Håkan Alfredson

Summary

Affiliation: Sports Medicine
Country: Sweden

Publications

  1. ncbi request reprint Chronic Achilles tendinosis: recommendations for treatment and prevention
    H Alfredson
    Department of Surgical and Perioperative Science, Umea University, Sweden
    Sports Med 29:135-46. 2000
  2. pmc Ultrasound guided sclerosis of neovessels in painful chronic Achilles tendinosis: pilot study of a new treatment
    Lars Ohberg
    Department of Diagnostic Radiology, University of Umea, S 901 85 Umea, Sweden
    Br J Sports Med 36:173-5; discussion 176-7. 2002
  3. ncbi request reprint Intratendinous glutamate levels and eccentric training in chronic Achilles tendinosis: a prospective study using microdialysis technique
    Håkan Alfredson
    Sports Medicine Unit, Department of Surgical and Perioperative Science, Umea University, 90187 Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 11:196-9. 2003
  4. ncbi request reprint Chronic tendon pain--implications for treatment: an update
    Håkan Alfredson
    Umea University, Department of Surgical and Perioperative Science, Sports Medicine, Umea, Sweden
    Curr Drug Targets 5:407-10. 2004
  5. ncbi request reprint Sclerosing injections to areas of neo-vascularisation reduce pain in chronic Achilles tendinopathy: a double-blind randomised controlled trial
    Håkan Alfredson
    Department of Surgical and Perioperative Science Sports Medicine, Centre for Musculoskeletal Research, National Institute for Working Life, University of Umea, 90187, Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 13:338-44. 2005
  6. pmc Asymptomatic Achilles tendon pathology is associated with a central fat distribution in men and a peripheral fat distribution in women: a cross sectional study of 298 individuals
    James E Gaida
    School of Exercise and Nutrition Sciences, Deakin University, Burwood, Australia
    BMC Musculoskelet Disord 11:41. 2010
  7. ncbi request reprint In situ microdialysis in tendon tissue: high levels of glutamate, but not prostaglandin E2 in chronic Achilles tendon pain
    H Alfredson
    Department of Surgical and Perioperative Science, Umea University, Sweden
    Knee Surg Sports Traumatol Arthrosc 7:378-81. 1999
  8. ncbi request reprint High intratendinous lactate levels in painful chronic Achilles tendinosis. An investigation using microdialysis technique
    Håkan Alfredson
    Department of Surgical and Perioperative Science, Umea University, Sweden
    J Orthop Res 20:934-8. 2002
  9. ncbi request reprint Sclerosing polidocanol injections to treat chronic painful shoulder impingement syndrome-results of a two-centre collaborative pilot study
    Håkan Alfredson
    Department of Surgical and Perioperative Science, Sports Medicine Unit, University of Umea, 901 87 Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 14:1321-6. 2006
  10. ncbi request reprint Is vasculo-neural ingrowth the cause of pain in chronic Achilles tendinosis? An investigation using ultrasonography and colour Doppler, immunohistochemistry, and diagnostic injections
    Håkan Alfredson
    Department of Surgical and Perioperative Science, Sports Medicine, University of Umea, S 90187, Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 11:334-8. 2003

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Chronic Achilles tendinosis: recommendations for treatment and prevention
    H Alfredson
    Department of Surgical and Perioperative Science, Umea University, Sweden
    Sports Med 29:135-46. 2000
    ..Calf muscle strength takes a long time to recover and, furthermore, a prolonged progressive calcaneal bone loss has been shown on the operated side up to 1 year after surgical treatment...
  2. pmc Ultrasound guided sclerosis of neovessels in painful chronic Achilles tendinosis: pilot study of a new treatment
    Lars Ohberg
    Department of Diagnostic Radiology, University of Umea, S 901 85 Umea, Sweden
    Br J Sports Med 36:173-5; discussion 176-7. 2002
    ..The mechanism that causes pain in chronic Achilles tendinosis is not known. However, high resolution colour Doppler ultrasound has shown that neovascularisation may be involved...
  3. ncbi request reprint Intratendinous glutamate levels and eccentric training in chronic Achilles tendinosis: a prospective study using microdialysis technique
    Håkan Alfredson
    Sports Medicine Unit, Department of Surgical and Perioperative Science, Umea University, 90187 Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 11:196-9. 2003
    ..Our results offer no obvious neurophysiological explanation but showed that successful treatment with eccentric training was not associated with lowered intratendinous glutamate levels...
  4. ncbi request reprint Chronic tendon pain--implications for treatment: an update
    Håkan Alfredson
    Umea University, Department of Surgical and Perioperative Science, Sports Medicine, Umea, Sweden
    Curr Drug Targets 5:407-10. 2004
    ....
  5. ncbi request reprint Sclerosing injections to areas of neo-vascularisation reduce pain in chronic Achilles tendinopathy: a double-blind randomised controlled trial
    Håkan Alfredson
    Department of Surgical and Perioperative Science Sports Medicine, Centre for Musculoskeletal Research, National Institute for Working Life, University of Umea, 90187, Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 13:338-44. 2005
    ..In summary, injections with the sclerosing substance Polidocanol have the potential to reduce tendon pain during activity in patients with chronic painful mid-portion Achilles tendinopathy...
  6. pmc Asymptomatic Achilles tendon pathology is associated with a central fat distribution in men and a peripheral fat distribution in women: a cross sectional study of 298 individuals
    James E Gaida
    School of Exercise and Nutrition Sciences, Deakin University, Burwood, Australia
    BMC Musculoskelet Disord 11:41. 2010
    ..Therefore, the purpose of this study was to determine whether fat distribution was associated with asymptomatic Achilles tendon pathology...
  7. ncbi request reprint In situ microdialysis in tendon tissue: high levels of glutamate, but not prostaglandin E2 in chronic Achilles tendon pain
    H Alfredson
    Department of Surgical and Perioperative Science, Umea University, Sweden
    Knee Surg Sports Traumatol Arthrosc 7:378-81. 1999
    ..Furthermore, there were no signs of inflammation in the tendons with painful nodules, as indicated by the normal prostaglandin E2 levels...
  8. ncbi request reprint High intratendinous lactate levels in painful chronic Achilles tendinosis. An investigation using microdialysis technique
    Håkan Alfredson
    Department of Surgical and Perioperative Science, Umea University, Sweden
    J Orthop Res 20:934-8. 2002
    ..The importance of this finding for the pathogenesis and pain mechanisms in this chronic condition needs to be further investigated...
  9. ncbi request reprint Sclerosing polidocanol injections to treat chronic painful shoulder impingement syndrome-results of a two-centre collaborative pilot study
    Håkan Alfredson
    Department of Surgical and Perioperative Science, Sports Medicine Unit, University of Umea, 901 87 Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 14:1321-6. 2006
    ..05). In the short-term perspective, sclerosing polidocanol injections targeting the neovessels in the supraspinatus tendon and/or bursa wall seems to have a potential to reduce the pain during shoulder loading activity...
  10. ncbi request reprint Is vasculo-neural ingrowth the cause of pain in chronic Achilles tendinosis? An investigation using ultrasonography and colour Doppler, immunohistochemistry, and diagnostic injections
    Håkan Alfredson
    Department of Surgical and Perioperative Science, Sports Medicine, University of Umea, S 90187, Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 11:334-8. 2003
    ..In conclusion, we demonstrate findings which support neovessels and accompanying nerves being the possible source of pain in chronic mid-portion Achilles tendinosis...
  11. ncbi request reprint cDNA-arrays and real-time quantitative PCR techniques in the investigation of chronic Achilles tendinosis
    Håkan Alfredson
    Department of Surgical and Perioperative Science, Sports Medicine Unit, University of Umea, S 901 87 Umea, Sweden
    J Orthop Res 21:970-5. 2003
    ..In conclusion, cDNA-arrays and real-time PCR can be used to study differences in gene expression levels between tendinosis and control tendon tissue...
  12. ncbi request reprint Chronic midportion Achilles tendinopathy: an update on research and treatment
    Håkan Alfredson
    Sports Medicine Unit, Department of Surgical and Perioperative Science, Umea University, 901 87 Umea, Sweden
    Clin Sports Med 22:727-41. 2003
    ..Also, very recently, a new method consisting of sclerosing of neovessels in the area with painful tendinosis showed promising short-term results. Ongoing and future research will evaluate the potential of these treatment models...
  13. ncbi request reprint Neovascularisation in chronic painful patellar tendinosis--promising results after sclerosing neovessels outside the tendon challenge the need for surgery
    Håkan Alfredson
    Sports Medicine Unit, Department of Surgical and Perioperative Science, University of Umea, 90187 Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 13:74-80. 2005
    ....
  14. ncbi request reprint The chronic painful Achilles and patellar tendon: research on basic biology and treatment
    Håkan Alfredson
    Sports Medicine Unit, Department of Surgical and Perioperative Science, Umea University, Umea, Sweden
    Scand J Med Sci Sports 15:252-9. 2005
    ..A recent, randomized, double-blind study verified the importance of injecting the sclerosing substance Polidocanol...
  15. ncbi request reprint Conservative management of Achilles tendinopathy: new ideas
    Håkan Alfredson
    Sports Medicine Unit, Department of Surgical and Perioperative Science, Umea University, 90187 Umea, Sweden
    Foot Ankle Clin 10:321-9. 2005
    ..This article gives an update on recently developed conservative treatment methods for the management of chronic Achilles tendinopathy...
  16. ncbi request reprint Sclerosing polidocanol injections of small vessels to treat the chronic painful tendon
    H Alfredson
    Sports Medicine Unit, University of Umea, 901 87 Umea, Sweden
    Cardiovasc Hematol Agents Med Chem 5:97-100. 2007
    ..Whether the effects of polidocanol are mediated through destruction of neovessels, activity on nerves or a combination, is under evaluation...
  17. ncbi request reprint Treatment of midportion Achilles tendinosis: similar clinical results with US and CD-guided surgery outside the tendon and sclerosing polidocanol injections
    Håkan Alfredson
    Department of Surgical and Perioperative Science Sports Medicine, Sports Medicine Unit, University of Umea, 901 87 Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 15:1504-9. 2007
    ..In summary, both treatment with sclerosing polidocanol injections and open surgical revision outside the ventral Achilles midportion show promising short-term clinical results...
  18. ncbi request reprint Chronic tendon pain: no signs of chemical inflammation but high concentrations of the neurotransmitter glutamate. Implications for treatment?
    Håkan Alfredson
    Umea University, Department of Surgical and Perioperative Science, Centre for Musculoskeletal Research, National Institute for Working Life, Sweden
    Curr Drug Targets 3:43-54. 2002
    ..The findings of glutamate and it's NMDARI-receptors might have implications for treatment and be a potential target for drugs...
  19. doi request reprint Ultrasound and Doppler-guided mini-surgery to treat midportion Achilles tendinosis: results of a large material and a randomised study comparing two scraping techniques
    Håkan Alfredson
    Department of Surgical and Perioperative Science Sports Medicine, University of Umea, Sweden
    Br J Sports Med 45:407-10. 2011
    ..In a randomised study on a small patient material, similar short-term clinical results were demonstrated with surgery outside the tendon and sclerosing polidocanol injections, but surgical treatment led to a faster return to activity...
  20. ncbi request reprint In vivo investigation of ECRB tendons with microdialysis technique--no signs of inflammation but high amounts of glutamate in tennis elbow
    H Alfredson
    Department of Surgical and Perioperative Science, Umea University, Sweden
    Acta Orthop Scand 71:475-9. 2000
    ..Our findings indicate involvement of the excitatory neurotransmitter glutamate, but no biochemical signs of inflammation (normal PGE2 levels) in ECRB tendons from patients with tennis elbow...
  21. ncbi request reprint Glutamate NMDAR1 receptors localised to nerves in human Achilles tendons. Implications for treatment?
    H Alfredson
    Sports Medicine, Department of Surgical and Perioperative Science, University of Umea, 901 87 Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 9:123-6. 2001
    ..Our present finding of glutamate NMDA receptors in human Achilles tendons might have implications for pain treatment...
  22. doi request reprint Midportion Achilles tendinosis and the plantaris tendon
    Håkan Alfredson
    Department of Surgical and Perioperative Science Sports Medicine, University of Umea, Sweden
    Br J Sports Med 45:1023-5. 2011
    ..The aim of this study was to investigate the occurrence of a plantaris tendon in close relation to the Achilles tendon in consecutive patients with midportion Achilles tendinosis undergoing treatment with US and Doppler-guided scraping...
  23. doi request reprint Partial mid-portion Achilles tendon ruptures: new sonographic findings helpful for diagnosis
    Håkan Alfredson
    Department of Surgical and Perioperative Science Sports Medicine, University of Umea, Sweden
    Br J Sports Med 45:429-32. 2011
    ..A history including a sudden onset of pain and/or relative weakness in plantar flexion force is an indicator. The most loaded side of the Achilles tendon is the dorsal side (skin side)...
  24. ncbi request reprint In vivo microdialysis and immunohistochemical analyses of tendon tissue demonstrated high amounts of free glutamate and glutamate NMDAR1 receptors, but no signs of inflammation, in Jumper's knee
    H Alfredson
    Department of Surgical and Perioperative Sciences, University of Umea, Sweden
    J Orthop Res 19:881-6. 2001
    ..These findings altogether indicate that glutamate might be involved in painful Jumper's knee, and further emphasizes that there is no chemical inflammation (normal PGE2 levels) in this chronic condition...
  25. doi request reprint No normalisation of the tendon structure and thickness after intratendinous surgery for chronic painful midportion Achilles tendinosis
    H Alfredson
    Department of Surgical and Perioperative Sciences, University of Umea, Sweden
    Br J Sports Med 43:948-9. 2009
    ..To characterise Achilles tendon structure and thickness a minimum of 8 years after intratendinous surgery. Material and..
  26. ncbi request reprint Sclerosing polidocanol injections in chronic painful tennis elbow-promising results in a pilot study
    Eva Zeisig
    Sports Medicine Unit, Department of Surgical and Perioperative Science, Umea University, 901 87 Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 14:1218-24. 2006
    ....
  27. doi request reprint Marked sympathetic component in the perivascular innervation of the dorsal paratendinous tissue of the patellar tendon in arthroscopically treated tendinosis patients
    Patrik Danielson
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, 901 87, Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 16:621-6. 2008
    ..The findings are discussed in relation to aspects of vascular regulation, and to pain symptoms of tendinosis...
  28. ncbi request reprint Immunohistochemical and in situ hybridization observations favor a local catecholamine production in the human Achilles tendon
    Dennis Bjur
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, Umea, Sweden
    Histol Histopathol 23:197-208. 2008
    ..It is likely that locally produced catecholamines and the occurrence of autocrine/paracrine effects of these substances are of great relevance during the process of tendinosis...
  29. ncbi request reprint Is the chronic painful tendinosis tendon a strong tendon?: a case study involving an Olympic weightlifter with chronic painful Jumper's knee
    Karl Gisslén
    Department of Surgical and Perioperative Science, Sports Medicine, Umea University, Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 14:897-902. 2006
    ..This case questions previous theories about the weak tendinosis tendon, and stresses the importance of studies evaluating tendon strength...
  30. ncbi request reprint Chronic Achilles tendon pain treated with eccentric calf-muscle training
    Martin Fahlström
    Department of Surgical and Perioperative Sciences, Sports Medicine, Umea University, 90187, Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 11:327-33. 2003
    ..2. Our conclusion is that treatment with eccentric calf-muscle training produced good clinical results in patients with chronic painful mid-portion Achilles tendinosis, but not in patients with chronic insertional Achilles tendon pain...
  31. ncbi request reprint Extensor origin vascularity related to pain in patients with Tennis elbow
    Eva Zeisig
    Department of Surgical and Perioperative Science Sports Medicine, University of Umea, 90187, Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 14:659-63. 2006
    ..Most likely, the findings correspond with the vasculo-neural in growth that has been demonstrated in the chronic painful Achilles tendon, and possibly have implications for treatment...
  32. ncbi request reprint Sclerosing therapy in chronic Achilles tendon insertional pain-results of a pilot study
    Lars Ohberg
    Department of Radiation Sciences, Diagnostic Radiology, Umea University, 90185, Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 11:339-43. 2003
    ..In conclusion, treatment only focusing on sclerosing the area with neovessels showed promising short-term clinical results in this small pilot study. The findings support further studies, preferably in a randomised manner...
  33. ncbi request reprint Distribution of general (PGP 9.5) and sensory (substance P/CGRP) innervations in the human patellar tendon
    Patrik Danielson
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, 901 87 Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 14:125-32. 2006
    ..Particularly it seems as if there is a marked nerve-mediated regulation of the blood vessels supplying the tendon, at the level where they course in the loose paratendinous connective tissue...
  34. ncbi request reprint The innervation pattern of the human Achilles tendon: studies of the normal and tendinosis tendon with markers for general and sensory innervation
    Dennis Bjur
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, SE 901 87, Umea, Sweden
    Cell Tissue Res 320:201-6. 2005
    ..In conclusion, Mechanoreceptors (sensory corpuscles) were occasionally observed, nerve-related components are present in association with blood vessels in both the normal and the tendinosis tendon...
  35. ncbi request reprint Painful conditions in the Achilles tendon region: a common problem in middle-aged competitive badminton players
    Martin Fahlström
    Department of Surgical and Perioperative Science, University of Umea, 90187 Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 10:57-60. 2002
    ..In conclusion, Achilles tendon pain seems to be relatively common among Swedish middle-aged competitive badminton players, particularly in the older ones...
  36. ncbi request reprint Nerve-related characteristics of ventral paratendinous tissue in chronic Achilles tendinosis
    Gustav Andersson
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, 901 87, Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 15:1272-9. 2007
    ..In conclusion, the nerve-related characteristics of the area targeted by the polidicanol injection treatment for Achilles tendinosis, are shown here for the first time...
  37. doi request reprint Presence of substance P and the neurokinin-1 receptor in tenocytes of the human Achilles tendon
    Gustav Andersson
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, SE 901 87 Umea, Sweden
    Regul Pept 150:81-7. 2008
    ..In conclusion, it appears as if SPergic autocrine/paracrine effects occur in tendon tissue during the processes of tendinosis, hitherto unknown effects for human tendons...
  38. ncbi request reprint Extensive expression of markers for acetylcholine synthesis and of M2 receptors in tenocytes in therapy-resistant chronic painful patellar tendon tendinosis - a pilot study
    Patrik Danielson
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, SE 901 87 Umea, Sweden
    Life Sci 80:2235-8. 2007
    ..Thus, the results of this pilot study suggest that non-neuronal ACh is highly involved in the pathology of therapy-resistant patellar tendinosis...
  39. doi request reprint Tenocyte hypercellularity and vascular proliferation in a rabbit model of tendinopathy: contralateral effects suggest the involvement of central neuronal mechanisms
    Gustav Andersson
    Department of Integrative Medical Biology, Anatomy, Umea University, Sweden
    Br J Sports Med 45:399-406. 2011
    ..To determine whether there are objective findings of tendinosis in a rabbit tendinopathy model on exercised and contralateral (non-exercised) Achilles tendons...
  40. ncbi request reprint Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects of importance regarding Achilles tendon tendinosis (tendinopathy)
    Dennis Bjur
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, SE 901 87, Umea, Sweden
    Cell Tissue Res 331:385-400. 2008
    ....
  41. ncbi request reprint Eccentric training in chronic painful impingement syndrome of the shoulder: results of a pilot study
    Per Jonsson
    Department of Surgical and Perioperative Science, Sports Medicine University of Umeå, 90187, Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 14:76-81. 2006
    ..The findings motivate further studies...
  42. ncbi request reprint The plantaris tendon in association with mid-portion Achilles tendinosis: tendinosis-like morphological features and presence of a non-neuronal cholinergic system
    Christoph Spang
    Department of Integrative Medical Biology, Anatomy Section, Umea University, Umea, Sweden
    Histol Histopathol 28:623-32. 2013
    ....
  43. ncbi request reprint Sclerosing polidocanol injections in mid-portion Achilles tendinosis: remaining good clinical results and decreased tendon thickness at 2-year follow-up
    Bengt Lind
    Department of Radiology, University of Umea, 901 87 Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 14:1327-32. 2006
    ..Decreased tendon thickness and improved structure after treatment, might indicate a remodelling potential?..
  44. ncbi request reprint Painful conditions in the Achilles tendon region in elite badminton players
    Martin Fahlström
    Department of Surgical and Perioperative Sciences, Sports Medicine, National Institute for Working Life, University Hospital of Umea, Umea, Sweden
    Am J Sports Med 30:51-4. 2002
    ..There were no differences in age, sex, and body mass index between the players with and without painful conditions in the Achilles tendon region...
  45. ncbi request reprint In situ hybridization studies confirming recent findings of the existence of a local nonneuronal catecholamine production in human patellar tendinosis
    Patrik Danielson
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, SE 901 87 Umea, Sweden
    Microsc Res Tech 70:908-11. 2007
    ..The findings add to recent observations of the occurrence of a local production in tendons of signal substances traditionally related to neurons...
  46. ncbi request reprint Glutamate and prostaglandin E2 in the trapezius muscle of female subjects with chronic muscle pain and controls determined by microdialysis
    Gerd M Flodgren
    Centre for Musculoskeletal Research, University of Gavle, P O Box 7629, S 907 12 Umeå, Sweden
    Eur J Pain 9:511-5. 2005
    ..Further, it revealed that when using the slow-flow method, a period of at least 2.0-2.5 h is needed, after probe insertion, to reach steady state for glutamate and PGE2...
  47. pmc VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes
    Alexander Scott
    Department of Surgical and Perioperative Science, Umea University, Sweden
    J Orthop Res 26:685-92. 2008
    ....
  48. ncbi request reprint Unexpected presence of the neurotrophins NGF and BDNF and the neurotrophin receptor p75 in the tendon cells of the human Achilles tendon
    Johan Bagge
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, Umea, Sweden
    Histol Histopathol 24:839-48. 2009
    ..These interactions may regulate tropic modulatory, and apoptotic effects. In conclusion, the observations show a new concept concerning production and function of neurotrophins, namely in the tenocytes of tendons...
  49. ncbi request reprint Vascular NK-1 receptor occurrence in normal and chronic painful Achilles and patellar tendons: studies on chemically unfixed as well as fixed specimens
    Sture Forsgren
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, SE 901 87 Umea, Sweden
    Regul Pept 126:173-81. 2005
    ....
  50. ncbi request reprint Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis
    Patrik Danielson
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, SE 901 87 Umea, Sweden
    Microsc Res Tech 69:808-19. 2006
    ..Thus, in conclusion, there appears to be an upregulation of the cholinergic system, and an occurrence of autocrine/paracrine effects in this system, in the tendinosis patellar tendon...
  51. ncbi request reprint Superior short-term results with eccentric calf muscle training compared to concentric training in a randomized prospective multicenter study on patients with chronic Achilles tendinosis
    N Mafi
    Department of Surgical and Perioperative Science, , Sweden
    Knee Surg Sports Traumatol Arthrosc 9:42-7. 2001
    ....
  52. ncbi request reprint Effects on neovascularisation behind the good results with eccentric training in chronic mid-portion Achilles tendinosis?
    Lars Ohberg
    Department of Diagnostic Radiology, University of Umea, 901 85 Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 12:465-70. 2004
    ..Action on the area with neovessels during the eccentric training regimen might possibly be responsible for the good clinical results...
  53. ncbi request reprint Shoulder pain -- a common problem in world-class badminton players
    Martin Fahlström
    Department of Community Medicine and Rehabilitation, Rehabilitation Medicine, Umea University, Umea, Sweden
    Scand J Med Sci Sports 16:168-73. 2006
    ..The study showed that shoulder pain is a common and significant problem in world-class badminton players, and the consequences are most likely of importance for their training and playing capacity...
  54. pmc Neovascularisation and pain in jumper's knee: a prospective clinical and sonographic study in elite junior volleyball players
    K Gisslén
    Department of Surgical and Perioperative Science, Sports Medicine, University of Umea, Umea, Sweden
    Br J Sports Med 39:423-8; discussion 423-8. 2005
    ..The nature of tendon neovascularisation associated with pain over time has not been studied...
  55. pmc Superior results with eccentric compared to concentric quadriceps training in patients with jumper's knee: a prospective randomised study
    P Jonsson
    Department of Surgical and Perioperative Science, Sports Medicine, Centre for Musculoskeletal Research, National Institute for Working Life, University of Umea, 901 87 Umea, Sweden
    Br J Sports Med 39:847-50. 2005
    ..A recent study reported promising clinical results using eccentric quadriceps training on a decline board to treat jumper's knee (patellar tendinosis)...
  56. doi request reprint Ultrasound and Doppler findings in the Achilles tendon among middle-aged recreational floor-ball players in direct relation to a match
    M Fahlström
    Department of Surgical and Perioperative Sciences, Umea University, Sweden
    Br J Sports Med 44:140-3. 2010
    ..In this study, structure, blood flow and thickness in the Achilles tendon related to tendon-loading activity were investigated...
  57. pmc Eccentric training in patients with chronic Achilles tendinosis: normalised tendon structure and decreased thickness at follow up
    L Ohberg
    Department of Radiation Sciences, Diagnostic Radiology, Umea University, Umea
    Br J Sports Med 38:8-11; discussion 11. 2004
    ..To prospectively investigate tendon thickness and tendon structure by ultrasonography in patients treated with eccentric calf muscle training for painful chronic Achilles tendinosis located at the 2-6 cm level in the tendon...
  58. doi request reprint New regimen for eccentric calf-muscle training in patients with chronic insertional Achilles tendinopathy: results of a pilot study
    P Jonsson
    Department of Surgical and Perioperative Sciences, Sports Medicine, Umea University, S 901 87 Umea, Sweden
    Br J Sports Med 42:746-9. 2008
    ..However, only 32% of patients with insertional Achilles tendinopathy had good clinical results with that type of eccentric training regimen...
  59. pmc Increased expression of cannabinoid CB₁ receptors in Achilles tendinosis
    Emmelie Björklund
    Pharmacology Unit, Department of Pharmacology and Clinical Neuroscience, Umea University, Umea, Sweden
    PLoS ONE 6:e24731. 2011
    ..Here we investigate the expression of the cannabinoid receptor 1 (CB₁) in human Achilles tendons from healthy volunteers and from patients with Achilles tendinosis...
  60. doi request reprint New insight into the non-neuronal cholinergic system via studies on chronically painful tendons and inflammatory situations
    Sture Forsgren
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, SE 901 87 Umea, Sweden
    Life Sci 84:865-70. 2009
    ..Additionally, the production of ACh in local cells in the tissues represents an important extra supply of the transmitter. ACh effects can be obtained whether or not there is a cholinergic innervation in the tissue...
  61. pmc Normal clinical and ultrasound findings indicate a low risk to sustain jumper's knee patellar tendinopathy: a longitudinal study on Swedish elite junior volleyball players
    Karl Gisslén
    Department of Surgical and Perioperative Science, Sports Medicine, Umea University, Umea, Sweden
    Br J Sports Med 41:253-8. 2007
    ..Jumper's knee patellar tendinopathy is well known to be a common and difficult injury in volleyball. Knowledge about its aetiology and pathogenesis is sparse...
  62. ncbi request reprint Periosteal transplantation to the rabbit patella
    Lisbeth Brax Olofsson
    Department of Surgical and Perioperative Sciences, Orthopedics, Umea University, 90185, Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 15:560-3. 2007
    ..In the other five animals, fibrocartilage was the predominant tissue. In contrast to previous experimental studies using a rabbit model, we did not achieve hyaline cartilage resurfacing...
  63. pmc Novel information on the non-neuronal cholinergic system in orthopedics provides new possible treatment strategies for inflammatory and degenerative diseases
    Sture Forsgren
    Dept of Integrative Medical Biology, Anatomy, Umea University, Umea, Sweden
    Orthop Rev (Pavia) 1:e11. 2009
    ..The conditions discussed are painful and degenerative tendon disease (tendinopathy/tendinosis), rheumatoid arthritis, and osteoarthritis...
  64. pmc A treatment algorithm for managing Achilles tendinopathy: new treatment options
    Håkan Alfredson
    Sports Medicine Unit, Department of Surgical and Perioperative Science, Umea University, Umea, Sweden
    Br J Sports Med 41:211-6. 2007
    ..If conservative treatment is not successful, then surgery relieves pain in the majority of cases. Directing a patient through the algorithm presented here will maximise positive treatment outcomes...
  65. doi request reprint Pain relief after intratendinous injections in patients with tennis elbow: results of a randomised study
    E Zeisig
    Sports Medicine Unit, Department of Surgical and Perioperative Science, Umea University, 901 87 Umea, Sweden
    Br J Sports Med 42:267-71. 2008
    ..Tennis elbow" is a difficult condition to treat. Ultrasonography (US) and colour Doppler (CD) guided injections with polidocanol targeting the area with increased blood flow in the extensor origin have shown promising clinical results...
  66. doi request reprint High-impact loading on the skeleton is associated with a decrease in glucose levels in young men
    Peder Wiklund
    Department of Surgical and Perioperative Sciences, Umea University, Sweden
    Clin Endocrinol (Oxf) 77:823-7. 2012
    ....
  67. ncbi request reprint Studies on the importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man
    Patrik Danielson
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, Umea, Sweden
    Microsc Res Tech 70:310-24. 2007
    ..Furthermore, the results imply that a possible source of catecholamine production might be the tenocytes themselves..
  68. ncbi request reprint Good clinical results but persisting side-to-side differences in calf muscle strength after surgical treatment of chronic Achilles tendinosis: a 5-year follow-up
    L Ohberg
    Department of Surgical and Perioperative Science, National Institute for Working Life, , Sweden
    Scand J Med Sci Sports 11:207-12. 2001
    ..However, the percentage side-to-side difference is relatively low, and might not have any clinical relevance...
  69. ncbi request reprint Neovascularisation in Achilles tendons with painful tendinosis but not in normal tendons: an ultrasonographic investigation
    L Ohberg
    Department of Surgical and Perioperative Science, , Sweden
    Knee Surg Sports Traumatol Arthrosc 9:233-8. 2001
    ..The neovascularisation found in this investigation might have implications on the pathogenesis of chronic Achilles tendinosis...
  70. doi request reprint Immunohistochemical evidence of local production of catecholamines in cells of the muscle origins at the lateral and medial humeral epicondyles: of importance for the development of tennis and golfer's elbow?
    E Zeisig
    Department of Surgical andPerioperative Sciences, Sportsmedicine, Medical Faculty, Umea University, Umea, Sweden
    Br J Sports Med 43:269-75. 2009
    ..However, it is not known whether there is local production of catecholamines and/or acetylcholine in this tissue, which is the case in patellar and Achilles tendinopathies...
  71. ncbi request reprint Balance board training: prevention of traumatic injuries of the lower extremities in female soccer players? A prospective randomized intervention study
    K Söderman
    Department of Surgical and Perioperative Science, Umea University, 90187 Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 8:356-63. 2000
    ....
  72. ncbi request reprint Injuries in adolescent female players in European football: a prospective study over one outdoor soccer season
    K Söderman
    Department of Surgical and Perioperative Science, Sports Medicine Unit, Umea University, Sweden
    Scand J Med Sci Sports 11:299-304. 2001
    ..Most of the injuries were of moderate severity (52%), while 34% were minor and 14% were major. Most of the major injuries were traumatic such as knee ligament injuries and ankle sprains...
  73. ncbi request reprint Risk factors for leg injuries in female soccer players: a prospective investigation during one out-door season
    K Söderman
    Department of Surgical and Perioperative Sciences, Sports Medicine Unit, Umea University, 90187 Umea, Sweden
    Knee Surg Sports Traumatol Arthrosc 9:313-21. 2001
    ..All five players who suffered an anterior cruciate ligament injury during the study period had a lower hamstring-to-quadriceps ratio during concentric action on the injured side than on their noninjured side...
  74. ncbi request reprint Anterior cruciate ligament injuries in young females playing soccer at senior levels
    K Söderman
    Department of Surgical and Perioperative Sciences, Sports Medicine Unit, Umea University, Stockholm, Sweden
    Scand J Med Sci Sports 12:65-8. 2002
    ..Therefore, we suggest that female soccer players under the age of 16 years should be allowed to participate only in practice sessions but not games at a senior level...