Research Topics
| A ForsbySummaryAffiliation: Stockholm University Country: Sweden Publications
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Detail Information
Publications
Using novel in vitro NociOcular assay based on TRPV1 channel activation for prediction of eye sting potential of baby shampoosAnna Forsby
Department of Neurochemistry, The Arrhenius Laboratories for Natural Science, Stockholm University, SE 10691 Stockholm, Sweden
Toxicol Sci 129:325-31. 2012..Our data support that the TRPV1 channel is a principal mediator of eye-stinging sensation induced by baby bath and shampoo formulations and that the NociOcular test may be a valuable in vitro tool to predict human eye-stinging sensation...- Neuronal in vitro models for the estimation of acute systemic toxicityA Forsby
Department of Neurochemistry, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden
Toxicol In Vitro 23:1564-9. 2009.... 
Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicityAnna Forsby
Department of Neurochemistry, Svante Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden
Hum Exp Toxicol 26:333-8. 2007..Our results indicate that it is possible to estimate LOEDs by integrating in vitro toxicity data as surrogates for lowest observed target tissue levels with PBBK models, provided that some knowledge about toxic mechanisms is known...- Polygodial induces inositol phosphate turnover in human neuroblastoma SH-SY5Y cellsA Forsby
Department of Neurochemistry and Neurotoxicology, Stockholm University, Sweden
Neurosci Lett 217:50-4. 1996.... - Gliotoxin induces caspase-dependent neurite degeneration and calpain-mediated general cytotoxicity in differentiated human neuroblastoma SH-SY5Y cellsV Axelsson
Department of Neurochemistry, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Sweden
Biochem Biophys Res Commun 345:1068-74. 2006..These results show that calpains and caspases have a role in the toxicity of gliotoxin in differentiated SH-SY5Y cells and that the process may be Ca(2+)-mediated... - Acrylamide-induced effects on general and neurospecific cellular functions during exposure and recoveryM Nordin-Andersson
Stockholm University, Department of Neurochemistry and Neurotoxicology, Stockholm, Sweden
Cell Biol Toxicol 19:43-51. 2003.... - TRPV1 expression and activity during retinoic acid-induced neuronal differentiationJohanna El Andaloussi-Lilja
Department of Neurochemistry, Stockholm University, Svante Arrhenius väg 21 A, SE 106 91 Stockholm, Sweden
Neurochem Int 55:768-74. 2009..The results show that TRPV1 protein expression increases during RA-induced differentiation in vitro, which generates an altered intracellular Ca(2+) homeostasis... - Anionic linear aliphatic surfactants activate TRPV1: a possible endpoint for estimation of detergent induced eye nociception?H Lindegren
Department of Neurochemistry, Stockholm University, Stockholm, Sweden
Toxicol In Vitro 23:1472-6. 2009..These results reveal a new mechanistic pathway for surfactant-induced nociception... - Insulin-like growth factor type 1 upregulates uncoupling protein 3H Gustafsson
Department of Neurochemistry and Neurotoxicology, Stockholm University, Stockholm, SE-106 91, Sweden
Biochem Biophys Res Commun 287:1105-11. 2001..We conclude that SH-SY5Y cells express UCP3 natively and that the expression is regulated by IGF-I via the IGF-I receptor... - Development of a sensory neuronal cell model for the estimation of mild eye irritationJohanna Lilja
Department of Neurochemistry and Neurotoxicology, University of Stockholm, Sweden
Altern Lab Anim 32:339-43. 2004..If this method is successfully validated with standardised reference chemicals, the model could complete the test battery of in vitro alternatives, resulting in the saving of thousands of laboratory animals... - Insulin-like growth factor type 1 prevents hyperglycemia-induced uncoupling protein 3 down-regulation and oxidative stressHelena Gustafsson
Department of Neurochemistry and Neurotoxicology, Stockholm University, Stockholm, Sweden
J Neurosci Res 77:285-91. 2004..These data indicate that IGF-1 may protect from hyperglycemia-induced oxidative stress and neuronal injuries by regulating MMP, possibly by the involvement of UCP3... - Signalling pathways for insulin-like growth factor type 1-mediated expression of uncoupling protein 3Helena Gustafsson
Department of Neurochemistry and Neurotoxicology, Stockholm University, Stockholm, Sweden
J Neurochem 88:462-8. 2004..We conclude that IGF-1 enhanced UCP3 expression at transcriptional level, primarily through the PI3-kinase-dependent pathway and partly through the MAP kinase pathway... - Insulin and insulin-like growth factor type-I up-regulate the vanilloid receptor-1 (TRPV1) in stably TRPV1-expressing SH-SY5Y neuroblastoma cellsJohanna Lilja
Department of Neurochemistry, Stockholm University, Stockholm, Sweden
J Neurosci Res 85:1413-9. 2007..We conclude that IGF-I and insulin enhance TRPV1 protein expression and activity, and impaired pain sensation might result from distorted TRPV1 regulation in the peripheral nervous system... - Surfactant-induced TRPV1 activity--a novel mechanism for eye irritation?Johanna Lilja
Department of Neurochemistry, Stockholm University, SE 106 91 Stockholm, Sweden
Toxicol Sci 99:174-80. 2007..These results reveal a novel mechanistic pathway for surfactant-induced nociception, which may be an important endpoint in in vitro test batteries as alternatives to Draize's rabbit eye test for classification of eye irritating products... - Glutathione intensifies gliotoxin-induced cytotoxicity in human neuroblastoma SH-SY5Y cellsV Axelsson
Viktoria Axelsson, Department of Neurochemistry, Stockholm University, SE 106 91, Stockholm, Sweden
Cell Biol Toxicol 22:127-36. 2006..These results indicate that glutathione promotes gliotoxin-induced cytotoxicity, probably by reducing the ETP (epipolythiodioxopiperazine) disulfide bridge to the dithiol form... - Neurofunctional endpoints assessed in human neuroblastoma SH-SY5Y cells for estimation of acute systemic toxicityHelena Gustafsson
Department of Neurochemistry, The Arrhenius Laboratories for Natural Sciences, Stockholm University, SE 106 91 Stockholm, Sweden
Toxicol Appl Pharmacol 245:191-202. 2010..Due to the high sensitivity and the simplicity of the test protocol, the CMP assay constitutes a good candidate assay to be included in an in vitro test strategy for prediction of acute systemic toxicity... - Cytotoxic response of Aspergillus fumigatus-produced mycotoxins on growth medium, maize and commercial animal feed substratesV Wenehed
Department of Neurochemistry and Neurotoxicology, Stockholm University, SE 106 91 Stockholm, Sweden
Food Chem Toxicol 41:395-403. 2003..Furthermore, the neurite degeneration of gliotoxin has to be investigated for estimation of a potentially neurotoxic risk... - In vitro toxicity: mechanisms, alternatives and validation - a report from the 19th annual scientific meeting of the Scandinavian Society for Cell ToxicologyAnna Forsby
Department of Neurochemistry and Neurotoxicology, University of Stockholm, 106 91 Stockholm, Sweden
Altern Lab Anim 30:307-8. 2002..The meeting consisted of four sessions: mechanisms of toxicity; environmental toxicological testing; alternatives to animal experiments; and validation of in vitro tests... - DNA low-density array analysis of colchicine neurotoxicity in rat cerebellar granular neuronsMarc Yeste-Velasco
Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
Neurotoxicology 29:309-17. 2008..Present data may help to a better understanding of the molecular mechanisms involved in cytoskeletal degradation-induced apoptosis in neurons... - The integrated acute systemic toxicity project (ACuteTox) for the optimisation and validation of alternative in vitro testsCecilia Clemedson
Expertrådet Environmental Competence AB, Sollentuna, Sweden
Altern Lab Anim 35:33-8. 2007.... - Cytotoxicity of amino alcohols to rat hepatoma-derived Fa32 cellsEllen M Scheers
Laboratory of Biochemical Toxicology, Institute of Public Health, Wytsmanstraat 14, 1050 Brussels, Belgium
Altern Lab Anim 30:309-12. 2002..Decreased toxicity was found for most of the chemicals administered to vitamin E-enriched cells, indicating that reactive oxygen species could be involved in the toxicity of the amino alcohols... - Blood-brain barrier in vitro models and their application in toxicology. The report and recommendations of ECVAM Workshop 49Pilar Prieto
ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, 21020 Ispra (VA, Italy
Altern Lab Anim 32:37-50. 2004