Nässel
    Department of Zoology, Stockholm University, Stockholm, Sweden
    J Exp Biol 201:1615-26. 1998
  10. doi request reprint Drosophila neuropeptides in regulation of physiology and behavior
    Dick R Nassel
    Department of Zoology, Stockholm University, S 10691 Stockholm, Sweden
    Prog Neurobiol 92:42-104. 2010

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Tachykinin-related peptides in invertebrates: a review
    D R Nässel
    Department of Zoology, Stockholm University, Sweden
    Peptides 20:141-58. 1999
    ..Invertebrate TRPs may also be involved in developmental processes...
  2. doi request reprint Neuropeptide signaling near and far: how localized and timed is the action of neuropeptides in brain circuits?
    Dick R Nassel
    Department of Zoology, Stockholm University, 10691 Stockholm, Sweden
    Invert Neurosci 9:57-75. 2009
    ..Other factors such as expression of different channel types, receptor inactivation mechanisms and second messenger systems probably also contribute to the diversity in temporal properties of peptide signaling...
  3. pmc Insulin/IGF-Regulated Size Scaling of Neuroendocrine Cells Expressing the bHLH Transcription Factor Dimmed in Drosophila
    Jiangnan Luo
    Department of Zoology, Stockholm University, Stockholm, Sweden
    PLoS Genet 9:e1004052. 2013
    ..We suggest that the dInR-mediated scaling of neuroendocrine cells is part of a plasticity that adapts the secretory capacity to changing physiological conditions and nutrient-dependent organismal growth. ..
  4. pmc Metabolic stress responses in Drosophila are modulated by brain neurosecretory cells that produce multiple neuropeptides
    Lily Kahsai
    Department of Zoology, Stockholm University, Stockholm, Sweden
    PLoS ONE 5:e11480. 2010
    ..Our data suggest that homeostasis during metabolic stress requires intact peptide signaling by ipc-1 and 2a neurosecretory cells...
  5. pmc Glutamate, GABA and acetylcholine signaling components in the lamina of the Drosophila visual system
    Agata Kolodziejczyk
    Department of Zoology, Stockholm University, Stockholm, Sweden
    PLoS ONE 3:e2110. 2008
    ..In summary, this paper describes novel features of two distinct types of tangential neurons in the Drosophila lamina and assigns putative neurotransmitters and some receptors to a few identified neuron types...
  6. pmc Insulin production and signaling in renal tubules of Drosophila is under control of tachykinin-related peptide and regulates stress resistance
    Jeannette A E Söderberg
    Department of Zoology, Stockholm University, Stockholm, Sweden
    PLoS ONE 6:e19866. 2011
    ..Our findings are the first to demonstrate DILP signaling originating in the renal tubules and that this signaling is under control of stress-induced release of peptide hormone...
  7. pmc Insulin-Producing Cells in the Drosophila Brain also Express Satiety-Inducing Cholecystokinin-Like Peptide, Drosulfakinin
    Jeannette A E Söderberg
    Department of Zoology, Stockholm University Stockholm, Sweden
    Front Endocrinol (Lausanne) 3:109. 2012
    ..In summary, DSK and DILPs released from the IPCs regulate feeding, food choice and metabolic homeostasis in Drosophila in a coordinated fashion...
  8. pmc Insulin signaling, lifespan and stress resistance are modulated by metabotropic GABA receptors on insulin producing cells in the brain of Drosophila
    Lina E Enell
    Department of Zoology, Stockholm University, Stockholm, Sweden
    PLoS ONE 5:e15780. 2010
    ..This is the first demonstration of a neurotransmitter that inhibits insulin signaling in its regulation of metabolism, stress and life span in an invertebrate brain...
  9. ncbi request reprint Species-specific action and distribution of tachykinin-related peptides in the foregut of the cockroaches Leucophaea maderae and Periplaneta americana
    D R Nässel
    Department of Zoology, Stockholm University, Stockholm, Sweden
    J Exp Biol 201:1615-26. 1998
    ..americana and L. maderae, TRPs may be involved in the control of foregut movements in both species, but in P. americana the control may be more complex with the additional peripherally projecting LomTK-LI neurons...
  10. doi request reprint Drosophila neuropeptides in regulation of physiology and behavior
    Dick R Nassel
    Department of Zoology, Stockholm University, S 10691 Stockholm, Sweden
    Prog Neurobiol 92:42-104. 2010
    ..Functions of some peptides are better understood than others, and much work remains to reveal the spectrum of roles neuropeptides and peptide hormones play in the daily life of a fly...
  11. pmc A large population of diverse neurons in the Drosophila central nervous system expresses short neuropeptide F, suggesting multiple distributed peptide functions
    Dick R Nassel
    Department of Zoology, Stockholm University, S 10691 Stockholm, Sweden
    BMC Neurosci 9:90. 2008
    ..To unravel possible functional diversity we have mapped the distribution of transcript of the snpf gene and its peptide products in the central nervous system (CNS) of Drosophila in relation to other neuronal markers...
  12. ncbi request reprint Neuropeptides in interneurons of the insect brain
    Dick R Nassel
    Department of Zoology, Stockholm University, Sweden
    Cell Tissue Res 326:1-24. 2006
    ..Studies so far indicate that neuropeptides can play a multitude of functional roles in the brain and that even single neuropeptides are likely to be multifunctional...
  13. ncbi request reprint Neuropeptides in the nervous system of Drosophila and other insects: multiple roles as neuromodulators and neurohormones
    Dick R Nassel
    Department of Zoology, Stockholm University, SE 106 91, Stockholm, Sweden
    Prog Neurobiol 68:1-84. 2002
    ..Drosophila, in spite of its small size, is now emerging as a very favorable organism for the studies of neuropeptide function due to the arsenal of molecular genetics methods available...
  14. ncbi request reprint Neuronal co-localization of different isoforms of tachykinin-related peptides (LemTRPs) in the cockroach brain
    Dick R Nassel
    Department of Zoology, Stockholm University, 10691 Stockholm, Sweden
    Cell Tissue Res 308:225-39. 2002
    ..Thus, LemTRP-2 may be released with the other shorter LemTRPs. This is the first investigation of LemTRP distribution in the cockroach central nervous system utilizing antisera to native peptides...
  15. doi request reprint A comparative review of short and long neuropeptide F signaling in invertebrates: Any similarities to vertebrate neuropeptide Y signaling?
    Dick R Nassel
    Department of Zoology, Stockholm University, S 10691 Stockholm, Sweden
    Peptides 32:1335-55. 2011
    ..Available data indicate that NPF and sNPF signaling systems are distinct and not likely to play redundant roles...
  16. ncbi request reprint Functional roles of neuropeptides in the insect central nervous system
    D R Nässel
    Department of Zoology, Stockholm University, 10691 Stockholm, Sweden
    Naturwissenschaften 87:439-49. 2000
    ..Considering the large number of neuropeptides available in each insect species and their diverse distribution patterns, it is to be expected that different neuropeptides play roles in most aspects of insect physiology and behavior...
  17. ncbi request reprint Histamine in the brain of insects: a review
    D R Nässel
    Department of Zoology, Stockholm University, Sweden
    Microsc Res Tech 44:121-36. 1999
    ..Novel data are presented for Drosophila and the cockroach Leucophaea maderae and a comparison is made with published data on other insects...
  18. ncbi request reprint Proline-specific dipeptidyl peptidase activity in the cockroach brain and intestine: partial characterization, distribution, and inactivation of tachykinin-related peptides
    D R Nässel
    Department of Zoology, Stockholm University, Sweden
    J Comp Neurol 418:81-92. 2000
    ..Also, the inner lining of the midgut (the peritrophic membrane) and the malpighian tubules were strongly labeled by reaction product. In both the brain and intestine, the enzyme-histochemical reaction was inhibited by diprotin A...
  19. ncbi request reprint Baratin, a nonamidated neurostimulating neuropeptide, isolated from cockroach brain: distribution and actions in the cockroach and locust nervous systems
    D R Nässel
    Department of Zoology, Stockholm University, S 10691 Stockholm, Sweden
    J Comp Neurol 422:267-86. 2000
    ..Thus baratin appears to have a role in modulation of motor patterns in abdominal ganglia. The immunocytochemical findings suggest further modulatory actions of baratin in different circuits of the brain and ventral nerve cord...
  20. ncbi request reprint Peptidergic neurohormonal control systems in invertebrates
    D R Nässel
    Department of Zoology, Stockholm University, S 106 91 Stockholm, Sweden
    Curr Opin Neurobiol 6:842-50. 1996
    ..One prominent role of neuropeptides is to modulate the activity of rhythm-generating circuits, as exemplified by recent research on mollusc neural networks, the crab stomatogastric ganglion, and fly circadian pacemakers...
  21. ncbi request reprint Neuropeptides, amines and amino acids in an elementary insect ganglion: functional and chemical anatomy of the unfused abdominal ganglion
    D R Nässel
    Department of Zoology, Stockholm University, Sweden
    Prog Neurobiol 48:325-420. 1996
    ..Some emphasis is made of the presence of neuroactive compounds in neurosecretory cells and other identifiable neurons for which physiological analysis is feasible...
  22. ncbi request reprint Several isoforms of locustatachykinins may be involved in cyclic AMP-mediated release of adipokinetic hormones from the locust Corpora cardiaca
    D R Nässel
    Department of Zoology, Stockholm University, Stockholm, Sweden
    Gen Comp Endocrinol 113:401-12. 1999
    ..These results support the proposal that LomTKs are involved in controlling the release of the adipokinetic hormones and suggest that all LomTK isoforms may participate in this cyclic AMP-mediated event...
  23. ncbi request reprint Locustatachykinin immunoreactivity in the blowfly central nervous system and intestine
    C T Lundquist
    Department of Zoology, Stockholm University, Sweden
    J Comp Neurol 341:225-40. 1994
    ..Additionally a regulatory function in the intestine is indicated by the presence of immunoreactivity in endocrine cells of the midgut...
  24. ncbi request reprint Tachykinin- and leucokinin-related peptides in the nervous system of the blowfly: immunocytochemical and chromatographical diversity
    C T Lundquist
    Department of Zoology, Stockholm University, Sweden
    Peptides 14:651-63. 1993
    ..The kassinin immunoreactivity was seen in interneurons, but could not be conclusively localized in neurosecretory cells, possibly indicating a role only within the nervous system...
  25. ncbi request reprint Pigment-dispersing hormone-like peptide in the nervous system of the flies Phormia and Drosophila: immunocytochemistry and partial characterization
    D R Nässel
    Department of Zoology, Stockholm University, Sweden
    J Comp Neurol 331:183-98. 1993
    ....
  26. pmc CalpA, a Drosophila calpain homolog specifically expressed in a small set of nerve, midgut, and blood cells
    U Theopold
    Department of Molecular Biology, Stockholm University, Sweden
    Mol Cell Biol 15:824-34. 1995
    ..This insert contains a hydrophobic region that may be involved in membrane attachment of the enzyme. Differential splicing also gives rise to a minor transcript that lacks the calmodulin-like domain...
  27. ncbi request reprint Pigment-dispersing factor in the locust abdominal ganglia may have roles as circulating neurohormone and central neuromodulator
    M G Persson
    Department of Zoology, Stockholm University, SE-10691 Stockholm, Sweden
    J Neurobiol 48:19-41. 2001
    ..Thus, PDF seems to have a modulatory role in central neuronal circuits of the terminal abdominal ganglion that control muscles of genital organs...
  28. doi request reprint Distribution of metabotropic receptors of serotonin, dopamine, GABA, glutamate, and short neuropeptide F in the central complex of Drosophila
    L Kahsai
    Department of Zoology, Stockholm University, S 10691 Stockholm, Sweden
    Neuroscience 208:11-26. 2012
    ..The information provided here, on receptor distribution, will be very useful for future analysis of functional circuits in the central complex, based on targeted interference with receptor expression...
  29. ncbi request reprint Intestinal peptides as circulating hormones: release of tachykinin-related peptide from the locust and cockroach midgut
    A M Winther
    Department of Zoology, Stockholm University, SE-10691 Stockholm, Sweden
    J Exp Biol 204:1269-80. 2001
    ....
  30. ncbi request reprint Substance P-, FMRFamide-, and gastrin/cholecystokinin-like immunoreactive neurons in the thoraco-abdominal ganglia of the flies Drosophila and Calliphora
    T Lundquist
    Department of Zoology, University of Stockholm, Sweden
    J Comp Neurol 294:161-78. 1990
    ..From the present study it appears as if neuropeptides related to substance P, FMRFamide and CCK have roles as neurotransmitters/neuromodulators and circulating neurohormones in Drosophila and Calliphora...
  31. ncbi request reprint Cardioacceleratory action of tachykinin-related neuropeptides and proctolin in two coleopteran insect species
    J Sliwowska
    Department of Zoology, Stockholm University, S-10691 Stockholm, Sweden
    Peptides 22:209-17. 2001
    ..The differences in the responses to proctolin and TRPs suggest that the peptides regulate heart activity by different mechanisms...
  32. ncbi request reprint A putative tachykinin receptor in the cockroach brain: molecular cloning and analysis of expression by means of antisera to portions of the receptor protein
    H A Johard
    Department of Zoology, Stockholm University, SE-10691, Stockholm, Sweden
    Brain Res 919:94-105. 2001
    ..Some brain areas, however, only display TRP immunoreactive processes and no LTKR, suggesting the presence of at least one more TRP receptor type...