A Forsby

Summary

Affiliation: Stockholm University
Country: Sweden

Publications

  1. doi request reprint Using novel in vitro NociOcular assay based on TRPV1 channel activation for prediction of eye sting potential of baby shampoos
    Anna Forsby
    Department of Neurochemistry, The Arrhenius Laboratories for Natural Science, Stockholm University, SE 10691 Stockholm, Sweden
    Toxicol Sci 129:325-31. 2012
  2. doi request reprint Neuronal in vitro models for the estimation of acute systemic toxicity
    A Forsby
    Department of Neurochemistry, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden
    Toxicol In Vitro 23:1564-9. 2009
  3. ncbi request reprint Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity
    Anna Forsby
    Department of Neurochemistry, Svante Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden
    Hum Exp Toxicol 26:333-8. 2007
  4. ncbi request reprint Polygodial induces inositol phosphate turnover in human neuroblastoma SH-SY5Y cells
    A Forsby
    Department of Neurochemistry and Neurotoxicology, Stockholm University, Sweden
    Neurosci Lett 217:50-4. 1996
  5. ncbi request reprint Gliotoxin induces caspase-dependent neurite degeneration and calpain-mediated general cytotoxicity in differentiated human neuroblastoma SH-SY5Y cells
    V Axelsson
    Department of Neurochemistry, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Sweden
    Biochem Biophys Res Commun 345:1068-74. 2006
  6. ncbi request reprint Acrylamide-induced effects on general and neurospecific cellular functions during exposure and recovery
    M Nordin-Andersson
    Stockholm University, Department of Neurochemistry and Neurotoxicology, Stockholm, Sweden
    Cell Biol Toxicol 19:43-51. 2003
  7. doi request reprint TRPV1 expression and activity during retinoic acid-induced neuronal differentiation
    Johanna El Andaloussi-Lilja
    Department of Neurochemistry, Stockholm University, Svante Arrhenius väg 21 A, SE 106 91 Stockholm, Sweden
    Neurochem Int 55:768-74. 2009
  8. doi request reprint Anionic linear aliphatic surfactants activate TRPV1: a possible endpoint for estimation of detergent induced eye nociception?
    H Lindegren
    Department of Neurochemistry, Stockholm University, Stockholm, Sweden
    Toxicol In Vitro 23:1472-6. 2009
  9. ncbi request reprint Insulin-like growth factor type 1 upregulates uncoupling protein 3
    H Gustafsson
    Department of Neurochemistry and Neurotoxicology, Stockholm University, Stockholm, SE-106 91, Sweden
    Biochem Biophys Res Commun 287:1105-11. 2001
  10. ncbi request reprint Development of a sensory neuronal cell model for the estimation of mild eye irritation
    Johanna Lilja
    Department of Neurochemistry and Neurotoxicology, University of Stockholm, Sweden
    Altern Lab Anim 32:339-43. 2004

Collaborators

Detail Information

Publications22

  1. doi request reprint Using novel in vitro NociOcular assay based on TRPV1 channel activation for prediction of eye sting potential of baby shampoos
    Anna Forsby
    Department of Neurochemistry, The Arrhenius Laboratories for Natural Science, Stockholm University, SE 10691 Stockholm, Sweden
    Toxicol Sci 129:325-31. 2012
    ..Our data support that the TRPV1 channel is a principal mediator of eye-stinging sensation induced by baby bath and shampoo formulations and that the NociOcular test may be a valuable in vitro tool to predict human eye-stinging sensation...
  2. doi request reprint Neuronal in vitro models for the estimation of acute systemic toxicity
    A Forsby
    Department of Neurochemistry, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden
    Toxicol In Vitro 23:1564-9. 2009
    ....
  3. ncbi request reprint Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity
    Anna Forsby
    Department of Neurochemistry, Svante Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden
    Hum Exp Toxicol 26:333-8. 2007
    ..Our results indicate that it is possible to estimate LOEDs by integrating in vitro toxicity data as surrogates for lowest observed target tissue levels with PBBK models, provided that some knowledge about toxic mechanisms is known...
  4. ncbi request reprint Polygodial induces inositol phosphate turnover in human neuroblastoma SH-SY5Y cells
    A Forsby
    Department of Neurochemistry and Neurotoxicology, Stockholm University, Sweden
    Neurosci Lett 217:50-4. 1996
    ....
  5. ncbi request reprint Gliotoxin induces caspase-dependent neurite degeneration and calpain-mediated general cytotoxicity in differentiated human neuroblastoma SH-SY5Y cells
    V Axelsson
    Department of Neurochemistry, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Sweden
    Biochem Biophys Res Commun 345:1068-74. 2006
    ..These results show that calpains and caspases have a role in the toxicity of gliotoxin in differentiated SH-SY5Y cells and that the process may be Ca(2+)-mediated...
  6. ncbi request reprint Acrylamide-induced effects on general and neurospecific cellular functions during exposure and recovery
    M Nordin-Andersson
    Stockholm University, Department of Neurochemistry and Neurotoxicology, Stockholm, Sweden
    Cell Biol Toxicol 19:43-51. 2003
    ....
  7. doi request reprint TRPV1 expression and activity during retinoic acid-induced neuronal differentiation
    Johanna El Andaloussi-Lilja
    Department of Neurochemistry, Stockholm University, Svante Arrhenius väg 21 A, SE 106 91 Stockholm, Sweden
    Neurochem Int 55:768-74. 2009
    ..The results show that TRPV1 protein expression increases during RA-induced differentiation in vitro, which generates an altered intracellular Ca(2+) homeostasis...
  8. doi request reprint Anionic linear aliphatic surfactants activate TRPV1: a possible endpoint for estimation of detergent induced eye nociception?
    H Lindegren
    Department of Neurochemistry, Stockholm University, Stockholm, Sweden
    Toxicol In Vitro 23:1472-6. 2009
    ..These results reveal a new mechanistic pathway for surfactant-induced nociception...
  9. ncbi request reprint Insulin-like growth factor type 1 upregulates uncoupling protein 3
    H Gustafsson
    Department of Neurochemistry and Neurotoxicology, Stockholm University, Stockholm, SE-106 91, Sweden
    Biochem Biophys Res Commun 287:1105-11. 2001
    ..We conclude that SH-SY5Y cells express UCP3 natively and that the expression is regulated by IGF-I via the IGF-I receptor...
  10. ncbi request reprint Development of a sensory neuronal cell model for the estimation of mild eye irritation
    Johanna Lilja
    Department of Neurochemistry and Neurotoxicology, University of Stockholm, Sweden
    Altern Lab Anim 32:339-43. 2004
    ..If this method is successfully validated with standardised reference chemicals, the model could complete the test battery of in vitro alternatives, resulting in the saving of thousands of laboratory animals...
  11. ncbi request reprint Insulin-like growth factor type 1 prevents hyperglycemia-induced uncoupling protein 3 down-regulation and oxidative stress
    Helena Gustafsson
    Department of Neurochemistry and Neurotoxicology, Stockholm University, Stockholm, Sweden
    J Neurosci Res 77:285-91. 2004
    ..These data indicate that IGF-1 may protect from hyperglycemia-induced oxidative stress and neuronal injuries by regulating MMP, possibly by the involvement of UCP3...
  12. ncbi request reprint Signalling pathways for insulin-like growth factor type 1-mediated expression of uncoupling protein 3
    Helena Gustafsson
    Department of Neurochemistry and Neurotoxicology, Stockholm University, Stockholm, Sweden
    J Neurochem 88:462-8. 2004
    ..We conclude that IGF-1 enhanced UCP3 expression at transcriptional level, primarily through the PI3-kinase-dependent pathway and partly through the MAP kinase pathway...
  13. ncbi request reprint Insulin and insulin-like growth factor type-I up-regulate the vanilloid receptor-1 (TRPV1) in stably TRPV1-expressing SH-SY5Y neuroblastoma cells
    Johanna Lilja
    Department of Neurochemistry, Stockholm University, Stockholm, Sweden
    J Neurosci Res 85:1413-9. 2007
    ..We conclude that IGF-I and insulin enhance TRPV1 protein expression and activity, and impaired pain sensation might result from distorted TRPV1 regulation in the peripheral nervous system...
  14. ncbi request reprint Surfactant-induced TRPV1 activity--a novel mechanism for eye irritation?
    Johanna Lilja
    Department of Neurochemistry, Stockholm University, SE 106 91 Stockholm, Sweden
    Toxicol Sci 99:174-80. 2007
    ..These results reveal a novel mechanistic pathway for surfactant-induced nociception, which may be an important endpoint in in vitro test batteries as alternatives to Draize's rabbit eye test for classification of eye irritating products...
  15. ncbi request reprint Glutathione intensifies gliotoxin-induced cytotoxicity in human neuroblastoma SH-SY5Y cells
    V Axelsson
    Viktoria Axelsson, Department of Neurochemistry, Stockholm University, SE 106 91, Stockholm, Sweden
    Cell Biol Toxicol 22:127-36. 2006
    ..These results indicate that glutathione promotes gliotoxin-induced cytotoxicity, probably by reducing the ETP (epipolythiodioxopiperazine) disulfide bridge to the dithiol form...
  16. doi request reprint Neurofunctional endpoints assessed in human neuroblastoma SH-SY5Y cells for estimation of acute systemic toxicity
    Helena Gustafsson
    Department of Neurochemistry, The Arrhenius Laboratories for Natural Sciences, Stockholm University, SE 106 91 Stockholm, Sweden
    Toxicol Appl Pharmacol 245:191-202. 2010
    ..Due to the high sensitivity and the simplicity of the test protocol, the CMP assay constitutes a good candidate assay to be included in an in vitro test strategy for prediction of acute systemic toxicity...
  17. ncbi request reprint Cytotoxic response of Aspergillus fumigatus-produced mycotoxins on growth medium, maize and commercial animal feed substrates
    V Wenehed
    Department of Neurochemistry and Neurotoxicology, Stockholm University, SE 106 91 Stockholm, Sweden
    Food Chem Toxicol 41:395-403. 2003
    ..Furthermore, the neurite degeneration of gliotoxin has to be investigated for estimation of a potentially neurotoxic risk...
  18. ncbi request reprint In vitro toxicity: mechanisms, alternatives and validation - a report from the 19th annual scientific meeting of the Scandinavian Society for Cell Toxicology
    Anna Forsby
    Department of Neurochemistry and Neurotoxicology, University of Stockholm, 106 91 Stockholm, Sweden
    Altern Lab Anim 30:307-8. 2002
    ..The meeting consisted of four sessions: mechanisms of toxicity; environmental toxicological testing; alternatives to animal experiments; and validation of in vitro tests...
  19. doi request reprint DNA low-density array analysis of colchicine neurotoxicity in rat cerebellar granular neurons
    Marc Yeste-Velasco
    Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Neurotoxicology 29:309-17. 2008
    ..Present data may help to a better understanding of the molecular mechanisms involved in cytoskeletal degradation-induced apoptosis in neurons...
  20. ncbi request reprint The integrated acute systemic toxicity project (ACuteTox) for the optimisation and validation of alternative in vitro tests
    Cecilia Clemedson
    Expertrådet Environmental Competence AB, Sollentuna, Sweden
    Altern Lab Anim 35:33-8. 2007
    ....
  21. ncbi request reprint Cytotoxicity of amino alcohols to rat hepatoma-derived Fa32 cells
    Ellen M Scheers
    Laboratory of Biochemical Toxicology, Institute of Public Health, Wytsmanstraat 14, 1050 Brussels, Belgium
    Altern Lab Anim 30:309-12. 2002
    ..Decreased toxicity was found for most of the chemicals administered to vitamin E-enriched cells, indicating that reactive oxygen species could be involved in the toxicity of the amino alcohols...
  22. ncbi request reprint Blood-brain barrier in vitro models and their application in toxicology. The report and recommendations of ECVAM Workshop 49
    Pilar Prieto
    ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, 21020 Ispra VA, Italy
    Altern Lab Anim 32:37-50. 2004