Affiliation: Stockholm University
- A brief introduction to cell-penetrating peptidesPontus Lundberg
Department of Neurochemistry and Neurotoxicology, Svante Arrhenius Väg 21A, Stockholm University, S 10691 Stockholm, Sweden
J Mol Recognit 16:227-33. 2003....
- Delivery of short interfering RNA using endosomolytic cell-penetrating peptidesPontus Lundberg
Department of Neurochemistry, Stockholm University, Svante Arrhenius Väg 21A, S 10691 Stockholm, Sweden
FASEB J 21:2664-71. 2007..We believe that developing CPPs with increased endosomolytical properties is a necessary step toward achieving biological effects at low concentrations for future in vivo applications...
- Relevance of the N-terminal NLS-like sequence of the prion protein for membrane perturbation effectsKamila Oglecka
Department of Biochemistry and Biophysics, The Arrhenius Laboratories, Stockholm University, S 106 91 Stockholm, Sweden
Biochim Biophys Acta 1778:206-13. 2008..We conclude that the KKRPKP-sequence is not sufficient to cause membrane perturbation or translocation but needs a hydrophobic counterpart...
- Differential membrane perturbation caused by the cell penetrating peptide Tp10 depending on attached cargoElsa Bárány-Wallje
Department of Biochemistry and Biophysics, The Arrhenius Laboratories, Stockholm University, S 10691 Stockholm, Sweden
FEBS Lett 581:2389-93. 2007..The results suggest that direct membrane effects may cause membrane translocation of Tp10 alone and of smaller complexes, whereas these effects do not contribute for larger cargoes...
- Studying the uptake of cell-penetrating peptidesTina Holm
Department of Neurochemistry, Stockholm University, S Arrheniusv 21A, SE 106 91, Stockholm, Sweden
Nat Protoc 1:1001-5. 2006..All three protocols are based on the use of fluorescently labeled peptides and can be performed on the same workday...
- Antiprion properties of prion protein-derived cell-penetrating peptidesKajsa Löfgren
Department of Biochemistry and Biophysics, The Arrhenius Laboratories, Stockholm University, SE 106 91 Stockholm, Sweden
FASEB J 22:2177-84. 2008..The results suggest a mechanism by which the signal sequence guides the prion protein-derived CPP into a cellular compartment, where the basic segment binds specifically to PrP(Sc) and disables formation of prions...
- Induction of splice correction by cell-penetrating peptide nucleic acidsSamir El-Andaloussi
Department of Neurochemistry, Stockholm University, S Arrheniusv 21A, SE 10691 Stockholm, Sweden
J Gene Med 8:1262-73. 2006..Here we present splice-correcting peptide nucleic acids (PNAs), tethered to a variety of cell-penetrating peptides (CPPs), evaluating their mechanism of uptake and ability to correct aberrant splicing...
- N-terminal peptides from unprocessed prion proteins enter cells by macropinocytosisMazin Magzoub
Department of Biochemistry and Biophysics, Stockholm University, Sweden
Biochem Biophys Res Commun 348:379-85. 2006....
- Two novel targeting peptide degrading proteases, PrePs, in mitochondria and chloroplasts, so similar and still differentAnnelie Stahl
Department of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural Sciences, Stockholm University, SE 106 91 Stockholm, Sweden
J Mol Biol 349:847-60. 2005..In conclusion, despite the high sequence identity between AtPrePI and AtPrePII and similarities in cleavage specificities, cleavage site recognition differs for both proteases and is context and structure dependent...