I Skoog

Summary

Country: Sweden

Publications

  1. ncbi Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 7:812-26. 2008
  2. ncbi Head size may modify the impact of white matter lesions on dementia
    Ingmar Skoog
    Neuropsychiatric Epidemiology Unit, Section for Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Neurobiol Aging 33:1186-93. 2012
  3. ncbi Highs and lows of blood pressure:a cause of Alzheimer's disease?
    Ingmar Skoog
    Department of Psychiatry, Sahlgrenska University Hospital, S 413 45, Goteborg, Sweden
    Lancet Neurol 2:334. 2003
  4. ncbi Magnetic-resonance imaging to assess Alzheimer's disease
    Ingmar Skoog
    Institute of Clinical Neurosciences, Section of Psychiatry, Neuropsychiatric Epidemiology Unit, Sahlgrenska University Hospital, , Sweden
    Lancet 359:1538-9. 2002
  5. ncbi Hypertension and cognition
    Ingmar Skoog
    Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgrenska Hospital, Goteborg University, Goteborg, Sweden
    Int Psychogeriatr 15:139-46. 2003
  6. ncbi Effect of baseline cognitive function and antihypertensive treatment on cognitive and cardiovascular outcomes: Study on COgnition and Prognosis in the Elderly (SCOPE)
    Ingmar Skoog
    Institute of Clinical Neurosciences, Neuropsychiatric Epidemiology Unit, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Am J Hypertens 18:1052-9. 2005
  7. ncbi Hypertension and related factors in the etiology of Alzheimer's disease
    Ingmar Skoog
    Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgrenska University Hospital, Goteborg University, SE 413 45 Goteborg, Sweden
    Ann N Y Acad Sci 977:29-36. 2002
  8. ncbi Subcortical vascular dementia
    Ingmar Skoog
    Institute of Clinical Neurosciences, Neuroepidemiology Unit, , , Sweden
    Clin Neuropsychol 18:4-5. 2004
  9. ncbi Evolutionary rather than revolutionary progress in dementia
    Ingmar Skoog
    Institute of Clinical Neurosciences, Unit of Neuropsychiatric Epidemiology, , , Sweden
    Lancet Neurol 3:17. 2004
  10. ncbi Psychiatric epidemiology of old age: the H70 study--the NAPE lecture 2003
    I Skoog
    Department of Psychiatry, Sahlgrenska University Hospital, Goteborg, Sweden
    Acta Psychiatr Scand 109:4-18. 2004

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 7:812-26. 2008
    ..Dementia costs in developing countries are estimated to be US$73 billion yearly, but care demands social protection, which seems scarce in these regions...
  2. ncbi Head size may modify the impact of white matter lesions on dementia
    Ingmar Skoog
    Neuropsychiatric Epidemiology Unit, Section for Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Neurobiol Aging 33:1186-93. 2012
    ..TICV did not modify the odds of dementia in those with the apolipoprotein e4 phenotype. Our results suggest that the impact of brain pathology on the risk of dementia is modified by premorbid brain size...
  3. ncbi Highs and lows of blood pressure:a cause of Alzheimer's disease?
    Ingmar Skoog
    Department of Psychiatry, Sahlgrenska University Hospital, S 413 45, Goteborg, Sweden
    Lancet Neurol 2:334. 2003
  4. ncbi Magnetic-resonance imaging to assess Alzheimer's disease
    Ingmar Skoog
    Institute of Clinical Neurosciences, Section of Psychiatry, Neuropsychiatric Epidemiology Unit, Sahlgrenska University Hospital, , Sweden
    Lancet 359:1538-9. 2002
  5. ncbi Hypertension and cognition
    Ingmar Skoog
    Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgrenska Hospital, Goteborg University, Goteborg, Sweden
    Int Psychogeriatr 15:139-46. 2003
    ..Even if hypertension results only in a moderately increased risk of AD, or overall dementia, better treatment of hypertension may have an immense effect on the total number of individuals with dementia...
  6. ncbi Effect of baseline cognitive function and antihypertensive treatment on cognitive and cardiovascular outcomes: Study on COgnition and Prognosis in the Elderly (SCOPE)
    Ingmar Skoog
    Institute of Clinical Neurosciences, Neuropsychiatric Epidemiology Unit, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Am J Hypertens 18:1052-9. 2005
    ..We examined whether cognitive function at baseline affected cognitive and cardiovascular outcomes in the Study on COgnition and Prognosis in the Elderly (SCOPE), a blood pressure (BP)-lowering intervention trial...
  7. ncbi Hypertension and related factors in the etiology of Alzheimer's disease
    Ingmar Skoog
    Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgrenska University Hospital, Goteborg University, SE 413 45 Goteborg, Sweden
    Ann N Y Acad Sci 977:29-36. 2002
    ..This review will examine the evidence for this association and possible pathways between hypertension, Alzheimer encephalopathy, and clinical dementia...
  8. ncbi Subcortical vascular dementia
    Ingmar Skoog
    Institute of Clinical Neurosciences, Neuroepidemiology Unit, , , Sweden
    Clin Neuropsychol 18:4-5. 2004
  9. ncbi Evolutionary rather than revolutionary progress in dementia
    Ingmar Skoog
    Institute of Clinical Neurosciences, Unit of Neuropsychiatric Epidemiology, , , Sweden
    Lancet Neurol 3:17. 2004
  10. ncbi Psychiatric epidemiology of old age: the H70 study--the NAPE lecture 2003
    I Skoog
    Department of Psychiatry, Sahlgrenska University Hospital, Goteborg, Sweden
    Acta Psychiatr Scand 109:4-18. 2004
    ..To describe methodological issues and possibilities in the epidemiology of old age psychiatry using data from the H70 study in Göteborg, Sweden...
  11. ncbi Hypertension, hypertension-clustering factors and Alzheimer's disease
    Ingmar Skoog
    Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgrenska Hospital, Goteborg University, Goteborg, Sweden
    Neurol Res 25:675-80. 2003
    ..Even if hypertension only results in a moderately increased risk of AD, or overall dementia, better treatment of hypertension may have an immense effect on the total numbr of demented individuals...
  12. ncbi Update on hypertension and Alzheimer's disease
    Ingmar Skoog
    Institute of Neuroscience and Physiology, Section of Psychiatry, Unite of Neuropsychiatric Epidemiology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Neurol Res 28:605-11. 2006
    ..Even though hypertension only results in a moderately increased risk of AD, or overall dementia, better treatment of hypertension may have an immense effect on the total number of demented individuals...
  13. ncbi Psychiatric disorders in the elderly
    Ingmar Skoog
    Institute of Neuroscience and Physiology, Section for Psychiatry Section, Unit of Neuropsychiatric Epidemiology, University of Gothenburg, Sweden
    Can J Psychiatry 56:387-97. 2011
    ..Psychiatric disorders, common among the elderly, have consequences that include social deprivation, poor quality of life, cognitive decline, disability, increased risk for somatic disorders, suicide, and increased nonsuicidal mortality...
  14. ncbi Secular changes in cognitive predictors of dementia and mortality in 70-year-olds
    S Sacuiu
    Department of Psychiatry and Neurochemistry, Unit of Psychiatric Epidemiology, University of Gothenburg and Sahlgrenska University Hospital, Institute of Neuroscience and Physiology, Wallinsgatan 6, 431 41 Mölndal, Sweden
    Neurology 75:779-85. 2010
    ..Successive elderly birth cohorts improved in cognitive performance during the 20th century. It is not clear whether this influences cognitive predictors of dementia and mortality...
  15. ncbi A population-based study on brain atrophy and motor performance in elderly women
    X Guo
    Department of Geriatric Medicine, Vasa Hospital, Goteborg University, Sweden
    J Gerontol A Biol Sci Med Sci 56:M633-7. 2001
    ..The relationship between brain atrophy and motor changes has not been frequently reported. This study investigates this relationship...
  16. ncbi A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia
    I Skoog
    Department of Psychiatry, Sahlgrenska University Hospital, Goteborg, Sweden
    Neurology 50:966-71. 1998
    ..6 +/- 2.1; p = 0.029) than other individuals. A relative BBB dysfunction is associated with both AD and VAD among very elderly individuals. This finding is possibly found early in the disease before the onset of clinical dementia...
  17. ncbi Suicidal feelings in a population sample of nondemented 85-year-olds
    I Skoog
    Department of Psychiatry, Sahlgrenska Hospital, Goteborg University, Sweden
    Am J Psychiatry 153:1015-20. 1996
    ..The authors studied the 1-month frequency of suicidal feelings among very old people...
  18. ncbi The prognosis and incidence of social phobia in an elderly population. A 5-year follow-up
    B Karlsson
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
    Acta Psychiatr Scand 122:4-10. 2010
    ..To examine the prognosis and incidence of social fears and phobia in an elderly population sample followed for 5 years...
  19. ncbi A population-based study on blood pressure and brain atrophy in 85-year-olds
    I Skoog
    From the Institute of Clinical Neuroscience, Department of Psychiatry, Sahlgrenska University Hospital, The Department of Geriatric Medicine, Vasa Hospital, Goteborg University, Sweden
    Hypertension 32:404-9. 1998
    ..21, P=0.043). Our findings suggest that age-related changes in brain structure may contribute to the decrease in blood pressure in the very elderly and that low blood pressure in dementia disorders is mainly a secondary phenomenon...
  20. ncbi The prevalence of depression in relation to cerebral atrophy and cognitive performance in 70- and 74-year-old women in Gothenburg. The Women's Health Study
    S Palsson
    Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Goteborg, Sweden
    Psychol Med 31:39-49. 2001
    ..Depression was diagnosed according to DSM-III-R. Previous depression was diagnosed by history and by information from previous examinations in this 24-year longitudinal study...
  21. ncbi The ACE Insertion Deletion polymorphism relates to dementia by metabolic phenotype, APOEepsilon4, and age of dementia onset
    D R Gustafson
    Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Sweden
    Neurobiol Aging 31:910-6. 2010
    ..Variations among reports on the relationship between the ACE ID polymorphism and dementia may be due to lack of consideration for gene-gene and gene-phenotype associations...
  22. ncbi Sleep disturbances in midlife unrelated to 32-year diabetes incidence: the prospective population study of women in Gothenburg
    Cecilia Bjorkelund
    Department of Primary Health Care, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Diabetes Care 28:2739-44. 2005
    ..To study the relation between diabetes incidence and sleep problems in a population-based sample of women followed for 32 years...
  23. ncbi A population study of apoE genotype at the age of 85: relation to dementia, cerebrovascular disease, and mortality
    I Skoog
    Department of Psychiatry, Sahlgrenska Hospital Institute of Clinical Neurosciences, Goteborg University, Sweden
    J Neurol Neurosurg Psychiatry 64:37-43. 1998
    ..To study the association of apoE genotypes with dementia and cerebrovascular disorders in a population based sample of 85 year old people...
  24. ncbi Seven-year survival rate after age 85 years: relation to Alzheimer disease and vascular dementia
    O Aevarsson
    Institute of Clinical Neuroscience, Department of Psychiatry, Sahlgrenska Hospital, Goteborg University, Sweden
    Arch Neurol 55:1226-32. 1998
    ..To investigate the survival rate in very elderly individuals in relation to Alzheimer disease, vascular dementia, and other mental and physical disorders...
  25. ncbi Depression, cerebral atrophy, cognitive performance and incidence of dementia. Population study of 85-year-olds
    S Palsson
    Department of Psychiatry, Sahlgrenska University Hospital, Goteborg, Sweden
    Br J Psychiatry 174:249-53. 1999
    ..Hospital-based studies suggest that depression in old age relates to organic brain changes...
  26. ncbi Prodromal cognitive signs of dementia in 85-year-olds using four sources of information
    S Sacuiu
    Psychiatry Section, Institute of Clinical Neuroscience, Sahlgrenska Academy, Goteborg University, Sweden
    Neurology 65:1894-900. 2005
    ..To evaluate the utility of assessing four cognitive domains obtained from four information sources to identify individuals at risk for developing dementia, Alzheimer disease (AD), and vascular dementia (VaD)...
  27. ncbi The relationship between cerebrospinal fluid biomarkers and depression in elderly women
    Pia Gudmundsson
    Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Am J Geriatr Psychiatry 15:832-8. 2007
    ..However, studies focusing on the relationship between these CSF biomarkers and geriatric depression are lacking...
  28. ncbi A population-based study on the influence of brain atrophy on 20-year survival after age 85
    P J Olesen
    Neuropsychiatric Epidemiology Unit, Wallinsgatan 6, 43141 Mölndal, Sweden
    Neurology 76:879-86. 2011
    ..To understand the biology behind increasing longevity, it is important to examine factors related to survival in this age group. The relationship between brain atrophy and survival after age 85 remains unclear...
  29. ncbi Health-related quality of life during treatment of elderly patients with hypertension: results from the Study on COgnition and Prognosis in the Elderly (SCOPE)
    A degl'Innocenti
    AstraZeneca R and D, Clinical Science, Molndal, Sweden
    J Hum Hypertens 18:239-45. 2004
    ..In conclusion, there should be no reason to withhold modern antihypertensive therapy in elderly patients due to concerns for a negative effect on HRQL...
  30. ncbi Adiposity indicators and dementia over 32 years in Sweden
    D R Gustafson
    Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Sahlgrenska Academy, University of Gothenburg, Sweden
    Neurology 73:1559-66. 2009
    ..Late-life decrease in body mass index (BMI) or body weight within several years of a dementia diagnosis has also been reported. Differences in study designs and analyses may provide different pictures of this relationship...
  31. ncbi The incidence of first-onset psychotic symptoms and paranoid ideation in a representative population sample followed from age 70-90 years. Relation to mortality and later development of dementia
    S Ostling
    The Sahlgrenska Academy at Goteborg University, Institute of Clinical Neuroscience and Physiology, Psychiatry Section, Unit of Epidemiology, Sahlgrenska University Hospital, Goteborg, Sweden
    Int J Geriatr Psychiatry 22:520-8. 2007
    ..Limited data are available on the incidence of psychotic symptoms in the elderly...
  32. ncbi Prevalence of social phobia in non-demented elderly from a swedish population study
    Björn Karlsson
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
    Am J Geriatr Psychiatry 17:127-35. 2009
    ....
  33. ncbi Onset of terminal decline in cognitive abilities in individuals without dementia
    V Thorvaldsson
    Department of Psychology, Goteborg University, Box 500, SE 405 30 Goteborg, Sweden
    Neurology 71:882-7. 2008
    ..To identify time of onset and rate of mortality-related change (terminal decline) in cognitive abilities in later life...
  34. ncbi Alcoholic beverages and incidence of dementia: 34-year follow-up of the prospective population study of women in Goteborg
    K Mehlig
    Department of Public Health and Community Medicine Primary Health Care, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Am J Epidemiol 167:684-91. 2008
    ..Because a protective effect was not seen for the other beverages, at least part of the association for wine may be explained by components other than ethanol...
  35. ncbi A longitudinal study on changes of movement performance and their relation to medical conditions in a female population followed from age 70 to 78
    Xinxin Guo
    Department of Geriatric Medicine, Goteborg University, Gibraltargatan 1C, 411 32 Goteborg, Sweden
    Arch Gerontol Geriatr 36:127-40. 2003
    ..Arthritis and dyspnea at baseline, and incident diseases during follow-up were related to this age-related decline of movement performance...
  36. ncbi Association of the RAGE G82S polymorphism with Alzheimer's disease
    Jonny Daborg
    Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 432, 405 30, Gothenburg, Sweden
    J Neural Transm 117:861-7. 2010
    ..4), and none of the AGER SNPs showed association with Abeta(42), T-tau, P-tau(181) or mini-mental state examination scores. The data speak for a weak, but significant effect of AGER on risk of AD...
  37. ncbi The incidence of first-onset depression in a population followed from the age of 70 to 85
    S P Pálsson
    Institute of Clinical Neuroscience, Department of Psychiatry, Sahlgrenska University Hospital, Goteborg University, Sweden
    Psychol Med 31:1159-68. 2001
    ..Due to the limited data available, it is not clear whether the incidence of first-onset depression varies with age in the elderly...
  38. ncbi Tau and Abeta42 in cerebrospinal fluid from healthy adults 21-93 years of age: establishment of reference values
    M Sjogren
    Institute of Clinical Neuroscience, Psychiatry Section, Goteborg University, SE 431 80 Molndal, Sweden
    Clin Chem 47:1776-81. 2001
    ..For the introduction of these assays in clinical practice, adequate reference values are of importance...
  39. ncbi The pattern of cognitive symptoms predicts time to dementia onset
    Simona Sacuiu
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Alzheimers Dement 5:199-206. 2009
    ..Our objective was to investigate whether different patterns of cognitive symptoms at ages 70, 75, and 79 years predict short-term (< or =5 years) and long-term (>5 years) dementia onset...
  40. ncbi Regional cerebral blood flow in normal individuals aged 40, 75 and 88 years studied by 99Tc(m)-d,l-HMPAO SPET
    A Larsson
    Section of Neurology, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Goteborg University, Sweden
    Nucl Med Commun 22:741-6. 2001
    ..The reduction in rCBF in the hippocampus rose from 0.14% between the ages of 40 and 75 years to 0.33% between the ages of 75 and 88 years. The mean rCBF in all 33 individuals showed no sex-related differences...
  41. ncbi The prevalence of frontal variant frontotemporal dementia and the frontal lobe syndrome in a population based sample of 85 year olds
    T B Gislason
    The Institute of Clinical Neuroscience, Department of Psychiatry, Sahlgrenska Hospital, Gothenburg, Sweden
    J Neurol Neurosurg Psychiatry 74:867-71. 2003
    ..Only a minority of those with fvFTD were detected by the DSM-III-R criteria for dementia. FLS was even more common, especially in those diagnosed with a dementia disorder...
  42. ncbi Burden of illness and suicide in elderly people: case-control study
    Margda Waern
    Section of Psychiatry, Institute of Clinical Neuroscience, Gothenburg University, Karolinska Institute, Stockholm, Sweden
    BMJ 324:1355. 2002
    ..To study the association between physical illness and suicide in elderly people...
  43. ncbi Body mass index and white matter lesions in elderly women. An 18-year longitudinal study
    D R Gustafson
    Department of Family and Community Medicine, Medical College of Wisconsin, USA
    Int Psychogeriatr 16:327-36. 2004
    ..We investigated the longitudinal relationship between body mass index (BMI), a major vascular risk factor, and white matter lesions (WMLs) in older women...
  44. ncbi A 24-year follow-up of body mass index and cerebral atrophy
    D Gustafson
    Department of Family and Community Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Neurology 63:1876-81. 2004
    ..To investigate the longitudinal relationship between body mass index (BMI), a major vascular risk factor, and cerebral atrophy, a marker of neurodegeneration, in a population-based sample of middle-aged women...
  45. ncbi Depressive disorders after 20 months in elderly stroke patients: a case-control study
    Thomas Linden
    The Institute of Neuroscience and Physiology, Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Stroke 38:1860-3. 2007
    ..We aimed to examine the risk of depression in elderly patients one and a half years after stroke and to compare the risk with a population-based control sample...
  46. ncbi Psychotic symptoms and paranoid ideation in a nondemented population-based sample of the very old
    Svante Ostling
    Goteborg University, Institute of Clinical Neuroscience, Psychiatry Section, Sahlgrenska University Hospital S, SE 413 45 Goteborg, Sweden
    Arch Gen Psychiatry 59:53-9. 2002
    ..Psychotic symptoms are reported to be uncommon in the elderly, and may be underrated in traditional epidemiological studies...
  47. ncbi Secular trends in self reported sexual activity and satisfaction in Swedish 70 year olds: cross sectional survey of four populations, 1971-2001
    Nils Beckman
    Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
    BMJ 337:a279. 2008
    ..To study secular trends in self reported sexual behaviour among 70 year olds...
  48. ncbi Midlife respiratory function related to white matter lesions and lacunar infarcts in late life: the Prospective Population Study of Women in Gothenburg, Sweden
    Xinxin Guo
    Neuropsychiatric Epidemiology Unit, Institute of Neurosciences and Physiology, Sahlgrenska Academy at Goteborg University, Sweden
    Stroke 37:1658-62. 2006
    ..We examined midlife and late-life respiratory function in relation to small-vessel disease on computed tomography (CT) in women followed for 26 years...
  49. ncbi Hearing loss and cortical atrophy in a population-based study on non-demented women
    Xinxin Guo
    Department of Psychiatry, Sahlgrenska University Hospital, , Sweden
    Age Ageing 37:333-6. 2008
  50. ncbi Five-year mortality in relation to dementia and cognitive function in 95-year-olds
    Anne Börjesson-Hanson
    Neuropsychiatric Epidemiology Unit, Psychiatry Section, Institute of Neuroscience and Physiology, Sahlgrenska Academy at Goteborg University, Sweden
    Neurology 69:2069-75. 2007
    ..Dementia is a known predictor of mortality, but most studies include small numbers of participants above age 90. The influence of dementia or cognition on mortality in this age group is therefore uncertain...
  51. ncbi Psychotic symptoms and paranoid ideation in a population-based sample of 95-year-olds
    Svante Ostling
    Sahlgrenska Academy at Goteborg University, Institute of Neuroscience and Physiology, Psychiatry, and Neurochemistry Section, Sahlgrenska University Hospital, Goteborg, Sweden
    Am J Geriatr Psychiatry 15:999-1004. 2007
    ..To examine the 1-year prevalence of psychotic symptoms and schizophrenia in nondemented 95-year-olds, and to examine the relation between psychotic symptoms and other psychiatric symptoms, sensory impairments, and cognitive functioning...
  52. ncbi Midlife respiratory function and Incidence of Alzheimer's disease: a 29-year longitudinal study in women
    Xinxin Guo
    Neuropsychiatric Epidemiology Unit, Institute of Clinical Neurosciences, Sahlgrenska Academy at Goteborg University, SE 413 45 Goteborg, Sweden
    Neurobiol Aging 28:343-50. 2007
    ..94), 0.71 (0.54-0.95) and 0.74 (0.56-0.98), respectively, after adjustment for potential confounders. These data reinforce the advantages of maintaining good respiratory function in midlife, even though causation cannot be established...
  53. ncbi Basal ganglia calcification and psychotic symptoms in the very old
    Svante Ostling
    The Sahlgrenska Academy at Goteborg University, Institute of Clinical Neuroscience, Psychiatry Section, Unit for Neuropsychiatric Epidemiology, Sahlgrenska University Hospital, Goteborg, Sweden
    Int J Geriatr Psychiatry 18:983-7. 2003
    ..Basal ganglia calcification (BGC) is associated with psychotic symptoms in young and middle-aged patient samples...
  54. ncbi Mental disorder in elderly suicides: a case-control study
    Margda Waern
    Section of Psychiatry, Institute of Clinical Neuroscience and Department of Social Medicine, , Sweden
    Am J Psychiatry 159:450-5. 2002
    ....
  55. ncbi Temporal lobe atrophy and white matter lesions are related to major depression over 5 years in the elderly
    Pernille J Olesen
    Neuropsychiatric Epidemiology Unit, Section for Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Neuropsychopharmacology 35:2638-45. 2010
    ..This may have implications for prevention, as both neurodegeneration and cerebrovascular disease have been related to preventable factors...
  56. ncbi Participation bias in longitudinal studies: experience from the Population Study of Women in Gothenburg, Sweden
    Lauren Lissner
    Department of Primary Health Care, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Scand J Prim Health Care 21:242-7. 2003
    ..To describe a cohort study of women receiving a series of comprehensive health examinations over 32 years...
  57. ncbi Cognitive impairment and dementia 20 months after stroke
    Thomas Linden
    Stroke Research Group, Department of Clinical Neuroscience, Sahlgrenska University Hospital, Goteborg, Sweden
    Neuroepidemiology 23:45-52. 2004
    ..Our aim was to quantify and compare dementia and cognitive impairments in elderly patients 1.5 years after stroke and a matched normal population...
  58. ncbi Is there a CSF biomarker profile related to depression in elderly women?
    Pia Gudmundsson
    Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Sahlgrenska Academy at University of Gothenburg, Sweden
    Psychiatry Res 176:174-8. 2010
    ..This contrasts with the well-characterized pattern of low Abeta42, higher CSF/serum albumin ratio, and higher NFL in Alzheimer's disease...
  59. ncbi Attempted suicide in the elderly: characteristics of suicide attempters 70 years and older and a general population comparison group
    Stefan Wiktorsson
    Department of Psychiatry and Neurochemistry, Neuropshychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Stockholm, Sweden
    Am J Geriatr Psychiatry 18:57-67. 2010
    ..To identify factors associated with attempted suicide in the elderly...
  60. ncbi Cerebrospinal fluid beta-amyloid 1-42 concentration may predict cognitive decline in older women
    Deborah R Gustafson
    The Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Neurol Neurosurg Psychiatry 78:461-4. 2007
    ..It is not known, however, whether these biomarkers may be risk indicators for cognitive decline in otherwise healthy older people...
  61. ncbi One-month prevalence of mental disorders in a population sample of 95-year olds
    Anne Börjesson-Hanson
    Department of Psychiatry and Neurochemistry, Neuropsychiatry Epidemiology Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Am J Geriatr Psychiatry 19:284-91. 2011
    ..To determine the 1-month prevalence of mental disorders among 95-year olds...
  62. ncbi Cognitive impairment after stroke - impact on activities of daily living and costs of care for elderly people. The Göteborg 70+ Stroke Study
    Lisbeth Claesson
    Sahlgrenska Academy at Goteborg University, Institute of Clinical Neuroscience, Stroke Research Group, Goteborg University, Goteborg, Sweden
    Cerebrovasc Dis 19:102-9. 2005
    ..We examined the impact of the cognitive impairments on the ability to perform activities of daily living (ADL) and utilization and costs of health care in a cohort of elderly stroke patients...
  63. ncbi The prevalence of dementia in 95 year olds
    Anne Börjesson-Hanson
    Neuropsychiatric Epidemiology Unit, Psychiatry Section, Institute of Clinical Neuroscience, Sahlgrenska Academy, Goteborg University, Sweden
    Neurology 63:2436-8. 2004
    ..ed) was higher in women (55%) than in men (37%) at age 95, and the proportion of mild dementia and vascular dementia was lower in 95 than in 85 year olds...
  64. ncbi Blood pressure components and changes in relation to white matter lesions: a 32-year prospective population study
    Xinxin Guo
    Institute of Neuroscience and Physiology, University of Gothenburg, Sweden
    Hypertension 54:57-62. 2009
    ..2 [1.4 to 3.4] for mean arterial pressure). Our findings suggest that lowering high diastolic blood pressure and preventing large increases in systolic and diastolic blood pressures may have a protective effect on white matter lesions...
  65. ncbi An 18-year follow-up of overweight and risk of Alzheimer disease
    Deborah Gustafson
    Department of Nutrition and Food Sciences, Utah State University, Logan, USA
    Arch Intern Med 163:1524-8. 2003
    ..Using body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters), we examined whether overweight is a risk factor for dementia and AD...
  66. ncbi A population-based study on phobic fears and DSM-IV specific phobia in 70-year olds
    Robert Sigström
    Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, University of Gothenburg, Molndal, Sweden
    J Anxiety Disord 25:148-53. 2011
    ..SP was related to lower global functioning. We conclude that specific phobia in the elderly should receive attention from health professionals as it is common and associated with a decrease in global functioning...
  67. ncbi Midlife psychological stress and risk of dementia: a 35-year longitudinal population study
    Lena Johansson
    Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at Gothenburg University, 43141 Mölndal, Sweden
    Brain 133:2217-24. 2010
    ..More studies are needed to confirm our findings and to study potential neurobiological mechanisms of these associations...
  68. ncbi Cognitive test performance in relation to psychotic symptoms and paranoid ideation in non-demented 85-year-olds
    S Ostling
    Sahlgrenska Academy at Goteborg University, Institute of Clinical Neuroscience, Sweden
    Psychol Med 34:443-50. 2004
    ..However, it is not clear whether this finding would be observed in general population samples of non-demented elderly, particularly after adjustment for potential confounding factors...
  69. ncbi Body mass index, other cardiovascular risk factors, and hospitalization for dementia
    Annika Rosengren
    Department of Medicine, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Arch Intern Med 165:321-6. 2005
    ..We investigated the longitudinal relationship between body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters) and risk of hospital discharge or death certificate diagnosis of dementia...
  70. ncbi Association of complement factor H Y402H gene polymorphism with Alzheimer's disease
    Madeleine Zetterberg
    Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Am J Med Genet B Neuropsychiatr Genet 147:720-6. 2008
    ..The CFH 1277C allele may predispose patients for co-morbidity in AD and AMD...
  71. ncbi Secular changes in personality: study on 75-year-olds examined in 1976-1977 and 2005-2006
    E Billstedt
    Neuropsychiatric Epidemiology, Institute of Neuroscience and Physiology, University of Gothenburg, Sweden
    Int J Geriatr Psychiatry 28:298-304. 2013
    ....
  72. ncbi The clinical implications of cognitive impairment in elderly patients with chronic heart failure
    I Ekman
    Institute of Nursing, Goteborg University, Sweden
    J Cardiovasc Nurs 16:47-55. 2001
    ..Cognitive dysfunction, which was related to the duration of heart failure, should be evaluated in the treatment of patients with chronic heart failure...
  73. ncbi Visual neglect and cognitive impairment in elderly patients late after stroke
    T Linden
    The Stroke Research Unit, Arvid Carlsson Institute, Institute of Clinical Neuroscience, Gothenburg University, Gothenburg, Sweden
    Acta Neurol Scand 111:163-8. 2005
    ..To investigate the prevalence of visual neglect and its relationship to cognitive impairment and dementia in elderly stroke patients 20 months after stroke...
  74. ncbi A review on blood pressure and ischaemic white matter lesions
    I Skoog
    Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgrenska Hospital, Goteborg University, Sweden
    Dement Geriatr Cogn Disord 9:13-9. 1998
    ..The association between WMLs and hypertension may thus be mediated through several different pathogenetic pathways...
  75. ncbi Mid-life adiposity factors relate to blood-brain barrier integrity in late life
    D R Gustafson
    Department of Psychiatry and Neurochemistry Neuropsychiatric Epidemiology Unit, Institute of Physiology and Neuroscience, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
    J Intern Med 262:643-50. 2007
    ..Adiposity factors included body mass index and blood levels of sex hormone binding globulin (SHBG) and leptin. Design. Retrospective analyses over 24 years within a longitudinal study...
  76. ncbi Cerebrospinal fluid beta-amyloid 42 is reduced before the onset of sporadic dementia: a population-based study in 85-year-olds
    I Skoog
    Institute of Clinical Neuroscience, Unit of Neuropsychiatric Epidemiology, , Sahlgrenska University Hospital, , Sweden
    Dement Geriatr Cogn Disord 15:169-76. 2003
    ....
  77. ncbi Homocysteine levels and lacunar brain infarcts in elderly women: the prospective population study of women in Gothenburg
    Dimitri Edin Zylberstein
    Section for Primary Health Care, Department of Public Health and Community Medicine, The Sahlgrenska Academy, Goteborg University, Gothenburg, Sweden
    J Am Geriatr Soc 56:1087-91. 2008
    ..To examine whether total serum homocysteine (tHcy) in a population-based sample of middle-aged women is an independent risk factor for presence of lacunar infarcts (LIs) 24 years later...
  78. ncbi Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract
    Malin von Otter
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Bla Straket 15, the Sahlgrenska Academy at University of Gothenburg, S 413 45 Gothenburg, Sweden
    Mech Ageing Dev 131:105-10. 2010
    ..009). Our findings do not support NFE2L2 or KEAP1 as susceptibility genes for AD or cataract. However, common variants of the NFE2L2 gene may affect disease progression, potentially altering clinically recognized disease onset...
  79. ncbi Changes in drug treatment in the elderly between 1971 and 2000
    B Lernfelt
    Department of Geriatric Medicine, University of Gothenburg, Vasa Hospital, 411 33 Gothenburg, Sweden
    Eur J Clin Pharmacol 59:637-44. 2003
    ..Important differences in the treatment patterns for different diseases were observed...
  80. ncbi Status of risk factors for vascular dementia
    I Skoog
    Institute of Clinical Neuroscience, Sahlgrenska Hospital, Goteborg University, Sweden
    Neuroepidemiology 17:2-9. 1998
    ..There is also a need for more studies on risk factors for VAD and risk factors for dementia in stroke samples, as well as studies on non-vascular risk factors for ischemic WMLs...
  81. ncbi Health and well-being among 70-year-old migrants living in Sweden--results from the H 70 gerontological and geriatric population studies in Göteborg
    E Silveira
    Department of Geriatric Medicine, Goteborg University, Vasa Hospital, Sweden
    Soc Psychiatry Psychiatr Epidemiol 37:13-22. 2002
    ..Comparative epidemiological studies in migrants in Sweden have shown increased prevalence of psychosocial morbidity in young adults, but there is paucity of information on health in people aged 65 years and over...
  82. ncbi The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial
    Hans Lithell
    Department of Public Health and Caring Sciences, Sections of Geriatrics Clinical Hypertension Research and Family Medicine, University of Uppsala, Uppsala, Sweden
    J Hypertens 21:875-86. 2003
    ..The prognostic benefits of blood pressure lowering treatment in elderly hypertensive patients were established more than a decade ago, but are less clear in those with mildly to moderately elevated blood pressure...
  83. ncbi Stroke prevention with the angiotensin II type 1-receptor blocker candesartan in elderly patients with isolated systolic hypertension: the Study on Cognition and Prognosis in the Elderly (SCOPE)
    Vasilios Papademetriou
    Hypertension and Cardiovascular Research, Veterans Administration Medical Center, Washington, DC 20422, USA
    J Am Coll Cardiol 44:1175-80. 2004
    ..The aim of this study was to test the hypothesis that the angiotensin II type 1 receptor blocker (ARB) candesartan can reduce the risk of stroke in elderly patients with isolated systolic hypertension (ISH)...
  84. ncbi Cognitive function and health-related quality of life in elderly patients with hypertension--baseline data from the study on cognition and prognosis in the elderly (SCOPE)
    Alessio degl'Innocenti
    AstroZeneca R and D, Molndal, Sweden
    Blood Press 11:157-65. 2002
    ..Age and the use of psychotropic drugs, but not gender and education level, influenced this relationship significantly...
  85. ncbi The Study on COgnition and Prognosis in the Elderly (SCOPE); outcomes in patients not receiving add-on therapy after randomization
    Hans Lithell
    Department of Public Health and Caring Sciences, Section of Geriatrics, University of Uppsala, Sweden
    J Hypertens 22:1605-12. 2004
    ..e. in patients that best reflect the original intention of a placebo-controlled trial...
  86. ncbi Silent and symptomatic infarcts on cranial computerized tomography in relation to dementia and mortality: a population-based study in 85-year-old subjects
    Martin Liebetrau
    Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany
    Stroke 35:1816-20. 2004
    ..Cerebrovascular disease as a cause of dementia may be underrated because of silent infarcts. It has to be elucidated whether treatment of risk factors for stroke may reduce the consequences of silent infarcts...
  87. ncbi Association between blood pressure levels over time and brain atrophy in the elderly
    Tom den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 sDR, Rotterdam, The Netherlands
    Neurobiol Aging 24:307-13. 2003
    ..53 units, 0.05-1.02). Both high and declining diastolic blood pressure levels are associated with more global brain atrophy on MRI...
  88. ncbi Stroke in 85-year-olds: prevalence, incidence, risk factors, and relation to mortality and dementia
    Martin Liebetrau
    Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany
    Stroke 34:2617-22. 2003
    ..In this age, it is important to use several sources of information to detect stroke because of the high number of demented. High blood pressure increases stroke risk also in the very old, which is important in relation to prevention...
  89. ncbi Lifetime risk of depression: restricted to a minority or waiting for most?
    Gavin Andrews
    Br J Psychiatry 187:495-6. 2005
  90. ncbi The Study on COgnition and Prognosis in the Elderly (SCOPE) - major CV events and stroke in subgroups of patients
    Peter Trenkwalder
    Department of Internal Medicine, Starnberg Hospital, Ludwig Maximilian University Munich, Osswaldstrasse 1, D 82319 Starnberg, Germany
    Blood Press 14:31-7. 2005
    ..However, the benefit was particularly pronounced in patients who entered the study with a previous stroke...
  91. ncbi A cross-national study of transitions in deficit counts in two birth cohorts: implications for modeling ageing
    Arnold Mitnitski
    Department of Medicine, Dalhousie University, Halifax, Canada
    Exp Gerontol 42:241-6. 2007
    ..The model suggests that all health transitions, including health improvement, worsening, and death, can be summarized in a unified stochastic model with a few interpretable parameters...
  92. ncbi Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70
    Kenneth Rockwood
    Geriatric Medicine Research Unit, Dalhousie University, 1431 5955 Veterans Memorial Lane, Halifax, Nova Scotia B3H 2E1, Canada
    J Am Geriatr Soc 54:975-9. 2006
    ..To measure relative fitness and frailty in older people without specific frailty instruments and to relate that measurement to long-term health outcomes...
  93. ncbi Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study
    Martin Steinberg
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Int J Geriatr Psychiatry 23:170-7. 2008
    ..Neuropsychiatric symptoms are nearly universal in dementia, yet little is known about their longitudinal course in the community...
  94. ncbi Antihypertensive medication use and incident Alzheimer disease: the Cache County Study
    Ara S Khachaturian
    Khachaturian and Associates Inc, Potomac, MD, USA
    Arch Neurol 63:686-92. 2006
    ..CONCLUSIONS: These data suggest that AH medications, and specifically potassium-sparing diuretics, are associated with reduced incidence of AD. Because the latter association is a new finding, it requires confirmation in further study...
  95. ncbi Three-year incidence of first-onset depressive syndrome in a population sample of older adults: the Cache County study
    Maria C Norton
    Department of Family, Consumer and Human Development, Utah State University, Logan, 84322, USA
    Am J Geriatr Psychiatry 14:237-45. 2006
    ....
  96. ncbi Diagnostic criteria influence dementia prevalence
    Johannes Wancata
    Medical University of Vienna, Department of Psychiatry, Vienna, Austria
    Am J Geriatr Psychiatry 15:1034-45. 2007
    ....
  97. ncbi Low serum potassium in mid life associated with decreased cerebrospinal fluid Abeta42 in late life
    Michelle M Mielke
    Center on Aging and Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Alzheimer Dis Assoc Disord 20:30-6. 2006
    ..Nonetheless, serum potassium is a modifiable risk factor and further examination of the potassium-dementia relationship is warranted...
  98. ncbi Advances in vascular cognitive impairment 2005
    Helena Chui
    The University of Southern California, Los Angeles, USA
    Stroke 37:323-5. 2006
  99. ncbi Antihypertensive treatment and dementia prevention
    Ingmar Skoog
    Lancet Neurol 7:664-5. 2008
  100. ncbi Relative fitness and frailty of elderly men and women in developed countries and their relationship with mortality
    Arnold Mitnitski
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Am Geriatr Soc 53:2184-9. 2005
    ..In samples (e.g., clinical/institutional) in which most people are frail, there is no relationship with age, suggesting that there are maximal values of deficit accumulation beyond which survival is unlikely...
  101. ncbi Depression as a risk factor for the incidence of first-ever stroke in 85-year-olds
    Martin Liebetrau
    Department of Neurology, Dr Horst Schmidt Klinik, Wiesbaden, Germany
    Stroke 39:1960-5. 2008
    ..Few studies have examined whether depression increases the risk for stroke in the very old and among the demented. We examined the relation between depression in 85-year-olds and the 3-year incidence of first-ever stroke...