Johan D Soderholm

Summary

Country: Sweden

Publications

  1. pmc Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease
    J D Soderholm
    Department of Surgery and Clinical Research Centre, University Hospital, Linkoping, Sweden
    Gut 50:307-13. 2002
  2. ncbi request reprint The role of microbiota and probiotics in stress-induced gastro-intestinal damage
    Femke Lutgendorff
    Department of Clinical and Experimental Medicine, Division of Surgery, University Hospital, SE 581 85 Linkoping, Sweden
    Curr Mol Med 8:282-98. 2008
  3. pmc Stress-related changes in oesophageal permeability: filling the gaps of GORD?
    Johan D Soderholm
    Department of Clinical and Experimental Medicine, Linkoping University, Faculty of Health Sciences, SE 581 85 Linkoping, Sweden
    Gut 56:1177-80. 2007
  4. pmc Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor alpha
    J D Soderholm
    Department of Surgery, University Hospital, SE 581 85 Linkoping, Sweden
    Gut 53:1817-24. 2004
  5. ncbi request reprint Long-term endoscopic remission of crohn disease after autologous stem cell transplantation for acute myeloid leukaemia
    J D Soderholm
    Dept of Surgery, University Hospital, Linkoping, Sweden
    Scand J Gastroenterol 37:613-6. 2002
  6. pmc Increased antigen and bacterial uptake in follicle associated epithelium induced by chronic psychological stress in rats
    A K Velin
    Department of Biomedicine and Surgery, Division of Surgery, Clinical Research Centre, Faculty of Health Sciences, University Hospital, Linkoping, Sweden
    Gut 53:494-500. 2004
  7. ncbi request reprint Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum
    Asa V Keita
    Department of Biomedicine and Surgery, Division of Surgery, University Hospital, Linkoping, Sweden
    Lab Invest 86:504-16. 2006
  8. doi request reprint Probiotics enhance pancreatic glutathione biosynthesis and reduce oxidative stress in experimental acute pancreatitis
    Femke Lutgendorff
    Dept of Clinical and Experimental Medicine, Division of Surgery, Univ Hospital, 581 85 Linkoping, Sweden
    Am J Physiol Gastrointest Liver Physiol 295:G1111-21. 2008
  9. pmc CD83+CCR7- dendritic cells accumulate in the subepithelial dome and internalize translocated Escherichia coli HB101 in the Peyer's patches of ileal Crohn's disease
    Sa ad Y Salim
    Divisions of Surgery, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Am J Pathol 174:82-90. 2009
  10. ncbi request reprint Long-term morpho-functional development of Helicobacter pylori-induced gastritis in Mongolian gerbils
    Yi Qian Sun
    Department of Biomedicine and Surgery, University of Linkoping, and Pathology Research Department, Ryhov Hospital, Fonköping, Sweden
    Scand J Gastroenterol 40:1157-67. 2005

Collaborators

Detail Information

Publications23

  1. pmc Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease
    J D Soderholm
    Department of Surgery and Clinical Research Centre, University Hospital, Linkoping, Sweden
    Gut 50:307-13. 2002
    ..The luminal contents are important for development of neoinflammation following resection. Regulation of tight junctions by luminal factors has not previously been studied in Crohn's disease...
  2. ncbi request reprint The role of microbiota and probiotics in stress-induced gastro-intestinal damage
    Femke Lutgendorff
    Department of Clinical and Experimental Medicine, Division of Surgery, University Hospital, SE 581 85 Linkoping, Sweden
    Curr Mol Med 8:282-98. 2008
    ..We are however far from being able to choose the precise combination of strains or bacterial components for each clinical setting...
  3. pmc Stress-related changes in oesophageal permeability: filling the gaps of GORD?
    Johan D Soderholm
    Department of Clinical and Experimental Medicine, Linkoping University, Faculty of Health Sciences, SE 581 85 Linkoping, Sweden
    Gut 56:1177-80. 2007
    ..Recent data demonstrating that psychological stress may induce a permeability defect in stratified epithelia, including the oesophagus, shed new light on the pathophysiological events leading to heartburn and GORD...
  4. pmc Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor alpha
    J D Soderholm
    Department of Surgery, University Hospital, SE 581 85 Linkoping, Sweden
    Gut 53:1817-24. 2004
    ..Our aims were to study if this barrier defect (a) involves endocytotic uptake of antigens and (b) is related to low grade inflammation not detectable by histology...
  5. ncbi request reprint Long-term endoscopic remission of crohn disease after autologous stem cell transplantation for acute myeloid leukaemia
    J D Soderholm
    Dept of Surgery, University Hospital, Linkoping, Sweden
    Scand J Gastroenterol 37:613-6. 2002
    ..This has pathophysiological as well as therapeutic implications...
  6. pmc Increased antigen and bacterial uptake in follicle associated epithelium induced by chronic psychological stress in rats
    A K Velin
    Department of Biomedicine and Surgery, Division of Surgery, Clinical Research Centre, Faculty of Health Sciences, University Hospital, Linkoping, Sweden
    Gut 53:494-500. 2004
    ..Chronic stress affects the course of inflammatory bowel disease and experimental colitis, and may also initiate intestinal inflammation in rats...
  7. ncbi request reprint Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum
    Asa V Keita
    Department of Biomedicine and Surgery, Division of Surgery, University Hospital, Linkoping, Sweden
    Lab Invest 86:504-16. 2006
    ..We show for the first time that FAE of human ileum is functionally distinct from regular VE, rendering the FAE more prone to bacterial-epithelial cell interactions and delivery of antigens to the mucosal immune system...
  8. doi request reprint Probiotics enhance pancreatic glutathione biosynthesis and reduce oxidative stress in experimental acute pancreatitis
    Femke Lutgendorff
    Dept of Clinical and Experimental Medicine, Division of Surgery, Univ Hospital, 581 85 Linkoping, Sweden
    Am J Physiol Gastrointest Liver Physiol 295:G1111-21. 2008
    ..Probiotics enhanced the biosynthesis of glutathione, which may have reduced activation of inflammation and acinar cell injury and ameliorated experimental AP, via a reduction in oxidative stress...
  9. pmc CD83+CCR7- dendritic cells accumulate in the subepithelial dome and internalize translocated Escherichia coli HB101 in the Peyer's patches of ileal Crohn's disease
    Sa ad Y Salim
    Divisions of Surgery, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Am J Pathol 174:82-90. 2009
    ..In conclusion, nonmigrating dendritic cells that accumulate in the subepithelial dome and internalize nonpathogenic bacteria may be important for the onset and perpetuation of mucosal inflammation in Crohn's disease...
  10. ncbi request reprint Long-term morpho-functional development of Helicobacter pylori-induced gastritis in Mongolian gerbils
    Yi Qian Sun
    Department of Biomedicine and Surgery, University of Linkoping, and Pathology Research Department, Ryhov Hospital, Fonköping, Sweden
    Scand J Gastroenterol 40:1157-67. 2005
    ..The aim of this study was to investigate the long-term development of H. pylori-induced gastritis in Mongolian gerbils in terms of morphology, gastrin secretion, epithelial proliferation and gene expression of pro-inflammatory cytokines...
  11. pmc Probiotics prevent intestinal barrier dysfunction in acute pancreatitis in rats via induction of ileal mucosal glutathione biosynthesis
    Femke Lutgendorff
    Department of Clinical and Experimental Medicine, Division of Surgery, Linkoping University, Linkoping, Sweden
    PLoS ONE 4:e4512. 2009
    ..During acute pancreatitis (AP), oxidative stress contributes to intestinal barrier failure. We studied actions of multispecies probiotics on barrier dysfunction and oxidative stress in experimental AP...
  12. ncbi request reprint Effects of chronic stress on the immune response to oral human serum albumin-conjugated starch microparticles in rats
    Asa V Keita
    Department of Biomedicine and Surgery, Division of Surgery, Faculty of Health Sciences, Linkoping University, Sweden
    J Neuroimmunol 183:33-42. 2007
    ..We conclude that chronic stress affects the cell-mediated immune response after oral immunization, which may have implications for the understanding of allergic and autoimmune diseases and development of oral vaccines...
  13. doi request reprint Corticotropin-releasing hormone and mast cells in the regulation of mucosal barrier function in the human colon
    Conny Wallon
    Department of Clinical and Experimental Medicine, Division of Surgery, Linkoping University, Linkoping, Sweden
    Ann N Y Acad Sci 1165:206-10. 2009
    ..Since increased uptake of antigenic molecules is associated with mucosal inflammation, our findings may have implications for understanding stress-related intestinal disorders...
  14. ncbi request reprint Dihydroxy bile acids increase mucosal permeability and bacterial uptake in human colon biopsies
    Andreas Münch
    Department of Gastroenterology, UHL, Linkoping, Sweden
    Scand J Gastroenterol 42:1167-74. 2007
    ..The aim of this study was to investigate the influence of microM concentrations of dihydroxy bile acids on permeability and bacterial uptake in the normal human colon...
  15. ncbi request reprint Peyer's patches and M cells as potential sites of the inflammatory onset in Crohn's disease
    Elisabet Gullberg
    Colorectal Surgery Unit, Department of Surgery, University Hospital, SE 581 85 Linkoping, Sweden
    Ann N Y Acad Sci 1072:218-32. 2006
    ....
  16. doi request reprint Barrier dysfunction and bacterial uptake in the follicle-associated epithelium of ileal Crohn's disease
    Asa V Keita
    Department of Clinical and Experimental Medicine, Division of Surgery, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Ann N Y Acad Sci 1258:125-34. 2012
    ..This short review will discuss barrier dysfunction and bacteria in the context of ileal Crohn's disease, and how the FAE might be the site of initial inflammation...
  17. ncbi request reprint Endoscopic biopsies in Ussing chambers evaluated for studies of macromolecular permeability in the human colon
    Conny Wallon
    Clinical Research Centre, University of Linkoping, Sweden
    Scand J Gastroenterol 40:586-95. 2005
    ..Endoscopic biopsies in Ussing chambers have been introduced as a means of studying secretion and transepithelial permeability, but have not been evaluated for studies of protein antigen uptake in human intestine...
  18. doi request reprint Eosinophils express muscarinic receptors and corticotropin-releasing factor to disrupt the mucosal barrier in ulcerative colitis
    Conny Wallon
    Department of Clinical and Experimental Medicine, Division of Surgery, Linkoping University, Sweden
    Gastroenterology 140:1597-607. 2011
    ..Because eosinophils are often increased in colon tissues of patients with UC, we assessed interactions among mast cells, CRF, and eosinophils in the mucosal barrier of these patients...
  19. ncbi request reprint Atrophic gastritis is associated with increased sucrose permeability related to chronic inflammation
    Camilla Sjöstedt Zsigmond
    Department of Biomedicine and Surgery, University Hospital of Linkoping, Sweden
    Digestion 72:201-6. 2005
    ..One contributing factor could be impaired function of the gastric mucosal barrier. The aim of this study was to investigate if there are changes in gastric mucosal permeability to sucrose in atrophic gastritis...
  20. doi request reprint Surgery in ulcerative colitis: indication and timing
    Peter Andersson
    Department of Surgery, Linkoping University Hospital, SE 581 85 Linkoping, Sweden
    Dig Dis 27:335-40. 2009
    ..Therefore, close interactions between gastroenterologists and colorectal surgeons are mandatory for optimal patient outcome...
  21. doi request reprint Importance of disrupted intestinal barrier in inflammatory bowel diseases
    Sa ad Y Salim
    Department of Clinical and Experimental Medicine, Division of Surgery and Clinical Oncology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Inflamm Bowel Dis 17:362-81. 2011
    ..quot; Here we give an overview of the key players of the intestinal mucosal barrier and review the current literature from studies in humans and human systems on mechanisms underlying mucosal barrier dysfunction in IBD...
  22. doi request reprint Mast cells and mastocytosis
    Johan D Soderholm
    Colorectal Surgery Unit, Department of Surgery, University Hospital, Linkoping, Sweden
    Dig Dis 27:129-36. 2009
    ..We need to learn how to balance the response of these volatile cells to be able to benefit from their versatility...
  23. ncbi request reprint Long-standing gastric mucosal barrier dysfunction in Helicobacter pylori-induced gastritis in mongolian gerbils
    Yi Qian Sun
    Division of Surgery, Department of Biomedicine and Surgery, Faculty of Health Sciences, University of Linkoping, Sweden
    Helicobacter 9:217-27. 2004
    ..An impaired gastric mucosal barrier could be involved in these processes. Our aim was to investigate gastric barrier function in H. pylori-induced gastritis...