Sara Light

Summary

Affiliation: Stockholm University
Country: Sweden

Publications

  1. pmc Network analysis of metabolic enzyme evolution in Escherichia coli
    Sara Light
    Stockholm Bioinformatics Center, Department of Biochemistry and Biophysics, Stockholm Center for Physics, Astronomy and Biotechnology, Stockholm University, Stockholm SE 10691, Sweden
    BMC Bioinformatics 5:15. 2004
  2. pmc Preferential attachment in the evolution of metabolic networks
    Sara Light
    Stockholm Bioinformatics Center, Department of Biochemistry and Biophyhsics, AlbaNova University Center, Stockholm University, Stockholm SE 10691, Sweden
    BMC Genomics 6:159. 2005
  3. pmc What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae?
    Diana Ekman
    Stockholm Bioinformatics Center, Stockholm University, Stockholm, Sweden
    Genome Biol 7:R45. 2006
  4. doi request reprint Quantitative assessment of the structural bias in protein-protein interaction assays
    Asa K Björklund
    Department of Biochemistry and Biophysics, Center for Biological Membrane Research Stockholm Bioinformatics Center, Stockholm University, Stockholm, Sweden
    Proteomics 8:4657-67. 2008
  5. doi request reprint Improved production of membrane proteins in Escherichia coli by selective codon substitutions
    Morten H H Nørholm
    Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, SE 106 91 Stockholm, Sweden Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK 2970 Hørsholm, Denmark Electronic address
    FEBS Lett 587:2352-8. 2013
  6. doi request reprint Nebulin: a study of protein repeat evolution
    Asa K Björklund
    Center for Biological Membrane Research, Stockholm Bioinformatics Center, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden
    J Mol Biol 402:38-51. 2010
  7. doi request reprint Long indels are disordered: a study of disorder and indels in homologous eukaryotic proteins
    Sara Light
    Science for Life Laboratory, Stockholm University, Solna, Sweden
    Biochim Biophys Acta 1834:890-7. 2013
  8. pmc The evolution of filamin-a protein domain repeat perspective
    Sara Light
    Center for Biomembrane Research, Department of Biochemistry and Biophysics, Science for Life Laboratory, Bioinformatics Infrastructure for Life Sciences, Stockholm University, SE 17121 Solna, Sweden
    J Struct Biol 179:289-98. 2012
  9. ncbi request reprint Domain rearrangements in protein evolution
    Asa K Björklund
    Stockholm Bioinformatics Center, Stockholm University, SE 10691 Stockholm, Sweden
    J Mol Biol 353:911-23. 2005
  10. doi request reprint The impact of splicing on protein domain architecture
    Sara Light
    Science for Life Laboratory, Stockholm University, Box 1031 SE 171 21 Solna, Sweden
    Curr Opin Struct Biol 23:451-8. 2013

Collaborators

Detail Information

Publications12

  1. pmc Network analysis of metabolic enzyme evolution in Escherichia coli
    Sara Light
    Stockholm Bioinformatics Center, Department of Biochemistry and Biophysics, Stockholm Center for Physics, Astronomy and Biotechnology, Stockholm University, Stockholm SE 10691, Sweden
    BMC Bioinformatics 5:15. 2004
    ..We here investigate the evolution of the metabolism in E. coli viewed as a single network using EcoCyc...
  2. pmc Preferential attachment in the evolution of metabolic networks
    Sara Light
    Stockholm Bioinformatics Center, Department of Biochemistry and Biophyhsics, AlbaNova University Center, Stockholm University, Stockholm SE 10691, Sweden
    BMC Genomics 6:159. 2005
    ..In networks which have evolved through preferential attachment older nodes should have a higher average connectivity than younger nodes. Here we have investigated preferential attachment in the context of metabolic networks...
  3. pmc What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae?
    Diana Ekman
    Stockholm Bioinformatics Center, Stockholm University, Stockholm, Sweden
    Genome Biol 7:R45. 2006
    ..Therefore, we have investigated what differentiates hubs from non-hubs and static hubs (party hubs) from dynamic hubs (date hubs) in the protein-protein interaction network of Saccharomyces cerevisiae...
  4. doi request reprint Quantitative assessment of the structural bias in protein-protein interaction assays
    Asa K Björklund
    Department of Biochemistry and Biophysics, Center for Biological Membrane Research Stockholm Bioinformatics Center, Stockholm University, Stockholm, Sweden
    Proteomics 8:4657-67. 2008
    ..Most importantly, we show that there are method-specific biases in PPI experiments. Thus, care should be taken before drawing strong conclusions based on a single dataset...
  5. doi request reprint Improved production of membrane proteins in Escherichia coli by selective codon substitutions
    Morten H H Nørholm
    Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, SE 106 91 Stockholm, Sweden Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK 2970 Hørsholm, Denmark Electronic address
    FEBS Lett 587:2352-8. 2013
    ..We conclude that coding sequences can be re-wired for high-level protein expression by selective engineering of the 5' coding sequence with synonymous codons, thus circumventing the need to consider whole sequence optimization. ..
  6. doi request reprint Nebulin: a study of protein repeat evolution
    Asa K Björklund
    Center for Biological Membrane Research, Stockholm Bioinformatics Center, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden
    J Mol Biol 402:38-51. 2010
    ..In fact, segmental duplications are found three to six times more often in long repeated genes than expected by chance...
  7. doi request reprint Long indels are disordered: a study of disorder and indels in homologous eukaryotic proteins
    Sara Light
    Science for Life Laboratory, Stockholm University, Solna, Sweden
    Biochim Biophys Acta 1834:890-7. 2013
    ..This article is part of a Special Issue entitled: The emerging dynamic view of proteins: Protein plasticity in allostery, evolution and self-assembly...
  8. pmc The evolution of filamin-a protein domain repeat perspective
    Sara Light
    Center for Biomembrane Research, Department of Biochemistry and Biophysics, Science for Life Laboratory, Bioinformatics Infrastructure for Life Sciences, Stockholm University, SE 17121 Solna, Sweden
    J Struct Biol 179:289-98. 2012
    ..Given that invertebrate integrin shows more similarity to the weaker filamin binder, integrin β3, it is possible that the distance between integrin-binding domains is not as crucial for invertebrate filamins as for vertebrates...
  9. ncbi request reprint Domain rearrangements in protein evolution
    Asa K Björklund
    Stockholm Bioinformatics Center, Stockholm University, SE 10691 Stockholm, Sweden
    J Mol Biol 353:911-23. 2005
    ..Finally, the evolution of multi-domain proteins is exemplified by a closer study of the evolution of two protein families, non-receptor tyrosine kinases and RhoGEFs...
  10. doi request reprint The impact of splicing on protein domain architecture
    Sara Light
    Science for Life Laboratory, Stockholm University, Box 1031 SE 171 21 Solna, Sweden
    Curr Opin Struct Biol 23:451-8. 2013
    ..Here, we review the state of the art methods for identification of functional isoforms and present a summary of what is known, thus far, about alternative splicing with regard to protein domain architectures...
  11. pmc Manipulating the genetic code for membrane protein production: what have we learnt so far?
    Morten H H Nørholm
    Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, SE 106 91, Sweden
    Biochim Biophys Acta 1818:1091-6. 2012
    ..This article is part of a Special Issue entitled: Protein Folding in Membranes...
  12. ncbi request reprint Evolution after gene duplication: models, mechanisms, sequences, systems, and organisms
    Christian Roth
    Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
    J Exp Zool B Mol Dev Evol 308:58-73. 2007
    ..single gene duplication. Lastly, the role that these processes may have played in driving speciation is examined...