Par Stattin

Summary

Country: Sweden

Publications

  1. pmc Prostate cancer, insulin, and androgen deprivation therapy
    P Stattin
    Br J Cancer 89:1814-5; author reply 1815. 2003
  2. pmc Prostate cancer imaging trends after a nationwide effort to discourage inappropriate prostate cancer imaging
    Danil V Makarov
    US Department of Veterans Affairs, New York University, New York, NY, USA
    J Natl Cancer Inst 105:1306-13. 2013
  3. ncbi request reprint Prostate cancer mortality in areas with high and low prostate cancer incidence
    Par Stattin
    Affiliations of authors Department of Surgery and Perioperative Sciences, Urology and Andrology PS, BH and Department of Radiation Sciences, Oncology HJ, Umea University, Umea, Sweden Department of Surgery, Urology Service PS, SC, Department of Epidemiology and Biostatistics AV, Department of Laboratory Medicine HL, Department of Surgery HL, and Department of Medicine HL, Memorial Sloan Kettering Cancer Center, New York, NY Department of Urology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden SC, JH Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK HL Institute of Biomedical Technology, University of Tampere, Tampere, Finland HL Department of Laboratory Medicine in Malmö, Lund University, Malmo, Sweden HL
    J Natl Cancer Inst 106:dju007. 2014
  4. ncbi request reprint Plasma leptin and colorectal cancer risk: a prospective study in Northern Sweden
    Par Stattin
    Department of Urology, Umea University Hospital, 901 85 Umea, Sweden
    Oncol Rep 10:2015-21. 2003
  5. ncbi request reprint High levels of circulating testosterone are not associated with increased prostate cancer risk: a pooled prospective study
    Par Stattin
    Department of Urology, Umea University Hospital, Umea, Sweden
    Int J Cancer 108:418-24. 2004
  6. ncbi request reprint Non-systematic screening for prostate cancer in Sweden--survey from the National Prostate Cancer Registry
    Par Stattin
    Department of Urology and Andrology, Umea University Hospital, Umea, Sweden
    Scand J Urol Nephrol 37:461-5. 2003
  7. ncbi request reprint Obesity and colon cancer: does leptin provide a link?
    Par Stattin
    Department of Urology and Andrology, Umea University Hospital, Umea, Sweden
    Int J Cancer 109:149-52. 2004
  8. ncbi request reprint High levels of circulating insulin-like growth factor-I increase prostate cancer risk: a prospective study in a population-based nonscreened cohort
    Par Stattin
    Department of Surgery and Perioperative Sciences, Urology and Andrology, Umea University Hospital, 901 85 Umea, Sweden
    J Clin Oncol 22:3104-12. 2004
  9. ncbi request reprint Prospective study of plasma enterolactone and prostate cancer risk (Sweden)
    Par Stattin
    Department of Surgery and Perioperative Sciences, Urology and Andrology, Umed University Hospital, Sweden
    Cancer Causes Control 15:1095-102. 2004
  10. ncbi request reprint Geographical variation in incidence of prostate cancer in Sweden
    Par Stattin
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University Hospital, Umea, Sweden
    Scand J Urol Nephrol 39:372-9. 2005

Collaborators

Detail Information

Publications87

  1. pmc Prostate cancer, insulin, and androgen deprivation therapy
    P Stattin
    Br J Cancer 89:1814-5; author reply 1815. 2003
  2. pmc Prostate cancer imaging trends after a nationwide effort to discourage inappropriate prostate cancer imaging
    Danil V Makarov
    US Department of Veterans Affairs, New York University, New York, NY, USA
    J Natl Cancer Inst 105:1306-13. 2013
    ..We sought to determine the temporal and regional effects of this effort on prostate cancer imaging rates...
  3. ncbi request reprint Prostate cancer mortality in areas with high and low prostate cancer incidence
    Par Stattin
    Affiliations of authors Department of Surgery and Perioperative Sciences, Urology and Andrology PS, BH and Department of Radiation Sciences, Oncology HJ, Umea University, Umea, Sweden Department of Surgery, Urology Service PS, SC, Department of Epidemiology and Biostatistics AV, Department of Laboratory Medicine HL, Department of Surgery HL, and Department of Medicine HL, Memorial Sloan Kettering Cancer Center, New York, NY Department of Urology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden SC, JH Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK HL Institute of Biomedical Technology, University of Tampere, Tampere, Finland HL Department of Laboratory Medicine in Malmö, Lund University, Malmo, Sweden HL
    J Natl Cancer Inst 106:dju007. 2014
    ..We investigated the association between prostate cancer incidence, reflecting uptake of PSA testing, and prostate cancer mortality...
  4. ncbi request reprint Plasma leptin and colorectal cancer risk: a prospective study in Northern Sweden
    Par Stattin
    Department of Urology, Umea University Hospital, 901 85 Umea, Sweden
    Oncol Rep 10:2015-21. 2003
    ..I.=0.72-5.29), whereas no increase was seen for rectal cancer. In women, no association between leptin and risk was seen. These data support the hypothesis that leptin is a risk marker for colorectal cancer in men, but not in women...
  5. ncbi request reprint High levels of circulating testosterone are not associated with increased prostate cancer risk: a pooled prospective study
    Par Stattin
    Department of Urology, Umea University Hospital, Umea, Sweden
    Int J Cancer 108:418-24. 2004
    ..bottom quintile of 0.82 (95% CI = 0.60-1.14; p(trend) = 0.44). No support was found for the hypothesis that high levels of circulating androgens within a physiologic range stimulate development and growth of prostate cancer...
  6. ncbi request reprint Non-systematic screening for prostate cancer in Sweden--survey from the National Prostate Cancer Registry
    Par Stattin
    Department of Urology and Andrology, Umea University Hospital, Umea, Sweden
    Scand J Urol Nephrol 37:461-5. 2003
    ..The aim of this study was to investigate the cause of initiating a work-up leading to a diagnosis of prostate cancer, with emphasis on T1c tumours...
  7. ncbi request reprint Obesity and colon cancer: does leptin provide a link?
    Par Stattin
    Department of Urology and Andrology, Umea University Hospital, Umea, Sweden
    Int J Cancer 109:149-52. 2004
    ..Leptin may be directly involved in colon tumorigenesis or it may serve as a sensitive and robust marker of an obesity-induced adverse endocrine environment. Only weak support for an association of insulin with colon cancer was found...
  8. ncbi request reprint High levels of circulating insulin-like growth factor-I increase prostate cancer risk: a prospective study in a population-based nonscreened cohort
    Par Stattin
    Department of Surgery and Perioperative Sciences, Urology and Andrology, Umea University Hospital, 901 85 Umea, Sweden
    J Clin Oncol 22:3104-12. 2004
    ..Insulin-like growth factor-I (IGF-I) stimulates proliferation and inhibits apoptosis in prostate cancer cells, and IGF-I has been associated with increased prostate cancer risk in some, but not all, epidemiologic studies...
  9. ncbi request reprint Prospective study of plasma enterolactone and prostate cancer risk (Sweden)
    Par Stattin
    Department of Surgery and Perioperative Sciences, Urology and Andrology, Umed University Hospital, Sweden
    Cancer Causes Control 15:1095-102. 2004
    ..We studied the association between plasma enterolactone and risk of prostate cancer...
  10. ncbi request reprint Geographical variation in incidence of prostate cancer in Sweden
    Par Stattin
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University Hospital, Umea, Sweden
    Scand J Urol Nephrol 39:372-9. 2005
    ..To investigate the geographical variation in prostate cancer incidence in Sweden, in particular the incidences of screening-detected tumours and curative treatment of prostate cancer...
  11. ncbi request reprint Prospective study of hyperglycemia and cancer risk
    Par Stattin
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University Hospital, 901 85 Umea, Sweden
    Diabetes Care 30:561-7. 2007
    ..To investigate whether hyperglycemia is associated with increased cancer risk...
  12. doi request reprint Surveillance and deferred treatment for localized prostate cancer. Population based study in the National Prostate Cancer Register of Sweden
    Par Stattin
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden
    J Urol 180:2423-9; discussion 2429-30. 2008
    ..To what extent active surveillance and deferred treatment for localized risk prostate cancer are used is unclear. We assessed the use of surveillance and of deferred treatment in a population based, nationwide cohort in Sweden...
  13. pmc Outcomes in localized prostate cancer: National Prostate Cancer Register of Sweden follow-up study
    Par Stattin
    Urology and Andrology, Department of Surgical and Perioperative Science, Umea University Hospital, Umea, Sweden
    J Natl Cancer Inst 102:950-8. 2010
    ..To our knowledge, there are no outcome studies from contemporary population-based cohorts that include data on stage, Gleason score, and serum levels of prostate-specific antigen (PSA)...
  14. ncbi request reprint Plasma leptin is not associated with prostate cancer risk
    Par Stattin
    Department of Urology and Andrology, Umea University Hospital, 901 85 Umea, Sweden
    Cancer Epidemiol Biomarkers Prev 12:474-5. 2003
  15. ncbi request reprint Ratios of IGF-I, IGF binding protein-3, and prostate-specific antigen in prostate cancer detection
    P Stattin
    Department of Urology and Andrology, Umea University Hospital, 901 85 Umea, Sweden
    J Clin Endocrinol Metab 86:5745-8. 2001
    ..It is unlikely that these combinations will improve prostate cancer detection...
  16. ncbi request reprint Circulating insulin-like growth factor-I and benign prostatic hyperplasia--a prospective study
    P Stattin
    Department of Urology and Andrology, Umea University Hospital, Sweden
    Scand J Urol Nephrol 35:122-6. 2001
    ..The IGFBPs regulate the efflux of IGF-I to the extravascular space and the bioavailability of IGF-I within tissues...
  17. ncbi request reprint Plasma prolactin and prostate cancer risk: A prospective study
    P Stattin
    Department of Urology and Andrology, Umea University Hospital, Umea, Sweden
    Int J Cancer 92:463-5. 2001
    ..Elevated circulating levels of prolactin were not related to an increase in prostate cancer risk, indicating that high circulating prolactin is not associated with development of prostate cancer...
  18. ncbi request reprint Plasma insulin-like growth factor-I, insulin-like growth factor-binding proteins, and prostate cancer risk: a prospective study
    P Stattin
    Department of Urology and Andrology, Umea University Hospital, Sweden
    J Natl Cancer Inst 92:1910-7. 2000
    ..In this study, we sought to determine the role of IGF-I as well as IGFBPs-1, -2, and -3 and insulin as possible etiologic factors for prostate cancer...
  19. ncbi request reprint Long-term outcome of conservative therapy in men presenting with voiding symptoms and prostate cancer
    P Stattin
    Department of Urology, Umea University, Sweden
    Eur Urol 32:404-9. 1997
    ..To investigate the outcome of conservative therapy in men presenting with voiding symptoms and prostate cancer...
  20. ncbi request reprint Tumor size, vascular density and proliferation as prognostic markers in GS 6 and GS 7 prostate tumors in patients with long follow-up and non-curative treatment
    Andreas Josefsson
    Medical Biosciences, Pathology, Umea University, SE 901 85 Umea, Sweden
    Eur Urol 48:577-83. 2005
    ..To investigate the prognostic value of potential markers in localized, Gleason score 6 and 7 prostate cancer (PC)...
  21. ncbi request reprint Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels
    Mattias Johansson
    Department of Surgical and Perioperative Sciences, Umea University Hospital, 901 85 Umea, Sweden
    J Clin Endocrinol Metab 92:4820-6. 2007
    ..We recently found a haplotype in the 3' region of the IGF-I gene associated with increased risk of prostate cancer, and we hypothesized that the observed association is mediated by circulating IGF-I...
  22. ncbi request reprint Insulin resistance is inversely related to prostate cancer: a prospective study in Northern Sweden
    Tanja Stocks
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University Hospital, Umea, Sweden
    Int J Cancer 120:2678-86. 2007
    ..Our data suggest that androgens, which are inversely associated with insulin resistance, are important in the early prostate cancer development, whereas insulin resistance related factors may be important for tumour progression...
  23. doi request reprint Prospective study on metabolic factors and risk of prostate cancer
    Christel Häggström
    Department of Surgical and Perioperative Sciences, Umea University Hospital, Umea University, Umea, Sweden
    Cancer 118:6199-206. 2012
    ..There are inconsistent data regarding the association between metabolic factors, separately and combined, and the risk of prostate cancer and death from prostate cancer...
  24. doi request reprint Blood pressure and risk of cancer incidence and mortality in the Metabolic Syndrome and Cancer Project
    Tanja Stocks
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden
    Hypertension 59:802-10. 2012
    ..12 (95% CI: 1.08-1.15) for men and 1.06 (95% CI: 1.02-1.11) for women. These results suggest a small increased cancer risk overall in men with elevated blood pressure level and a higher risk for cancer death in men and women...
  25. doi request reprint Effects of prostate-specific antigen testing on familial prostate cancer risk estimates
    Ola Bratt
    Department of Urology, Helsingborg Hospital, Helsingborg, Sweden
    J Natl Cancer Inst 102:1336-43. 2010
    ..Family history is a strong risk factor for prostate cancer. The aim of this study was to investigate whether increased diagnostic activity is related to the incidence of prostate cancer among brothers of men with prostate cancer...
  26. ncbi request reprint Circulating enterolactone and prostate cancer risk: a Nordic nested case-control study
    Par Stattin
    Department of Urology, Umea University Hospital, Umea, Sweden
    Int J Cancer 99:124-9. 2002
    ..21 (95% CI = 0.91-1.60), 1.02 (95% CI = 0.59-1.76) and 0.87 (95% CI = 0.45-1.67), respectively. No support for the hypothesis that high circulating enterolactone is protective against prostate cancer was found...
  27. ncbi request reprint The National Prostate Cancer Register in Sweden 1998-2002: trends in incidence, treatment and survival
    Eberhard Varenhorst
    Department of Urology, Faculty of Health Sciences, University Hospital Linkoping, Linkoping, Sweden
    Scand J Urol Nephrol 39:117-23. 2005
    ..To provide a descriptive review of the establishment of the National Prostate Cancer Register (NPCR) in Sweden, to present clinical characteristics at diagnosis and to calculate the relative survival of different risk groups after 5 years...
  28. ncbi request reprint Comprehensive evaluation of genetic variation in the IGF1 gene and risk of prostate cancer
    Mattias Johansson
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University Hospital, Umea, Sweden
    Int J Cancer 120:539-42. 2007
    ..Further studies on genetic variations in the IGF1 gene in relation to prostate cancer risk as well as to circulating levels of IGF1 are needed to confirm this novel finding...
  29. ncbi request reprint Metabolic factors and the risk of colorectal cancer in 580,000 men and women in the metabolic syndrome and cancer project (Me-Can)
    Tanja Stocks
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden Institute of Health Sciences, Free University, Amsterdam, The Netherlands
    Cancer 117:2398-407. 2011
    ..The metabolic syndrome (MetS) has been related to an increased risk of colorectal cancer, but the modest size of previous studies precluded detailed characterization of the role of individual MetS factors and their interaction on risk...
  30. ncbi request reprint Plasma insulin, IGF-binding proteins-1 and -2 and risk of colorectal cancer: a prospective study in northern Sweden
    Richard Palmqvist
    Department of Medical Biosciences, Umea University Hospital, Umea, Sweden
    Int J Cancer 107:89-93. 2003
    ..Our results only moderately support a possible relationship of chronic hyperinsulinemia with colon cancer risk...
  31. pmc Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, CB1 receptor expression and regulation by IL-4
    Lina Thors
    Pharmacology Unit, Department of Pharmacology and Clinical Neuroscience, Umea University, Umea, Sweden
    PLoS ONE 5:e12275. 2010
    ....
  32. ncbi request reprint Population-based study of prostate-specific antigen testing and prostate cancer detection in clinical practice in northern Sweden
    Björn Pilebro
    Department of Urology, Umea University Hospital, Sweden
    Scand J Urol Nephrol 37:210-2. 2003
    ..The aim of this study was to investigate the pattern of PSA testing in clinical practice for men diagnosed with stage T1c prostate cancer in a region with no formal screening programme...
  33. ncbi request reprint Estrogen receptor beta polymorphism is associated with prostate cancer risk
    Camilla Thellenberg-Karlsson
    Department of Radiation Sciences Oncology, University of Umea, Umea, Sweden
    Clin Cancer Res 12:1936-41. 2006
    ..ERbeta is thought to exert an antiproliferative and proapoptotic effect. We examined whether sequence variants in the ERbeta gene are associated with prostate cancer risk...
  34. pmc Prostate cancer increases hyaluronan in surrounding nonmalignant stroma, and this response is associated with tumor growth and an unfavorable outcome
    Andreas Josefsson
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Am J Pathol 179:1961-8. 2011
    ..In conclusion, cancer in the prostate apparently stimulates HA synthesis both in tumor stroma and in the surrounding normal tissue. This promoted tumor growth and was associated with an unfavorable outcome...
  35. doi request reprint Prostate cancer diagnosed after prostate-specific antigen testing of men without clinical signs of the disease: a population-based study from the National Prostate Cancer Register of Sweden
    Ola Bratt
    Department of Urology, Helsingborg Hospital, Lund University, Sweden
    Scand J Urol Nephrol 44:384-90. 2010
    ..To investigate the effects of prostate-specific antigen (PSA) testing of men without clinical signs of prostate cancer on the incidence of prostate cancer in Sweden...
  36. pmc Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival
    Emma Hörnberg
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    PLoS ONE 6:e19059. 2011
    ....
  37. ncbi request reprint Plasma leptin and breast cancer risk: a prospective study in northern Sweden
    Par Stattin
    Department of Urology and Andrology, Umea University Hospital, Umea, Sweden
    Breast Cancer Res Treat 86:191-6. 2004
    ..Obesity is associated with risk of breast cancer after menopause. Circulating levels of leptin are high in obesity and leptin stimulates growth of breast cancer cells...
  38. ncbi request reprint Inherited variation in hormone-regulating genes and prostate cancer survival
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Clin Cancer Res 13:5156-61. 2007
    ..However, little is known about genetic determinants of disease progression and prostate cancer-specific death...
  39. ncbi request reprint Analysis of the macrophage scavenger receptor 1 gene in Swedish hereditary and sporadic prostate cancer
    Fredrik Lindmark
    Department of Radiation Sciences, Oncology, University of Umea, Umea, Sweden
    Prostate 59:132-40. 2004
    ..Here, we further elucidate the role of MSR1 in both Swedish families with HPC and in a cohort of unselected prostate cancer...
  40. ncbi request reprint Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study
    Johan Hultdin
    Department of Medical Biosciences, Clinical Chemistry, Umea University Hospital, Umea, Sweden
    Int J Cancer 113:819-24. 2005
    ..On the contrary, vitamin B12, associated with an up to 3-fold increase in risk, and possibly also folate, may even stimulate prostate cancer development. These findings are novel and should be explored further in future studies...
  41. doi request reprint The UGT2B17 gene deletion is not associated with prostate cancer risk
    Mats Olsson
    Department of Urology, Karolinska University Hospital, Stockholm, Sweden
    Prostate 68:571-5. 2008
    ..Here we determine the risk in a large-scale population-based case-control study...
  42. doi request reprint Nationwide population-based study on 30-day mortality after radical prostatectomy in Sweden
    Sigrid Carlsson
    Department of Urology, Sahlgrenska University Hospital, Gothenburg, Sweden
    Scand J Urol Nephrol 43:350-6. 2009
    ..Radical prostatectomy (RP) is currently commonly performed, either within or outside large high-volume centres. The aim of this study was to assess the 30-day mortality rate after RP in Sweden...
  43. ncbi request reprint Nuclear androgen receptors recur in the epithelial and stromal compartments of malignant and non-malignant human prostate tissue several months after castration therapy
    Pernilla Wikstrom
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Prostate 67:1277-84. 2007
    ....
  44. doi request reprint PCBaSe Sweden: a register-based resource for prostate cancer research
    Eva Hagel
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden
    Scand J Urol Nephrol 43:342-9. 2009
    ..Many topics in clinical prostate cancer epidemiology can be investigated. using PCBaSe Sweden...
  45. pmc Genetic variation in the upstream region of ERG and prostate cancer
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Cancer Causes Control 20:1173-80. 2009
    ..Here, we investigated if inherited genetic variation upstream of ERG alters prostate cancer risk and survival...
  46. ncbi request reprint Angiopoietin 2 expression is related to histological grade, vascular density, metastases, and outcome in prostate cancer
    Anna J Lind
    Departments of Medical Biosciences and Pathology, Umea University, Umea, Sweden
    Prostate 62:394-9. 2005
    ..In several malignant tissues, the angiopoietins are principal regulators of vascular growth and regression, but in normal prostate and prostate tumors the role of the angiopoietins is unknown...
  47. ncbi request reprint Androgens and prostate cancer risk: a prospective study
    Sara Wirén
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden
    Prostate 67:1230-7. 2007
    ..However, some recent studies have shown that a high level of testosterone increase the risk of non-aggressive tumors but is associated with a decreased risk of aggressive tumors...
  48. ncbi request reprint The MTHFR 677C --> T polymorphism and risk of prostate cancer: results from the CAPS study
    Mattias Johansson
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University Hospital, Umea 901 85, Sweden
    Cancer Causes Control 18:1169-74. 2007
    ..In conclusion, our results do not provide strong support for the hypothesis that the MTHFR 677C-->T polymorphism is related to prostate cancer risk...
  49. pmc Metabolic factors associated with risk of renal cell carcinoma
    Christel Häggström
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden
    PLoS ONE 8:e57475. 2013
    ..High levels of BMI, blood pressure, glucose and triglycerides among men and high BMI among women were associated with increased risk of RCC...
  50. doi request reprint Low endoglin vascular density and Ki67 index in Gleason score 6 tumours may identify prostate cancer patients suitable for surveillance
    Andreas Josefsson
    Department of Medical Biosciences, Pathology, Umea University, Sweden
    Scand J Urol Nephrol 46:247-57. 2012
    ..The aim of this study was to explore whether vascular density and tumour cell proliferation are related to the risk of prostate cancer death in patients managed by watchful waiting...
  51. doi request reprint Ischemic heart disease and stroke before and during endocrine treatment for prostate cancer in PCBaSe Sweden
    David Robinson
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Sweden
    Int J Cancer 130:478-87. 2012
    ..Our data underline the importance of a proper indication for ET because many men with low-risk prostate cancer currently receive ET...
  52. doi request reprint Low levels of phosphorylated epidermal growth factor receptor in nonmalignant and malignant prostate tissue predict favorable outcome in prostate cancer patients
    Peter Hammarsten
    Departments of Medical Biosciences, Pathology and Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden
    Clin Cancer Res 16:1245-55. 2010
    ..To explore if the expression of phosphorylated epidermal growth factor receptor (pEGFR) in nonmalignant and malignant prostate tissue is a potential prognostic marker for outcome in prostate cancer patients...
  53. ncbi request reprint H6D polymorphism in macrophage-inhibitory cytokine-1 gene associated with prostate cancer
    Fredrik Lindmark
    Department of Radiation Sciences Oncology, Umea University, Umea, Sweden
    J Natl Cancer Inst 96:1248-54. 2004
    ..We examined whether sequence variants in the MIC-1 gene are associated with the risk of prostate cancer...
  54. doi request reprint Psychiatric treatment in men with prostate cancer--results from a Nation-wide, population-based cohort study from PCBaSe Sweden
    Anna Bill-Axelson
    Department of Urology, University Hospital, Uppsala, Sweden
    Eur J Cancer 47:2195-201. 2011
    ..To explore whether the self-reported psychological distress among men with prostate cancer was to the extent that it required psychiatric treatment...
  55. doi request reprint Pooled cohort study on height and risk of cancer and cancer death
    Sara Wirén
    Department of Surgery and Perioperative Sciences, Urology and Andrology, Umea University, 901 87, Umea, Sweden
    Cancer Causes Control 25:151-9. 2014
    ..To assess the association between height and risk of cancer and cancer death...
  56. ncbi request reprint -160C/A polymorphism in the E-cadherin gene promoter and risk of hereditary, familial and sporadic prostate cancer
    Björn Anders Jonsson
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Int J Cancer 109:348-52. 2004
    ..6; 95% CI = 1.4-4.9). Our data indicate that the -160 single nucleotide polymorphism in CDH1 is a low-penetrant prostate cancer susceptibility gene that might explain a proportion of familial and notably hereditary prostate cancer...
  57. ncbi request reprint Cell proliferation and apoptosis in prostate tumors and adjacent non-malignant prostate tissue in patients at different time-points after castration treatment
    Nina Ohlson
    Department of Medical Biosciences, Pathology, and Surgical and Perioperative Sciences, Umea University, Umea, Sweden
    Prostate 62:307-15. 2005
    ..Androgen ablation is the standard treatment for advanced prostate cancer but the short-term cellular effects are largely unknown...
  58. pmc Phospho-Akt immunoreactivity in prostate cancer: relationship to disease severity and outcome, Ki67 and phosphorylated EGFR expression
    Peter Hammarsten
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    PLoS ONE 7:e47994. 2012
    ....
  59. pmc Metabolomic characterization of human prostate cancer bone metastases reveals increased levels of cholesterol
    Elin Thysell
    Department of Chemistry, Umea University, Umea, Sweden
    PLoS ONE 5:e14175. 2010
    ..Identification of metabolic pathways involved in the growth of bone metastases therefore has the potential to improve PCa prognostication as well as therapy...
  60. doi request reprint Metabolic syndrome and risk of bladder cancer: prospective cohort study in the metabolic syndrome and cancer project (Me-Can)
    Christel Häggström
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden
    Int J Cancer 128:1890-8. 2011
    ..Hypertension and a composite MetS score were significantly but modestly associated with an increased risk of bladder cancer among men and elevated glucose was associated with a nonsignificant increase in risk among women...
  61. doi request reprint Low stroma androgen receptor level in normal and tumor prostate tissue is related to poor outcome in prostate cancer patients
    Pernilla Wikstrom
    Departments of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Prostate 69:799-809. 2009
    ..The role of androgen receptors (ARs) in the prostate tumor cell environment is largely unknown...
  62. ncbi request reprint Rye, lignans and human health
    Goran Hallmans
    Departments of Public Health and Clinical Medicine, University of Umea, Umea, Sweden
    Proc Nutr Soc 62:193-9. 2003
    ..It seems reasonable to assume that these protective effects are associated with one or more factors in the dietary fibre complex...
  63. ncbi request reprint The magnitude of early castration-induced primary tumour regression in prostate cancer does not predict clinical outcome
    Nina Ohlson
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Eur Urol 49:675-83. 2006
    ..This study was designed to test whether early castration-induced short-term cellular changes in primary prostate tumours could predict clinical outcome in advanced disease...
  64. ncbi request reprint Castration-induced epithelial cell death in human prostate tissue is related to locally reduced IGF-1 levels
    Nina Ohlson
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Prostate 67:32-40. 2007
    ..Castration rapidly reduces stroma insulin-like growth factor (IGF)-1 synthesis and action in mouse prostate epithelium. We explore if similar changes are of importance for castration-induced prostate regression in humans...
  65. doi request reprint Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition study
    Mattias Johansson
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, 901 85 Umea, Sweden
    Cancer Epidemiol Biomarkers Prev 17:279-85. 2008
    ..The aim of the present study was to investigate the relationship between prostate cancer risk and circulating concentrations of folate and vitamin B(12) in a large prospective cohort...
  66. ncbi request reprint Leptin is associated with increased prostate cancer risk: a nested case-referent study
    P Stattin
    Department of Urology, , , Sweden
    J Clin Endocrinol Metab 86:1341-5. 2001
    ..A critical fat mass related to an interior milieu favorable for prostate cancer development seems to exist, because intermediate but not high leptin levels are related to prostate cancer risk...
  67. pmc Blood glucose and risk of incident and fatal cancer in the metabolic syndrome and cancer project (me-can): analysis of six prospective cohorts
    Tanja Stocks
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden
    PLoS Med 6:e1000201. 2009
    ..We examined the association between blood glucose and cancer risk in a prospective study of six European cohorts...
  68. ncbi request reprint SELDI-TOF MS versus prostate specific antigen analysis of prospective plasma samples in a nested case-control study of prostate cancer
    Asa Skytt
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Int J Cancer 121:615-20. 2007
    ....
  69. ncbi request reprint Prediction of survival of metastatic prostate cancer based on early serial measurements of prostate specific antigen and alkaline phosphatase
    David Robinson
    Department of Urology, Ryhov County Hospital, Jonkoping, Sweden
    J Urol 179:117-22; discussion 122-3. 2008
    ..We determined how serial measurements of prostate specific antigen and alkaline phosphatase can be used to predict survival early in the course of hormone treated metastatic prostate cancer...
  70. doi request reprint LRIG1 and the liar paradox in prostate cancer: a study of the expression and clinical significance of LRIG1 in prostate cancer
    Marcus Thomasson
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Int J Cancer 128:2843-52. 2011
    ..We propose that LRIG1 is an important determinant of prostate cancer growth, and the implications of its expression on patient outcome depend on the clinical and biological circumstances...
  71. doi request reprint A high cannabinoid CB(1) receptor immunoreactivity is associated with disease severity and outcome in prostate cancer
    Sui Chu Chung
    Department of Pharmacology and Clinical Neuroscience, Pharmacology, Umea University, Umea, Sweden
    Eur J Cancer 45:174-82. 2009
    ..It is concluded that a high tumour CB(1)IR score is associated with prostate cancer severity and outcome...
  72. pmc Mast cells are novel independent prognostic markers in prostate cancer and represent a target for therapy
    Anna Johansson
    Department of Medical Biosciences, Umea University, Umea, Sweden
    Am J Pathol 177:1031-41. 2010
    ..In addition, peritumoral mast cells provide FGF-2 to the tumor micro environment, which may contribute to their stimulating effect on angiogenesis...
  73. ncbi request reprint MRI of the skeleton in prostate cancer staging
    Anders Rydh
    Department of Diagnostic Radiology, Umea University, Sweden
    Scand J Urol Nephrol 37:222-5. 2003
    ..To explore the value of MRI in the detection of bone metastases in newly diagnosed prostate cancer...
  74. ncbi request reprint Decreased pigment epithelium-derived factor is associated with metastatic phenotype in human and rat prostate tumors
    Sofia Halin
    Department of Medical Biosciences, Umea University, Umea, Sweden
    Cancer Res 64:5664-71. 2004
    ..These observations indicate that loss of pigment epithelium-derived factor expression could be associated with the progression toward a metastatic phenotype in prostate cancer...
  75. ncbi request reprint Rye bran diet increases epithelial cell apoptosis and decreases epithelial cell volume in TRAMP (transgenic adenocarcinoma of the mouse prostate) tumors
    Pernilla Wikstrom
    Department of Medical Biosciences, Pathology, Umea University, Sweden
    Nutr Cancer 53:111-6. 2005
    ..There were, however, no significant changes detected in lobe weights or tumor grade. In conclusion, a rye bran diet increases epithelial apoptosis and reduces the epithelial cell fraction in TRAMP tumors...
  76. doi request reprint Suicide risk in men with prostate-specific antigen-detected early prostate cancer: a nationwide population-based cohort study from PCBaSe Sweden
    Anna Bill-Axelson
    Department of Urology, University Hospital, Uppsala, Sweden
    Eur Urol 57:390-5. 2010
    ..The risk of suicide is increased among cancer patients including men with prostate cancer (PCa). However, whether this increased risk applies to men diagnosed subsequent to prostate-specific antigen (PSA) testing is not known...
  77. doi request reprint Parenteral estrogen versus combined androgen deprivation in the treatment of metastatic prostatic cancer: part 2. Final evaluation of the Scandinavian Prostatic Cancer Group (SPCG) Study No. 5
    Per Olov Hedlund
    Department of Urology, Karolinska University Hospital Solna, Sweden
    Scand J Urol Nephrol 42:220-9. 2008
    ..The aim of the study was to compare anticancer efficacy and adverse events, especially cardiovascular events...
  78. doi request reprint Blood pressure, body size and prostate cancer risk in the Swedish Construction Workers cohort
    Tanja Stocks
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden
    Int J Cancer 127:1660-8. 2010
    ..Our study support a positive association between overweight and risk of fatal prostate cancer...
  79. ncbi request reprint Components of the metabolic syndrome and colorectal cancer risk; a prospective study
    T Stocks
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University Hospital, Umea, Sweden
    Int J Obes (Lond) 32:304-14. 2008
    ..To examine the relation of well-known factors of the metabolic syndrome (MetS) as well as related circulating factors, with risk of colorectal cancer...
  80. ncbi request reprint p53 expression in correlation to clinical outcome in patients with renal cell carcinoma
    B Ljungberg
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Sweden
    Scand J Urol Nephrol 35:15-20. 2001
    ..The aim of this study was to evaluate the role of p53 as prognostic factor in renal cell carcinoma (RCC) and its relation to clinicopathological factors...
  81. ncbi request reprint Endoglin (CD105) is expressed on immature blood vessels and is a marker for survival in prostate cancer
    Pernilla Wikstrom
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Prostate 51:268-75. 2002
    ..In this study, endoglin was evaluated as a prognostic factor for prostate cancer progression...
  82. doi request reprint Androgens and prostate cancer risk
    Sara Wirén
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, SE 901 85 Umea, Sweden
    Best Pract Res Clin Endocrinol Metab 22:601-13. 2008
    ..One small placebo-controlled study showed no increase in incidence of prostate cancer after 6 months of testosterone therapy, but data on the safety of testosterone replacement therapy remain limited...
  83. ncbi request reprint Transrectal core biopsy trauma may increase cell proliferation in prostate tumors
    A Bergh
    Department of Pathology, Umea University, Umea, Sweden
    Scand J Urol Nephrol 36:311-3. 2002
    ..Further studies are needed to evaluate the clinical significance of this observation...
  84. ncbi request reprint Germline mutations in E-cadherin do not explain association of hereditary prostate cancer, gastric cancer and breast cancer
    Björn Anders Jonsson
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Int J Cancer 98:838-43. 2002
    ..In a family with hereditary gastric cancer of the diffuse type, we identified the first truncating germline mutation in a Scandinavian family...
  85. ncbi request reprint Gonadotropin-releasing hormone receptor expression in the human prostate
    P Stattin
    Institute of Surgical and Perioperative Sciences, Urology and Andrology, , , Sweden
    Prostate 47:276-84. 2001
    ..Comparative data show relatively high GnRH-R expression in human prostate tissue compared to other human tissues...
  86. pmc Short-term cellular effects induced by castration therapy in relation to clinical outcome in prostate cancer
    P Stattin
    Department of Urology and Andrology, , Sweden
    Br J Cancer 77:670-5. 1998
    ..These data suggest that it might be possible to predict the effect of castration therapy by examining tumour biopsies shortly after treatment...
  87. ncbi request reprint Castration-induced reduction of vascular endothelial growth factor expression in benign human prostate tissue is lost in advanced prostate cancer
    S Häggström
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University, Umea, Sweden
    BJU Int 88:110-6. 2001
    ....